Change in Additional Lung Function Variables

Following a Single Bout of Exercise. *Significant change after exercise.

Significant Improvement in Spirometric Variables

Following a Single Bout of Exercise

*Significant change after exercise

These data support that one session of maximal exercise can significantly

improve lung function in patients with CF. In addition, higher peak work

rates and ventilation during exercise both predict a greater improvement in

post exercise lung function. Future studies are warranted to determine the

most effective dose of exercise to improve lung function in CF.

Patients with Cystic Fibrosis (CF) typically have a progressive decrease in

lung function over time.

Exercise capacity has been shown to predict mortality in CF, independent

of lung function

Evidence suggests that chronic participation in an aerobic exercise

program can improve lung function in the CF population.

A Single Maximal Exercise Test improves Lung Function in Patients with

Cystic FibrosisReva H Crandall1,2, Nichole Seigler2, Paula Rodriguez-Miguelez2, Katie T McKie3,

Caralee Forseen4, Ryan A Harris2,5

1Georgia Regents University, Respiratory Care, Augusta GA 2Georgia Regents University, Georgia Prevention Institute, Augusta GA 3Georgia Regents University, Pediatric Pulmonology, Augusta GA 4Georgia Regents University, Pulmonary and Critical Care Medicine, Augusta GA

5University of Ulster, Sport and Exercise Research Institute, Jordanstown, Northern Ireland, UK

Laboratory of Integrative

Vascular & Exercise Physiology

This project was supported in part

by NIH/NIDDK R21DK100783 and

Vertex Pharmaceuticals IIS (RAH).

Table 1. Subject Characteristics

Figure 1: Forced vital capacity Figure 2: Forced expiratory volume

in one second (% predicted)

Figure 3: Forced expiratory

flow at 25-75%

Figure 4. Forced expiratory volume

in one second (L/s)

Introduction

Purpose

Methods

Results

Conclusion

Variable Baseline

N 26

Age (yrs) 19.6 ± 1.6

Sex (M,F) 10,16

Median FEV1 % predicted 81

BMI (kg/m2) 21.1 ± 0.7

Body Fat (%) 25.9 ± 1.6

Systolic Blood Pressure (mm Hg) 108 ± 2

Diastolic Blood Pressure (mm Hg) 63 ± 1

O2 Saturation (%) 97.6 ± 0.3

Fat Free Mass (kg) 39.0 ± 2.3

Exercise Intensity Predicts Change in Post-Exercise

Lung Function

Figure 5. Diffusing capacity for carbon

monoxide

Acknowledgements

Table 2. Exercise Data

Values are mean ± SEM. Values are mean ± SEM.

Subjects: Twenty-six patients with CF (16 females and 10 males, ages 9-43

years old) participated in this study. Patients performed lung function testing

at baseline and again 10 minutes following maximal cardio-pulmonary

exercise testing (CPET) using the Godfrey protocol, on a cycle ergometer.

The purpose of this study was to determine if one session of maximal exercise

can improve lung function in patients with CF.

Pulmonary Function Test: Spirometric variables

measured were forced vital capacity (FVC), forced

expiratory volume in one second (FEV1), and

forced expiratory flow 25-75% (FEF 25-75%), using the

EasyOne Pro® Spirometry System. Additional lung

function parameters included assessment of lung

clearance index (LCI), single breath carbon

monoxide diffusion capacity (DLCOSB), exhaled

Maximal Exercise Capacity Test: Following an

overnight fast, patients performed a maximal exercise test

on a cycle ergometer using the Godfrey protocol. After 2

minutes of rest and 2 minutes of an unloaded warm-up,

exercise intensity was increased either 15 or 20 watts

every minute depending on the patient’s height. Expired

gases were collected breath by breath, and maximal

exercise capacity data was calculated using 30-second

averages.

nitric oxide (eNO), and impulse oscillimetry (IOS). Pulmonary function test

was performed on all subjects according to standards set by the American

Thoracic Society.

Data Analysis: Data are presented as mean ± SD. Paired t-tests were

performed to identify differences between pre and post exercise. Pearson

correlations were determined to identify associations between change in lung

function and exercise variables. Significance was set at p-value < 0.05.

Figure 6. Lung clearance index

Figure 8. Exhaled nitric oxideFigure 7. Vital capacity

Variable Max CPET

VO2 peak (L/min) 1.7 ± 0.1

VO2 peak (ml/kg/min) 30.1 ± 1.1

VO2 (% predicted) 75.9 ± 3.1

Peak Work (W) 139 ± 8

% VO2 peak @ AT 61.3 ± 2.0

VE (L/min) 70.7 ± 5.3

Resting Heart Rate (bpm) 72 ± 3

Max Heart Rate (bpm) 173 ± 3

Resting RER 0.88 ± 0.04

Max RER 1.24 ± 0.03

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