630 PATENT ABSTRACTS

This invention relates to a process for screening microorganisms for the production of extra- cellular enzymes. Colonies growing on the sur- face of a solid medium capable of extracellular enzyme synthesis are identified by reacting the enzyme or enzyme product surrounding each cology with an analytically indicatable reagent which does not adversely effect the viability of said colonies.

4882274

M E T H O D F O R S O L U B I L I Z A T I O N O F L O W - R A N K C O A L U S I N G A

C E L L - F R E E E N Z Y M A T I C S Y S T E M

in step (b). By using the process it is possible to stably and efficiently carry out conversion of AMP into ATP over a long period of time. Fur- ther, it is possible to carry out continuously and economically an enzymic reaction using ATP as an auxiliary factor with very good efficiency. Whereby it has become possible to practically operate the so-called bioreactor wherein syn- thetic reactions in the living body are carried out as industrial chemical reactions outside the living body.

4883760

D E V I C E F O R P E R F O R M I N G E N Z Y M E I M M U N O A S S A Y S

John Pyne, Dorothy Stewart, James Fredrickson, Martin S Cohen assigned to Elec- tric Power Research Institute Inc

A method is provided for isolating an extra- cellular product from white rot fungi. The extra- cellular product is useful for biosolubilizing low- rank coals to form water-soluble products.

4882276

P R O C E S S F O R P R O D U C I N G P H Y S I O L O G I C A L L Y A C T I V E

S U B S T A N C E B Y M U L T I E N Z Y M E P R O C E S S

Donald R Heelies, Mississauga, Canada as- signed to Adi Diagnostics Inc

The device has a transparent capillary assay tube attached at its upper end to a lateral portion of the support structure of the device. The lower free end of the assay tube is engageable with an absorbent material upon manual downward deflection of the support structure. The assay tube is filled through a funnel shaped aperture in the lateral portion of the device, and the tube is drained by engaging the lower free end of the tube with the absorbent material. By attaching appropriate antibody, antigen or hapten to the inner surface of the tube, immunoassays may be performed in the tube.

Kazutomo Imahori, Hitoshi Kondo, Hiroshi Nakajima, Tatsuo lwasaki, Tokyo, Japan as- signed to Imahori Kazutomo; Kenkyusho Rikagaku; Unitika L

A process for converting AMP into ATP which comprises (a) using an enzyme which converts AMP into ADP and has been produced from microorganisms having an optimum growth temperature of 50 degrees C. to 85 degrees C. and an enzyme which converts ADP into ATP and has been produced from microorganisms having an optimum growth temperature of 50 degrees to 85 degrees C. is disclosed. In addition, there is disclosed a process for producing a phys- iologically active substance by a multienzyme process which comprises forming ATP from AMP by the step (a), (b) synthesizing a phys- iologically active substance with the resulting ATP, coverting AMP resulting from the reaction in step (b) into ATP by the reaction in step (a), and repeatedly utilizing the converted ATP for synthesis of the physiologically active substance

4885151

D I A G N O S T I C A I D F O R T H E S C I N T I G R A P H I C

V I S U A L I Z A T I O N O F M A L I G N A N T T U M O R S C O M P R I S I N G T H E

S U B S T A N C E O B T A I N E D F R O M E N Z Y M A T I C P R O C E S S I N G O F

M U R E I N U S I N G H E N ' S E G G W H I T E L Y S O Z Y M E

Erich Oberhausen, Ludwig Kuhlmann, Gerhard Seibert, Axe Steinstrasser, Hans-Joachi Schroth, Karl-Heinz Bremer, Homburg/Saar, Federal Republic Of Germany assigned to Hoechst Ak- tiengesellschaft

A diagnostic aid for the scintigraphic visualiza- tion of malignant tumors which contains a radionuclide which is bonded by means of a complex-forming agent to the substance ob- tained by the enzymatic processing of murein