New Patents . . . xl11

Compounds are disclosed of the formula See Pa- tent for Chemical Structure where R2 is unsub- stituted or substituted phenyl, R3 is lower alkyl, lower cycloalkyl or lower alkoxy lower alkyl, and L is selected from a wide variety of groups. This new class of compounds exhibit improved analgesic and anesthetic properties.

5013760

PHENYLETHYLAMINE DERIVATIVES AND

PHARMACEUTICAL USE

John B Farmer, Franci Ince, Rodney A Brown, John Dixon, Cropston, United Kingdom as- signed to Fisons plc

Phenylethylamine derivatives of the formula See Patent for Chemical Structure wherein Dl represents a phenylethyl radical which is sub- stituted with hydroxy and/or alkyl groups, Rl and R2 are hydrogen or alkyl, D2 represents hydrogen, an alkyl, or aryl group, and n is an in- teger from 3 to 5. These compounds are useful as pharmaceuticals, e.g., for treatment of cardiovascular conditions.

5013866

PHARMACEUTICAL GRADE 3,5-DIBROMOSALICYLIC ACID

AND METOHD FOR SYNTHESIZING SAME

Ton T Hai, Deanna J Nelson assigned to Baxter International Inc

An improved method of synthesizing 3,5- dibromosalicylic acid provides a highly purified pharmaceutical grade product free of toxic by- products and solvents. The purified product may be utilized as an intermediate in synthesizing pharmaceutical grade substances, as a bac- tericide when incorporated into topical oint- ments, and as an adjuvant in drug absorption systems.

5014851

PACKAGE ASSEMBLY FOR DISPENSING PHARMACEUTICAL

MEDICATIONS AND METHOD OF MANUFACTURING THE

SAME

John J Wick assigned to Multi-Comp Inc

The present invention includes a package as- sembly for dispensing pharmaceutical medica- tions, and a method of manufacturing the same. The package assembly comprises a blister sheet having blister recesses and substantially planar shoulder portions located between the recesses and coated with a cohesive composition, and a lidding sheet having one surface entirely coated with a cohesive composition having affinity for the cohesive that is coated on the shoulder por- tions of the blister sheet, but having no affinity for pharmaceutical medications positioned in the blister recesses. A relatively stiff plastic frame having top and bottom panels is positioned on opposite sides of the blister sheet and lidding sheet in a sandwich relationship, thereby giving support to the entire package assembly. The pre- sent invention, therefore, allows for customized prescription packaging to be economically hand- led by a patient’s pharmacist.

5015479

SUSTAINED RELEASE CAPSULE OR TABLET FORMULATION

COMPRISING A PHARMACEUTICALLY

ACCEPTABLE DIHYDROPYRIDINE

Seamus Mulligan, Randall T Sparks, Monks- land, GA, Ireland

A sustained release capsule or tablet formula- tion suitable for once-daily administration com- prises an adsorbate of a mixture of a pharmaceutically useful dihydropyridine and a polyvinylpyrrolidone having an average- molecular weight greater than 55,000 adsorbed on a cross-linked polyvinylpyrrolidone and blen- ded with a polymer or mixture of polymers which gel in the presence of water, the amount of said polymer or polymers being effective to pro- duce the desired sustained release effect.

5015481

STABILIZED PHARMACEUTICAL ADMMTURE COMPOSITION

Michel Franz, Michel Jans, Leo Mathur, Kam- lesh Shah, James Truelove, Brussels, Belgium as- signed to G D Searle 8z Co

A stabilized pharmaceutical composition which is an admixture of an NSAID selected from diclofenac and piroxicam, a prostaglandin and