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Jajah Fachiroh , Rina Susilowati
Basic Course on immunology
Yogyakarta, 23 - 25 April 2012
Mucosal Immune System
Deparment of Histology and Cell BiologyFaculty of Medicine
Universitas Gadjah Mada
[email protected]
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CONTENTS
1. Introduction
2. Anatomic feature
3. Effector mechanism
4. Immunoregulatory environment
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IntroductionThe importance of mucosal immunity
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4
Mucosal surface exposed continuously to large amount of
pathogens
Enormous area to be protected
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5
Mucosal infections are one of the biggest health problems
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6
Primary lymphoid
organs
Secondary lymphoid
organs
NALT
ring
BALT
GALT
Lymphoid tissue of urogenitaltract
Mucosa-associated Lymphoid Tissue
(MALT)
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Anatomic featureEmphasizes on GALT
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David Artis, 2008 Nature Reviews Immunology 8, 411-420
(a) microvillar extension
(b) epithelial-cell tight
junctions
(c) apically attached and
secreted mucins that form a
glycocalyx
(d) production of various
antimicrobial peptides
(e) M (microfold) cells overlie
Peyer's patches (f) to promote
uptake and transport of
luminal contents to
professional APC
(g).dendritic cell (DC) can also
extend dendrites between the
tight junctions of intestinal
epithelial cells to sample
luminal contents
Epithelium provides host direct protection from luminal
microbes
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In the gut, Mucosa-associated Lymphoid Tissue is located in
anatomically defines compartments
Anatomic feature of mucosal immune system
Johannes Conrad Peyer
(1653 1712), a Swiss anatomist
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Lamina propria
MALT
Effector site
Inductive site
Anatomic feature of mucosal immune system
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11
GALT
Jejenum Ileum
Anatomic feature of mucosal immune system
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12
Substances & microorganism
taken up by M cells
Anatomic feature of mucosal immune system
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13
The organization of the mucosal immune system
GALT
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The organization of the mucosal immune system: dendritic
cells
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Effector mechanismImmune response in GALT
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Homing receptor determines the effector site
Lamina propria
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The circulation of lymphocytes within the mucosal immune system
is controlled by tissue-specific adhesion molecules and chemokine
receptors
Homing receptor determines effector site
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Iwasaki, Annu. Rev. Immunol. 2007. 25:381 418
Molecular control of intestine specific
homing of lymphocytes
Homing receptor determines effector site
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The mucosal immune system contains large numbers of effector
lymphocytes even in
the absence of disease
Homing receptor determines effector site
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20
Epithelial cells
T cells
B cells
Intraepithelial lymphocytes
(IEL) type a & b
Efector cells in GALT : Intra epithelial lymphocytes
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21
Intraepithelial lymphocytes type a (classical CD8 CTL;
heterodimer) recognize virus infected epithelial cells
Efector cells in GALT : Intra epithelial lymphocytes
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Intraepithelial lymphocytes type b (non classical CD8
homodimer) recognize stress epithelial cells
Efector cells in GALT : Intra epithelial lymphocytes
