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Pharmacokinetics

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Servier Medical Art by Servier is licensed under a Creative Commons Attribution 3.0 Unported License

Oral administration

Blood concentration afteroral administration

Blood concentration afterrepeated oral administration

Time

Con

cent

ratio

n

Cmax

tmax

TimeC

once

ntra

tion

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IV administration

Blood concentrationduring a perfusion

Blood concentration duringa repeated intravenously

administration

TimeC

once

ntra

tion

Time

Con

cent

ratio

n

Accumulationphase

Equilibriumphase

Decreasephase

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Pluriexponential decreaseof plasmatic concentration

Time

Con

cent

ratio

n

TimeC

once

ntra

tion

Exponential decrease ofplasmatic concentraion

C0

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Dose/effect link

Normal people

Plasmatic concentration

Eff

ect

inte

nsity

Therapeutic effectSide effects

Time

Con

cent

ratio

n

Time

Con

cent

ratio

n

People suffering fromrenal insufficiency

Emax

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Blood concentration with and without enterohepatic recycling

Time

Con

cent

ratio

nWith enterohepaticrecycling

Without enterohepaticrecycling

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Gauss curve