48TH ANNUAL REVIEW 2015/16 - Tenovus Scotland

T O D A Y ’ S R E S E A R C H ~ T O M O R R O W ’ S H E A L T Hwww.tenovus-scotland.org.uk

TODAY’S RESEARCH ~ TOMORROW’S HEALTH

48TH ANNUAL REVIEW2015/16



2015/16 at a glanceResearch Grants

Grants of over £1million were approved for 44 Projects

Administration CostAdministration costs were only 3% of the total cost of approved grants

New Strathclyde ChairmanProfessor Kenneth Paterson has succeeded Dr Alistair Beattie as Strathclyde Chairman.

A huge debt is owed to Alistair for many years loyal service

to the Strathclyde Committee

The Princess Royal Tenovus Scotland Medical Research Scholarship

Angela Ianniciello (University of Glasgow) was awarded a PhD scholarship

to further understand how autophagy controls the way in which CML stem cells function

and, using the best laboratory models including patient-derived CML stem cells,

test new drugs that block autophagy

The 2015 Lady Illingworth Award Professor Andrew Tatham (University of Edinburgh) was the recipient of this prize for his

research which is focused on improving the understanding of chronic eye disease and

how it affects elderly patients’ quality of life. This is awarded periodically to a person or

persons who have made an outstanding contribution to the understanding of the

disabilities which affect elderly people within the British Isles

The Sir Robin MacLellan AwardDr Anke J Roelofs (University of Aberdeen) was the winner. Her Final Report on her

research work was judged the most outstanding for the year

We were founded in 1967 by Sir Charles Illingworth

We fund start up medical research studies in Scotland

We have awarded research grants of seven million pounds over the last ten years

Administration costs have been only 6% of income over the same ten year period

Our start up funding has contributed to 17 times further funding from major research bodies

2 T O D A Y ’ S R E S E A R C H ~ T O M O R R O W ’ S H E A L T H

Contents

2Background and

2015/16 at a glance

3Chairman’s Comments

4-5Research Grants and Awards

6-9Regions

10NSAC

11Financial Review

12Office Bearers

Tenovus Scotland will celebrate its Golden Jubileein 2017. Those past five decades have seen asteady stream of very valuable support formedical research in Scotland, and we have beenable to offer funding across a very broadspectrum of subject areas. Most of our supporthas been, and continues to be, targeted on younginvestigators, helping them on to the first rungs ofthe scientific research ladder. It has beengratifying to follow the progress of thoserecipients, many of whom have gone on to beleaders in their own fields.

The programme of Princess Royal TenovusScotland Medical Research Scholarships launchedin the summer of 2014 with the enthusiasticendorsement of our Patron is now firmlyestablished. Anna Mariano BSc is now into thesecond year of her research into Huntingdon’sDisease at the University of Dundee. The secondScholarship, funded by the Ian Sunter CharitableTrust, has been awarded to Angela Ianniciello,who has embarked on research into ChronicMyeloid Leukaemia at the University of Glasgow.Recruitment is underway for a third Scholarshipto be funded by the John Shivas Memorial Trust.This Scholar will study in the University ofAberdeen and, as the Scholars are spread aroundour Regions, we are meeting our target of havinga new Scholarship every year. The standard of theScholars already in post reflects the fact thatthese awards are extremely competitive andhighly prestigious.

While a great deal of work has gone intoestablishing the Scholarship programme, this hasnot detracted from the ongoing ‘core business’ ofthe Charity, which is to fund young investigatorsto embark on the research that has so oftenallowed more substantial and longer term fundingfrom the major medical UK research organisationssuch as the Wellcome Trust and the MedicalResearch Council.

We were pleased once again to support theannual Glasgow University Tenovus ScotlandSymposium. The recipient of the TenovusScotland Medal was Professor Ian Deary of theUniversity of Edinburgh.

The recipient of the Lady Illingworth Award wasDr Andrew Tatham, NHS Scotland ResearchFellow and Honorary Clinical Senior Lecturer,University of Edinburgh. This prize is awardedperiodically to a person or persons who arethought to have made an outstanding contributionto the understanding of the disabilities that affectelderly people within the British Isles.

The Sir Robin MacLellan Travel Award wasawarded to Dr Anke J Roelofs of the University ofAberdeen. This award is made annually to theresearcher whose Final Report on their researchwork has been judged the most outstanding forthe year.

We are extremely grateful to Professor DavidGalloway, President of the Royal College ofPhysicians and Surgeons of Glasgow, for thecontinuing use of College facilities.

We were greatly saddened by the death inDecember 2015 of Vice President Professor SirRoddy MacSween, who was Chairman of theNational Committee from 2006 until 2011, whenhe was forced to stand down on account of ill-health. Roddy was an internationally renownedacademic pathologist and many of his friends,colleagues, and former trainees around the worldhave contributed to his memory. We weredelighted when Lady MacSween and the familydecided that the funds collected should beentrusted to Tenovus and this will allow anongoing award to be established as a lastingmemorial to Roddy.

The work of all committee members (National,Regional and Scientific Advisory) continues to beessential. The success of the Charity stems fromtheir dedication and ensures funds are wiselyallocated. The Regional Secretaries are unsungheroes of the organisation ensuring the work ofthe Regional Committees continues smoothly. Atthe National level, the key figures are the GeneralSecretary, Iain McFadzean, the HonoraryTreasurer, Francis McCrossin, and the Chairmanof the Scientific Advisory Committee, ProfessorAlan Struthers, who are hugely committed. DrAlistair Beattie, after loyal service to theStrathclyde Committee for many years, handedover as its chairman to Professor KennethPaterson. David Land has concluded a very longperiod of dedicated management of the financesof the Edinburgh Region.

As always there continues to be an infusion ofnew blood into all the Committees, whichemphasises the vigour of the organisation. TheTenovus Scotland family continues in good spiritsand does so with the encouragement of everyonewho supports the ideals of the Charity. I amconfident that this essential support will beforthcoming in the future so that TenovusScotland can continue its fine record of successwell into its next half century.

Professor Andrew CalderChairman

3T O D A Y ’ S R E S E A R C H ~ T O M O R R O W ’ S H E A L T H

DonorsOur sincere thanks to all our donorsAnonymousBrodies LLPSt Andrew’s Society, AlabamaMs C CochraneMs J DunlopMr A TannahillIn memory of Sir Roddy MacSween

Professor H Faith, Hong KongProfessor L Ferrell, San FranciscoProfessor R Gill, San FranciscoProfessor P Hyrtiroglu, ThessalonikiDr P Y Lam, Hong KongCollection at Funeral Service, Mearns Parish Church

“While a great deal ofwork has gone intoestablishing the Scholarshipprogramme, this has notdetracted from the ongoing‘core business’ of theCharity, which is to fundyoung investigators toembark on the research thathas so often allowed moresubstantial and longer termfunding from the majormedical UK researchorganisations…”

CHAIRMAN’S COMMENTS


“The grant from TenovusScotland supplied me withcritical support which could lead to the increasedchance of securing futurefunding”

“The key data generatedduring the pilotinvestigation funded by theTenovus Scotland awardwas most valuable inproviding the necessarypreliminary material tosupport our AMS/Wellcome application”

“Pilot data is an essentialrequirement in applying forlarge grants. This fundingfrom Tenovus Scotland willallow us to obtain proof ofconcept data of our novelapproach to the treatment ofcancer to backup a fullgrant application”

RESEARCH GRANTS &AWARDS 2015/16Pilot Projects (Grants up to £15,000)

EDINBURGHDr Jessy Cartier Understanding the effects of stress hormones on brain development in

preterm babiesDr Katherine Staines Investigating new therapies for osteoarthritisDr Lyndsay Murray Using mouse models to Investigating why potential treatments are less

effective after the symptoms appear in Childhood Motor Neuron Disease

GRAMPIANDr Gemma Barron A cell study to determine the effect of Scottish plant extracts on drug

transport: can the failure of cancer drugs be overcome?Dr Dawn Thompson A potential new drug target for resolving sepsisDr Tim Smith Treatment of colorectal cancer using cancer-homing radioactive

moleculesDr Frank Ward IL-33 expression in lung lining cells as a potential biomarker for asthmaDr Gabriella Baio To study the role of serotonin in breast cancer by PET/CT imagingDr Wenlong Huang Combining silk biomaterial, omega-3 fatty acid, and electric stimulation

to repair spinal cord injuryDr James Hislop Manipulation of cAMP signals to reduce vascular restenosisProfessor Gernot Riedel The role of immune responses in the pathology of Parkinson's disease

STRATHCLYDEDr Niall Simpson Measuring protein flexibility with Two-Dimensional Infrared

Spectroscopy: a new perspective on the problem of drug resistance inthe treatment of tuberculosis

Ms Janice Spencer Characterizing the bacterial organisms of the gut of mice and hamsterto identify those species which protect mice from fatal infection withClostridium difficile

Dr Susan Chalmers Imaging and treating changes within brain cells during degenerativediseases

Dr Alison Michie A study to identify specific novel factors in blood cancer cells that caninfluence the development of treatment resistance

Dr Gillian Hunter Characterising two candidate genes for spinal muscular atrophy todetermine whether they are suitable targets for therapeutic intervention

Dr Margaret Rose Cunningham Investigating mechanisms that contribute towards abnormal plateletfunction

Dr Mairi E Sandison A new device to model cardiovascular disease that enables tracking ofbehavioural changes in individual cells within vascular tissues

Dr Aaron Lau A switchable material for stem cell manufacturingDr Gianluca Grassia Development of novel approaches to reduce vascular diseasesDr John S Bett How defects in the brain’s protein destruction system are linked to age-

related brain disorders

TAYSIDEDr Clare Clarke How does medication use affect levels of physical activity in older

people?Dr Matthew Holden Mapping the genetic diversity of the pathogen, Staphylococcus aureus,

directly from the skin of eczema patientsDr Craig Heath How common is epilepsy in those attending opioid replacement

programmes and does attendance at such programmes improvemedication adherence and reduce use of unscheduled care, seriousharm or death?

Dr Helge C Dorfmueller Towards the discovery of chemical tools to prevent human infectioncaused by Streptococcus pyogenes bacteria

Dr Christos Pliotas Tackling Antimicrobial Resistance (AMR) by controlled manipulation ofcell membrane channel pores -molecular gating studies lead to effectivedrug targeting

Dr Soo-Youn Choi Unravelling novel regulatory networks controlling immune responsesand lymphomagenesis

Dr Michael Nevels A new strategy of fighting human Cytomegalovirus infectionsDr Lee Kang Targeting cardiac fibrosis and insulin resistance to treat heart failureDr Weihua Meng An association study linking e-health records and DNA chips to identify

genes for diabetic retinopathyDr Greg Findlay Using chemical tools to develop novel approaches to tissue replacement

therapyDr Fiona Bull Does inhibition of c-Src kinase enable morphine to produce a long

lasting reduction in persistent pain?Dr Maurice AM van Steensel Understanding kidney cancer by studying a rare genetic diseaseMr Aidan Rose Investigating cancer promoting mechanisms in skin cancerDr Victoria Sherwood Investigations into a novel drug target for skin cancer treatment

Large Grants (up to £100,000)

TAYSIDEDr Samira Bell Using linkage of hospital datasets to find out whether adjusting the

timing of operations and x-ray scans using dye can reduce the risk ofkidney failure

Mrs E Jane Macaskill Pre-surgical imaging and biological study of patients with hormonepositive early breast cancer: can we predict those with resistantdisease?

Dr R Petty Characterisation of a new subgroup of oesophageal cancers that couldbe treated with targeted therapies thereby avoiding chemotherapy andimproving clinical outcomes

Dr Faisel Khan A preliminary study in patients to see how inflammation contributes toheart and blood vessel disease

Dr Daniel Morales Angiotensin converting enzyme inhibitors in asthma:pharmacoepidemiology studies using linked UK health data

Dr Yogesh Kulathu How does the MINDY family of enzymes protect us from ageing andneurodegeneration?

Dr Maurice AM van Steensel A new function for an ancient protein reveals causes of kidney cancerDr Mark Larance Does the immune system mediate the beneficial effects of intermittent

fasting?

The Princess Royal Tenovus Scotland Medical Research Scholarship

STRATHCLYDEAngela Ianniciello Awarded a PhD scholarship to further understand how autophagy (University of Glasgow) controls the way in which CML stem cells function and use the best

laboratory models, including patient-derived CML stem cells, to test newdrugs that block autophagy

The 2015 Lady Illingworth Award

NATIONALProfessor Andrew Tatham This prize is awarded periodically to a person or persons who have (University of Edinburgh) made an outstanding contribution to the understanding of the

disabilities which affect elderly people within the British Isles. ProfessorTatham's research is focused on improving the understanding of chroniceye disease and how it affects elderly patients’ quality of life

The Sir Robin MacLellan Award

NATIONALDr Anke J Roelofs Most outstanding Final Report on research work for the year - (University of Aberdeen) Investigating a protein called Yap as a potential novel therapeutic target

for rheumatoid arthritis


“The award was my firstresearch grant as a youngPrincipal Investigator andwas instrumental inallowing me to completevital experiments towards ahigh impact paper thatincreases our understandingof inherited motor neuronedisease”

“Thanks to the funding, Ihave published a paper ondiabetic cataract in IOVSwhich is a famous eyejournal”

“I am excited to be able toinvestigate the safety of acommonly used medicine inpeople with asthma. Thiswork has the potential tomake a direct impact onpatient care and I am verygrateful to Tenovus Scotlandfor this opportunity”

The Edinburgh Regional Committee hascontinued to profile-build and fund-raise over thelast 12 months. It has met on four occasions inthe offices of Messrs Balfour+Manson LLP,courtesy of Mr David Campbell, WS.

Applications received and Project reportsDuring the year the Committee received 11 grantapplications. These were considered locally andsix were then submitted to the National ScientificAdvisory Committee (NSAC) for their assessment.Ultimately, it was decided to fund three projectsto a sum of some £30,000. As has been ourpractice in previous years, these were passed tothe Nancy Massey Charitable Trust, which agreedto fund one of the three. This meant that at year-end we had a small surplus of about £3,000.It has been decided that the Edinburgh RegionalCommittee will move our grant applicationprocess from September to May. This means thatour next application closing date will be 1 May2017.

The Committee received four final reports andone interim report during the year. All were felt tobe satisfactory with the exception of one of thefinal reports, which was not in an acceptableform. The revised report is awaited.

Income generation and eventsMrs Helen Finlayson of the Committee arrangedanother very successful ladies fashion show,which was held on the evening of 20 May 2015at Hobbs, George Street, Edinburgh.

The Edinburgh Committee hosted an eveningreception for senior doctors and researchers atthe Edinburgh Clinic on 1 October 2015. MrStephen O’Neil, University of Edinburgh, spoke

on his research, which had been funded initiallyby Tenovus. The output of his work on renalinjury after transplantation was a PhD, threeprizes (Chiene Medal, Moynihan Prize and SirRobin MacLellan Travel Award) six publicationsand £240,000 of additional funding including aMRC Fellowship. Sheriff Ian Simpson, QC, spokeabout his latest crime novel, which is set in StAndrews at the time of the 1927 OpenChampionship.

Committee and thanksMr David Land, CA, our Honorary Treasurer, hasdecided, after more years than he cares toremember in the role, to retire. He is warmlythanked for all his efforts over those years.

My thanks go again to Mrs Kay Rich for hertireless work as Honorary Secretary.

Mr James WatsonChairman


Edinburgh CommitteeAS AT 31 MARCH 2016

CHAIRMr J D WatsonHON. TREASURERMr D S Land COMMITTEEProfessor D Bell, Professor A A Calder, Mr D H Campbell, Mr A Corstorphine, Dr D Davidson, Miss F V N Din, Dr S Farrington, Mrs H A Finlayson, Dr A Patrick

LSAC MEMBERSDr L Bath, Professor D Bell, Professor A A Calder,Dr D Davidson, Ms F V N Din, Dr S Farrington,Dr A Patrick, Mr J D Watson

Edinburgh Regional SecretaryMRS KAY M RICH Regional Secretary

Edinburgh Committee, Tenovus Scotland, 8 Queens Avenue South

Edinburgh EH4 2BUTel: 0131 332 8502

Email: [email protected]

DonorsOur sincere thanks to all our donorsThe Nancie Massey Charitable TrustW J Underwood's Charitable TrustAnonymousDr H BrebnerDr N D C FinlaysonMr R GregorMr C KerrSheriff I SimpsonMrs R F StewartMiss J S C Stuart

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INCOME, RESEARCH GRANTS & ADMINISTRATION EXPENSES - £000

“The output of Mr Stephen O’Neil’s work on renal injury aftertransplantation, which had been funded initially by Tenovus, wasa PhD, three prizes (Chiene Medal, Moynihan Prize and Sir Robin MacLellan Travel Award), six publications and£240,000 of additional funding including a MRC Fellowship”

EDINBURGH

Tenovus Scotland Grampian is proud to continueto fund young researchers and innovative pilotstudies in our three local Universities (AberdeenUniversity, Robert Gordon University and theUniversity of the Highlands and Islands), in bothlaboratory and clinical disciplines. We remaindeeply grateful to those who have been generousenough to bequeath and donate monies to us tosupport this crucial work and to enable us to fundour PhD scholars.

Applications received and Project reportsThe single annual cycle of research fundingcommenced again in September 2015 with aview to awards being granted for researchprojects to start in March 2016. A total of 18applications were reviewed by the Local ScientificAdvisory Committee, of which ten were forwardedto the National Scientific Advisory Committee(NSAC). The NSAC ranking led to funding beingoffered for eight projects; four of theseparticularly fulfilled the preferences of the LilyCharlton Bequest, which amounted to nearly£40,000, the others being supported from theRegional Committee funds.

The John Shivas Memorial Trust has permittedTenovus Grampian to fund a HRH Princess RoyalMedical Research Scholarship over four years, tocommence in October 2016; applications havebeen scrutinized and four candidates have beeninterviewed.

Interim and final reports have been received in2015/2016 and our three Moulton Barrett PhDscholars continue to give interim presentations, inturn, at the Grampian Committee quarterlymeetings.

Income generation and eventsWe had another very successful Lawyers’Continuing Professional Development Evening atthe Royal Northern and University Club in Januarywhen Professor Roddy Paisley, Professor in ScotsLaw at Aberdeen University, delivered anentertaining and engaging educational talk, to a

capacity gathering, relating to legislationsurrounding death and inheritance.

Our financial status has permitted us to continueto finance our PhD scholars and a variety ofattractive projects as outlined above. The diversenature of the projects funded by TenovusGrampian is gratifying. These include researchinto cancer, cardiovascular and neurodegenerativedisease.

We maintain a close and effective relationshipwith the Research and Development and FinanceDepartments of all the Universities which hasfacilitated improvements in rigorous tracking andappropriate payment of funds, and we arecontributing to the unified application processbeing developed by the National Committee.

A local fundraiser to enhance our committee ishoped to be recruited in the forthcoming year.

The highlight of our year was the visit of ourPatron, HRH The Princess Royal, on 2 July 2015,when she viewed posters prepared by ourresearchers and scholars and met Members ofthe Local and National Committees as well aslocal dignitaries and contributors, prior to openinga new wing of Robert Gordon University.

Committee and thanksThe last year has seen the retirement of our ViceChair, Mr Erland Flett. He has been replaced onthe Committee by Mr Forbes McLennan, aprominent Aberdeen solicitor. Professor CherryWainwright has been elected as the new ViceChair. The Chair wishes to express hisconsiderable gratitude to the Hon. Secretary, Hon.Treasurer and other members of the Committeefor their tireless efforts on behalf of TenovusGrampian and Tenovus Scotland. We have beenably assisted by Ms Marilene Walker over this lastyear with the administration of our fundedresearch projects.

Professor Jamie GrieveChairman


Grampian CommitteeAS AT 31 MARCH 2016

CHAIRMANProfessor J GrieveVICE CHAIRMANProfessor Cherry WainwrightHON. TREASURERMr D FraserCOMMITTEEMr G Benvie, Professor B Connolly, Dr S Duncan, Mr F McLellan, Mr A Marshall, Professor J Maxwell

LSAC MEMBERSDr S Duncan, Professor J Grieve, Professor J Maxwell

Grampian Honorary SecretaryMR JONATHAN F S YOUNG

Honorary SecretaryGrampian Committee, Tenovus Scotland,

Old Braco, Burnhervie, InverurieAberdeenshire AB51 5LB

Tel: 01467 681380Email: [email protected]

DonorsOur sincere thanks to all our donorsMs A MacdonaldMr D Yule

LegaciesWe are grateful for the following legaciesMr I J BurnessB D Taylor

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“The highlight of our year was the visit of our Patron, HRH ThePrincess Royal, on 2 July 2015, when she viewed posters preparedby our researchers and scholars and met members of the Local andNational Committees as well as local dignitaries and contributors”

GRAMPIAN

The Strathclyde Committee has, as usual, met onfour occasions in the past year, continuing totake advantage of the facilities and hospitality ofthe Medical and Dental Defence Union ofScotland at its offices in Glasgow. While theaward of new grant funding was the main focusof two meetings, the others gave some time todiscuss fund-raising and even the ethosunderpinning the awards being made.

Applications received and Project reportsThis has been a busy year with a total of 28applications for funding received. We have beengrateful for the work of our Local ScientificAdvisory Committee (LSAC) in assessing allapplications and in recommending 10 projectsfor funding; all 10 funding suggestions weresubsequently approved by the National ScientificCommittee leading to project support totalling£115,470. Funded projects covered a widevariety of fields, including oncology, cardiologyand infectious diseases. The introduction of thee-Tapestry database has allowed the projectsubmission and assessment process to go‘paperless’, an important step with significantsavings in both time and expense.

Thanks to the generosity of the Trustees of theIan Sunter Charitable Trust, £90,000 was madeavailable in June 2015 to support a second HRHPrincess Royal Tenovus Scotland MedicalResearch Scholarship, in the field of oncology. Arapid recruitment process was put in place withexcellent support from LSAC members, and MsAngela Ianniciello was appointed to undertake aPhD project (supervised by Dr Vignar Helgason)at the University of Glasgow from 1 October2015.

Interim and final project reports were reviewedat each meeting. While research progress

inevitably differs amongst projects, all showedevidence of significant learnings from the worksupported by Tenovus, and several investigatorspaid specific tribute to the impact of fundingfrom Tenovus on their research activities.

Income generation and eventsAs in the past, the major source of income wasdonations from Charitable Trusts, which totalled£165,761. In line with many other charities,income from fund-raising events has generallyfallen, despite the excellent work of thoseorganising such events, and while continuedpromotion of events is good for raising the profileof Tenovus, it seems unlikely that such eventswill again be a major source of income. Fund-raising from corporate sources, even in thesetimes of austerity, may be more fruitful andexpert advice is being sought to offer help and support to our volunteer fund-raisers. Asever, the Golf Day at Glenbervie in May was a big success - it is set to be repeated this year!

Committee and thanksThe Committee extended its grateful thanks to DrAlistair Beattie, who completed his four-yearterm as Chair in June 2015. All Committeemembers have participated with enthusiasm, butI would particularly single out Mrs Sue Ogden,who works tirelessly as Regional Secretary andco-ordinates all the Committee’s activitiesexpertly. Our LSAC members have had aparticularly onerous year but have respondedmagnificently to the demands on their time andexpertise, and I have already noted the valuable contribution from the Ian SunterCharitable Trust and others. All have my sincerethanks.

Professor Kenneth PatersonChairman


Strathclyde CommitteeAS AT 31 MARCH 2016

CHAIRProfessor K R PatersonHON. TREASURERMr D MacLucas COMMITTEEMrs T Begg, Mrs G Buchanan, Mr J Drury, Professor AFoulis, Professor D Galloway, Mrs I Lindsay, Mrs J Macanna, Mr I MacDonald, Mrs L Mawson LSAC MEMBERSDr H Carswell, Professor N Keith, Dr S Lang,Professor I McInnes, Professor S Pyne

STRATHCLYDE FUNDRAISING COMMITTEECHAIRMrs J MacannaHON. TREASURERMrs G Buchanan COMMITTEEMrs C Donald, Mrs L Mawson, Mrs S Tolmie

Strathclyde Regional SecretaryMRS SUE OGDEN Regional Secretary

Strathclyde Committee, Tenovus Scotland at Royal College of Physicians

& Surgeons Glasgow232-242 St Vincent Street, Glasgow G2 5RJ

Tel: 0141 221 6268Email: [email protected]

DonorsOur sincere thanks to all our donorsThe Alphaone TrustThe WA Cargill FundCommonweal Fund Clerk of Trades HouseThe Fraser FoundationMV Hillhouse TrustThe Jeffrey Charitable TrustThe John Kemp Charitable TrustW M Mann FoundationThe Martin Charitable TrustThe Martin Connell Charitable TrustMEB Charitable TrustMerchants House of GlasgowThe Ronald Miller FoundationThe Helen A Reid Charitable TrustThe Ian Sunter Charitable TrustThe Templeton Goodwill TrustThe Tennant Southpark Charitable TrustThe Iris and Alexander Walker-Naddell TrustAlma and Leslie Wolfson Charitable TrustArnold Clark LtdWylie & Bisset LLPMrs R AndrewsMr WK BeggMr D G BrownMrs N ChristieMiss A F CrowtherMrs F CutlerLady C GoldbergMrs S A HarveyMrs I B HayMrs E A IllingworthMr P KerrDr H LairdMrs K M E ListonMr I MacDonaldThe Rt Hon The Lord Macfarlane of BearsdenLady MacSweenProfessor Sir Roddy MacSweenMrs J MathesonDr A G MathiesonMr M McIverMrs M McRaeDr I D MelvilleMr A K MortonMrs M O'ConnerMr J SinclairMrs M StuartMr A B Tunnock CBEMs P WestonMrs J M Young

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“Thanks to the generosity of the Trustees of the Ian SunterCharitable Trust, £90,000 was made available in June 2015 tosupport a second HRH Princess Royal Tenovus ScotlandMedical Research Scholarship, in the field of oncology”

STRATHCLYDE

Tenovus Tayside has had another successful yearin 2015/16.

Applications received and Project reportsThe Committee has been very fortunate to havehad a total sum of just over £734,000 availablefor supporting research projects. This was raisedthrough donations from a number of local Trusts,legacies and fundraising events. During the year40 small grant applications and 21 largerapplications were received and all were fullypeer-reviewed by the Local Scientific AdvisoryCommittee. The available funds allowed 14 smallawards and eight large projects to be supported,following further scrutiny and support from theNational Scientific Advisory Committee.

Seven final reports, all deemed highlysatisfactory, were received.

Income generation and eventsThe Events Committee, led by Mrs Gloria Burns,has been very active throughout the year,arranging a number of functions. A particularhighlight was a musical evening held in DundeeHigh School at which outstanding performanceswere given by pupils from the school, membersof Dundee Symphony Orchestra, and a numberof very talented musicians from NinewellsHospital and Medical School. A golf outing,bridge lunches, and the annual dinner, as alwaysa highly popular event, raised £7,443.

One very successful development was ascientific symposium for our local lay supportersto hear more about some of the researchprojects that have benefited from Tenovusfunding – a number of these have had majorinternational impact and have resulted insubstantial further research funding from othermajor Research Councils and Charities. This

opportunity gave supporters the chance to meetsome of the very enthusiastic clinical and non-clinical scientific research staff in person, whichwas much appreciated by both the supportersand the research staff.

Committee and thanksAs always, the work of Tenovus depends on theenthusiastic support of our Committee Members,including our Scientific Advisory Committee. Inthis regard, we have been very sorry to loseProfessor Sara Marshall, who has moved fromDundee to London; however, her role of Chair ofthe Scientific Advisory Committee and memberof our full Committee has been taken byProfessor Tim Hales, who has already steppedvery ably into her shoes.

Professor John ConnellChairman


Tayside CommitteeAS AT 31 MARCH 2016

HON. PRESIDENTLady Fiona FraserVICE PRESIDENTSMrs P Dunn, Mr N J RobertsonCHAIRMANProfessor J M Connell VICE CHAIRMANMr A F McDonald TREASURERMr J M C WilsonCOMMITTEEMrs G Burns, Mr M Etherington, Professor T Hales,Professor P W Howie, Mr D J Smith, Mr D J Young

LSAC MEMBERSProfessor T Hales, Professor C Lang, Dr S Rocha, Dr F Williams

TAYSIDE EVENTS COMMITTEECHAIRMrs G Burns COMMITTEEMrs A Anderson, Mrs D Beattie, Mrs M Boyle, Dr B Coupar, Dr J Forsyth, Mrs C Fowlie, Mrs M Graham, Mrs A Gray, Mrs U Horspool, Mrs A Mackay, Dr J McEwen, Dr A Morris, Mrs M Munro, Mrs N Smith, Dr C Taig, Mrs D Willliamson

Tayside Regional SecretaryMRS MARGARET LAWSON Regional Secretary

Tayside Committee, Tenovus ScotlandMedical Research Institute, Corridor A, Level 7

University of Dundee, Ninewells Hospital & Medical School, Dundee DD1 9SY

Tel: 01382 383624Email: [email protected]

[email protected]

DonorsOur sincere thanks to all our donorsDundee Ladies ProbusMonifieth Ladies ClubAnonymous TrustLord Armistead Dundee TrustThe Evelyn Farris Mudie TrustIBB TrustLarg Family TrustThe Leng Charitable TrustAM Pilkington's Charitable TrustDr J M AndersonMrs BastableDr J A ColeiroProfessor C Florey Dr A ForresterMrs R HodgsonMr S InverarityMrs H M JamiesonMs S MayMr F McManusMrs E A MussenMr N J A RobertsonMrs L ScottDowager Countess of StrathmoreMrs Y J Taylor in memory of her son

LegaciesWe are grateful for the following legaciesMrs A CampbellMs J B MorrisonMs M Reid

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“The available funds allowed 14 small awards and eight largeprojects to be supported, following further scrutiny and supportfrom the National Scientific Advisory Committee”

TAYSIDE

A unique feature of Tenovus Scotland as aresearch funder is that money raised locally isspent locally on research. This avoids thesituation whereby money raised in one place is allspent elsewhere with no local benefit. There aremany advantages in this Tenovus model offunding research. A major one is that a strongbond can form between local fundraisers andlocal researchers. This bond is not only aninterpersonal one but it also means that localfundraisers know exactly what research questionsare being addressed by the money they raised. Asa result, Tenovus fundraisers feel more“ownership” of the research they fund and can,as a result, feel more motivated to raise funds,knowing how “exciting” and important the exactresearch is that they are funding. Contrast thatwith a UK wide charity, where the local fundraiserhas no idea exactly which research projects goahead as a result of their money.

Of course, safeguards are necessary in such asystem as it must still be the case that it is onlythe best ideas that are pursued. To meet the twinobjectives of local accountability and of fundingthe best ideas, Tenovus has a unique system ofdouble scrutiny of potential applications in thatthere are both local and national scientificadvisory committees. Knowing the local fundsavailable, the Local Scientific Advisory Committee(LSAC) firstly selects the best local applications.These selected projects are then sent to theseparate Tenovus national committee called theNational Scientific Advisory Committee (NSAC).The NSAC acts as “double scrutiny” of proposedprojects to ensure all selected projects meet thehighest standard of research. Only if a project israted highly by both the LSAC and NSAC will it befunded and go ahead. This also means that theNSAC assesses projects from all four RegionalCommittees and can ensure equivalently highstandards in all Regions.

Each year, there is a little turnover in themembers of the NSAC. This year, our Grampianrepresentative, Professor Russell Petty, movedfrom Grampian to Tayside. While Tayside was verypleased to welcome Prof Petty (such that he wasimmediately recruited to the Tayside RegionalCommittee), it did mean there was a gap withregard to Grampian in the NSAC. I am delighted toreport that Prof Zosia Miedzybrodzka has takenover as the Grampian representative on theNSAC. She is Professor of Medical Genetics in

Aberdeen. We very much welcome her taking onthis role and, with the increasing importance ofDNA and genetics in medical research, it isentirely appropriate to have specific expertise ongenetics in the NSAC. This nicely complementsour current expertise in Obstetrics/Gynaecology(Dr Denison), Clinical Imaging/Neuroscience (ProfSteele), and Cardiovascular/Endocrinology (DrFreel).

Here is a flavour of some of the projects wefunded this year:

• In Grampian, Fiona Murray will be exploring apotential culprit (Interleukin 33 = IL33) in patientswith pulmonary hypertension. Pulmonaryhypertension is a serious condition whereconstricted blood vessels in the lung causesevere breathlessness and early death. Dr Murraywill be exploring whether manipulating IL-33effects will help this condition. She has promisingpreliminary data, and will now explore thisfurther.

• In Lothian, Katherine Staines will be addressingthe common problem of Osteoarthritis (OA). Shewill be exploring how a certain protein called E11glycoprotein influences the all-important bonecells in OA. This could lead to a new treatment forOA based on manipulating this protein.

• In Tayside, Drs Maccaski & Vinnacombe, alongwith Professor Evans, will examine which factorspredict how breast cancer responds to(endocrine) therapy. They will explore a wholehost of different possible (biological andradiological) mediators of success versus failurein this therapy. They could well discover one ortwo mediating factors that have never beforebeen identified. If so, modifying standardtherapy accordingly could well increase thesuccess rate, and decrease the failure rate of ourcurrent therapy.

The above are just a few of the around 40applications funded this year and the NSAC isvery hopeful that many of these pilot projects willproduce positive results, leading to moredefinitive larger projects and, ultimately, todistinct advances in medical therapies.

Professor Allan Struthers, ChairmanProfessor of Cardiovascular MedicineUniversity of Dundee


The National ScientificAdvisory CommitteeAS AT 31 MARCH 2016

CHAIRMANProfessor A D StruthersCOMMITTEEDr F DenisonDr M Freel Professor Z MiedzybrodzkaProfessor D Steele

THE NATIONAL SCIENTIFIC ADVISORYCOMMITTEE

“To meet the twin objectivesof local accountability andof funding the best ideas,Tenovus has a uniquesystem of double scrutiny ofpotential applications inthat there are both localand national scientificadvisory committees”

Despite no new legacies this year, income is morein line with earlier years thanks to Strathclydeand Tayside Regions excelling themselves inattracting record amounts of Donations.

This has allowed us to authorise new researchprojects valued at £1,062,000, the highestamount by Tenovus Scotland in a single year.Total Interest and dividends continue at a steadylevel, notwithstanding the pittance bankers are

paying for deposits compared to the halcyon daysof yesteryear.

The financial health of Tenovus Scotland at 31March 2016 is sound and we have some£1,000,000 available for future research projects.

Mr Francis McCrossinNational Treasurer

11

Finance CommitteeAS AT 31 MARCH 2016

CHAIRMANMr F E J McCrossin COMMITTEEProfessor A A CalderProfessor J ConnellProfessor J GrieveMr M McIver OBEProfessor K PatersonMr G M Philips Mr J D Watson

All are Trustees of Tenovus Scotland

“Income is more in linewith earlier years and hasallowed us to authorise new research projects valuedat £1,062,000, the highest amount by Tenovus Scotland in asingle year”

T O D A Y ’ S R E S E A R C H ~ T O M O R R O W ’ S H E A L T H

FINANCIAL REVIEW

Set out below are the accounts for this and the preceeding five years

Income & Expenditure Accounts - £000YEAR TO 31 MARCH 2016

2015/16 2014/15 2013/14 2012/13 2011/12 2010/11

DONATIONS 754 321 618 598 227 394LEGACIES 5 73 476 140 310 488FUND RAISING 16 15 20 26 20 35INTEREST & DIVIDENDS 90 88 92 91 66 40TOTAL INCOME 865 497 1,206 855 623 957RESEARCH GRANTS 1,062 330 1,044 978 569 435ADMINISTRATION 38 37 34 32 34 35TOTAL EXPENDITURE 1,100 367 1,078 1,010 603 470SURPLUS/DEFICIT -235 130 128 -155 20 487ADMIN AS % OF INCOME 4.4% 7.5% 2.8% 3.8% 5.5% 3.6%

0

200

400

600

800

1,000

1,200

1,400

2015/16 2014/15 2013/14 2012/13 2011/12 2010/11

Income

Research Grants

Administration

Income, Research Grants & Administration Expenses - £000

97%

3%

Research Grants

Administration

Research Grants and Administration Costs 2015/16

This pie chart graphically illustrates our extremely low administration costs.

The financial information above is extracted from the full audited Annual Report and Accounts for the 6 years ended 31 March2016. Copy of the most recent audited Annual Report and Accounts is available on request from the General Secretary.

T O D A Y ’ S R E S E A R C H ~ T O M O R R O W ’ S H E A L T Hwww.tenovus-scotland.org.uk

PATRONHRH THE PRINCESS ROYAL

HON PRESIDENTSir Kenneth Calman

HON VICE PRESIDENTSLady Arbuthnott

Professor Sir Malcolm Macnaughton

TRUSTEES AND NATIONAL COMMITTEEProfessor Andrew A Calder (Chairman)

Mr Colin J Black Professor John Connell

Mrs Freda CutlerProfessor James GrieveMiss Mary Marquis MBE

Mr Francis E J McCrossin (Hon Treasurer)Mr Malcolm McIver OBE

Professor Kenneth PatersonMr Graham M Philips (Hon Secretary)

Dr Heather Reid OBE Mr James D Watson

GENERAL SECRETARYMr Iain McFadzean

OFFICEAt Royal College of Physicians and Surgeons of Glasgow

232- 242 St Vincent Street, Glasgow G2 5RJ

TELEPHONE01292 443387

EMAIL [email protected]

WEBSITE ADDRESSwww.tenovus-scotland.org.uk

AUDITORS Wylie & Bisset LLP, 168 Bath Street, Glasgow G2 4TP

BANKERSAdam & Company PLC, 238 West George Street, Glasgow G2 4QY

Clydesdale Bank PLC, 14 Bothwell Street, Glasgow G2 6QYSantander Corporate Banking, 301 St Vincent Street, Glasgow G2 5NB

STOCKBROKERSSpeirs & Jeffrey Ltd, George House, 50 George Square,Glasgow G2 1EH

CHARITY NUMBER SC 009675

If you would like to help us, online donations can be made at:www.justgiving.com/tenovusscotland

Documents

48TH ANNUAL REVIEW 2015/16 - Tenovus Scotland