Adapt Your Life August 25th 2017

Kraft Pattern 2, 3, 4 - Hyperinsulinemia (Diabetes in Situ)

2

3

4

1

Ivor Cummins BE(Chem) Ceng MIEI

Kraft Pattern 2, 3, 4 - Hyperinsulinemia (Diabetes in Situ)

2

3

4

1

30

40

“The Earliest Laboratory Diagnosis for Diabetes”

4,004 NON-DIABETIC CAD Victims

Ages 18-80, across 24 countries…

More

Diabetics

!

Yet More

Diabetics

!

If

KRAFT

Tested

???

~7,000 CAD Victims…

Across All of Europe

Known

Diabetics

!

Non-Diabetic

CAD Victims

2015 Euroaspire - CHD and Diabetes Status

Ivor Cummins BE(Chem) Ceng MIEI

More

Diabetics

!

Yet More

Diabetics

!

Known

Diabetics

!

Non-Diabetic

CAD Victims

(supposedly…)

4,004 NON-DIABETIC CAD Victims

Ages 18-80, across 24 countries…

CAD Victims

All of Europe

If

KRAFT

Tested

?

“Those with cardiovascular disease not

identified with diabetes… are simply

undiagnosed” - Dr. Joseph R. KraftKNOWN

Diabetics

!

MORE

Diabetics

!

YET MORE

Diabetics !

If

KRAFT

Tested

???

All CAD Patients:Reality Bites.

2015 Euroaspire - CHD and Diabetes Status

Ivor Cummins BE(Chem) Ceng MIEI

SHC

INSULIN RECEPTOR

GRB2 / SOS

RAS

RAF

MEK

ERK1,2

PI3K-C1

IRS-1

Gets

SUPPRESSEDRemainsACTIVE

PI(3,4,5)P3

HYPERINSULIN

mTORC2

AKT/PKB

1 2

Ivor Cummins BE(Chem) Ceng MIEI

SHC

INSULIN RECEPTOR

GRB2 / SOS

RAS

RAF

MEK

ERK1,2

PI3K-C1

IRS-1

Gets

SUPPRESSEDRemainsACTIVE

PI(3,4,5)P3

mTORC2

Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated

Insulin Receptor Substrate-1Tyrosine Phosphorylation DIABETES, VOL. 50, NOVEMBER 2001

AKT/PKB

2

HYPERINSULIN

CONTROLDIABETIC

PARENTS

CONTROLDIABETIC

PARENTS

CONTROLDIABETIC

PARENTS

Ivor Cummins BE(Chem) Ceng MIEI

Skeletal Muscle Insulin Resistance in Normoglycemic Subjects With a Strong Family History of Type 2 Diabetes Is Associated With Decreased Insulin-Stimulated

Insulin Receptor Substrate-1Tyrosine Phosphorylation DIABETES, VOL. 50, NOVEMBER 2001

NO FAMILY

HISTORY

FAMILY

HISTORY

Insulin Tolerance Test

FAILED

KRAFT !

PASSED

KRAFT

Q: What would a Kraft Insulin Assay have told us?

A: All we needed to know - before they drifted to full diabetes…

30

40

Ivor Cummins BE(Chem) Ceng MIEI

They start younger too…like in this study.

30

40

Control Parent(s) Diabetic

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes N Engl J Med 2004;350:664-71 Ivor Cummins BE(Chem) Ceng MIEI

Impaired Mitochondrial Activity in the Insulin-Resistant Offspring of Patients with Type 2 Diabetes N Engl J Med 2004;350:664-71

They start younger too…like in this study.

30

40

Control Parent(s) Diabetic

Ivor Cummins BE(Chem) Ceng MIEI

Patterns of Insulin Concentration During the OGTT Predict the Risk of Type 2 Diabetes in Japanese AmericansDIABETES CARE, VOLUME 36, MAY 2013

Kraft predicts Full-blown T2D…2013 Study

DIABETES

INCIDENCE

11 Years Later

OR

IGIN

AL

Ivor Cummins BE(Chem) Ceng MIEI

The Human Chronic Disease Spectrum

Truly

NON

Diabetic

Full

Blown

Diabetes

Ivor Cummins BE(Chem) Ceng MIEI

All-Cause

MORTALITY

Ivor Cummins BE(Chem) Ceng MIEI

The Human Chronic Disease Spectrum

Fasting

Low Carb

Healthy Fat

HQ ProteinSun

Stress

SleepSuppExercise

Proc

Food

Ref Carb

/ Sugar

Veg

OilTruly

NON

Diabetic

Full

Blown

Diabetes

METABOLIC

MAYHEM

ANCESTRAL

HEALTH

Fixing it…with the 10 levers.

Ivor Cummins BE(Chem) Ceng MIEI

The Human Chronic Disease Spectrum

Fasting

Low Carb

Healthy Fat

HQ ProteinSun

Stress

SleepSuppExercise

Proc

Food

Ref Carb

/ Sugar

Veg

Oil

Full

Blown

Diabetes

METABOLIC

MAYHEM

Fixing it…with the 10 levers.

Ivor Cummins BE(Chem) Ceng MIEI

Low Trig/HDL ratio

Low PP Insulin Level

Low PP Glucose / A1c

Low GGT / Ferritin

Low Blood Pressure

High Adiponectin /

Low Leptin

Truly

NON

Diabetic

The Human Chronic Disease SpectrumFull

Blown

Diabetes

Fasting

Low Carb

Healthy Fat

HQ ProteinS S S

SuppExercise

Proc

Food

Ref Carb

/ Sugar

Veg

Oil

Low Trig/HDL ratio

Low PP Insulin Level

Low PP Glucose / A1c

Low GGT / Ferritin

Low Blood Pressure

High Adiponectin /

Low Leptin

Truly

NON

Diabetic

METABOLIC

MAYHEM

ANCESTRAL

HEALTHIvor Cummins BE(Chem) Ceng MIEI