New Patents xvii

5017597

CYCLOHEPT (B) INDOLEALKANOIC ACIDS,

PHARMACEUTICAL COMPOSITIONS AND USE

John W Gillard, Yvan Guindon, Howard E Morton, Yves Girard, Christiane Yoakim, Baie d’Urfe, Canada assigned to Merck Frosst Canada Inc

Cyclohept(b)indolealkanoic acids and acid derivatives are disclosed. The compounds act as prostaglandin and thromboxane antagonists and are useful in treating asthma, diarrhea, hypertension, angina, platelet, aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea and nephrotoxicity caused by cyclosporin A and as cytoprotective a- gents.

5017609

PHARMACEUTICAL COMPOSITION AND METHOD

OF TREATMENT OR PROPHYLAXIS OF CARDIAC

DISORDERS

Agustin Escobar, Dietmar Wagenknecht, Ah- mad W Malick assigned to E I Du Pont de Nemours and Company

A pharmaceutical composition is disclosed, which contains a short-acting beta-blocking compound of the formula See Patent for Chem- ical Structure wherein Rl may be an alkyl, cyclo- alkyl, alkenyl, alkynyl, alkyl carboxymethyl, aryl carboxymethyl, aryl or aralkyl, A may be an alkylene or alkenylene, X may be independently amino, hydrogen, halogen, hydroxy, alkoxy, aryloxy, aralkyl, cyano, amido or trifluoromethyl, n is an integer from 1 to about 4, R may be an alkyl, propargyl, dimethyl- propargyl or hydroxyalkyl; or a pharma- ceutically acceptable salt thereof in a hydroalcoholic solution further containing a physiologically acceptable buffering agent, ethanol and a physiologically acceptable liquid polyhydric compound. A method for treatment or prophylaxis of cardiac disorders using the composition of the present invention is also dis- closed.

5017703

INDOLYLPIPERIDINE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF

AND PHARMACEUTICAL COMPOSITION COMPRISING

THE SAME

Masaaki Matsuo, Takashi Manabe, Shinji Shigenaga, Hiroshi Matsuda, Toyonaka, Japan assigned to Fujisawa Pharmaceutical Company Ltd

The invention relates to novel indolylpiperidine compounds useful in the treatment of allergic disease and inflammation.

5024731

METHOD OF MANUFACTURING MATERIAL FOR MEDICAL AND PHARMACEUTICAL PRODUCTS

FROM PYROLIGNEOUS ACID

Katsum Nagata, Hisako Nagata, Matsuyama shi, Ehime ken, Japan

A method of manufacturing a material for medical and pharmaceutical products from pyroligneous acid extracted as water content in smoke generated by baking arbor and bark. Pyroligneous acid is heated, and resultant evaporation gas in a temperature range 98 degrees to 103 degrees C. is extracted and li- quified by cooling.

5024743

METHYLENDIOXY PHENATHRENE AND STILBEN DERIVATIVES, PROCESS FOR

THE PREPARATION THEREOF, PHARMACEUTICAL

COMPOSITIONS USING THESE, AND THERAPEUTIC

APPLICATIONS

Klaus Gorler, Gunter Krumbiegel, Michael Hanack, Lakshmina R Subramanian, Bergisch Gladbach, Federal Republic Of Germany as- signed to Madaus GmbH & Co