53 Symposium of International Society for Clinical ... · PDF fileOrganised by: International Society for Clinical Electrophysiology of Vision – ISCEV Slovenian Society of Ophthalmology

53rd Symposium of International Society for Clinical Electrophysiology of Vision

24–27 June 2015 Ljubljana, Slovenia

http://www.iscev2015.org/

Programme and Book of Abstracts

Organised by:International Society for Clinical Electrophysiology of Vision – ISCEV

Slovenian Society of Ophthalmology

Editors: Marko Hawlina, Jelka Brecelj (Chairs), Maja Šuštar, Martina Jarc Vidmar, Manca Tekavčič Pompe

Design: Brane Žalar

Published by: International Society for Clinical Electrophysiology of Vision - ISCEV

Slovenian Society of Ophthalmology

Printing:

CIP - Kataložni zapis o publikaciji Narodna in univerzitetna knjižnica, Ljubljana 612.84.014.42(082) 617.7(082) INTERNATIONAL Society for Clinical Electrophysiology of Vision. Symposium (53 ; 2015 ; Ljubljana) Programme and book of abstracts / 53rd Symposium of International Society for Clinical Electrophysiology of Vision, 24-27 June 2015, Ljubljana, Slovenia ; [organised by International Society for Clinical Electrophysiology of Vision - ISCEV [and] Slovenian Society of Ophthalmology ; editors Marko Hawlina ... et al.]. - Europe : International Society for Clinical Electrophysiology of Vision - ISCEV ; Ljubljana : Slovenian Society of Ophthalmology, 2015 ISBN 978-961-91886-4-4 (Slovenian Society of Ophthalmology) 1. Hawlina, Marko 2. Slovensko združenje oftalmologov 279868672

CONTENTS

Welcome Addresses .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..iii

Committees and Organisation .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..iv

Programme at a Glance.. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. ..vi

Scientific Programme . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .vii

Information for Speakers and Poster Presenters. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. xix

Registration and Fees . .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. xix

Social Programme .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .xx

General Information .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. xxi

ISCEV Conference Abstracts .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 1

Index of Authors .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. 93

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WELCOME ADDRESS Dear members, friends, newcomers!

You are warmly invited to the 53rd ISCEV Symposium to be held in Ljubljana, the capital of Slovenia, on 24–27 June 2015. We are very honoured to host the distinguished annual meeting of the Society for

Clinical Electrophysiology of Vision.

We have attended many ISCEV symposia, from our first – in Budapest in 1983 – to the most recent one, in

Boston last year, which gave us the opportunity to learn visual electrophysiology from the experts. This

experience enabled us to transfer the latest knowledge into our own routine work with the patients, as

well as encouraged our research endeavours. We sincerely hope that the mission of ISCEV 2015, which

is to present studies on ‘new findings in basic and clinical visual electrophysiology’, will attract many old

members and newcomers to share their experience and gain new knowledge. Throughout the years,

visual electrophysiology has become an important medical field, providing valuable diagnostic tools.

Nowadays, it is dealt with in ophthalmological textbooks and is relevant to many basic physiological,

pharmacological and veterinary aspects. Furthermore, electroretinography has been included in

neurological recommendations of the International Federation of Clinical Neurophysiology (IFCN). We

plan to devote one day of our Symposium, Wednesday, 24 June, to a joint meeting with the European

Neuroophthalmological Society (EUNOS) and thus create new opportunity for presentation of topics

that are relevant to both societies.

We shall do our best to assure the Ljubljana ISCEV Symposium provides you with new scientific and

practical knowledge, enrich you with a variety of new social contacts, and, as much as possible, also

with the beauties of Slovenian culture and country. We do hope you will leave Ljubljana with the same

good feelings and memories as we have cherished after attending the previous Symposia.

We look forward to welcoming you!

Marko Hawlina and Jelka Brecelj

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COMMITTEES AND ORGANISATIONHonorary Committee

Tine S Prevec

Martin Štrucl

Hisako Ikeda

Colin Barber

Günter Niemeyer

Eberhart Zrenner

Organising Committee

Marko Hawlina (Chair)

Jelka Brecelj (Chair)

Martina Jarc-Vidmar

Manca Tekavčič-Pompe

Maja Šuštar

Zoran Rodi

Scientific Committee:

Jelka Brecelj

Scott Brodie

Marko Hawlina

Karen Holopigian

Zoran Rodi

Branka Stirn-Kranjc

Invited Speakers

Adachi Lecture: Richard Weleber, USA

Metabolic Disease with Choroidal Atrophy: Gyrate Atrophy and LCHADD

Dawson Lecture: Graham E. Holder, United Kingdom

The Role of Visual Electrophysiology in Neuro-ophthalmology.

Congress Secretariat

CANKARJEV DOM, Cultural and Congress Centre

Mrs. Alenka Kregar

Prešernova 10, SI-1000 Ljubljana, Slovenia

Phone: +386 1 24 17 133 Fax: +386 1 24 17 296 E-mail: [email protected]

Venue

Cankarjev dom, Cultural and Congress Centre

Prešernova 10, SI-1000 Ljubljana, Slovenia

Phone: +386 1 241 7100 Fax: +386 1 241 7296

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ACKNOWLEDGEMENTSThe Organising Committee is deeply appreciative of the sponsorship generously provided by the following companies:

General Sponsor

Golden Sponsor

Silver Sponsors

Bronze Sponsor

Exhibitor

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PROGRAMME AT A GLANCETime Sunday, June 21 Monday, June 22 Tuesday, June 23 Wednesday, June 24 Thursday, June 25 Friday, June 26 Saturday, June 277:30 EUNOS EUNOS EUNOS EUNOS/ISCEV ISCEV ISCEV ISCEV

9:00

Headache and

intracranial hypertension

JayKeslerDigre

Research Ctee

Symposium Trauzettel Klosinski

ISCEVCase

ReportsSession

PaperSession

2Retinal &

Optic NerveFunction &Treatment

PaperSession

5

Toxicology &Treatment

PaperSession

8Retinal

Function &Structure

9:30

10:00

Coffee break 10:30 Coffee break Coffee break

Congress Opening Coffee break

Coffee break Coffee break11:00

Registration

Eye movements

and Pupil Kennard

AntoniadesZrennerBremner

Mitochondrial

diseasesSymposium Yu Wai Man

W. DawsonMemorial

LectureG.E. Holder

Introductory Lecture

D. McCullochPaper

Session6

RetinalDiseases

Dodt &MarmorAward

11:30 Paper

Session3

PediatricElectrophysiology

12:00 PaperSessionEUNOS

Electrophysiology

Congress Closing

Lunch

12:30

Buffet Lunchwith Posters

1

Buffet Lunchwith Posters

213:00

Lunch

Lunch

Lunch

Symposiumwith Sponsors

13:30

14:00

Course 1Eye Movements

KennardAntoniadesJi-Soo Kim

Pediatric Neuro-Ophthalmological

SymposiumLandau,

Brodsky, Gottlob, Leiba, Gerth Kahlert

Illusisons,Hallucinations,

Neglect andRehabilitation

Plant, Malhotra,Trauzettel Klosinski,

Rowe

14:30

Joint PosterSession 1

EUNOS/ISCEV

Poster

Session 2

Introductory L.P. Lachapelle

15:00 PaperSession

7Animal Electrophy.

ISCEVOlympics& Picnic

Lake Bled

15:30 Coffee break Coffee break

Coffee break Coffee break

Coffee break

16:00 Course 2

ElectrophysiologyHolder, Hawlina,

Brecelj

Optic Neuropathies IArnold: NAION

Arndt: TC in NAIONFrederiksen: ON

Hickman: Phenytoin

Optic Neuropathies IIHedges: GCCDotan: Toxic

Akdal: BehcetDe Keizer: Orbit

Introductory LectureR. Weleber

PaperSession

4

Methodologicalaspects of

Electrophysiology

Coffee break

Membership

Meeting

16:30 ISCEV PaperSession

1Neuro-

Ophthalmology

17:00

17:30 Break

Controversy debateUS or biopsy in GCA

Landau vs. Jay

Course 3

NystagmusGottlob,

Proudlock, Pilat, McLean

18:00Membership

Meeting

Group photo

Freeevening

18:30 Group photo

Freeevening

19:00 AdachiAward

LectureR. Weleber

19:30

Freeevening

20:00 Opening and

Welcome Party

Club CD

ISCEVWelcomeReceptionLjubljana

CastleEUNOS

Conference Dinner

ISCEVConference

DinnerClub CD

20:30

21:00

21:30

22:00

ISCEV COURSESMonday, June 22, 2015 8:30 – 17:30

Tuesday, June 23, 2015 8:30 – 16:00

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ISCEV COURSES TIMETABLE

Monday, June 22, 2015Human Course – Hall M3,4 Animal Course – Hall M3,4

08:30 – 08:45 Introduction to the course, faculty, expectations and structure

Dorothy Thompson

08:45 – 09:30 Introduction to full field ERGs

Suresh Viswanathan

Physiology of ERGs ( Basic components, Cellular sources, Functional relationships (Naka-Rushton))

ISCEV Full field ERG Standard (Recording protocols and their physiological basis)

Additional diagnostic resources (a-wave modelling, PhNR, On-Off-, chromatic and S-cone stimulation)

09:30 – 10:15 Clinical application of full field ERG

Tony Robson

Interpreting ISCEV Full field standard ERGs (Patterns of change to track down the underlying pathophysiology)

Diagnostic challenges in health and disease (Distinguishing rod and cone photoreceptor contributions, limited vs. generalised disease, negative ERGs)

Human Course – Hall M3,4 Animal Course – Hall M2

10:15 – 10:45 Coffee break

10:45 – 11:30 Techniques to localise retinal stimulation PERG & mfERG Imaging (practical demonstration)

Michael Bach Travel to demonstration site – Medical Faculty

11:30 – 12:15 Clinical application of mfERG and PERG Imaging (practical demonstration)

Tony Robson Mathias Seeliger + faculty

Demonstrations of SLO/OCT experimental in vivo imaging

12:15 – 13:00 Sandwich lunch

13:00 – 13:30 Techniques of VEP recording Imaging (practical demonstration)

Michael Bach Travel from demonstration site (extd. lunch) – Medical Faculty

13:30– 14:10 Clinical applications of the VEP Preclinical imaging (OCT, SLO)

Jelka Brecelj Mathias Seeliger

OCT, SLO & angiography as structural biomarkers, preclinical models & therapeutic interventions

14:10 – 14:35 EOG recording and its clinical applications ERG in retinal research 1 (inner retina)

Dorothy Thompson Suresh Viswanathan

14:35 – 15:00 Non-standard ERGs (red flash & S-cone) Experimental use of ERG, PHNR& PERG with focus on Glaucoma & ON disease in rats & large animals Chris Hogg


15:30 – 16:15 Recognising everyday common artefacts ERG in retinal research 2 (outer retina)

Ruth Hamilton Mathias Seeliger

Experimental use of ERG in inherited diseases affecting RPE, photoreceptors and bipolar cellst

16:15 – 17:30 Clinical practical demonstrations – Second Foyer Extraction of specific ERG components

Dorothy Thompson, Tony Robson, Chris Hogg, Manca Tekavcic Pompe, Ruth Hamilton, Maja Šuštar

Christoph Friedburg

6 equipment stations demonstrating

1) Full field ERG

2) MfERG/PERG

3) PERG/PVEP

& range of electrodes: DTL, GF, HK loop, skin

Approaches to unravel rod and cone contributions to the ERG via methods, like a-wave analysis and paired flash paradigms

19:00 Course dinner with faculty

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Tuesday, June 23, 2015Human Course – Hall M3,4 Animal Course – Hall M3,4

08:30 – 09:00 A diagnostic approach to retinal disorders

Tony Robson

09:00 – 09:40 Part 1: Experimental ERG in the discovery of novel aspects of retinal function & pathophysiology

Mineo Kondo

Experimental ERG in the discovery of novel aspects of retinal function

Diagnostic insights to better understand the underlying pathophysiology

09:45 – 10:15 Part 2: ERG in Preclinical Therapy Assessment

Mathias Seeliger

ERG recordings as functional biomarker

Follow up of therapeutic interventions in pre-clinical models of rod (RP) and cone (ACHM2) disease



10:45 – 11:05 Maturation of visual electrophysiological measures Fundamentals of ERG in animal models

Ruth Hamilton Bo Lei

Recording in animals (equipment and materials)

‘ISCEV’ standard (basic and extended tests)

11:05 – 11:25 The chiasm and the VEP ERG (practical demonstrations)

albinism /achiasmia Mathias Seeliger & faculty

Jelka Brecelj ERG demonstrations with a rodent phantom

(light-sensitive, “artificial” mouse/ra)11:30 – 12:15 Paediatric techniques in an outpatient setting

Dorothy Thompson

12:15 – 13:00 Sandwich lunch

Hall M3,4

13:00 – 14:00 System overview and calibration

Chris Hogg

What do I need to do to set up a lab

General considerations (shielded room, isolation, power cables, accessibility)

Scope of diagnostics (which test equipment, which age group)

Equipment comparison

What do I need to know before I buy?

Technical considerations (amplifiers, filters, flexibility of programming, stimulators, external triggers)

How to make a dummy patient photocell

Equipment questionnaire


14:00 – 15:00 Comprehensive clinical visual electrodiagnostics Comprehensive animal diagnostics

Graham Holder Mathias Seeliger, Bo Lei, Suresh Viswanathan

An overview and integration of the clinical test findings Complementary phenotyping of animal models based on ERG and imaging techniques


15:30 – 16:00 Time with manufacturers Time with imaging manufacturers

Comparison of specifications & practise Comparison of specifications & practise

16:00 Course finish and feedback

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ISCEV CONFERENCE TIMETABLE

53rd ISCEV Symposium and 12th EUNOS Congress joint dayWednesday, June 24, 2015Linhart hall

09:00 – 10:15 Case reports session

Moderators: Michael Marmor, Richard Smith


10:45 – 11:00 Opening ceremony of the congress

11:00 – 11:50 William Dawson memorial lecture

Electrophysiology in neuro-ophthalmology

Graham E. Holder (UNITED KINGDOM)

Introduction: Marko Hawlina (SLOVENIA)

11:50 – 13:00 Electrophysiology - EUNOS

Moderators: Shuichi Yamamoto, Eberhart Zrenner

11:50 Introductory lecture: Current status of microelectronic aids in fighting blindness

Eberhart Zrenner (GERMANY)

12:20 Follow-up of a new automated perimetry protocol based on the multifocal ERG compared to the G2 perimetry

Livia Brandao, Matthias Monhart, Andreas Schötzau, Anna Ledolter, Anja Palmowski-Wolfe (SWITZERLAND)

12:30 Multifocal visual evoked potentials in patients with optic disc drusen

Lasse Malmqvist, Clare Fraser, Luis De Santiago, Alexander Klistorner, Steffen Hamann (DENMARK)

12:40 Presumable persistent placoid maculopathy: A case report after 1-year follow-up with

multimodal imaging and electroretinography

Andre Messias, Katharina Messias, Fernanda Crotti, Rogério Costa (BRAZIL)

12:50 Retrograde maculopathy

Mathias Abegg (SWITZERLAND)

13:00 – 13:10 Break

13:10 – 14:30 Lunch symposium with sponsors

Moderators: Jorge Arruga Ginebreda (SPAIN), Mathias Seeliger (GERMANY)

13:10 Clinical experience with Idebenone (Raxone®) in the treatment of patients with Leber’s hereditary optic neuropathy (LHON) Günther Metz, Santhera (SWITZERLAND)

13:20 Identification of aqueous and lipid deficient dry eye - Optive Family of Allergan Špela Štunf, Eye Hospital, University Medical Centre Ljubljana (SLOVENIA)

13:30 Innovations in the Roland Product line Joachim Finger, Roland Consult (GERMANY)

13:40 About animal research with RETImap ERG, mf ERG OCT, AF results and technique M. M. Mai, Roland Consult (GERMANY)

13:50 New developments in animal testing Diagnosys Ltd. (UNITED KINGDOM)

14:00 LKC RETeval and it's use around the world James J. Datovech, LKC Technologies Inc. (UNITED STATES)

14:10 CSO-Advanced diagnostic systems in ophthalmology Claudio Baglini, CSO, Florence (ITALY)

14:20 Discussion

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14:30 – 15:30 Poster session 1 - Neuro-ophthalmology - Poster/Second foyer

Moderators: Martina Jarc-Vidmar, Manca Tekavcic-Pompe, Anthony G. Robson

P01 Longitudinal study of retinal and optic nerve function in patients with multiple sclerosis – a baseline report

Christina Gerth-Kahlert, Klara Landau, James V.M. Hanson (SWITZERLAND)

P02 Visual evoked potentials in ON-pathway disorders

Dennis Fritsch, Valeria Ricotti, Francesco Muntoni, Stephanie Grunewald, Jane Sowden, Dorothy Thompson (UNITED KINGDOM)

P03A BOLD venture: comparison of VEP with functional near-infrared spectroscopy and functional magnetic resonance imaging for assessment of visual acuity

Torsten Straßer, Dominic Hillerkuss, Lukasz Lisowski, Sabrina Schneider, Florian Häußinger, Michael Erb, Andreas J. Fallgatter, Klaus Scheffler, Eberhart Zrenner, Ditta Zobor (GERMANY)

P04 A case of optic atrophy and retinal degeneration with low mitochondrial respiratory enzyme V activity

Hiroko Yamazaki, Yuzhu Chai, Yasushi Ooya (JAPAN)

P05 Electrophysiologic analysis of visual complications, specifically optic atrophy, from graft vs host disease

Stephanie Lao, Margaret C. Hubbell, Amanda Selchau, Terry Wood (UNITED STATES)

P06 Comparison of electroretinographical responses in albinism, idiopathic infantile nystagmus and healthy controls

Zhanhan Tu, Christopher Degg, Viral Sheth, Irene Gottlob, Frank Proudlock (UNITED KINGDOM)

P07 Vitamin A deficiency retinopathy: one year follow up

Evelyn Longhin, Elisabetta Pilotto, Enrica Convento, Alma Patrizia Tormene, Edoardo Midena (ITALY)

P08Clinical case: multifocal ERG demonstrates residual abnormality years after traumatic macular injury in an eye with 20/20 vision

Linden Doss, Terry Wood (UNITED STATES)

P09 High-resolution imaging of patients with Bietti crystalline dystrophy with CYP4V2 mutation

Kiyoko Gocho, Shuhei Kameya, Keiichiro Akeo, Sachiko Kikuchi, Ayumi Usui, Kunihiko Yamaki, Takaaki Hayashi, Hiroshi Tsuneoka, Atsushi Mizota, Hiroshi Takahashi (JAPAN)

14:30 – 15:30 Poster session 1 - Inner retinal function and the optic nerve – Poster/Second foyer


P10 Functional and structural characteristics of early glaucoma

Maja Šuštar, Darko Perovšek, Barbara Cvenkel (SLOVENIA)

P11 Can variability of pattern ERG signal help to detect retinal ganglion cells dysfunction in glaucomatous eyes?

Alberto Mavilio, Francesca Scrimieri, Donato Errico (ITALY)

P12 Comparison of pattern ERG and focal macular PhNR to evaluate the ganglion cell function

Souichi Matsumoto, Kazuma Yagura, Kei Shinoda, Harue Matsumoto, Atsushi Mizota (JAPAN)

P13Functional assessment of pre-ganglion and ganglion cell level in autosomal dominant optic atrophy by PERGLA, PERG and MULTIFOCAL ERG

Gabriella Cammarata, Gemma Tremolada, Paola Ciasca, Chiara Manclossi, Costanza Lamperti, Eleonora Lamantea, Stefania Bianchi Marzoli (ITALY)

P14 Red-blue pupil reaction and the melanotic ganglion cell response

Audrey Chia, Daniel Kai Peng Chua, Li Yu Chen, Rena Png (SINGAPORE)

14:30 – 15:30 Poster session 1 – Pediatric electrophysiology – Poster/Second foyer


P15 Paediatric electrodiagnosis in Hong Kong

Carol Po-Sang Lam, Winnie Wai Ying Lau, Carmen Kar Mun Chan, Andrew Chung Tin Fok (HONG KONG)

P16 Electroretinogram changes in retinopathy of prematurity after photocoagulation

Hongbo Cheng, Guoming Zhang, Feng Wen, Shizhou Huang, Dezheng Wu (CHINA)

P17 Evaluation of visual function by visual evoked potentials prior to surgery for congenital cataract

Hande Taylan Sekeroglu, Kadriye Erkan Turan, Ali Sefik Sanac (TURKEY)

P18Comparison between ERG after photocoagulation and ERG after intravitreal injection of ranibizumab for treating retinopathy of prematurity

Guoming Zhang, Hongbo Cheng, Jun Mei, Linli Wang, Honghui He (CHINA)

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P19Electroretinograms in idiopathic infantile nystagmus, optic nerve hypoplasia, and albinism, in comparison to healthy controls and early-onset retinal dystrophies

Alma Kurent, Branka Stirn-Kranjc, Jelka Brecelj (SLOVENIA)

14:30 – 15:30 Poster session 1 – Toxicology and treatment - Poster/Second foyer


P20 Aripiprazole induced chorioretinopathy

Matthieu Robert, Isabelle Audo, Christina Zeitz, Jean-Bernard Letessier, Celine Faure (FRANCE)

P21 Photopic response before and after vitreous removal during vitreous surgery

Kei Shinoda, Soiti Matsumoto, Gaku Terauchi, Goichi Akiyama, Harue Matsumoto, Atsushi Mizota, Yozo Miyake (JAPAN)

P22 MfERG assessment of hydroxychloroquine toxicity

Enid Chelva, Monika Dolliver, Sarina Laurin, Terri Mclaren, John De Roach (AUSTRALIA)

P23 Multifocal ERG analysis of primary CNS lymphoma with ocular manifestations

Margaret Hubbell, Amanda Selchau, Stephanie Lao, John Hamilton, Mark Pennesi, Terry Wood (UNITED STATES)

P24 Retinal functional changes associated with anti- VEGF treatment in subjects with wet ARMD

Güliz Fatma Yavas, Tuncay Kusbeci, Umit Ubeyt Inan (TURKEY)

P25 Insidious hydroxychloroquine macular toxicity: a case report

Livia Brandao, Anja Palmowski-Wolfe (SWITZERLAND)


16:00 – 18:00 Paper session 1 – Neuro-ophthalmology – Oral/Linhart hall

Moderators: Graham E. Holder, Marko Hawlina

16:00 Introductory lecture: Paraneoplastic and autoimmune retinopathy

Richard Weleber (UNITED STATES)

16:30Retrospective analysis of the progression of electrophysiological changes after the first visual symptoms in juvenile onset optic neuritis

Márta Janáky, Imre Fejes, Rita Alács, György Benedek, Gábor Braunitzer (HUNGARY)

16:45 Visual pathways in humans with ephrin-B1 deficiency

Michael Hoffmann, Hagen Thieme, Karin Liedecke, Synke Meltendorf, Juliane Reupsch, Martin Zenker, Ilse Wieland (GERMANY)

17:00 Genetic associations to the ERG in autism spectrum disorder

Paul Constable, Sebastian Gaigg, Dermot Bowler, Dorothy Thompson (UNITED KINGDOM)

17:15 Structural and functional effects of dysmyelination in a large animal model

James Verhoeve, Michael Nork, Leandro Teixeira, Richard Dubielzig, Abigail Radcliff, Ian Duncan (UNITED STATES)

17:30 Naso-temporal thickness of the retinal ganglion cell layer by OCT-segmentation in lesions of the visual pathway

Hannes G. H. Wildberger, Werner Wichmann, Klara Landau, Luca Regli, Christina Gerth-Kahlert (SWITZERLAND)

17:45Evidence for compartment syndrome damage in a primate model of non-arteritic anterior ischemic optic neuropathy (pNAION)

Mary Johnson, Neil Miller, Steven Bernstein (UNITED STATES)

20:00 – 23:00 Welcome reception/Ljubljana castle (together with EUNOS)

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EUNOS Poster session 3Electrophysiology, toxic states, methods (Second foyer) Moderators: Gabriella Szatmary (UNITED STATES), Jan Willem Pott (NETHERLANDS), Anja Palmowski-Wolfe (SWITZERLAND)

PE094 Comparison of electroretinographical responses in albinism, idiopathic infantile nystagmus and healthy controls Zhanhan Tu, Christopher Degg, Viral Sheth, Irene Gottlob, Frank Proudlock (UNITED KINGDOM)

PE095 Retinal ganglion cell volume correlates with pattern electroretinogram in acute optic neuritis Justin Mckee, Charles Cottriall, John Elston, Lars Fugger, Chris Kennard, Nikos Evangelou, Jacqueline Palace, Matthew Craner (UNITED KINGDOM)

PE96 Methanol toxicity: Bangladesh perspective Sarwat Rahman (BANGLADESH)

PE97 Ketamine affects single vesicle exocytosis in cultured rat astrocytes Eva Lasič, Matjaž Stenovec, Mićo Božić, Saša Trkov, Marko Kreft, Vladimir Grubišić, Vladimir Parpura, Robert Zorec (SLOVENIA)

PE98 Tamoxifen-induced optic neuropathy or NAION? Idit Maharshak (ISRAEL)

PE99 Intracellular cAMP and Ca2+ signalling in cultured rat astrocytes Anemari Horvat, Nina Vardjan, Robert Zorec (SLOVENIA)

PE100 Low vision in multiple sclerosis Andreia Soares, João Cerqueira, Cristina Almeida, Fernando Vaz (PORTUGAL)

PE101 Novel update 2015: It is more than a library Kathleen Digre, Nancy Lombardo, Chrisy Jarvis, Valerie Biousse, Aki Kawasaki (UNITED STATES)

PE102 Use of non-mydriatic wide-field retinography for periphlebitis detection in patients with multiple sclerosis Ruben Torres-Torres, Elena Fraga-Pumar, Elena H. Martínez-Lapiscina, Pablo Villoslada, Bernardo F. Sanchez-Dalmau (SPAIN)

PE103 Visual dysfunction induced by cobalt toxicity Bernardo Sanchez Dalmau, Amélia Maria De Carvalho, Cristina Nieto, Christian Fontecilla, Ruben Torres Torres, Santiago Nogués, Jenaro Angel Fernández-Valencia (SPAIN)

PE104 Quantification of retinal ganglion cell loss detected by spectral domain optical coherence tomography in patients with stroke Stefania Bianchi Marzoli, Lisa Melzi, Ciasca Paola, Gabriella Cammarata, Carlotta Casati, Giuseppe Vallar, Nadia Bolognini (ITALY)

PE105 Abnormal optic nerve head morphology in albinism imaged using high resolution spectral domain optical coherence tomography Frank Proudlock, Sarim Mohammad, Viral Sheth, Anastasia Pilat, Helena Lee, Ellen Pollheimer, Irene Gottlob (UNITED KINGDOM)

PE106 High resolution imaging of the optic nerve and retina in optic nerve hypoplasia Anastasia Pilat, Daniel Sibley, Rebecca McLean, Frank Proudlock, Irene Gottlob (UNITED KINGDOM)

PE107 A prospective study on the prevalence of microcystic macular changes on optical coherence tomography of the macular region in optic nerve atrophy of non-neuritis origin Jan Willem Pott, Willemien De Vries, Axel Petzold (NETHERLANDS)

PE108 Analysis of the macular ganglion cell layer of patients with vascular lesions of the posterior pathway Rita Anjos, André Vicente, Livio Costa, Arnaldo Santos, Duarte Amado, Joana Ferreira, João Paulo Cunha (PORTUGAL)

PE109 Unusual acquired temporal sectoral scotomas M.J. Gilhooley, Clare Fraser, Gordon T. Plant (UNITED KINGDOM)

PE110 The role of B-cells in early onset acute optic neuritis Ruth Huna-Baron, Anna Feldman, Michael Gurevich, Anat Achiron (ISRAEL)

PE111 Unilateral optic neuritis and venous sinus thrombosis related to myelin-oligodendrocyte glycoprotein antibodies: A case report Maribel Acuna Salles, Pedro Pascual Ruiz, Laura Cabrejas Martínez, Miguel Ángel Alonso Peralta, Viviana Lezcano Carduz, Cristina Molero Langa (SPAIN)

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PE112 Adult malignant optic pathway glioma mimics a bilateral sequential anterior ischaemic optic neuropathy Viviana Lezcano Carduz, Miguel Ángel Alonso Peralta, Cristina Molero Langa, Maribel Acuña Salles, Laura Cabrejas Martinez (SPAIN)

PE113 Changes in macular layers in the early course of non-arteritic ischaemic optic neuropathy Bernardo Sanchez Dalmau, Johannes Keller, Pablo Villoslada (SPAIN)

PE114 Steroid-dependent autoimmune optic neuropathy: Case series Ainat Klein, Anat Kesler (ISRAEL)

PE115 Association of 25-hydroxyvitamin D levels with RNFL and GCL thickness and clinical tests of visual function in acute optic neuritis Gorm Pihl-Jensen, Kiren Farooq, Jette Frederiksen (DENMARK)

PE116 The time course of retinal ganglion cell layer loss after non-arteritic anterior ischaemic optic neuropathy Bao-Khanh Tran, François-Xavier Borruat (SWITZERLAND)

PE117 My wife says I can´t drive … Mónica Loureiro, Lígia Ribeiro, David Tente, António Figueiredo Lopes, Óscar Alves, Dália Meira (PORTUGAL)

PE118 Retrobulbar optic neuritis in neuroborreliosis: A case report Monika Sarnat-Kucharczyk, Dorota Pojda-Wilczek, Ewa Mrukwa-Kominek (POLAND)

Thursday, June 25, 2015Linhart hall

09:00 – 10:45 Paper session 2 – Retinal and optic nerve function and treatment – Oral

Moderators: Márta Janáky, Enid Chelva

09:00 Detecting glaucoma with photopic negative response

Marta Kiszkielis, Wojciech Lubiński, Krzysztof Penkala (POLAND)

09:15 Exploring the methods of data analysis in multi focal visual evoked potentials (mfVEP)

Lasse Malmqvist, Clare Fraser, Luis De Santiago, Alexander Klistorner, Steffen Hamann (DENMARK)

09:30 Interocular difference of retinal ganglion cell function measured by objective and subjective methods

Imre Fejes, Péter Balázs Kocsis, Márta Janáky (HUNGARY)

09:45 Electrophysiology and colour: a comparison of methods to evaluate inner retinal function

Anne Kurtenbach, Christoph Kernstock, Eberhart Zrenner, Hana Langrová (GERMANY)

10:00 Electroretinographic evidence supportive of an organic cause in some forms of functional amblyopia

Raquel Beneish, Allison Dorfman, Ayesha Khan, Robert Polomeno, Robert Koenekoop, Pierre Lachapelle (CANADA)

10:15 Quality and quantity of rescue in retinal gene therapy: implications for vision

Mathias Seeliger, Vithiyanjali Sothilingam, Naoyuki Tanimoto, Marina Garcia Garrido, Susanne C Beck, Christian Schoen, Martin Biel, Stylianos Michalakis, Regine Mühlfriedel (GERMANY)

10:30 Treatment with transcorneal electric stimulation (TES) in hereditary retinal degeneration

Eberhart Zrenner, Florian Gekeler, Mariya Gosheva, Andreas Schatz (GERMANY)


11:15 – 13:00 Paper session 3 – Pediatric electrophysiology – Oral

Moderators: Dorothy Thompson, Jelka Brecelj

11:15 Introductory lecture: Electrophysiologic exploration of early visual development in human infants

Daphne L. McCulloch (CANADA)

11:45 Retinal dystrophy in young patients presenting as refractory intermediate uveitis

Ymkje Marije Hettinga, Maria van Genderen, Wietse Wieringa, Annette Ossewaarde, Joke De Boer (NETHERLANDS)

xiv

12:00 Decreased foveal function causing faster myopic progression in children

Serena Zhe Chuang Li, Allen Ming Yan Cheong, Chea Su Kee, Henry Ho Lung Chan (CHINA)

12:15 Electrophysiological evaluation of superior and inferior visual fields in healthy schoolchildren

Manca Tekavcic Pompe, Maja Šuštar, Branka Stirn Kranjc, Jelka Brecelj, Katja Groleger Sršen (SLOVENIA)

12:30 Flash VEP in children with meningitis

Raman Prasad Sah, Jyoti Baba Shrestha (NEPAL)

12:45Follow-up of electroretinogram and visual evoked potentials as markers of retinal dystrophy and phenotype-genotype relationship in a large sample of children affected by Joubert syndrome

Alice Tarantola, Giulio Ruberto, Enza Maria Valente, Chiara Bertone, Mauro Antonini, Sabrina Signorini, Carmine Tinelli, Umberto Balottin, Paolo Emilio Bianchi (ITALY)

13:00 – 14:30 Lunch

14:30 – 15:30 Poster session 2 – Methodological aspects of electrophysiology – Poster/Second foyer

Moderators: Ruth Hamilton, Mineo Kondo, Serge G. Rosolen

P26 Four decades of visual electrophysiology in Slovenia

Jelka Brecelj (SLOVENIA)

P27 LED-based tunable light source for visual electrophysiology

Gregor Belušič, Marko Ilić, Katja Horvat, Primož Pirih (SLOVENIA)

P28 Scotopic red ERG findings

Li Yu Chen, Rena Png, Ranjana Mathur, Audrey Chia (SINGAPORE)

P29 Multi-stage ANC filter applied to mfVEP recordings

Miguel Ortiz, Luis De Santiago, Luciano Boquete, Román Blanco (SPAIN)

P30Using a novel electrode based on a super absorbent polymer for preparation-free recording of visual evoked potentials

Susanne Kramer, Torsten Strasser, Tobias Peters, Eberhart Zrenner (GERMANY)

P31 Recording the steady-state pattern ERG responses using lock-in amplifier

Kazuma Yagura, Soiti Matsumoto, Kei Shinoda, Harue Matsumoto, Atsushi Mizota (JAPAN)

P32Grouped responses of multifocal visual evoked potentials and their sensitivity in the detection of simulated visual field defects

Maja Šuštar, Jelka Brecelj (SLOVENIA)

14:30 – 15:30 Poster session 2 – Retinal diseases – Poster/Second foyer


P33 A case of peripheral cone dystrophy with different cone dysfunction on each eye

Rei Arai, Yujin Mochizuki, Nobuo Ishida, Atsushi Mizota, Nobuyuki Ebihara (JAPAN)

P34 Electroretinographic follow-up in cone and cone–rod dystrophies

Cornelia Andreea Corici, Maja Šuštar, Martina Jarc-Vidmar, Branka Stirn-Kranjc, Marko Hawlina, Jelka Brecelj (SLOVENIA)

P35 Retina-wide disease and foveal sparing in ABCA4-related retinopathy

Ana Fakin, Anthony G. Robson, Kaoru Fujinami, Anthony T. Moore, Andrew R. Webster, Michel Michaelides, Graham E. Holder (UNITED KINGDOM)

P36 Clinical and genetic characteristics of a Japanese family with autosomal dominant retinitis pigments

Miki Hata, Kaoru Fujinami, Takeshi Iwata, Toru Noda, Kazushige Tsunoda (JAPAN)

P37 Characteristics of global flash mfERG in patients with retinitis pigmentosa

Christie Hang I Lam, Serena Zhe Chuang Li, Man Pan Chin, Henry Ho Lung Chan (HONG KONG)

P38 Foveal hypoplasia and atypical retinitis pigmentosa in a family: clinical phenotype and genetic investigations

Ajoy Vincent, Heather Macdonald, Jeffrey Locke, Anupreet Tumber, Carol Westall, Elise Heon (CANADA)

P39 Clinical and electrophysiological findings in two siblings with mutations in the USH2A gene

Eva Lenassi, Maria Bitner-Glindzicz, Linda M. Luxon, Graham E. Holder, Andrew R. Webster, Anthony G. Robson (UNITED KINGDOM)

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P40 Analysis of patients with electronegative b-waves (2008–2014): a case series

Ranjana Mathur, Li Yu Chen, Rena Png, Gemmy Cheung Cm, Audrey Chia (SINGAPORE)

P41 Geographic atrophy secondary to age-related macular degeneration: functional and morphological evaluation

Elisabetta Pilotto, Evelyn Longhin, Francesca Guidolin, Enrica Convento, Alma Patrizia Tormene, Edoardo Midena (ITALY)

P42 Autoimmune retinopathy in the fellow eye 10 years after initial presentation

Takehito Iwase, Yosuhe Nakamura, Gen Miura, Hisao Ode, Atsuhiro Kanda, Wataru Saito, Shuichi Yamamoto (JAPAN)

P43 Maculopathy following exposure to visible and infra-red laser radiation

James Hanson, Julian Sromicki, Mario Mangold, Matthias Golling, Christina Gerth-Kahlert (SWITZERLAND)

P44 Clinical and electrodiagnostic findings in a family with autosomal dominant RGR mutation

Monique Leys, J. Vernon Odom, Xinjing Wang (UNITED STATES)

P45 Why am I losing my vision? LORD or something else. A case report

Rena Png, Ranjana Mathur, Edmund YM Wong (SINGAPORE)

14:30 – 15:30 Poster session 2 – Animal electrophysiology – Poster/Second foyer


P46 Comparison of waveforms of the scotopic threshold response elicited by different methods of stimulation

Takako Hidaka, Hideki Chuman, Nobuhisa Nao-I (JAPAN)

P47Pivotal roles of Fezf2 in differentiation of cone OFF bipolar cells and functional maturation of cone ON bipolar cells in retina

Yujin Mochizuki, Atsushi Mizota, Sumiko Watanabe, Nobuyuki Ebihara (JAPAN)

P48 Assessment of the pupillary light reflex in monkey using a new portable device designed for clinical use

Serge Rosolen, Nadège Sarrazin, Youssef Lourhzal, Pierre Moissonnier, Sophie Gilardeau, Cedric Lamirel, Pierre Pouget, Jean Lorenceau, Anne Baron-Van Evercooren, Serge Picaud (FRANCE)

14:30 – 15:30 Poster session 2 – Retinal function and structure – Poster/Second foyer


P49»En face« spectral domain optical coherence tomography compared with functional tests in patients treated with anti-malarial drugs

Carl Arndt, Mathieu Costantini, Sylvie Berthemy, Alain Ducasse, Christophe Chiquet, Martine Mauget (FRANCE)

P50 Multimodal imaging of a case of peripheral cone dystrophy

Shuhei Kameya, Naoko Ito, Kiyoko Gocho, Takaaki Hayashi, Sachiko Kikuchi, Satoshi Katagiri, Tamaki Gekka, Kunihiko Yamaki, Hiroshi Takahashi, Hiroshi Tsuneoka (JAPAN)

P51Simultaneous recording of electroretinography and visual evoked potential in normal subjects and patients with vitreous hemorrhage

Young-Hoon Ohn, Tae Kwann Park, Hoon Dong Kim, Yoon Kyung Kim, Jung Woo Han (REPUBLIC OF KOREA)

P52 The effect of sustained bedrest and hypoxia on electroretinographic responses

Maja Potrč, Maja Šuštar, Polona Jaki-Mekjavić, Marko Hawlina, Ola Eiken, Igor Mekjavić (SLOVENIA)

P53 Screening of cone dysfunction by the RETeval (TM) handheld ERG device

Soichiro Tamaki, Natsuko Nakamura, Kaoru Fujinami, Yoshinobu Mizuno, Toru Noda, Yozo Miyake, Kazushige Tsunoda (JAPAN)


16:00 – 18:15 Paper session 4 – Methodological aspects of electrophysiology – Oral

Moderators: Daphne L. McCulloch, Michael Bach

16:00 Plagiarism dangers lurking in scientific publishing

Michael Bach (GERMANY)

16:15 Effect of shorter dark-adaptation on ISCEV standard ERGs and an exploration of the dark-adapted red flash ERG

Ruth Hamilton, Kirsten Graham (UNITED KINGDOM)

16:30 Comparison between two types of skin electrode ERG recording system

Atsuhiro Tanikawa, Iyo Ueda, Ryota Sakurai, Yoshiaki Shimada, Masayuki Horiguchi (JAPAN)

16:45 Effect of cataract on flicker electroretinogram (ERG) recorded with RETeval

Takayuki Koike, Yosuke Nakamura, Junki Azuma, Yumi Tanaka, Gen Miura, Takeshi Sugawara, Shuichi Yamamoto (JAPAN)

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17:00 Functional imaging of the retina with multi-angular electroretinography (maERG)

Antoine Brassard Simard, Mathieu Gauvin, Bing Yu Chen, Pierre Lachapelle, Jean-Marc Lina (CANADA)

17:15Effect of pupil size on flicker ERGs recorded with RETeval System: experiments using mydriatics and artificial pupils

Mineo Kondo, Kumiko Kato, Masahiko Sugimoto, Kengo Ikesugi, Hisashi Matsubara (JAPAN)

17:30Comparison of constant luminance (cd•s/m2) versus constant retinal illuminance (Td-s) stimulation in the flicker ERG

Quentin Davis, Olga Kraszewska, Colette Manning (UNITED STATES)

17:45 The topography of spatial-frequency tuning of the steady-state pattern-onset VEP

Sven P. Heinrich, Lisa Herold, David J. Marhöfer, Michael Bach (GERMANY)

18:00iSim: a smart ERG signal generator for calibration of instruments and alignment of recording regimes across clinical laboratories

Anthony C. Fisher, Rasam Teymouri, Matthew Elt (UNITED KINGDOM)

18:15 Group photo

Friday, June 26, 2015Linhart hall

09:00 – 10:45 Paper session 5 – Toxicology and treatment – Oral

Moderators: Karen Holopigian, Mitchell Brigell

09:00 Contribution of the wide field imaging in the screening for Vigabatrin related retinopathy

Carl Arndt, Kim Vardi, Jacques Motte, Nathalie Bednarek, Joseph Bursztyn, Alain Ducasse, Catherine Brugniart (FRANCE)

09:15 Diagnostic methods in ocular argyrosis

Monika Sarnat-Kucharczyk, Ewa Mrukwa-Kominek, Dorota Pojda-Wilczek (POLAND)

09:30 Multifocal ERG in eyes subjected to inverted ILM flap technique for treating macular hole

Masayuki Horiguchi, Yoshiaki Shimada, Mitsuo Sugimoto, Atsuhiro Tanikawa (JAPAN)

09:45ERG findings after one year intravitreal ranibizumab and single or multiple spot panphotocoagulation treatment for proliferative diabetic retinopathy

Katharina Messias, Rafael De Montier Barroso, Fabiano Sakamoto, Vinicius Castro, Amanda Marega, Rodrigo Jorge, Andre Messias (BRAZIL)

10:00Functional outcome in prospective intravitreal bevacizumab treatment of macular edema secondary to central retinal vein occlusion

Ivana Gardašević Topčić, Maja Šuštar, Marko Hawlina, Polona Jaki Mekjavić (SLOVENIA)

10:15Neuroprotective effect of angiotensin receptor blockers and angiotensin converting enzyme inhibitors, used for high blood pressure, on the retina of diabetes mellitus type 2 patients studied by mfERG

Graciela Garcia Briones, Mario Alberto Rendon M, Bruno Estañol Vidal (MEXICO)

10:30 Multifocal ERG before and after pars plana vitrectomy in ILM peeling – one-year follow-up

Andre Messias, Ana Claudia De Lucca Perches, Felipe Almeida, Katharina Messias, Rodrigo Jorge (BRAZIL)


11:15 – 13:00 Paper session 6 – Retinal diseases – Oral

Moderators: Alma Patrizia Tormene, Vernon Odom

11:15 The clinical and electrophysiological features of unilateral pigmentary retinopathy

Anthony G. Robson, Marie-Helene Errera, Tracy Wong, Philip G. Hykin, Bishwanath Pal, Mandeep S. Sagoo, Carlos E. Pavesio, Anthony T. Moore, Andrew R. Webster, Graham E. Holder (UNITED KINGDOM)

11:30Electrodiagnostic testing facilitates the identification of two novel retinal dystrophy genes: a new paradigm for disease gene discovery

Panagiotis I. Sergouniotis, Anthony G. Robson, Uwe Wolfrum, Eva Lenassi, Ucl-Exomes Consortium , Martin Mckibbin, Manir Ali, Vincent Plagnol, Andrew R. Webster, Graham E. Holder (UNITED KINGDOM)

xvii

11:45 Japan whole exome project for inherited retinal diseases 2014

Kaoru Fujinami, Takaaki Hayashi, Kazuki Kuniyoshi, Mineo Kondo, Shinji Ueno, Kei Shinoda, Kazuo Tsubota, Yozo Miyake, Kazushige Tsunoda, Takeshi Iwata (JAPAN)

12:00 ERG in Slovenian patients with Usher syndrome

Ana Fakin, Martina Jarc-Vidmar, Branka Stirn Kranjc, Maja Šuštar, Jelka Brecelj, Marko Hawlina (SLOVENIA)

12:15 Interesting phenotype and electrophysiological findings in Slovene family with ABCA4 mutation

Martina Jarc-Vidmar, Ana Fakin, Maja Šuštar, Jelka Brecelj, Branka Stirn-Kranjc, Damjan Glavač, Marko Hawlina (SLOVENIA)

12:30 Inner retinal dysfunction at the macula in patients with ‘macula-on’ rhegmatogenous retinal detachment

Kunihiko Akiyama, Kaoru Fujinami, Ken Watanabe, Natsuko Nakamura, Toru Noda, Yozo Miyake, Kazushige Tsunoda (JAPAN)

12:45 Retinal dystrophy with supernormal and delayed rod ERG b-waves: a possible explanation

John Robson (UNITED STATES)

13:00 – 14:30 Lunch

14:30 – 16:00 Paper session 7 – Animal electrophysiology – Oral

Moderators: Pierre Lachapelle, Mathias W. Seeliger

14:30Introductory lecture: Oxidative retinopathies in neonatal rats: subtle onset with long-term devastating consequences

Pierre Lachapelle, Anna Polosa, Allison L. Dorfman, Samaneh Chaychi, Xiaojuan Yang (CANADA)

15:00 Bright light exposure in photoreceptor-only rodent model: unexpected findings

Anna Polosa, Suna Jung, Fares Antaki, Hyba Bessaklia, Pia Wintermark, Pierre Lachapelle (CANADA)

15:15 Silent substitution isolation of rod and cone function in mice transgenic for human L-opsin

Tina Tsai, Jenny Atorf, Maureen Neitz, Jay Neitz, Jan Kremers (GERMANY)

15:30 Sildenafil as a potential therapy for visual impairments associated with birth asphyxia: a rat study

Suna Jung, Zehra Khoja, Aaron Johnstone, Pierre Lachapelle, Pia Wintermark (CANADA)

15:45Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signaling in experimental autoimmune uveitis

Bo Lei, Hongxia Yang, Shijie Zheng, Yingying Mao, Hongwei Li, Zihe Chen (CHINA)


16:15 – 17:45 Membership meeting

19:00 – 20:00 Adachi award lecture

Metabolic disease with choroidal atrophy: gyrate atrophy and LCHADD

Richard Weleber (UNITED STATES) Introduction: Colin Barber (UNITED KINGDOM)

20:00 – 23:00 Conference dinner (Club CD)

xviii

Saturday, June 27, 2015Linhart hall

09:00 – 10:45 Paper session 8 – Retinal function and structure – Oral

Moderators: Mary Johnson, Audrey Chia Wei Lin

09:00 Evidence for an asymmetrical effect of type 1 diabetes on retinal structure and function

Thomas Wright, Alan Poon, Ahmed Salem, Carol Westall (CANADA)

09:15 Comparing the retinal structure, function and biochemistry in a animal model of spontaneous diabetes

Serge Rosolen, Sylvie Lavillegrand, Stephanie Lafarge-Beurlet, Pierre-Francois Isard, Charles Cassagnes, Thomas Dulaurent, Serge Picaud, Patricia Crissanti, Marianne Berdugo (FRANCE)

09:30Assessment of macular function and structure in patients with idiopathic epiretinal membrane treated by pars plana vitrectomy

Wojciech Lubiński, Wojciech Gosławski, Leszek Kuprjanowicz, Karol Krzystolik, Maciej Mularczyk (POLAND)

09:45 Unmasking ERG ON-OFF interactions with the discrete wavelet transform (DWT)

Mathieu Gauvin, Maja Šuštar, Jean-Marc Lina, John M. Little, Robert K. Koenekoop, Pierre Lachapelle (CANADA)

10:00 Does flicker ERG depend on stimulus color?

Olga Kraszewska, Quentin Davis, Colette Manning (UNITED STATES)

10:15 Correlation between macular cone density and focal macular electroretinogram in normal eyes

Hiroko Terasaki, Kennichi Kawano, Yasuki Ito, Taro Kominami, Shinji Ueno (JAPAN)

10:30 When function, structure and electrophysiology don’t agree

Michael Marmor (UNITED STATES)


11:15 – 12:00 Dodt and Marmor award

12:00 – 12:10 Closing ceremony

12:15 – 13:30 Lunch

15:00 – 21:00 ISCEV Olympics and picnic at lake Bled

xix

INFORMATION FOR SPEAKERS AND POSTER PRESENTERSPoster presentationsPosters will be displayed in Foyer II. Display boards will be numbered. Presenting authors are requested to be available for discussion next to their posters during the scheduled time. Posters will be displayed all the time during the congress. Cankarjev dom is not responsible for any poster left behind at the end of the day.

Speakers’ CentreThe technical organizer will give you additional instructions concerning your session and the presentation of your paper in the Speakers’ Centre. The Congress staff will ensure that your presentation is downloaded on the computer in your specific session room. Please make sure that your computer presentation is fully operational before your talk. Only Power Point presentations, CDROM, ZIP disk USB1 Memory cards will be accepted. Version MS PowerPoint 2007 is recommended. We recommend installing and testing your computer presentation at least two hours before your talk. A technician and a room attendant will be in every room to provide assistance when needed. The Speakers’ Centre will have the same opening hours as the registration desk.

InternetWireless internet connection is available in Foyer II. The name of the network is CDWLAN. No login or password is required.

REGISTRATION AND FEESParticipant’s registration fee includes:• Participation in all lectures

• Congress bag including programme and abstract book

• Electronic Abstract Book

• Certificate of Attendance

• Welcome Reception

• Coffee during breaks

• Lunches

• Conference Dinner

• Sports Game & Outdoor Party at Bled

The registration fee for Accompanying Person’s includes:• Welcome Reception / Wednesday, June 24

• Sightseeing of Ljubljana / Thursday, June 25, 10.00–12.00

• Excursion to Postojna and Predjama Castle - half day/ Friday, June 26, 9.00–14.30

• Conference Dinner / Friday, June 26, 20.00–24.00

• Sports Game & Outdoor Party at Bled / Saturday, June 27, 15.00–19.00

Registration and Information Desk The ISCEV 2015 Registration Desk is located in Foyer II of Cankarjev dom and is open as follows:

Wednesday, June 24 17.00–20.00

Thursday, June 25 8.00–19.00

Friday, June 26 8.00–19.00

Saturday, June 27 8.00–14.00

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SOCIAL PROGRAMMEWEDNESDAY, JUNE 24, 201520.00–23.00 Welcome Reception/Ljubljana Castle Included in the fee for participants and accompanying persons.

Meeting point: 19.45 at Cankarjev dom, Erjavčeva Street (by bus), returning at 23.00

Please note that you can take a funicular train to the Ljubljana Castle.

Price:

• Return ticket à EUR 4.00

• Single ticket à EUR 2.20

FRIDAY, JUNE 26, 201520.00–23.00 Conference Dinner/Cankarjev dom – CD Club Included in the fee for participants and accompanying persons.

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SATURDAY, JUNE 27, 201515.00–21.00 Sports game and Outdoor Party at Bled Included in the fee for participants and accompanying persons.

Meeting point: 14.45 at Cankarjev dom, Erjavčeva Street (by bus), returning at 21.00

GENERAL INFORMATIONConference Identification Badge A conference identification badge will be included in the conference material provided at registration. There will be no admittance to the Scientific Sessions without the conference badge. Invitations to social events will be collected at the entrance.

Attendance CertificateA Certificate of Attendance will be issued to all registered participants.

Coffee BreaksDuring breaks, refreshments will be served free of charge to participants wearing congress badges.

Lunches Working lunches (standing buffet) are included in the registration fee and will be served at lunchtime in Foyer II.

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ABSTRACTS……………

3

Scanning laser ophthalmoscope and modules:

ROLANDCONSULT

Electrophysiological diagnostic systems

M

VEP

Angiography

mfERG

OCT

GFP

RETImap animal®

Friedrich-Franz-Str.19, D-14770 Brandenburg/Germany, www.roland-consult.de

VEP

Angiography

mfERG

OCT

cSLO

VEP

Electrophysiology & Imaging for Retina Diagnostic

RETImap® Model 520

ROLANDCONSULT


2,5µV/div

25 ms/div

Ganzfeld ERG Stimulator MonitorMacula ModuleOperator unit

ON-OFF response

ac d

b

e

N

PhNR response

b

i

PhNRa

4

Light-adapted 3.0 ERG a-wave: cones with post-receptoral on & off pathways b-wave: on & off bipolar cells

Dark-adapted 3.0 ERG a-wave: photoreceptors & postreceptoral on pathways b-wave: on & off bipolar cells

Dark-adapted 3.0 oscillatory potentialsOn & off pathways reflecting middle retinal layers & vascular function

Dark-adapted 0.01 ERG b-wave: rod-initiated on pathways

Light-adapted 3.0 flickerCone systems with post-receptoral on & off pathways

Dark-adapted 10.0 ERGa-wave: photoreceptors & postreceptoral on pathways b-wave: predominantly rod bipo-lar cells (on pathways)

a

b

ba

t

t

ab

peak time (t)

t

ALL IN ONE


R

xxv3

Scanning laser ophthalmoscope and modules:

ROLANDCONSULT


M

VEP

Angiography

mfERG

OCT

GFP

RETImap animal®


AUTHOR’S INDEX

VEP

Angiography

mfERG

OCT

cSLO

VEP

Electrophysiology & Imaging for Retina Diagnostic

RETImap® Model 520

ROLANDCONSULT


2,5µV/div

25 ms/div

Ganzfeld ERG Stimulator MonitorMacula ModuleOperator unit

ON-OFF response

ac d

b

e

N

PhNR response

b

i

PhNRa

4

Light-adapted 3.0 ERG a-wave: cones with post-receptoral on & off pathways b-wave: on & off bipolar cells

Dark-adapted 3.0 ERG a-wave: photoreceptors & postreceptoral on pathways b-wave: on & off bipolar cells

Dark-adapted 3.0 oscillatory potentialsOn & off pathways reflecting middle retinal layers & vascular function

Dark-adapted 0.01 ERG b-wave: rod-initiated on pathways

Light-adapted 3.0 flickerCone systems with post-receptoral on & off pathways

Dark-adapted 10.0 ERGa-wave: photoreceptors & postreceptoral on pathways b-wave: predominantly rod bipo-lar cells (on pathways)

a

b

ba

t

t

ab

peak time (t)

t

ALL IN ONE


R

xxvi

OGLASI RETIcompact II®

ALL IN ONE

mfERG

VEP

ERG

EOG

Visual Acuity

Glaucoma Screening

Pupillometry

mfERG 3D-plot

Pattern Handheld BABYflashMINIganzfeld

ISCEV Standard: Diagnostic for Macula, Retina and Diabetic

Your Objective Diagnostic T

ool!

Electrophysiological Diagnostic for Macula, Retina and Diabetic

Special tools for children:

ROLANDCONSULT

Electrophysiological diagnostic systemsFriedrich-Franz-Str.19, D-14770 Brandenburg/Germany, www.roland-consult.de

C D

Normal patient

Patients view

ROLAND DARKadaptometer and Pupillometer

ROLANDCONSULT


Pupillometry measurement

Specifications:

. Maximum bleaching luminance between 6500 - 7000 cd/m². Stimulus spot colors: red (625nm) and green (527nm). Maximum spot brightness 250 cd/m². Minimum spot brightness 2.5 * 10-8 cd/m². Fixation target brightness: 50. Stimulus impulse with a PWM of 225Hz. Stimulus spot size: 2°. Fixations: Center (5°), 10°, 20°(default), 30°, 40°

Metabolic disorders . Vitamin A-Def ciency . Exposu

re to

retin

otox

ic a

gent

s

Hereditary retinopathies . Immune & Inf ammatory eye diseases


xxvii

RETIcompact II®

ALL IN ONE

mfERG

VEP

ERG

EOG

Visual Acuity

Glaucoma Screening

Pupillometry

mfERG 3D-plot

Pattern Handheld BABYflashMINIganzfeld

ISCEV Standard: Diagnostic for Macula, Retina and Diabetic

Your Objective Diagnostic T

ool!

Electrophysiological Diagnostic for Macula, Retina and Diabetic

Special tools for children:

ROLANDCONSULT

Electrophysiological diagnostic systemsFriedrich-Franz-Str.19, D-14770 Brandenburg/Germany, www.roland-consult.de

C D

Normal patient

Patients view

ROLAND DARKadaptometer and Pupillometer

ROLANDCONSULT


Pupillometry measurement

Specifications:

. Maximum bleaching luminance between 6500 - 7000 cd/m². Stimulus spot colors: red (625nm) and green (527nm). Maximum spot brightness 250 cd/m². Minimum spot brightness 2.5 * 10-8 cd/m². Fixation target brightness: 50. Stimulus impulse with a PWM of 225Hz. Stimulus spot size: 2°. Fixations: Center (5°), 10°, 20°(default), 30°, 40°

Metabolic disorders . Vitamin A-Def ciency . Exposu

re to

retin

otox

ic a

gent

s

Hereditary retinopathies . Immune & Inf ammatory eye diseases


xxviii

leading the wave

Introducing the ColorLens: a compact, high-throughput ERG solution for mice

Welcome to ISCEV!

• Reproducible results• Runs various phenotyping protocols• Simple to use

Come see our full suite ofelectrophysiology systems

• ERG• EOG• PERG• Flash VEP• Pattern VEP• Multifocal/Focal• Dark Adaptometry• Pupillometry

xxix

leading the wave

Introducing the ColorLens: a compact, high-throughput ERG solution for mice

Welcome to ISCEV!

• Reproducible results• Runs various phenotyping protocols• Simple to use

Come see our full suite ofelectrophysiology systems

• ERG• EOG• PERG• Flash VEP• Pattern VEP• Multifocal/Focal• Dark Adaptometry• Pupillometry

xxx

RETeval TM

Visual Electrodiagnostic System – like having your current flash based system in the palm of your hand

Easy to Use

• Instant results displayed on screen

• Built-in pupillometry adjusts flash and background intensity, enabling testing without pupil dilation

• Single electrode array is placed on skin for each eye (Patent Pending)

• IR camera allows visualization of eye during test

• Simple joystick control

• Multi-lingual user interface

• Fixation LED for the patient

• Blink and electrode-disconnected detection for more reliable results

• Built-in photometer ensures correct brightness and color of stimulation

• EMR interface available

• Reports viewable on the device or on a PC using the USB interface in the base unit

Available in two separately priced configurations:

DR/CSME Assessment using skin Electrodes: The Welch Allyn® RETeval – DRTM , manufactured by LKC Technologies for Welch Allyn®, is available exclusively through Welch Allyn® outside of the United States.

ORRETeval complete option: In addition to the flicker and DR testing, the complete option enable ISCEV-compliant 5 and 6 step protocols, flash VEP, photopic negative response, s-cone, and much more! Use the LKC Sensor Strip skin electrode [95-068] or, with an optional adapting cable, you can use any electrode type.

This project described was supported by Award Number R44EY021121 from the National Eye Institute. The content is solely the responsibility of LKC and does not necessarily represent the official views of the National Eye Institute of the National Institutes of Health.

The device is CE Marked and licensed for sale in Canada, Australia, Japan, Israel and Saudi Arabia. In the United States, it is currently available for research investigational use only under IRB approval and control.

The device may be covered by one or more of the following US patents and their foreign counterparts: 7,540,613. Additional patents are pending. RETeval™ and RETeval – DR™ are registered trademarks of LKC Technologies, Inc. Welch Allyn is a registered trademark of Welch Allyn, Inc. RETeval™ is a registered trademark in the following countries: Canada, China, Japan, Mexico, Russian Federation, South Korea, Brazil, the E.U. and the United States of America.

• Fully ISCEV compliant – Flash ERG – Flash VEP

• Non-mydriatic ‒ patented dynamically controlled flash intensities utilizing pupilography• Non-invasive skin electrodes or traditional corneal electrodes ‒ your choice• Fixed flash intensities or troland base flash intensities per the ISCEV protocol for dilated eyes - your choice• Hand-held ‒ easy to use ‒ easy to learn ‒ comprehensive reporting ‒ outstanding performance• Easy to create custom protocols• Innovative file structure retains all raw data on each test for easy and comprehensive analysis ‒ researcher’s dream• A clinically validated diabetic retinopathy (DR) and clinically significant macular edema (CSME) protocol is available in the RETeval Complete system from LKC, or in standalone form exclusively through Welch Allyn® as Welch Allyn® RETeval - DRTM.

www.lkc.com COSTRUZIONE STRUMENTI OFTALMICI

RETIMAX BASIC, ADVANCED E ADVANCED PLUS

Glaucoma PERG Hemifield TestDiagnosi precoce del Glaucoma.Database normativo correlato all’età per itest ERG, PERG, VEP, EOG.Vision Trainer Riabilitazione visivaBiofeedback

RETIMAX ADVANCED & ADVANCED PLUSConform to ISCEV standard (International Society for Clinical Electrophysiology of Vision) Compact and user friendly RETIMAX. Useful for the functional assessment of retina, ganglion cells and Optic Nerve. RETIMAX plus COBRA fundus camera adds new attractive feature at the Multifocal ERG, PERG and VEP, the combination Between Multifocal ERG and photographic image of the Retina.

Via degli Stagnacci 12/E50018 Scandicci, Firenze (Italy)Tel. ++39 055.722191 – www.csoitalia.it

RETeval TM

Visual Electrodiagnostic System – like having your current flash based system in the palm of your hand

Easy to Use

• Instant results displayed on screen

• Built-in pupillometry adjusts flash and background intensity, enabling testing without pupil dilation

• Single electrode array is placed on skin for each eye (Patent Pending)

• IR camera allows visualization of eye during test

• Simple joystick control

• Multi-lingual user interface

• Fixation LED for the patient

• Blink and electrode-disconnected detection for more reliable results

• Built-in photometer ensures correct brightness and color of stimulation

• EMR interface available

• Reports viewable on the device or on a PC using the USB interface in the base unit

Available in two separately priced configurations:

DR/CSME Assessment using skin Electrodes: The Welch Allyn® RETeval – DRTM , manufactured by LKC Technologies for Welch Allyn®, is available exclusively through Welch Allyn® outside of the United States.

ORRETeval complete option: In addition to the flicker and DR testing, the complete option enable ISCEV-compliant 5 and 6 step protocols, flash VEP, photopic negative response, s-cone, and much more! Use the LKC Sensor Strip skin electrode [95-068] or, with an optional adapting cable, you can use any electrode type.

This project described was supported by Award Number R44EY021121 from the National Eye Institute. The content is solely the responsibility of LKC and does not necessarily represent the official views of the National Eye Institute of the National Institutes of Health.

The device is CE Marked and licensed for sale in Canada, Australia, Japan, Israel and Saudi Arabia. In the United States, it is currently available for research investigational use only under IRB approval and control.

The device may be covered by one or more of the following US patents and their foreign counterparts: 7,540,613. Additional patents are pending. RETeval™ and RETeval – DR™ are registered trademarks of LKC Technologies, Inc. Welch Allyn is a registered trademark of Welch Allyn, Inc. RETeval™ is a registered trademark in the following countries: Canada, China, Japan, Mexico, Russian Federation, South Korea, Brazil, the E.U. and the United States of America.

• Fully ISCEV compliant – Flash ERG – Flash VEP

• Non-mydriatic ‒ patented dynamically controlled flash intensities utilizing pupilography• Non-invasive skin electrodes or traditional corneal electrodes ‒ your choice• Fixed flash intensities or troland base flash intensities per the ISCEV protocol for dilated eyes - your choice• Hand-held ‒ easy to use ‒ easy to learn ‒ comprehensive reporting ‒ outstanding performance• Easy to create custom protocols• Innovative file structure retains all raw data on each test for easy and comprehensive analysis ‒ researcher’s dream• A clinically validated diabetic retinopathy (DR) and clinically significant macular edema (CSME) protocol is available in the RETeval Complete system from LKC, or in standalone form exclusively through Welch Allyn® as Welch Allyn® RETeval - DRTM.

www.lkc.com COSTRUZIONE STRUMENTI OFTALMICI

RETIMAX BASIC, ADVANCED E ADVANCED PLUS

Glaucoma PERG Hemifield TestDiagnosi precoce del Glaucoma.Database normativo correlato all’età per itest ERG, PERG, VEP, EOG.Vision Trainer Riabilitazione visivaBiofeedback

RETIMAX ADVANCED & ADVANCED PLUSConform to ISCEV standard (International Society for Clinical Electrophysiology of Vision) Compact and user friendly RETIMAX. Useful for the functional assessment of retina, ganglion cells and Optic Nerve. RETIMAX plus COBRA fundus camera adds new attractive feature at the Multifocal ERG, PERG and VEP, the combination Between Multifocal ERG and photographic image of the Retina.

Via degli Stagnacci 12/E50018 Scandicci, Firenze (Italy)Tel. ++39 055.722191 – www.csoitalia.it

xxxii

ELECTROPHYSIOLOGY EP-1000

LED colour fl ash and background illumination Programme editor for individual examinations Multifocal ERG ISCEV conform standard tests S-Cone analysis, PERG Ratio

Standardised, compact and multifunctional.

Normal data overlay

Measurement display

EP-1000 Multifocal

VEP Children ext.PERG Ratio

TOMEY GmbH | Am Weichselgarten 19a | 91058 Erlangen, Germany | Phone +49 9131 777 10Fax +49 9131 777 1 20 | Email [email protected] | www.tomey.de

TOM_Anzeige_A4_EP1000.indd 1 21.05.15 16:38

xxxiii

ELECTROPHYSIOLOGY EP-1000

LED colour fl ash and background illumination Programme editor for individual examinations Multifocal ERG ISCEV conform standard tests S-Cone analysis, PERG Ratio

Standardised, compact and multifunctional.

Normal data overlay

Measurement display

EP-1000 Multifocal

VEP Children ext.PERG Ratio

TOMEY GmbH | Am Weichselgarten 19a | 91058 Erlangen, Germany | Phone +49 9131 777 10Fax +49 9131 777 1 20 | Email [email protected] | www.tomey.de

TOM_Anzeige_A4_EP1000.indd 1 21.05.15 16:38

EXHIBITION PLAN

NOTES

NOTES

Documents

53 Symposium of International Society for Clinical ... · PDF fileOrganised by: International Society for Clinical Electrophysiology of Vision – ISCEV Slovenian Society of Ophthalmology