Volume 12 Number 4 April, 1985 Papillary adenoma of nipple 715 benign lesion simulating carcinoma clinicaUy and patho- logically. Am J Surg 119:322-325, 1970, 11. Doctor VM, Sirsat MV: Floridpapillomatosis (adenoma) and other benign turnouts of the nipple and areola. Br J Cancer 25: I-9, 1971. 12. Richards AT, Jaffe A, Hunt JA: Adenoma of the nipple in a male. S Afr Med J 47:581-583, 1973. 13. Waldo ED, Sidhu GS, Hu AW: Florid papillomatosis of male nipple after diethylstilbestrol therapy. Arch Pathol 99:364-366, 1975. 14. Smith EJ, Kron SD, Gross PR: Erosive adenomatosis of the nipple. Arch Dermatol 102:330-332, 1970. 15. Lewis HM, Ovitz ML, Golitz LE: Erosive adenomatosis of the nipple. Arch Dermatol 112:1427-1428, 1976. 16. Smith NP, Wilson Jones E: Erosive adenomatosis of the nipple. Clin Exp Dermatol 2:79-84, 1977. 17. Rosen PP: Syringomatous adenoma of the nipple, Am 3 Surg Pathol 7:739-745, 1983. 18. Sneddon IB: Hidradenoma of the nipple. Br J Dermatol 78:611, 1966. 19. Tappeiner J, Wolff K: Hidradenoma papilliferum. Eine enzymhistochemische und elektronenmikroskopische Studie. Hautarzt 19:101-109, 1968. ABSTRACTS Spontaneous cholecystocutaneous fistula Abril A, Ulfohn A: South Med J 77:1192-1193, 1984 Another fistula in skin is this one opening in a well-healed surgical scar in the right upper quadrant of the abdomen, It linked the skin to the gall bladder. These often resemble squamous ceil carcinomas and fool the unwary. P.C.A. Sex related survival differences in instances of melanoma Reintgen DS, Paull DE, Seigler HF, et al: Surg Gynecol Obstet 159:367-372, 1984 This interesting review of 1,489 melanomas explores the oft-noted observation that women survive melanoma better than do men. P.C.A. Pimozide approved for Tourette's syndrome. FDA Drug Bull 14:24-25, 1984 The Food and Drug Administration has approved pimozide (Orap), a neuroleptic drug, for the treatment of Tourette's syndrome in patients who cannot tolerate or do not respond to haloperidol. Pimozide prolongs the electrocardiogram (ECG) Q-T interval and is contraindicated in patients with congenital long Q-T syndrome, cardiac arrhythmia, and with drugs prolonging the Q-T interval. The label states that a dose of 0.3 mg/kg/day or 20 mg/day should not be exceeded. ECGs should be performed prior to administration of pimozide and periodically thereafter. In mice the drug produces a dose-related increase in pituitary tumors. Patients chronically exposed to pimozide can be expected to develop tardive dys- kinesia. Experience with patients under the age of 12 years is extremely limited. J.G.S. Multistage skin carcinogenesis: A useful model for the study of the chemoprevention of cancer Slaga TJ: Acta Pharmacol Toxicol (Copenh) 55(suppl 2):107-124, 1984 Carcinogenesis in humans is a subject of major political interest. All parties are seeking chemoprevention of cancer. This article from the University of Texas system discusses the utility of skin cancer as a model to study the general problem. Various inducers, or initiators, pzomoters, or en- hancers of cancer of the skin are discussed. The comparatively simple three-stage model is explained. P.C.A. Allergic contact dermatitis secondary to transdermal nitroglycerin Rosenfeld AS, White WB: Am Heart J 108:1061- 1062, 1984 Apparently, most every medication by any route can sen- sitize someone. P.C.A. Radioisotopic studies concerning the efficacy of standard washing procedures for the cleansing of hair before zinc analysis Buckley RA, Dreosti IE: Am J Clin Nutr 40:840- 846, 1984 Studies of the composition of hair are notorious and must be evaluated very carefully. In a manner suggesting ion ex- change, zinc was absorbed from solutions into hair, according to these studies. The authors explore the utility of hair samples as a means of estimating "nutritional zinc status" and con- elude that such studies are "inadvisable." P.C.A.

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Volume 12 Number 4 April, 1985

Papillary adenoma o f nipple 715

benign lesion simulating carcinoma clinicaUy and patho- logically. Am J Surg 119:322-325, 1970,

11. Doctor VM, Sirsat MV: Floridpapillomatosis (adenoma) and other benign turnouts of the nipple and areola. Br J Cancer 25: I-9, 1971.

12. Richards AT, Jaffe A, Hunt JA: Adenoma of the nipple in a male. S Afr Med J 47:581-583, 1973.

13. Waldo ED, Sidhu GS, Hu AW: Florid papillomatosis of male nipple after diethylstilbestrol therapy. Arch Pathol 99:364-366, 1975.

14. Smith EJ, Kron SD, Gross PR: Erosive adenomatosis of the nipple. Arch Dermatol 102:330-332, 1970.

15. Lewis HM, Ovitz ML, Golitz LE: Erosive adenomatosis of the nipple. Arch Dermatol 112:1427-1428, 1976.

16. Smith NP, Wilson Jones E: Erosive adenomatosis of the nipple. Clin Exp Dermatol 2:79-84, 1977.

17. Rosen PP: Syringomatous adenoma of the nipple, Am 3 Surg Pathol 7:739-745, 1983.

18. Sneddon IB: Hidradenoma of the nipple. Br J Dermatol 78:611, 1966.

19. Tappeiner J, Wolff K: Hidradenoma papilliferum. Eine enzymhistochemische und elektronenmikroskopische Studie. Hautarzt 19:101-109, 1968.

ABSTRACTS

Spontaneous cholecystocutaneous fistula

Abril A, Ulfohn A: South Med J 77:1192-1193, 1984

Another fistula in skin is this one opening in a well-healed surgical scar in the right upper quadrant of the abdomen, It linked the skin to the gall bladder. These often resemble squamous ceil carcinomas and fool the unwary.

P.C.A.

Sex related survival differences in instances of melanoma

Reintgen DS, Paull DE, Seigler HF, et al: Surg Gynecol Obstet 159:367-372, 1984

This interesting review of 1,489 melanomas explores the oft-noted observation that women survive melanoma better than do men.

P.C.A.

Pimozide approved for Tourette's syndrome.

FDA Drug Bull 14:24-25, 1984

The Food and Drug Administration has approved pimozide (Orap), a neuroleptic drug, for the treatment of Tourette's syndrome in patients who cannot tolerate or do not respond to haloperidol. Pimozide prolongs the electrocardiogram (ECG) Q-T interval and is contraindicated in patients with congenital long Q-T syndrome, cardiac arrhythmia, and with drugs prolonging the Q-T interval. The label states that a dose of 0.3 mg/kg/day or 20 mg/day should not be exceeded. ECGs should be performed prior to administration of pimozide and periodically thereafter. In mice the drug produces a dose-related increase in pituitary tumors. Patients chronically exposed to pimozide can be expected to develop tardive dys- kinesia. Experience with patients under the age of 12 years is extremely limited.

J.G.S.

Multistage skin carcinogenesis: A useful model for the study of the chemoprevention of cancer

Slaga TJ: Acta Pharmacol Toxicol (Copenh) 55(suppl 2):107-124, 1984

Carcinogenesis in humans is a subject of major political interest. All parties are seeking chemoprevention of cancer. This article from the University of Texas system discusses the utility of skin cancer as a model to study the general problem. Various inducers, or initiators, pzomoters, or en- hancers of cancer of the skin are discussed. The comparatively simple three-stage model is explained.

P.C.A.

Allergic contact dermatitis secondary to transdermal nitroglycerin

Rosenfeld AS, White WB: Am Heart J 108:1061- 1062, 1984

Apparently, most every medication by any route can sen- sitize someone.

P.C.A.

Radioisotopic studies concerning the efficacy of standard washing procedures for the cleansing of hair before zinc analysis

Buckley RA, Dreosti IE: Am J Clin Nutr 40:840- 846, 1984

Studies of the composition of hair are notorious and must be evaluated very carefully. In a manner suggesting ion ex- change, zinc was absorbed from solutions into hair, according to these studies. The authors explore the utility of hair samples as a means of estimating "nutritional zinc status" and con- elude that such studies are "inadvisable."

P.C.A.