2013.11.2 1
10DLB
DLB
QOL
DLB
DLB
7
DLB
P r e f a c e
2 7
9:30~11:45
11:00~11:45
12:00~12:15
12:20~13:10
DAT
13:15~
13:20~13:50 1
P r o g r a m
2013.11.2 3
13:55~14:25 2
14:30~15:00 3
15:00~15:15
15:15~15:45 4
15:50~16:20 5
16:20~16:40
16:40~17:00MIBG
17:00
L u n c h e o n S e m i n a r
6 7
DAT SPECT/PET
DLB 3
1DAT SPECT
DATDLB
AD
AD dementiaMCI
due to ADDLBADDLB 2
DAT 123I-MIBG
DAT
L u n c h e o n S e m i n a r
S y m p o s i u m
8 7
PD 55 70
4 10 150
18 L-
ParkinsonPD
80%
DLBLevy
PD
PDDDLB PDD
Levy
DLB
PDDLB
1S u b j e c t 1
2013.11.2 9
DLB
DLB 23
DLB
DLBAD
DLB
late
paraphreniaLP
LPRoth
LP
DLBADLP
2
2S u b j e c t 2
10 7
DLBPD
DLB
Horimoto 29DLB97%83%
66%28%
85%
DLB
32%
Sakakibara 91% 100ml 27%
1528%
PD
OH 50%
MIBGMIBG
ADDLB152
3S u b j e c t 3
2013.11.2 11
194/ 98%/94%
SSwR PD
SkVR PDDLB
CASSDLB
PDMizukamiDLB
AD
12 7
RBD
1996 Schenck 1
RBD 1038%PD
2003 Boeve 2 15RBD
15 10 2 29RBD
15 12
RBD-Boeve 3
RBD170PD32DLB97
MSA19 77
59MSA1916094%-
RBD
Braak PD 1 /
23
RBD 2
Iranzo 4 44RBD3682%
PD16DLB14MSA1
RBD 5 34.8%10 73.4%14 92.5%
RBD PDDLBMSA
PET SPECTDAT
4S u b j e c t 4
2013.11.2 13
PD3DAT
RBD 5
RBD SPECTPET
MRIRBD PDDLBMSA
RBD [123I]MIBG /H/M
Kashihara 6RBD13PD222 50 [123I]
MIBGRBDH/MHoehn & Yahr 1 2
PDHoehn & Yahr3 4 PDRBD PD
RBDPD
PD RBDPD 3060%RBD
DLB 70%RBDMSA 90100%RBD
-RBD
Garcia-Lorenzo 7RBD PD24RBD
PD12 193TMRI
/subcoeruleusRBD PD /subcoeruleus
RBD PD /subcoeruleus
PD /
subcoeruleusRBD
RBD PDDLB-
RBD
10
SPECT
PD DLBMSA
1Schenck CH, et al. Neurology 1996; 46: 388-393.2Boeve BF, et
al. Neurology 2003; 61: 40-45.
3Boeve BF, et al. Sleep Med 2013; 14: 754-762.4Iranzo A, et al.
Lancet Neurol 2013; 12: 443-
453.5Iranzo A, et al. Lancet Neurol 2011; 10: 797-805.6Kashihara
K, et al. Parkinsonism
Relat Disord 2010; 16: 252-255.7Gardica-Lorenzo D, et al. Brain
2013; 136: 2120-2129.
14 7
DLB
DLB
14DLB
DLB
DLB
AD
DLB
DLB
DLB
DLB
DLB
SPECTMIBGSPECT
MIBGDLBDLB
DLB
DLB
5S u b j e c t 5
2013.11.2 15
DLBSSRISNRI
ECTTMS
16 7
MIBG
S u b j e c t
18 7
WatanabeYoshitaMIBGMIBGDLBAlzheimerAD
YoshitaMIBG
-H/M cut o! point 1.68parkinsonism
100%DLBAD
evidenceConsortium on dementia with Lewy bodiesCDLB
supportive featureMIBG
4
behavioral and psychological symptoms of dementia;
BPSDBPSD
H/M 1.68MIBG
MIBG LBDPDD
DLB
S u b j e c t
2013.11.2 19
2013 2 1 2013 7 31MIBG 40
Alzheimer 21 LBDPDDDLB19 2
2 t
ADH/M 2.69LBD 1.58
H/M 2.77 1.3295% cut o! point
2.4 86% 94%
MIBGH/MAD LBDPDDDLB
MIBG
20 7
2013.11.2 21
/ PCU
/ PCU
CNS
MeijiSeika
RI
22 7
RI
2013.11.2 23
