Upload
sainzb83
View
174
Download
11
Tags:
Embed Size (px)
Citation preview
Air Handling Systems
Heating Ventilation and Air Conditioning (HVAC)
Part 2: Components
Supplementary Training Modules on GMP
Module 3, Part 2: Components Slide 1 of 20 WHO - EDM
Module 3, Part 2: Components Slide 2 of 20 WHO - EDM
Air Handling Systems
Purpose of an air handling system
Air Handling System
Production RoomWith
DefinedRequirements
SupplyAir
OutletAir
Module 3, Part 2: Components Slide 3 of 20 WHO - EDM
Air Handling Systems
Objectives
In the following slides, we will study the components of air handling systems in order to:
1. become familiar with the components
2. know their functions
3. become aware of possible problems
Module 3, Part 2: Components Slide 4 of 20 WHO - EDM
Air Handling Systems
+
Production Room
Exhaust air treatment
Central air handling unit
Terminal air treatmentat production room level
Fresh air treatment (make-up air)
Main subsystems
Module 3, Part 2: Components Slide 5 of 20 WHO - EDM
Air Handling Systems
FilterSilencer
Terminal filter
Weather louvre Control damper
FanFlow rate controller
Humidifier
Heating coil
Cooling coil with droplet
separator
Production Room
Overview components
+
Prefilter
Exhaust Air Grille
Heater
Secondary Filter
Re-circulated air
Module 3, Part 2: Components Slide 6 of 20 WHO - EDM
Air Handling Systems
Weather louvre
Silencer
Flow rate controller
Control damper
To prevent insects, leaves, dirt and rain from entering
To reduce noise caused by air circulation
Automated adjustment of volume of air (night and day, pressure control)
Fixed adjustment of volume of air
Components (1)
Module 3, Part 2: Components Slide 7 of 20 WHO - EDM
Air Handling Systems
Heating unit Cooling unit /dehumidifier
Humidifier
Filters
Ducts
To heat the air to the proper temperature
To cool the air to the required temperature or to remove moisture from the air
To bring the air to the proper humidity, if too low
To eliminate particles of pre-determined dimensions and/or micro-organisms
To transport the air
Components (2)
Module 3, Part 2: Components Slide 8 of 20 WHO - EDM
Air Handling Systems
Flow rate controller
Control damper
Humidifier
Cooling battery
Filters
Ducts
Blocked
Poorly adjusted, bad pressure differential system
Bad water/steam quality/poor drainage
No elimination of condensed water/poor drainage
Incorrect retention rate/damaged/badly installed
Inappropriate material/internal insulatorleaking
Problems with components
Module 3, Part 2: Components Slide 9 of 20 WHO - EDM
Air Handling Systems
+
Production Room
Exhaust air
Return air(re-circulated)
Fresh air(make-up air)
Supply air
Air types
Module 3, Part 2: Components Slide 10 of 20 WHO - EDM
Air Handling Systems
Particles / m3
? 0.5µm
US 209Dnon-
metric
US 209E1992
metric
EC cGMPAnnex I1997
GermanyVDI 20831990
UKBS 52951989
J apanJ IS B 9920
1989
ISO 14644-1
13,5 0 2 210 M 135 1 M 1.5 1 3 3
100 M 2353 10 M 2.5 2 4 4
1.000 M 33.530 100 M 3.5 A, B
A= unidirectionalB= turbulent
3 E or F 5 5
10.000 M 435.300 1.000 M 4.5 4 G or H 6 6
100.000 M 5353.000 10.000 M 5.5 C 5 J 7 7
1.000.000 M 63.530.000 100.000 M 6.5 D 6 K 8 8
10.000.000 M 7
Comparing International Cleanroom Classifications
Module 3, Part 2: Components Slide 11 of 20 WHO - EDM
Air Handling Systems
Filter classesDust filters
Standard Aerosol
FineCoarse ULPAHEPA
10 µ m > Dp > 1 µ mDp > 10 µ m Dp < 1 µ m
F5 - F9G1 - G4 U 14- 17H 11 - 13
EN 1822 StandardEN 779 Standard
Module 3, Part 2: Components Slide 12 of 20 WHO - EDM
Air Handling Systems
Average EfficiencyIntegral Value
Peak ArrestanceLocal Value
Retention in%
Penetration Efficiency Penetration
F9 85 0.15
H11 95 0.05
H12 99.5 5x10-3 97.5 25x10-3
H13 99.95 5x10-4 99.75 25x10-4
U14 99.995 5x10-5 99.975 25x10-5
Classification of filters according to their efficiency
Module 3, Part 2: Components Slide 13 of 20 WHO - EDM
Air Handling Systems
Primary panel filter
Secondary filter
HEPA or tertiaary filter
Module 3, Part 2: Components Slide 14 of 20 WHO - EDM
Air Handling Systems Humidifier Silencer Heating and cooling units
Module 3, Part 2: Components Slide 15 of 20 WHO - EDM
Air Handling Systems
Control damper for air flow
De-humidification
Filter Pressure Gauges
AHU with fan Variable Speed Controller
Humid room air
Air heater
Regeneration air
Humid room airAdsorber wheel Dry air
Air handling unit
Module 3, Part 2: Components Slide 16 of 20 WHO - EDM
Air Handling Systems
Swirl Type air diffusors with terminal filters1 Filter
2 Tightening frame3 Register outlet4 Screw fixation for register
1
2
3
4
Module 3, Part 2: Components Slide 17 of 20 WHO - EDM
Air Handling Systems
Low induction swirl diffusor(preferred)
High induction office type diffusor
(avoid)
Module 3, Part 2: Components Slide 18 of 20 WHO - EDM
Air Handling Systems
Annex 1, 17.26
Regulation of room pressure – pressure differentials concept
Room pressure gauges
Room pressure indication panel
Module 3, Part 2: Components Slide 19 of 20 WHO - EDM
Air Handling SystemsPressure cascade injectables
Protection from micro-organisms and particles
Note : Direction of door opening relative to room pressure
15 Pa
0 PaAirLock
30 Pa PassageD
C
A
B
D LF
Air LockAir Lock45 Pa
Room 3 Room 2 Room 1
45 Pa60 Pa30 Pa
Annex 1, 17.24, 17.25
Module 3, Part 2: Components Slide 20 of 20 WHO - EDM
Air Handling Systems
Pressure cascade solidsProtection from cross-contamination
Note : Direction of door opening relative to room pressure15 Pa15 Pa15 PaE30 PaPassage0 PaAirLock Room 3 Room 2 Room 115 PaAir LockAir Lock
Note : Direction of door opening relative to room pressure
15 Pa
15 Pa15 Pa
E30 Pa
Passage0 Pa
AirLock
Room 3 Room 2 Room 1
15 Pa
Air LockAir Lock