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Acetaminophen. 10–20% opioid-sparing effect 1 Synergistic with oral opioids 2 Additive effect greater than NSAIDs alone 3 IV preparation: Quick onset 4 Good side-effect profile; RID: 1–2%. 1. Remy, Br J Anaesth 2005;94:505–13 2. Chandrasekharan, Proc Natl Acad Sci 2002;99:13926–31 - PowerPoint PPT Presentation
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Acetaminophen
• 10–20% opioid-sparing effect1
• Synergistic with oral opioids2
• Additive effect greater than NSAIDs alone3
• IV preparation: Quick onset4
• Good side-effect profile; RID: 1–2%
1. Remy, Br J Anaesth 2005;94:505–13
2. Chandrasekharan, Proc Natl Acad Sci 2002;99:13926–31
3. Ong, Anesth Analg 2010;110:1170–9
4. Alhashemi, Can J Anaesth 2006;53:1200–6 RID, relative infant dose