A Walk Around the Intuvo

Simon JonesGC Application Scientist

February 13, 2019

February 13, 20191

• Easier

• Faster

• Smaller

• Smarter

• Greener

2

Innovating a New Path to GC Productivity

A whole new way to GC

3

Direct

heating

Innovating a New Path to GC Productivity

A whole new way to GC

4

No-trim

column

Direct

heating

Innovating a New Path to GC Productivity

A whole new way to GC

Innovating a New Path to GC Productivity

A whole new way to GC

5

No-trim

column

Direct

heating

Ferrule-free click-and-run

connections

6

Disposable

Intuvo

Guard Chip

No-trim

column

Direct

heating

Ferrule-free click-and-run

connections

Innovating a New Path to GC Productivity

A whole new way to GC

7

Disposable

Intuvo

Guard Chip

No-trim

column

Direct

heating

Modular

Intuvo Flow Chips

Ferrule-free click-and-run

connections

Innovating a New Path to GC Productivity

A whole new way to GC

A New Portfolio of GC Consumables

UI inlet linersGuard Chip

No-trim

column

Flow

Chips

Smart keys

Tools and

accessories

Intuvo Smart KeysSelf aware

• Flow Chips and columns

• Smart: informs how Intuvo is configured

• Easy: sets method context and parameter defaults – no complex calculators needed

9

Flexible Compatible DesignConfigurable to many applications

• SSL, MMI, GSV, LSV inlets

• FID, TCD, ECD, NPD, FPD, NCD, SCD detectors

• SQ and TQ mass spectrometers

• Headspace, thermal desorption, purge and trap samplers

• 16-, 50-, 150-position autoinjectors and trays

• Software: Agilent OpenLab and MassHunter

10

Comparing the Agilent 7890 GC with the Intuvo 9000 GC

7890 Intuvo

Footprint (H × W × D) in

Inches

19.2 × 22.9 × 20.2 20 × 10.7 × 27.2

Power Consumption 2,250 VA standard (2,950 VA /220) 1,296 VA standard (1,548 VA / 220)

Oven Ramp Rate Temperature

Range (°C)

120 V

Oven

Fast Oven Fast oven

with Pillow Maximum achievable temperature

ramp rate: 250 °C/min50 to 70 75 120 120

70 to 115 45 95 120

115 to 175 40 65 110

175 to 300 30 45 80

300 to 450 20 35 65

Oven Cooling Rate

Oven cool down (22 °C ambient) 450 to 50

°C in 4 minutes (3.5 minutes with oven

insert accessory)

Oven cool down (22 °C ambient)

450 to 50 °C in less than 3 minutes

Heat Dissipation

Standard oven ramp

7,681 BTU / hour

maximum 120 V

4,424 BTU /

hour maximum

Fast oven ramp 10,071 BTU / hour

maximum 200 to 240 V 5,285 BTU /

hour maximum

11

Smaller Footprint

12

10.7” 22.9”

New Heated Zones

13

Guard Chip

Bus

Intuvo with MSD, FID, and Postcolumn Backflush

14

Mini-Bus

What ‘Can’ it Do?

One inlet (SSL or MMI)

Two detectors

can split 1:1 between detectors – including MSD

Column limitation of 60 m total, max ID of 0.32 mm

Midcolumn backflush

Postcolumn backflush

15

Innovating the GC Flowpath

16

To detector

Conventional

flowpath

Inlet

Gold seal

Nuts and ferrules

Classic capillary

column

Innovating the GC Flowpath

17

To detector

Conventional

flowpath

Intuvo

flowpath

Inlet Inlet

Guard Chip

Gold seal

Nuts and ferrules

Classic capillary

column

Innovating the GC Flowpath

18

Click-and-run

direct

connections

To detector

To detector

Conventional

flowpath

Intuvo

flowpath

Inlet Inlet

Guard Chip

Intuvo planar

column

Gold seal

Nuts and ferrules

Classic capillary

column

Flow

Chip

Modular Intuvo Flow ChipsHigh-purity inert silica flowpath

• Inert

• Modular, configurable

• Click-and-run connections

19

Intuvo Flow Chip

cross section

Thermally conductive

proprietary alloy

High-purity

silica channel

Intuvo Ultra Inert

treatment

Carrier

gas

Guard/Jumper Chips

20

Roughly 0.75 m × 0.53 mm ID

Click-and-Run Direct ConnectionsEliminating connection uncertainty

• No more ferrules

• Direct face seal connections

• Audible and tactile click lets you know connection is made

• Easier to train

• Less unplanned downtime

• Fewer batch reruns and precious samples lost

22

Intuvo Flow Chips – Installation Distance Always Perfect

No more:

- measuring

- overtightening

- trimming

Intuvo Inert FlowpathOptimized for active compounds

25

5 ppb injection of pesticide mix

TQ MRM transitionsChrysene-d12

EPN

Pyroclostrobin

Perylene-d12

Phosalone

Coumaphos

Agilent 7000 triple

quadrupole GC/MS

Intuvo Graphical User Interface

• System status

26

Intuvo Graphical User Interface

• System status

• Real time chromatograms

27

min.0.6 0.8 1.0 1.2 1.4 1.6 1.8

pA

0

500

1000

1500

2000

2500

3000

Intuvo Graphical User Interface

• System status

• Real time chromatograms

• Finding parts fast

28

ReplaceInletLiner

FindInletParts

InletLinerPartNumber8001-

0101

Intuvo Graphical User Interface

• System status

• Real time chromatograms

• Finding parts fast

• Step-by-step user maintenance and troubleshooting

29

Autonomous Leak CheckingAvoiding unplanned downtime

Microfluidic-enabled sixth generation EPC modules allow hands-free leak checking to confirm and document leak-free operation autonomously.

30

Intuvo Graphical User InterfaceInteractive maintenance

31

Remove lock nut and septum

Replace liner

Step 1: Remove lock nut

Maintenance?!

32

You lose the screen as

soon as you open the

door to do the

maintenance!

Remote Access to Intuvo Screen

Access the Onscreen Tools Remotely

Counters Give you Quick System Information

35

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance

Column Maintenance – Automatic Leak Checks!

Column Maintenance – Automatic Leak Checks!

Column Installation

47

It is much easier to

install the column, but

there are still some

‘Gotchas’!

Tips to Ensure a Good Column Installation

1. Finger tighten until only one thread on each of the two nuts is showing.

If more than one thread is showing, wiggle or reposition the column into place to further finger-tighten the nuts to one thread.

Tips to Ensure a Good Column Installation

2. Check that the small integrated column nuts on the column are in form-fitted place on the heater in the instrument.

3. Click and run!

Intuvo Guard Chip and No-Trim ColumnsNo retention time shifts after maintenance

50

0.5 min

Shifts beyond

retention time

window

Pesticide mix injected before and

after 300 mm column trim

0.5 min

Maintaining

retention times

Pesticide mix injected before and

after Guard Chip change

Conventional Column Intuvo Column

February 13, 2019 Title Confidentiality label Regulatory statement (if applicable)51

6x10

0

0.2

0.4

0.6

0.8

1

1.2

1.4

1.6

1.8

2

2.2

2.4

2.6

2.8

3

3.2

3.4

3.6

Counts vs. Acquisition Time (min)

27 27.5 28 28.5 29 29.5 30 30.5 31 31.5 32 32.5 33 33.5 34 34.5 35 35.5 36 36.5 37 37.5

1

81

4

1

31

0

1

7

1

1

1

2

1

5 1

6

4x10

00.20.40.60.8

11.21.41.61.8

22.22.42.62.8

33.23.43.63.8

44.24.44.64.8

5

Counts vs. Acquisition Time (min)26.5 27 27.5 28 28.5 29 29.5 30 30.5 31 31.5 32 32.5 33 33.5 34 34.5 35 35.5 36 36.5 37 37.5

1

8

1

7

1

51

6

1

41

31

0

1

1

1

2

7890

Intuvo

Guard Chip Versus Column Trimming

1x10

-0.1

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1

1.1

1.2

1.3

1.4

1.5

1.6

1.7

1.8

1.9

2

2.1

2.2

2.3

2.4

2.5

2.6

2.7

2.8

2.9

3

3.1

3.2

3.3

3.4

3.5

3.6

3.7

3.8

3.9

4

4.1

4.2

4.3

4.4

4.5

4.6

4.7

4.8

4.9

5

5.1

5.2

5.3

5.4

5.5

5.6

+ TIC Scan 12 Cal-10 (Dec 10) 20000 ppb .D

Counts (%) vs. Acquisition Time (min)

4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5 18 18.5 19 19.5 20 20.5 21 21.5 22 22.5 23 23.5 24

1x10

0

0.1

0.2

0.3

0.4

0.5

0.6

0.7

0.8

0.9

1

1.1

1.2

1.3

1.4

1.5

1.6

1.7

1.8

1.9

2

2.1

2.2

2.3

2.4

2.5

2.6

2.7

2.8

2.9

3

3.1

3.2

3.3

3.4

3.5

3.6

3.7

+ TIC Scan 12 CAL 10 (20000 ppb) - Apr 30.d

Counts (%) vs. Acquisition Time (min)

4 4.5 5 5.5 6 6.5 7 7.5 8 8.5 9 9.5 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5 18 18.5 19 19.5 20 20.5 21 21.5 22 22.5 23 23.5 24

Seamless Method Migration to IntuvoNo business disruption

52

Intuvo

7890

83 SVOC by US EPA 8270

February 13, 2019 Title Confidentiality label Regulatory statement (if applicable)53

7890 GC

Intuvo GC

42

Acquisition Time (min)3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66

1 35 6

7

9

8

10

12

11

13

1814

15, 16, 17

21

19

20

22 2523 24

PAHs

How Does it Line Up?

Fast Direct Heating and CoolingEvery single minute counts

• Fast, efficient heating

• Ballistic cooling

• Smaller footprint

“We are the police – we need answers fast. Even a 1 minute faster cool-down

would be valuable…”

54

Ultra Fast GCIt’s all about how well you do GC, fast

55

min0 0.5 1 1.5 2 2.5

pA

0

500

1000

1500

2000

2500

3000

C5

C6

C7C8 C9

C10

C11

C12

C14

C15

C16

C17

C18

C20 C24 C28 C32 C36 C40 C44

Five replicate overlay of ASTM D7798 SimDist standard mix

Recovery

C5 0.9

C6 0.9

C7 1.0

C8 1.0

C9 1.0

C10 1.0

C11 1.0

C12 1.0

C14 1.0

C15 1.0

C16 1.0

C17 1.0

C18 1.0

C20 1.0

C24 1.0

C28 1.0

C32 1.0

C36 1.0

C40 1.0

C44 0.9

• Excellent retention time and

area count reproducibility

• No concern for cold spots

Efficient, Even, Direct Heating

56

0.00

0.50

1.00

1.50

2.00

2.50

0 10 20 30 40 50 60 70 80

Rela

tive

Resp

on

se

Compound Number

7890Intuvo

Benzo[b]fluouranthene

Benzo[k]fluoranthene

Benzo[a]pyrene

Perylene-d12(ISTD)

Indeno[1,2,3-cd]pyrene

Dibenz[a,h]anthracene

Benzo[ghi]perylene

0

20

40

60

80

100

120

17 18 19 20 21 22 23

PAHs0.098ug/mL9000/5977A(scan)

High molecular

weight PAH

compounds also

have largely identical

response factors

Even high molecular

weight compounds such

as Benzo(ghi)perylene

(molecular weight 276

amu) have excellent

peak shape

Optimizing Lab SpaceSupporting lean laboratory thinking

Less than half:

• Power consumption

• Heat output into laboratory

• Laboratory bench footprint

• Lower operating costs

• Higher efficiency

• Greener

57

Accessing the Power of InnovationTransforming the user experience

New mobilized generation

• Expectations of remote mobile connection

• Technology accessed through interactive graphic SW and apps

Make technology accessible

• Interface meeting today’s expectations

58

Internet of ThingsA full suite of customer support

• Intuvo serves up a web homepage

• User help for maintenance, troubleshooting, and diagnostics

• Accessible through any approved PC or mobile device securely on internal network

59

Keep ConnectedTablet or phone connectivity

60

Go Mobile

Check instrument and batch

status remotely

Confirm laboratory operations

while out of the laboratory

Connect to any instrument with

a single mobile device

A Gateway of Information at Your FingertipsWhenever and wherever you are

• Online resources

• Agilent University

• YouTube

• Agilent.com

• Agilent GC community

61

Agilent CrossLab Services for IntuvoA streamlined service experience

Intuvo 9000 GC Health Report

Installation and familiarization

Compliance services

Education

62

An Ideal Partner for Mass Spectrometry

• Guard Chip protection of column and MS ion source

• Retention time stability after changing Guard Chip

• Easy and reliable backflush

• Leak-free click-and-run connections

• Fast direct heating and cooling

63

Intuvo 9000 GC Videos

The Agilent Intuvo 9000 GC System – Environmental Science Corporation (ESC)

Discover higher GC productivity with the Agilent Intuvo 9000 GC system.

Playing Time: 4:00

The Agilent Intuvo 9000 GC System Story

Learn more about the Agilent Intuvo 9000 GC System

Playing Time: 2:21

The Agilent Intuvo 9000 GC System: Return on Investment. Return on Innovation

A testimonial regarding the return on investment on the Agilent Intuvo 9000 GC System

Playing Time: 4:17

August 2016 AGILENT CONFIDENTIAL65

Questions

66

Contact Agilent Chemistries and Supplies Technical Support

1-800-227-9770 Option 3, Option 3:

• Option 1 for GC/GCMS Columns and Supplies

• Option 2 for LC/LCMS Columns and Supplies

• Option 3 for Sample Preparation, Filtration, and QuEChERS

• Option 4 for Spectroscopy Supplies

• gc-column-support@agilent.com

• lc-column-support@agilent.com

• spp-support@agilent.com

• spectro-supplies-support@agilent.com