Aim: Comparative Evaluation of market brands; oral suspension

Requirement: beaker, pipette, Brookfield viscometer, test-tubes, UV-spectrophotometer.

References:

1. Leon lachman, Pharmaceutical dosage form: Disperse system, vol 2, page no

2. Indian Pharmacopoeia, 2007.

Marketed Formulations:

1. Calpol SuspensionContent: Paracetamol IP 120 mgVolume: 60 mlCompany: GlaxoSmithKline Ltd.

2. Zincal calamine lotionContent: Calamine lotion IP 15 gm Zinc Oxide IP 5 gm Bentonite IP 3 gm Glycerine IP 5 ml Sodium citrate 0.5 gm Liquid phenol IP 0.5 ml Purified water q.s. to 100 mlVolume: 100 mlCompany: Alive

Evaluation parameters:

1. Sedimentation Volume Ratio(SVR)2. Redispersibility3. Particle size distribution4. Viscosity5. Density6. Appearance

Observation:

1. Organoleptic characteristic:a. Color:b. Odour:c. Taste:

2. Redispersibility:

3. pH value:

4. Viscosity:

5. SVR

Suspension

Time (min)

Initial Height (H0)

Ultimate Height(Hu)

SVR Average SVR

Marketed preparation

Lab.preparation

Marketed preparation

Lab.preparation

Marketed preparation

Lab.preparation

Marketed preparation

Lab.preparation

Paracetamol suspension

0102030405060

Calamine lotion

0102030405060

7. Particle size distribution:A. Paracetamol suspention:

B .Calamine lotion:

7. Density:A. Paracetamol Suspention:

Initial weight of empty bottle W0 =Bottle + suspension W1 =Bottle capacity = 10 ml

Density = W1-W0

10

B. Calamine lotion:Initial weight of empty bottle W0 =Bottle + suspension W1 =Bottle capacity = 10 ml

Density = W1-W0

10

8. Paracetamol assay 5 ml paracetamol suspension was taken and diluted to 100 ml using

distilled water, add 50 ml of 0.1 M sodium hydroxide, dilute with 100 ml of water, shake for 15 minutes and add sufficient water to produce 200.0 ml. Mix, filter and dilute 10.0 ml of the filtrate to 100.0 ml with water. To 10.0 ml of the resulting solution add 10 ml of 0.1 M sodium hydroxide, dilute to 100.0 ml with water and mix.

Measure the absorbance of the resulting solution at the maximum at about 257 nm. Calculate the content of paracetamol taking 715 as the specific absorbance at 257 nm.

Result:

PARAMETER PCM (marketed)

PCM

CALAMINE(marketed) CALAMINE

RedispersibilitypH valueViscositySVRParticle size distribution

Density

Signature: