Aging Matters Issue 6, 2014

No 6, 2014US $8.00/ EU €6.00/ GB £5.00 where sold

Dr. Richard Lippman looks into aldosterone

The ultimate AGE inhibitors5HTP the natural SSRI alternative Dr Ward Dean answers your questions

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Welcome

Who would believe that a lack of an adrenal hormone could be related to hearing problems? Yet, in our lead article, Dr. Lippman explains how the hormone aldosterone has been shown to improve hearing! The origination of this information was found in earlier research, much of which was unearthed by Dr. Jonathan Wright and his team. I think it just goes to show that ‘old’ information is not necessarily ‘out of date’ information. Indeed, it highlights that proper examination of the earlier publications can reveal important information- that even current research has not yet ‘rediscovered!’ In fact, it explains one of my jokes that I often say at meetings which is; “if you want to keep it a secret- publish it!”

Meanwhile, since the cross-linking (glycation) theory of aging remains VLJQL¿FDQW�ZH�DOVR�KDYH�DQ�XS�WR�GDWH�SLHFH�IURP�'U��0DULRV�.\ULD]LV�about the AGE inhibitors.

)XUWKHUPRUH��WKHUH�LV�D�UHPLQGHU�DERXW�WKH�EHQH¿WV�RI�WKH�QDWXUDO�DPLQR�acid 5-HTP and how it performs as well as the anti-depressive drugs. Plus, as usual more of your questions are answered by Dr. Ward Dean.

Cheers!

Phil Micans, MS, PharmB (GLWRU��$JLQJ�0DWWHUV��0DJD]LQH

Ward Dean Ward Dean, M.D., Medical Advisor

Declaration: The IAS Aging Matters™ magazine is intended for IAS private club members and focuses on the latest international nutritional, hormonal and drug therapies to help combat the signs of aging. These signs include the physical, mental and internal changes consisting of the diseases and disorders such as cancer, arthritis and senile dementias etc. However, the main focus is upon the prevention of such aging diseases and disorders for the ‘healthy-aging’ individual.

Copyright 2014: All copyrights are acknowledged. Whilst every effort has been made to ensure accuracy, no responsibility can be accepted for illustrations, photographs, artwork or advertising ma-terials while in transmission or with the publisher or their agents.

Disclaimer: All educational information is offered under IAS terms and conditions. This information does not replace the advice of your physician and restrictions may apply in some countries. The opinions expressed by the writers may not be those of IAS or the magazine. All prices shown are in US Dollars and are for reference purposes only and they do not include taxes (where applicable), nor do they include shipping & handling fees. Prices, conditions and terms are subject to change without notice.

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IndexWelcome � �3KLO�VD\V�WKDQNV�IRU�¿QGLQJ�WKH�WLPH� �The hearing hormone -Dr Richard Lippman on aldosterone 4The ultimate AGE inhibitors -Best approaches to combat glycosylation 85-HTP, the natural SSRI alterative � �7UHDWLQJ�GHSUHVVLRQ�QDWXUDOO\� ��Dr Ward Dean Q&A -Dr Dean answers your questions 17Featured products � �%HVW�VHOOHUV�DQG�QHZ�LWHPV� ��Testimonials & Explanations � �1LFH�SHRSOH��QLFH�FRPPHQWV� ��Complete product A-Z list and prices � �)LQG�HYHU\WKLQJ�LQ�VWRFN�KHUH� ��Condition cross-reference list -Find the right product for you 45Contact details -Get in touch with IAS today 50

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Researchers have discovered yet another hearing breakthrough that does not involve purchasing a hearing aid! With this new treatment, those with hearing loss caused by aging can enjoy increased sound volume and more importantly, improved word recognition.As a result of their restored hearing and comprehension, those with hearing loss can become more sociable again without the need for hearing aids. Another benefit of this treatment is that those who suffer from the need to urinate frequently suddenly experience improved bladder control. A third benefit is the eradication of the type of dizzy spells that occur when a patient stands up quickly after sitting for a long period of time.Patients enjoy all these benefits when they use eardrops that employ a special time-releasing mechanism for the hormone aldosterone. The eardrops are used in the morning so that the advanced time-release technology can release the natural hormone aldosterone slowly and evenly throughout the day in proximity to the cochlea, the hearing center of the ear. I have heard from numerous patients who are thrilled that these eardrops have allowed them to resume their formerly active social lives.

My experiences with aldosterone and hearing lossDuring the last thirty years, I have made many medical discoveries (including the nicotine patch) that have saved the lives of millions of people. I have also noticed that hormone deficiencies due to aging caused needless suffering in millions of people. This led me to the conclusion that the loss of hormones through shrinking endocrine glands can cause hearing loss and numerous other illnesses encountered during aging. One key hormone that declines with age is aldosterone. I have found that patients with hearing loss were temporarily helped by consuming aldosterone 125 mcg capsules two to five times daily. However, this effect was only temporary because natural aldosterone is metabolized quickly and excreted from the body. This meant that taking a large quantity of capsules throughout the day was necessary because aldosterone has a short metabolic half-life. I believed that there had to be a better way to administer aldosterone and in 2011, I devised my Lippman Protocol, in which patients improved their hearing by taking natural aldosterone capsules some days and synthetic aldosterone (Florinef®) other days. For many patients, this protocol simplified the need to take hearing meds, but I was still dissatisfied. Then, in 2014, I devised

Aldosterone, The Hearing HormoneImproved word recognition for those with hearing lossBy Dr. Richard Lippman

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yet another method of improving hearing by employing the latest in time-release technology. I applied this new, cutting-edge technology to the natural hormone aldosterone and discovered, much to my amazement, that word recognition, tinnitus and decreased bathroom visits were the additional fruits of my research!History of attempts to improve hearing More than a decade ago in Rochester, New York, scientists correlated hearing loss with decreased blood levels of aldosterone. They discovered that the more aldosterone present within the bloodstream, the better the hearing. The National Institute on Aging (NIA) verified this important research (1, 2, 3 and 5). Interestingly, people with hearing loss have, on average, less than half as much aldosterone in their blood as those with normal hearing. I’ve seen relatives of mine with hearing loss have one fourth to one sixth as much aldosterone as those with normal hearing.Activating rows of hair cells that transmit sound to the brainThe inner ear contains approximately 15,000 hair cells that vibrate to sound. They are divided into five rows and aldosterone appears to impact them. Aldosterone and fludrocortisone trigger pure-tone hearing thresholds by activating these five rows of hair cells in both ears. The result is increased sound volume in both the human voice and interfering background noises. However, word recognition is only partially remedied. In my lectures in Sweden, I made the following statement on this subject:“Apparently, the synthetic aldosterone drug, Florinef® (fludrocortisone) acts only on some inner-ear hair cell receptor sites while bioidentical (natural) aldosterone acts on all sites. Sound volume increases but there is not necessarily better word discrimination. This duel receptor-site action triggers an 85 millivolts threshold of electrical conductivity through the nerves of the inner ear. This trigger also depends upon a balanced electrolyte ratio of potassium and sodium. Thus, this combined hormone and electrolyte action produces significant sound-volume hearing improvement, but rather marginal improvement in word recognition since only two of the five rows control word recognition and they are only marginally activated (4).”Then in 2008, other researchers at the University of Portland in Oregon discovered that there was a reversal in hearing loss with aldosterone by increasing sodium transport in mice. Apparently, the natural hormone aldosterone increases sodium versus potassium in the nerve endings in the cochlea (inner ear). Indeed, researchers verified that the physiology of inner and middle ear improves somewhat with aldosterone (5). However, the synthetic version of aldosterone, fludrocortisone, seems to attach

so completely to the aldosterone receptor sites that it prevents natural aldosterone from fully activating its own receptors.Eminent Harvard graduate and antiaging specialist, Dr. Jonathan Wright, of the Tahoma Clinic in Renton, Washington found that one patient with Meniere’s disease improved his hearing by 30 decibels at 250 Hz when 125 micrograms of bioidentical (natural) aldosterone were consumed twice daily for seven months (4). I confirmed these results by improving patients’ hearing by more than 30 decibels at 3,000 Hz with my special protocol. This latter result is especially important since 3,000 Hz falls squarely inside the human vocal range. At this approximate 3,000 Hz vocal level, patients’ hearing could be improved by as much as 40 decibels, but only after several months of applying my 2011 Lippman Protocol. There was a problem, however, that was that word recognition was impaired and sometimes non-existent and difficulties with tinnitus continued.

Possible side effectsRegarding adverse effects, Dr. Wright has stated: “None of the people I’ve worked with have had any adverse effects from aldosterone therapy, likely because the use of bioidentical, physiologic-dose aldosterone restores levels to those that would be found in the body anyway” (4).In my research, I found that not everyone wants a 40-decibel enhancement. Such an enhancement can typically cause street noises to become too loud and even necessitate wearing earplugs at movie theaters. At times, due to this therapy, patients are forced to cover their ears tightly when an emergency vehicle drove by. In addition, I found that greatly enhanced hearing necessitates remembering to raise one’s voice during a conversation in order to be clearly heard by those with normal hearing. Dr. Wright and I confirmed that hearing volume improved dramatically when taking aldosterone and that forgetting to take it resulted in an unfortunate and dramatic return to hearing deficiency, tinnitus, and possible social isolation.We tested urine levels of aldosterone and confirmed that very low scores of below 5 micrograms per 24 hours were found in hearing deficient patients compared to scores of 20 to 30 micrograms per 24 hours in people with normal hearing. In fact, Dr. Wright’s 84-year-old patient consumed natural aldosterone capsules and increased his sound volume from 23 to 91 percent in his right ear and from 3 to 81 percent in his left ear (4).How do hormones and nutrients impact hearing?Low aldosterone is often seen as a biomarker for aging. Aging causes imbalances in the circadian rhythm (sleep cycle), which often result in the adrenal glands producing more and more of the stress hormone cortisol and less and less of other critical hormones such as aldosterone and DHEA, (an anabolic hormone that builds new tissues). The excess cortisol causes insomnia and unnecessary destruction of the body’s tissues (catabolic), while simultaneously decreasing aldosterone and causing hearing loss, frequent urination and declining DHEA. Low aldosterone may also lead to symptoms such as dizziness,

“Dr. Wright and I confirmed that hearing volume improved

dramatically when taking aldosterone”

Schematic shows the inner workings on the ear.


low blood pressure, thirst, dehydration, and salt cravings. Many of these symptoms result in imbalances in the potassium /sodium ratio that leads to fatigue and cellular energy loss in the inner ear’s 15,000 hair cells.Externally, signs of significant dehydration can be seen in people with fine lines, pinched faces, sinuous necks and a profound daily need for cosmetic lotions that superficially moisten their skin (6). Thus, a billion dollar cosmetic industry continues to sell their moisturizing and anti-wrinkle creams while the underlying medical problems, namely low hormone levels, remain untreated.In addition to low aldosterone and an imbalance in potassium and sodium, other vital nutrients may be lacking. Vitamins B12 (methylcobalamin preferred), folate (methylfolate – NOT folic acid) and oxytocin are nutrients essential to normal hearing. Interestingly, hearing loss may sometimes be reversed if 5,000 units of vitamin D3 are taken as a daily supplement.Note: Some prescription drugs such as Aldactone® (spironolactone) can impair hearing. (7)

Current hearing enhancement researchMuch to the astonishment of my colleagues, I discovered that a patient should consume only one 125 mcg capsule of natural aldosterone daily and that it should be taken in the morning on an empty stomach. For those over the age of 50 who often have impaired stomach absorption, I recommend drinking 4 ounces of grapefruit juice with the capsule. My natural aldosterone therapy improves hearing volume by more than 30 decibels when continued for several months. This decibel quantity is huge: 30 decibels-plus means the difference between deafness and fairly normal hearing. For example, after following the Lippman Protocol for about a month, the hearing-impaired are able to carry on a conversation at a loud party with high volume background music. Sufficient hearing at loud parties becomes possible despite having consumed only a single capsule 15 hours earlier in the day.

The Lippman one-capsule-daily protocol for increased volume onlyOn the morning of day one of the Lippman Protocol, take 20 micrograms of fludrocortisone with filtered water. Over the next two days, take one capsule of 125 micrograms of aldosterone daily before breakfast. On the fourth day, repeat the cycle, starting with again with fludrocortisone. This regimen will ensure constant high-decibel enhancement, except during sleeping hours, in which reduced hearing and increased tinnitus recur. For greater absorption into the bloodstream, I recommend drinking grapefruit juice with the aldosterone capsules. But do not use grapefruit juice with fludrocortisone (or for that matter any other prescription drug). Also, notice that only tiny, judicious microgram doses of aldosterone and fludrocortisone are employed. According to Europe’s foremost endocrinologist, Thierry Hertoghe, MD, use only the smallest, most judicious dose possible for efficacy. More is not better when it comes to

all hormones and nutriceuticals. Mega dosing is a mistake. This advice helps to prevent the serious side effects often seen when hormones and nutriceuticals are used excessively. Do not mega dose! For example, 100 micrograms of fludrocortisone can cause sleepiness and lethargy.On the other hand, in patients who have difficulties with word recognition, I recommend the all new aldosterone product, Aldo-Spray™ eardrops, which slowly time-releases aldosterone, thus allowing for improved word recognition. Aldo-Spray™ use improves sound volume and word recognitionAldo-Spray™ is easy to use. Upon waking, simply tilt your head to each side and press the plunger on the applicator bottle to enable a single dose of Aldo-Spray™ to enter each ear canal. Wipe off excess fluid with a paper towel. Most people will notice some hearing improvement after about one hour; a hearing improvement of approximately 30 decibels to 40 decibels occurs two to three hours after application. In some people, both hearing and word recognition continue to improve throughout the day. In addition, tinnitus subsides throughout the day but returns at night, when aldosterone in the body returns to a deficient level. Before bedtime, you should gently clean your ear canals by using a cotton swab or by washing them out with soap and water.Treatment of the ear canals before useBefore using Aldo-Spray™, be sure to check with your hearing specialist to determine that you don’t have a fungal growth in your ear canals. A typical symptom of fungal growth is itchiness in the ear. Ear canal fungal growth may be treated with a synthetic anti-fungal medication like Nystatin©. However, I’d strongly recommend using a completely natural solution called Pro-Ear™ that is available from several online retailers. Old habits are hard to breakRecently, two physician friends were skeptical and feared changing their old habit of recommending only hearing aids to their patients. They asked me why I bothered with a bunch of capsules or sprays. “Why not just buy a hearing aid?” one ear, nose, and throat doctor asked me. I answered him with a question: “What makes better medical sense: taking one capsule or spray daily and correcting a hormone deficiency or amplifying the volume on an already damaged hearing system?” My question flummoxed and silenced both of them.We should be enjoying our golden years without high-volume hearing aids distorting already damaged hearing systems. You decide. One capsule/ one spray a day works!References1. Tadros, SF et al, Nov. 2005. A Possible Protective Hormone against Presbycusic. Hearing Research, 209 (1-2), pp. 10-18.2. Trune, DR and Kempton, JB, May 2001, Aldosterone and Prednisone Control of Cochlear Function in MRL, MpJ-Fas (1pr) Autoimmune Mouse Ear. Hearing Research, 155 (1-2), pp. 9-203. Trune, DR et al, Feb. 2006. Mineralocorticoid Receptor Mediates Glucocorticoid Treatments Effects In The Autoimmune Mouse Ear. Hearing Research, 212 (1-2), pp.22-32.4. Wright, JV. Oct. 2008, Don’t Go Deaf, Blind, or Lose Your Mind! Nutrition & Hearing, Vol. 15, Issue 8, pp. 1-7.5. Otolaryngology Head Neck Surgery, Nov. 2008.6. Hertoghe, T. May, 2010, Picture Atlas of Endocrinology & Hormone Therapy, SA International Medical Books, Windhof, Luxembourg. 7. Laryngoscope, Feb. 2002.

“What makes better medical sense: taking one capsule or... amplifying the volume on an already damaged hearing system?”

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Dramatically Improves HearingResearch has shown people who suff er from hearing loss have half as much aldosterone in their blood as a person with good hearing, with its unique delivery method Aldo Spray™ is a breakthrough approach to age related hearing decline.

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EARDROP

We’ve known for several decades that the process of gly-cosylation is one of the most important causes of aging, perhaps equally as important as the process of oxidation. During our daily metabolism, sugar molecules (such as glucose and fructose) and reactive aldehydes and/or ketones may combine to any free amino groups on proteins, a process called non-enzymatic glyco-sylation (glycation). This reaction is called the Maillard reaction (Fig. 1). The Maillard reaction results in a glycated protein (i.e. a protein carrying a sugar [or similar molecules] on it). This glycated protein (called an Amadori product) may then react with any other proteins, resulting in irreversible bonding between the two. This bonding pro-cess is named ‘cross-linking,’ and it is present in all ageing organisms.

Type A inhibitorsPrevent Sugar Attachment1. Pyridoxical-5-phosphate2. Aspirin

SchiffBases

AmadoriProducts

AGEAdvanced Glycation

Endproducts

Protein

ReactiveIntermediates

Type B inhibitorsBlock formation of Crosslinks1. Metformin2. Aminoguanidine

Type E inhibitorsPrevent Formation of AGEs from Amidori Products1. Metformin2. Aminoguanidine

Type F inhibitorsCrosslinkage and AGE Breakers that can break crosslinks after they form1. ALT-7112. Phanacylthiazolium bromide (PTB)

Type C1 inhibitorsChelating Agents1. EDTA2. PenicillamineType C1 inhibitorsAntioxidants1. Vitamin C2. Vitamin E3. Lipoic Acid

Type D inhibitorsTrap Reactive Carbonyl Intermediates1. Metformin2. Aminoguanidine3. Carnosine4. L-Arginine

+glucose

Fig, 1. Pathway of advanced glycosylation, from Schiff bases to AGEs over time. (22)

Affected molecules can be anything from collagen and elastin, to enzymes and immune-proteins. Facilitators during cross-linking are the carbonyl groups (+ C=O -) which act like glue, fixing the two proteins together. Carbonyls are chemical groups which are formed as a result of a sugar (or an aldehyde, ketone or free radical) reacting with amino acids on a protein. In addition, carbonyls can be formed in other situations involving lipids or DNA, so they are not necessarily restricted to proteins. Carbonyls may thus cause not only protein-to-protein cross-linking, but also protein-to-DNA, or protein-to-lipid cross-linking, which is equally damaging to the organism. A condition called ‘carbonyl stress’ has been described. It involves increased levels of reactive carbonyl compounds which make cross-linking much more likely (1) and result in loss of function.Cross-linking results in formation of large insoluble aggregates of damaged proteins in the tissues. These aggregates have been named AGEs (Advanced Glycosylation End products) (or ‘post-Amadori products’, or ‘glycotoxins’) and may then go on to interact with free radicals and cause further tissue injury, through chronic oxidation. Although a steady rate of AGE formation happens as a result of normal aging (starting after the age of 20), formation of AGEs is ac-celerated during hyperglycaemic states such as diabetes. Copper, iron and other metals may hasten AGE formation.Once formed, AGEs inhibit cellular transport processes, stimulate cells to produce more free radicals (such as superoxide and nitric oxide), and activate pro-inflammatory cytokines such as Tumour Necrosis Factor alpha (TNF-a) and interleukin 6. In addition, some AGEs are immunogenic (causing age-related auto-immunity) or mutagenic (increasing the risk of cancer), whereas others increase the activity of adhesion molecules, reduce protein degradation rate and reduce cell proliferation--all of which ensure that the risk of degener-ative disease is increased. Also, AGEs stimulate apoptosis, resulting in excessive loss of cells contributing further to the risk of degener-ation. Some AGEs up-regulate genes which are involved in chronic inflammation reactions.An important product of cross-linking is Glucosepane (Fig. 2). This derives from D-glucose, and is a lysine-arginine protein advanced glycation end product. Currently, it has been impossible to break this bond and reverse its effects, despite intense research into the matter. It is present in molecules such as collagen and crystalline in the eyes.

Fig. 2. Making Glucosepane. Dr. David Spiegel’s group’s approach to making glucosepane. Two low-cost, common laboratory chemicals are combined in several steps to give the precursor to glucosepane, which can easily be used to make glucosepane-linked amino acids or peptides. This artificially-produced glucosepane can now be used to develop reagents that can rapidly and specifi-cally detect proteins that have been crosslinked by it. The development of such reagents is, in turn, a significant enabling technology for the development and testing of candidate glucosepane-breaking drugs.

ReadilyAvailableStarting

Materials

Several Synthetic Steps

Glucosepane

H2NO

OOH

N

N

N NH

HHO

NH2

HO

OH

At the clinical level, cross-linking contributes significantly to diabetic complications, lower immunity and increased risk of cancer, atherosclerosis and hypertension, Alzheimer’s disease (through the formation of amyloid, which is a type of AGE), cataract, kidney damage, skin ageing, and other age-related diseases (2).The process of cross-linking through glycation was hitherto thought to be irreversible, and this was one typical example of the immu-tability of ageing. There are many compounds aimed at preventing cross-linking, but during the past several years, new products have

The ultimate AGE inhibitorsBy Marios Kyriazis, M.D.


9

also been developed directed specifically at breaking the abnormal bonds between already cross-linked proteins, practically reversing protein ageing (3). Both classes of drugs, the cross-link inhibitors and the cross-link breakers, have been found to offer remarkable benefits at the clinical level, although some of these compounds suffered from commercial problems.

Cross-link InhibitorsThere are several commercially available cross-link inhibitors. Examples of these include carnosine, aminoguanidine, metform-in, acarbose, benfotiamine, and pyridoxamine. Some of these (like acarbose and metformin) are already in use as anti-diabetic drugs--but new research coming to light is now emphasizing their additional anti-cross-linking effects. Other not yet widely available inhibitors are penicillamine, Tenilsetam, OPB9195, phenazinediamine (2,3-di-aminophenazone), and several hundred others still in development (4), including derivatives of aminoguanidine.Many cross-link inhibitors are nucleophilic traps (scavengers) for re-active carbonyl intermediates. They are also copper chelators, and so they minimise the risk of both cross-linking and consequent age-re-lated damage. In addition, they block soluble receptors (sRAGEs) or specific receptors (RAGEs) which recognize AGEs. Some soluble receptors circulate freely, whereas specific ones can be found on mac-rophages, fibroblasts and endothelial cells. When an AGE molecule interacts with a RAGE it forms an adduct which is then prone to create more damage through oxidation and increased metal toxicity. The following is a list of some common or relevant anti-glycators. This should not be considered exhaustive, but is merely meant to act as an initial stimulus and form the basis of further self-study, in association with a qualified practitioner (Fig. 3).

Fig. 3. Glucosepane levels in human skin collagen rise with age. Redrawn from Sell et al, J Biol Chem. 2005 Apr 1;280(13):12310-5. PMID: 15677467.

Age (years)

2500

2000

1500

1000

500

00 20 40 60 80 100

Gluc

osep

ane (

pmol/

mg co

llage

n)

CarnosineThe dipeptide carnosine (beta alanyl- L-histidine) is a naturally-oc-curring agent found in muscle and nervous tissue (5). Carnosine has shown a lot of promise as one of the most promising cross-link inhibitors. It has multiple actions and as such it has been called a pluripotent agent. One way carnosine works is by scavenging for free carbonyl groups. Carnosine is one of the few cross-link inhibitors that is not only active against protein-to-protein cross-linking, but also against protein-to-DNA cross-linking (6).

Another important carnosine activity is ‘carnosinylation’, which is a process whereby carnosine attaches to the protein bearing a carbonyl group, thus blocking the carbonyl from attaching to another protein. It is just like placing a piece of paper (carnosine) between two pro-teins bearing glue (carbonyls). In other words, carnosine reacts with carbonylated proteins to form carnosine-carbonyl-protein adducts. These adducts are then removed by proteolysis and degradation. Carnosine has a direct antioxidant action, and it also has a sparing ef-fect on other antioxidants such as glutathione. It is a strong chelator of copper and can reduce copper-mediated damage during AGE activity (7). Finally, it has a possible, yet unconfirmed, bond-breaking capabili-ty by dissolving certain bonds (S-S bonds) on cross-linked proteins.At the clinical level, carnosine reduced urinary products of free radical and glycosylation metabolism in humans (8). One of the most important developments regarding carnosine is its ability to prevent and cure age-related cataract, and possibly glaucoma and other age-related eye conditions (9). In this respect the form of carnosine used is N-acetyl-carnosine. This curative action of carnosine is perhaps related to its ability to stimulate proteolysis and thus dissolve protein aggregates in the lens.The dosage of carnosine remains a contentious issue. Some author-ities suggest 1000 mg a day (or even more), while some others are more conservative, suggesting 200-500 mg a day.

MetforminMetformin (brand names Glucophage®, Metforal®) is a standard anti-diabetic drug (dimethyl-biguanide) used worldwide against both insulin-dependent and non-insulin-dependent diabetes. Although it is used primarily to increase peripheral sensitivity to insulin and lower blood glucose, metformin has several other important actions which are not yet appreciated by many physicians.Metformin lowers cholesterol, reduces body fat, stimulates antioxidant defences and is also an effective inhibitor of glycation. It reduces the formation of AGEs, particularly those affecting collagen, and prevents diastolic stiffness in the myocardium. It has direct anti-glycation ef-fects and improves cross-linking induced damage to nerves in diabetic rats. Its main mechanism of action is its carbonyl trapping ability (10).In a recent clinical trial the effect on metformin on methylglyoxal was studied in patients with diabetes. Metformin significantly re-duced methylglyoxal and thus reduced the effects of hyperglycaemia (11). Methylglyoxal, and the related compound, glyoxal, are both reactive carbonyl agents (alpha-dicarbonyls) which are blocked by the guanidine molecule, (remember that metformin is a guanidine-con-taining drug). Specifically, the guanidine moiety of metformin combines with methylglyoxal dicarbonyls to form guanidine-di-carbonyl adducts which are then eliminated from the tissues. With reduced amounts of carbonyl groups in the tissues, the likelihood of cross-linking is reduced. This mechanism of action is similar to that of aminoguanidine, which, as the name suggests, is also a guani-dine-containing molecule.More recent experiments show metformin to have widespread activ-ities as a cross-link inhibitor. It reduces cross-linking of fibrin pro-teins which take part in the clotting of blood. Exaggerated cross-link-ing of fibrin results in abnormal blood clotting, and therefore an increased risk of thrombosis (and consequent myocardial infarction or stroke). Metformin reduces fibrin cross-linking and therefore, ulti-mately, reduces the risk of thrombosis.In summary, with regards to glycation, metformin has a dual effect. It normalizes blood glucose (a well-known and established activi-ty) plus, as new research is revealing, it is an effective inhibitor of cross-linking through carbonyl trapping.Metformin should be used under medical supervision with monitor-ing of liver and kidney function. The dose is 500 mg twice to three


times a day. Dr. Ward Dean recommends that everybody over the age of 40 should be taking metformin, and research into the anti-gly-cation benefits of metformin supports this recommendation as a preventative anti-AGE drug.

AminoguanidineAn agent structurally similar to metformin is aminoguanidine (Pimagidine). Aminoguanidine has been studied extensively with encouraging reports. As with metformin, aminoguanidine is also a guanidine-containing agent, and therefore also acts as a carbonyl trapping agent. Aminoguanidine was one of the first AGE inhibitors, introduced in 1986 as a trap or scavenger of reactive carbonyl groups. Aminoguanidine works by forming guanidine-dicarbonyl adducts, thereby reducing the numbers of free carbonyl groups. In particular, it is active against certain aldehydes which contribute to cross-link-ing (e.g. alpha-oxoaldehyde, and malondialdehyde). Aminoguanidine is active mainly during the early stages of glycosylation.It is an effective inhibitor of cross-linking initiated by glucose molecules, but not as effective in situations involving ribose-related cross-linking. In any case, it prevents collagen cross-linking in ten-dons and skin which shows its potential for prevention of muscle and joint age-related stiffness and skin ageing (wrinkles). Recently, researchers confirmed that aminoguanidine is useful in improving wound healing, a property shared with carnosine. The mechanism is mainly due to its anti-glycation and collagen improv-ing effects (12). It limits the development of diabetic complications in animals, and it has shown promising actions in improving diabetic nephropathy in double blind human trials. In addition, it is a weak copper chelator. Copper chelation is important in AGE induced damage, as high amounts of free copper are more likely to increase AGE-induced injury. In association with kavalactones, another group of anti-aging compounds, it was found to chelate copper and iron, and also reduced glycosylation products (13).In a study, aminoguanidine was given to a group of rats daily for several weeks. The researchers found that AGE levels in the eye were significantly reduced, and loss of visual cells was also minimised. This indicates an anti-glycation effect on both the molecules (AGEs) and the receptors for these molecules (RAGEs), resulting in a protec-tive effect on the retina (useful protection against retinal degenera-tion) (14). This AGE blocking effect of aminoguanidine on the retina has been shown in several experiments in the past, and it seems to be very relevant in preventing age-related degeneration of the retina.Aminoguanidine prevents cardiac enlargement by reducing the risk of glycation-induced damage to cardiac and aortic collagen (15). In addition, it prevents cross-linking between lipoproteins (proteins carrying fat molecules) and therefore reduces the risk of blockage of the arteries, particularly the small arteries that feed the nerves.It is such a strong carbonyl scavenger that it can sometimes result in excessive removal of carbonyl groups (which, in small quantities, are necessary for the normal functioning of the metabolism). This can, on rare occasions, give rise to toxicity, particularly if aminoguani-dine is used in excessive doses (over 600 mg daily without medical supervision). In theory, the concomitant use of pyridoxamine (see be-low) can reduce the likelihood of this potential problem. Aminogua-nidine has other actions which complement its anti-glycation effects. For example, it reduces inflammation by interfering with the nitric oxide actions (16). Acting as an α-Dicarbonyl trap, aminoguanidine showed some initial promise as a glucosepane blocker. However, more research is needed in this respect.Aminoguanidine has a short half-life in the plasma, so it must be given in relatively high doses in order to continuously trap AGE compounds. The dose is 150 mg once or twice a day, but diabetics sometimes use double this dose. Side effects are rare and mild and in-

clude nausea or headache. There are two main varieties of aminogua-nidine, the hydrochloride and the bicarbonate variety. Although the bicarbonate variety is more commonly available, the hydrochloride version is believed to be the most active (bioavailable) as it is more soluble. Aminoguanidine may be used together with carnosine which is active both in early and late stages of glycosylation, or together with metformin, particularly in diabetics.More cutting-edge ways of administering aminoguanidine include the novel concept of bio- conjugation, i.e. the attachment of the aminoguanidine molecule to gold nanoparticles (17). As mentioned above, high doses of aminoguanidine may cause side effects, but conjugation with nanoparticles may help reduce these adverse effects and maximise the positive effects.

AcarboseAnother drug used in diabetes is Acarbose (Glucobay®), an alpha-glu-cosidase inhibitor. Alpha-glucosidases are enzymes which facilitate the breakdown of complex carbohydrates (such as starch) into small-er sugar molecules which are then absorbed through the intestinal wall. Acarbose blocks this, thereby inhibiting the absorption of certain sugar molecules such as maltose and sucrose, while allowing the absorption of glucose and lactose, which are needed for energy. In this way the overall absorption of carbohydrates is reduced and this lessens the risk of glycation-induced damage and AGE formation.Acarbose’s main benefits include a reduction of blood lipids (reduced uptake of triglycerides), an aid to weight loss, and important anti-gly-cation activity (18). As with metformin, acarbose has hitherto been used primarily to reduce blood glucose and therefore improve the symptoms of diabetes. However, new research is unravelling its an-ti-glycation properties which are in addition to its glucose-lowering actions. For this reason, acarbose is not only indicated for treatment of diabetes, but also for treatment of diabetic complications and other AGE-related damage. Several studies have shown that Acarbose reduces the formation of glycated proteins (including the glycated haemoglobin A1c, which is a marker for diabetes). Acarbose is safe but it may have side effects such as abdominal pain and cramps, bloatedness and diarrhea. These are due to excessive amounts of unabsorbed carbohydrates in the bowel. The usual dose is 50 to 100 mg three times daily. For greater benefits, it may be worth using acarbose together with other cross-link inhibitors such as carnosine. Acarbose is best taken by chewing the tablets, usually just before or during meals.

PyridoxamineThere are three different vitamers of Vitamin B6: pyridoxal, pyridox-ine (the form traditionally used in supplementation) and pyridoxam-ine. All of these are naturally occurring. Pyridoxamine (brand name Pyridox-Pro™) is found in animal sources, whereas pyridoxine is also found in plant sources. All three variants have a certain degree of an-ti-cross-linking actions, but pyridoxamine is the strongest and most significant. Trials are in progress to evaluate the product’s safety and efficacy in preventing diabetic complications.Pyridoxamine prevents the formation of AGEs by 25-50%, and ame-liorates diabetes-related kidney dysfunction (it improves albuminu-ria, plasma creatinine and hyperlipidemia). It works by trapping reac-tive carbonyl groups and exhibits free radical scavenging properties. It is most effective in the later stages of glycosylation and therefore, for full protection, it may be used together with aminoguanidine which is active in the early stages of glycosylation. In fact, compar-ison studies with aminoguanidine suggest that although both are effective against AGEs, pyridoxamine may be a more versatile agent to use against glycosylation in order to avoid the low risk of potential toxicity problems with aminoguanidine mentioned above.Pyridoxamine does not affect the levels of blood glucose. It inhibits both methylglyoxal and glycoaldehydes which are most active follow-


ing lipid peroxidation. It forms methylglyoxal-pyridoxamine dimers which are inactive and eliminated easily. There have been reports of neurotoxicity from using very high doses of pyridoxine, but the use of pyridoxamine is thought to be free from these side effects. The reason is that pyridoxamine needs to be phosphorylated (i.e. it needs the addition of phosphate on the main molecule) before it can become active.

Lalezari-Rahbar (LR) compounds These are aromatic organic acids named after the developers, and are relatively new AGE inhibitors. Apart from anti-diabetic and anti-glycation effects, these have also been shown to have lipid-low-ering benefits. Although several of their benefits are similar to those of aminoguanidine, these LR products are not carbonyl blockers. They are, however, good heavy metal chelators, like carnosine and aminoguanidine. It is believed that chelation alone, in the absence of carbonyl trapping, can be a good way of blocking AGEs.Less useful anti-glycators (either because of a weak effect or because they are not easily available), are:• Penicillamine. Although not a potent anti-glycator, penicillamine can be used to improve arterial wall function which has been compromised due to glycation. In this respect, it has been used in association with vitamin E (19).• Tenilsetam (3-2-thienyl-2-piperazinone). This been used as a brain stimulant (nootropic). New research has examined its anti-AGE actions and its significant glycosylation-inhibiting benefits. It works like most cross-link blockers, namely by carbonyl trapping. In addition, Tenilsetam has antioxidant activities and copper chelating properties.• OPB-9195 (2-isopropyli-denehydrazono-4-oxo-thiazolidin-5-ylac-etanilide). This carbonyl-trapping agent is a synthetic thiazolium de-rivative which inhibits cross-linking and improves kidney function. It also improves vascular function and reduces arterial thickening.• Pentoxifylline (brand name Trendal®) is normally used to improve circulation to the extremities.• Kinetin (furfuriladenine) brand name Kinerase®. In a study, kinetin inhibited carbonyl activity and reduced AGEs by up to 68%, but there are no new studies to confirm these benefits.• Kavalactones are some promising and relatively new inhibitors of protein glycation. These are also effective against lipid peroxidation (13).• Benfotiamine. This is a very promising compound which has sever-al other actions as well as being anti-glycator. In a study, a combina-tion of pyridoxamine and benfotiamine was found to improve pain, reduce inflammation and improve the quality of life in osteoarthritis patients (20).

Cross-link BreakersParadoxically, what is probably the most important cross-link break-er is the no-longer-available drug ALT-711, an orally active com-pound. This is a thiazolium product (dimethyl-3-phenacyl-thiazoli-um chloride) formerly manufactured by the Alteon Corporation in the US. A related compound is PTB (dimethyl-Phenacyl-Thiazolium Bromide), which has actions similar to the chloride variety. ALT-711 is not an enzyme as such, but had enzymatic properties. It was shown to actually break the covalent bonds between cross-linked proteins and free the proteins which were then able to function again nor-mally. It had also been studied in a number of human clinical trials. It was found to be effective in reversing some of the complications of diabetes, improving myocardial and arterial stiffness, heart failure, and reducing blood pressure.Unfortunately, its production has been stopped, despite showing prom-ising effects. A main reason for this was the lack of funds available to the manufacturing company. Nevertheless, research into this com-pound continues and many of its effects are now better clarified (21).

SummaryOne of the most useful, well-studied and relevant anti-glycators is aminoguanidine, with others such as carnosine, metformin and acarbose being close second. There are many others in the pipeline, but it is rather disappointing that despite intense research there are no efficient cross-link breakers available. The problem of glycation is proving to be a tough one to solve, but nevertheless it may be possible to delay the process by using existing proven anti-crosslinking com-pounds such as aminoguanidine.

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References1. Ergin V, Hariry RE, Karasu C. Carbonyl stress in aging process: role of vitamins and phytochemicals as redox regulators. Aging Dis. 2013;4(5):276-94. 2. Ansari NA, Moinuddin, Mir AR, Habib S, Alam K, Ali A, Khan RH. Role of early glycation amadori products of ly-sine-rich proteins in the production of autoantibodies in diabetes type 2 patients. Cell Biochem Biophys. 2014;70(2):857-653. Nagai R, et al. Chelation: A Fundamental Mechanism of Action of AGE Inhibitors, AGE Breakers, and Other Inhibi-tors of Diabetes Complications. Diabetes March 2012 vol. 61 no. 3 549-5594. Reddy VP, Beyaz A. Inhibitors of the Maillard reaction and AGE breakers as therapeutics for multiple diseases. Drug Discov Today 2006;11:646–6545. Budzeń S, Rymaszewska J. The biological role of carnosine and its possible applications in medicine. Adv Clin Exp Med. 2013 Sep-Oct;22(5):739-44.6. Pepper ED, Farrell MJ, Nord G, Finkel SE. Antiglycation effects of carnosine and other compounds on the long-term survival of Escherichia coli. Appl Environ Microbiol. 2010 Dec;76(24):7925-30. 7. Boldyrev AA, Aldini G, Derave W. Physiology and pathophysiology of carnosine. Physiol Rev. 2013 Oct;93(4):1803-45.8. Kyriazis M. Low dose L-carnosine. Antiaging Bull 2001, 4(11):19-249. Liao JH, Lin IL, Huang KF, Kuo PT, Wu SH, Wu TH. Carnosine ameliorates lens protein turbidity formations by inhibiting calpain proteolysis and ultraviolet C-induced degradation. J Agric Food Chem. 2014;62(25):5932-810. Zhang T, Hu X, Cai Y, Yi B, Wen Z. Metformin protects against hyperglycemia-induced cardiomyocytes injury by inhibiting the expressions of receptor for advanced glycation end products and high mobility group box 1 protein. Mol Biol Rep. 2014 Mar;41(3):1335-4011. Kender Z, Fleming T, Kopf S, et al. Effect of metformin on methylglyoxal metabolism in patients with type 2 diabe-tes. Exp Clin Endocrinol Diabetes. 2014 May;122(5):316-912. Chang PC, Tsai SC, Jheng YH, Lin YF, Chen CC. Soft-tissue wound healing by anti-advanced glycation end-prod-ucts agents. J Dent Res. 2014 Apr;93(4):388-93. doi: 10.1177/0022034514523785. Epub 2014 Feb 19).13. Upadhyay A, Tuenter E, Ahmad R, Amin A, Exarchou V, Apers S, Hermans N, Pieters L. Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors. Planta Med. 2014 Aug;80(12):1001-8. doi: 10.1055/s-0034-1382949. Epub 2014 Aug 6)14. Kim J, Kim CS, Sohn E, Lee YM, Jo K, Shin SD, Kim JS. Aminoguanidine protects against apoptosis of retinal ganglion cells in Zucker diabetic fatty rats. Eur Rev Med Pharmacol Sci. 2014 Jun;18(11):1573-8).15. Elbe H, Vardı N, Orman D, Taşlıdere E, Yıldız. A Ameliorative effects of aminoguanidine on rat aorta in Strep-tozotocin-induced diabetes and evaluation of α-SMA expression. Anadolu Kardiyol Derg. 2014 Feb 14. doi: 10.5152/akd.2014.5047. [Epub ahead of print]).16. Farghaly HS, Thabit RH. L-Arginine and aminoguanidine reduce colonic damage of acetic acid-induced colitis in rats: potential modulation of NF-κB / p65. Clin Exp Pharmacol Physiol. 2014 Sep 15. doi: 10.1111/1440-1681.12287. [Epub ahead of print]). 17. Ahmad S et al. Glycoxidation of biological macromolecules: A critical approach to halt the menace of glycation. Glycobiology. 2014 Nov;24(11):979-90. doi: 10.1093/glycob/cwu057. Epub 2014 Jun 19).18. Tsunosue M, et al. An alpha-glucosidase inhibitor, acarbose treatment decreases serum levels of glyceraldehyde-de-rived advanced glycation end products (AGEs) in patients with type 2 diabetes. Clin Exp Med. 2010 Jun;10(2):139-41.19. Zhang J, Slevin M, Duraisamy Y, Gaffney J, A Smith C, Ahmed N. Comparison of protective effects of aspirin, D-penicillamine and vitamin E against high glucose-mediated toxicity in cultured endothelial cells. Biochim Biophys Acta. 2006 May;1762(5):551-7. Epub 2006 Mar 20.20. Garg S, Syngle A, Vohra K. Efficacy and tolerability of advanced glycation end-products inhibitor in osteoarthritis: a randomized, double-blind, placebo-controlled study. Clin J Pain. 2013 Aug;29(8):717-24.21. Zhang B, et al. Alagebrium (ALT-711) improves the anti-hypertensive efficacy of nifedipine in diabetic-hypertensive rats. Hypertens Res. 2014 Oct;37(10):901-7. 22. Khalifah, R.G., Baynes, J.W., and Hudson, B.G. Amadorins: Novel post-Amadori inhibitors of Advanced Glycation Reactions. Biochem and Biophys Res Comm, 1999, 257, 251-258.


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13

5-HTP the natural SSRI alternativeBy James South, MA

5-HTP (otherwise known as 5-hydroxy-tryptophan or oxitriptan), is the less well known cousin of serotonin (5-HT), one of the most important brain neurotransmitters.5HTP vs. tryptophanThe amino acid L-tryptophan found within our diet is first converted to 5-HTP inside the body by nerve cells via a vitamin B3 dependant enzyme and then 5-HTP is converted to 5-HT by a vitamin B6 dependant

enzyme. Yet now, thanks to modern science, we can take preformed 5-HTP, with its many consequent advantages.

5-HTP passes through the blood brain barrier into the brain far more easily than tryptophan and getting tryptophan through the blood brain barrier is the main bottleneck, which in many people leads to inadequate brain serotonin levels. Also, 5-HTP is not used to make proteins in the body, while tryptophan is, so there isn’t competition by cells outside the brain


for 5-HTP, as there is for the body’s scare tryptophan supplies.

The body often uses tryptophan to make vitamin B3, at a very high cost of 60 mg L-tryptophan to make just 1 mg of B3! However, 5-HTP is not wasted in this way to make vitamin B3.

L-tryptophan can be broken down in the liver by pyrrolase, an enzyme that converts tryptophan to kynurenine and its metabolites, which can be mildly liver toxic at high levels. But, 5-HTP is not metabolized through this pathway.

Because of this, L-tryptophan supplementation especially in chronically stressed people should be kept to 1 gram (1000 mg) per day or less, because the stress hormone- cortisol activates pyrrolase.

Serotonin and moodThe work of HM van Praag, SN Young and others over the last 20 years, shows that serotonin is a key brain neurotransmitter involved in mood regulation (anti-anxiety and anti-depression), impulse control, (it inhibits aggression and obsessive compulsive disorders [OCD] and pain). Serotonin is also the precursor for our pineal gland’s production of melatonin.

Human clinical studies show that 5-HTP is a far more efficient increaser of brain serotonin than L-tryptophan. Furthermore, when 5-HTP has been compared to tryptophan in human studies, 5-HTP has been a far more successful antidepressant, even when the tryptophan dosage used is 10 to 15 times higher than the 5-HTP dosage. Also, relapses back into depression are more common with tryptophan than with 5-HTP.

Unlike tryptophan, 5-HTP has also been shown to increase brain dopamine and noradrenaline activity. These are two key mood and alertness regulating neurotransmitters and when tyrosine, the amino-acid

precursor for brain dopamine/ noradrenaline is given along with 5-HTP, the effect is even more powerful.

5HTP vs. SSRI’sIn a society that has made the serotonin-selective re-uptake inhibitor (SSRI) drugs such as Prozac® the gold standard of managing the serotonin-deficiency syndrome, (note: even though the Poeldinger study showed 5-HTP to be superior to it), it is worth noting that a study reported by Risch and Nemeroff demonstrates, that even those successfully treated with SSRIs (ignoring their frequent and sometimes serious side effects), are still dependent upon their brains’ producing adequate serotonin from either tryptophan or 5-HTP.

SSRIs vs 5-HTPSSRIs work by conserving existing brain serotonin supplies by keeping more serotonin in the synaptic gap between neurons. They achieve this through preventing enzymatic degradation of synaptic serotonin. SSRIs do not enhance serotonin production. Risch and Nemeroff state; “...depressed patients were treated with low-tryptophan diets that were supplemented with high doses of neutral amino acids [which compete with tryptophan for transport through the blood-brain barrier]... Remitted depressed subjects receiving serotonergic antidepressants (e.g. fluoxetine [Prozac®], fluvoxamine) who were challenged with low-tryptophan diet supplemented with neutral amino acids promptly relapsed into severe clinical depression. When the tryptophan supplementation was provided, the patients promptly recovered...”

The many successful published studies using 5-HTP show that 5-HTP, by naturally elevating brain serotonin, can alleviate the serotonin-deficiency syndrome without any help from SSRI drugs. Yet the study related by Risch and Nemeroff eloquently shows that the success of SSRI drugs is crucially dependent upon the brain producing adequate serotonin, (from either tryptophan or 5-HTP) and that brain serotonin production is the controlling or rate-limiting variable underlying the apparent success of SSRIs.

It appears that the more logical and economically sound choice to alleviate conditions that result from the serotonin deficiency syndrome is 5-HTP, the


“Human clinical studies show that 5-HTP is a far more efficient increaser of brain serotonin than L-tryptophan.”


immediate precursor of the deficient substance.

ConclusionVan Praag’s and Young’s work suggests that 5-HTP is more likely to be effective for those suffering an anxious, agitated, aggressive, irritable depression and is rarely effective for those suffering from a severe, vegetative, total “blahs” type depression.

5-HTP may also be helpful in some cases of compulsive carbohydrate overeating, alcohol addiction and compulsive gambling (specific forms of OCD), as well as for insomnia.

Side effects of 5-HTP are occasional gastrointestinal upset, hypomania and euphoria, but whilst 5-HTP is a natural substance normally made by the brain, without medical supervision prudence suggests limiting daily dosage to 100 mg to 200 mg; the dose shown to be effective in human clinical studies.

Research also shows that both tryptophan and even more so 5-HTP, increase the activity of MAO inhibitor drugs, tricyclic antidepressants and selective serotonin inhibitor (SSRI) drugs, such as Prozac®, Paxil® and Zoloft®. Therefore L-tryptophan and especially 5-HTP should only be used by anyone taking any of these drugs ONLY under their prescribing physician’s consent and supervision.

References1. K. Zmilacher, et al. L-5-Hydroxytryptophan Alone and in Combination with a Peripheral Decarboxylase Inhibitor in the Treatment of Depression. Neuropsychobiology. 1988; 20: 28-35.

2. W. Byerley, et al. 5-Hydroxytryptophan: A Review of Its Antidepressant Efficacy and Adverse Effects. J Clin Psychopharmacol 1987; 7: 127-37.

3. S. Risch and C. Nemeroff. Neurochemical Alterations of Serotonergic Neuronal Systems in Depression. J Clin Psychiatry. 1992; 53: 3-7.

4. W. Poeldinger, et al. A Functional-Dimensional Approach to Depression: Serotonin Deficiency as a Target Syndrome in a Comparison of 5

-Hydroxytryptophan and Fluvoxamine. Psychopathology. 1991; 24: 53-81.

5. H. van Praag. Management of Depression with Serotonin Precursors. Biol Psychiatry. 1981; 16: 291-310.

6. S Takahashi, et al. Effect of L-5-Hydroxytryptophan on Brain Monoamine Metabolism and Evaluation of Its Clinical Effect in Depressed Patients. Psychiat Res 1975; 12: 177-87.

7. R. Kahn and H. Westenberg. L-5-Hydroxytryptophan in the Treatment of Anxiety Disorders. J Affect Disord, 1985; 8: 197-200.

8. V. Linnoila and M. Virkkunen. Aggression, Suicidality, and Serotonin. J Clin Psychiatry. 1992; 53: 46-51.

9. L. Buydens-Branchey, et al. Age of Alcoholism Onset. II. Relationship to Susceptibility to Serotonin Precursor Availability. Arch Gen Psychiatry. 1989; 46: 231-36.

10. J. Wurtman. Carbohydrate Craving, Mood Changes and Obesity. J Clin Psychiatry. 1988; 49: 37-39.

11. C. Cangiano, et al. Eating Behavior and Adherence to Dietary Prescriptions in Obese Adult Subjects Treated with 5-Hydroxytryptophan. Am J Clin Nutr 1992; 56: 863-7.

12. D. Murphy et al. Obsessive-Compulsive Disorder as a 5-HT Sub-sytem -Related Behavioural Disorder. Bri J Psychiatry. 1989; 155: 15-24.

13. C. Maurizi. The Therapeutic Potential for Tryptophan and Melatonin: Possible Roles in Depression, Sleep, Alzheimer’s Disease and Abnormal Aging. Med Hypoth. 1990; 31: 233-42.

14. G. DeBenedittis and R. Massei. 5-HT Precursors in Migraine Prophy laxis: A Double-Blind Cross-Over Study with L-5-Hydroxytryptophan versus Placebo. Clin J Pain. 1986; 3: 123-29.

15. J. Robertson and T. Monte. Natural Prozac Learning to Release Your Body’s Own Anti-Depressants. San Francisco: Harper; 1997.

16. Gaby. B6The Natural Healer. New Canaan: Keats: 1984.

17. H. van Praag. Studies of the Mechanism of Action of Serotonin Precursors in Depression. Psychopharmacol Bull. 1984; 20: 599-602.

18. P. Hartvig et al. Pyridoxine Effect on Synthesis Rate of Serotonin in the Monkey Brain Measured with Positron Emission Tomography. J Neural Trans. 1995; 102: 91-7.

19. K. Dakshinamurti, et al. Influence of B Vitamins on Binding Properties of Serotonin Receptors in CNS of Rats. Klin Wochenschr. 1990; 68: 142-45.

20. M. Jacobsen, et al. Cardiac Manifestations in Mid-gut Carcinoid Disease. Eur Heart J. 1995; 16: 263-68.

21. Y. Hoshino, et al. Serum Serotonin Levels of Normal Subjects in Physiological State and Stress Conditions. Jpn J Psychosom Med. 1979; 19: 283-93.

22. H. van Praag. Central Monoamine Metabolism in Depressions. I. Serotonin and Related Compounds. Compreh Psychiatry. 1980; 21: 30-43.

23. T. Li Kam Wa, et al. Blood and Urine 5-Hydroxytryptamine [Serotonin] Levels after Administration of Two 5-Hydroxytryptophan Precursors in Normal Man. Bri J Clin Pharmacol. 1995; 39:327-29.

24. G. Huether, et al. The Metabolic Fate of Infused L-Tryptophan in Men: Possible Clinical Implications of the Accumulation of Circulating Tryptophan and Tryptophan Metabolites. Psychopharmacol (Germany). 1992; 109: 442-32.

25. K. Tornebrandt, et al. Heart Involvement in Metastatic Carcinoid Disease. Clin Cardiol. 1986; 9 (1).

26. R. Arora and R. Warner. Do Indole Markers Predict Carcinoid Heart Disease? Chest. 1986; 90: 87-9.

27. M. Werbach. Nutritional Influences on Illness, 2nd ed. Atherosclerosis, 57-102. Tarzana, CA: Third Line Press; 1996.

28. P. Turlapaty and B. Altura. Magnesium Deficiency Produces Spasms of Coronary Arteries: Relationship to Etiology of Sudden Death Ischemic Heart Disease. Science. 1980; 208: 198-200.

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Dr Ward Dean answers your questions

We are delighted that Ward Dean, M.D., one of the world’s foremost antiaging physicians, has agreed to answer our readers’ questions. Full details about Dr. Dean can be seen at his website: www.warddeanmd.com

Dear Dr. Dean,

Q. I am 46 years of age. In 2009, I developed dia-betes insipidus. I had an inflammation on my pitu-itary gland and as a result I started drinking lots of very cold water with ice. I gained over 20 kg in a few months. I am continuing to experience weight gain, can’t control my weight and I still wake up in the night and drink lots of water, ½ liter at a time. I feel depressed and I don’t sweat. My endocrinolo-gist gave me thyroxin for my thyroid. I feel better, but I’m not 100% as I once was. What supplements would you recommend for me? Looking forward to hearing from you.

I.C., Australia

A. Dear Mrs. I.C., Diabetes insipidus is indeed due to pituitary dysfunction, specifically to a loss of anti-diuretic hormone produced by the posterior pituitary for whatever reason. Often, it can result following delivery of a baby. For those not familiar with the condition, diabetes insipidus is similar to someone who urinates excessively after drinking alcohol, (because alcohol inhibits the production of anti-diuretic hormone). Of course, with alcohol use, the condition is self-limited by discontinuing alcohol ingestion. Unfortunately, in your case, the pituitary isn’t doing its job, for some reason. Therapeutically, I suggest you add vasopressin (or desmopressin) to your daily regimen, once or

twice per day, as needed. For convenience, I suggest especially at bedtime, to help you sleep without bathroom interruptions.Second, I’m sure your endocrinologist is adjusting your dose of thyroid based on your blood tests, rather than how you are really doing. I believe that thyroid blood tests are usually a waste of blood—and that the dose of thyroid replacement should be based on how the patient is doing, and whether the thyroid-related spectrum of symptoms are resolving, while monitoring the heart rate and body temperature, as described by Dr. Rick Wilkinson, in his article, The Epidemic of Low Thyroid Diseases, in Aging Matters™ Magazine, issue # 4, 2014.1I generally use Armour® or one of the other natural forms of thyroid, instead of thyroxine (T4, the inactive form of thyroid hormone, must be de-iodinated to T3 to become active). Titrate the dose upwards, progressively over weeks to months, until you arrive at a dose with which you are comfortable, and relatively symptom-free, with a normal (65-75 beats/minute) heart rate and normal temperature. If your thyroid hormone level is inadequate, you will have an extremely difficult time trying to normalize your weight. Also, depression is a hallmark of hypothyroidism and is one of the first symptoms to be relieved with appropriate doses of thyroid. I also suggest metformin, 500 mg three times per

day. If you have read much of my material, based on the works of Prof. Vladimir Dilman, you will know that metformin is a “metabolic rejuvenator,” that restores hypothalamic (and pituitary) receptor sensitivity to insulin, cortisol, and other hormones. Metformin is an integral component of the weight loss program that I implement in my clinic. Metformin normalizes insulin and enhances its effectiveness, generally resulting in significant weight loss in my overweight patients.

Another component that I often recommend is acarbose. Acarbose is an alpha-glucosidase inhibitor—in layman’s language, it is a starch blocker—i.e., it blocks the conversion of complex carbohydrates into glucose and delays their absorption, resulting in overall reduced glucose spikes, and reduced caloric absorption. When used with metformin, acarbose greatly enhances weight loss. I recommend 100 mg three times per day, with meals (or carbohydrate-laden snacks), make sure you chew the tablets not swallow them.I believe that with the combination of vasopressin (to assist your pituitary), increasing your dose of thyroid, and adding Metformin and Acarbose to your regimen will greatly alleviate your thirst and excessive diuresis, weight gain and depression.In addition, I have been reliably informed that the Russian peptide bioregulator for the bladder, called Chitomur® is a useful adjunct to reduce urination. I don’t have personal experience of this yet, but considering the safety profile of these peptides could well be worth a try.Let me know how you do, Ward Dean, M.D.

[Editor- IAS provides acarbose as 100 mg tablets branded Glucobay®, metformin is available from IAS as Metforal® 500 mg tablets and also in SR (slow release) tablets; vasopressin is available in nasal spray as Vaso-Pro™ and desmopressin is available as a nasal spray as Minurin®].

1. Wilkinson, R. The Epidemic of Low Thyroid Diseases, Aging Matters Magazine, No5, 2014 # 4-9.2. Standl, E, and Schnell, O. Alpha-glucosidase inhibitors 2012- Cardiovascular considerations and trial evaluation. Diabetes & Vascular Diseases Research, 2012; 9:(3) 163-169.

Q. I’ve read a lot of your stuff over the years and know that you’re a big fan of niacin (Vitamin B3, nicotinic acid) for normalizing blood lipids. What are your thoughts regarding the recent study in the New England Journal of Medicine, which disparaged the lipid-lowering benefits of niacin and implied that it was actually toxic?

J.E., California

A. Dear Mr. J.E., Thanks for giving me the opportunity to respond to this issue. The study in question was not a study of niacin, per se. It was actually a study comparing the addition of extended-release niacin plus laropiprant, (an antihistamine which purportedly reduced niacin-induced flushing) to patients who were already taking simvastatin 40 mg per day, or simvastatin plus ezetimibe 10 mg per day, (ezetimibe is a drug that is designed to increase HDL). (1)I was really surprised to note that it wasn’t just a single article warning against niacin. The same issue of the New England Journal coincidentally had a Letter to the Editor, questioning the “Safety Profile of Extended-Release Niacin in the AIM-HIGH Trial,” (2) and an Editorial, “Niacin and HDL Cholesterol—Time to Face Facts” (3)—i.e., a triple take-out piece!

Figure 1: Life extending effect of niacin. 16 year mortality data on men in the Coronary Drug Project, showing that those on nicotinic acid lived about two years longer than those on placebo.

HDL-C With IR Niacin

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The study involved 25,637 high-risk patients from 245 test sites in the UK, Scandinavia, and China. The “placebo” group received Simvastatin 40 mg or Simvastatin 40 mg plus Ezetimibe 10 mg, plus a 50 mg low-dose niacin-containing “placebo.” The “niacin” group received 2,000 mg of extended-release niacin and 40 mg of Laropiprant, in addition to the Simvastatin or Simvastatin plus Ezetimibe, as was given to the placebo group. The participants in the study were followed for a median of nearly four years. The study was stopped prematurely after three years because of an apparent lack of benefit with extended-release niacin (plus laropiprant).The authors concluded that the Niacin-Laropiprant combination; “did not significantly reduce the risk of major vascular events, but did significantly increase the risk of serious adverse harm,” and alleged that, “the study identified significant hazards, some of which had not been reported previously with niacin.”Let’s digress. The cholesterol-lowering effects of nicotinic acid were first reported in 1955.(4) The clinical benefits of immediate-release nicotinic acid were best demonstrated in the Coronary Drug Project (CDP), which compared immediate-release niacin with other cholesterol-lowering regimens on cardiovascular end points.(5) In the CDP, immediate-release niacin reduced the total cholesterol level by 26 mg/dl (from a high baseline level of 253 mg/dl) and after six years, reduced the incidence of non-fatal MI (heart attacks) by 26% and cerebrovascular events (strokes) by 24%. Moreover, 9 years after trial termination, the group treated with niacin had 11% fewer deaths than the placebo group (Fig. 1). (5) Although lipid fractions were not measured in the CDP, subsequent studies with immediate-release niacin showed that it reduces LDL up to 25%, triglycerides up to 50% and Lp(a) up to 35%; and increases HDL up to 35%. (6-8)The most commonly reported side effect of immediate-release niacin are the well-known flushing and itching of the skin, (cutaneous vasodilation) that can be so uncomfortable that it may cause some people to discontinue taking it. Although the flushing can be overcome by taking niacin at the end of a meal, or by taking an aspirin 30 minutes prior to taking niacin, it is also self-limited and tolerance to flushing develops with continued use. Nevertheless, pharmaceutical companies

developed timed-release preparations to minimize or eliminate this effect. Unfortunately, timed-release niacin is less effective (and more toxic) than immediate release, cheap, over-the-counter niacin (Fig. 2).

Figure 2: Low doses of plain (immediate-release) nicotinic acid have more favorable effects than timed-release forms on serum triglyceride and high-density (HDL) cholesterol concentrations, although they are both equally effective on LDL. The majority of the effects on triglycer-ides and HDL occur with lower doses (less than 2,000 mg).

Years of Follow-Up2 4 6 8 10 12 14 16

70605040302010

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ityNow back to the New England Journal study. The “serious adverse harm” included “diabetes-related, gastrointestinal, musculoskeletal and skin-related disorders,” which the authors stated were previously known to be caused by niacin. Additionally, the authors stated that most of the serious musculoskeletal adverse events with niacin-laropiprant were due to myopathy, (muscle weakness, pain and atrophy); and there was an unexpected finding of excess serious infection and serious bleeding events. The authors further claimed that “niacin alone” was also associated with a significant increase in the risk of serious infection in a previous study as well (AIM-HIGH10). (1)The AIM-HIGH study, 10 however, was not a study of “niacin alone”—it was a study that also combined extended-release niacin with intensive statin therapy. With regard to the excess bleeding, the authors conceded that it may not have been due to niacin—but may have been due to laropiprant – as several potential mechanisms for bleeding have been previously proposed for laropiprant, (11,12) and niacin has not previously been reported to cause bleeding problems. The authors of the New England Journal study curiously overlooked the fact that the FDA in 2012 required that labels on statin drugs be changed to include information concerning statin-induced glycemic effects, diabetes and increases in


hemoglobin A1C or fasting plasma glucose. (13) This label change was based on several meta-analyses that demonstrated the relationship between statin use and diabetes. One meta-analysis examined the effect of statins on the risk of diabetes in 91, 140 patients from 13 trials, which showed that statins were associated with a 9% increased risk of diabetes. (14) Another meta-analysis of 32,752 patients, in five trials, found that higher potency statins were associated with a 12% increased risk of diabetes, compared to low potency statins. (15) Simvastatin, at a dose of 40 mg (as used in the New England Journal study), was considered to be a high potency statin. (16)Although immediate-release niacin may cause reductions in glucose tolerance when treatment is initially begun, studies show that glucose generally returns to pre-treatment levels with continued use (17, 18)- (Fig. 3). On the other hand, the package insert for extended-release niacin, (as used in the New England Journal study) cautions that “NIASPAN can cause an increase in blood sugar levels.” It is thus likely that the combination of simvastatin and extended-release niacin in the New England Journal study caused the increased incidence of diabetic changes.Timed-release niacin also tends to be more hepatotoxic than immediate-release niacin, causing significant increases in liver enzymes and multiple reports of hepatic failure. (19,20) One report, which illustrated the comparative safety of immediate-release niacin involved three patients who incurred hepatitis from timed-release niacin, who were later re-challenged with immediate-release niacin with no evidence of hepato-cellular injury due to the immediate release niacin. (21)

Statins are known to cause myalgias, fatigue and rhabdomyolysis. These effects may be worsened by combining statins with niacin. Most of the excess musculoskeletal adverse events in the New England

Journal report were due to myopathy and the absolute excess of myopathy associated with adding niacin-laropiprant to the statin-ezetimibe therapy was more than 10 times as great among participants in China as those in Europe. (1) This should not have been surprising. The Zocor/Simvastatin package insert warns: “Cases of myopathy/rhabdomyolysis have been observed with simvastatin co-administered with lipid-modifying doses (more than 1 g/day) of niacin-containing products. In particular, caution should be used when treating Chinese patients with simvastatin doses exceeding 20 mg/day co-administered with lipid-modifying doses of niacin-containing products.”

Time, wkBaseline 0 6 12 18 24 36

200

Placebo With DiabetesNiacin Without Diabetes

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160

140

120

100

80

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Fasti

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Figure 3: Effect of immediate-release niacin on fasting glucose in participants with and without diabetes. Niacin was associated with a transient increase in glucose, which largely returned to baseline with continued use.

The New England Journal study concluded that “treatment with extended-release niacin-laropiprant did not significantly reduce the risk of major vascular events but did significantly increase the risk of serious adverse events.” (1)The highly-publicized New England Journal article was thus not a true study of the clinical efficacy of over-the-counter immediate-release niacin. It was, instead, a testament that it’s probably not a good idea to combine extended-release niacin with a pharmaceutical hodge-podge of a high potency statins, ezetimibe and latanoprost.

“Statins are known to cause myalgias, fatigue and rhabdomyolysis. These effects may be worsened by combining statins with niacin.”


I’d like to see a head-to-head 3-arm study comparing the efficacy and side-effects of (1) immediate release niacin, (2) a statin and (3) a statin plus niacin. Until such a study is conducted, I will continue to use (and recommend to my patients) immediate-release niacin—which I believe to be the safest, cheapest, most effective lipid-lowering substance available.Ward Dean, M.D.1. Landray, MJ, Haynes, R, Hopewell, J., et al. Effect of Ex-tended-Release Niacin with Laropiprant in High-Risk Patients. NEJM, 2014, 371;3, 203-212.

2. Anderson, TJ, Boden, WE, Desvigne-Nickens, P, et al. Safe-ty Profile of Extended-Release Niacin in the AIM HIGH Trial. NEJM, 2014, 371;3, 288-290.

3. Lloyd-Jones, DM. Niacin and HDL Cholesterol—Time to Face Facts. NEJM, 2014, 371;3, 271-273.

4. Altschul, R, Hoffer, A, Stephen, JD. Influence of nicotinic acid on serum cholesterol in man. Arch Biochem biophys 1955; 54:558-9.

5. Canner, PL, Berge, KG, Wenger, NK, et al. Fifteen year mor-tality in Coronary Drug Project patients: Long term benefit with niacin. J Am Coll Cardiology 1986;8:1245-1255.

6. Miller, M. Niacin as a component of combination therapy for dyslipidemia. Mayo Clin Proceedings 2003;78:735-742.

7. Illingworth, DR, Stein, EA, Mitchel, YB, et al. Comparative effects of Lovastatin and Niacin in primary hypercholesterolemia. Arch Intern Med 1994; 154:1586-1595.

8. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High lood Cholesterol in Adults. Third report of the National Cholesterol Ed-ucation Program (NCEP) Expert Panel on Detection, Evaluation and Treatment of High Blood Cholesterol in Adults: Final report. Circulation 2002;106:3143-3421.

9. Knopp, RH. Drug treatment of lipid disorders. NEJM 1999;341:498-511.

10. The AIM-HIGH Investigators. Niacin in patients with low HDL cholesterol levels receiving intensive statin therapy. NEJM 2011; 365:2255-67.

11. Lai, E, Schwartz, JI, Dallob, A, et al. Effects of extended release niacin/laropiprant, laropiprant, extended release niacin and placebo on platelet aggregation and bleeding time in healthy subjects. Platelets 2010; 21:191-8.

12. Dallob, A, Luo, WL, Luk, JM, et al. The effects of laropiprant, a selective prostaglandin D2 receptor antagonist, on the antiplate-let activity of clopidogrel or aspirin. Platelets 2011;22:495-503.

13. Food and Drug Administration. FDA drug safety communica-tion: important safety label changes to cholesterol-lowering statin drugs. 2012. www.fda.gov/drugs/drugsafety/ucm293101.htm

14. Sattar. M, Preiss, D, Murray, HM, et al. Statins and risk of diabetes; a collaborative meta-analysis of randomized statin trials. Lancet 2010;375:735-42.

15. Preiss, D, Seshasai, SR, Welsh, P, et al. Risk of diabetes with intensive-dose compared with moderate-dose statin therapy. JAMA 2011;305:2556-64.

16. Dormuth, CR, Filion, KB, Peterson, JM, et al. Higher poten-cy statins and the risk of new diabetes: Multicenter, observational study of administrative databases. BMJ 2014; 348:g3244.

17. Elam, MB, Hunninghake, DB, Davis, KB, et al. Effect of nia-cin on lipid and lipoprotein levels and glycemic control in patients with diabetes and peripheral arterial disease. The ADMIT Study: A randomized trial. JAMA 2000;284:1263-1270.

18. Grundy, SM, Vega, GL, McGovern, ME, et al. Efficacy, safety, and tolerability of once-daily niacin for the treatment of dyslipidemia associated with type 2 diabetes. Arch Int Med 2002; 162:1568-1576.

19. McKenney, JM, Proctor, JD, Harris, S. A comparison of the efficacy and toxic effects of sustained- vs immediate-release niacin in hypercholesterolemic patients. JAMA 1994;271:672-677.

20. Mullin, GE, Greenson, JK, and Mitchell, NC. Fulminant hepatic failure after ingestion of sustained-release nicotinic acid. Ann Intern Med 1989;76:239-241.

21. Henkin, Y, Johnson, KIC, and Segrest, JP. Rechallenge with crystalline niacin after drug-induced hepatitis from sustained-re-lease niacin. JAMA 1990; 264; 241-243.

22. NIASPAN package insert, Revised: 04/2014

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'U��.\ULD]LV�ERRN��µWKH�FDWDUDFW�FXUH¶��details the usefulness and evidence of Can-C eye-drops.

Now available from IAS as a FREE e-book: KWWS��ZZZ�DQWLDJLQJ�V\VWHPV�FRP�FDQ�F�HERRN

“I am so grateful for the development of Can-C eye-drops, not only have WKH\�VLJQL¿FDQWO\�LPSURYHG�P\�RZQ�eyesight, but many of my patients report most favorably about them too. Now we have a real alternative to eye surgery so Can-C can be considered to be a genuine breakthrough.” Richard Lippman, Ph.D.

Can-C Plus tablets are specially designed to be used alongside the Can-C™ eye-drops to aid and even boost their effectiveness. As there are a few supplements that can block the action of Can-C eye-drops, Can-C Plus tablets have been carefully designed to avoid them. Three Can-C Plus tablets a day can be taken with food, with or without Can-C eye-drops, DOWKRXJK�IRU�PD[LPXP�EHQH¿W�LW�LV�UHFRPPHQGHG�WKDW�WKH\�DUH�used together.

Can-C Plus™


Like all good antiaging supplements, centrophenoxine has many useful features with few side effects. From a memory and cognition viewpoint, centrophenoxine has GHPRQVWUDWHG�VLJQL¿FDQW�LPSURYHPHQWV��PRVW�notably its ability to speed up the process of memory recall.

One of centrophenoxine’s most noted EHQH¿WV�LV�LWV�DELOLW\�WR�HIIHFWLYHO\�DQG�TXLFNO\�UHPRYH�D�FHOO�WR[LQ�WKDW�DFFXPXODWHV�ZLWK�DJH��DQG�$O]KHLPHU¶V�GLVHDVH��called lipofuscin. Lipofuscin can make up parts of the so-FDOOHG�$O]KHLPHU�EUDLQ�SODTXHV��EXW�LW�FDQ�HYHQ�EH�IRXQG�LQ�WKH�brains of ‘normal’ aging people as well as other organs such as the heart, the lungs and even the skin- where it forms part RI�WKH�VR�FDOOHG�DJH�RU�OLYHU�VSRWV��WKH�EURZQ�ÀHFNV�IRXQG�LQ�‘aged’ person’s skin. Indeed several weeks of centrophenoxine supplementation has seen removal and lightening of such spots.

Centrophenoxine (Centro-Pro™)

“Centrophenoxine has shown many facets to improve conditions related to my membrane hypothesis of aging, for example its ability to improve brain-performance, survival time in animal experiments, and to remove the cell aging-pigment called lipofuscin. It has been my antiaging supplement for more than ��\HDUV�´�Professor Imre Zs.-Nagy

CoQ10 is a universal energy agent WKDW�KDV�VLJQL¿FDQW�SURWHFWLYH�TXDOLWLHV�for the heart and the cardiovascular system. An important point- anyone taking a statin drug to lower cholesterol must also be taking CoQ10 since statins lower CoQ10 levels.

UPDATE: Our CoQ10SR™ is a slow release version combined with cyclodextrin, a new technology that enables greater bioavailability by improving the passage through the stomach into the blood. It has been clinically shown that CoQ10SR™ has up to twice the bioavailability of ‘regular’ CoQ10. Thus depending on how you look at it, CoQ10SR is either double the effectiveness of CoQ10’s of the same dose, or half the price of CoQ10’s of twice the dose!

CoQ10 (coenzyme Q10)

By harnessing the power of the natural healer, curcumin, (found in turmeric) we have access to a wide-ranging set of positives. From bolstering the immune system, to moderating LQÀDPPDWRU\�UHVSRQVHV��LW�FDQ�DOVR�DFW�DV�DQ�DQWL�YLUDO�DQG�DQ�anti-fungal agent. It’s even been found to have the ability to

counter many conditions including a very recent study as an anti-depressive.

UPDATE: Our CurcuminSR™ is a unique slow release version that is much more bioavailable than regular versions.

Curcumin™

The experiments of Professor -R]HSK�.QROO�GUDPDWLFDOO\�extended the lifespan of rats who were given deprenyl. (YHQ�WKH�¿UVW�UDW�WR�GLH�WKDW�was treated with deprenyl died after the last rat not treated with deprenyl died.

This graph highlights the loss of dopamine with age, RQ�DYHUDJH��SHU�GHFDGH�past the age of 40 for the average person, but far greater for those suffering from Parkinson’s disease

Parkinson’s disease is characterised by the loss of the brain neurotransmitter dopamine. Deprenyl helps WR�SUHYHQW�WKLV�ORVV�E\�DFWLQJ�RQ�WKH�VSHFL¿F�HQ]\PH�0$2�E��3URIHVVRU�.QROO�DOVR�EHOLHYHV�WKDW�GHSUHQ\O�YHU\�VLJQL¿FDQWO\�LQFUHDVHV�3($��SKHQ\OHWK\ODPLQH��DQG�WKDW�WKLV�PD\�KDYH�DQ�HYHQ�PRUH�VLJQL¿FDQW�function than the MAO-b inhibition, (for more GHWDLOV�RQ�WKLV�SOHDVH�UHDG�3URIHVVRU�.QROO¶V�H[FHOOHQW�ERRN�RQ�the subject- ‘the brain and its self’).

Deprenyl (selegiline)

3URIHVVRU�-R]HSK�.QROO�RI�'HEUHFKHQ�University in Hungary- the inventor of deprenyl

In addition to improving dopamine levels, deprenyl has also been shown to help rebalance serotonin, noradrenaline and acetylcholine levels and whilst the uses remain ‘off-label’ GHSUHQ\O�KDV�EHHQ�XVHG�IRU�$O]KHLPHU¶V�DQG�HYHQ�FDQFHU�treatments.

Our focus here is upon deprenyl’s enhancement of dopamine, which is a key brain chemical responsible for drive, focus and well being and even libido (especially for men).


Technically it is the closest legal molecule to GHB. Its approved use in Europe is to help with epilepsy, but like GHB, GABOB has been shown to improve growth hormone release VLJQL¿FDQWO\�ZKHQ�WDNHQ�EHIRUH�EHGWLPH��GABOB does not have the ‘sleep inducing’ effects of GHB, but it can cause some sedation if taken in high doses.

Glutathione is a potent antioxidant that helps to prevent damage to important cellular components that can be caused by reactive oxygen species such as free radicals and peroxides. Glutathione is principally V\QWKHVL]HG�LQVLGH�WKH�ERG\�DQG�LV�UHODWLYHO\�poorly obtained via the diet. The Advanced Cellular Glutathione supplement is a spray SURYLGLQJ�QDQR�VL]HG�SDUWLFOHV�IRU�VXE�PXFRVDO�absorption to create instant bioavailability.

The idea behind the antiaging use of deprenyl is to use very small doses regularly in order to help maintain healthy dopamine levels and thus improve cognitive function and help to maintain function at a better level for much longer.

UPDATE: The Dep-Pro™ liquid can dispense selegiline HCL in small quantities as 1 drop = 1 mg.

Esnatri cream is the world’s only bio-identical estrogen cream to replicate the work of Dr. Jonathan Wright. Dr. Wright has highlighted that the ‘average’ woman produces estrogens in the ratios of estriol ��HVWUDGLRO��DQG�HVWURQH��DQG�these are the exact same ratios found inside Esnatri. Each 1ml of Esnatri cream provides 2mg in total of the triple estrogens and it enables a precise, natural and indeed bio-identical hormone replacement therapy for women concerned about the menopause. IAS provides dose and timing advice from Dr. Wright for both estrogens and progesterone with every purchase. The additional use of bioidentical progesterone should be used along with an estrogen replacement program. For further information on estrogens we recommend one of Dr. Thierry Hertoghe’s Hormone handbooks.

GHRP2 is growth hormone releasing peptide number 2. It is a potent releaser of HGH for fat loss and is particularly synergistic with sermorelin. It is best taken in the morning, by swallowing 4ml of the liquid. Up to 10ml may be used for shorter periods of time.

UPDATE: The work of Dr Richard :DONHU�KLJKOLJKWV�WKDW�*+53��LV�SDUWLFXODUO\�HIIHFWLYH��synergistic when combined with sermorelin.

Esnatri™ cream (bio-identical estrogens)

GHRP2

GABOB (Gamibetal®)

Glutathione (also see ACF228™ Breathe-Easy)


Hair-Pro is the very latest development to help induce hair growth. It contains the absolute latest cutting-edge growth factor technologies.

Hair Pro is a unique proprietary topical OLTXLG�EOHQG�WKDW�LQFOXGHV�¿QDVWHULGH��(the DHT blocking drug used orally for years as a hair loss treatment). It also contains a plethora of amino acids that act as hair growth factors including bFGF, TRX, VEGF and IGF-1. In addition there is aminosyn to promote protein synthesis (hair strength), hyaluronic acid to aid hair hydration (thickness) and dexpanthenol to cleanse the pores of the blocking fat- sebum which can block nutrition from the hair root. It’s a unique and potent formula to battle alopecia.

UPDATE: Use it in combination with the Scalproller to improve uptake into the scalp.

Hair-Pro™

Hydergine (ergoloid mesylate)

Hydergine is an extract of a fungus that grows on rye called ergoloid mesylate. Its approved uses have been to aid persons ZLWK�PHPRU\�GLVWXUEDQFHV��$O]KHLPHU¶V�disease and even for persons who have suffered from electric shock, drowning or suffocation. This is because hydergine stabilises the levels of oxygen in the brain. It has been shown to improve oxygen levels when they are too low and decreases levels when they are too high. The result of this optimised oxygen availability in the brain is an ability to do more mental work without becoming tired. Accordingly, hydergine can be a good tool to battle

This graph highlights that Professor Pierpaoli’s Melatonin Zn Se formula mimics the night peak of melatonin. Note that sublingual melatonin tested peaks too soon and that time released formulas peak too late.

+\GHUJLQH�DOVR�VWLPXODWHV�WKH�JURZWK�RI�GHQGULWH�QHUYH�¿EHUV��These connective strands are known to decline in aging. This is another antiaging feature of hydergine. Some have even linked WKH�GHQVLW\�DQG�QXPEHUV�RI�GHQGULWH�¿EHUV�WR�WKH�OHYHO�RI�,�4��In summary, hydergine helps to protect against conditions of hypoxia and peroxidation, important factors to guard against a stroke and generalised brain injuries. Hydergine can extend WKH�ERXQGDULHV�RI�PHQWDO�ZRUNORDG�DQG�HQHUJ\��¿JKWLQJ�DJDLQVW�boredom and may even provide some groundwork for raising the levels of intelligence.

The Bertonin-Freddari et al, 1994 study highlights that hydergine FDQ�LPSURYH�WKH�VL]H��volume and number of mitochondria in old animals- towards the youthful example; as is shown here the difference between young, old (without hydergine) and ROG��ZLWK�K\GHUJLQH��LV�VLJQL¿FDQW�

Melatonin (MZS™)

Melatonin is one of nature’s remarkable substances. It is made in response to darkness by the pineal JODQG��0HODWRQLQ¶V�EHQH¿WV�WR�KHOS�RYHUFRPH�MHW�ODJ�DQG�VKLIW�work have become quite well known and indeed it is useful for this purpose since adequate melatonin availability enables our bodies to be correctly in tune with our circadian rhythms. These circadian rhythms dictate our hormonal cyclicity and this cyclicity ultimately determines our aging and our level of immunity. Unfortunately melatonin secretions decline with aging. Professor Pierpaoli has published widely on melatonin, principally through the New York Academy of Science and at the meetings of the Stromboli conferences on aging and cancer- which IAS is delighted to support. What is important to know about melatonin is that Professor Pierpaoli advocates a �PJ�GRVH�WR��KLV�ZRUGV��³SXW�WKH�SLQHDO�WR�VOHHS�´�,Q�DGGLWLRQ��it is also vital to use a melatonin that produces a night peak of melatonin that is the same as the peak produced by the pineal LWVHOI��7KXV�KH�KDV�DFKLHYHG�XVLQJ�VSHFL¿F�H[FLSLHQWV�LQ�KLV�own formula ‘MZS™’ (which also contains the additional V\QHUJLVWLF�LQJUHGLHQWV�RI�]LQF�DQG�VHOHQLXP��

For further detailed information about melatonin and Professor Pierpaoli’s work we recommend his book ‘the key of life,’ it is now available as a FREE e-book from the IAS website.

Here are some before and after Fundus photos showing the EHQH¿W�RI�0HODWRQLQ�Zn Se. They highlight dramatic improvements to both wet and dry forms of macular degeneration. In a trial published in the New York Academy of Science, 110 eyes, (100 patients) with both wet and dry forms of ARMD were treated only with 1 tablet of Melatonin Zn Se nightly. After ��PRQWKV��RI�WKH�WUHDWHG�SDWLHQWV¶�H\HV�KDG�VLJQL¿FDQW�improvements to their condition. This is simply remarkable compared to the current approved therapy for ARMD which involves injecting the eye quarterly, (costs $1000+) with 50% improvement at 24-months!


Minsaw™MinSaw has been updated numerous times, but now it’s in its best formula ever. MinSaw provides all of these proven hair growth and protectors in its latest formula:

• Minoxidil: Perhaps the best known agent to help stimulate hair growth, which it does by increasing nitric oxide promotion in the root of the hair. In doing so it delivers more nutrition for the hair to grow faster. MinSaw has the most potent amount of minoxidil at 8%.

• Vitamin C: Helps stimulate hair growth and ‘clean’ the root bulb. MinSaw contains the active form of L-ascorbic acid.

• Saw Palmetto: This herb helps to block the damaging effects of DHT, a known hair growth restrictor.

• Resveratrol: The remarkable protective agent found in red grape skins has recently been noted to help induce hair thickness.

• Melatonin: This has been documented and patented to help prevent hair loss.

• Retinolic acid (also known as tretinoin). This super high strength vitamin A improves skin condition by enhancing EORRG�ÀRZ�WR�WKH�VNLQ��,Q�WKH�VDPH�ZD\��WKLV�LQJUHGLHQW�

through boring paperwork or a long drive home in the dark. A fascinating animal experiment showed a special ability for hydergine to improve mitochondrial condition. The mitochondria are vital organelles found in every cell of our body responsible for the generation of ATP, the universal HQHUJ\�PROHFXOH��8QIRUWXQDWHO\�PLWRFKRQGULDO�HI¿FLHQF\�declines as we age. However, an Italian study highlighted that old animal mitochondria can be improved with hydergine supplementation.

The results of low dose naltrexone, (widely known as LDN) therapy have been remarkable. Originally, the use of naltrexone was in the management of dependence on opioid and alcohol. But it was Dr. Bernard Bihari in the 1980’s who ¿UVW�XVHG�ORZ�GRVH�QDOWUH[RQH�IRU�the treatment of HIV and then for a number of other autoimmune diseases such as multiple sclerosis, Crohn’s disease and many immunological related diseases. Many MS patients have reported an improved quality of life. A leading study has established that by maintaining regular nightly LDN, less than 1% of the MS sufferers experience fresh MS attacks. IAS supplies the LDN dose of 4.5 mg.

Naltrexone

MSH2-Pro™ MSH2 is the abbreviation for melanocyte stimu-lating hormone (type II). This hormone has a di-rect effect on tanning the skin and if used regular-ly will darken skin- even without exposure to the sun. In addition, MSH has been noted to enhance libido and suppress the desire to eat.

NOTE: MSH use should not exceed 2-sprays per day and must not be used by persons with hyper-tension, (high blood pressure).

Oxytocin is a hormone produced in the hypothalamus and secreted into the blood by the pituitary gland.

2[\WRFLQ�KDV�SDLQ�FXUELQJ�DELOLWLHV�DQG�FRXOG�EH�HI¿FDFLRXV�LQ�¿EURP\DOJLD��2WKHU�VWXGLHV�DUH�KLJKOLJKWLQJ�WKDW�R[\WRFLQ�

FRXOG�EH�HI¿FDFLRXV�LQ�WKH�WUHDWPHQW�RI�DXWLVP�DQG�HYHQ�VFKL]RSKUHQLDV��%XW�LW�LV�SHUKDSV�LWV�DELOLW\�WR�HQKDQFH�bonding between partners that is likely to attract most attention. Oxytocin increases ejaculate in the male and has VLJQL¿FDQW�OLELGR�HQKDQFHPHQW�HIIHFWV�LQ�IHPDOHV��LQFOXGLQJ�WKH�inducement of multiple orgasms. We have worked alongside 'U��+HUWRJKH�WR�FUHDWH�D�SUDFWLFDO�DQG�HI¿FDFLRXV�VXEOLQJXDO�trouche (a gel like tablet). Typical doses are 5 to 20 IU. (The square troches can be cut in half from corner to corner easily).

Oxytocin (Oxy-Pro™)

Oxytocin has been described in detail in Dr. Thierry Hertoghe’s latest book- Passion, Sex and Adventure, the oxytocin story.

UPDATE: Oxy-Pro™ is a new nasal spray version of oxytocin (delivering 10 IU per spray) in addition to our 20 IU sublingual trouches (Oxy-Sub™).

7KHVH�DUH�WKH�YHU\�ODWHVW�WHFKQRORJ\�IURP�3URIHVVRU�.KDYLQVRQ�LQ�5XVVLD��7KH\�XWLOLVH�KLJKO\�VSHFL¿F�SHSWLGHV�H[WUDFWHG�IURP�Danish bovine sources.

These peptides have been shown to be a short-cut to protein synthesis by activating directly with their receptive genes. Therefore their action is to ‘reinvigorate’ WKHLU�UHVSHFWLYH�JODQG��RUJDQ��WR�LQGXFH�their biological reserve and essentially rejuvenate their processes.

1.Bobothyrk® is the peptide for the parathyroid. 2.Bonomarlot® is the peptide for the bone marrow.��&HUOXWHQ��LV�WKH�SHSWLGH�IRU�WKH�FHQWUDO�QHUYRXV�V\VWHP��EUDLQ��4.Chelohart® is the peptide for the heart.5.Chitomur® is the peptide for the bladder.6.Endoluten® is the peptide for the pineal.7.Glandokort® is the peptide for the adrenal glands.8.Gotratix® is the peptide for the muscles.9.Libidon® is the peptide for the prostate gland.10.Pielotax® is the peptide for the kidneys.11.Sigumir® is the peptide for the cartilage.12.Stamakort® is the peptide for the stomach.��6XSUHIRUW��LV�WKH�SHSWLGH�IRU�WKH�SDQFUHDV�14.Svetinorm® is the peptide for the liver.15.Taxorest® is the peptide for the lungs.16.Testoluten® is the peptide for the testes.17.Thyreogen® is the peptide for the thyroid.18.Ventfort® is the peptide for the blood vessels.19.Visoluten® is the peptide for the eye retina.20.Vladonix® is the peptide for the thymus.21.Zhenoluten® is the peptide for the ovaries.

UPDATE: The recommended course is to start at 2 capsules D�GD\�IRU��GD\V��WRWDO��FDSVXOHV��$IWHUZDUG�WKH�FRXUVH�FDQ�be repeated at 2 capsules a day for 10-days (total 20 capsules) each quarter. Thus, after the initial intensive course all that is required are 4 boxes a year.

Peptide Bioregulators


improves the blood supply around the hair root, helping it to be stronger and healthier.

Just apply a small amount of MinSaw daily to the scalp and see the results for yourself in a few weeks time. Use it in combination with the Scalproller to improve uptake into the scalp.

Progesterone levels decline in women with age; in some cases progesterone levels are undetectable!

Sermorelin is a breakthrough development LQ�WKH�¿HOG�RI�JURZWK�KRUPRQH��*+��replacement. Sermorelin is the bioidentical molecule used by the pituitary gland to stimulate the production and release of GH into the bloodstream. Sermorelin is not GH; GH is a complicated molecule consisting of 191 amino acids. Sermorelin is a chain of 29 amino acids. Importantly LW�LV�WKH�¿UVW��DPLQR�DFLGV�RI�*+��WKH�SDUW�UHVSRQVLEOH�IRU�activation. This is what makes sermorelin stand head and shoulders over all previous agonists of GH. Sermorelin is *+�VLWH�VSHFL¿F�DQG�WKHUHIRUH�YHU\�HIIHFWLYH��:KDW�LV�PRUH��sermorelin has a negative feedback loop (unlike GH itself), so the issues of overdosing and safety associated with injections RI�*+�DUH�PLQLPL]HG��FRPSOHWHO\�DYRLGHG��6HUPRUHOLQ�LV�VWDEOH�DW�URRP�WHPSHUDWXUH�DQG�HI¿FDFLRXV�ZKHQ�XVHG�VXEOLQJXDOO\��These are additional factors that favor sermorelin as the next generation of GH activators. We are excited to introduce this sublingual liquid version of sermorelin which has been created

Sermorelin (Serm-Pro™)

Retin-A contains retinolic acid, a pure form of vitamin A that enhances blood supply to the skin’s surface and transforms the thicker, tougher skin into more youthful looking, elastic and fresher skin. Retin-A is the cream of choice for cosmetic surgeons to speed up the wound healing of cosmetic surgery and scarring etc.

UPDATE: We now also supply the new Retin-A® micro-gel which is designed to sit on the skin surface and release slowly.

Retin-A® (Retirides®)

3LUDFHWDP�ZDV�WKH�YHU\�¿UVW�QRRWURSLF��(commonly called smart drugs) to be developed. Despite being one of the very ¿UVW�SURGXFWV�WKDW�,$6�RIIHUHG�ZKHQ�ZH�went online in 1991, it remains one of our best selling products today! Why? Because LW�LV�D�YHU\�EHQH¿FLDO�PHPRU\�DJHQW�that has a great safety record, with very few side effects. Plus, it is cost effective. Piracetam has been shown to be safer than salt. This may be because it has a very small impact upon brain chemical levels and helps to improve electrical communication across the brain’s corpus callosum.

In medical terms piracetam is used to improve short term memory and to treat a wide variety of senile dementias as well as autism and Down’s syndrome and can also assist with travel and altitude sickness. Note: IAS offers the original UCB brand called Nootropil which is available in tablet and liquid form. 7KH�OLTXLG�IRUP�ZDV�VSHFL¿FDOO\�GHVLJQHG�IRU�FKLOGUHQ��LW�LV�sweetened with saccharin), but its advantages include being able to titrate low doses (if required) and also aid any person ZKR�KDV�GLI¿FXOW\�VZDOORZLQJ�WDEOHWV�

NEW: A great value generic piracetam is now available under the name of Pira-Pro™.

Piracetam (Nootropil®; also see Anacervix®)

The corpus callosum is the bundle of nerves that separates the two hemispheres of the brain.

Progesterone Progesterone is often the ‘missing’ hormone in the treatment of female menopause. What we mean by this is that whilst estrogen treatments, (see Esnatri™ for details) are often considered as a primary replacement hormone for women, progesterone is often forgotten about.The best known action of progesterone is its ability to help build bone mass. Progesterone levels fall rapidly in menopause and contribute to osteoporosis. Progesterone is strongly advocated to be taken in combination with any estrogen replacement program.

UPDATE: Our progesterone strength is Pharma grade. At 5% it is twice the dose that is found in US health food stores.

PQQ is the most newly discovered vitamin. In more than 200 studies it has been shown to improve overall energy levels, cognitive function and memory, reduce mitochondrial degradation and increase skin elasticity. Furthermore, it acts as a neuro and cardio protectant and helps to enhance nerve growth.

Releasing-Pro is a unique nasal spray that is designed to carry GHRP-6 into the bloodstream. GHRP-6 is an analogue of Ghrelin that has been shown to have VLJQL¿FDQW�HQKDQFHPHQW�HIIHFWV�RQ�,*)��OHYHOV�

PQQ (pyroloquinoline quinone)

Releasing-Pro®

We recommend one of Dr. Hertoghe’s hormone handbooks for further information about progesterone.


TA65®

A decline in the secretion of hormones from the thyroid gland (hypothyroidism) can result in poor concentration, confusion, memory problems, cold hands and feet, weight gain, menstrual problems, sleep disorders, dry skin, thinning hair and low energy levels. An underactive thyroid is also a major cause of a common painful musculoskeletal FRQGLWLRQ�NQRZQ�DV�¿EURP\DOJLD��$JLQJ�RIWHQ�OHDGV�WR�hypothyroidism. One of the most famous thyroid experts, Dr. Broda Barnes, stated that as many as 40% of the adult population could be hypothyroid. Thyroid supplements come in two forms; natural supplements and synthetic supplements. It is almost always better to use a whole-natural thyroid extract because the synthetic versions usually only comprise one of WKH�WK\URLG�KRUPRQHV��VXFK�DV��7��RU�7��ZKHUHDV��ZKROH�natural thyroids cover a fuller spectrum of thyroid hormones �LQFOXGLQJ�7��7��7��DQG�7��For further details about thyroid we recommended one of Dr. Hertoghe’s hormone handbooks.

Thyroid (Armour®; Synthroid®)

TRH is a hypothalamic hormone (technically a tri-peptide) whose real XVHV�DQG�EHQH¿WV�DUH�MXVW�FRPLQJ�WR�WKH�fore, primarily after research conducted by Dr. Walter Pierpaoli, the physician and scientist who H[SRVHG�WKH�EHQH¿WV�RI�PHODWRQLQ�WR�WKH�ZRUOG��'U��3LHUSDROL¶V�research suggests that TRH is a ‘master’ hormone responsible not just for helping to adjust thyroid hormones (its principle recognised role), but in helping to recorrect many imbalances throughout the body. For example in his animal experiments TRH supplements have encouraged old animals to:

• Re-establish spermogenesis, (reversing the age-related dysfunction of their testes).

• &RUUHFW�NLGQH\�G\VIXQFWLRQ��D�VLJQL¿FDQW�¿QGLQJ�IRU�UHQDO�issues).

• &RUUHFW�SDQFUHDWLF�G\VIXQFWLRQ��D�VLJQL¿FDQW�¿QGLQJ�IRU�diabetic issues).

• ,PSURYHV�PDQ\�OLSLG�SUR¿OHV�DQG�DLGV�ZHLJKW�ORVV�ZKHQ�used over a few months.

,$6�LV�GHOLJKWHG�WR�EH�WKH�¿UVW�RUJDQLVDWLRQ�LQ�WKH�ZRUOG�WR�RIIHU�a sublingual TRH tablet.

TRH (Abaris™)

7$��FRQWDLQV�D�KLJKO\�SXUL¿HG�VSHFLDOL]HG�extract of the Chinese herb astragalus. What makes this supplement totally unique is that LW�LV�WKH�¿UVW�QDWXUDO�VXEVWDQFH�WKDW�KDV�EHHQ�proven to act as a telomerase activator and to extend telomeres in humans (in-vivo). Telomeres are the strands on the ends of chromosomes that shorten each time the FHOO�GLYLGHV��7KLV�LV�D�VLJQL¿FDQW�SDUW�RI�WKH�destructive process of aging. Animals with longer telomeres enjoy a more productive and healthier older age and appear to live longer. TA65 production is carefully controlled by TA Sciences, who purchased the technology from the Geron Corporation. Whilst other substances have claimed to delay the shortening of telomeres, only TA65 has been clinically proven (and published) to actually lengthen short telomeres in humans. If you want the cutting-edge of antiaging supplementation and the best possible chances for longer telomeres, then TA65 is currently your best (and indeed only) clinically proven choice.

with the close cooperation of Dr. Richard Walker of SARA �6FLHQWL¿F�$SSOLHG�5HVHDUFK�LQWR�$JLQJ��D�ZRUOG�UHQRZQHG�antiaging expert.

UPDATE: Sermorelin is synergistic with GHRP2 or GHRP6.

Vasopressin is a porcine extracted source for this pituitary hormone which has a number of interesting roles.

Its approved medical use is to prevent frequent urination in conditions such as diabetes insipidus. For example, men with SURVWDWH�FRQGLWLRQV�FDQ�EHQH¿W�E\�OHVV�WULSV�in the night to urinate.

But vasopressin is also responsible for the laying down of memories in the hippocampus and it has been used to treat amnesia. In particular, it is cited by many for memory imprinting, this is the learning of new material before it is experienced. Therefore taking 1 or 2 sprays into each nostril 15-minutes before an exam, meeting or lecture etc., can induce a better detailed recall of events later.

=HR*ROG�(QKDQFHG�LV�WKH�ODWHVW�]HROLWH�IRUPXOD�from world chelation and detox expert, Dr. Garry Gordon. In this new ‘enhanced’ formula Dr. *RUGRQ�KDV�LQFOXGHG�WKH�KLJKHVW�JUDGH�RI�]HROLWH�for detox purposes along with the methylation agents and now added hydrogen for enhancement of energy.

Vasopressin

ZeoGold Enhanced®


Product A-Z listingHere is an alphabetical listing of IAS stocked products. See our cross-reference list of disorders that relate to these individual products. Much more information is available from our website including full ingredient/ excipient listings, doses and side effects etc. If you need any further information or can’t find what you require, please don’t hesitate to contact us. The inside back cover has all our details.

Testimonials “IAS has shown great vision and leadership, as an organisation focused mainly on the provision of contemporary medical interventions against aging, and in also supporting the SENS Foundation’s efforts to hasten the development of much more powerful future interventions.”

Dr. Aubrey De Grey

³,$6�LV�DQ�RXWVWDQGLQJ�UHVRXUFH�IRU�WKH�¿QHVW��most up-to-date news and information on healthy aging. They also offer products of WKH�KLJKHVW�LQWHJULW\�DQG�HI¿FDF\��,Q�IDFW��IAS is the world’s greatest source (often the only source) for the most cutting edge and advanced nutrients to ensure optimum health span and maximum life span.”

Nicholas Perricone, M.D.

“IAS has a history of making throughout WKH�ZRUOG�FUXFLDO��EXW�GLI¿FXOWO\�DFFHVVLEOH�medications available to patients. IAS is one of the pioneering societies in antiaging medicine that has helped this new medical specialty move forward.”

Thierry Hertoghe, M.D.

“I am a 77 year old Physician who has practiced medicine for nearly half a century. My antiaging research has permitted me to overcome serious health problems. Everyone FDQ�GR�WKLV��EXW�LW�UHTXLUHV�VSHFLDOL]HG�knowledge and the highest quality products. IAS is a vital link in my antiaging program because they continually provide both accurate information AND the high quality products we all require, if we are to achieve our maximum intended useful lifespan.”

Garry Gordon, MD, DO, MD (H)

“Every adult has the right to take care of his or her own personal health as he or she chooses. In the 20th and 21st centuries, this universal human right has been nearly obliterated by an ocean of nanny-state regulation and deliberate suppression of information by bureaucracies, with hidden and not-so-hidden agendas. International Antiaging Systems is a beacon of useful health care information and a literal island of freedom of health care product choice in our otherwise un-free health care world.”

Jonathan Wright, M.D.

See all professional and public testimonials at: ZZZ�DQWLDJLQJ�V\VWHPV�FRP�FRQWHQW��WHVWLPRQLDOV

Note: For use strictly by IAS private club members - IAS terms and conditions apply. All information is educational and does not replace the advice of your physician. Prescriptions are necessary where required by law; other restrictions may apply in some countries.


The following index underneath certain products means that known restrictions apply. For example:

Not shipped to UK Not shipped to EU Not shipped to JapanNot shipped to Australia (or New Zealand) Not shipped to Canada

Acetyl-L-Carnitine (see ATP-Boost™)

Adenosine Triphosphate (see ATP)

Agomelatine (see Valdoxan)

ATP-Boost™ (see ATP), Azilect® (see rasagiline)

Alfalfa (see Dr Gordon’s Organic Greens®), Allicin (see garlic), Alpha lipoic acid (see lipoic acid)

Adra-Pro™ 40x 300mg capsules retail $60 IAS price $49.99 - Item Code: 775

Adrafinil

Arginine (see Beyond GHS®; Nitric-Pro™), Argireline (see Crème-Pro™ Smoother), Arterial wave velocity (see Bio-Clip & Bio-Cuff)

Ascorbyl palmitate (see Crème-Pro™ Protector, Crème-Pro™ Smoother), Astaxanthin (see Crème-Pro™ Protector), Astragalus extract (see TA65®)

1st Line™ (OSCN, thiocyanate)1 complete kit retail $90 IAS price $79.99 - Item Code: 675

AniracetamAni-Pro™ 20x 750mg capsules retail $35 IAS price $29.99 - Item Code: 777

ACF228™ ACF228™ 45 capsules retail $60 IAS price $49.99- Item Code: 621

NEW: ACF228™ Breathe-Easy 1 inhaler retail $150 IAS price $139.99 - Item Code: 810

5HTP (5-hydroxy-tryptophan)5HTP-Pro™ 60x 50mg capsules retail $20 IAS price $17.49 - Item Code: 327

Acarbose Glucobay® 30x 100mg tablets retail $30 IAS price $27.49 - Item Code: 373

Aldosterone NEW: AldoSpray 10mg/5ml Ear Spray retail $160 IAS price $149.99 - Item Code: 982

Aminohydroxybutyric acid (see GABOB), Amino-phylline (see Crème-Pro™ Cellulite), Aminosyn (see Hair-Pro™), Amphoteric surfactants (see Nanogen® shampoo, Nanogen® conditioner)

Anacervix®Anacervix® 30x 420mg capsules retail $29 IAS price $24.99 - Item Code: 163

Andro-Pro™Andro-Pro™ 60 capsules retail $55 IAS price $49.99 - Item Code: 758

Anastrozole (Arimidex®)Anastrozole 28x 1mg tablets retail $149 IAS price $139.99 - Item Code: 849Anastro-Pro™ 28x 100mcg capsules retail $39.99 IAS price $32.49 - Item Code: 779

Aminoguanidine (pimagedine) Amino-Pro 90 x 75mg tablets retail $29 IAS price $24.99 - Item Code: 977

ATP (Adenosine Triphosphate)ATP-Boost™ 60x 20mg capsules retail $35IAS price $29.99 - Item Code: 821

Barley grass (see Dr Gordon’s Organic Greens®), BCI (see Beyond Chelation Improved®)


B12 (vitamin B12)Beyond B12® 40x 2mg sublingual tablets retail $30 IAS price $29.99 - Item Code: 477NEW: Cromatonbic® 8x1mg i.m.ampoules retail price $20 IAS price $17.49 - Item Code: 951

Beetroot (see Neo40®)

Beyond Clean® v2 (Calcium EDTA & Zeolite)

Benzoic acid (see Gerovital®), Beta alistine (see L-carnosine), Beta glucan (see Beyond Chelation Im-proved®, Nanogen® serum), Betaine (see TMG), Beta sitosterol (see Beyond Chelation Improved®), Beyond Any Multiple® (see Beyond Chelation Improved®)

bFGF (see Hair-Pro™), BHT (butylhydroxytoluene, see ACF228™)

Bioflavonoids (see Wobenzym®), Biological age measurement (see Bio-CLIP™, PulmoLife®), Bioperine (see Bio-En’R-Gy®), Biotin (see Beyond B12®; Beyond Chelation Improved®, HRT Plus®; BCI; Nitric-Pro™), Blood oxygenation measurement (see Bio-CLIP™), Blood pressure measurement (see Bio-CUFF™), Blueberry extracts (see Andro-Pro™)

Beyond Chelation Improved® (BCI)Beyond Chelation Improved® 30 sachets retail $80 IAS price $79.99 - Item Code: 351

NEW: Beyond Clean® v2 32 oz. bath salts retail $70 IAS price $69.99 - Item Code: 881

Beyond Fiber®Beyond Fiber® 504 grams powder retail $50 IAS price $49.99 - Item Code: 436

Bio-CUFF™ Bio-CUFF® one complete kit retail $150 IAS price $149.99 - Item Code: 715

Bio-En’R-Gy C® Bio En’R-Gy C® 200 grams powder retail $60 IAS price $59.99 - Item Code: 591

Bio-CLIP™ complete kit retail $1300 IAS price $1299.99 - Item Code: 653

BenfotiamineMilgamma Mono® 30x 50mg tablets retail $25 IAS price $22.49 - Item Code: 273

Bone-Pro2™ NEW: Bone-Pro2™ 60 capsules retail $39 IAS price $32.99 - Item Code: 870

Boluoke® (Lumbrokinase)NEW: Boluoke® 60 capsules retail price $108 IAS price $94.99 - Item Code: 839

BEC5 Curaderm®BEC5 Curaderm® 20ml tube cream retail $140 IAS price $129.99 - Item Code: 403

B-Cure® laser 1 Unit B-Cure® laser 1 Unit retail $795 IAS price $749.99 - Item Code: 850

Borate (see Andro-Pro™, Can-C™), Boron (see An-dro-Pro™, Beyond Chelation Improved®, BCI)

Bromelain (see Digestif®, Wobenzym®), Buxamin (see GABOB)

BromocriptineParlodel® 30x 2.5mg tablets retail $29 IAS price $24.99 - Item Code: 58

Caffeine (see Crème-Pro™ Cellulite), Calcium (see Bone-Pro™, Beyond Chelation Improved®, Nitric-Pro™)

Can-C™ eye-drops Can-C™ 2x 5ml vials retail $45 IAS price $39.99- Item Code: 456

Cabergoline (Dostinex®)Dostinex® 8x 0.5mg tablets retail $80 IAS price $74.99 - Item Code: 612


Note: Also called Beating Cellular Impurities by Dr Garry Gordon

Citrus bioflavonoids (see Beyond Chelation Improved®), Cocos nucifera oil (see Nanogen® conditioner)

CoQ10SRTM (Coenzyme Q10, ubiquinol, biquinone)NEW: CoQ10SRTM 30 x 100mg slow release capsules retail $30 IAS price $25.99 - Item Code: 824

Copper (see Beyond Chelation Improved®), Cortisol (cortisone, see Fludrocortisone, hydrocortisone), Cran-berry extracts (see Andro-Pro™)

Coenzyme Q10 (see CoQ10)

Cerebrolysin® Cerebrolysin® 5x 5ml i.m. ampoules retail $95 IAS price $84.99 - Item Code: 595

Cialis® (tadalafil) Cialis® 4x 20mg tablets retail $85 IAS price $79.99 - Item Code: 296

Ciproxin® (ciprofloxacin) Ciproxin® 14x 500mg tablets retail $35 IAS price $32.49 - Item Code: 948

Centrophenoxine (meclofenoxane)Centro-Pro™ 60x 250mg capsules retail $34.00 IAS price $29.99 - Item Code: 243

Carboxymethylcellulose (see Can-C™) , Car-bidopa (see Sinemet®), Carnosine (L-carnosine, see ACF228™, Can-C™, Can-C Plus™, L-carnosine), Catalase (see ACF228™)

Chlorella (see Dr Gordon’s Organic Greens®), Choline (see Beyond Chelation Improved®, centrophenoxine, krill), Chromium (see Beyond Chelation Improved®), Chromium polynicotinate (see ACF228™)

Can-C™ PlusCan-C Plus™ 90 tablets retail $40 IAS price $34.99 - Item Code: 629

Crème-Pro™ Cellulite Crème-Pro™ Cellulite 30ml pump cream retail $34 IAS price $24.99 - Item Code: 828

Colchicine (Colcrys®)NEW: Colchicine 40x 1mg tablets retail $19 IAS price $17.49 - Item Code: 835

Crème-Pro™ Moisturizer Crème-Pro™ Moisturizer 30ml pump cream retail $44 IAS price $39.99 - Item Code: 829

Crème-Pro™ Protector Crème-Pro™ Protector 30ml pump cream retail $59 IAS price $49.99 - Item Code: 830

Crème-Pro™ Smoother Crème-Pro™ Smoother 30ml pump cream retail $69 IAS price $59.99 - Item Code: 831

Cresote bush (see ACF228®, Digestif®)

Cycloastragenol (see TA65®), Cyclodextrin (see Co-Q10SR™), Cyprenil® (see deprenyl)

D3 (vitamin D)D3-5000™ 100x 5000 IU capsules retail $20 IAS price $14.99 - Item Code: 843

NEW: D3-Pro2™ 12x 50,000 IU capsules retail $30 IAS price $24.99 - Item Code: 842

CurcuminSR™ (turmeric extract) NEW: CurcuminSR™ (slow release) 30x 125mg capsules retail $25 IAS price $21.49 - Item Code: 841


Cobalt chlorideCobalt 100x 200mcg tablets retail $55 IAS price $49.99 - Item Code: 646

Dercos® (aminexil)Dercos® 200ml bottle shampoo retail $25 IAS price $22.49 - Item Code: 17

DIM-Pro2™NEW: DIM-Pro2 ™ 100 capsules retail $50 IAS price $44.99 - Item Code: 844

D-pantethine (see Can-C Plus™), D-panthenol (see Nanogen® conditioner)

DHA (docosahexaenoic acid, see krill), Diapid® (see vasopressin)

DMAE (dimethylaminoethanol, see centrophenoxine, Crème-Pro™ Smoother), DMSA (dimercaptosuccinic acid, see ACF228™), DMSO (Dimethyl sulfoxide, see laetrile), Docosahexaenoic acid (see DHA), Dostinex® (see cabergoline)

Ebixa (see Memantine) EDTA (ethylene diamine tetraacetic acid, see Beyond Chelation Improved®, Beyond Clean®, Beyond Fiber®), Eldepryl® (see depre-nyl), EPA (eicosapentaenoic acid, see krill), Ergoloid mesylate (see hydergine, nicergoline)

Di-IndolylMethane (DIM, see ACF228™, DIM-Pro™), DIM (see ACF228™, DIM-Pro™), Dimethicone (see Nanogen®)

DoxycyclineDoxycycline 8x 100mg capsules retail $29 IAS price $24.99 - Item Code: 164

DutasterideAvodart® 30x 0.5mg tablets retail $89 IAS price $79.99 - Item Code: 276

Dr. Gordon’s Organic GreensOrganic best of greens® 10 oz. bottle powder retail $35 IAS price $34.99 - Item Code: 688

Digestif™ Digestif® 60 capsules retail $19 IAS price $14.99 - Item Code: 626

Desmopressin (also see vasopressin)Minurin® 2.5ml nasal spray retail $39 IAS price $34.99 - Item Code: 229

Esnatri™ cream (bio-identical triple estrogen cream)Esnatri™ 50ml 100mg cream retail $55 IAS price $49.99 - Item Code: 25

Deprenyl (selegiline) Dep-Pro™ 20ml/ 300mg liquid (HCL) bottle retail $90 IAS price $84.99 - Item Code: 746 Jumex® 50x 5mg tablets retail $65 IAS price $54.99 - Item Code: 35

Essential Daily Defence® (see Beyond Chelation Improved®), Estradiol (see Esnatri™), Estriol (see Esnatri™), Estrone (see Esnatri™)

Fluconazole (Diflucan)Loitin® 7x 50mg capsules retail $39 IAS price $34.99 - Item Code: 307

Finesteride (also see Hair-Pro™)Finesteride generic 28x 5mg tablets retail $40 IAS price $37.49 - Item Code: 749

Proscar® 15x 5mg tablets retail $45 IAS price $39.99 - Item Code: 67

Florinef® (see Fludrocortisone)

Folic acid (folate, see ACF228™, Beyond Chelation Improved®, Beyond B12®; Dim-Pro2™, HRT Plus®, Lithi-um-Pro™, Nitric-Pro™), Forced Expiry Volume- Lungs (see PulmoLife®)


FludrocortisoneFludro-Pro™ 100x 20mcg tablets retail $24 IAS price $19.99 - Item Code: 759

Gamalate®Gamalate B6® 60x 250mg tablets retail $24 IAS price $19.99 - Item Code: 27

Galantamine (Reminyl®)Galantamine Pro 30x 8mg tablets retail $79 IAS price $69.99 - Item Code: 825

GabapentinNEW: Neurontin® 100x 300mg capsules retail $49 IAS price $44.99 - Item Code: 875

GABOB (also see Gamalate®)Gamibetal® 20x 500mg tablets retail $39 IAS price $34.99 - Item Code: 402

Gerovital-H3® Gerovital-H3® 5x 5ml ampoules retail $59 IAS price $49.99 - Item Code: 258

Gerovital-H3® 25x 100mg tablets retail $35 IAS price $29.99 - Item Code: 29

GH3-Pro™ 60x 100mg tablets retail $19 IAS price $14.99 - Item Code: 360

Fructoborate (see Andro-Pro™), GABA (gamma-ami-nohydroxybutyric acid, see Gamalate B6®, picamilone)

GH (growth hormone, see HGH)

Garlic (see see Beyond Chelation Improved®), Genotropin® (see HGH)

GHRP6 (see Releasing-Pro™), Ginkgo biloba (see Beyond Chelation Improved®), Glucophage (see metformin)

Glutathione (also see ACF228™ Breathe Easy)Advanced Cellular Glutathione® 2 oz. spray retail $45 IAS price $44.99 - Item Code: 832

Glycerine (glycerin, see Can-C™), Glycosides (see BEC5 Curaderm®), Grape seed extracts (see Beyond Chelation Improved®, Resveratrol-Pro™), Green tea extracts (see Resveratrol-Pro™), Growth hormone (see HGH)

GHRP2NEW: GHRP2-Pro™ 120ml 120mg liquid bottle retail $175 IAS price $159.99 - Item Code: 872

Hawthorne Berry (crataegus, see Beyond Chelation Improved®, Neo40®), Heart rate measurement (see Bio-CLIP™, Bio-CUFF™), HGH (human growth hormone, somatropin, see IGF-1, Sermorelin, Beyond GHS®, GA-BOB, GHRP2, GHRP6), Humatrope® (see HGH)

Hyaluronic acid (see Hyaluronan, Crème-Pro™ Protector, Hair-Pro™, Novisyn®)

Hydrogen (see Zeogold Enhanced®)

HRT Plus®(pueraria mirifica)HRT Plus® 60 tablets retail $50 IAS price $49.99 - Item Code: 496

Hydergine (ergoloid mesylate)Hydergin-Pro 30x 4.5mg capsules retail $49 IAS price $39.99 - Item Code: 952

HydrocortisoneHydrocort Pro 100x 5mg capsules retail $35 IAS price $29.99 - Item Code: 760

Hair-Pro™NEW: Hair-Pro™ 2 oz. spray bottle retail $180 IAS price $169.99 - Item Code: 765


IGF-1 (insulin like growth factor, see Hair-Pro™ also see Releasing-Pro™), Indol-3-Carbinol (I3C, see DIM)

Idebenone (also see Crème-Pro™ Protector)NEW: Ideb-Pro™ 60x 30mg tablets retail $29 IAS price $24.99 - Item Code: 492

Inosine (see Beyond GHS®), Inositol (see Beyond Chelation Improved®), Iodide (see ACF228™), Iodine (see ACF228™, Beyond Chelation Improved®), Isoflavo-noids (see HRT Plus®), Ixel® (see milnacipran), Jerusa-lem artichoke (see Beyond Fiber®), Joint-Pro™ (see Hyaluronan), Jumex® (see deprenyl), Ketoconazole (see Nizoral®)

L-citrulline (see Neo40®), L-cysteine (see Nanogen® conditioner), L-dopa (see Sinemet®), Lecithin (see Crème-Pro™ Cellulite), Levodopa (see Sinemet™), L-histidine (see Can-C Plus™), Lemon grass (see Dr Gordon’s Organic Greens®), Licorice (see Beyond GHS®, Digestif®), Lipoic acid (alpha version see Beyond Chelation Improved®; R-version see ATP-Boost™)

KrillKrill 60x 500mg gel capsules retail $45 IAS price $39.99 - Item Code: 584

L-carnosine (also see ACF228™; Can-C™; Can-C Plus™)Carnosine 60x 250mg capsules retail $25 IAS price $22.49 - Item Code: 784

Injection packsIntramuscular kit 30x pack retail $30 IAS price $27.49 - Item Code: 439

Subcutaneous kit 30x pack retail $30 IAS price $27.49 - Item Code: 438

Laetrile (amygdalin; VitaB17®)Vita-B17 cream 50ml 1% retail $99 IAS price $89.99 - Item Code: 763

L-arginine (see arginine), Lasers (see B-Cure®, Vie-Light®)

L-methione (see ACF228™; Can-C Plus™), L-proline (see Nitric-Pro™), Lucidril® (see centrophenoxine), Lumbrokinase (see Boluoke®), Lupine extract (see Nanogen® serum)

Lysine (see Nitric-Pro™)

Magnesium (see Andro-Pro™, Beyond Chelation Improved®, Bone-Pro2™, Digestif®, Gamalate B6®, Nitric-Pro™), Malic acid (see Beyond Chelation Im-proved®), Manganese (see Beyond Chelation Im-proved®), Mastic (see Digestif®), Meclofenoxane (see centrophenoxine)

L-tryptophanL-Tryp-Pro™ 50x 500mg capsules retail $20 IAS price $17.49 - Item Code: 666

Maca (lepidium meyenii walp)Longevity Maca 175 grams powder retail $40 IAS price $37.49 - Item Code: 851

Melatonin (Melatonin Zn Se®) MZS™ 60x 3mg tablets retail $30 IAS price $19.99 - Item Code: 701

Melanocyte stimulating hormone (see MSH)

Memantine (Namenda®; Ebixa®)Memantine-Pro™ 42x 10mg capsules retail $105 IAS price $89.99 - Item Code: 826

Lithium (orotate)NEW: Lith-Pro™ 100x5mg capsules retail $30 IAS price $24.99 - Item Code: 906

Metformin (Glucophage®)Metforal® 50x 500mg tablets retail $25 IAS price $22.99 - Item Code: 42

NEW: Metformin SR® 56x 500mg tablets retail $30 IAS price $27.99 - Item Code: 874

Methione (see Beyond Chelation Improved®), Milk Protein (see Bone-Pro2™)

Note: The UK can order in Pounds Sterling at: www.melatoninznse.com


Moclobemide (Manerix®)Moclamine® 30x 150mg tablets retail $29 IAS price $24.99 - Item Code: 39

MinSaw™ MinSaw™ 30ml bottle topical liquid retail $45 IAS price $39.99 - Item Code: 728

Milnacipran (Savella®)Ixel® 56x 50mg tablets retail $65 IAS price $59.99 - Item Code: 400

Minoxidil (see MinSaw™)

Miroestrol (see HRT Plus®), Mito-Pro™ (see ATP-Boost™)

Molybdenum (see Beyond Chelation Improved®), MSM (methylsulfonomethane, see Beyond Chelation Improved®, Bio-En’R-Gy®, Nitric-Pro™)

N-acetylcysteine (see ACF228™, Can-C™ Plus), NADH (Nicotinamide adenine dinucleotide, see Crème-Pro™ Moisturizer, PQQ)

Nanogen® conditionerNanogen® 240ml tube conditioner MEN retail $20 IAS price $19.99 - Item Code: 886Nanogen® 240ml tube conditioner WOMEN retail $20 IAS price $19.99 - Item Code: 887

Nanogen® serumNanogen® 30ml serum dropper MEN retail $55 IAS price $54.99 - Item Code: 890Nanogen® 30ml serum dropper WOMEN retail $55 IAS price $54.99 - Item Code: 891

Namenda® (see Memantine)

Naltrexone (Navcol®) Naltrex-Pro™ 30x 4.5mg capsules retail $70 IAS price $59.99 - Item Code: 637

Nanogen® shampooNanogen® 240ml tube shampoo MEN retail $18 IAS price $17.99 - Item Code: 888Nanogen® 240ml tube shampoo WOMEN retail $18 IAS price $17.99 - Item Code: 889

Niacin (nicotinate, niacinamide, see vitamin B3)

Nettle root extract (see Prostate-Pro™)

Needles (see injection packs), Neurontin® (see Gabapentin)

Neo40®Neo40 Daily® 30x lozenges retail $60 IAS price $59.99 - Item Code: 790

Neydent toothpasteNeydent toothpaste 50ml tube retail $18 IAS price $15.99 - Item Code: 118

Nitric Oxide Saliva Test StripsNeo40® 10 saliva strips $25 IAS price $24.99 - Item Code: 866

Nitric-Pro™ Nitric-Pro™ 225 grams powder retail $45 IAS price $39.49 - Item Code: 792

Nizoral® shampoo (2% ketoconazole) Nizoral® 60ml bottle shampoo retail $19 IAS price $14.99 - Item Code: 437

NicergolineSermion® 50x 10mg tablets retail $50 IAS price $47.49 - Item Code: 489

MSH (melanocyte stimulating hormone) NEW: MSH2-Pro™ 5ml 500IU nasal spray retail $79 IAS price $69.99 - Item Code: 905


Novisyn® Hyaluronic AcidNovisyn® Hyaluronic Acid 30 x 5ml liquid sachets retail $30 IAS price $29.49 - Item Code: 900

Nordihydroguaiaretic acid (NDGA, see ACF228™, Digestif®), Norditropin® (see HGH), Oat grass (see Dr Gordon’s Organic Greens®), Omega 3 (see Beyond Chelation Improved®, krill), Omega 6 (linoleic acid, GLA, see Beyond Chelation Improved®, krill), Omega 9 (oleic acid, see Beyond Chelation Improved®, krill), Oxythiocynate (OCSN, thiocynates, see 1st Line™)

PABA (para-aminobenzoic acid, see Beyond Chela-tion Improved®, Gerovital®), Palmitate (see Beyond Chelation Improved®), Pancreatin (see Wobenzym®), Panthenol (pantothenic acid, see vitamin B5), Papain (see Beyond Chelation Improved®, Wobenzym®)

OxytocinOxy-Pro® 5ml 500 IU nasal spray retail $65 IAS price $59.99 - Item Code: 823

Oxy-Sub™ 24x 20 IU sublingual troches retail $85 IAS price $79.99 - Item Code: 660

Pentavita (see Nanogen®)

Please contact us for the range of professional equipment currently available. Further details are available at www.pemf-therapy.eu

PEMF (Pulsed electronic magnetic field)

Penicillin (Penilevel®)Penilevel® 20x 250mg sachets powder retail $34 IAS price $29.99 - Item Code: 952

Peptide Bioregulators (also see Youth Gems®)NEW: Adrenals (Glandokort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 853

NEW: Blood vessels (Ventfort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 868

NEW: Bone Marrow (Bonomarlot®) 20x 200mg capsules retail $90 IAS price $79.99

NEW: Brain (Cerluten®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 867

NEW: Cartilage (Sigumir®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 893

NEW: Eyesight (Visoluten®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 856

NEW: Kidneys (Pielotak®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 869

NEW: Liver (Svetinorm®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 894

NEW: Lungs (Taxorest®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 959

NEW: Muscle (Gotratix®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 978

NEW: Parathyroid (Bobothyrk®) 20x 200mg capsules retail $90 IAS price $79.99

NEW: Pancreas (Suprefort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 892

NEW: Pineal (Endoluten®) 20x 200mg capsules retail $115 IAS price $99.99 - Item Code: 884

NEW: Prostate (Libidon®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 854

NEW: Testes (Testoluten®) 20 x 200mg capsules retail $90 IAS price $79.99 - Item Code: 855

NEW: Thyroid (Thyreogen®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 883

NEW: Stomach (Stamacort®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 896

NEW: Heart (Cheloheart®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 898

NEW: Bladder (Chitomur®) 20 x 200mg capsules retail $90 IAS price $79.99 - Item Code: 897

NEW: Ovaries (Zhenoluten®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 899

NEW: Thymus (Vladonix®) 20x 200mg capsules retail $90 IAS price $79.99 - Item Code: 882


Phosphatidylcholine (see Beyond Chelation Im-proved®, Crème-Pro™ Cellulite), Phosphatidylserine (see Beyond Chelation Improved®), Phospholipids (see krill), Phosphorous (see Nitric-Pro™)

Picamilone Pic-Pro™ 60x 50mg tablets retail $24IAS price $19.99 - Item Code: 184

Phenytoin (Dilantin®, Epanutin®)Phen-Pro™ 28x 25mg capsules retail $25 IAS price $19.99 - Item Code: 786

Polyphenols (see grape seed extract), Pomegranate extracts (see Andro-Pro™), Potassium (see Beyond Chelation Improved®, Gerovital®), Potassium iodide (see ACF228™), Potassium iodine (see ACF228™)

PulmoLife® (FVC biological age)PulmoLife®1 Spirometer + 4 tubes retail $160 IAS price $139.99 - Item Code: 781

PulmoLife®25 additional tubes retail $25 IAS price $19.99 - Item Code: 782

PQQ (pyroloquinoline quinone)NEW: PQQ-Pro™ 30x 20mg capsules retail $40 IAS price $35.99 - Item Code: 837

Prostate-Pro2™NEW: Prostate-Pro2™ 60 capsules retail $35 IAS price $29.99 - Item Code: 871

Pyridoxamine Pyridox-Pro™ 60x 50mg tablets retail $39 IAS price $32.49 - Item Code: 449

PramiracetamPramPro™ 40x 300mg tablets retail $60 IAS price $49.99 - Item Code: 451

PregnenolonePregPro™ 50x 100mg capsules retail $25 IAS price $21.49 - Item Code: 335

Propranolol (Inderal®)Inderal® 30x 40mg tablets retail $25 IAS price $19.99 - Item Code: 34

Procaine (Novocain®, see Gerovital®, Crème-Pro™ Moisturizer)

Pueraria mirifica (see HRT Plus®), Pulsed electronic magnetic field (see PEMF) Pulsed magnetic therapy (PMT, see PEMF), Pygeum africanum (see Nanogen®, Prostate-Pro2™)

PyritinolCerbon 6® 60x 100mg tablets retail $29 IAS price $24.99 - Item Code: 167

Pyroloquinoline quinone (see PQQ), Quercetin (see Digestif®, Resveratrol-Pro™)

RasagilineNEW: Rasagiline-Pro™ 30x 1mg capsules retail $95 IAS price $89.99 - Item Code: 827

Pimagidine (see aminoguanidine)


Piracetam (also see Anacervix®) Nootropil® 20 grams 100ml liquid retail $25 IAS price $21.49 - Item Code: 50Nootropil® 60x 800mg tablets retail $30 IAS price $27.99 - Item Code: 205Pira-Pro™ 100x 800mg tablets retail $24 IAS price $17.99 - Item Code: 873

Progesterone Progesterone 50ml 2.5 grams (5%) cream retail $35 IAS price $29.99 - Item Code: 789

Resveratrol (also see ACF228™, Beyond Chelation Improved®, Crème-Pro™ Protector, MinSaw™, Resveratrol-Pro™)NEW: Resveratrol-SR™ (slow release) 30x 150mg capsules retail $34 IAS price $29.99 - Item Code: 983

Red algae (carrageenan, see Beyond Chelation Improved®), Red clover herb extract (see Pros-tate-Pro2™), Red yeast (see Beyond Chelation Im-proved®)

Reminyl® (see Galantamine)

Reboxetine (Davedax®)Edronax® 60x 4mg tablets retail $70 IAS price $64.99 - Item Code: 22

Releasing-Pro™ (GHRP6)NEW: Releasing-Pro™ 5ml 500IU nasal spray retail $89 IAS price $79.99 - Item Code: 904

42

Retin-A®Retirides® 30ml 0.025% cream retail $39 IAS price $29.99 - Item Code: 254Retirides® 30ml 0.050% cream retail $49 IAS price $39.99 - Item Code: 764Retirides® 30ml 0.100% cream retail $59 IAS price $49.99 - Item Code: 74Retin-A® 20ml 0.100% micro-gel retail $80 IAS price $74.99 - Item Code: 744

Retinolic acid (tretinoin, see MinSaw™, Retin-A®), Ri-bonucleic acids (RNA, see Cerebrolysin®, NeyDent®), Ribose (see Bio-En’R-Gy®), Rice bran husks (see Beyond Fiber®), R-lipoic acid (see ATP-Boost™)

RoxithromycinRulid® 10x 150mg tablets retail $35 IAS price $29.99 - Item Code: 635

Rutin (see Wobenzym®), Saizen® (see HGH), Salicylic acid (see BEC5 Curaderm®, Nanogen® shampoo)

SAMe (S-Adenosyl-L-Methionine)SAMYR® 20x 400mg enteric-coated tablets retail $69 IAS price $64.99 - Item Code: 231

Saw palmetto (Serena repens, see MinSaw™; Nano-gen®, Prostate-Pro2™)

Scalproller®Scalproller® 0.3mm roller kit retail $75 IAS price $69.99 - Item Code: 762

Selepryl® (see deprenyl), Selegiline (see deprenyl), Selenium (see ACF228™, Beyond Chelation Im-proved®, Dim-Pro2™, MZS™, Prostate-Pro2™, thymus)

SermorelinSermo-Pro® 30ml/ 30mg liquid bottle retail $225 IAS price $199.99 - Item Code: 714

Shave grass (see Dr Gordon’s Organic Greens®), Sili-con/ Silica (see Beyond Chelation Improved®; Nano-gen™, Wobenzym®)

Solasodine glycosides (see BEC5 Curaderm®), Somatomedin C (see IGF-1), Somatropin (see HGH), Spirulina (see Dr Gordon’s Organic Greens®)

Silver protein (ACS®)Advanced Cellular Silver 200® 2 oz. spray retail $35 IAS price $34.99 - Item Code: 596

Stevia (see Dr Gordon’s Organic Greens®), Superox-ide dismutase (SOD, see Nanogen® serum), Syringes (see injection packs)

Stablon® (tianeptine)Stablon® 60x 12.5mg tablets retail $69 IAS price $62.49 - Item Code: 748

TA65®TA65® 30 capsules IAS price $218.99 - Item Code: 755

TA65® 90 capsules IAS price $599.99 - Item Code: 754

Tamanu Tamanu 50ml bottle oil retail $29 IAS price $24.99 - Item Code: 724


Telomeres/ telomerase (see TA65®), Temple viper venom (synthetic, see Crème-Pro™ Smoother)

Thymus (also see peptide bioregulator)Thym-Uvocal® 90x 200mg capsules retail $115 IAS price $99.99 - Item Code: 691

Tetracycline Ambramicina® 16x 250mg tablets retail $25 IAS price $22.49 - Item Code: 143

NEW: Nature® 1½ grain 100x 90mg tablets retail $75 IAS price $69.99 - Item Code: 901

Nature® 2 grain 100x 120mg tablets retail $85 IAS price $79.99 - Item Code: 460

Thyroid (also see peptide bioregulator)

Our natural thyroids include:

Armour® 100x 15mg tablets retail $75 IAS price $69.99 - Item Code: 411





ERFA 100x 30mg tablets retail $55 IAS price $49.99 - Item Code: 736



Nature® 100x 15mg tablets retail $45 IAS price $39.99 - Item Code: 613

Nature® 100x 30mg tablets retail $50IAS price $44.99 - Item Code: 324

Nature® 100x 60mg tablets retail $65 IAS price $59.99 - Item Code: 323

Thyrotropin releasing hormone (see TRH), TMG (trimethylglycine, betaine, see Beyond Chelation Improved®, Bio-En’R-Gy®), Tocotrienols (see Beyond Chelation Improved®), Tribulus terrestris (see An-dro-Pro™, Beyond GHS®)

TRH (thyrotropin releasing hormone) NEW: Abaris™ 20 x 5mg sublingual tablets retail $250 IAS price $199.99 - Item Code: 793

Trypsin (see Wobenzym®), TRX (see Hair-Pro™), Tur-meric (see curcumin), Ubiquinol (see CoQ10), Ubiqui-none (see CoQ10), Urea (see BEC5 Curaderm®), Urtica dioica (see Nanogen®)

Valdoxan® (agomelatine) Valdoxan® 28x 25mg tablets retail $69 IAS price $59.99 - Item Code: 690

Vasopressin (also see desmopressin)NEW: Vaso-Pro® 5 ml 500 IU nasal-spray retail $75 IAS price $69.99 - Item Code: 838


Our synthetic thyroids include:

NEW: Eutirox® (T4) 100x 100mcg tablets retail $34 IAS price $27.49 - Item Code: 662

NEW: T3Pro™ (T3) 50x 20mcg tablets retail $35 IAS price $29.99 - Item Code: 960

VEGF (see Hair-Pro™, Nanogen® conditioner, Nano-gen® serum, Nanogen® shampoo)

Venlafaxine (Efexor®)Venlafaxine 60x 37.5mg tablets retail $45 IAS price $39.99 - Item Code: 488

Vitamin A (beta carotene, palmitate, see Beyond Chelation Improved®), Vitamin B1 (thiamine, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B1 (see benfotiamine), Vitamin B2 (riboflavin, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B3 (niacin, niacinamide, see Beyond Chelation Improved®, Crème-Pro™ Cellulite, Nanogen® serum, Nitric-Pro™, picami-lone; Xan-Pro™), Vitamin B5 (panthenol, pantothenic acid, see Beyond Chelation Improved®, Nitric-Pro™), Vitamin B6 (pyridoxine, see ACF228™, Andro-Pro™, Beyond B12®, Beyond Chelation Improved®, DIM-Pro2™, Gamalate B6®; HRT Plus®, Nanogen®; Nitric-Pro™), Vitamin B6 (see pyridoxamine), Vitamin B12 (cobal-amin, see B12®, Beyond Chelation Improved®, Crème-Pro™ Moisturizer, Cromatonbic®, DIM-Pro2™), Lithium, Neo40®), Vitamin D3 (cholecalciferol, see D3, Beyond Chelation Improved®, Bone-Pro2™, Prostate-Pro2™), Vitamin C (ascorbic acid, see Beyond Chelation Im-proved®, Bio-En’R-Gy C®, Digestif®; MinSaw™, Neo40®, Nitric-Pro™)

VinpocetineIntelectol® 50x 5mg tablets retail $19 IAS price $16.99 - Item Code: 91

Vielight® laser NEW: Vielight® 633 inter-nasal laser retail $300 IAS price $299.99 - Item Code: 958

Viagra® (sildenafil) Viagra® 4x 100mg tablets retail $79 IAS price $69.99 - Item Code: 90

Vincamine (see Anacervix®)

Vitamin C test strips (Vitacheck-C®) NEW: Vitacheck-C® 50 strips retail $18 IAS price $15.99 - Item Code: 774

Vitamin E (tocopherols, see Beyond Chelation Im-proved®, Can-C Plus™, DIM-Pro2™, Nitric-Pro™, Pros-tate-Pro2™, Resveratrol-Pro™), Vitamin K2 (menatre-trenone, see Beyond Chelation Improved®, Bone-Pro2™), Wheat grass (see Dr Gordon’s Organic Greens®)

Wobenzym-N®Wobenzym® 200 tablets retail $75 IAS price $72.49 - Item Code: 381

Xan-Pro® (xanthinol nicotinate) Xan-Pro® 50x 150mg tablets retail $24 IAS price $17.49 - Item Code: 552

Youth Gems® (topical peptide bioregulators; each contains thymus, pineal, cartilage and blood vessel peptides plus ginseng)

NEW: Youth Gems® 200ml bottle body milk retail $49 IAS price $44.99 NEW: Youth Gems® 50ml pump day cream retail $69 IAS price $64.99NEW: Youth Gems® 30ml dropper serum retail $89 IAS price $79.99 NEW: Youth Gems® 200ml bottle tonic retail $44 IAS price $39.99

ZeoliteNEW: ZeoGold Enhanced® (zeolite and hydrogen) 50g powder retail $65 IAS price $64.99 - Item Code: 950

Advanced Cellular Zeolite®2 oz. spray retail $45 IAS price $44.99 - Item Code: 833

Zinc (see Andro-Pro™, Beyond Chelation Improved®, Can-C Plus™, MZS™, Nanogen® shampoo, Thym-Uvocal®)

Yohimbine (also see Crème-Pro™ Cellulite)Plain Prowess® 100x 5mg tablets retail $59 IAS price $49.99 - Item Code: 94

DIDN’T FIND WHAT YOU WERE LOOKING FOR? PLEASE CONTACT US WITH YOUR REQUIREMENTS.


AdaptogensHRT Plus®, maca, Quinton®

Addison’s disease Aldosterone, Peptide Bioregulator- Glandokort®

ADHD (ADD, attention deficit disorder, see mental stimulants)

Adrenal fatigueAldosterone, hydrocortisone, Peptide Bioregulator - Glandokort®

AGE (Advanced Glycated End Products, cross linking of proteins)

ACF228™, aminoguanidine, Can-C Plus™, L-carnosine, metformin, pyridoxamine

Age Related Macular Degeneration (see eyesight)

Age Related Mental Decline (see cognitive)

Aids (see HIV)

Alcoholism (also see compulsive disorders) 5HTP, L-tryptophan, memantine

Allergies%LR�(Q¶5�*\�&��SUHJQHQRORQH��7K\PXV��:REHQ]\P�

ALS (amyotrophic lateral sclerosis, see Lou Gehrig’s disease)

Alzheimer’s (see senile dementia)

Amino acids (including di-peptides)5HTP, ACF228™, ATP-Boost™, Beyond GHS®, L-carnosine, L-tryptophan, Nitric-Pro

Anabolic (see growth hormone & testosterone)

Anginas (see heart, arterial & blood)

Animal useCan-C™ eye-drops, deprenyl, L-tryptophan, peptide bioregulators

Antiaging (as impacting on a particular theory of aging)

Calorie Restriction: L-carnosine, metformin, resveratrol

Free radical: ACF228™Glycation: Aminoguanidine+D\ÀLFN��/�FDUQRVLQH��7$��Membrane: CentrophenoxineMitochondrial: Hydergine, PQQNeuroendocrine: Metformin, TRHRotational: MelatoninTelomeres: TA65®

Antibiotics (also see influenzas & infections)Ciproxin, doxycycline, penicillin, roxithromycin, tetracycline

Anti-depressants (also see depression & wellbeing)

Lithium-Pro™, milnacipran (Ixel®), moclobemide (Manerix®), reboxetine (Edronax®), Stablon®, Valdoxan®, venlafaxine (Efexor®)

Anti-glycation (see AGE)

Anti-inflammatory (see inflammation)

Anti-oxidants (free radical scavengers)ACF228™, Active H-minus®, ATP-Boost™, Bio-En’R-Gy®, glutathione, idebenone, melatonin, pyritinol

Anxiety (see stress)

ARMD (see eyesight)

Aromatase inhibitors$QDVWUR]ROH��$ULPLGH[��%H\RQG�+57��',0�3UR��progesterone

Arterial (See heart, arterial & blood)

Arthritis (rheumatoid & osteo)*HURYLWDO�+��NULOO��1RYLV\Q��SUHJQHQRORQH��S\ULWLQRO��6$0H��WK\PXV��:REHQ]\P�

Asthma (see Allergies)

At-home therapeutic kitsB-Cure® laser, Vielight® laser

Autism (also see chelation agents)Oxytocin, piracetam

Back Problems (see spine)

Bell’s palsyBeyond B12®

Beta blockersPropranolol

Biological age measurementBio-CLIP™, PulmoLife®

Blood disorders (see heart, arterial & blood)

Blood pressureNeo40®, Nitric-Pro™, oxytocin, propranolol, vinpocetine

Bone problems (also see joints & arthritis) Andro-Pro™, Bone-Pro2™, Esnatri™, Peptide Bioregulator - Bonomarlot®, progesterone, SAMe, thyroid

Breathing (see Lungs)

45

Condition cross reference listThis cross-reference list highlights individual products that have been used to treat & prevent various aging disorders. Note: It does not mean that all these products are synergistic together.



Cancer (also see anti-oxidants & radiation)�VW�/LQH��DQDVWUR]ROH��$ULPLGH[��%(&��&XUDGHUP��%LR�(Q¶5�*\�&��EURPRFULSWLQH��&XUFXPLQ65��'��DIM-Pro2™, HRT Plus®, laetrile, melatonin, metformin, naltrexone, progesterone, Resveratrol-Pro™, thymus, TRH, :REHQ]\P�

Cardiovascular (see heart & arterial disorders)

Cataplexy (sudden fatigue)$GUD¿QLO��SLFDPLORQH�

Cataract (also see eyesight)Can-C™, Can-C Plus™

Central Nervous System (CNS)Peptide Bioregulator - Cerluten®

Chelation agents (removing heavy metals, also see detox)

Beyond Chelation Improved®, Beyond Fiber®, Bio-En’R-Gy C®, centrophenoxine, Dr. Gordon’s organic greens®, /�FDUQRVLQH��]HROLWH

Cholesterol (see blood disorders)

Chronic fatigue syndrome (see mental stimulants & physical energy improvement)

Cognitive (also see memory & senile dementias)$OHUWQHVV��$GUD¿QLOCreativity: Aniracetam, piracetam, pramiracetam)RFXV��FRQFHQWUDWLRQ��'HSUHQ\O��GHVPRSUHVVLQ��phosphatidylserine, vasopressinEnergy: ATP-Boost™, centrophenoxine, picamilone*HQHUDO�VXSSRUW��*HURYLWDO�+��YLQSRFHWLQHIntelligence: HydergineWork load: Hydergine, thyroid

Compulsive disorder treatment (also see alcoholism)

5HTP, Gamalate®, L-tryptophan, picamilone

Cortisol alteration (also see stress)$OGRVWHURQH��ÀXGURFRUWLVRQH��*$%2%��*DPDODWH��hydrocortisone, Peptide Bioregulator - Glandokort®, *HURYLWDO�+��SKHQ\WRLQ

Crohn’s diseaseNaltrexone

Cross linking (see AGE)

Deep vein thrombosis (see frequent fliers)

Dental (see teeth & gums)

Depression (also see well-being & anti-depressants)5HTP, aniracetam, ATP-Boost™, CurcuminSR™, '��GHSUHQ\O��*HURYLWDO�+��/LWKLXP��/�WU\SWRSKDQ��milnacipran, picamilone, piracetam, pramiracetam, pregnenolone, SAMe, thymus, thyroid

Detox (also see chelation agents)Bio-En-R-Gy C®, Beyond Clean®, Beyond Fiber®, DIM-3UR��'U��*RUGRQ¶V�RUJDQLF�JUHHQV��]HROLWH

DHT alteration (dihydrotestosterone)'XWDVWHULGH��¿QDVWHULGH��+DLU�3UR��0LQ6DZ��Nanogen’s®, Peptide Bioregulator - Libidon®, progesterone

DiabetesAcarbose, aminoguanidine, ATP-Boost™, benfotiamine, krill, L-carnosine, metformin, Nitric-Pro™, Peptide Bioregulator- Suprefort®, pyridoxamine, TRH, thyroid

Diabetes insipidus (see urination)

Diagnostic products (see at-home diagnostics and at-home test kits)

Dieting (See weight loss)

Digestive issuesBeyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Peptide Bioregulator - Stamakort®

DNA support (also see telomeres)&R4��'��NULOO��/�FDUQRVLQH��3HSWLGH�%LRUHJXODWRUV��344��Resveratrol-Pro, TA65®

Down’s syndromeMelatonin, piracetam

Dr. Gordon’s recommended productsBeyond B12®, Beyond Chelation Improved®, Beyond Clean2®, Beyond Fiber®, Beyond GHS®, Bio En’R-Gy C®, Dr Gordon’s Organic Greens®, HRT Plus®, maca, VLOYHU�SURWHLQ��]HROLWH

Dr. Pierpaoli’s recommended productsMelatonin, TRH

Dr. Wright’s recommended productsEsnatri, cobalt chloride, progesterone

Energy improvement (see physical energy & mental stimulants)

Enzymes%ROXRNH��:REHQ]\P�

EpilepsyGABOB, Gamalate®, phenytoin

Erectile dysfunction (also see sex-libido & premature ejaculation)

Andro-Pro™, cabergoline, Cialis®, Neo40®, Nitric-Pro™, oxytocin, Viagra®, yohimbine

Estrogen alteration (both increases & decreases)$QDVWUR]ROH��$ULPLGH[��FREDOW�FKORULGH��',0�3UR��Esnatri™, HRT Plus®, progesterone

Excitotoxins (reduction)Deprenyl, idebenone, L-carnosine, Lithium, memantine

Eyesight (also see cataract, ARMD & glaucoma)ARMD: MZS™Cataracts: Can-C™, Can-C™ PlusContact lenses: Can-C™Dry eyes: Can-C™General support: Aminoguanidine, Peptide Bioregulator - Visoluten®, vinpocetineGlaucoma: Can-C™Retinal: MZS™, nicergoline, picamilone

FertilityMelatonin, metformin, Peptide Bioregulator - Zhenoluten®, TRH

Fibromyalgia (also see physical energy & mental

stimulants & pain relief)1st Line, milnacipran, naltrexone, oxytocin

First Aid cabinet1st Line™, silver protein

Free radical scavengers (see anti-oxidants)

Frequent fliers1st Line, GABOB, Gamalate®, L-tryptophan, melatonin, Neo40®, Nitric-Pro™, picamilone, piracetam, pregnenolone, Resveratrol-Pro™, silver protein

Gastrointestinal (see digestive)

Glaucoma (see eyesight)

Glucose control (see diabetes)

Glycation prevention (see AGE)

GoutColchicine

Growth hormone (improvement)Beyond GHS®, bromocriptine, deprenyl, GABOB, Gamalate®, GHRP2, GHRP6, hydergine, Neo40®, Nitric-Pro™, sermorelin, thymus, thyroid

Hair improvement'HUFRV��GXWDVWHULGH��¿QDVWHULGH��*HURYLWDO�+��+DLU�3UR��NULOO��0LQ6DZ��1DQRJHQ¶V��1LWULF�3UR��1L]RUDO�

Headaches (see migraines)Health diagnostics (see at home test kits)Hearing disorders

$OGRVWHURQH��$QDFHUYL[��ÀXGURFRUWLVRQH��QLFHUJROLQH��picamilone, vinpocetine

Heart, arterial & blood (includes blood markers)Arteries (hard): Aminoguanidine, Bio-CLIP™, Bio-CUFF™, L-carnosine, Resveratrol-Pro™Blood pressure (high): Neo40®, Nitric-Pro™, Propranolol, vinpocetineCalcium: Peptide Bioregulator - Bobothyrk®Cholesterol (high): Beyond B12®, Beyond Fiber™, CoQ10, *HURYLWDO�+��75+��;DQ�3UR�Dilation (nitric-oxide): Neo40®, Nitric-Pro™, Vielight®)LEULQRJHQ��&XUFXPLQ65��75+��:REHQ]\P�General support: CoQ10, krill, Peptide Bioregulators - &KHORKDUW��9HQWIRUW��344��YLQSRFHWLQH��:REHQ]\P�Glucose (high): Acarbose, metformin, TRHGlycated end-products: Aminoguanidine, metforminHeart pulse (irregular): ATP-Boost™, Bio En’R-Gy C®, thyroidHeavy metals (chelate): Beyond Chelation Improved®, Beyond Fiber®, Bio En’R-Gy C®Hemorrhoids: Nitric-Pro™Homocysteine: Beyond B12®, Beyond Chelation Improved®, Bio En’R-Gy C®, TRHLipofuscin: CentrophenoxinePlaques (clots): Boluoke®Triglycerides: Bio En’R-Gy C®, CurcuminSR™, krill, TRH

Hepatitis (see liver and infections)

Herpes (also see anti-biotics)�VW�/LQH��$&)��VLOYHU�SURWHLQ��:REHQ]\P�

HGH (see growth hormone)

HIV (also see immune system improvement)1st Line™, melatonin, naltrexone, Thymus

Homocysteine (see blood disorders)

Hormones (includes hormonal support supplements)Bio-identical: Aldosterone, Esnatri™, melatonin, MSH, oxytocin, pregnenolone, progesterone, TRHNatural (animal): Armour® thyroid, ERFA® thyroid, Nature® thyroid, thymus, vasopressinSynthetic: Desmopressin, Eutirox® thyroid, ÀXGURFRUWLVRQH��K\GURFRUWLVRQH��7�3UR�Supporting agents: Peptide Bioregulators, Cobalt chloride, DIM-Pro2™, GHRP2, GHRP6, sermorelin

HRT (hormone replacement therapy for women)Cobalt chloride, Esnatri™, HRT Plus®, melatonin, progesterone

Human growth hormone (see growth hormone)

Hydrogen Active H-minus®, ZeoGold Enhanced®

Hypertension (see blood pressure)

Immune system improvement (also see infections)1st Line™, ATP-Boost™, Beyond B12®, L-carnosine, maca, melatonin, Peptide Bioregulator- thymus (Vladonix®), Peptide Bioregulator- thyroid (Thyreogen®), pyritinol, Resveratrol-Pro™, thymus, thyroid

Infections (also see immune system improvement, anti-biotics & influenzas)

�VW�/LQH��ÀXFRQD]ROH��VLOYHU�SURWHLQ��:REHQ]\P�

Inflammation (reduction)Beyond Chelation Improved®, Bio-En’R-Gy®, Boluoke®, CurcuminSR™, Digestif®, Dr. Gordon’s organic greens®, NULOO��PDFD��SUHJQHQRORQH��WK\PXV��:REHQ]\P�

Influenzas (also see anti-biotics, infections & immune system improvement)

1st Line™

Injectable products&HUHEURO\VLQ��&URPDWRQELF��%��*HURYLWDO�+��

Insulin & glucose control (see diabetes)

Inter-nasal productsDesmopressin (Minirin®), MSH (MSH2-Pro™), oxytocin (Oxy-Pro™), GHRP6 (Releasing-Pro™), vasopressin (Vaso-Pro™), Vielight® laser

Intestinal flora (see probiotics)

Joints (also see bones & arthritis)Boluoke®, krill, Peptide Bioregulator- Sigumir®, 1RYLV\Q��SUHJQHQRORQH��6$0H��WK\PXV��:REHQ]\P�

Kidney disorders (also see infections)Aminoguanidine, Peptide Bioregulator - Pielotak®SAMe, TRH

Learning (also see memory & mental stimulants)Aniracetam, desmopressin, hydergine, piracetam, pramiracetam, vasopressin



Libido (see sex)

Lipids (see blood disorders)

Liver disorders (also see infections)CoQ10, Idebenone, Peptide Bioregulator- Svetinorm®, pregnenolone, SAMe, silver protein

Longevity enhancement (significant lifespan increases seen in animal studies)

Centrophenoxine, deprenyl, Desmopressin, melatonin

Lou Gehrig (ALS)Naltrexone, TRH

LungsACF228™ Breathe-Easy, Centrophenoxine, Nitric-Pro™, Peptide Bioregulator - Taxorest®, PulmoLife®

LupusMilnacipran, naltrexone

Lyme’s1st Line™, silver protein

Macular degeneration (see ARMD & eyesight)

Malaria (also see anti-biotics)

Memory (also see cognitive & senile dementia)*HQHUDO�VXSSRUW��.ULOO��SLFDPLORQH��YLQSRFHWLQHImprinting (for later recall): Desmopressin, vasopressinMedium-long term: Hydergine, phosphatidylserineShort term: Aniracetam, piracetam, pramiracetamSpeed of recall: Centrophenoxine, pyritinol

Menopause (see HRT)

Mental stimulants (also see physical stimulants)$GUD¿QLO��DQLUDFHWDP��FHQWURSKHQR[LQH��GHSUHQ\O��desmopressin, nicergoline, picamilone, piracetam, pramiracetam, vasopressin, Xan-Pro™

Methylation (conversion of one chemical into another inside the body)

ATP-Boost™, Beyond B12® Bio-En’R-Gy®, Boluoke®, 6$0H��:REHQ]\P��;DQ�3UR�

Migraines (also see pain relief)Beyond B12®, nicergoline, memantine, picamilone, Quinton®

Minerals (including trace- also see vitamins)Beyond Chelation Improved®, Bone-Pro2™, Gamalate®, Quinton®

Mitochondrial supportATP-Boost™, CoQ10, deprenyl, glutathione, hydergine, idebenone, PQQ, pregnenolone, SAMe

Multiple Sclerosis (also see mitochondrial support)Melatonin, naltrexone, TRH

Nail condition*HURYLWDO�+��NULOO

Narcolepsy (sleeping in the daytime)$GUD¿QLO��PHODWRQLQ��SLFDPLORQH

Nitric Oxide release

Nitric-Pro™, Neo40®, Nitric Oxide saliva test strips

Oral health care (see teeth & gums)

Osteoporosis (see bone problems)

Pain relief$73�%RRVW��*HURYLWDO�+��PHPDQWLQH��PLOQDFLSUDQ��QLFHUJROLQH��R[\WRFLQ��:REHQ]\P�

Parasites (see infections)

Parkinson’s disease (see senile dementia)

Peptides-short chain peptide bioregulatorsAdrenals = Glandokort®, Bladder = Chitomur®Blood vessels = Ventfort®, Bone marrow = Bonomarlot®Brain (CNS) = Cerluten®, Cartilage = Sigumir®+HDUW� �&KHORKDUW��.LGQH\� �3LHORWDN��Liver = Svetinorm®, Lungs = Taxorest®Muscle = Gotratix®, Ovaries = Zhenoluten®Pancreas = Suprefort®, Parathyroid = Bobothyrk®Pineal = Endoluten®, Prostate = Libidon®Retina = Visoluten®, Stomach = Stamakort®Testes = Testoluten®, Thymus = Vladonix®Thyroid = Thyreogen®

-other peptidesCerebrolysin®, GHRP2 (GHRP2-Pro™), GHRP6 (Releasing-Pro™)Sermorelin (Serm-Pro™), TRH (Abaris™)

Pets (see Animal use)

Ph balance (rebalancing)Active H-minus®, Dr. Gordon’s organic greens®, Quinton®

Photoaging (see radiation & skin problems)

Physical energy improvement (also see mental stimulants)

Active H-minus®, ATP-Boost™, Beyond B12®, CoQ10, idebenone, L-carnosine, maca, PQQ, pregnenolone, SAMe, yohimbine

PMS (pre-menstrual syndrome)Beyond B12®, krill, HRT Plus®, maca, Peptide Bioregulator - Zhenoluten®, vinpocetine

Premature ejaculation/ ejaculate (also see erectile dysfunction & sex-libido)

Oxytocin

ProbioticsBeyond Fiber®, Digestif®, Dr. Gordon’s organic greens®, Quinton®

Prostate (also see cancer)%H\RQG�%��'��',0�3UR��GXWDVWHULGH��¿QDVWHULGH��HRT Plus®, melatonin, Peptide Bioregulators - Chitomur® & Libidon®, Prostate-Pro2™

Prolactin alterationBromocriptine, cabergoline, GABOB, Gamalate®

PSA (prostate specific antigen- see prostate)

Radiation (see skin problems)

RNA (see DNA support)

Senile dementia (also see cognitive & memory)$O]KHLPHU¶V��&HQWURSKHQR[LQH��&XUFXPLQ65��galantamine, hydergine, memantine, nicergolineGeneral support: Anacervix®, aniracetam, piracetam, SUDPLUDFHWDP��YLQSRFHWLQH��:REHQ]\P�Parkinson’s: Bromocriptine, cabergoline, deprenyl, rasagiline

Senility *HURYLWDO�+��

Sex (libido, also see erectile dysfunction & premature ejaculation)

Andro-Pro™, deprenyl, maca, MSH, oxytocin, yohimbine

Skin problems (also see tanning)Age: (liver) spots: CentrophenoxineAnti-glycation: Aminoguanidine, L-carnosineAnti-oxidant: Crème-Pro™ ProtectorCancer (non-melanoma): BEC5® CuradermCellulite: Crème-Pro™ CellulessCollagen: Hy-Col™Environmental: Crème-Pro™ ProtectorFine lines: Crème-Pro™ Smoother*HQHUDO�VXSSRUW��*HURYLWDO�+��4XLQWRQ��WK\URLGHyaluronic acid: Hy-Col™Infections: Silver protein, Thym-Uvocal®0RLVWXUL]HU��&UqPH�3UR��0RLVWXUL]HU�Radiation: Crème-Pro™ Protector, melatonin6FDUV��VWUHWFK�PDUNV��7DPDQX�RLOSun spots: BEC5® CuradermWrinkles: Retin-A®

Sleep disorders)RU�OHVV�VOHHS��DGUD¿QLO��$73�%RRVW�For more sleep: 5HTP, gabapentin, L-tryptophan, melatonin

Smoking cessation 5HTP

Spine Issues Peptide Bioregulator- cartilage (Sigumir®), Novisyn®

Sports (see growth hormone, estrogen alteration, physical energy & testosterone)

Stress (also see cortisol)�+73��*$%2%��*DPDODWH��*HURYLWDO�+��PDFD��L-tryptophan, melatonin, oxytocin, picamilone, phenytoin, propranolol, pregnenolone

Stroke Anacervix®, aniracetam, Boluoke®, hydergine, idebenone, nicergoline, Nitric-Pro™, picamilone, piracetam, PQQ, pramiracetam, pregnenolone, vinpocetine

Stomach (see digestive)

Sublingual products Beyond B12™, Oxytocin (Oxy-Sub™), Sermorelin (Serm-Pro™)

Sunburn (see radiation)

Syndrome X (metabolic syndrome)Aminoguanidine, ATP-Boost™, krill, melatonin, metformin

Tanning (darkening the coloration of skin)MSH

Teeth & gum disorders'R[\F\FOLQH��1H\'HQW��VLOYHU�SURWHLQ��4XLQWRQ��]HROLWH

Telomeres (also see DNA support).ULOO��/�FDUQRVLQH��7$��

Testosterone & testes (also see fertility and prostate)$QGUR�3UR��$QDVWUR]ROH��$ULPLGH[��%H\RQG�%��Beyond GHS®, DIM-Pro2™, melatonin, oxytocin, Peptide Bioregulator - Testoluten®, TRH

Therapeutic equipment (see at-home therapeutics)

ThyroidsNatural brands: Armour®, ERFA®, West® (Nature®)6\QWKHWLF�EUDQGV��,%6$��7��7��(XWLUR[��7��7LURPHO��7��Supporting agents: Peptide Bioregulator - Thyreogen®

Travel (see frequent fliers)

Triglycerides (see blood disorders)

Urination (frequent)Peptide Bioregulator -Chitomur®, vasopressin

Veterinarian (see animal use)

Vitamins (also see minerals)Benfotiamine, Beyond B12®, Beyond Chelation ,PSURYHG��%LR��(Q¶5�*\�&��&R4��'��*$%2%��Gamalate®, Nitric Pro™, PQQ, pyridoxamine, Xan-Pro™

WaterActive H-minus®, Quinton®

Weight gain (muscle mass)Andro-Pro™, Beyond GHS®, GABOB, GHRP6, sermorelin

Weight loss (Appetite suppressants and diet aids)5HTP, acarbose, aminoguanidine, ATP-Boost™, benfotiamine, Beyond Fiber®, DIM-Pro2™, Dr. Gordon’s organic greens®, galantamine, GHRP2, L-tryptophan, metformin, MSH2, thyroid, TRH, Xan-Pro™

Well-being (also see depression)5HTP, Active H-minus®, aniracetam, ATP-Boost™, %H\RQG�%��GHSUHQ\O��*DPDODWH��*HURYLWDO�+��krill, L-tryptophan, melatonin, picamilone, piracetam, SUDPLUDFHWDP��6$0H��WK\PXV��WK\URLG��:REHQ]\P��ZeoGold Enhanced®


1. RegisteringThe first step is to become a member of the Paybyvoucher.com website. Registration is free with no monthly or annual charges levied against your account. Please be aware that Pay By Voucher

may request certain documents from you for verification purposes.

To successfully complete registration you have to confirm a One Time Pin (OTP) on the registration confirmation page. This pin will be sent to your mobile phone, so please make sure that you supply a valid mobile phone number.

Important things to remember

You should only set up one account with Pay By Voucher per email address or it causes a flag. If you have trouble, use the Pay By Voucher chat or customer service to get assistance, rather than just try to create a new account.

2. Register your credit cardFor security reasons Pay By Voucher require you to register your Credit Card. Once your Credit Card is registered every purchase is directly debited against your card.

Once registration is complete, you can start transacting.


Paybyvoucher comply with the Card Association regulations and your CVV number is not recorded and/or stored on their database. You will have to supply the CVV number every time you make a purchase on Paybyvoucher.

The CVV is the digits on the back of your credit card.

3. Buying vouchersCreate your own value voucher by using the buy vouchers link and entering the value you require and submitting your request .

There is also the option to buy one of the pre-set amount vouchers but vouchers must be purchased to the specific value of the transaction otherwise the transaction cannot be successfully processed.

Select a merchant category - it is compulsory to select the type of merchant where the voucher will be redeemed as payment

A 36-bit unique voucher pin will then be sent to your mobile phone or email. Please copy and paste this PIN from Pay By Voucher to antiaging-systems.com. If typed you could make errors and the voucher will not process.


• You should redeem vouchers bought from Pay By Voucher under the same name to your own sale on antiaging-systems.com. Mismatches in the name will cause flags and failed transactions.

• The country of Address and IP of the customer must match to the issuing bank of your card and the address you are using with you.

Purchased vouchers are also viewable in your Paybyvoucher.com account. Once a voucher is successfully redeemed on antiaging-systems.com the voucher will disappear from your account. If a voucher is only partially redeemed, the voucher will remain active in your user account for the remaining available balance.

We hope you find the guide helpful and can successfully process your transaction with us.

How to order from IAS: We accept Visa, MasterCard (via

voucher), echecks and Bank Wires.We accept PayPal on Antiaging Nutrition, Antiaging Nootropics and IAS Japan websites.

Using Pay By Voucher - How it works...

MailUnfortunately personal cheques and money orders cannot be accepted at present. Please contact our Customer Services Team for more information or assistance in placing your order.

InternetUSA & world

UK/ EUJapan

www.antiaging-systems.comwww.antiaging-nootropics.comwww.antiaging-nutrition.comwww.japanias.com

EmailUSA & world

[email protected]@antiaging-systems.com

PhoneUSA

JapanEU & world

UKSkype

1-866 800 4677 (orders only)1-415 992 5563 (enquiries)050 55 329606+44 208 123 21060208 123 2106antiaging-systems.comFax

USAJapan

EU & worldUK

1-415 366 15030367 40 7800+44 208 181 61060208 181 6106


If you want to buy nutrition and nootropics from IAS but pay with Mastercard or PayPal visit our brand new websites:

ANTIAGING NOOTROPICSFeaturing a range of bestselling smart drugs including Piracetam, Pramiracetam and Centrophenoxine, plus articles and a specifi c blog for nootropics.

www.antiaging-nootropics.com

ANTIAGING NUTRITIONFeaturing our entire range of ground breaking nutritional approaches to antiaging, including Can-C eye drops, Peptide bioregulators and TA65, plus articles, videos and a brand new blog.

www.antiaging-nutrition.com

YOUR VOUCHER CAN BE USED IN THE FOLLOWING WAYS:

NEW TO IAS GROUP?

Terms & conditions: This voucher entitles you to 10% off your order. There is no minimum spend. Voucher can only be used once in a single transaction. Off er excludes delivery costs, gift vouchers and cannot be used in conjunction with other vouchers and special off ers. We reserve the right to withdraw, amend or extend this off er at any time, without notice. This voucher cannot be exchanged for cash and if a purchase is made for a lower amount, no charge can be given. For standard terms and conditions please see our website. IAS Group, PO Box 19, Sark, GY9 0SB, Great Britain

Plus as a special introductory offer, get:

10%OFFYour fi rst order from:www.antiaging-nootropics.comwww.antiaging-nutrition.com

OFFER CODE: AM10%Offer end date: December 12th 2014

www.antiaging-nootropics.com1. When you have selected all your items, go to the shopping cart2. Enter you OFFER CODE in the Discount Codes box and click ‘Apply Coupon’

www.antiaging-nutrition.com1. When you have selected all your items, go to the shopping cart2. Enter you OFFER CODE in the Discount Codes box and click ‘Apply Coupon’

10% On the cutting edge

www.antiaging-nutrition.com • Order Hotline 1-866-800-4677

SPECIAL

INTRODUCTORY OFFER

OFF

If you want to buy nutrition and nootropics from IAS but pay with Mastercard or PayPal visit our brand new websites:

ANTIAGING NOOTROPICSFeaturing a range of bestselling smart drugs including Piracetam, Pramiracetam and Centrophenoxine, plus articles and a specifi c blog for nootropics.

www.antiaging-nootropics.com

ANTIAGING NUTRITIONFeaturing our entire range of ground breaking nutritional approaches to antiaging, including Can-C eye drops, Peptide bioregulators and TA65, plus articles, videos and a brand new blog.

www.antiaging-nutrition.com

YOUR VOUCHER CAN BE USED IN THE FOLLOWING WAYS:

NEW TO IAS GROUP?

Terms & conditions: This voucher entitles you to 10% off your order. There is no minimum spend. Voucher can only be used once in a single transaction. Off er excludes delivery costs, gift vouchers and cannot be used in conjunction with other vouchers and special off ers. We reserve the right to withdraw, amend or extend this off er at any time, without notice. This voucher cannot be exchanged for cash and if a purchase is made for a lower amount, no charge can be given. For standard terms and conditions please see our website. IAS Group, PO Box 19, Sark, GY9 0SB, Great Britain

Plus as a special introductory offer, get:

10%OFFYour fi rst order from:www.antiaging-nootropics.comwww.antiaging-nutrition.com

OFFER CODE: AM10%Offer end date: December 12th 2014

www.antiaging-nootropics.com1. When you have selected all your items, go to the shopping cart2. Enter you OFFER CODE in the Discount Codes box and click ‘Apply Coupon’

www.antiaging-nutrition.com1. When you have selected all your items, go to the shopping cart2. Enter you OFFER CODE in the Discount Codes box and click ‘Apply Coupon’

10% On the cutting edge

www.antiaging-nutrition.com • Order Hotline 1-866-800-4677

SPECIAL

INTRODUCTORY OFFER

OFF

Adrenals (Glandokort®) 20x 200mg capsules $79.99

Bladder (Chitomur®) 20x 200mg capsules $79.99

Blood vessels (Ventfort®) 20x 200mg capsules $79.99

Brain (Cerluten®) 20x 200mg capsules $79.99

Cartilage (Sigumir®) 20x 200mg capsules $79.99

Eyesight (Visoluten®) 20x 200mg capsules $79.99

Heart (Chelohart®) 20x 200mg capsules $79.99

Kidneys (Pielotak®) 20x 200mg capsules $79.99

Liver (Svetinorm®) 20x 200mg capsules $79.99

Lungs (Taxorest®) 20x 200mg capsules $79.99

Muscle (Gotratix®) 20x 200mg capsules $79.99

Ovaries (Zhenoluten®) 20x 200mg capsules $79.99

Pancreas (Suprefort®) 20x 200mg capsules $79.99

Pineal (Endoluten®) 20x 200mg capsules $99.99

Prostate (Libidon®) 20x 200mg capsules $79.99

Stomach (Stamakort®) 20x 200mg capsules $79.99

Testes (Testoluten®) 20x 200mg capsules $79.99

Thymus (Vladonix®) 20x 200mg capsules $79.99

Thyroid (Thyreogen®) 20x 200mg capsules $79.99

PEPTIDE BIOREGULATORS

Harness your biological reserves

See www.antiaging-systems.com for much more information


Each organ, tissue or gland uses a specifi c short chain peptide to initiate protein synthesis. Each of the peptides in our extensive range are designed to interact with particular strands of DNA to repair and regenerate them.

We currently stock peptides for the following:

Off er: Save 15% when you buy 3 or more!

Documents

Aging Matters Issue 6, 2014