AcuSolve Biomed Examples

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Page 1ACUSIM Software Confidential Information

AcuSolve Examples – Blood PumpAcuSolve Examples – Blood Pump

n The power law blood damagemodel gives excellentagreement with the data.

Pressure contours on blade surfaces




LVAD (heart pump!)LVAD (heart pump!)

n

ASAIO Journal – 2007Development and Validation of a Computational FluidDynamics

Methodology for Simulation of Pulsatile Left Ventricular AssistDevices

Authors: Richard B. Medvitz*‡, Eric G. Paterson*‡, James W. Kreider†, Keefe B.Manning†, Arnold A. Fontaine*†, Steven Deutsch*†

Institutional Affiliation: * Applied Research Laboratory, The Pennsylvania StateUniversity, University Park, Pa 16802




Example of Mesh Motion for PumpExample of Mesh Motion for Pump




Unstructured MeshUnstructured Mesh Computational velocity magnitude contours andComputational velocity magnitude contours andtangential velocity vectors at 6 mm from the fronttangential velocity vectors at 6 mm from the frontface of the LVAD with the mitral and aortic valvesface of the LVAD with the mitral and aortic valves

removedremoved..




Blood/Cancer Cell InteractionBlood/Cancer Cell Interaction http://www.ensight.com/cutting-edge-cfd-simulations-take-cancer-http://www.ensight.com/cutting-edge-cfd-simulations-take-cancer-research-to-a-new-dimension.htmlresearch-to-a-new-dimension.html

Meghan Hoskins, a Ph.D. candidate in the Bioengineering program at PennState, under the advisement of Robert Kunz, Ph.D. and Cheng Dong,Ph.D., is examining how cancer cells stick to white blood cells, thedefenders of the blood stream, and how the flow of blood affects thisadhesion. Her work, funded by the National Cancer Institute and the PSU Applied Research Laboratory, is based on the theory that, as cancer cellstravel through the blood stream, they are attracted to areas where white

blood cells are at work fighting inflammation.

Cancer Cell

Traverseswhite blood cell




Cell WorkflowCell Workflow




Lung AirflowLung Airflow

Figure 1: Virtual 3-D Airway TreeGeometry

Model which has 54,611 branches

Figure 2 shows the wall pressure

distribution for that 3500 branches. Thescale on the model is -0.08 (blue) to 3.35(red) Pascals. Meshing and solving of thefull virtual model is currently underway



ACUSIM Software Confidential Information

Adominal Aortic AneurysmAdominal Aortic AneurysmN u m C r

国立がんセンター

がん予防・診研究セン検ター

山本修司先生

SPIE 2006

Pre-operative Post Operative

解析メッシュ節点数 177,719 要素数 958,738 ４節点四面体( amira 使用 )

領域分割数 1非定常解析

400 steps (4 心拍） 428 MB 11.1Hr

解析メッシュ節点数 189,918 要素 1,015,905 ４節点四面体( amira 使用 )


400 steps (4 心拍） 456 MB 13.1 Hr




N u m C r

The bloodstream analysis of the cerebral aneurysmThe bloodstream analysis of the cerebral aneurysm

inlet

outlet1

outlet2

outlet3

浜松医科大学

医学部放射線医学講座

礒田治夫先生




N u m C rFlow Analysis in Cerebral AneurysmFlow Analysis in Cerebral Aneurysm ））

流線

解析メッシュ節点数 90,398 要素数 385,490 ４節点四面体( amira 使用 )


300 steps (3 心拍） 69.6 MB/cpu

1.97 Hr

領域分割数 1189 MB6.87 Hr




Animation of Flow in Aneurysms




Blood fill from sending blood vesselBlood fill from sending blood vesselN u m C r

岐阜県立多治見病院心臓血管外科

徳田順之先生

External Circulation from heart lung machine

送血管の例

4.1 l/min

The Gifu prefectural Tajimi hospitalheart blood vessel surgery




Blood FillBlood Fill （（ continuedcontinued ））

3.0 m/sec 2.0 m/sec 0.5 m/sec

Mesh Detailsnodes 321,678elements 1,806,203 (4 node tet)

Step1 ： Steady State run for initial condition for Step 2Step2 ： Transient DES Turb. Model

リスタート 100 steps

250 MB/CPU 5.9 Time




Case StudyCase StudyPeristaltic PumpsPeristaltic Pumps

Ø Inert/Sterile FluidsInert/Sterile Fluids

Ø Biomedical devices to corrosive fluids in chemical industriesBiomedical devices to corrosive fluids in chemical industriesUses “peristalsis” processUses “peristalsis” process

Ø Tubing under compression causes fluid to flowTubing under compression causes fluid to flow

Ø As Tubing returns to natural state, flow is induced to the puAs Tubing returns to natural state, flow is induced to the pu

An FSI study is required to predict the pump flow characteristicsAn FSI study is required to predict the pump flow characteristics

Compr essi

onRestitution

Flow in

Flow out

http://upload.wikimedia.org/wikipedia/commons/2/2a/Howworksmin.gif




Peristaltic Pump ModelPeristaltic Pump Model

Structural ModelStructural ModelDynamic Explicit AnalysisDynamic Explicit Analysis

Flexible Hose Modelled as Rubber Flexible Hose Modelled as Rubber

Ø Hyperelastic propertiesHyperelastic properties

Ø CC1010

=69000, C=69000, C0101

=173000,=173000,

DD11=1.45e=1.45e-8-8

36828 Linear Hexahedral Elements36828 Linear Hexahedral Elements

Total solution time = 6.1 sTotal solution time = 6.1 s

Angular velocity: 10.472 radians/secAngular velocity: 10.472 radians/sec

Casing and rollers modelled as rigidCasing and rollers modelled as rigidØ Casing and ends are fixedCasing and ends are fixed




Fluid ModelFluid ModelTransient analysisTransient analysis

Fluid properties to be viscous oilFluid properties to be viscous oilØ Density: 980 kg/mDensity: 980 kg/m33

Ø Viscosity: 0.5 kg/mViscosity: 0.5 kg/mss

Spalart-AllmarasSpalart-Allmaras turbulence modelturbulence model

72100 Linear Hexahedral Elements72100 Linear Hexahedral Elements

Inflow: Velocity-inlet conditionInflow: Velocity-inlet condition

Ø Initial stagnant conditionInitial stagnant condition

Outflow: Pressure-outlet conditionOutflow: Pressure-outlet conditionØ Outlet set to atmosphericOutlet set to atmospheric

pressurepressure

Peristaltic Pump ModelPeristaltic Pump Model




Enabling FSI Solutions with Abaqus/CAEEnabling FSI Solutions with Abaqus/CAE

FSI module available for Abaqus/CAEFSI module available for Abaqus/CAE

Ø

Easy-to-use workflow for FSIEasy-to-use workflow for FSIModule provides specific functionality for defining FSI modulesModule provides specific functionality for defining FSI modules

CFD Product supportCFD Product support

Ø AcuSolveAcuSolve




FSI WorkflowFSI Workflow




Post-process the CFD SolutionPost-process the CFD Solution




Post-process the FSI SolutionPost-process the FSI Solution




ConclusionsConclusions

n AcuSolve is a powerful general purpose CFD codel

The premier commercial finite element based CFD solver l

n Major focusl Robustness

l Speed

l Accuracy

l Functionality

l Ease of usewith AcuConsole

l

n Ideal for engineering and scientific applications

Documents

AcuSolve Biomed Examples