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Advanced Course on New Methods of Data Acquisition and Analysis in Biomolecular NMR
September 20-‐23, 2010, Swedish NMR Centre, University of Gothenburg http://www.nmr.gu.se/courses.html
Registration: contact Vladislav.Orekhov (at) nmr.gu.se
An intensive hands-‐on workshop will demonstrate how to combine novel experimental sampling approaches with spectral analysis and automation software, and how to use the methods on the high-‐performance biomolecular NMR EU e-‐Infrastructure. The workshops aim is to cover both theoretical and practical aspects of modern tools and provide hands-‐on training on NMR instruments and data processing facilities. Morning lectures will be complemented in the afternoons by experiment and processing sessions in small groups.
Speakers
Dr. Wolfgang Bermel (Bruker BioSpin, Germany) Prof. Martin Billeter (University of Gothenburg, Sweden) Dr. Rasmus H. Fogh (University of Cambridge, UK) Prof. Sebastian Hiller (University of Basel, Switzerland) Dr. Victor Jaravine (e-‐NMR, BMRZ Goethe-‐University, Germany) Dr. Krzysztof Kazimierczuk (University of Gothenburg, Sweden) Dr. Eriks Kupce. (Varian Inc.) Prof. Vladislav Orekhov (University of Gothenburg, Sweden) Prof. Markus Zweckstetter (MPI Biophysical Chemistry, Göttingen, Germany)
Organization Committee
Prof. Vladislav Orekhov, Swedish NMR Centre, University of Gothenburg Prof. Göran Karlsson, Swedish NMR Centre, University of Gothenburg Prof. Martin Billeter, Department of Chemistry, University of Gothenburg Dr. Victor Jaravine, e-‐NMR, BMRZ/Goethe-‐University, Germany
Notes
• No registration fee • Registration details will be posted at the workshop web page • The hands-‐on training limits the number of participants to ~20 • Requirement: familiarity with protein NMR (assignment, structure
determination) • eNMR VO registration is required http://www.enmr.eu/eNMR-‐
registration • Participants will present their current NMR project
SWEDISH NMR CENTRE
• Programme Time Mo Sep 20 12.30 – 13.00 Registration Entry hall 13.00 – 13.30 Martin Billeter, Göran Karlsson, Vladislav Orekhov Welcome and Information 13.30 – 15.00 Students presentationsi 15.00 – 18.15 Krzysztof Kazimierczuk How to (and how not to) apply Fourier Transform to non-uniformly sampled NMR signals Hands-on: processing with non-uniform Fourier transform 18.30 – 19.00 Get-together Entry hall Tu Sep 21 8.30 – 12.30 Eriks Kupce Fast Techniques in VnmrJ 10.15 – 10.45 Coffee break Library 12.30 – 14.00 Lunch 14.00 –18.00 Sebastian Hiller Automated Projection Spectroscopy (APSY): Applications to Proteins We Sep 22 8.30 – 12.00 Markus Zweckstetter Backbone resonance assignment using MARS/Analysis of dipolar couplings using PALES 10.15 – 10.45 Coffee break Library 12.00 – 13.00 Lunch
13.00 – 16.15 Martin Billeter Resonance assignments and 3D structure using spectral projections and decompositions Hands-on: PRODECOMP
16.15– 18.00 Rasmus Fogh Running programs and viewing results with CcpNmr Analysis Th Sep 23 8.30 – 10.15 Vladislav Orekhov Non-uniform sampling and Multi-Dimensional Decomposition 10.15 – 10.45 Coffee break Library 10.45 – 12.30 Wolfgang Bermel Fast methods and TopSpin 12.30 – 14.00 Lunch
14:00 – 15.30 Victor Jaravine e-NMR: Computational NMR Infrastructure in biomolecular life sciences and system biology Hands-on: work with web portals, CYANA and MDD portals
15.30 –18.00 Maxim Mayzel, Vladislav Orekhov Hands-on: NUS-MDD processing and targeted acquisition for real-time backbone assignment
Fr Sep 24 (optional follow-ups) Several course teachers are available for discussions. NMR experiments on samples brought by students
i As a part of the course syllabus, each participant presents himself and his/her ongoing or planned project, which is related to the topic of the course. In addition to the short oral presentation, the participants are encouraged to bring posters that will be viewed during the breaks.