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Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke, and Harry K. Genant J Bone Joint Surg Am Volume 90(Supplement 1):68-78 February 1, 2008 ©2008 by The Journal of Bone and Joint Surgery, Inc.

Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

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Page 1: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair

by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke, and Harry K. Genant

J Bone Joint Surg AmVolume 90(Supplement 1):68-78

February 1, 2008

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 2: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Volumetric quantitative computed tomography of the hip may be used to analyze bone mineral density in bone compartments and to accurately measure proximal femoral geometry.

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 3: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Multislice high-resolution in vivo computed tomographic images of the spine, rendered in three dimensions, showing normal (left) and osteoporotic (right) vertebrae (courtesy of Masako Ito,

MD, Nagasaki, Japan).

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 4: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Microquantitative computed tomogram of a vertebral body at 30-μm resolution, and generation of a micro-finite element model at the trabecular level (courtesy of Tony Keaveny, PhD, Berkeley,

California).

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 5: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Magnetic resonance image of the distal part of the forearm at approximately 150 × 150 × 500-μm in-plane resolution, creating a virtual bone biopsy from which three-dimensional volume-

rendered images are derived (courtesy of Felix Wehrli, PhD, Philadelphia, ...

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 6: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

High-resolution magnetic resonance images (upper left and upper right images), compared with a multislice spiral computed tomogram (lower left) and a detail contact radiograph (lower right),

all of a cadaveric section of the distal radius (courtesy of Thoma...

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 7: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Microquantitative computed tomograms of a healing femoral shaft fracture in a rat.

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 8: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Volumetric quantitative computed tomogram of a critical defect in a sheep model, showing callus formation with sagittal reformation and axial images (courtesy of Peter Augat, PhD, Salzburg,

Austria).

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.

Page 9: Advanced Imaging of Bone Macrostructure and Microstructure in Bone Fragility and Fracture Repair by Banu B. Kalpakcioglu, Saam Morshed, Klaus Engelke,

Serial radiographs (right) and axial computed tomographic images (left), showing progressive healing.

Banu B. Kalpakcioglu et al. J Bone Joint Surg Am 2008;90:68-78

©2008 by The Journal of Bone and Joint Surgery, Inc.