PATENT ABSTRACTS

taking blood provides improved disease fighting characteristics in the derived product. Steps are provided for purification of the products such as removal of residual inducers or the treatment for presence of suspected hepatitis virus, etc.

4490358

S C R E E N I N G V A C C I N E S A N D I M M U N I Z A T I O N P R O C E S S

Mark I Greene, Bernard N Fields assigned to President and Fellows of Harvard College

Mammals are vaccinated against infectious or- ganisms and polypeptides are screened for utility as vaccines by a complementing set of mono- clonal antibodies, the first of which antibodies binds specifically to the site on the organism which itself binds specifically to a receptor on a host cell of the mammal, and the second of which binds specifically to the first. Vaccination is done with the second antibody alone, and screening is done by determining whether the polypeptide binds to the first antibody.

4490361

V I R U S I N A C T I V A T I N G H E A T T R E A T M E N T O F P L A S M A

F R A C T I O N S

Charles Heldebrant assigned to Alpha Therapeutic Corporation

A process is provided for heat treating a protein powder that includes mixing the powder into an organic liquid to form a suspension and heating the suspension for a selected time at a selected temperature. Such heat treatment inactiviates any virus associated with the protein while not substantially impairing the biological activity of the protein.

4490362

I M M U N O P O T E N T I A T O R C O M P R I S I N G T H E B C H A I N O F

R I C I N AS AN A C T I V E I N G R E D I E N T

Hiroshi Shionoya, Hitoshi Takeuchi, Gunki Funatsu, Saitama, Japan assigned to Eisai Co Ltd

An immunopotentiator comprising the B chain of ricin as an active ingredient. The immuno- potentiator serves to increase immune response to fungi, viruses and other microorganisms and

121

is therefore effective for prevention or treatment of infectious diseases by such microorganisms.

4490363

M E T O R P H A M I D E - A N O V E L M O R P H I N E - L I K E P E P T I D E

Jack D Barchas, Eckard Weber, Christopher Evans assigned to Board of Trustees of The Leland Stanford Junior University Stanford Univ

A morphine-like amidated opioid octapeptide metorphamide having the structure Try-Gly- Gly-Phe-Met-Arg-Arg-Val-NH2 has been isolated from bovine caudate nucleus extracts and synthesized by solid phase peptide synthesis methods. Metorphamide is thus far the only natural opioid peptide having a high mu-binding activity.

4490385

T R E A T M E N T O F A U T O - I M M U N E A N D I N F L A M M A T O R Y D I S E A S E S

Julia Lieb

A method for the treatment of inflammatory dis- orders and disorders of immunity, which dis- orders are characterized by excessive prostaglandin E2 biosynthesis, which method comprises administering an effective amount of a monoamine oxidase inhibitor.

4491578

M E T H O D O F S T I M U L A T I N G S A T I E T Y I N M A M M A L S

Steven Peikin

This disclosure relates to a method of eliciting satiety (psycho phenomenetic sense of being fil- led) in mammals through the administration of an effective amount of a trypsin inhibitor and is based on the postulate that the enzyme trypsin, normally secreted by the pancreas, constitutes a negative feedback signal for cholecystokinin secretion which in turn comprises a putative satiety signal; thus, the effect of the trypsin in- hibitor is to increase the concentration of cholecystokinin secretion advancing the sensa- tion of satiety resulting in a consequent decrease in food intake and, over time, body weight.