65 SRI AM/am18... · MARCH 6 - 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 1 MESSAGE FROM THE SRI PRESIDENT Dear Colleagues: Welcome to the 65th Annual Scientific Meeting of

MARCH 6 - 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 1

Society for Reproductive Investigation

POWER OF COLLABORATION

65th Annual Scientific MeetingMarch 6 - 10, 2018

Hilton San Diego Bayfront, 1 Park BoulevardSan Diego, CA 92101

SRI65 Years of Advancing

Reproductive andWomen's Health Care

65Years

FINAL PROGRAMContinuing Medical Education credit is provided through joint providership with

The American College of Obstetricians and Gynecologists

SRI-0118-604

2 SOCIETY FOR REPRODUCTIVE INVESTIGATION 65th Annual Scientific Meeting

TABLE OF CONTENTS

SRI65 Years of Advancing

Reproductive andWomen's Health Care

65Years

Message from the SRI President . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 12018 Program Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2General Meeting Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3Schedule-at-a-Glance . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4Social Events and Location Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5Exhibitors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6Hilton San Diego Bayfront Map . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7Continuing Medical Education Information . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8Scientific Program . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9Poster Guide . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 59Thank You to Our 2018 Poster Judges . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 98SRI Grants Progam . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1002018 Awards . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 101About SRI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 104SRI Council & Staff . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 105Oral and Poster Abstract Author Index . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 106Notes . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 127Thank You to Our 2018 Supporters . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 129Save the Date: SRI 2019 Annual Meeting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . Back Cover

SRI 65th Annual Scientific Meeting VenueHilton San Diego Bayfront 1 Park Boulevard San Diego, CA 92101 Phone: +1-619-564-3333

Future SRI Annual Scientific Meetings SRI 66th Annual Scientific Meeting • Paris, France • March 12-16, 2019 SRI 67th Annual Scientific Meeting • Vancouver, Canada • March 10 – 14, 2020 SRI 68th Annual Scientific Meeting • Boston, MA • March 23 – 27, 2021

Society for Reproductive Investigation 555 East Wells Street, Suite 1100

Milwaukee, WI 53202-3823 Phone: +1-414-918-9888

Fax: +1-414-276-3349 Email: info@sri-online .org

Website: www .sri-online .org© Society for Reproductive Investigation . All Rights Reserved .


MESSAGE FROM THE SRI PRESIDENT Dear Colleagues:

Welcome to the 65th Annual Scientific Meeting of the Society for Reproductive Investigation (SRI), March 6-10, 2018 in San Diego, CA . The theme of the 2018 meeting, “Power of Collaboration” was chosen to highlight the importance of collaborations and networking on the global stage . As a meeting theme for SRI, our goal is to further promote and highlight collaborations within the society as one of the many valuable aspects of SRI .

With Marilyn J . Cipolla, PhD as Program Director, we have developed an outstanding program that includes two Presidential Distinguished Lecturers, as well as a new half-day dedicated to the Career Development Workshops designed to allow our in-training attendees the opportunity to develop skills to help advance their career . We also continue to have the President’s New Investigator plenary session supported by The SRI’s Past President’s Fund, 24 concurrent oral sessions, and 12 mini-symposia .

Our first Presidential Distinguished Lecturer, Randy Schekman, PhD, Professor of Molecular and Cell Biology, UC Berkeley will be speaking on Thursday, March 8th at 8:00 am with his talk entitled “How Cells Export Proteins” . Dr . Schekman is the 2013 Nobel Prize winner in Physiology or Medicine for the discovery of the genes and proteins that govern cell membrane trafficking, which has been his focus of research for the past thirty years . His work on cellular trafficking has proven vital to our understanding of why specific diseases occur .

Our second Presidential Distinguished Lecturer is Ursula Kaiser, MD Professor, Harvard Medical School, Chief, Division of Endocrinology, Diabetes and Hypertension, will be speaking Friday, March 9th at 8:00 am . Her talk is entitled, “Genetic and Molecular Pathways Controlling Puberty: The Importance of Collaboration in Translational Research” . Dr . Kaiser’s research is focused on genetic and molecular mechanisms underlying the neuroendocrine regulation of reproductive development and function .

New this year will be a special lunch-time panel focused on effective collaborations and networking . We also have two “Lunch and Learn” symposia that will be compelling and informative . Connection Corners, which has been a huge success and grown each year, will include our Distinguished Speakers, Drs . Randy Schekman and Urusla Kaiser .

On Friday, there will be a 65th Anniversary Salute, Presidential Address, and President’s Awards Ceremony . Beer, wine and appetizers will be provided during the addresses . For those of you who have purchased a ticket for the 65th Anniversary Party, this will then be followed by an evening celebrating 65 years of excellence, and enjoying dancing and music from our newly formed SRI Band .

To end our Program on Saturday, the Hot Pizza and Hot Topics will highlight the top four late breaking abstracts with oral presentations and awards for the top Poster Presentations .

True to our nature, the 65th Annual SRI meeting will be highly collegial and provide a forum for outstanding science and the opportunity for fruitful global networking . On behalf of the SRI Council, Program Committee, and Staff, thank you for attending the exciting meeting we have planned, and most importantly, celebrating with us 65 years of science in the service of women’s health!

Yours,

Sandra T . Davidge, PhD SRI President, 2017-2018


2018 PROGRAM COMMITTEE

Program Committee ChairEmre Seli, MD

Yale School of Medicine

2018 Program DirectorMarilyn J. Cipolla, PhD

University of Vermont

Elizabeth Ann Bonney, MD, MPHUniversity of Vermont

Sandra T. Davidge, PhDUniversity of Alberta

Charles Ducsay, PhDLoma Linda University

Sarah England, PhDWashington University School of Medicine

Stephen Matthews, PhDUniversity of Toronto

Sam Mesiano, PhDCase Western Reserve University

Leslie Myatt, PhD, FRCOGOregon Health and Science University

In Training RepresentativeFloor Spaans, PhDUniversity of Alberta


GENERAL MEETING INFORMATIONMeeting DescriptionThe SRI Annual Meeting gathers leading scientists and clinical investigators annually to share cutting-edge information in reproductive sciences and women’s health . The 65th Annual Meeting will feature an exciting lineup of distinguished lecturers, 12 mini-symposia sessions, several New Investigator events, career development sessions, and excellent scientific oral and poster presentations .

Meeting Location & Host Hotel Hilton San Diego Bayfront1 Park BoulevardSan Diego, CA 92101

Meeting Objectives• Provide attendees with state-of-the-art knowledge in the reproductive sciences and women’s

health research fields .• Gain insight into future directions from critical analysis of investigative findings .• Distinguished lectures and symposia will provide a focused format that fosters more meaningful

dialogue among clinicians and researchers .• Connect and network with international leaders who are advancing the scientific study of

reproductive and women’s health .

Target AudienceScientists and clinical investigators who conduct basic, translational and clinical investigation in reproductive sciences and women’s health .

Photography DisclaimerBy registering for the SRI Annual Meeting, you give consent to be photographed by SRI staff for purposes of advertising and public display .

Session Recording and PhotosSession content is copyright-protected by SRI . Recording of any session without the consent of SRI is prohibited . Any recording done with consent of SRI is for personal use only and cannot be reproduced or distributed . Please refrain from taking photos of the presenter or the presentations as it is disruptive and the flash is distracting .

No Smoking PolicySmoking is not permitted during any SRI activity or event .

WebsiteFor more information on the Society for Reproductive Investigation, visit our website at www .sri-online .org .


2018 SCHEDULE-AT-A-GLANCE

Tuesday March 6

Wednesday March 7

Thursday March 8

Friday March 9

Saturday March 10

Mor

ning

11:00 a.m. - 6:00 p.m.Registration

7:00 a.m. – 7:00 p.m. Registration

7:00 a.m. – 8:15 a.m. Mid-Career Investigator Breakfast

8:30 a.m. - 12:00 p.m.Satellite Sessions


8:00 a.m. – 10:00 a.m.President’s Welcome Address, President’s Distinguished Lecture I - Dr . Randy Schekman, New Investigator Plenary - supported by the Past President’s Fund

10:00 a.m. – 12:00 p.m.Poster Session I


8:00 a.m. – 9:00 a.m. President’s Distinguished Lecture II - Dr . Ursula Kasier

9:00 a.m. – 11:00 a.m. Poster Session II

11:00 a.m. – 12:30 p.m.Concurrent Oral Presentations II


8:00 a.m. – 9:00 a.m. SRI Business Meeting with breakfast, All SRI members invited

9:00 a.m. – 9:30 a.m. SRI Grant Program Recipient Presentations

9:30 a.m. – 11:30 a.m. Poster Session III

11:30 a.m. – 1:00 p.m. Concurrent Oral Presentations IV

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2:00 p.m. – 6:00 p.m. Bayer Sponsored Career Development Workshops

2:00 p.m. – 6:00 p.m. SRI Council Meeting

12:00 p.m. – 1:00 p.m. Diversity and Inclusion Forum *Lunch will be served

12:00 p.m. - 5:00 p.m.Satellite Sessions Continued

12:00 p.m. – 1:30 p.m. Special Lunch Symposium I

12:00 p.m. – 1:30 p.m. SRI Past President’s Lunch (Invitation Only)

1:30 p.m. – 3:30 p.m. Concurrent Oral Presentations I

3:30 p.m. – 4:00 p.m. Coffee Break

4:00 p.m. – 6:00 p.m. Mini Symposia I

12:30 p.m. – 2:00 p.m. Pfizer-SRI President’s Presenter’s Awards Lunch (By Invite Only)

12:30 p. m. – 2:00 p. m. Parallel Lunch and Learns

2:00 p. m. – 4:00 p.m. Mini Symposia II

4:00 p.m. – 4:30 p.m. Coffee Break

4:30 p. m. – 6:00 p.m. Concurrent Oral Presentations III

1:00 p.m. – 3:00 p.m. Hot Pizza and Hot Topics, Awards Lunch

3:15 p.m. – 4:45 p.m. SRI Council Meeting

Even

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6:15 p.m. – 7:15 p.m. Mentor in a Cloud Networking Event

6:30 p.m. – 8:00 p.m. Welcome Reception

6:15 p. m. – 7:45 p.m. Connection Corners

6:00 p.m. – 7:30 p.m. 65th Annual President’s Address, Awards, with Wine, Beer and Cheese

8:00 p.m. – 11:00 p.m.65th Anniversary Party


SOCIAL EVENTS AND LOCATION INFORMATIONWelcome ReceptionWednesday, March 7, 2018 – 6:30 p.m. - 8:00 p.m.SAPPHIRE WEST FOYER/SAPPHIRE WEST TERRACE Join us for socializing, drinks and light appetizers.

New in 2018 - SRI Member LoungeOpen throughout the Annual Meeting on Wednesday, March 7 at 8:00 a.m. – Friday, March 9, 2018 at 6:00 p.m. SAPPHIRE 411 ABAll SRI Members are invited to the Member Lounge at the 65th Scientific Annual Meeting. The Member Lounge will be an area for you to meet with your colleagues, mentors, and mentees and to network with other SRI Members throughout the meeting.

Connection CornersThursday, March 8, 2018 – 6:15 p.m. - 7:45 p.m.SAPPHIRE WEST TERRACE New and Mid-Career Investigators are invited to come meet and connect with Senior Investigators about jobs, career advice or just some friendly banter. Drinks and light appetizers provided.

65th Anniversary PartyFriday, March 9, 2018 – 8:00 p.m. - 11:00 p.m. JOES CRAB SHACK – THE ROWING CLUB A ticketed event hosted at Joe’s Crab Shack featuring a performance by the new SRI Band – The Featles.

About San DiegoMarch Weather: Average High: 66°F, 19°C; Average Low: 54°F, 12°CLocal time: Pacific Standard TimePopulation: 1 .407million (2016)


EXHIBITORSLook for our Exhibitors in the Sapphire North Foyer near Registration .

Femasys3950 Johns Creek Court, Suite 100Suwanee, GA 30024Phone: +1-770-500-3910Email: dtoledo@femasys .comwww .femasys .com

ObsEva, IncOne Financial CenterBoston, MA 02111Phone: +1-347-267-5406Email: loredana .cuccia@obseva .comwww .obseva .com

Reproductive Scientist Development Program (RSDP)Washington University School of Medicine425 South Euclid AvenueCampus Box 8064, BJC-IH, 10th FloorSt . Louis, MO 63110Phone: +1-314-747-0264Email: heflina@wustl .eduwww .rsdp .wustl .edu

Society of Family Planning & Research Fund255 South 17th Street, Suite 2709Philadelphia, PA 19103Phone: +1-866-584-6758Email: ssot@societyfp .orgwww .societyfp .org

UBS Financial Services Inc.131 Sount Rodeo Dr ., Suite 300Beverly Hills, CA 90212Phone: +1-310-281-4646Email: rrobert .levin@ubs .comwww .ubs .com/fa/robertlvein

mailto:[email protected]

http://www.femasys.com


http://www.obseva.com


http://www.rsdp.wustl.edu


http://www.societyfp.org/


http://www.ubs.com/fa/robertlvein


HILTON SAN DIEGO BAYFRONT MAP


CONTINUING MEDICAL EDUCATION INFORMATION

PurposeProvide an opportunity for physicians to receive updated information and solidify their knowledge of reproductive sciences and women’s health .

Target AudiencePhysicians and scientists who are involved in the evaluation and/or care of patients requiring reproductive health care . Participants should be clinicians or scientists who have backgrounds in the fields of obstetrics, perinatology, reproductive genetics, gynecology and gynecologic oncology, endocrinology, reproductive physiology, biochemistry, pharmacology, immunology, epidemiology, reproductive infectious disease, reproductive stem cell and developmental biology .

Learning ObjectivesAt the completion of the activity participants should be able to:• Describe key research findings related to reproductive sciences and women’s health .• Recognize the translational value of new research to women’s health and personalized medicine .• Understand the underlying pathophysiology of key areas of reproductive sciences and women’s

health .

ACCME Accreditation This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of The American College of Obstetricians and Gynecologists and Society for Reproductive Investigation . The American College of Obstetricians and Gynecologists is accredited by the ACCME to provide continuing medical education for physicians .

AMA PRA Category 1 Credit(s)TM

The American College of Obstetricians and Gynecologists designates this live activity for a maximum of 7 AMA PRA Category 1 CreditsTM . Physicians should claim only the credit commensurate with the extent of their participation in the activity .

College Cognate Credit(s)The American College of Obstetricians and Gynecologists designates this live activity for a maximum of 7 Category 1 College Cognate Credits . The College has a reciprocity agreement with the AMA that allows AMA PRA Category 1 CreditsTM to be equivalent to College Cognate Credits .

March 6 – 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 9

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SCIENTIFIC PROGRAM Tuesday, March 611:00 a.m. – 6:00 p.m. Registration

SAPPHIRE WEST FOYER2:00 p.m. – 6:00 p.m. Bayer Sponsored Career Development Workshops

AQUA CD*The Career Development Workshops are Non-CME Events2:00 p.m. – 3:00 p.m. Effective Presentation

Mary E. Wlodek, PhD University of Melbourne

3:00 p.m. – 4:00 p.m. Grant Writing 101: From idea to Specific AimsThomas Jansson, MD, PhDUniversity of Colorado

4:00 p.m. – 5:00 p.m. Ethics in ScienceDavid Resnik, JD, PhDNational Institutes of Health (NIH)

5:00 p.m. – 6:00 p.m. New Investigator Forum: Rules of CollaborationKristina Adams Waldorf, MDUniversity of WashingtonChris HaskellBayerRoberto Romero, MD, D.Med.Sci. National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH) Steven Yellon, PhDLoma Linda University

6:15 p.m. – 7:15 p.m. Mentor in a Cloud Speed Dating and Networking EventAQUA AB *for those who are part of the Mentorship Program *Wine and cheese will be served during this event


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SCIENTIFIC PROGRAM

Wednesday, March 77:00 a.m. – 7:00 p.m. Registration

SAPPHIRE WEST FOYER7:00 a.m. – 8:15 a.m.(Breakfast Served at 7:00 a .m .) Mid Career Investigator Breakfast

SAPPHIRE 400 ABFeaturing the following speakers and countries:China: Nanbert Zhong, MD, PhD and Gang Sun, MD, PhDMexico: Elena Zambrano, PhD and Peter Nathanielsz, MD, PhD, ScDTurkey: Emre Seli, MDEgypt: Mohamed Ali, BPharm, MSc and Huda Elkafas, MSc Brazil: Jim Roberts, MD, Tania Ortiga, PhD and Marcos Augusto Dias, PhD India: Ramkumar Menon, PhD, Mala Mahendroo, PhD

8:30 a.m. – 5:00 p.m. Endometrium Satellite Meeting Exploring Adenomyosis

AQUA 300 ABOrganizers: Peter A.W. Rogers, PhD University of Melbourne Asgi T. Fazleabas, PhD Michigan State University

Session 1: 8:30 a.m. – 12:00 p.m.8:30 a.m. – 9:30 a.m. What is Adenomyosis? Elizabeth A. (Ebbie) Stewart, MD Mayo Clinic College of Medicine9:30 a.m. – 10:00 a.m. Break10:00 a.m. – 10:30 a.m. Do N-Cadherin+ Endometrial Epithelial

Progenitor Cells Have a Role in Endometriosis and Adenomyosis?Caroline Gargett, PhDMonash University

10:30 a.m. – 11:00 a.m. EH16 4tjeffect of Administration of Selective Progesterone Receptor Modulators (SPRMs) on Uterine and Endometrial MorphologyLucy Whitaker, MBChB MD University of EdinburghThe Queen’s Medical Research Institute


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SCIENTIFIC PROGRAM Wednesday, March 7, continued

11:00 a.m. – 12:00 p.m. Adenomyotic Lesions as Wounds Undergoing Repeated Tissue Injury and Repair: Evidence and Clinical ImplicationsSun-Wei Guo, M.Med, PhDOB/GYN Hospital, Fudan University

12:00 p.m. – 1:30 p.m. LunchSession 2: 1:30 p.m. – 5:00 p.m.

1:30 p.m. – 2:30 p.m. Extracellular Vesicles (EVs) as Messengers in Embryo-Maternal Cross TalkFelipe Vilella, PhDValencia University

2:30 p.m. – 3:00 p.m. STAT3: A Key Transcriptional Factor Not Only in Embryo Implantation but also in Endometrial RegenerationYasushi Hirota, MD, PhDThe University of Tokyo

3:00 p.m. – 3:30 p.m. Novel Therapeutic Targets for EndometriosisChristian Becker, MDUniversity of Oxford

3:30 p.m. – 4:00 p.m. Break4:00 p.m. – 5:00 p.m. Forkhead Box A2 (FOXA2) and

Endometrial Glands Regulate Uterine Functions for Pregnancy EstablishmentThomas Spencer, PhDUniversity of Missouri

8:30 a.m. – 5:00 p.m. Fetal Physiology Satellite MeetingAQUA ABOrganizer: Charles Wood, PhD University of Florida8:30 a.m. – 9:30 AM The Placenta as Maternal-Fetal Conduit

and the Role of MicrobiotaKjersti Aagaard, MD, PhDBaylor University

9:30 a.m. – 10:00 a.m. Break


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10:00 a.m. – 11:00 a.m. Navigating the placental fortress with microbial friends and foes: Impact on fetal health and diseaseIndira U. Mysorekar, PhDWashington University

11:00 a.m. – 11:30 a.m. Physiological Exposure of the Fetus to BacteriaCharles Wood, PhD University of Florida

11:30 a .m . - 12:00 p .m . Intrauterine Placenta-Brain Lipid TransferTeresa Powell, PhD University of Colorado

12:00 p .m . - 1:30 p .m . Lunch1:30 p .m . - 2:30 p .m . Maternal Obesity and Fetal

Programming of Cardiometabolic RiskLaura Cox, PhDWake Forest University

2:30 p .m . - 3:00 p .m . Fetal Programming of Metabolism Through Novel Maternal FactorsMaria Belen Rabaglino, DVM, PhDCONICET

3:00 p .m . - 3:30 p .m . Congenital Heart Disease, Fetal Growth and the PlacentaHelen Jones, PhDUniversity of Cincinnati

3:30 p .m . - 4:00 p .m . Break4:00 p .m . - 5:00 p .m . Fetal hypoxia and cardiac programming

- integrated omics approachLubo Zhang, PhDLoma Linda University

8:30 a.m. – 5:00 p.m. Myometrium/Parturition/PREBIC Satellite MeetingAQUA CDJoint Satellite Symposium by Preterm Birth International Collaborative (PREBIC) and Parturition/MyometriumPREBIC Organizer: Ramkumar Menon, PhD The University of Texas Medical Branch at Galveston


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Parturition/Myometrium Organizers: Rachel Tribe, PhD King’s College London R. Ann Word, MD UT Southwestern Medical Center

Session 1: 8:30 a.m. – 12:00 p.m.Moderator: Hanns Helmer, MD Past President- PREBIC Medical University Vienna8:30 a.m. – 8:35 a.m. Welcome Address & Preterm Birth

International Collaborative - Update Nanbert Zhong, MD, PhDNew York State Institute for Basic Research in Developmental Disabilities

8:35 a.m. – 9:00 a.m. A Social Context on Preterm Birth in Developed CountriesSuzanne Tough, PhDUniversity of Calgary

9:00 a.m. – 9:30 a.m. The Genetics of Birth Timing: Insights from the Maternal GenomeLouis J. Muglia, MD, PhDUniversity of Cincinnati

9:30 a.m. – 10:00 a.m. Break10:00 a.m. – 10:30 a.m. Placental Insufficiency and Chronic

Hypoxia in Spontaneous Preterm LaborHui-Juan Zhang, MD, PhD Shanghai Jiao Tong University School of Medicine

10:30 a.m. – 11:00 a.m. The Inflammasome: Its Role In Placental and Fetal Membrane Inflammation, and in Preterm BirthVikki M. Abrahams, PhDYale University School of Medicine

Moderator: Elizabeth Bonney, MD, MPH University of Vermont


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11:00 a.m. – 11:45 a.m. PREBIC Key Note Lecture Exosome Engineering for Protein

Delivery: Principles and ApplicationsChulhee Choi, MD, PhDKAIST Cellex Life Sciences, Inc.

11:45 a.m. – 12:00 p.m. Discussion12:00 p.m. – 1:30 p.m. Lunch

Session 2: 1:30 p.m. – 5:00 p.m.Parturition and MyometriumModerators: Rachel Tribe, PhD King’s College London R. Ann Word, MD UT Southwestern Medical Center1:30 p.m. – 2:00 p.m. Identifying Conserved Regulatory

Pathways of Cervical Ripening by Comparative TranscriptomicsGunter Wagner, PhDYale University

2:00 p.m. – 2:30 p.m. Immunopathogenesis of Preterm BirthSenad Divanovic, PhDCincinnati Children’s Hospital Medical Center

2:30 p.m. – 3:00 p.m. An Accidental Discovery: N,N-Dimethylacetamide and Its Analogs

for the Prevention of Inflammation Driven Preterm BirthSandra Reznik, MD, PhDSt John’s University

3:00 p.m. – 3:30 p.m. Epigenetics of ParturitionAdrian Erlebacher, MD University of California San Francisco

3:30 p.m. – 4:00 p.m. BreakPreterm Birth International CollaborativeModerator: Sam Mesiano, PhD Case Western Reserve University Treasurer, PREBIC, Inc.


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4:00 p.m. – 4:30 p.m. Emerging Spectroscopic Techniques for the Prediction and Management of Preterm Birth Dilly OC Anumba, MBBS, FWACS, FRCOG, MD, LL.M (Medical Law) The University of Sheffield

4:30 p.m. – 5:00 p.m. Lessons from the Numom2b Study and Other NICHD Funded Clinical Preterm Birth ResearchUma M. Reddy, MD, MPHNational Institutes of Health

8:30 a.m. – 5:00 p.m. Ovarian Biology Satellite MeetingAQUA 310 ABPolycystic Ovary Syndrome: From Bench to BedsideOrganizers: Lubna Pal, MBBS, FRCOG, MS Yale School of Medicine Emre Seli, MD Yale School of Medicine8:30 a.m. – 9:30 a.m. Genetics of PCOS: From GWAS to

Molecular MechanismJoop Laven, MD, PhDErasmus University

9:30 a.m. – 10:00 a.m. Break10:00 a.m. – 11:00 a.m. Is PCOS an inflammatory disorder?

Antoni Duleba, MDUniversity of California, San Diego

11:00 a.m. – 11:30 a.m. Non-Coding RNAs in PCOS – A Link Between Metabolism and Ovarian FunctionAmanda Kallen, MDYale University

11:30 a.m. – 12:00 p.m. PCOS - Focus on AGE’s: RAGEZaher Merhi, MDNew York University

12:00 p.m. – 1:30 p.m. Lunch1:30 p.m. – 2:30 p.m. Polycystic Ovary Syndrome - The

Diagnostic Conundrum, and Implications for HealthNanette Santoro, MDUniversity of Colorado


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2:30 p.m. – 3:00 p.m. Aging, Menopause & PCOS - Challenges and ImplicationsLubna Pal, MDYale University

3:00 p.m. – 3:30 p.m. PCOS in Adolescence - When From... And Wither To?Marcelle Cedars, MDUniversity of California, San Francisco

3:30 p.m. – 4:00 p.m. Break4:00 p.m. – 5:00 p.m. Managing PCOS Related Infertility -

Optimizing Ovulation, Defining the Place, If Any, for Controlled Ovarian Hyperstimulation and Making a Case for ARTJuan Garcia-Velasco, MDUniversity of Madrid

8:30 a.m. – 5:00 p.m. Placental Satellite MeetingAQUA EFPlacental Association of the Americas Satellite Meeting Organizer: Thomas Jansson, MD, PhD University of Colorado Anschutz Medical Campus Supported by NICHD 1R13HD084096

Session 1: 8:30 a.m. – 11:30 a.m.Moderators: Fredrick Rosario, PhD University of Colorado Anschutz Medical Campus Helen Jones, PhD Cincinnati Children’s Hospital Medical Center At the Cutting Edge of Trophoblast Biology8:30 a.m. – 9:30 a.m. Plasticity and Placentation

Michael Soares, PhD University of Kansas/Children’s Mercy-Kansas City

9:30 a.m. – 10:00 a.m. Break10:00 a.m. – 11:00 a.m. Modeling Human Trophoblast

Differentiation Using Pluripotent Stem CellsMana Parast, MD, PhDUniversity of California San Diego


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11:00 a.m. – 11:30 a.m. Constructing Gene-Enhancer Networks to Understand Regulation of Diverse Trophoblast FunctionsGeetu Tuteja, PhDIowa State University

Session 2: 11:30 a.m. – 12:00 p.m.Moderators: Terry Morgan, MD, PhD Oregon Health Science UniversityThe Placental Atlas Tool11:30 a.m. – 12:00 p.m. The Placental Atlas Tool: A Web-based

NICHD ResourceJohn V Ilekis, PhDNational Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH)

12:00 p.m. – 1:30 p.m. LunchSession 3: 1:30 p.m. – 5:00 p.m.

Moderator: Yoel Sadovsky, MD, PhD Magee Women’s Research Institute Jessica Hebert, PhD Candidate Portland State UniversityThe Placenta as a Regulator of Fetal Brain Development1:30 p.m. – 2:30 p.m. Prenatal Exposures And Placental

Serotonin: A Pathway for the Developmental Programming of Mental DisordersAlexandre Bonnin, PhDUniversity of Southern California

2:30 p.m. – 3:30 p.m. Placental Gene Expression Mediates the Interaction Between Obstetrical History and Genetic Risk for SchizophreniaDanny Weinberger, MDJohns Hopkins University

3:30 p.m. – 4:00 p.m. Break4:00 p.m. – 4:30 p.m. Placental Epigenetics Establish Female

Resilience from Neurodevelopmental Dysfunction Following Prenatal StressBridget Nugent, PhDUniversity of Pennsylvania


Thursday, March 8

SCIENTIFIC PROGRAM SCIENTIFIC PROGRAM

12:00 p.m. – 1:00 p.m. Diversity and Inclusion Forum SAPPHIRE 400 AB Alden Landry, MD, MPH Beth Israel Deaconess Medical Center Office of Diversity Illusion and Community Partnership Harvard Medical School*Lunch is included for those who registered

6:30 p.m. – 8:00 p.m. Welcome ReceptionSAPPHIRE WEST FOYER/SAPPHIRE TERRACE

Join us for socializing, wine and light appetizers .

Thursday, March 87:00 a.m. – 6:00 p.m. Registration

SAPPHIRE WEST FOYER8:00 a.m. – 8:10 a.m. Welcome Address

SAPPHIRE A-JSandra T. Davidge, PhD2017 - 2018 SRI President

8:10 a.m. – 9:00 a.m. President’s Distinguished Lecture I How Cells Export Proteins

SAPPHIRE A-J Eligible for 2.0 AMA PRA Category 1 Credits™/ 2 .0 Category I College Cognate Credits

Randy W. Schekman, PhDProfessor of Molecular and Cell BiologyUniversity of California in Berkeley

9:00 a.m. – 10:00 a.m. New Investigator Plenary - Supported by the Past Presidents’ Fund SAPPHIRE A - J

Moderators: Sandra Davidge, PhD 2017 - 2018 SRI President James Roberts, MD 1996 - 1997 SRI Past President9:00 a .m . - 9:15 a .m . O-001: 3D Architecture of Endometrial

Glands in Relation to Stem Cell Organisation.Nicola Tempest, MBChB

9:15 a .m . - 9:30 a .m . O-002: Bone Marrow-Derived Progenitors Become Decidual Cells and Are Essential for Implantation and Pregnancy MaintenanceReshef Tal, MD, PhD

Wednesday, March 7, continued


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SCIENTIFIC PROGRAM

9:30 a .m . - 9:45 a .m . O-003: Intenatal Glucocorticoid Treatment Disrupts the Maternal and Fetal Methionine CycleAlexandros Mouratidis

9:45 a .m . - 10:00 a .m . O-004: Maternal Obesity is Associated with Altered Cardiac Structure and Function in Neonates: UPBEAT TEMPO Heart StudyEllie Battersby, BSc

10:00 a.m. – 12:00 p.m. Poster Session ISAPPHIRE C-PCoffee, biscuits and fruit will be served

12:00 p.m. – 1:30 p.m. Special Lunchtime Panel: How to Effectively Network and Collaborate Locally and Globally

SAPPHIRE A-JModerators: Marilyn J. Cipolla, PhD Stephen Matthews, PhDPanel Participants: Randy Schekman, PhD Ursula Kaiser, MD Marc E. A. Spaanderman, MD, PhD Lucilla Poston, PhD Diana Bianchi, MD Sarah Anne Robertson, PhD

1:30 p.m. – 3:30 p.m. Concurrent Oral Presentations I Clinical And Translational Perinatology I

SAPPHIRE 400 ABModerators: Ira M. Bernstein, MD Christie Walker, MD1:30 p.m. – 1:45 p.m. O-005: Conditional Xbp1 Deletion

Ameliorates Maternal Diabetes-Induced ER Stress and Neural Tube Defects through Restoration of miR-17 ExpressionPenghua Yang, Peixin Yang

1:45 p.m. – 2:00 p.m. O-006: Immediate Perioperative Predictors of Survival inTTTSJessica Ehrig, Nicholas Behrendt, Megan Lagueux, Kenneth W. Liechty, Michael V. Zaretsky, Timothy M. Crombleholme, Henry L. Galan

Thursday, March 8, continued


Thursday, March 8

SCIENTIFIC PROGRAM

2:00 p.m. – 2:15 p.m. O-007: Effects of Medication Intake in Early Pregnancy on the Fetal Fraction ofCell-Free DNAMaggie J. Kuhlmann-Capek, Prapti Singh, Luis Monsivais, Violetta Lozovyy, Lauren Gallagher, Nathan Kirsch, Elizabeth Florence, Victoria Petruzzi, Jeffrey Chang, Sofia Buitrago, Paul Walden, Benjamin Gardner, Mary Munn, Giuseppe Chiossi, Maged Costantine

2:15 p.m. – 2:30 p.m. O-008: Oral Steroids for Maturation of the Preterm Lung: Pharmacokinetic and Efficacy Data from a Sheep Model of PregnancyMatt Kemp, Augusto Schmidt, Haruo Usuda, Masatoshi Saito, Peter Eddershaw, Alan Jobe

2:30 p.m. – 2:45 p.m. O-009: Identification of a Novel 17OHPC Metabolite in Maternal and Cord BloodMolly J. Stout, Hideji Fujiwara, Kathiresan Krishnan, Douglas F. Covey, Daniel Ory, George A. Macones, Methodius G. Tuuli

2:45 p.m. – 3:00 p.m. O-010: Isolating Direct Adverse Effects of Betamethasone and Dexamethasone on the Fetal Heart: Studies in the Chick EmbryoTessa A. Garrud, Noor E. Teulings, Fiona G. Conlon, Sage G. Ford, Youguo Niu, Lisa M. Nicholas, Jan B. Derks, Sue E. Ozanne, Dino A. Giussani

3:00 p.m. – 3:15 p.m. O-011: IL-1 Receptor Antagonist Improves Trophoblast Invasion, Endothelial Development and ZIKV Sequelae in OffspringJun Lei, Meghan Vermillion, Bei Jia, Michael McLane, Mia Feller, Amanda Brown, Sabra Klein, Irina Burd

3:15 p.m. – 3:30 p.m. O-012: Cytokine Response to Zika Virus (ZIKV) Infection in Non-Pregnant and Pregnant Olive BaboonsSunam Gurung, Darlene N Reuter, Ashley Martin, Jamie Dubaut, Alisha Preno, James Papin, Dean Myers



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SCIENTIFIC PROGRAM

Gynecology IAQUA DModerators: Serdar Bulun, MD Shani Chibber, MSEB1:30 p.m. – 1:45 p.m. O-013: Establishment of a Mouse Model

of Deep Infiltrating EndometriosisXishi Liu, Dingmin Yan, Sun-Wei Guo

1:45 p.m. – 2:00 p.m. O-014: Activation of AKT by Wnt4 as a Novel Regulator of Uterine Leiomyoma Stem Cell FunctionShimeng Liu, Ping Yin, Stacy A. Kujawa, Serdar E. Bulun

2:00 p.m. – 2:15 p.m. O-015: Large-Scale Data Analysis on Endometriosis from the UK Biobank Reveals Novel Genetic Loci Nilufer Rahmioglu, James Cook, International Endometriosis Genomic Consortium (IEGC), Christian Becker, Andrew Morris, Krina Zondervan

2:15 p.m. – 2:30 p.m. O-016: Ulipristal Acetate Reverses Impaired Autophagy in Human Uterine Fibroids Ihor Atabiekov, Ayman Al-Hendy, Nahed Ismail, Abdeljabar El Andaloussi

2:30 p.m. – 2:45 p.m. O-017: Bone Marrow-Endometrial Stromal Cell Fusion in Experimental EndometriosisAya Tal, Reshef Tal, Shafiq Shaikh, Ramanaiah Mamillapalli, Hugh S. Taylor

2:45 p.m. – 3:00 p.m. O-018: Role of miR-451 in Regulating Endometrial Cell Proliferation Associated with Endometriosis. Niraj Joshi, Samantha Bond, Asgerally Fazleabas

3:00 p.m. – 3:15 p.m. O-019: Understanding the Genetic Basis of Transgender IdentityJohn G. Theisen, Mary S. Filchak, Viji Sundaram, Lynn P. Chorich, Megan E. Sullivan, Michael J. Friez, Hyung-Goo Kim, Lawrence C. Layman



Thursday, March 8

SCIENTIFIC PROGRAM

3:15 p.m. – 3:30 p.m. O-020: Next-Generation Sequencing Reveals Differentially Expressed Small Non-Coding RNAs (sncRNAs) in LeiomyomasTsai Der Chuang, Yeming Xie, Wei Yan, Omid Khorram

Parturition IAQUA CModerators: Abbie C. Johnson, PhD David A. MacIntyre, PhD 1:30 p.m. – 1:45 p.m. O-021: Electrical Impedance

Spectroscopy Predicts Preterm Delivery in Asymptomatic WomenVictoria Stern, Timothy J Healey, Zi-Qiang Lang, Brian H. Brown, Dilly O. Anumba

1:45 p.m. – 2:00 p.m. O-022: Pro-Inflammatory Cytokines and AP-1 Transcription Factors Mediate 20 alpha HSD Induction in Myometrium during LabourLubna Nadeem, Oksana Shynlova, Sam Mesiano, Stephen Lye

2:00 p.m. – 2:15 p.m. O-023: Cell-Free DNA Release by Mouse Fetal Membranes Mark Phillippe, Sharareh Adeli

2:15 p.m. – 2:30 p.m. O-024: Type I Interferons Instigate Fetal Demise after Zika Virus InfectionLaura J. Yockey, Kellie A. Jurado, Nitin Arora, Alon Millet, Tasfia Rakib, Kristin M. Milano, Andrew K. Hastings, Erol Fikrig, Yong Kong, Scott Weatherbee, Harvey J. Kliman, Carolyn B. Coyne, Akiko Iwasaki

2:30 p.m. – 2:45 p.m. O-025: Rapid Mucosal Metabolome Profiling by Desorption Electrospray Ionization MS (DESI-MS) for Prediction of Preterm Pre-Labour Rupture of Membranes (PPROM)Holly V. Lewis, Pamela Pruski, Richard G. Brown, Lindsay Kindinger, Yun Lee, Phillip Bennett, Zoltan Takats, David MacIntyre



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SCIENTIFIC PROGRAM

2:45 p.m. – 3:00 p.m. O-026: Immune Cells in Crosstalk with the Placental Microbiome - How Fusobacterium Nucleatum Affects Macrophage Function and Its Trophoblast InteractionRebekka Einenkel, Damián O. Muzzio, Jens Ehrhardt, Martha Heusler, Marek T. Zygmunt

3:00 p.m. – 3:15 p.m. O-027: CD161 Promotes Prenatal Immune Suppression of Pro-Inflammatory PLZF+

T CellsJoanna Halkias, Elze Rackaityte, Ventura Mendoza, Trevor Burt

3:15 p.m. – 3:30 p.m. O-028: Cervical Gene Delivery of Human Beta-Defensin-3 (HBD-3) Reduces E.coli K1 Ascending Infection and Increases the Proportion of Live Births in Pregnant MiceNatalie Suff, Rajvinder Karda, Jo Ng, Dany Perocheau, Mona Bajaj-Elliott, Suzanne M.K. Buckley, Simon N. Waddington, Donald Peebles

Placenta IAQUA ABModerators: Laura Brouwers, MD Nicholas P. Illsley, D.Phil1:30 p.m. – 1:45 p.m. O-029: Altered Placental Expression of

Candidate Blood Markers of Severe Fetal Growth Restriction is Driven by Hypoxia Natasha De Alwis, Sally Beard, Natalie Binder, Tu’uhevaha Kaitu’u-Lino, Susan Walker, Stephen Tong, Natalie J. Hannan

1:45 p.m. – 2:00 p.m. O-030: Lysophosphatidylcholine; a Critical Form of Fatty Acids in Fetal Circulation Veronique Ferchaud-Roucher, Elena Silva, Thomas Jansson, Theresa L. Powell

2:00 p.m. – 2:15 p.m. O-031: Omega-3 Polyunsaturated Fatty Acids Inhibit Trophoblast Inflammasome Activation and Preterm BirthChie-Pein Chen, Chia-Yu Chen, Chang-Ching Liu, Cheng-Yi Chen



Thursday, March 8

SCIENTIFIC PROGRAM

2:15 p.m. – 2:30 p.m. O-032: Longitudinal Study of Loss of Imprinting in First Trimester CVS Samples Compared to TermJonathan Riel, Maya Kappil, Jia Chen, Luca Lambertini, QIan Li, Yula Ma, Ronald Wapner, William Grobman, Men-Jean Lee

2:30 p.m. – 2:45 p.m. O-033: Syndecan-4 Regulates Extravillous Cytotrophoblast Cell Migration by Coordinating Protein Kinase C-Alpha ActivationMariyan Jeyarajah, Brianna Kops, Gargi Jaju, Stephen Renaud

2:45 p.m. – 3:00 p.m. O-034: Maternal Angiotensinogen and Fetal Sex Affect Placental Bed Angiogenesis in Mouse Model of Fetal Growth Restriction Jessica F. Hebert, Allison Felker, Terry K. Morgan

3:00 p.m. – 3:15 p.m. O-035: Changes in the Epigenetic Landscape Reveal Genes Crucial for Human Trophoblast Differentiation Youn-Tae Kwak, Sribalasubashini Muralimanoharan, Carole R. Mendelson

3:15 p.m. – 3:30 p.m. O-036: Evaluation of Diffusion MRI Metrics to Assess Placental Structure and FunctionAnna McCormick, Thomas Steigerwald, Robert Wujek, Melissa Prah, Kevin Boyd, Nghia Vo, Judith Hibbard, Kathleen Schmainda

Preeclampsia IAQUA EFModerators: Yoel Sadovsky, MD Floor Spaans, PhD1:30 p.m. – 1:45 p.m. O-037: Targeted Nanoparticles for

Delivery of sFlt-1e15a-Specific siRNA to the Placental Syncytiotrophoblast; a Novel Therapy for Pre- Eclampsia? Chloe Logue, Susan Greenwood, Stephen Tong, Natalie Hannan, Lynda K. Harris



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SCIENTIFIC PROGRAM

1:45 p.m. – 2:00 p.m. O-038: Lysosome Biogenesis and Exocytosis is Augmented in Preeclampsia Leonardo Ermini, Jonathan Ausman, Martin Post, Isabella Caniggia

2:00 p.m. – 2:15 p.m. O-039: Circulating mRNA Coding Adrenomedullin is Decreased in Women Destined to Develop Pre-Eclampsia and May Be of Placental and/or Endothelial OriginCarole-Anne Whigham, Teresa MacDonald, Sue Walker, Natalie Hannan, Ping Canon, Tuong Vi Nguyen, Stephen Tong, Tu’uhevaha Kaitu’u- Lino

2:15 p.m. – 2:30 p.m. O-040: Regulatory T Cells Regulate Uterine Artery Function to Impact Fetal Growth Alison S. Care, Stephane L. Bourque, Jude S. Morton, Emma P. Hjartarson, Sarah A. Robertson, Sandra T. Davidge

2:30 p.m. – 2:45 p.m. O-041: Can Maternal Vascular Lesions in the Placenta Predict Severity and Recurrence of Hypertensive Disorders of Pregnancy? Alisse Hauspurg, Vanessa Assibey-Mensah, W. Tony Parks, Arun Jeyabalan, James M. Roberts, Janet Catov

2:45 p.m. – 3:00 p.m. O-042: Flow Mediated Dilation; the Effect of Aging in Women with a History of Vascular Complicated and Uncomplicated Pregnancy Veronica A. Lopes van Balen, Chahinda Ghossein-Doha, Julia J. Spaan, Sander M.J. van Kuijk, Arnold P. Hoeks, Koen D. Reesink, Marc E.A. Spaanderman

3:00 p.m. – 3:15 p.m. O-043: Reduced Retinoic Acid in Preeclamptic Decidua Augustine Rajakumar, Martina Badell, Maureen Kane, Hongyan Qu, Robert N. Taylor, Neil Sidell



Thursday, March 8

SCIENTIFIC PROGRAM

3:15 p.m. – 3:30 p.m. O-044: Placental Uric Acid Transport System and Its Impact on Fetal Development Benjamin P. Lüscher, Philipp Schneider, Daniel Surbek, Marc U. Baumann

Reproductive Biology ISAPPHIRE 410 ABModerators: Sonia Herraiz, PhD Paolo Francesco Rinaudo, MD, PhD1:30 p.m. – 1:45 p.m. O-045: Molecular Control of Steroid

Hormone Production via Post-Transcriptional Regulation of the Steroidogenic Acute Regulatory Protein by the lncRNA H19Yong Chen, Chunrong Qin, Xia Xi, Amanda N. Kallen

1:45 p.m. – 2:00 p.m. O-046: Human Embryo-Derived Extracellular Vesicles Contain RNAs Involved in Embryogenesis and Can Modify the Endometrial Cell Transcriptomic Profile Upon Incorporation Elisa Giacomini, Riccardo Vago, Sofia Makieva, Dejan Lazarevic, Sabrina Minetto, Enrico Papaleo, Paola Viganò

2:00 p.m. – 2:15 p.m. O-047: Correlating Transcriptome and DNA Methylome Changes in Human Oocyte MaturationBo Yu, Naresh Jayavelu, Shannon Ferrell, Genevieve Neal-Perry, Timothy Schimmel, Jacque Cohen, R. David Hawkins

2:15 p.m. – 2:30 p.m. O-048: Epigenetic Clock Model of Somatic Aging Accurately Predicts Chronologic Age When Applied to White Blood Cells But Not Cumulus Cells in Reproductive Age WomenScott J. Morin, Xin Tao, Jenna Bedard, Jessica Landis, Yiping Zhan, Richard Scott, Emre Seli



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SCIENTIFIC PROGRAM

2:30 p.m. – 2:45 p.m. O-049: Loss of the Grb2 Associated Binding Protein 3 is Associated with Poor Uterine NK Cell Proliferation and Placental Accreta in MiceAnna Sliz, Kristin Lampe, Alzbeta Godarova, Helen Jones, Kasper Hoebe

2:45 p.m. – 3:00 p.m. O-050: LPS-Exposed Fetal Membranes Activate Neutrophils and Increase Neutrophil Extracellular Trap FormationMancy Tong, Julie A. Potter, Gil Mor, Vikki M. Abrahams

3:00 p.m. – 3:15 p.m. O-051: Peri-Implantation Progesterone Determines Regulatory T Cell Competence to Impact Late Gestation Pregnancy Outcome in Mice Sarah A. Robertson, Ella S. Green, Shaun R. McColl, Lachlan M. Moldenhauer

3:15 p.m. – 3:30 p.m. O-052: Role of WNT/CTNNB1 Pathway in Differentiation of Human Induced Pluripotent Stem Cells to Endometrial Stroma-Like CellsKaoru Miyazaki, Matthew T. Dyson, John S. Coon, Tetsuo Maruyama, Serdar E. Bulun

3:30 p.m. – 4:00 p.m. Coffee BreakSAPPHIRE WEST FOYER

4:00 p.m. – 6:00 p.m. Mini Symposia I Viral Infections in Pregnancy: When the Fetus is Caught in the Cross-Fire AQUA AB Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: Kristina Adams Waldorf, MD Michelle Silasi, MD4:00 p.m. – 4:30 p.m. The Placenta as the Front Line and

Battleground for Viral Infections: Lessons from Studying the Zika VirusIndira Mysorekar, PhD



Thursday, March 8

SCIENTIFIC PROGRAM

4:30 p.m. – 5:00 p.m. The Fetus Under Siege: Maternal Cytomegalovirus Infections During PregnancyKaren Racicot, PhD

5:00 p.m. – 5:30 p.m. Viral Injury of the Fetal Brain: Ceasefire at the Expense of Normal Development?Irina Burd, MD, PhD

5:30 p.m. – 6:00 p.m. Our War on the Zika Virus: Big Teams, Animal Models, and How We End the EpidemicPeta Grigsby, PhD

Endometrial Antecedents of Adverse Pregnancy Outcomes AQUA C

Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate CreditsModerators: Kirk P. Conrad, MD Emiel D. Post Uiterweer, MD, PhD4:00 p.m. – 4:30 p.m. Emerging Role for Dysregulated

Decidualization in the Genesis of PreeclampsiaKirk P. Conrad, MD

4:30 p.m. – 5:00 p.m. Epigenetics of the Decidua in ParturitionAdrian Erlebacher, MD, PhD

5:00 p.m. – 5:30 p.m. Impact of Natural Killer Cell KIR Haplotype on Recurrent Miscarriages and Implantation FailureJuan Garcia-Velasco, MD

5:30 p.m. – 6:00 p.m. Uterine Immune Cell Contribution to Pre-eclamptic PathologyGuy Whitley, PhD

Autophagy and ReproductionAQUA D

Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: John Challis, PhD Alina Maloyan, PhD4:00 p.m. – 4:30 p.m. Uterus and Autophagy

Felice Petraglia, MD4:30 p.m. – 5:00 p.m. Trophoblast and Autophagy

Isabella Caniggia, MD, PhD



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5:00 p.m. – 5:30 p.m. Obesity, Autophagy and the PlacentaAlina Maloyan, PhD

5:30 p.m. – 6:00 p.m. Autophagy and ParturitionSteven S. Witkin, PhD

DNA Repair and Micro-RNA in Reproductive Aging and Gynecologic Diseases

AQUA EF Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: Shannon Hawkins, MD, PhD Kutluk Oktay, MD, PhD4:00 p.m. – 4:30 p.m. Role of BRCA Function and DNA Repair

in Reproductive AgingKutluk Oktay, MD, PhD

4:30 p.m. – 5:00 p.m. Targeting miRNA Pathways in Gynecologic DiseasesShannon Hawkins, MD, PhD

5:00 p.m. – 5:30 p.m. Role of microRNA and Long Noncoding RNA in SteroidogenesisAmanda N. Kallen, MD

5:30 p.m. – 6:00 p.m. Ageing, Menopause and DNA RepairJoop S.E. Laven, MD, PhD

SRI-SSR Joint Session: Assisted Reproductive Technologies and Future Health

SAPPHIRE 410 AB Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: Paolo Francesco Rinaudo, MD, PhD Monica Mainigi, MD4:00 p.m. – 4:30 p.m. Epidemiology of Children Conceived by

ARTBarbara Luke, ScD, MPH

4:30 p.m. – 5:00 p.m. Trophoblast Lineage Specification: Implications for Assisted ReproductionFrancesca Soncin, PhD

5:00 p.m. – 5:30 p.m. Genomic Imprint Regulation in Gametes and Early EmbryosMellissa RW Mann, PhD

5:30 p.m. – 6:00 p.m. The Effect of Culture on the Embryo Phenotype in the Bovine ModelMarc Andre Sirard, DVM, PhD



Thursday, March 8


Thursday, March 8, continued Environmental Exposures and Reproductive Outcomes

SAPPHIRE 400 AB Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: Thomas McElrath, MD, PhD Laura Goetzel, MD, MPH4:00 p.m. – 4:30 p.m. Endocrine Disruptors and Pregnancy/

Birth OutcomesVasantha Padmanabhan, PhD

4:30 p.m. – 5:00 p.m. Environmental Exposures and Ovulatory DisordersShruthi Mahalingaiah, MD

5:00 p.m. – 5:30 p.m. Associations Between High Phthalate and Bis-Phenol Exposures and the Risk of Preeclampsia and Pregnancy Associated HypertensionDavid Cantonwine, PhD

5:30 p.m. – 6:00 p.m. Environmental Chemical Exposures and Gestational Diabetes Risk: Epidemiological Evidence from High and Average Risk PopulationsTamarra James-Todd, PhD

6:15 p.m. – 7:45 p.m. Connection Corners - Collaboration GenerationSAPPHIRE WEST TERRACE New Investigators are invited to come meet and connect with Senior and Mid-Career Investigators about jobs, career advice or just some friendly banter . Drinks and light appetizers provided .Table #1, “Collaboration Generation” • SophiePetropoulous,PhD• JimRoberts,MD• KentThornburg,PhDTable #2, “Your First SRI Meeting” • SarahEngland,PhD• MurrayMitchell,DPhil,DSc• LesMyatt,PhD,FRCOGTable #3, “Your First SRI Meeting” • MarilynJ.Cipolla,PhD• YoelSadovsky,MD• JamesSegars,MD


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Thursday, March 8, continuedTable #4, “Meet the SRI Distinguished Lecturer”• UrsulaKaiser,MD• RandySchekman,PhDTable #5, “What Can a Mentor Do for You?” • ElizabethBonney,MD,MPH• SamMesiano,PhD• EmilySu,MDTable #6, “How to Become a Negotiation Pro!” • CharlesDucsay,PhD• TerryMorgan,MD,PhD• SarahRobertson,PhDTable #7, “Clinical Grantsmanship” • AymanAl-Hendy,MD,PhD• SerdarBulun,MD• KelleMoley,MDTable #8, “Basic Science Grantsmanship” • ShannonBainbridge,PhD• IanBird,PhD• StacyZamudio,PhDTable #9, “Careers Outside of Academia” • LisaHalvorson,MD• DianaMorgenstern,MD,FACP• ThomasZollnerTable #10, “Publish and Flourish!” • ErrolNorwitz,MD,PhD,MBA• RonMagness,PhD• BoYu,MDTable #11, “Combining Science With Clinical Work” • Christy-LynnCooke,MD,PhD• AsmaKhalil,MDres,MRCOG,MSc(epi)• HughTaylor,MDTable #12, “Creating Your Network” • JohnChallis,PhD,FRCOG,FRSC• EunLee,PhD• StephenMatthews,PhDTable #13, “Mindfulness in Academia” • PhillipBennett,MD,PhD• PerrieO’Tierney-Ginn,PhD• EmreSeli,MD


Friday, March 9

SCIENTIFIC PROGRAM

Table #14, “Communicating Science to the Public” • JessicaHebert• HelenJones,PhD• ClaireRoberts,PhD

Friday, March 97:00 a.m. – 6:00 p.m. Registration

SAPPHIRE WEST FOYER8:00 a.m. – 9:00 a.m. President’s Distinguished Lecture II

SAPPHIRE A-J Eligible for 1.0 AMA PRA Category 1 Credits™/ 1 .0 Category I College Cognate Credits Genetic and Molecular Pathways Controlling Puberty: The Importance of Collaboration in Translational Research

Ursula B. Kaiser, MDChief, Division of Endocrinology, Diabetes and HypertensionHarvard Medical School

9:00 a.m. – 11:00 a.m. Poster Session II SAPPHIRE C-P

Coffee, biscuits and fruit will be served 11:00 a.m. – 12:30 p.m. Concurrent Oral Presentations II Developmental Programming I

SAPPHIRE 410 AB Moderators: Peter W. Nathanielsz, MD, PhD, ScD Barbara S. Verstraeten, MD11:00 a.m. – 11:15 a.m. O-053: Transcriptional Mechanisms

of Sex-Specific Postnatal Cardiac Dysfunction Programmed by Maternal Obesity in Mice Owen R. Vaughan, Fredrick J. Rosario, Theresa L. Powell, Thomas Jansson

11:15 a.m. – 11:30 a.m. O-054: Thyroid Hormone Stimulates Cardiomyocyte Metabolic Maturation in the Late Term Sheep HeartNatasha Chattergoon, Samantha Louey, Sonnet Jonker, George Giraud, Kent Thornburg



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SCIENTIFIC PROGRAM

11:30 a.m. – 11:45 a.m. O-055: Cardiovascular Susceptibility of Adult Male and Female Offspring Born to Advanced Maternal Aged Rat DamsAmin Shah, Christy L. Cooke, Jude S. Morton, Anita Quon, Sandra T. Davidge

11:45 a.m. – 12:00 p.m. O-056: F2 Fetal Nephron Number Benefits of Endurance Exercise Training for Females Born Small on a High Fat Diet Mary E. Wlodek, Jessica Briffa, Sogand S. Hosseini, Viktoria Richter, Dayana Mahizir, Kristina Anevska, Glenn D. Wadley, Deanne H. Hryciw, Karen M. Moritz

12:00 p.m. – 12:15 p.m. O-057: Non-Invasive Biomarkers of Cardiovascular Dysfunction in Adult Offspring Programmed by Developmental Hypoxia Rama Lakshman, Ana-Mishel Spiroski, Michael P. Murphy, Dino A. Giussani

12:15 p.m. – 12:30 p.m. O-058: Developmental Programming of Circulating Cortisol and Its Receptor in the Aorta of Late Gestation Fetuses of Obese, Undernourished, Control MothersCun Li, Hillary F. Huber, Dongbin Xie, Peter W. Nathanielsz

Fetus IAQUA C Moderators: Maureen Keller-Wood, PhD Miguel A. Zarate, PhD, DVM11:00 a.m. – 11:15 a.m. O-059: Inhibition of mTOR, Activation of

Amino Acid Response (AAR) and IGFBP-1 Hyperphosphorylation, in the Fetal Liver Precede the Development of IUGR in Baboons Following Maternal Nutrient RestrictionA. Sutherland, C. Li, P. Nathanielsz, T. Jansson, M. Gupta



Friday, March 9

SCIENTIFIC PROGRAM

11:15 a.m. – 11:30 a.m. O-060: What’s That Smell? First Evidence of Cardio- Protective Actions of Hydrogen Sulphide in the Developing HeartRita M. Hess, Youguo Niu, Tess A. Garrud, Kimberley J. Botting, Sage G. Ford, Dino A. Giussani

11:30 a.m. – 11:45 a.m. O-061: Loss of Uncoupling Protein 2 Explains Hyper-Insulin Secretion Following Persistent Adrenergic Receptor Signaling in Fetal Sheep Islets Amy Kelly, Melissa Davis, Leticia Camacho, Hailey Davenport, Nathan Steffens, Sean Limesand

11:45 a.m. – 12:00 p.m. O-062: Chronic Leucine Supplementation Potentiates Glucose Stimulated Insulin Secretion in Fetal SheeP Brit H. Boehmer, Laura D. Brown, Stephanie R. Wesolowski, William W. Hay, Jr., Paul J. Rozance

12:00 p.m. – 12:15 p.m. O-063: Day 5 vs. Day 6 Blastocysts: Early Time Lapse Markers Differ But There Are Similar Rates of Euploid EmbryosDana Kimelman, Ijeoma Okeigwe, Rafael Confino, Jaclyn Lambe-Steinmiller, Edmond Confino, Lee Shulman, Jared Robins, John Zhang, Mary Ellen Pavone

12:15 p.m. – 12:30 p.m. O-064: Excess Maternal Cortisol Alters Placental and Fetal Cardiac Metabolism at TermJacquelyn Walejko, Serene Joseph, Arthur Edison, Maureen Keller-Wood

Friday, March 9, continued


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SCIENTIFIC PROGRAM

Gynecology IIAQUA EF Moderators: Asgi T. Fazleabas, PhD Ijeoma Okeigwe, MD, MPH 11:00 a.m. – 11:15 a.m. O-065: PD-L1 Expression is Regulated

by Med12 and INF-γ in Human Uterine FibroidsAbdeljabar El Andaloussi, Prosper Igboeli, Sunil Halder, Ayman Al-Hendy, Nahed Ismail

11:15 a.m. – 11:30 a.m. O-066: H19 LncRNA Regulates Fibroids-Associated Gene Expression via Both Posttranscriptional and Epigenetic Mechanisms Tiefeng Cao, Na Zhang, Martin Mueller, Pinar Kodaman, Hugh Taylor, Yingqun Huang

11:30 a.m. – 11:45 a.m. O-067: GATA2 in Normal Endometrium and GATA6 in Endometriosis Are Associated with Genome- Wide H3K27ac Histone Modification and Active Transcription of Genes Essential for Tissue PhenotypesChristia Angela Sison, Shimeng Liu, Serdar E. Bulun, Matthew T. Dyson

11:45 a.m. – 12:00 p.m. O-068: Caloric Restriction Dramatically Stalls Lesion Growth in Mice with Induced EndometriosisSun-Wei Guo, Bo Yin, Xishi Liu

12:00 p.m. – 12:30 p.m. O-069: miR-451a-c-MYC Pathway Regulation of 60S Acidic Ribosomal Protein P1 (RPLP1) Expression: A Novel Pathway in Endometriotic Lesion Tissue Survival Zahraa Alali, Tommaso Falcone, Warren B. Nothnick

12:15 p.m. – 12:30 p.m. O-070: Prostaglandin E2 Signaling and Epigenetic Regulation of Proapoptotic miRNA15a in EndometriosisJoe A. Arosh, Jone A. Stanley, Kaylon Bruner-Tran, Kevin K. Osteen, Sakhila K. Banu



Friday, March 9

SCIENTIFIC PROGRAM

Maternal Biology And Health AQUA AB Moderators: K. Joseph Hurt, MD, PhD Ronald R. Magness, PhD11:00 a.m. – 11:15 a.m. O-071: Low Intensity Physical Activity

May Protect against Spontaneous Preterm Labor through IL10 Pathways Valerie Steckle, Oksana Shynlova, Ryan Seeto, Sheryl Hewko, Alan Bocking, Stephen Lye

11:15 a.m. – 11:30 a.m. O-072: Piezo1 Cation Channels: A Role in the Regulation of Uteroplacental Blood Flow? Nga Ling Ko, Natalia Gokina, Liam John, George Osol

11:30 a.m. – 11:45 a.m. O-073: Cardiovascular Risk Assessment and Follow-Up of Women after Hypertensive Disorders of PregnancyRachel A. Gladstone, Jessica Pudwell, Graeme N. Smith

11:45 a.m. – 12:00 p.m. O-074: Multiomics Analysis of the Immunome, Transcriptome, Microbiome, Proteome, Metabolome in Term PregnancySajjad Ghaemi, Martin Angst, Brice Gaudilliere, Nima Aghaeepour, On behalf of the March of Dimes Prematurity Center at Stanford University (47 coauthors)

12:00 p.m. – 12:15 p.m. O-075: Pregnancy-Augmented Uterine Artery CBS/H2S Biosynthesis is Downregulated in the Rat Model of Preeclampsia Induced by Reduced Uterine Perfusion Pressure (RUPP)Thomas J. Lechuga, Jing Zhou, Guofeng Yang, Nicole A. Nguyen, Sassi Sarnthiyakul, Fengying Xing, Yao Li, Xuejin Chen, Dongbao Chen

12:15 p.m. – 12:30 p.m. O-076: Impaired Function of Cerebral Parenchymal Arterioles in Experimental PreeclampsiaAbbie Johnson, Marilyn J. Cipolla



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SCIENTIFIC PROGRAM

Parturition II AQUA D Moderators: Stephen J. Lye, PhD Lynne Sykes, BSc, MBBS, PhD 11:00 a.m. – 11:15 a.m. O-077: Potential Role of Vitamin D

Metabolism in the Timing of BirthAlina P. Montalbano, Ailing Yang, Carole R. Mendelson

11:15 a.m. – 11:30 a.m. O-078: FKBP5 Gene Depletion Prevents Maternal Stress-Induced Preterm Birth (PTB) and Fetal Growth Restriction (FGR)Ozlem Guzeloglu-Kayisli, Kellie Larsen, Sefa Arlier, Nihan Semerci, Frederick Schatz, Umit Kayisli, Charles Lockwood

11:30 a.m. – 11:45 a.m. O-079: Labor-Associated Genes Are Marked by Bivalent Histone Modifications in the AmnionCarolyn M. Mitchell, Jonathan J. Hirst, Murray D. Mitchell, Henry G. Murray, Tamas Zakar

11:45 a.m. – 12:00 p.m. O-080: Gestational Profiling of Mouse Plasma Exosomes Reveals Inflammatory Biomarkers Increase Prior to ParturitionSamantha Sheller-Miller, Ramkumar Menon

12:00 p.m. – 12:15 p.m. O-081: The Unfolded Protein Response Regulates Inflammatory IL6 Production in the Pregnant Uterine Myocyte in the Absence of a Microbial Infection Chandrashekara Kyathanahalli, Sonia Hassan, Pancharatnam Jeyasuria, Jennifer Condon

12:15 p.m. – 12:30 p.m. O-082: Inflammation-Induced Preterm Birth Initiates Placental Immune Response Distinct from Placental Immunobiology at Term Emma L. Lewis, Guillermo Barila, Amy G. Brown, Paige M. Porrett, Michal A. Elovitz



Friday, March 9

SCIENTIFIC PROGRAM

Reproductive Endocrinology And Infertility ISAPPHIRE 400 AB Moderators: Nataki C. Douglas, MD, PhD Patricia T. Jimenez, MD11:00 a.m. – 11:15 a.m. O-083: Phytoestrogens (Soy-Derived

Metabolites) May Act Like Endometrial Disruptors Altering Decidualization of Human Endometrial Stromal Cells Silvia Perez, Stefania Salsano, Alicia Quiñonero, Francisco Dominguez

11:15 a.m. – 11:30 a.m. O-084: Peripheral Blood NK Cytotoxicity Levels as a Biomarker in Non-Pregnant and Pregnant Women with Reproductive Failure Maria D. Salazar Garcia, Rachel Reed, Youssef Hussein, Haidy Elazzamy, Annie Skariah, Svetlana Dambaeva, Alice Gilman-Sachs, Kenneth Beaman, Joanne Kwak-Kim

11:30 a.m. – 11:45 a.m. O-085: FSH Signaling is Augmented by AKAP13Ashlie Sewdass, Paul H. Driggers, Kamaria C. Vaught, James H. Segars

11:45 a.m. – 12:00 p.m. O-086: Mitochondrial Function in PCOS Oocyte is Affected More by Prenatal Androgen Than by Adult Androgen ExposureNeil R. Chappell, Beth Zhou, William E. Gibbons, Amy Schutt, Chellakkan S. Blesson

12:00 p.m. – 12:15 p.m. O-087: Steroidogenic Factor 1 (SF-1) is Essential for Sertoli Cell Survival in the Developing Fetal TestisPrashanth Anamthathmakula, Chandra S. Miryala, Jennifer C. Condon, Pancharatnam Jeyasuria



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SCIENTIFIC PROGRAM

12:15 p.m. – 12:30 p.m. O-088: Stem Cell Therapy of Polycystic Ovary Syndrome (PCOS): Implantation of Human Bone Marrow Stem Cells Enhance Energy Expenditure and Improves Hyperandrogenemia in an Immune- Competent Severe PCOS Mouse Model Abdeljabar El Andaloussi, Prosper Igboeli, Mona Omar, Ayman Al-Hendy

12:30 p.m. – 2:00 p.m. Lunch and Learn Symposium I: Building Cohorts: Dream Big, Start Small. Practical Considerations in Reproductive Cohort Construction, Recruitment, Maintenance, Data Management, and their UtilitySAPPHIRE 410 ABModerators: Shruthi Mahalingaiah, MD Boston University James M. Roberts, MD Magee Women’s Research InstituteCreation of a Robust Cohort for Generalized Research into the Hypertensive Disorders of Pregnancy: Experience from IowaMark Santillan, MD, PhDUniversity of Iowa Hospitals and ClinicsHow to Create and Maintain a Longitudinal Pregnancy Cohort Recruited in the Clinical Environment: Experience from the LIFECODES Birth Cohort in BostonThomas McElrath, MD, PhDBrigham & Women’s HospitalSpecial Considerations and Challenges in the Development of Birth Cohorts in the Developing World: Experience from BrazilArundhathi Jeyabalan, MDUniversity of PittsburghCapturing the Maternal Exposome & Metabolome & Birth Outcomes in an Obstetrically Sourced Population. Experience from the MMIP CohortVasantha Padmanabhan, PhDUniversity of Michigan



Friday, March 9

SCIENTIFIC PROGRAM

12:30 p.m. – 2:00 p.m. Lunch and Learn Symposium II: Updates from NICHD: Strategic Planning, Funding and Global InitiativesSAPPHIRE A - JSpeaker: Diana Bianchi, MD National Institute of Child Health and Human Development

12:30 p.m. – 2:00 p.m. Pfizer - SRI President’s Presenter’s Awards Lunch *The Pfiizer - SRI President’s Presenter’s Awards Lunch is a Non-CME event

300 AB – AQUA LEVEL2:00 p.m. – 4:00 p.m. Mini Symposia II Emerging Reproductive Technologies and Therapeutic Editing AQUA AB Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: Emre Seli, MD Reshef Tal, MD, PhD2:00 p.m. – 2:30 p.m. The New Reproductive Technologies:

The Harbinger of All Things FutureEmre Seli, MD

2:30 p.m. – 3:00 p.m. Therapeutic Editing of the Genome of the EmbryoJon D. Hennebold, PhD

3:00 p.m. – 3:30 p.m. Spindle Nuclear Transfer in Oocytes with Mitochondrial DNA MutationZaher Merhi, MD

3:30 p.m. – 4:00 p.m. Novel Approaches to Study Cell-lineage Decisions in Preimplantation EmbryosSophie Petropoulos, PhD

SRI-ISSHP Joint Session: Preeclampsia: A life-long disorderAQUA C


Moderators: Ananth Karumanchi, MD Floor Spaans, PhD2:00 p.m. – 2:30 p.m. Mechanisms of Cardic Remodeling in

PreeclampsiaBasky Thilaganathan, MBBS

2:30 p.m. – 3:00 p.m. Anti-hypertensive Therapy – What’s Next?Peter Von Dadelszen, MD



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SCIENTIFIC PROGRAM

3:00 p.m. – 3:30 p.m. Preeclampsia in Low Resource Settings: How to Make a DifferenceTom Easterling, MD

3:30 p.m. – 4:00 p.m. Preeclampsia: A Life-long DisorderMark Brown, MD

Setting the Research Agenda for Transgender Medicine in 2018AQUA D


Moderators: John Randolph, Jr., MD Molly Moravek, MD2:00 p.m. – 2:30 p.m. Biologic Origins of Gender Identity

Stephen Rosenthal, MD2:30 p.m. – 3:00 p.m. Bowel and Bladder Consequences of

Cross-Sex Hormone TherapyMitch B. Berger, MD

3:00 p.m. – 3:30 p.m. Models for Studying Fertility in Transgender AdultsMolly Moravek, MD

3:30 p.m. – 4:00 p.m. Addition of Estradiol to Testosterone Therapy and Implications for Treating Transgender Youth in MiceLaura Goetz, MD/PhD Candidate

The Impact of Obesity on Reproduction and Transgenerational Health: Chicken or the Egg or the Sperm?AQUA EF


Moderators: Alex J. Polotsky, MD, MS Jaime Lo, MD2:00 p.m. – 2:30 p.m. Reproductive Hormones and Obesity

Alex J. Polotsky, MD, MS2:30 p.m. – 3:00 p.m. The Impact of Obesity on Oocyte

Emily Jungheim, MD, MS3:00 p.m. – 3:30 p.m. Obesity, Male Infertility, and the Sperm

EpigenomeJames Hotaling, MD

3:30 p.m. – 4:00 p.m. The Impact of Obesity on Placenta and Intrauterine GrowthBernardo J. Krause, Sr., PhD



Friday, March 9

SCIENTIFIC PROGRAM

New Frontiers in Perinatal Neuroprotection and RegenerationSAPPHIRE 410 AB


Moderators: Daniel Surbek, MD Anna Euser, MD, PhD2:00 p.m. – 2:30 p.m. Distinguishing Arterial Ischemic Stroke

from Neonatal Hypoxic-Ischemic EncephalopathyErnest Graham, MD

2:30 p.m. – 3:00 p.m. Stem Cell Therapy for Hypoxic-Ischemic Injury in the Preterm Brain: What Have We Learned from the Animal ModelDaniel Surbek, MD

3:00 p.m. – 3:30 p.m. Antibiotic treatment of infection-associated preterm birth and perinatal brain injuryMeredith Kelleher, PhD

3:30 p.m. – 4:00 p.m. Role of Stem Cell‐derived miRNA Containing Exosomes and Preimplantation Factor (sPIF) in Peripartum Neuroregeneration Martin Mueller, MD, PhD

Pregnancy Interventions and Outcomes in Vulnerable Populations SAPPHIRE 400 AB Eligible for 2.0 AMA PRA Category 1 Credits™ / 2 .0 Category I College Cognate Credits

Moderators: Roger Smith, MBBS, PhD Stephen Matthews, PhD2:00 p.m. – 2:30 p.m. Improving Outcomes Through Nurturing

CareStephen Lye, PhD

2:30 p.m. – 3:00 p.m. Pre-conceptual Interventions to Improve Child Health Outcomes in IndiaCaroline Fall, MBChB, DM, FRCP, FRCPCH

3:00 p.m. – 3:30 p.m. Cultural Approaches and their Outcome in a Longitudinal Pregnancy Cohort with Indigenous Australians: Gomeroi gaaynggalKym Rae, PhD



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SCIENTIFIC PROGRAM

3:30 p.m. – 4:00 p.m. Placental Consequences of Diet Westernization Among Alaskan NativesKent Thornburg, PhD

4:00 p.m. – 4:30 p.m. Coffee BreakSAPPHIRE West Foyer

4:30 p.m. – 6:00 p.m. Concurrent Oral Presentations III Epidemiology And Global Health

AQUA D Moderators: Janet M. Catov, PhD, MS Angela Kelley, MD4:30 pm. – 4:45 p.m. O-089: Early-Pregnancy Inflammatory

Markers and Preterm Birth Classified According to Placental Features Baiyang Sun, Marnie Bertolet, Hyagriv N. Simhan, W. Tony Parks, Janet M. Catov

4:45 p.m. – 5:00 p.m. O-090: Demographic Characteristics and Outcomes of Pregnancies among Homeless Women in CaliforniaAriana M. Spiegel, Lillian Sie, Katie B. Sherwin, Brad S. St. Martin, Anna I. Girsen, Gary M. Shaw, Henry C. Lee, Yasser Y. El-Sayed

5:00 p.m. – 5:15 p.m. O-091: Osteoarthritis and Reproductive History in the Women’s Health InitiativeAnge Wang, Nadine Zawadzki, Haley Hedlin, Manisha Desai, Lynn Westphal, Marcia L. Stefanick

5:15 p.m. – 5:30 p.m. O-092: The Association of Income and Race with Inflammation Patterns during PregnancyLauren Keenan-Devlin, Gregory Miller, William Grobman, Emma Adam, Jen Culhane, Pathik Wadhwa, Doug Williamson, Hy Simhan, Kristine Kuchta, Ann Borders

5:30 p.m. – 5:45 p.m. O-093: No Uptake of Maternity Care is Associated with Low Socioeconomic Status and Higher Maternal Health Care Expenses in the First Year after ChildbirthJacqueline Lagendijk, Eric A. Steegers, Jasper V. Been



Friday, March 9

SCIENTIFIC PROGRAM

5:45 p.m. – 6:00 p.m. O-094: Maternal Education Level and Risk of Adverse Perinatal Complications in Adolescent PregnanciesChristina A. Penfield, Deborah A. Wing, Megan Oakes, Aaron B. Caughey

Fetus II AQUA AB Moderators: Elsje C. Oostingh, MD Charles E. Wood, PhD4:30 p.m. – 4:45 p.m. O-095: Myoblast Proliferation,

Differentiation, Fusion into Myonuclei Are Reduced in the Skeletal Muscle of Intrauterine Growth Restricted Fetal Sheep Eileen I. Chang, Leanna M. Nguyen, Stephanie R. Wesolowski, Paul J. Rozance, William W. Hay, Jr., Laura D. Brown

4:45 p.m. – 5:00 p.m. O-096: Weak Cardiovascular Defence to Hypotensive Stress in the Chronically Hypoxic FetusBeth J. Allison, Kirsty L. Brain, Youguo Niu, Andrew D. Kane, Emilio A. Herrera, Kimberley J. Botting, Christine M. Cross, Nozomi Itani, Katie L. Skeffington, Dino A. Giussani

5:00 p.m. – 5:15 p.m. O-097: Effect of Sildenafil and Nifedipine on Placental Hemodynamics during Hypoxemia in a Chronic Sheep ModelLeena Alanne, Amarnath Bhide, Juulia Junno, Heikki Huhta, Merja Kokki, Mervi Haapsamo, Ganesh Acharya, Juha Räsänen

5:15 p.m. – 5:30 p.m. O-098: Ex Vivo Peroxisome Proliferator-Activated Receptor Gamma Activation Opposes Increased Vasoconstriction in Uterine Artery from High Altitude-Exposed Pregnant MiceSydney L. Coates, Ramon A. Lorca, Lorna G. Moore, Colleen G. Julian



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SCIENTIFIC PROGRAM

5:30 p.m. – 5:45 p.m. O-099: Administration of Magnesium Sulfate Inhibits LPS-Induced IL-1β Expression through P2X7 Receptor in Human Umbilical Vein Endothelial Cells Han Xie, Maide Ozen, Ghada Al Yousif, Michael W. McLane, Julia L. Clemens, Jun Lei, Irina Burd

5:45 p.m. – 6:00 p.m. O-101: Sex-Related Differences in Mitochondrial Function in Offspring Hearts Exposed to Prenatal HypoxiaLoren P. Thompson, Hong Song

Gynecologic Oncology SAPPHIRE 410 AB Moderators: Alessandro D. Santin, MD Jessica Vazquez 4:30 p.m. – 4:45 p.m. O-101: Remarkable In Vitro and In Vivo

Activity of IMGN853, an Antibody-Drug Conjugate Targeting Folate Receptor Alpha Linked to the Tubulin- Disrupting Maytansinoid DM4, in Biologically Aggressive (Type II) Endometrial Cancers Gary Altwerger, Elena Bonazzoli, Stefania Bellone, Tomomi Egawa-Takata, Gulden Menderes, Francesca Pettinella, Francesco Riccio, Jacqueline Feinberg, Luca Zammataro, Chanhee Han, Ghanshyam Yadav, Katherine Dugan, Ashley Morneault, Jose F. Ponte, Natalia Buza, Pei Hui, Serena Wong,Babak Litkouhi, Elena Ratner, Dan-Arin Silasi, Gloria S. Huang, Masoud Azodi, Peter E. Schwartz, and Alessandro D. Santin

4:45 p.m. – 5:00 p.m. O-102: Co-Occurrence of Somatic Mutations in Tumor Suppressor ARID1A and Estrogen Receptor Cofactor NRIP1 in Endometrial Cancer Zhigui Li, Oloruntoba I. Osagie, Gary L. Goldberg, Gloria S. Huang



Friday, March 9

SCIENTIFIC PROGRAM

5:00 p.m. – 5:15 p.m. O-103: Integrative Analysis of Multi-Omics Exosomal Data for Identifying Multi-Markers for Susceptibility to Chemotherapy in Ovarian Cancer Mona Alharbi, Andrew Lai, Dominic Guanzon, Shayna Sharma, Carlos Palma, Felipe Zuñiga, Gregory E. Rice, Lewis Perrin, John D. Hooper, Carlos Salomon

5:15 p.m. – 5:30 p.m. O-104: AXL Inhibition Improves Chemo Response in Gynecologic Serous CancersKatherine Fuh, Jeanne Quinn, Meg Palisoul, Molly Greenwade, Katina Massad, Lei Guo, Andrea Hagemann, Carolyn McCourt, Premal Thaker, Matt Powell, Dave Mutch

5:30 p.m. – 5:45 p.m. O-105: Deep Immunophenotyping Reveals Unique Immune Signature of Ovarian Cancer AscitesJessica Vazquez, Gladys Lopez, Melina Chavarria, Mildred Felder, Arvinder Kapur, Aleksandar K. Stanic, Manish Patankar

5:45 p.m. – 6:00 p.m. O-106: Identification of Somatic Genetic Alterations in Ovarian Clear Cell Carcinoma with Next Generation SequencingYusuke Shibuya, Hideki Tokunaga, Bin Li, Jun Yasuda, Nobuo Yaegashi

Gynecology III AQUA C Moderators: Valerie A. Flores, MD James H. Segars, MD4:30 p.m. – 4:45 p.m. O-107: PLIN2 Functions as a Novel Linker

between Progesterone Signaling and Metabolism in Uterine Leiomyoma CellsIjeoma Okeigwe, Serdar Bulun, Ping Yin

4:45p.m. – 5:00 p.m. O-108: IL-1β Stimulates BDNF in Human Endometriosis Stromal Cells: Model for NeuroangiogenesisJie Yu, Antonio MC Francisco, Bansari G. Patel, Eric Zou, J. Mark Cline, Sarah L. Berga, Robert N. Taylor



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SCIENTIFIC PROGRAM

5:00 p.m. – 5:15 p.m. O-109: Rare Synonymous Mutations Show Strong Association with EndometriosisHans M. Albertsen, Rakesh Chettier, Kenneth Ward

5:15 p.m. – 5:30 p.m. O-110: Early Life Exposure to Endocrine Disrupting Chemicals Induces Inflammation-Mediated DNA Damage in Myometrial Stem Cells Hoda E. Elkafas, Osama A. Badary, Rehab Kamel, Engy M. Elmorsy, Abdeljabar EL Andaloussi, Ayman Al-Hendy

5:30 p.m. – 5:45 p.m. O-111: Dexamethasone Improves Embryo Yield but Not Endometrial Outcomes in a Murine Model of Endometriosis Dennis T. Fujii, Laurel H. Gillette, Sem Chan, Richard O. Burney

5:45 p.m. – 6:00 p.m. O-112: Tanshinone IIA Reduces Lesional Growth and the Extent of Fibrosis in a Mouse Model of Deep Infiltrating EndometriosisXianjun Cai, Min Luo, Xishi Liu, Sun-Wei Guo

Preeclampsia II AQUA EF Moderators: James M. Roberts, MD Chi Zhou, PhD4:30 p.m. – 4:45 p.m. O-117: Molecular and Functional

Memory in Human Uterine NK Cells Following Pregnancy Moriya Gamliel, Debra S. Goldman-Wohl, Ronit Haimov-Kochman, Avraham Nahum, Ofer Mandelboim, Simcha Yagel

4:45 p.m. – 5:00 p.m. O-113: Circulating Microparticle Proteins Differ at 1O-12 Weeks Gestation in Pregnancies That Develop PreeclampsiaThomas Frederick McElrath, David Cantonwine, David Sarracino, Scott Peterman, Brian Brohman, Kevin Rosenblatt



Friday, March 9

SCIENTIFIC PROGRAM

5:00 p.m. – 5:15 p.m. O-114: Paternal Deficiency of Complement Component C1q Leads to Pregnancy-Specific Hypertension and Impaired Maternal Vascular Function: A Unique Pregnancy Model Robert W. Powers, Judith Brands, Marcia Gallaher

5:15 p.m. – 5:30 p.m. O-115: Hypoxia-Mediated LIN28B Downregulation Contributes to Preeclampsia Pathogenesis by Inhibiting Trophoblast Differentiation and Inducing InflammationJohn Canfield, Sefa Arlier, Ezinne Mong, John Lockhart, Jeffrey VanWye, Ozlem Guzeloglu- Kayisli, Frederick Schatz, Charles J. Lockwood, John Tsibris, Umit A. Kayisli, Hana Totary- Jain

5:30 p.m. – 5:45 p.m. O-116: Enhanced Angiogenic Potential of the Human Placental Microvascular Niche Yingchun Li, Shuhan Ji, Emily J. Su

5:45 p.m. – 6:00 p.m. O-118: IP-10 Supression by Histone Methylation is Mediated by cAMP and the PRC2 Complex in Uterine Stromal CellsMichelle Silasi, Yang Yang-Hartwich, Yuan You, Paulomi Aldo, Gil Mor

Reproductive Biology II SAPPHIRE 400 AB Moderators: Francisco Dominguez, PhD Ramakrishma Kommagani, PhD4:30 p.m. – 4:45 p.m. O-119: Analysis of the Dynamic

Changes in Chromatin Accessibility in Decidualizing Human Endometrial Stromal Cells Raffaella Lucciola, Pavle Vrljicak, Emma S. Lucas, Lauren Lansdowne, Nigel Dyer, Sascha Ott, Jan J. Brosens



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SCIENTIFIC PROGRAM

4:45 p.m. – 5:00 p.m. O-120: Extracellular Vesicles Secreted by the Human Endometrium Contain Specific DNA Cargo That Might Be Involved in Maternal-Embryonic CommunicationDavid Bolumar, Roberto Alonso, Inmaculada Moreno, María Herrero, Sergio Cabanillas, Felipe Vilella, Carlos Simón

5:00 p.m. – 5:15 p.m. O-121: Regeneration of Endometrial Receptivity by SDF-1 or Bone Marrow Derived Cells in Mice with Thin Endometrium Kyong Wook Yi, Ramanaiah Mamillapalli, Cagdas Sahin, Shafiq Shaikh, Reshef Tal, Hugh S. Taylor

5:15 p.m. – 5:30 p.m. O-122: Stem Cell-Secreted Paracrine Factors in Human Endometrial Regeneration Nuria López-Pérez, Xavier Santamaría, Patricia Díaz-Gimeno, Patricia Sebastian-Leon, Amparo Faus, José Remohí, Antonio Pellicer, Carlos Simón, Irene Cervelló

5:30 p.m. – 5:45 p.m. O-123: CSF3 Impacts Female Fertility; Acting on Both Endometrium and Embryo Tracey A. Edgell, Jemma Evans, Leah Lazzaro, Kendra Boyes, Meghana Sridhar, Sally Catt, Luk Rombauts, Beverley Vollenhoven, Lois Salamonsen

5:45 p.m. – 6:00 p.m. O-124: Enrichment of Putative Stem/Progenitor Cells from Human Myometrium and Fibroids Using Endometrial Stromal Stem/Progenitor Cell Markers Amanda Patterson, Jitu George, Anindita Chatterjee, Jose Teixeira



Saturday, March 10

SCIENTIFIC PROGRAM

6:00 p .m . - 7:30 p .m . 65th Anniversary President’s Address, Awards Ceremony with Wine, Beer and CheeseSAPPHIRE A-JPresidential AddressSandra Davidge, PhD, SRI President, 2017 - 2018Frederick Naftolin Award for Mentorship Award Presentation Gautam Chaudhuri, MD, PhDLifetime Distinguished Service Award PresentationJohn R.G. Challis,PhD, FRCOG, FRSC President’s Achievement Award PresentationMana Parast, MD, PhD Distinguished Scientist Award PresentationLucilla Poston, PhD

8:00 p.m. – 11:00 p.m. SRI 65th Anniversary PartyJOES CRAB SHACK

A ticketed event hosted at Joe’s Crab Shack featuring a performance by the new SRI Band - The Featles.

Saturday, March 10 7:00 a.m. – 1:00 p.m. Registration

SAPPHIRE WEST FOYER8:00 a.m. – 9:00 a.m. SRI Business Meeting

SAPPHIRE A-J All SRI members are invited and breakfast will be provided during the meeting . 9:00 a.m. – 9:30 a.m. SRI Grant Program Recipients Presentations

SAPPHIRE A-J9:00 a .m . - 9:15 a .m . Glucocorticoid Exposure of the

Developing Human Embryo: Reprogramming our Future GenerationsSophie Petropoulos, PhD, 2016 - 2017 SRI Early Career Grant Recipient

9:15 a .m . - 9:30 a .m . VEGF delivery rescues spiral artery remodeling in mouse model of placental insufficiency: investigating potential mechanismsTerry Morgan, MD, PhD, 2016 - 2017 SRI Bridge Grant Recipient



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9:30 a.m. – 11:30 a.m. Poster Session III SAPPHIRE C-P

Coffee, biscuits and fruit will be served Human Embryo Secretions Regulate Human Endometrial Adhesion via the Lnc RNA, PTENP1’s, Sponge Effect on Endometrial MicroRNA

Masashi Takamura, Kate Rainczuk, Carly Cuman, Luk Rombauts, Tiki Osianlis, Evdokia Dimitriadis

11:30 a .m . - 1:00 p .m . Concurrent Oral Presentations IV Clinical And Translational Perinatology II

AQUA AB Moderators: Dilly O. Anumba, MD, FRCOG, LLM Kathleen A. Pennington, PhD11:30 a.m. – 11:45 a.m. O-125: Sex Differences in Mesolimbic

Dopamine Signaling in a Mouse Model of Maternal Diet- Induced ObesityAndrea G. Edlow, Chang Xue, Emmanuel Pothos

11:45 a.m. – 12:00 p.m. O-126: Maternal Diet Modification Restores Placental Blood Flow in a Non-Human Primate Model of Diet-Induced Obesity Jamie Lo, Matthias Schabel, Victoria Roberts, Antonio Frias

12:00 p.m. – 12:15 p.m. O-127: Maternal Diabetes Suppresses Sox2ot Expression and CRISPR-Cas9 Editing on Sox2ot Gene Promoter Disrupts Its Expression Leading to Neural Tube Defects Daoyin Dong, E. Albert Reece, Wei-Bin Shen, Peixin Yang

12:15 p.m. – 12:30 p.m. O-128: Artificial Sweeteners during Pregnancy - Impact on Maternal Metabolic Health Jasmine F. Plows, Anna P. Ponnampalam, Mark H. Vickers, Clare M. Reynolds

12:30 p.m. – 12:45 p.m. O-129: Effects of Paternal BMI on Cord Blood Methylation Patterns: An Epigenome-Wide Association Study Nudrat Noor

Saturday, March 10, continued


Saturday, March 10

SCIENTIFIC PROGRAM

12:45 p.m. – 1:00 p.m. O-130: Aspirin: A Potential for Reducing Intrauterine Growth Restriction in Low-Risk Women Roxane Handal-Orefice, Maria Andrikopoulou, Stephanie Purisch, Russell Miller, Cynthia Gyamfi-Bannerman

Developmental Programming IISAPPHIRE 410 AB Moderators: Dino A. Giussani, PhD, ScD, FRCO Maria B. Rabaglino, MSc, PhD11:30 a.m. – 11:45 a.m. O-131: Aldosterone Plays an Important

Role in the Programming Effects of Antenatal Glucocorticoids in Sheep Jorge P. Figueroa, Cun Li, Jie Zhang, Peter W. Nathanielsz, Angela G. Massmann

11:45 a.m. – 12:00 p.m. O-132: Vascular Function is Altered via Sex-Specific Mechanisms in Aged Offspring Born from Dams of Advanced Maternal Age Christy-Lynn M Cooke, Alison S. Care, Raven D. Kirshenman, Anita L. Quon, Jude S. Morton, Sandra T. Davidge

12:00 p.m. – 12:15 p.m. O-133: Role of Nephrogenesis in Developmental Programming of Adult Blood Pressure and Nephron Number Elizabeth DuPriest, Jessica Hebert, Mayu Morita, Terry K. Morgan

12:15 p.m. – 12:30 p.m. O-134: Neurosteroid Therapy Following Preterm Birth in the Guinea Pig Ameliorates Neurological ImpairmentJulia Shaw, Hannah Palliser, Rebecca Dyson, Max Berry, Jonathan Hirst

12:30 p.m. – 12:45 p.m. O-135: Epigenetic DNA Methylation-Mediated Programmed Reduced Neural Stem Cell Proliferation and Differentiation in SGA Offspring Mina Desai, Guang Han, Michael G. Ross



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12:45 p.m. – 1:00 p.m. O-136: Size and Shape of the Baboon Corpus Callosum (CC) is Modified by Poor Maternal Nutrition in a Sex Dependent Manner, Demonstrating Early AgingJessica L. Joganic, Ronan Ledevin, Hillary F. Huber, Cun Li, Peter W. Nathanielsz, Geoffrey D. Clarke, Yann Heuze

Parturition III AQUA C Moderators: Jennifer C. Condon, PhD Kristin Marie Myers, PhD11:30 a.m. – 11:45 a.m. O-137: Shear Wave Elasticity Imaging

Detects Gradual Softening of the Pregnant Rhesus Macaque Cervix Ivan M. Rosado-Mendez, Lindsey C. Drehfal, Quinton W Guerrero, Andrew P. Santoso, Mark L. Palmeri, Helen Feltovich, Timothy J. Hall

11:45 a.m. – 12:00 p.m. O-138: Proliferative and Migratory Properties Reveals Metastate of Amnion Cells Mediated by Epithelial to Mesenchymal and Mesenchymal to Epithelial Transitions Lauren Richardson, Jayshil Trivedi, Ramkumar Menon

12:00 p.m. – 12:15 p.m. O-139: A Biomechanical Signature to Assess Cervical Extracellular Components in Term and Preterm Birth Charles Jayyosi, Nicole Lee, Shanmugasundaram Nallasamy, Alexandra Willcockson, Mala Mahendroo, Kristin Myers

12:15 p.m. – 12:30 p.m. O-140: Oxytocin Inhibits the Potassium Channel SLO2.1: A Novel Mechanism of Regulating Uterine ExcitabilityCelia M. Santi, Juan J. Ferreira, Alice Buttler, Richard Stewart, Ana Laura González-Cota, Pascale Lybaert, Chinwendu Amazu, Erin L. Reinl, Monali Wakle-Prabagaran, Lawrence B. Salkoff, Sarah K. England



Saturday, March 10

SCIENTIFIC PROGRAM Saturday, March 10, continued

12:30 p.m. – 12:45 p.m. O-141: T Type Ca2+ Channels May Play an

Essential Role in Uterine Contractility Sandy Li, Qunsheng Dai, Chad Grotegut, Thomas Price

12:45 p.m. – 1:00 p.m. O-142: The Efficacy of Aminophylline and Progesterone Co-Treatment to Suppress Human Myometrial Contractions during Prolonged Exposure Pei F. Lai, Roger C. Young, Rachel M. Tribe, Mark R. Johnson

Placenta II AQUA EF Moderators: Vicki L. Clifton, PhD Jessica F. Hebert, PhD Candidate 11:30 a.m. – 11:45 a.m. O-143: Gestational Testosterone

Excess Compromises Placental Milieu in a Sheep Model of Polycystic Ovary Syndrome Angela S. Kelley, Muraly Puttabyatappa, Yolanda R. Smith, Vasantha Padmanabhan

11:45 a.m. – 12:00 p.m. O-144: Direct Toxicity of Insulin on the Human Placenta and Protection by Metformin Mario Vega, Maurizio Mauro, Zev Williams

12:00 p.m. – 12:15 p.m. O-145: Multiparametric High Resolution Flow Cytometry Reveals Upregulation of Platelet-Specific Microvesicles in the First Trimester of Pregnancy Mayu Morita, Terry Morgan

12:15 p.m. – 12:30 p.m. O-146: Interactions between Placental Exosomes and Skeletal Muscle - Implication in Cell Metabolism in Gestational Diabetes Mellitus Soumyalekshmi Nair, Nanthini Jayabalan, Dominic Guanzon, Andrew Lai, Katherin Scholz- Romero, Omar Elfeky, Felipe Zuñiga, Emilio Diaz, David McIntyre, Gregory E. Rice, Martha Lappas, Carlos Salomon


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12:30 p.m. – 12:45 p.m. O-147: Hydroxychloroquine Treatment Inhibits ZIKV Infection in Placenta by Blocking ZIKV NS2B-NS3 Protease ActivityBrooke Liang, Ankur Kumar, Rajanish Giri, Indira U. Mysorekar

12:45 p.m. – 1:00 p.m. O-148: Human Decidual Cells (DCs) Express Proteins Required for ZIKA Virus (ZIKV) Cell Entry and Are Permissive for ZIKV Infection Ozlem Guzeloglu-Kayisli, Nihan Semerci, Kellie Larsen, Catherine Elzein, Frederick Schatz, Umit Kayisli, Charles Lockwood

Regenerative Medicine SAPPHIRE 400 AB Moderators: Valerie A. Flores, MD Mana M. Parast, MD, PhD 11:30 a.m. – 11:45 a.m. O-149: PreImplantation Factor

Promotes Neuroprotection by Modulating Long Non-Coding RNA H19 of the Neuronal Stem CellsMartin Mueller, Marialuigia Spinelli, Sara Ornaghi,reina Schoeberlein, Angelique Bordey, Daniel Surbek, Eytan Barnea, Michael Paidas

11:45 a.m. – 12:00 p.m. O-150: Bone-Marrow Derived Endometrial Cells Express Glucocorticoid Receptor Kavitha Krishnamoorthy, Amma Owusu-Akyaw, Laura T. Goldsmith, Sara S. Morelli

12:00 p.m. – 12:15 p.m. O-151: Fertility Rescue by Bone Marrow Derived Stem Cell Infusion Anna Buigues, Sonia Herraiz, Maria Marchante, Aaron J Hsueh, Antonio Pellicer


Saturday, March 10

SCIENTIFIC PROGRAM

12:15 p.m. – 12:30 p.m. O-152: Endometrial Mesenchymal Stromal/Stem Cells Modulate the Macrophage Response to Implanted Polyamide/Gelatin Composite Mesh in Immunocompromised and Immunocompetent Mice Saeedeh Darzi, James A Deane, Claudia Nold, Sharon L. Edwards, Shayanti Mukherjee, Shanti Gurung, Ker Sin Tan, Jerome A. Werkmeister, Caroline E. Gargett

12:30 p.m. – 12:45 p.m. O-153: Human Amniotic Fluid Stem Cells: A Novel Treatment Option for Neonatal Cerebral PalsyToshimitsu Otani, Daigo Ochiai, Marie Fukutake, Yushi Abe, Yu Sato, Youhei Akiba, Tadashi Matsumoto, Hirotaka Masuda, Kei Miyakoshi, Mamoru Tanaka

12:45 p.m. – 1:00 p.m. O-154: Maintenance of Undifferentiated Human Endometrial Mesenchymal Stem Cells by TGFβ Receptor Inhibition Reveals an Angiogenic and Anti-Inflammatory Phenotype Shanti Gurung, Sarah Williams, Jerome A. Werkmeister, Caroline E. Gargett

Reproductive Endocrinology And Infertility II AQUA D Moderators: Andrea Borini, MD Maria D. Salazar Garcia, MD11:30 a.m. – 11:45 a.m. O-155: MFN1 is Required for Follicle

Development, Oocyte Maturation, Female FertilityMan Zhang, Tianren Wang, Muhammed Burak Bener, Ecem Esencan, Richard Scott III, Emre Seli

11:45 a.m. – 12:00 p.m. O-156: Human Adipose Derived Stem Cells Improve Growth and Survival of Murine Primary Follicles in a Biomimetic Culture System Elizabeth S Constance, Claire E. Tomaszewski, Hong Zhou, Ariella Shikanov



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12:00 p.m. – 12:30 p.m. O-157: High Number of Ovarian Follicles Maintained after Ovarian Tissue Cryopreservation in Young Females with Cancer Requiring Gonadotoxic Treatment Mindy S. Christianson, Jacqueline Y. Maher, Erik W. Jenson, Qihong Wang, Jeffrey Lukish

12:15 p.m. – 12:30 p.m. O-158: A Cargo of Amplifiable Genomic DNA is Present in Human Preimplantation Embryo-Exported Extracellular Vesicles and Assessable for Mutation DetectionSofia Makieva, Francesca Spinella, Elisa Giacomini, Laura Corti, Anil Biricik, Francesco Fiorentino, Paola Viganò

12:30 p.m. – 12:45 p.m. O-159: Moved to Poster Session III12:30 p.m. – 12:45 p.m. O-159.2: First Trimester Global

Metabolomic Profile Differences in Pregnancies Conceived with In Vitro Fertilization (IVF)Tianyanxin Sun, Bora Lee, Tania L. Gonzalez, John Williams, III, Margareta D. Pisarska

12:45 p.m. – 1:00 p.m. O-160: Plasma microRNAs Identified as Novel Markers of Embryo Implantation Shirin Khanjani, Rumana Islam, Javairia Khalid, Vasso Terzidou, Stuart Lavery, Kim Sung Hye, Phillip R Bennett


Saturday, March 10

SCIENTIFIC PROGRAM

1:00 p.m. – 3:00 p.m. Hot Pizza and Hot Topics and Awards LuncheonSAPPHIRE A-JModerators: Emre Seli, MD Sarah England, PhD 1:00 p .m . - 1:15 p .m . The Immune Landscape after Local

Endometrial Injury in Recurrent Implantation FailureJerry Chan, Ryan Lee, Yie Hou Lee, Naomi McGovern, Florent Ginhoux, Xiang Wen Ng

1:15 p .m . - 1:30 p .m . Reduced ARID1A and High SIRT1 Levels are Uniquely Found in Ovarian Cancers Associated with EndometriosisBruce A. Lessey, Hanna E. Teasley, Anne Beesley, Larry E. Puls, Jeffrey Elder, Tae Hoon Kim, John Risinger, Steven L. Young, Jae-Wook Jeong

1:30 p .m . - 1:45 p .m . Genomic Interaction between Progesterone, cAMP, and Inflammation in Myometrial Cells to Control Human ParturitionZachary Stanfield, Peyvand Amini, Junye Wang, Lijuan Yi, Huiqing Tan, Mehmet Koyuturk, Sam Mesiano

1:45 p .m . - 2:00 p .m . Fetal and Placental Phosphoinositol 3-Kinase (PI3K) P110α Have Distinct Contributions in Regulating Resource Allocation to the Growing FetusJ. López-Tello, J. Khaira, L.C. Kusinski, W.N. Cooper, A. Andreani, I. Grant, E. Fernández, I. Sandovici, M. Constancia, A.N. Sferruzzi-Perri


March 6 - 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 59

POSTER GUIDE Posters will be displayed Thursday, Friday and Saturday in the Sapphire C - P Ballroom

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THANK YOU TO OUR 2018 POSTER JUDGESTerrence Allen, MBBS, MHS, FRCAMatthew L . Anderson, MD, PhDDilly O . Anumba, MD, FRCOG, LLMSamir N . Babayev, MDLaxmi V . Baxi, MDKarin J . Blakemore, MDSilvina M . Bocca, MD, PhD, HCLD,CCDerek S . Boeldt, PhDAlexandre U . Borbely, PhDLeah H . Bressler, MD, MPHErkan Buyuk, MDEgle Bytautiene Prewit, MD, PhDIsabella Caniggia, MD, PhDJanet M . Catov, PhD, MSJohn R .G . Challis, PhD, FRCOG, FRSCSetsuko K . Chambers, MDLinda Ruth Chambliss, MD, MPHStephen Charnock-Jones, PhDGregory M . Christman, MDChristy-Lynn M . Cooke, MD, PhDJohn S . Davis, PhDChristianne J .M . De Groot, MD, PhDAlan H . DeCherney, MDChristophe L . Depoix, PhDFrancisco Dominguez, PhDDaoyin Dong, PhDNataki C . Douglas, MD, PhDDonald J . Dudley, MDThomas R . Easterling, MDAndrea G . Edlow, MD, MScMichael J . Fassett, MDAntonio E . Frias, MDHilary S . Gammill, MDCaroline E . Gargett, PhDJennifer B . Gilner, MD, PhDLaura Goetzl, MD, MPHNardhy Gomez-Lopez, PhD

Maritza G . Gonzalez, MDStella Goulopoulou, PhDRavi Goyal, MD, PhDMichael G . Gravett, MDMarsha K . Guess, MD, MSCynthia Gyamfi-Bannerman, MD, MScNatalie J . Hannan, PhDShannon M . Hawkins, MD, PhDJessica Faith Hebert, BAHanns P . Helmer, Assoc .Prof .Denise G . Hemmings, PhDMeghan G . Hill, MBBSCalvin J . Hobel, MDMariko Horii, MDGloria S . Huang, MDHong-yuan Huang, MDK . Joseph Hurt, MD, PhDThomas B . Jansson, MD, PhDJuanita K . Jellyman, PhDArundhathi Jeyabalan, MDLeena T . Kadam, PhDBernardo J . Krause, PhDSeung-Yup Ku, MD, PhDSathish Kumar, DVM, PhDDeepak Kumar, MDWendy Kuohung, MDSatu Maarit Kuokkanen, MD PhDJoanne Y . Kwak-Kim, MD, MPHUwe Lang, MD, PhDMartha Lappas, PhDShannon K . Laughlin-Tommaso, MDMen-Jean Lee, MDSean W . Limesand, PhDIsa M . Lindgren, PhDShintaro Makino, MDChiara Mando, PhDClarence R . Manuel


THANK YOU TO OUR 2018 POSTER JUDGESKeiichi Matsubara, MD, PhDThomas Frederick McElrath, MD, PhDK .M .J . Menon, PhDSara Sinha Morelli, MD, PhDTerry Morgan, MD, PhDAmy P . Murtha, MDKristin Marie Myers, PhDShanmugasundaram Nallasamy, DVM, PhDNihar R . Nayak, DVM, PhDGenevieve S . Neal-Perry, MD, PhDChristopher J . Nold, MDWarren B . Nothnick, PhDCharlotte J . Oyston, MBChBVasantha Padmanabhan, MS, PhDLubna Pal, MBBS, FRCOG, MSMana M . Parast, MD, PhDR . Pavone, MD, MSWilliam J . Pearce, PhDKathleen A . Pennington, PhDJelmer R . Prins, MD, PhDMaria B . Rabaglino, PhDSusan D . Reed, MDTorsten M . Reinheimer, PhDVictoria H .J . Roberts, PhDMichael G . Ross, MD, MPHPaul J . Rozance, MDMaria D . Salazar Garcia, MDMark Santillan, MD, PhD Sarah Schalekamp-Timmermans, MD, PhDEmre Seli, MDBlesson C . Selvanesan, PhDDonna R . Session, MDDinesh M . Shah, MDAlireza A . Shamshirsaz, MDPanicos Shangaris, MBBCh, BAO, MScMarc E . Spaanderman, MD, PhDMichael Strug, DO, PhD

Kent L . Thornburg, PhDMancy Tong, PhD (Obstetrics & Gynecology)Rachel M . Tribe, PhDAbraham (Avi) Tsur, MDJan M .M . van Lith, MD, PhDBas B . Van Rijn, MD PhDIan M .Vasicka, MDFelipe Vilella, PhDJoris Vriens, ProfShannon D . Whirledge, PhD, MHSHung N . Winn, MD, JD, MBAVirginia D . Winn, MD, PhDDaliao Xiao, DVM, PhDQing Xue, MD, PhDBo Yu, MDStacy Zamudio, PhD


SRI GRANTS PROGRAMSRI is pleased to continue the SRI Grants Program and the International Training Grant Program . The Grants Program provides two $50,000 awards to current SRI members each year . The objective of the grants is to support the research of promising scientists who are beginning their indepen-dent research careers . The scope of the science can be basic, translational or clinical . It must be related to women’s health .

The International Training Grant provides three trainees, at $5,000 each, an opportunity to obtain research experience in an Institution outside of their home country for 4-8 weeks . Dr . Sandra Da-vidge, SRI President, the SRI Council and Grants Committee thank the following SRI members and distinguished guest scientists who served as expert reviewers for the 2018 SRI Grant applications .

Kristina Adams Waldorf, MDPaula Amato, MDIra Bernstein, MDKim Botting, PhDKaylon L . Bruner-Tran, PhDIsabella Caniggia, MD, PhDEileen Chang, PhDDongboa Chen, PhDJennifer Condon, PhDAnna David, PhDGernot Desoye, PhDJane Girling, PhDThomas Jansson, MD, PhDHelen Jones, PhDTu'uhevaha Kaitu'u-Lino, PhDJeff Keelan, PhDLouise Laurent, MD, PhDRon Magness, PhDAlina Maloyan, PhDCarole Ober, PhDKutluk Oktay, MD, PhDGeorge Osol, PhD

Mana Parast, MD, PhDSam Parry, MDBill Pearce, PhDJurgen Pollheimer, PhDRob Powers, PhDClaire Roberts, PhDR . Michael Roberts, PhDBo Rueda, PhDLaura Schulz, PhDDinesh Shah, MDRebecca Simmons, MDRobert Sokol, MDFrancesca Soncin, PhDJerry Strauss, MD, PhDHugh Taylor, MDStephen Tong, PhDCathy Vaillancourt, PhDMichael Varner, MDEuan Wallace, MDStephanie Wesolowski, PhDRuth Ann Word, MDChandra Yallampalli, DVM, PhD


The Society for Reproductive Investigation is pleased to be able to provide the following awards at our 2018 Annual Scientific Meeting:

President’s Plenary Award Recognizes the four highest ranked abstracts chosen for presentation at the President’s New Inves-tigator Plenary Session . The recipients of the award will each be presented with a $1,000 award at the Annual Meeting Awards Luncheon . These awards are supported by the SRI Past Presidents Fund .

Pfizer-SRI President’s Presenter’s AwardOriginally established in 1996 as the Wyeth President’s Presenter Award to recognize the 25 most meritorious oral abstracts submitted by individuals still in training . Fellows, and those in both pre and post-doctoral training, are eligible to receive the award . The 25 awardees will receive a certificate and a $1,000 award, and they and their training directors will be honored at the Annual Meeting Awards Luncheon . The Society has always sought a means by which to encourage young investigators to present their research at our meeting . We anticipate the SRI President’s Presenter’s Award will encourage more abstract submissions and higher quality abstracts by the very people who need encouragement to consider a research career .

Laxmi Baxi AwardEstablished in 2013 and will be awarded to PhD individuals only, who are either graduate students still in training or postdoctoral fellows within five years of their PhD degree . Two $1,000 travel awards will be given to the top abstracts in basic reproductive science and in translational reproductive science . The awardees will receive a plaque, award and they will be honored at the SRI Annual Meeting Awards Ceremony . This award is made possible by a generous, long-standing member of SRI, Dr . Laxmi Baxi, and was created to encourage young PhD trainees to present their research at our meeting .

Thomas McDonald AwardAcknowledges the highest ranked abstract by an in training investigator within the field of fetal neuroscience . This award honors the legacy of Dr . McDonald, whose immense contributions to the field of obstetrics and gynecology focused upon the neuroendocrinology of the developing fetus, placental function, fetal brain development, and the uterine contractility . The award will be presented at the Awards Ceremony during the SRI Annual Scientific Meeting .

Giorgio Pardi Foundation AwardsProvide a $1,000 monetary award to a Junior Scientist as well as the three best young worthy investigators coming from Italian Universities . The award winners will be presented at the Awards Ceremony during the SRI Annual Scientific Meeting .

2018 AWARDS


The SRI Travel Awards - New in 2018!The SRI Travel Awards were established in 2018 to support attendance of In-Training investigators at the Annual Meeting and recognize trainees for the high quality of their abstracts . A total of 50 awards will be given to intercontinental ($1,000), and continental (from the same continent as the location of the Annual Meeting) in training investigators ($500) . The awardees will be recognized at the Annual Meeting by having their names placed both on a sign, as well as on a slide projected throughout the meeting .

SRI In Training Investigator Poster AwardsInitiated at the 2010 SRI Annual Meeting in Orlando, Florida, two senior investigators will be discussing/judging posters presented by in training investigators . The Poster Presenter will summarize their work for the judges, followed by questions from the poster discussants/judges . Awards will be given to the best 20 posters at the Hot Pizza and Hot Topics and Awards Luncheon .

Underrepresented Minority Registration AwardsTo both encourage global participation and further diversify the Annual Meeting, SRI offers awards to allow discounted Annual Meeting registration for 25 individuals who are underrepresented in their country or originate from a low-income, lower-middle-income, or upper-middle-income country . The awardees will be recognized at the Annual Meeting .

All 2018 award recipients will be announced at the meeting.

2018 AWARDS


ABOUT SRI It started in 1953…when a small group of physician-scientists and a basic researcher studying hypertensive disorders of pregnancy proposed the formation of an “Eclampsia” or “Toxemia” society . Leaders of the group included Drs . Nicholas Assali, Leon Chesley, Edward Davis, William Dieckmann, Russel de Alverez, Louis Hellman, and Ernst Page . In Dr . Larry Longo’s book, A Short History of the Society for Gynecologic Investigation, he states that the “Society of University Gynecologists”, as it was first called, was organized “…to stimulate, encourage, and to provide opportunities for investigators in obstetrics and gynecology to enter into free exchange of ideas to the end of increasing knowledge and techniques in this field . It was intended primarily for individuals who are giving full or considerable time to teaching and research, either in obstetrics and gynecology or in the fields kindred or related thereto .”

The first official meeting of the Society of University Gynecologists was held on June 15, 1953, at the Yale Club in New York City . The first annual meeting took place in December of 1953 in Cincinnati, OH, with a programmatic focus on toxemias of pregnancy . During this time, the leadership contemplated whether the name of the society was truly representative of the overarching interests of the members . While the name was formally changed to “Society for Gynecologic Investigation” at the annual meeting in Chicago in 1954, the topic was re-visited over the years, and in the summer of 2013, as a part of an SGI Executive Council strategic planning discussion, the name of the Society was re-evaluated, and in 2014 it was changed to the current, “Society for Reproductive Investigation .”

The Society adopted its first journal in 1970, which was termed “Gynecological Investigation”, and became the society’s official publication, with Walter Hermann serving as Editor-in Chief . Publication was stopped shortly thereafter, in 1975 . All SGI proceedings were subsequently published by the American Journal of Obstetrics and Gynecology, with Dan Mishell as the SGI Editor . The SGI re-initiated its own journal in 1994, The Journal of the Society for Gynecologic Investigation, with Roger Lobo as its first Editor . In 2007 under Hugh Taylor’s leadership, the Society’s journal has morphed again to its current title, Reproductive Sciences .

From its initial roster of 15 members, the Society has grown in numbers and diversity, with 93 members in 1964 to nearly 300 members in 1978, and to the 2016 membership of almost 1,000 worldwide . One-third of the members are basic scientists and two-thirds are clinical investigators . SRI members conduct basic, translational and clinical investigation in the reproductive sciences and women’s health . Areas of focus include obstetrics, perinatology, reproductive genetics, gynecology, gynecologic oncology, reproductive endocrinology, reproductive physiology, biochemistry, pharmacology, immunology, epidemiology, reproductive infectious disease and reproductive stem cell and developmental biology . Many members hold esteemed government-level grants and serve on study sections and advisory councils for national agencies and private foundations .


Mission StatementThe mission of the Society for Reproductive Investigation (SRI) is to advance reproductive and women’s healthcare through outstanding basic, translational, and clinical science and by training and mentoring future generations of investigators .

MembershipRegular Membership may be conferred on those individuals who provide evidence of a doctorate degree (M .D ., Ph .D ., D .Pharm .) and evidence of at least two (2) years of research experience including, but not limited to, postdoctoral, basic science or clinical fellowship . While a minimum of two (2) years should have been spent in this research career, there is no requirement that the nominee should have worked at his/her current institution for two (2) years . Eligible individuals must be nominated . Upon election to membership the newly elected member and sponsoring member will be notified of the fact of his/her election .

Associate Membership is for individuals involved in research and/or health care in Obstetrics and Gynecology, Reproductive Medicine and Biology, or allied fields . This category includes laboratory managers, technologists, clinical research nurses and study coordinators, medical marketing and promotion, non-academic-based researchers, pharmaceutical/biotechnology representatives, among others .

Emeritus Membership Each member of the Society shall, upon reaching his/her sixty-fifth (65) birthday and working no more than 25 percent, provide a written statement in order to become eligible for “Emeritus” status . The member may elect to stay active for as long as he/she wishes . Once a member elects “emeritus status”, he/she shall be entitled to all the rights and privileges of the Society, but will not have to pay annual dues, will not be asked to vote, and will not be eligible to be a an elected officer .

Honorary Membership in the SRI is awarded to an individual who has achieved recognition for scientific contributions of an original nature in reproductive biology in which he/she has personally actively participated . This person should have demonstrated by past performance and future objectives that this interest in reproductive biology is dynamic . The individual need not necessarily occupy a position in an institution of higher learning, nor necessarily function in a medical or paramedical area . Honorary Members shall enjoy all of the rights and privileges of other members of the Society, except that they shall not be required to pay any dues or assessments, shall not be entitled to vote at any regular or special meetings of members, nor to hold any elective or appointive office in the Society .

In Training Membership is available for members who are not in a faculty position . They must be a full-time postdoctoral trainee, resident, fellow or student enrolled in a formal approved training program leading to a degree (B .A ., B .S ., M .D ., Ph .D ., M .S ., M .P .H ., and D .V .M .) . Candidates will be proposed by a member in good-standing of the Society . The In Training member will pay nominal dues sufficient to cover administrative costs, may participate in all activities of the Society and subscribe to the Society’s journal if desired but may not sponsor abstracts or vote . This status expires when the member completes training at which time application for regular membership is expected .

ABOUT SRI


SRI COUNCIL & STAFF 2017 – 2018 CouncilPresident Sandra T. Davidge, PhDUniversity of Alberta

Immediate Past PresidentYoel Sadovsky, MDMagee-Women’s Research Institute

President-ElectMurray D. Mitchell, DPhil, DSc University of Queensland

President NomineeJames H. Segars, MDJohns Hopkins University School of Medicine

Secretary TreasurerIan M. Bird, PhD (2020)University of Wisconsin-Madison

Council MembersPhillip R. Bennett, MD, PhD (2019)Imperial College London

Elizabeth Ann Bonney, MD, MPH (2019)University of Vermont

Stephen Matthews, PhD (2020)University of Toronto

Sam Mesiano, PhD (2020)NorthShore University Health System

Errol R. Norwitz, MD, PhD (2018)Tufts University

Stacy Zamudio, PhD (2018)Hackensack University MC

In Training Ad Hoc Council MemberFloor Spaans, PhDUniversity of Alberta

StaffAnne Krolikowski, CAEExecutive Director(akrolikowski@sri-online .org)

Leah MillerAssociate Executive Director(lmiller@sri-online .org)

Debra Hangsterfer Fundraising Manager(dhangsterfer@sri-online .org)

Michelle HolmMeetings Manager(mholm@sri-online .org)

Morgan DerbyMembership and Communications Manager(mderby@sri-online .org)

106 SOCIETY FOR REPRODUCTIVE INVESTIGATION 65th Annual Scientific Meeting106 SOCIETY FOR REPRODUCTIVE INVESTIGATION 65th Annual Scientific Meeting

ORAL AND POSTER ABSTRACT AUTHOR INDEX

Author Index

Plenary/Oral Sessions Abstract Numbers Program Pages

Thursday, March 8, 2018, 9:00 AM-10:00 AMPresident’s New Investigator Plenary O-001 – O-004 18 – 19

Thursday, March 8, 2018, 1:30 PM-3:30 PM

Clinical and Translational Perinatology I O-005 – O-012 19 – 20 Gynecology I O-013 – O-020 21 – 22Parturition I O-021 – O-028 22 – 23 Placenta I O-029 – O-036 23 – 24 Preeclampsia I O-037 – O-044 24 – 26 Reproductive Biology I O-045 – O-052 26 – 27

Friday, March 9, 2018, 11:00 AM-12:30 PM

Developmental Programming I O-053 – O-058 32 – 33 Fetus I O-059 – O-064 33 – 34 Gynecology II O-065 – O-070 35 Maternal Biology and Health O-071 – O-076 36 Parturition II O-077 – O-082 37 Reproductive Endocrinology and Infertility I O-083 – O-088 38 – 39 Friday, March 9, 2018, 4:30 PM-6:00 PM

Epidemiology and Global Health O-089 – O-094 43 – 44 Fetus II O-095 – O-100 44 – 45 Gynecologic Oncology O-101 – O-106 45 – 46

Gynecology III O-107 – O-112 46 – 47

Preeclampsia II O-113 – O-118 47 – 48

Reproductive Biology II O-119 – O-124 48 – 49

Saturday, March 10, 2018, 11:30 AM-1:00 PMClinical and Translational Perinatology II O-125 – O-130 51 – 52

Developmental Programming II O-131 – O-136 52 – 53 Parturition III O-137 – O-142 53 – 54 Placenta II O-143 – O-148 54 – 55 Regenerative Medicine O-149 – O-154 55 – 56 Reproductive Endocrinology and Infertility II O-155 – O-160 56 – 57

MARCH 6 - 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 107MARCH 6 - 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 107


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Poster Sessions Abstract Numbers Program Pages

Thursday, March 8, 2018, 10:00 AM-12:00 PMBasic Parturition, Prematurity T-001 – T-028 59 – 60 Clinical Perinatology T-029 – T-061 60 – 62 Developmental Programming T-062 – T-076 62 – 63 Epidemiology T-077 – T-079 63 Fetus T-080 – T-095 63 – 64 Global Health T-096 – T-097 64Gynecologic Oncology T-098 – T-102 64 Gynecology T-103 – T-121 64 – 65 Maternal Biology, Health T-122 – T-133 65 – 66 Placenta T-134 – T-164 66 – 68Population Health T-165 – T-167 68Preeclampsia, Related Disorders T-168 – T-193 68 – 69Reproductive Biology T-194 – T-206 69 – 70Reproductive Endocrinology, Infertility T-207 – T-220 70 – 71

Friday, March 9, 2018, 9:00 AM-11:00 AMBasic Parturition, Prematurity F-001 – F-028 72 – 73Clinical Perinatology F-029 – F-061 73 – 75Developmental Programming F-062 – F-076 75 – 76Epidemiology F-077 – F-079 76Fetus F-080 – F-095 76 – 77Global Health F-096 77Gynecologic Oncology F-097 – F-101 77Gynecology F-102 – F-121 77 – 78Maternal Biology, Health F-122 – F-132 78 – 79Placenta F-133 – F-163 79 – 80Population Health F-164 – F-166 80 – 81Preeclampsia, Related Disorders F-167 – F-193 81 – 82Reproductive Biology F-194 – F-208 82 – 83Reproductive Endocrinology, Infertility F-209 – F-221 83 – 84



Author Index

Poster Sessions Abstract Numbers Program Pages

Saturday, March 10, 2018, 9:30 AM-11:30 AM

Basic Parturition, Prematurity S-001 – S-028 85 – 86Clinical Perinatology S-029 – S-060 86 – 88Developmental Programming S-061 – S-077 88 – 89Epidemiology S-078 – S-080 89Fetus S-081 – S-096A 89 – 90Global Health S-097 90Gynecologic Oncology S-098 – S-102 90Gynecology S-103 – S-122 90 – 91Maternal Biology, Health S-123 – S-133 91 – 92Placenta S-134 – S-164 92 – 94Population Health S-165 – S-167 94Preeclampsia, Related Disorders S-168 – S-193 94 – 95Reproductive Biology S-194 – S-208 95 – 96

Reproductive Endocrinology, Infertility S-209 – S-221 96 – 97



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SRI THANKS OUR 2018 SUPPORTERS

AbbVie Inc.

Bayer AG

Burroughs Wellcome Fund

Cook Medical

Ferring Pharmaceuticals Inc.

Fondazione Giorgio Pardi

Pfizer Inc.

Ramya Narayanan, M.D.

Society for Reproductive Investigation

66th Annual Scientific MeetingMarch 12 - 16, 2019 · Palasis des Congrès de Paris

P A R I S , F R A N C E

— S AV E T H E D A T E —

SRI-0917-242

Documents

65 SRI AM/am18... · MARCH 6 - 10, 2018 HILTON SAN DIEGO BAYFRONT, SAN DIEGO, CA 1 MESSAGE FROM THE SRI PRESIDENT Dear Colleagues: Welcome to the 65th Annual Scientific Meeting of