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Heaithcare Products 4447412 ENZYME-CONTAINING DIGESTIVE AID COMPOSTIONS Gerald L Bilton A composition adapted to alleviate the symptons of digestive dysfunction comprising a mixture of coated beads incorporating pancreatic enzymes and proteolytic enzymes and having a gastric acid-resistant coating thereon, said beads being orally-administered in com- bination with granules comprising a choleretic a- gent, a hydrochloric acid salt and pepsin. 4447415 PLASMA-FREE MEDIUM FOR PLATELET STORAGE Gail A Rock, George A Adams, Rockcliffe Park, Canada Blood platelet concentrate in a plasma-free medium. Method for storage of blood platelets in a plasma-free medium which comprises cen- trifuging plasma to obtain a platelet pellet, removing the supernatant plasma, and resuspen- ding the platelet pellet in a balanced salt medium. The balanced salt medium is an isotonic solution and may be selected from well known physiologically tolerable salt mediums. Additives to enhance platelet storage can be ad- ded to the salt medium. A.A.A.B714 ANTIBIOTIC POLYPEPTIDE COMPOUNDS PREPARED FROM STAPHLOCOCCUS BACTERIA William J Cunliffe, Elizabeth Eady, Keith Hol- land, Bramhope, Nr Leeds, United Kingdom The invention relates to an antibiotic poly- peptide compound, or addition salt thereof. having a molecular weight no greater than 10000 and possessing bactericidal and bacteriolytic ac- tivities in respect of Gram-positive bacteria, the said compound comprising within the molecular structure thereof amino acid derivative units of formulae See Patent for Chemical Structure wherein NH2-RI-COOH, NH2-R2-COOH, NH2-R3-COOH. NH2-R4-COOH, NH2-R5- COOH, NH2-R6-COOH and NH2-R7-COOH respectively represent isoleucine, phenylalanine, alanine, aspartic acid. glutamic acid, lysine and glycine and See Patent for Chemical Structure represents proline The invention further pro- vides a process for the preparation of antibiotic polypeptides by the aerobic culturing of a strain of S. epidermidis. The invention also provides compositions comprising antibiotic substances and methods of treatment therewith. The inven- tion further provides a new strain of Staphylococcus epidermidis which produces the antibiotic polypeptides, compositions con- taining the said strain and a method of cosmetic or prophylactic treatment of the human skin with such compositions. 4448765 LIPOSOMES AND THEIR USE IN TREATING HUMAN OR OTHER MAMMALIAN PATIENTS Philip Ash. Robert C Hider, Colchester. United Kingdom assigned to National Research Development Corporation Microvesicles are stabilized by the incorporation of a polymer having aliphatic lipophilic groups with a chain of at least six atoms attached to the backbone thereof. Such microvesicles may in- corporate a physiologically active substance such as an antigenic material, an anti- inflammatory agent, a hormone, etc. 395

4447412 Enzyme-containing digestive AID compostions

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Heaithcare Products

4447412

E N Z Y M E - C O N T A I N I N G D I G E S T I V E A I D C O M P O S T I O N S

Gerald L Bilton

A composition adapted to alleviate the symptons of digestive dysfunction comprising a mixture of coated beads incorporating pancreatic enzymes and proteolytic enzymes and having a gastric acid-resistant coating thereon, said beads being orally-administered in com- bination with granules comprising a choleretic a- gent, a hydrochloric acid salt and pepsin.

4447415

P L A S M A - F R E E M E D I U M F O R P L A T E L E T S T O R A G E

Gail A Rock, George A Adams, Rockcliffe Park, Canada

Blood platelet concentrate in a plasma-free medium. Method for storage of blood platelets in a plasma-free medium which comprises cen- trifuging plasma to obtain a platelet pellet, removing the supernatant plasma, and resuspen- ding the platelet pellet in a balanced salt medium. The balanced salt medium is an isotonic solution and may be selected from well known physiologically tolerable salt mediums. Additives to enhance platelet storage can be ad- ded to the salt medium.

A.A.A.B714

A N T I B I O T I C P O L Y P E P T I D E C O M P O U N D S P R E P A R E D F R O M

S T A P H L O C O C C U S B A C T E R I A

William J Cunliffe, Elizabeth Eady, Keith Hol- land, Bramhope, Nr Leeds, United Kingdom

The invention relates to an antibiotic poly- peptide compound, or addition salt thereof. having a molecular weight no greater than 10000 and possessing bactericidal and bacteriolytic ac- tivities in respect of Gram-positive bacteria, the said compound comprising within the molecular structure thereof amino acid derivative units of formulae See Patent for Chemical Structure wherein NH2-RI-COOH, NH2-R2-COOH, NH2-R3-COOH. NH2-R4-COOH, NH2-R5- COOH, NH2-R6-COOH and NH2-R7-COOH respectively represent isoleucine, phenylalanine, alanine, aspartic acid. glutamic acid, lysine and glycine and See Patent for Chemical Structure represents proline The invention further pro- vides a process for the preparation of antibiotic polypeptides by the aerobic culturing of a strain of S. epidermidis. The invention also provides compositions comprising antibiotic substances and methods of treatment therewith. The inven- tion further provides a new strain of Staphylococcus epidermidis which produces the antibiotic polypeptides, compositions con- taining the said strain and a method of cosmetic or prophylactic treatment of the human skin with such compositions.

4448765

L I P O S O M E S A N D T H E I R U S E IN T R E A T I N G H U M A N O R O T H E R

M A M M A L I A N P A T I E N T S

Philip Ash. Robert C Hider, Colchester. United Kingdom assigned to National Research Development Corporation

Microvesicles are stabilized by the incorporation of a polymer having aliphatic lipophilic groups with a chain of at least six atoms attached to the backbone thereof. Such microvesicles may in- corporate a physiologically active substance such as an antigenic material, an anti- inflammatory agent, a hormone, etc.

395