Clean air solutions

Sean O’Reilly Global Director Life Science Segment

Air Filtration Standards & Sustainability

Clean air solutions Clean air solutions Clean air solutions Clean air solutions

• HVAC Filter Types • Filter Efficiency • Energy Consumption Examples-LCC • Terminal Housings & Hepa testing • Hepa repair • BIBO Housings • HVAC & Hepa Standards • CREO (Clean room design Software)

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Camfil Group

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Air Filtration Technologies…

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04 Types of HEPA Filters...

Anodized Aluminum Frame

Galvaneal or Stainless Steel

Frame

Aluminum Separator

Gasket or Gel Seal

Polyurethane Sealant

Micro-fiberglass

HEPA media

Fiberglass or Thermoplastic Separator with

adhesive

Box-type HEPA Panel-type HEPA

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The energy cost of ventilation (simplified)

Air Handling Unit

Pre-filter Secondary-filter

Air intake

Inlet duct Distribution duct

Room distribution grille

Damper

Cooling coil Heating coil

FAN

MOTOR

Air supply

Molecular-filter

Noise attenuation

OUTSIDE INSIDE

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LCC - the increased cost of energy

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Filter Cost

Labor Cost

Disposal Cost

Cleaning Cost

Energy Cost

Typically 60-80% of the LCC of a filter is the energy consumption.

What if we gave you free filters in exchange for 50% of your Energy savings?

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04 Field Efficiency; Real Life Testing...

• MERV 13, fine fiber media

• MERV 13, coarse fiber media

• MERV 11, fine fiber media

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60

70

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0 500 1000 1500 2000 2500 3000 3500 4000 4500 5000

Efficiency at 0.4 um (%)

Life Time (h)

Apples to Apples in efficiency when doing an LCC analysis

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MERV 14/F8 Filter

Outside Air 1,500,000

Particles/ft3

Room Counts 420,000 Particles/ft3

Penetration

72% @ 0.3µm

72% @ 0.3µm

25% @ 0.3µm

Room Counts 1,125,000 Particles/ft3

Coarse Fiber Media (Same type media used at Wyeth,

prior to Camfil Farr)

Camfil Durafil Fine Fiber Media

How does efficiency work...

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extraordinary Sales Tools

LCC & TCO Support Tools

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LCC = Investment + PCenergy + PCmaint. + PCcleaning + PCdisposal

• Investment – capital cost of filters, frames, installation

• PCenergy – present total cost of power

• PCmaintenance – present total cost of maintenance including filter replacement, etc.

• PCcleaning – present cost of duct cleaning

• PCdisposal – present total cost for removal and disposal of the used filters

components of Life-Cycle Cost

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• PCEnergy – the current cost of energy Energy (E) = [(Q * ΔP * T)/(ŋ * Co)] * Pc

Q – Air flow, m3/s (cfm) ΔP – Average filter pressure loss, Pa (inWG)

T – Operation time, hr

ŋ – Fan efficiency, % Co – Constant, 1000 in SI units, 8515 in IP units

Pc – Cost of Power, $/kWh

energy equation for life-cycle cost

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Camfil Design vs. “Copy me” Design

Chandler or ‘V” type pleat will blind causing rapid increase in pressure drop.

Uniform radial style pleat loads evenly resulting, in lower

average pressure drop and long loading curve.

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… and a Performance Comparison

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• Easily compare stage by stage • Complete LCC cost graph • Includes all LCC reports and charts • Writes a conclusion and recommendation for

you • Includes the explanations needed most…

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Camfield Mobile Lab

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Background to cleanroom ventilation

Class 100 / ISO5 Class 10,000 / ISO7 & 100,000 / ISO8

Particles displaced

Particles diluted

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Turbulent cleanroom ventilation – a component of contamination control

Clean air supply should dilute any residual particles shed from people and other emission sources and then be removed by the extract

system

Ventilation effectiveness defines how good the system is at diluting

contamination – and hence how much air is needed

(ac/hr)

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Ventilation Effectiveness – key to successful contamination dilution Typical USA

Air can also bounce off the floor and

entrain contaminants

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Ventilation Effectiveness – key to successful contamination dilution Typical EU/Asia

Cleaning could also be a concern

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Pharmaseal G Standard for Life Science applications.

Typical Model - 80% of Install Base

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Fully Equipped for GMP In situ Controls Integrated Aerosol Dispersion Ring

Immediate access from room-side

100% Sampling Port Aerosol Injection Port

Hinged Grille Quick closing with

¼ Turn Fasteners

PAO Test Pressure Drop Airflow Velocity

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Pharmaseal: Long Term Security

Airtight by Design Fully continuous welded. Airtight continuity with clean room ceiling with permanent

trim standard design. “Universal Knife Edge” Housing

Silicon gel (recommended). Immediate seal without mechanical strength. Gel belongs to filter.

Expanded PU Gasket possible.

No Risks for Leaks During Life Cycle

Cleanroom False Ceiling

Gel Expanded PU

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1. aerosol particle size – different aerosols – different generation techniques

2. aerosol concentration – different generation techniques – generator input conditions – volume flow rate through filter

3. filtering velocity – system conditions

factors influencing filter penetration

LEAKS

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99.988

99.990

99.992

99.994

99.996

99.998

100.000

0.01 0.1 1

Effic

iency

%

Particle Size (µm)

Example performance of a HEPA Filter

Viruses Bacteria Droplet Nuclei

HEPA filters should be tested at the Most Penetrating Particle Size (MPPS)

MPPS (0.16-0.2 micron)

0.3 micron

0.12 micron

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Room-Side Certification

Aerosol Dispersion Ring:

PAO test performed in compliance with ISO-IEST standards.

NO PAO IN HVAC DUCTING for fire safety & increased filter life.

Control Panel - Centralized & Ergonomic: Injection + control from room-side

requiring only 1 person to test filter.

Quick plus airtight connection using the quick disconnect ports.

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How & where to use aerosol injection is often overlooked during the design process…

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3

4

Why is Room-Side Certification Important?

What location should aerosol be introduced? What type of terminal housing should an owner

or engineer select & why?

AHU Injection? 1 Ductwork Injection? 2 Hood Injection? 3

4 RA Injection?

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How to Test a WM Pharmaseal ?

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Price

Customer Value BSL 1

BSL/Pharma BSL/Pharma/Nuclear G

BSL/Pharma/Nuclear

No test

NI EFF/ NI Manual Scan

CamBox

CamSafe

CamContain CS NI Auto Scanning

NI Auto Scanning CamContain C CamContain CL

NI EFF /NI Maual Scan

Products for Bio Safety / Life Science:

BSL 2 BSL 2+3 BSL 3 BSL 3+4

Pharmatain

Camtain BIBO DC

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Current Standards-IEST (Cont.);

Type E-AG1 Type K-Recommended for 0.01% leak test with thermal PAO

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Current Standards – EN1822 (Cont);

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New Standard 2012; ISO -29463 parts 1 thru 5

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Updated Cleanroom Filter Standards:

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Updated Cleanroom Standards:

• Simplify the classification process and if possible remove the need to evaluate the 95% UCL for 2-9 sample locations

• Review the classification procedure and make it more applicable to rooms in operation. The contamination isn’t expected to be evenly distributed an assumption the current statistical approach makes.

• Avoid any radical changes to the principals of the current ISO cleanliness classes 1-9

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HVAC Global Air Filter Standards

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CREO a new CleanRoom design & Energy Optimization software.

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