ALAN P. KORETSKY

Laboratory of Functional and Molecular Imaging National Institutes of Neurological Disorders and Stroke

Bethesda, MD 20892 (301) 402-9659

koretskya@ninds.nih.gov Education:

Staff Fellow (Postdoctoral), National Institutes of Health, Bethesda, MD. 1985-86. Ph.D. Biophysical Chemistry, University of California, Berkeley, CA. December, 1984. M.S. Chemistry, University of California, Berkeley, CA. June, 1980. B.S. Chemistry, Massachusetts Institute of Technology, Cambridge, MA. June, 1978.

Research/Professional Experience:

Research Assistant, Harvard Medical School, Cambridge, MA. Physical-chemical studies of biological molecules important to the function of bile (1976-78). Advisor: M.C. Carey Teaching Assistant, Department of Chemistry, University of California, Berkeley, CA. (1979-80). Research Assistant, Lawrence Berkeley Laboratory, University of California, Berkeley, CA. Applications of NMR to studies of phospholipids in model membranes (1979-80). Advisor: M.P. Klein Lecturer, Department of Chemistry, Mills College, Oakland, CA. Taught senior biochemistry (1981). Research Assistant, Veterans Administration Medical Center, University of California, San Francisco, CA. Applications of NMR to studies of metabolism in intact tissue (1981-85). Advisors: M.W. Weiner, M.P. Klein, and T.L. James. Staff Fellow, National Institutes of Health, Bethesda, MD. Applications of fluorescence and NMR to bioenergetics (1985-86). Advisor: R.S. Balaban Assistant Professor, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA. (March, 1987-May, 1992). Associate Professor, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA. (June, 1992-April, 1999) Visiting Scientist, Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA (July, 1994- July, 1995) Sabbatical leave in the laboratory of R. Jaenisch.

Professor, Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, PA (May, 1999) Chief, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD (June, 1999-present). Director, NIH MRI Research Facility/Mouse Imaging Facility, National Institute of Neurological Disorders and Stroke, NIH, Bethesda, MD (June 1999-present). Scientific Director, Intramural Research Program, NINDS, NIH, Bethesda, MD (Oct. 2006-present).

Invited Talks at Meetings and Symposia: 1) Society of Magnetic Resonance in Medicine, August, 1984, New York, N.Y. 2) Joint US-USSR Symposium on Heart and Lung Metabolism, Sept. 1987, Ashville, N.C. 3) NMR: The Principles and Applications of NMR Spectroscopy and Imaging to Biomedical

Research, Continuing Education Program, University of Pittsburgh, Nov. 1987, Pittsburgh, PA.

4) Mid-Atlantic Regional Meeting of the American Chemical Society, May, 1988, Lancaster,

PA. 5) XII Int. Conference on Magnetic Resonance in Biological Systems, Aug. 1988, Madison, WI. 6) Society of Analytical Chemists of Pittsburgh Symposium on NMR and MR Imaging,

Duquesne University, Pittburgh, PA. Nov. 1988. 7) Chaired Session on "Heart and Skeletal Muscle Spectroscopy." Society of Magnetic

Resonance in Medicine. New York, NY. Aug. 1990 8) Bruker Users Conference. Boston, MA. Oct. 1990. 9) AAAS Meeting on Funding and Morale in Academic Research. Washington, D.C. Jan. 1991. 10) Workshop on in vivo Magnetic Resonance Spectroscopy. St. Louis, MO. April, 1991.

Plenary Speaker. 11) Annual Meeting of American Society of Biochemistry and Molecular Biology. Atlanta, GA.

April, 1991. 12) Biochemical Society Meeting. Manchester, England. July, 1991. 13) Chaired Session on "Heart and Skeletal Muscle Spectroscopy." Society of Magnetic

Resonance in Medicine. San Francisco, CA. Aug. 1991.

14) International Symposium and Workshop on Structural Biology, Institute of Biomedical Sciences, Academica Sinica, Taipei, Taiwan. Jan. 1992.

15) National Heart, Lung, and Blood Institute. NIH. Symposium on Magnetic Resonance

Imaging and Spectroscopy at High Magentic Fields in vivo. June, 1992. 16) XIV Int. Conference on Magnetic Resonance in Biological Sciences, Jerusalem, Israel, Aug.

1992. 17) Chaired Session on "Whole Body Localized Spectroscopy". XIV Int. Conference on

Magnetic Resonance in Biological Sciences, Jerusalem, Israel, Aug. 1992. 18) National Cancer Institute Consensus Conference. Quantitative Evaluation of Tissue Function

with Contrast-Enhanced MRI", Bethesda, MD. April, 1993. 19) Functional MRI of the Brain: A Workshop presented by the Society of Magnetic Resonance

in Medicine and the Society for Magnetic Resonance Imaging, Arlington, Va. June, 1993. 20) Princeton Conference on Stroke. Boston, MA. March, 1994. 21) American Thoracic Society Symposium entitled "Advances in the Study of the Cellular and

Molecular Biology of Skeletal Muscle: New Tools for Respiratory Muscle Research". American Thoracic Society Meeting, Boston, MA. May, 1994.

22) Chaired Session on "MRI of Animal Brain". Second Annual meeting of Society of Magnetic

Resonance, San Francisco, CA. August, 1994. 23) Workshop on "Advances in Physiological Chemistry by NMR", Woods Hole, MA, March,

1995. 24) Washington DC Area NMR Group, Bethesda, MD, May, 1995. 25) Symposium on Magnetic Resonance Microimaging, Annual Meeting Microscopy Society of

America, Kansas City, MO, August, 1995. 26) Brukers User Conference, NY, NY. April, 1996. 27) International Society of Magnetic Resonance in Medicine, Fourth Annual Meeting, NY, NY,

April, 1996, Plenary Speaker. 28) Ninth Conference of Magnetic Resonance in Biological Metabolism and Function, Kyoto

Prefectural University of Medicine, Kyoto, Japan, July, 1996, Plenary Speaker. 29) International Society of Magnetic Resonance in Medicine, Fifth Annual Meeting, Pre

Vancouver, BC, April, 1997. Categorical Symposium on Diffusion/Perfusion, Presented by Donald Williams.

30) Third International Symposium on Magnetic Resonance in Cardiovascular Research, Utrecht, Netherlands, Sept., 1997.

31) International Workshop on Perfusion Imaging: Quantitative Cerebral Blood Flow Mapping

in Humans Using Magnetic Resonance Imaging, National Institute of Mental Health, NIH. Bethesda, MD. October 20, 1997.

32) Symposium on the Forefronts of Imaging Technology, Health Sciences and Technology

Program, Harvard Medical School, Boston, MA. Nov. 24, 1997. 33) Symposium to Honor Ken Sauer and Mel Klein, Calvin Laboratory of Chemical

Biodynamics, University of California, Berkeley, CA. Jan. 7-8, 1998. 34) McDonnell Foundation Workshop on "Cerebral Metabolism and Functional

Neuroenergetics", Invited Participant, St. Louis, MO, May 20-21, 1998 35) Amyotrophic Lateral Schlerosis Association Workshop on "New NMR Science and ALS",

Warrenton, VA, May 21-22, 1998. 36) XVIII International Conference on Magnetic Resonance in Biological Systems, Tokyo,

Japan, August 24-28, 1998. 37) Second Annual Heart Failure Society Meeting, Boca Raton, Florida. Sept. 14-17, 1998. 38) Brain Awareness Week Symosium, "Neuroimaging: Glimpses into the Working Brain",

Sponsored by National Institute on Drug Abuse, NIH, Bethesda, MD, March 16, 1999. 39) Imaging the Pancreatic Beta Cell, Co-Sponsored by the National Institute of Diabetes and

Digestive and Kidney Diseases and the Juvenile Diabetes Foundation, Washington DC, April 19-20, 1999.

40) Workshop on Magnetic Resonance and Optical Imaging Techniques for Biomedical

Applications. A symposium to honor the 60th Birthday of John Leigh. Sponsored by Metabolic Magnetic Resonance Research and Computing Center, Department of Radiology, University of Pennsylvania, Philadelphia, PA. May 21-22, 1999.

41) Dynamic NMR Study Group, International Society of Magnetic Resonance in Medicine,

Philadelphia, PA, May 24, 1999. 42) Frontiers of Biomedical Science Symposium, Institute of Biomedical Sciences, Academia

Sinica, Taipei, Taiwan, July 9, 1999. 43) Zeugmatography and Beyond: A Special Tribute to Professor Paul C. Lauterbur on the

Occasion of his 70th Birthday, Beckman Institute for Advanced Sciences and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA, Sept. 17-18, 1999.

44) Imaging in 2020, Jackson Hole, WY, Sept. 26-30, 1999.

45) Modeling Human Mammary Cancer in Mice, Jackson Laboratories, Bar Harbor, ME, Oct 5-8, 1999.

46) Magnetic Resonance Imaging of Brain Function, Center for Magnetic Resonance Research,

University of Minnesota Medical School, Minneapolis, MN, Oct. 17-18, 1999. 47) International Society of Magnetic Resonance in Medicine, Eigth Annual Meeting, Denver,

CO., April 3-7, 2000. Plenary Speaker. 48) Stem Cells and Pancreatic Development Workshop, NIH, April 10-11, 2000. 49) First Annual Molecular Imaging Workshop, Department of Radiology, Michigan State

University, East Lansing, MI, July 14-15, 2000. 50) Chaired Session on Functional Genomics of the Mouse with MRI, Magnetic Resonance

Gordon Conference, New Hampshire, August 20-24, 2000. 51) Moderator, Sessions on “White Matter Fiber Tractography”, and “Structure and Architecture

of the Heart”, Diffusion Tensor MRI: From bench to Bedside Workshop, NIH, Dec. 2000. 52) Roundtable on “Research Opportunities in Functional Imaging of Soft Tissues”, NIAMS,

NIH, Jan, 31, 2001. 53) Categorical Course in Functional MRI, International Society of Magnetic Resonance in

Medicine, Glasgow, Scotland, April, 27, 2001. 54) NIH Bioengineering Consortium Symposium on Tissue Engineering, Bethesda, MD, June,

2001. 55) Experimental NMR Conference, Asilomar, CA, April 15, 2002. 56) Session on “Functional Anatomy: visualizing Genetics, Physiology, and Metabolism”,

American Association of Anatomists, Experimental Biology, New Orleans, April 23, 2002. 57) McGovern Institute for Brain Research Symposium, “New Approaches in Neuroscience”,

MIT, Cambridge, MA. May 13-14, 2002. 58) 8th International Conference on Functional Mapping of the Human Brain, Sendai, Japan,

June 2-6, 2002. Plenary Speaker. 59) IEEE International Symposium on Biomedical Imaging, Washington, DC, July 7-9, 2002.

Plenary Speaker. 60) Session on Contrast Optimization for Molecular Imaging and Genetic Expression. In Vivo

Magnetic Resonance Gordon Conference, New London, NH, July 28-Aug 2, 2002. 61) A Symposium on Imaging Alzheimer’s Disease, The Neurosciences Institute, Albany

Medical Center and GE Global Research Center, Niskayuna, NY, Sept. 13, 2002.

62) Systems Biology Approaches to Health Care: Mitochondrial Proteomics. National Institutes

of Standards, Gaithersburg, MD, Sept. 17-18, 2002. 63) Third Inter-Institute Workshop on Diagnostic Optical Imaging and Spectroscopy: the Clinical

Adventure. Bethesda, MD, Sept 26-27,2002. 64) Functional Imaging Symposium, Functional Neuroimaging Facility, Department of

Psychology, University of Alabama, Birmingham, AL, Nov. 8-9, 2002. 65) Functional Analysis of the Mouse Genome Symposium, Centre for Modeling Human

Disease, Mount Sinai Hospital, Toronto, Canada, Dec 12, 2002. 66) Non-Invasive Imaging Methods Applied to Small Animals. DFG Symposium, Wurzburg,

Germany, Feb. 1-12, 2003. 67) 5th Annual Meeting of the Society for Experimental Neurotherapeutics, Washington DC,

March 14, 2003. Plenary Session on Neuroprotection. 68) Forefront of Imaging Techniques in Clincial and Basic Sciences, Graduate Student

Colloquium and Faculty Senate Research Day, Uniformed Services University of the Health Sciences, Bethesda, MD, May 15, 2003.

69) Frontiers in Neuroimaging, VISN Meeting, San Antonio, TX, July 11, 2003. 70) MR of Transgenic Mouse Models, Educational Course, International Society of Magnetic

Resonance in Medicine, Toronto, Canada, 2003. Presented by Erik Shapiro. 71) Academy of Molecular Imaging, Institute of Molecular Imaging, HiRES, Annual meeting,

Madrid, Spain, Sept., 2003. Plenary Speaker.

72) NIBIB-DOE Workshop on Biomedical Imaging: Optical and X-ray Technologies, Bethesda, MD, Feb., 2004.

73) Gordon Research Conference on Brain Energy Metabolism and Blood Flow, Invited Speaker,

Colby College, ME, August 8-13, 2004. 74) Society of Molecular Imaging , Plenary Speaker, St. Louis, Mo., Sept 9-12, 2004. 75) International Society of Magnetic Resonance 15th Triannual Meeting , Ponte Verda Beach,

Fl, Oct 24-28, 2004. 76) University of Illinois, Beckman Institute, “Frontiers of Biomedical Imaging Symposium: The

MRI Nobel Celebration in honor of Paul Lauterbur and Future Directions”, Plenary Speaker, Nov 8-10, 2004.

77) Research Symposium on Basic and Clinical Applications of Functional and Molecular Neuroimaging, Center for Functional Neuroimaging, Departments of Radiology and

Neurology, University of Pennsylvania, Philadelphia, PA, Keynote Speaker, April 22, 2005.

78) Alzheimer's Association International Conference on Prevention of Dementia, Pre-Conference Course, Imaging Alzheimer's Disease with MRI and PET: A course for non-imagers, Washington, DC. June 18, 2005

79) Alzheimer's Association International Conference on Prevention of Dementia, Symposia on Imaging, Washington, DC, June 19, 2005.

80) High Field MR Imaging and Spectroscopy and Magnetic Resonance Imaging of Brain Function, Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, MN, Oct. 13-16, 2005.

81) International Symposium on Biomedical Magnetic Resonance Imaging and Spectroscopy at Very High Fields, University of Wurzburg, Wurzburg, Germany, Feb. 16-18, 2006.

82) PittCon 2006, Symposium on Biomedical Imaging: from Living Cells to Tissues to In Vivo Patient Diagnostics, Orlando, Fl, March 12-16, 2006.

83) Academy of Molecular Imaging, Society of Non-Invasive Drug Development, Symposium of Cell Tracking, Orlando, Fl, March 25-29, 2006.

84) Metals In Medicine Gordon Conference, Contrast Agent Session, Oxford, England, July 9-14, 2006.

85) EuroMar, Imaging Session, York, England, July 16-21, 2006. 86) Advanced Neuroimaging Symposium, National Taiwan University International

Neuroscience Symposium, Taipei, Taiwan, Dec. 9-10, 2006.

87) Imaging Long-Term Plastic Changes in Mental Processing: Development through Psychotherapy, The Ellison Medical Foundation, Rockerfeller University, NY, NY Feb. 5-6, 2007.

88) Medical Imaging Symposium, Molecular Imaging Center, Norwegian University of Science and Technology, Trondheim, Norway, Feb 16-17, 2007.

89) Small Animal MRI Symposium, Barrow Neurological Institute, Phoenix, Az, March 9, 2007. 90) Workshop on Advances in High Field MR, Pacific Grove, CA, March 25-28, 2007.

91) Human Brain Diseases: Neuroscience Update Symposium, Jointly Sponsored by the Florey

Neurosciences Institute, the Centre for Neuroscience, and the Mental Health Research Insitute, Melbourne, Australia, Plenary Speaker for Neuroimaging Session, Nov. 12-14, 2007.

92) Paul C. Lauterbur Memorial Symposium, Beckman Institute for Advanced Science and Technology, University of Illinois, Urbana-Champagne, March 26-March 28, 2008.

93) Cell and Molecular Imaging Workshop. McKnight Brain Institute, University of Florida, Gainesville, Fl. Keynote Speaker. Nov. 6, 2008.

94) SPIE Medical Imaging 2009, Biomedical Applications: Molecular, Structural and Functional Imaging, Keynote Speaker, Orlando, Fl, Feb 8-12, 2009

95) Experimental NMR Conference, Asilomar, CA. Invited Speaker for the 50th Anniversary meeting of the ENC. March 29-April 3, 2009.

96) Symposium on Recent Advances in Cellular and Molecular Imaging, Carnegie Mellon University and University of Pittsburgh, Pittsburgh, PA, April 3-4, 2009.

97) XXIVth International Symposium on Cerebral Blood Flow and Metabolism, Brain and Brain PET 2009, Chicago, Il. Plenary Speaker. June 29-July 3, 2009.

Invited Seminars at Universities: 1) University of Pennsylvania, Dept. of Biochemistry and Biophysics, May, 1985.

2) Johns Hopkins University, Anesthesiology Division, Dept. of Medicine, June, 1985.

3) Harvard Medical School, Massachusetts General Hospital, Dept. of Radiology, June,

1985.

4) Carnegie Mellon University, Dept. of Biological Sciences, Oct. 1985.

5) University of California at San Francisco, Dept. of Medicine, Nov. 1985.

6) Wright State University, Dept. of Biological Chemistry, Nov. 1985.

7) University of Alabama at Birmingham, Dept. of Medicine, January, 1986.

8) University of Pittsburgh, Dept. of Microbiology, Biochemistry and Molecular Biology. Pittsburgh, PA., Oct. 1987.

9) University of Massachusetts Medical Center, Dept. of Physiology, Worcester, MA., June

1989.

10) Academica Sinica, Institute of Molecular Biology, Taipei, Taiwan, Feb. 1990.

11) Allegheny Singer Research Institute. Pittsburgh, PA. April, 1990.

12) University of Pittsburgh, Cardiology Division, Dept. of Medicine. Pittsburgh, PA. May 1990.

13) University of Pennsylvania, Dept. of Biochemistry and Biophysics. Philadelphia, PA. May,1990.

14) Fox Chase Cancer Research Institute. Philadelphia, PA. July, 1991.

15) Institute for Cell Biology, ETH-Hönggerberg, Zurich, Switzerland, July, 1991.

16) University of Illinois, Department of Physiology and Biophysics and Beckman Institute,

Champain-Urbana, Ill., Oct., 1991.

17) Wright State University, Department of Biochemistry, Dayton, Ohio, Nov, 1991.

18) University of Arizona, Dept. of Physiology, Tucson, AZ., Dec., 1991.

19) University of Virginia, Dept. of Physiology, Charlottesville, Va. March, 1992.

20) University of Alabama, Dept. of Physiology and Biophysics, Birmingham, AL. May, 1992.

21) University of Pittsburgh, Dept. of Medicine, Cardiology Research Conference, Pittsburgh, PA. May 1992.

22) Centre College, Department of Biological Sciences, Danville, KY, Nov., 1992

23) Loyola University, Department of Molecular and Cellular Biochemistry, Chicago, IL. April,

1993.

24) National Institutes of Health, Heart, Lung, and Blood Institute, Laboratory of Cardiac Energetics, Bethesda, MD. Oct., 1993

25) Michigan State University, Department of Physiology, East Lansing, MI. Nov., 1993

26) University of Pittsburgh, Clinical Pharmacology Center, Pittsburgh, PA Jan , 1994

27) Massachusetts Institute of Technology, Health, Science, and Technology Program,

Cambridge, MA, May, 1994.

28) Beth Israel Hospital, Department of Radiology, Boston, MA. April, 1995.

29) University of Rochester, Department of Biophysics, May, 1995.

30) Massachusetts General Hospital, Department of Radiation Oncology, Boston, MA. May, 1995.

31) Massachusetts General Hospital, Stroke Group, Boston, MA. May, 1995.

32) University of Chicago, Department of Radiology, Chicago, IL. Oct., 1995.

33) University of Oregon, Institute of Neurosciences, Eugene, Or. May, 1996.

34) University of Pennsylvania, Dept. of Biochemistry and Biophysics. Philadelphia, PA.

Oct, 1996.

35) University of Washington, Departments of Physiology and Biophysics and Radiology, Seattle, WA. Feb. 1997.

36) Albert Einstein College of Medicine, Department of Physiology and Biophysics, N.Y.,

N.Y. March, 1997.

37) Massachusetts Institute of Technology, Health, Science, and Technology Program, Cambridge, MA, May, 1997.

38) University of Utrecht, Radiology Department, Utrecht, Netherlands, Sept., 1997.

39) Northwestern University Medical School, Feinberg Cardiovascular Research Institute, Jan.

22, 1998.

40) National Institute of Neurological Diseases and Stroke, NIH, Bethesda, MD. March, 1998.

41) Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA, March, 1999.

42) Brookhaven National Laboratories, Department of Chemistry, Brookhaven, NY, May 24, 2000.

43) Duke University, Department of Radiology, Durham, NC, Oct., 2000

44) Medical College of Wisconsin, Biophysics Research Institute, Dec. 2000.

45) Baylor College of Medicine, Department of Genetics, Houston, TX April, 2001.

46) Yale University, Department of Radiology, New Haven, CO, May, 2001

47) University of Massachusetts Medical School, Center for Comparative NeuroImaging

Opening Symposium, Sept. 2002, Keynote Speaker.

48) Robarts Research Institute, Imaging Research Laboratories, London, Canada, April, 2003.

49) Weill Medical College of Cornell University, Sackler Institute for Developmental Psychobiology, NY, NY, April 2003.

50) Oregon Health Sciences University, Advanced Imaging Center, Inaugural Seminar,

Portland, Oregon, Jan., 2004.

51) University of Oregon at Eugene, Lewis Center for NeuroImaging and Department of Psychology, Eugene, Orgeon, Jan., 2004.

52) University College, London, Wellcome-Trust Centre for Neuroimaging Techniques,

Workshop on “Smart MR and Optical Contrast Agents”, London, UK, July 10, 2004. 53) Glaxo-Smith Kline, Mouse Imaging Center of Excellence, Opening Symposium, King of

Prussia, PA, Oct. 4, 2004.

54) New York University, Skirball Institute for Biomolecular Medicine, NY, NY Feb. 4. 2005.

55) Massachusetts General Hospital, A.A. Martinos Center for Biomedical Imaging, Charlestown, MA., March 23, 2005.

56) 10th Year Anniversary Symposium for University of Pittsburgh, MR Research Center, Keynote Speaker, Department of Radiology, University of Pittsburgh, Pittsburgh, PA, Feb. 22, 2005.

57) Emory University, Yerkes Primate Center, Nov. 10, 2005.

58) Pfizer, Bioimaging Center, Grand Opening, Keynote Speaker, Ann Arbor, Michigan, Feb. 7, 2006.

59) University of Georgia, Complex Carbohydrate Research Center, Athens, GA, March 9, 2006.

60) Center for Imaging Neurodegenerative Diseases Inaugural Conference. Veterans Administration Hospital, UCSF, San Francisco, CA, May 13, 2006.

61) Northwestern University, Department of Neurobiology, Evanston, Ill, May 23, 2006. 62) Walter J. Rodgers Seminar, Department of Radiology, University of Virginia,

Charlottesville, Va, Feb 8-9, 2007.

63) Keynote Speaker at Opening of the New 11.7T MRI Laboratory, Max Planck Institut fur Neurologische Forschung, Koln, Germany, May 18, 2007.

64) Opening Symposium, Magnetsonanzzentrum, Max Planck Institute Fur Biologische Kybernetik, Tubingen, Germany July 12-13, 2007.

65) Medical College of Wisconsin, Annual Graduate Student Invited Speaker, Department of

Biophysics, Milwaukee, WI., Oct 26, 2007. 66) Ohio State University, Department of Physics, Colombus, Ohio, Nov. 6, 2007.

67) Howard Florey Institute, University of Melbourne, Nov 15, 2007. 68) 10th Anniversary Symposium, Department of Biomedical Engineering, Emory/Georgia

Tech, Atlanta, GA, March 8, 2008.

69) Yale Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University, New Haven, CN April 1, 2008.

70) Department of Biomedical Engineering, State University of New York at Stony Brook, Stony Brook, NY. Oct 21, 2008.

71) NIH-Brown Graduate Partnership Fifth year Anniversary Retreat, Woods Hole, MA March 25-26, 2009.

Professional Service: Editorial Boards

American Journal of Physiology: Cell Physiology 1990 - 1996. Magnetic Resonance in Medicine 1995 – 2000. Contrast Media and Molecular Imaging 2005-present.

Advisory Committees

NMR Planning and Advisory Committee, Institute of Biomedical Sciences, Academica Sinica, Taipei, Taiwan Republic of China, Fall 1989- 1994.

External Advisory Committee of the Regional Resource in Magnetic Resonance and Optical Spectroscopy, Dept. of Radiology, University of Pennsylvania. 1993-1998.

Scientific Advisory Committee, Functional Imaging Research Program, University of Pittsburgh Medical Center, Pittsburgh, PA. 1994-1999.

External Scientific Advisory Committee, Southwestern Small Animal Imaging Resource, University of Arizona, Tucson, Az. 2000-2004.

External Scientific Advisory Committee, Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA 2000-present.

National Advisory Committee for Mouse Metabolic Phenotyping Centers, NIDDK, NIH, 2001-2006.

External Scientific Advisory Committee, Washington University Small Animal Imaging Resource, Washington University, St. Louis, MO. 2002-present.

External Scientific Advisory Committee, Magnetic Resonance Research Center, University of Minnesota, Minneapolis, MN. 2004-present.

Selection Committee, 2004, J. Allyn Taylor International Prize in Medicine, Robarts Resarch Institute, London, Ontario, Canada.

Trustee, Society of Molecular Imaging, 2004-2006. Committee for "Revealing Chemistry through Advanced Chemical Imaging", Board

on Chemical Sciences and Technology, national Research Council, National Academy of Sciences, 2004-2006.

Scientific Advisory Board, Singapore Bioimaging Consortium (SBIC), Biomedical Research Council, Singapore. 2006-present.

Organizing Committees for Meetings and Workshops

Organized Symposium on Magnetic Resonance Microimaging, Annual Meeting of the Microscopy Society of America, Kansas City, MO, Aug. 1995.

Organizing Committee, International Society of Oxygen Transport to Tissue, Annual Meeting, Pittsburgh, PA, Aug. 1995.

Organized Symposium on Functional Magnetic Resonance Imaging: From Molecules to Humans, Annual Meeting of the Microscopy Society of America, Kansas, City , MO, Aug, 1996.

Organized Symposium on Biological Structure and Function using Magnetic Resonance: A Symposium in honor of Chien Ho. Pittsburgh, PA, Nov 13, 2004.

Scientific Program Committee, Annual Meeting of Society of Molecular Imaging, Cologne, Germany, Sept. 7-10, 2005.

Service to the International Society of Magnetic Resonance in Medicine Scientific Program Committee, Society of Magnetic Resonance in Medicine Annual

Meeting, Berlin, Germany, Aug. 1992. Education Committee, Society of Magnetic Resonance in Medicine, 1993. Workshop Committee, Society of Magnetic Resonance, 1994-1996. Young Investigator Awards Committee, International Society of Magnetic Resonance

in Medicine, 1996-1998. Executive Committee, Dynamic Spectroscopy Study Group, International Society of

Magnetic Resonance in Medicine, 1999. Nominations Committee, 2000. Co-Organized Educational Course on MR of Transgenic Mouse Models, International

Society of Magnetic Resonance in Medicine, 2003. Miscellaneous

NIH Reviewer: Numerous Ad-hoc to NIH Study Sections and NIH Site Visits. NSF Reviewer: Numerous proposals reviewed. Scientific Review Committee, Pennsylvania American Heart Association 1993-1994.

Service to Carnegie Mellon University:

Member of Biochemistry-Biophysics Program and Biomedical Engineering Program, Spring, 1987-1999.

Graduate Admissions Committee, Dept. of Biological Science, Spring, 1988 - 1993. Developmental Biology Faculty Search Committee, Dept. of Biological Sciences,

1988. Pittsburgh NMR Center for Biomedical Research, Scientific Advisory Committee,

1987-1999. Pittsburgh NMR Center for Biomedical Research, Technical Advisory Committee,

Fall, 1988-1999. Institutional Animal Care and Use Committee, Spring 1989-1999. NIH Training Grant Steering Committee, Dept. of Biological Sciences, Fall 1990 -

Spring 1993. Institutional Biosafety Committee, University of Pittsburgh/Carnegie Mellon

University Fall, 1990-1999. Committee to Review Department of Biological Sciences Head, Winter, 1992-1993 NMR Physicist Search Committee, Pittsburgh NMR Center for Biomedical

Research, Fall, 1990-spring, 1991. Task Force on Animal Facilities, Spring, 1990. Executive Committee Member, NSF Science and Technology Center for Light

Microscopy Imaging and Biotechnology, Spring 1990- Spring, 1994. Mellon College of Science Ad-Hoc Committee on Non-Tenured Appointments. Fall,

1992-Spring 1993. Mellon College of Science Search Committee for Associate Dean of Student Affairs. Winter, 1992-1993. Search Committee, Chief of Cardiology, Dept. of Medicine, Univ. of Pittsburgh,

Pittsburgh, PA. 1993 Department of Biological Sciences Strategic Planning Committee, Spring, 1994. Department of Biological Sciences Search Committee for Eberly Chair and junior

faculty in structural biology, 1994-1995.

Planning and Steering Committee Member, Center for the Neural Basis of Cognition, 1994-1999.

Health Professions Program Advisory Committee, 1995-1999. Carnegie Mellon University Committee on Non-tenured Appointments, Fall 1995-

1997 Search Committee for President of Carnegie Mellon University, 1996-1997 Search Committee for Neurobiologist, Department of Biological Sciences, Spring

1998. Initiated and Organized Annual Faculty-Student Softball Game at the Department of

Biological Sciences Annual Retreat, Fall, 1987- Fall, 1998. Service to National Institutes of Health

NIH In Vivo NMR Center Steering Committee, 1999-present.. Committee Member, Program for Faculty Development, NINDS, 1999. Planning Committee, Transgenic Mouse Facility, NINDS, 1999. Search Committee, Associate Director for Radiologic and Imaging Sciences, Clinical

Center, 1999. Search Committee, Neuroimaging Branch Chief, NIMH, 2000. Search Committee, MR Spectroscopy Tenure Track, NIMH, 2000 Speaker at NIH/Cornell Veterinary Student Leadership Program, NIH, June, 2000. Speaker at Mouse Interest Group, NIH, Oct. 3, 2000. Speaker at Lab. of Kidney and Electrolyte Metabolism, Laboratory Meeting, NHLBI,

NIH, Nov. 17, 2000. National Neuroscience Research Center Scientific Planning Committee, Dec. 2000-

2001. Participant in NIH Neuroscience Program for High School Teachers, “Mind over

Matter: Frontiers of Neuroscience, Feb. 27, 2001 Speaker at NCI retreat on “Mouse Models of Human Cancer”, Frederick, MD, Jan.,

2002. Speaker at NINDS Council 153rd Meeting, Feb. 14-15, 2002, Bethesda, MD. Speaker at “NIH Third Inter-Institute Workshop on Diagnostic Optical Imaging and

Spectroscopy: the Clinical Adventure”. Bethesda, MD, Sept 26-27,2002. Committee Member, NINDS Tenure Track Review Committee, 2002. Chair, Search Committee, Non-Human Primate fMRI Tenure Track, NIMH 2002. Member Search Committee, Molecular Imaging Tenure Track, Imaging Sciences

Program, CC, 2002. Committee Member NIMH Tenure and Promotions Committee, 2002-2004. Chair, Committee to evaluate NINDS Light Imaging Facility, 2003. Committee Member to evaluate NINDS Protein Sequencing Facility, 2004. Member Search Committee, Scientific Director, NINDS, NIH, 2004-2005. Scientific Director, NINDS, NIH, 2007- Many NIH committees, searches, etc.... Speaker at NCI Center for Cancer Research Tenure-Track Investigators Symposium

entitled,"From Molecular Mechanisms to Diagnostics and Treatment, May 11, 2007, Bethesda, MD.

Speaker at NCI Laboratory of Cancer Biology and Genetics Retreat, Nov 29, 2007, Rocky Gap Lodge Conference Center, Cumberland, MD.

Member Search Committee, Scientific Director NIMH, NIH, 2008.

Member Search Committee, Scientific Director NIDA, NIH, 2010. Honors/Awards:

Outstanding Teaching Assistant Award, Depart. of Chemistry, U of Ca, Berkeley, CA. 1979. Outstanding Student Research Award, West. Section, Am Fed Clin Res, Carmel, CA. 1984. Research Career Development Award. Heart, Lung and Blood Institute, NIH 1993-1998. Eberly Chair in Structural Biology and Chemistry, Carnegie Mellon University, 1997-1999. Senior Biomedical Research Service, National Institutes of Health, 1999- 2006. Gold Medal, International Society of Magnetic Resonance in Medicine, 2002. Allan and Maria Myers Fellow, Florey Neuorsciences Institute, University of Melbourne, and

Grass Fellow, Melbourne Neuroscience Chapter, Nov. 2007 Fellow of the International Society of Magnetic Resonance in Medicine, Elected 2010.

Bibliography: 1) Self Association of Unconjugated Bilirubin IX in Aqueous Solution at pH 10 and Physical-

Chemical Interactions with Bile Salt Monomers and Micelles. M.C. Carey and A.P. Koretsky, Biochem. J. 179, 675-689 (1979).

2) Feasibility of 31P NMR to Study Metabolic Effects of Renal Ischemia in vivo.

A.P. Koretsky, W. Strauss, V. Basus, J. Murphy, P. Bendel, T.L. James, and M.W. Weiner. In "Acute Renal Failure", ed. H.E. Eliahu, John Libbey (London) pp 42-46 (1982).

3) A Device for Maintaining Viable Cells at High Densities for NMR Studies. G.S. Karczmar,

A.P. Koretsky, M.J. Bissell, M.P. Klein and M.W. Weiner. J. Magn. Resonan. 53, 123-128 (1983).

4) An in vivo NMR Probe Circuit for Improved Sensitivity. J. Murphy-Boesch and

A.P. Koretsky. J. Magn. Resonan. 54, 526-532 (1983). Reprinted in "Key Papers in Physics: No. 2. NMR in Biomedicine: The Physical Basis". Edited by Eiichi Fukushima. American Institute of Physics (1989).

5) 31P NMR Spectroscopy of Rat Organs in situ Using Chronically Implanted Radiofrequency

Coils. A.P. Koretsky, S. Wang, J. Murphy-Boesch, M.P. Klein, T.L. James, and M.W. Weiner. Proc. Natl. Acad. Sci. USA 80, 7491-7495 (1983).

6) Comparison of 31P NMR spectra of in vivo Rat Brain using Convolution Difference and

Saturation with a Surface Coil. Source of the Broad Component in the Brain Spectrum. R. Gonzalez-Mendez, L. Litt, A.P. Koretsky, J. von Colditz, M.W. Weiner and T.L. James. J. Magn. Resonan. 57, 526-533 (1984).

7) 31P NMR Magnetization Transfer Measurement of Phosphorus Reactions. A.P. Koretsky

and M.W. Weiner. In "Biomedical Magnetic Resonance" eds. A. Margulis and T.L. James, Radiology Research and Education Foundation (San Francisco) pp 209-230 (1984).

8) Measurement of Renal Intracellular pH by 31P NMR: Relationship of pH to

Ammoniagenesis. W.R. Adam, A.P. Koretsky, and M.W. Weiner. Cont. Nephrol. 47, 15-21 (1985).

9) Use of Magnetization Transfer Techniques to Detect Exchange Involving Small Metabolite

Pools: Relevance to Subcellular Compartmentation of Creatine Kinase. A.P. Koretsky, V.J. Basus, T.L. James, M.P. Klein, and M.W. Weiner. Magn. Resonan. Med. 2, 586-594 (1985)

10) 31P NMR Saturation Transfer Measurements of Phosphorus Exchange Reactions in Rat

Heart and Kidney in situ. A.P. Koretsky, S. Wang, M.P. Klein, T.L. James, and M.W. Weiner. Biochemistry, 77-84 (1986).

11) Loading Characteristics of Surface Coils Constructed from Wire and Foil. R.S. Balaban,

A.P. Koretsky, and L.A. Katz. J. Magn. Resonan. 68, 556-560 (1986).

12) Renal Intracellular pH in Rats in vivo by 31P NMR: Relationship of pH to Ammoniagenesis. W.R. Adam, A.P. Koretsky, and M.W. Weiner. Am. J. Physiol. 251, F904-F910 (1986).

13) Measurement of Tissue Potassium in vivo Using 39K NMR. W.R. Adam, A.P. Koretsky, and

M.W. Weiner. Biophys. J. 51, 265-271 (1987). 14) Determination of Renal Molar Concentrations of Phosphorus Containing Metabolites in vivo

using 31P NMR. N.R. Shine, J.A. Xuan, A.P. Koretsky and M.W. Weiner. Mag. Resonan. Med., 4, 244-251 (1987).

15) Changes in Pyridine Nucleotide Levels Alter Oxygen Consumption and Extra-Mitochondrial

Phosphates in Isolated Mitochondria: a 31P NMR and NAD(P)H Fluorescence Study. A.P. Koretsky and R.S. Balaban. Biochim. Biophys. Acta 893, 398-408 (1987).

16) Determination of Pyridine Nucleotide Fluorescence from the Perfused Heart Using an

Internal Standard. A.P. Koretsky, L.A. Katz, and R.S. Balaban. Am. J. Physiol. 253, H856-H862 (1987).

17) Respiratory Control in the Glucose Perfused Heart: A 31P NMR and NADH Fluorescence

Study. L.A. Katz, A.P. Koretsky, and R.S. Balaban. FEBS Lett. 221, 270-276 (1987). 18) NMR Investigations of Cellular Energy Metabolism. R.S. Balaban, A.P. Koretsky, and

L.A. Katz. Annals N.Y. Acad. Sci. 508, 113-116 (1987). 19) Effects of Fatiguing Exercise on High Energy Phosphates, Force, and EMG: Evidence for

Three Phases of Recovery. R.G. Miller, D. Giannini, H.S. Milner-Brown, R.B. Layzer, A.P. Koretsky, D.Hooper, and M.W. Weiner. Muscle and Nerve 10, 810-821 (1987).

20) Potassium Adaptation: 39K NMR Evidence for Intracellular Compartmentalization of K+.

W.R. Adam, A.P. Koretsky, and M.W. Weiner. Am. J. Physiol. 254, F401-F408 (1988). 21) 31P NMR Studies on the Role of Pyruvate Dehydrogenase Activation in the Control of Heart

Respiration. L.A. Katz, A.P. Koretsky, and R.S. Balaban. Am. J. Physiol. 255, H185-H188, 1988.

22) The Mechanism of Respiratory Control in the in vivo Heart. A.P. Koretsky, L.A. Katz, and

R.S. Balaban . J. Mol. Cell. Cardiol. 21 (Supplement I), 59-66 (1989). 23) The B Isozyme of Creatine Kinase is Active as a Fusion Protein in E. coli: in vivo Detection

by 31P NMR. A.P. Koretsky and B.A. Traxler. FEBS Lett. 243, 8-12 (1989). 24) NMR Detection of Creatine Kinase Expressed in Liver of Transgenic Mice: Determination of

Free ADP Levels. A. P. Koretsky, M. J. Brosnan, L. Chen, J. Chen, and T. Van Dyke. Proc. Natl. Acad. Sci. (USA) 87, 3112-3116 (1990).

25) Measurement of Cerebral Blood Flow in Rat Brain by 19F NMR Detection of

Isofluoromethane Washout. J.A. Detre, C. J. Eskey, and A.P. Koretsky. Magn. Resonan. Med. 15, 45-57 (1990).

26) Absence of pH Changes During Altered Work in the In Vivo Sheep Heart: A 31P NMR

Investigation. J.A. Detre, A.P. Koretsky, D.S. Williams, and C. Ho. J. Mol. Cell. Cardiol. 22, 543-553 (1990).

27) Nuclear Magnetic Resonance Determination of Flow, Lactate, and Phosphate Metabolites

During Amphetamine Stimulation of the Rat Brain. J.A. Detre, D.S. Williams, and A.P. Koretsky. NMR in Biomed. 3, 272-278 (1990).

28) Free ADP Levels in Transgenic Mouse Liver Expressing Creatine Kinase: Effects of Enzyme

Activity, Phosphogen Type, and Substrate Concentration. M.J. Brosnan, L. Chen, T.A. Van Dyke and A.P. Koretsky. J. Biol. Chem. 265, 20849-20855 (1990).

29) Phosphocreatine Protects Hepatic ATP From a Fructose Load in Transgenic Mouse Liver

Expressing Creatine Kinase. M.J. Brosnan, L. Chen, C.E. Wheeler, T. A. Van Dyke, and A.P. Koretsky. Am. J. Physiol. 260, C1191-C1200 (1991).

30) Manipulating Creatine Kinase Activity in Transgenic Mice to Study Control of Energy

Metabolism. M.J. Brosnan, J.M. Halow, and A.P.Koretsky. Biochem. Soc. Trans. 19, 1010-1014 (1991)

31) Perfusion Imaging. J.A. Detre, D.S. Williams, J.S. Leigh, and A.P. Koretsky. Magn.

Resonan. Med. 23, 37-45 (1992). 32) Application of Localized In Vivo NMR to Whole Organ Physiology in the Animal. A.P.

Koretsky and D.S. Williams. Ann. Rev. Physiol. 54, 799-826 (1992). 33) Investigation of Cell Physiology in the Animal Using Transgenic Technology. A.P.

Koretsky. Am. J. Physiol. 262, 263-277 (1992). 34) Magnetic Resonance Imaging of Perfusion Using Spin Inversion of Arterial Water. D.S.

Williams, J.A. Detre, J.S. Leigh, and A.P. Koretsky. Proc. Natl. Acad. Sci. (USA). 89, 212-216 (1992).

35) Measurement of Brain Perfusion by Volume Localized NMR Spectroscopy using Inversion

of Arterial Water Spins: Accounting for Transit Time and Cross-Relaxation. W.G. Zhang, D.S. Williams, J.A. Detre, and A.P. Koretsky. Magn. Resonan. Med. 25, 362-371 (1992).

36) The Role of Magnesium in Post-Ischemic Cardiac Dysfunction. K.E. Sommers, A. Ohkado,

E. Simplaceanu, A.P. Koretsky, C. Ho, and P. del Nido. Surgery 112, 159-165 (1992). 37) Cultivator for NMR of Suspended Cell Cultures. A. J. Meehan, C. J. Eskey, A.P. Koretsky,

and M.M. Domach. Biotech. Bioeng. 40, 1359-1366 (1992). 38) 2H Imaging of Tumor Blood Flow: Spatial and Temporal Heterogeneity in a Tissue-Isolated

Mammary Adenocarcinoma. C.J. Eskey, A.P. Koretsky, M.M. Domach, and R.K. Jain. Cancer Res. 52, 6010-6019 (1992).

39) Altering Creatine Kinase Isoenzymes in Transgenic Mouse Muscle by Overexpression of the B Subunit. M. J. Brosnan, S.P. Raman, L. Chen, and A.P. Koretsky. Am. J. Physiol. 264, C151-C160 (1993).

40) Response of Normal and Re-perfused Livers to Glucagon Stimulation: NMR Detection of

Blood Flow and High Energy Phosphates. T.R. Walsh, J.A. Detre, A.P. Koretsky, E. Simplaceanu, J.M. Halow, P. Rao, L. Makowka, and C. Ho. Biochim. Biophys. Acta 1181, 7-14 (1993).

41) Role of Oxygen versus Glucose in Energy Metabolism in a Mammary Carcinoma Perfused

Ex Vivo: Direct Measurement by 31P NMR. C.J. Eskey, A.P. Koretsky, M.M. Domach, and R.K. Jain. Proc. Natl Acad. Sci. 90, 2646-2650 (1993).

42) Measurement of Rat Brain Perfusion by NMR using Spin Labeling of Arterial Water: in vivo

Determination of the Degree of Spin Labeling. W. Zhang, D.S. Williams, and A.P. Koretsky. Magn. Resonan. Med. 29, 416-421 (1993).

43) Fast Serial MRI of Perfusion in the Rat Brain using Spin Inversion of Arterial Water. D.S.

Williams, J.A. Detre, W. Zhang, and A.P. Koretsky. Bull. Magn. Resonan. 15, 60-63 (1993). 44) Magnetic Resonance Imaging of Perfusion in the Isolated Rat Heart using Spin Inversion of

Arterial Water. D.S. Williams, D.J. Grandis, W. Zhang, and A.P. Koretsky Magn. Resonan. Med. 30, 361-365 (1993) .

45) Phosphocreatine Protects Transgenic Mouse Liver Expressing Creatine Kinase from Hypoxia

and Ischemia. K. Miller, J. Halow, and A.P. Koretsky Am. J. Physiol. 265, C1544-C1551 (1993).

46) Perfusion Imaging of the Rat Kidney using MRI. D.S. Williams, W. Zhang, A.P. Koretsky,

and S. Adler. Radiology 190, 813-818 (1994). 47) Tissue Specific Perfusion Imaging using Arterial Spin Labeling. J.A. Detre, W. Zhang, D.A.

Roberts, A.C. Silva, D.S. Williams, D.J. Grandis, A.P. Koretsky, and J.S. Leigh. NMR in Biomedicine 7, 75-82 (1994). Figures from this Review were reprinted in text book entitled, "NMR and Its Applications to Living Systems" by D.G. Gadian. p 119. Oxford University Press, 1995.

48) Nuclear Magnetic Resonance Detection of the Consequences of Transgene Expression. A.P.

Koretsky. News in Physiological Sciences 9, 197-202 (1994). 49) Hepatic High Energy Phosphate Metabolism in Transgenic Livers Expressing Creatine

Kinase as Revealed by 31P NMR. A.P. Koretsky, K.R. Miller, and J.M. Halow. Adv. Mol. Cell Biol. 11, 233-235 (1995).

50) Multi-Slice MRI of Rat Brain Perfusion during Amphetamine Stimulation using Arterial

Spin Labeling. A.C. Silva, W. Zhang, D.S. Williams, and A.P. Koretsky. Magn. Resonan. Med. 33, 209-214 (1995).

51) NMR Measurement of Perfusion using Arterial Spin Labeling without Saturation of Macromolecular Spins. W. Zhang, A.C. Silva, D.S. Williams, and A. P. Koretsky. Magn. Resonan. Med. 33, 370-376 (1995).

52) Magnetic Resonance Imaging of Cerebral Blood Flow. A.P. Koretsky, A.C. Silva. D.S.

Williams, W. Zhang, and J.A. Detre in "Cerebrovascular Diseases" edited by M.A. Moskowitz and L.R. Caplan, Butterworth-Heinemann, Boston, MA pp 463-473 (1995).

53) Non-Invasive Magnetic Resonance Imaging of Perfusion Using Spin Labeling of Arterial

Water. J.A. Detre, D.S. Williams, W.G. Zhang, J.S. Leigh, D.A. Roberts, and A.P. Koretsky in "Diffusion and Perfusion: Magnetic Resonance Imaging" eds. D. Le Bihan and B. Rosen, Raven Press, N.Y., N.Y. pp 296-304 (1995).

54) Functional and Energetic Effects of the Inotropic Agents EMD 57033 and BAPTA on the

Isolated Rat Heart. D.J. Grandis, P.J. del Nido, and A.P. Koretsky. Am. J. Physiol. 269, C472-C479 (1995).

55) Insights Into Cellular Energy Metabolism from Transgenic Mice. A. P. Koretsky

Physiological Reviews 75, 667-688 (1995). 56) Radiofrequency Magnetic Field Gradients have Reduced Sensitivity to Susceptibility

Gradients. G.S. Karczmar, J. River, and A.P. Koretsky. J. Magnetic Resonance Imaging 13, 791-797 (1995).

57) In situ 31P Nuclear Magnetic Resonance for Observation of Polyphosphate and Catabolite

Responses of Chemostat-Cultivated saccharomyces cerevisiae after Alkalinization. C.D. Castro, A.J. Meehan, A.P. Koretsky, and M.M. Domach. Applied and Environmental Microbiology 61, 4448-4453 (1995).

58) The Effect of Increased Creatine Kinase Activity on Contractile Function and Metabolism in

Mouse Skeletal Muscle. B.B. Roman, R. A. Meyer, and A.P. Koretsky. Am. J. Physiol. 270, C1236-C1245 (1996).

59) Estimation of Water Extraction Fractions in the Rat Brain Using Magnetic Resonance

Imaging of Perfusion with Arterial Spin Labeling. A. C. Silva, W.G. Zhang, D.S. Williams, and A.P. Koretsky. Magn. Resonan. Med. 35, 58-68 (1997).

60) Expression of Functional Human Mitochondrial Creatine Kinase in Liver of Transgenic

Mice. K. Miller, K. Sharer, J. Suhan, and A.P. Koretsky Am. J. Physiol. 272, C1193-C1202 (1997).

61) Combined Myofibrillar and Mitochondrial Creatine Kinase Deficiency Impairs Mouse

Diaphragm Isotonic Function. J.F. Watchko, M.J. Daood, G.C. Sieck, J.J. LaBella, B.T. Ameredes, A.P. Koretsky, and B. Wieringa. (1997) J. App. Physiol. 82, 1416-1423.

62) Manganese Ion Enhances T1 Weighted MRI During Brain Activation: An Approach to

Direct Imaging of Brain Function. Y.J. Lin and A.P. Koretsky (1997) Magn. Resonan. Med.

38, 378-388. Dr. Lin was the 1997 ISMRM Young Investigator Rabi Award winner for this work.

63) Evidence for the Exchange of Arterial Spin Labeled Water with Tissue Water in Rat Brain

from Diffusion Sensitized Measurements of Perfusion. A. C. Silva, D.S. Williams, and A.P. Koretsky (1997) Magn. Resonan. Med. 38, 232-237.

64) Concurrent Measurement of Hemoglobin Saturation and Oxygen Tension Maps in Mouse

Brain using an AOTF Microscope. R. D. Shonat, E. S. Wachman, W-H Niu, A.P. Koretsky, and D. Farkas (1997) Biophysical J. 73, 1223-1231. A figure from this paper was used for the cover of this issue of Biophysical Journal.

65) Functional Equivalence of Creatine Kinase Isoforms in Mouse Skeletal Muscle. B.B. Roman,

B. Weiringa, and A. P. Koretsky. (1997) J. Biol. Chem. 272, 17790-17794. 66) Differential Effects of Creatine Kinase Isoenzymes and Substrates on Cell Growth in

Transgenic Mouse Models of Liver Regeneration N. Askenasy and A.P. Koretsky (1997) Am. J. Physiol. 273, C741-C746.

67) The role of creatine kinase in inhibition of mitochondrial permeability transition. E.

O'Gorman, G. Beutner, M. Dolder, A.P. Koretsky, D. Brdiczka, and T. Walliman (1997) FEBS Lett. 414, 253-257.

68) Dilated Cardiomyopathy in transgenic mice with cardiac-specific overexpression of tumor

necrosis factor-alpha. T. Kobuta, C.F. McTierman, C.S. Frye, S.E. Slawson, A.P. Koretsky, A.J. Demetris, and A.M. Feldman. (1997) Circ. Res. 81, 627-635.

69) Fluorescence Measurement of Calcium Transients in Perfused Rabbit Heart Using Rhod-2.

P.J. del Nido, P. Glynn, P. Buenaventura, G. Salama, and A. P. Koretsky. (1998) Am. J. Physiol. 274, H728-H741.

70) Near-simultaneous hemoglobin saturation and oxygen tension maps in the mouse cortex

during amphetamine stimulation. R.D. Shonat, E.S. Wachman W. Niu, A. P. Koretsky, D.L. Farkas. (1998) Adv. Exptl. Med. Biol. 454, 149-158

71) Absence of Myofibrillar Creatine Kinase and Diaphragm Isometric Function During

Repetitive Activation. J. LaBella, M. Dowd, A.P. Koretsky, B.B. Roman, G.C. Sieck, B. Wieringa and J.F. Watchko. (1998) J. App. Physiol. 84, 1166-1173.

72) Cardiac MRI of the Normal and Hypertrophied Mouse Heart. S.E. Slawson, B.B. Roman,

D.S. Williams, and A.P. Koretsky (1998) Magn. Resonan. Med. 39, 980-987, 1998. 73) In Vivo Neuronal Tract Tracing Using Manganese Enhanced Magnetic Resonance Imaging .

R.G. Pautler, A.C. Silva, and A.P. Koretsky. (1998) Magn. Resonan. Med. 40, 740-748. 74) Simultaneous Glutamate and Perfusion fMRI Responses to Regional Brain Stimulation. S.D.

Forman, A.C. Silva, N. Dedousis, E.L. Barbier, J.D. Fernstrom, and A.P. Koretsky (1998) J. Cerebral Blood Flow and Met. 18, 1064-1074.

75) Radial Echo-Planar Imaging (rEPI). A.C. Silva, E.L. Barbier, I.J. Lowe, and A.P. Koretsky.

(1998) J. Magn. Resonan. 135, 242-247. 76) Single T-Cells Detected by High Resolution MRI. S. Dodd, M. Williams, J. Suhan, D.

Williams, A.P. Koretsky, C. Ho. (1998) Biophysical J. 76, 103-109. 77) Creatine and Cyclocreatine Treatment of Human Xenografts Studied by 31P and 1H

MRS.C.A. Kristensen, N. Askenasy, R.K. Jain, and A.P. Koretsky. (1999) British Journal of Cancer Research 79, 278-285.

78) Comparison of the Effects of Org 30029, Dobutamine, and High Calcium on Function and

Metabolism in Rat Heart. D.J. Grandis, G.A. MacGowan, and A.P. Koretsky. J. Molecular and Cellular Cardiology. (1999) J. Mol. Cell Cardiol. 30, 2605-2612

79) Perfusion Analysis Using Dynamic Arterial Spin Labeling. E. Barbier, A. Silva, H. Kim, D.

Williams, and A. P. Koretsky. (1999) Magn. Resonan. Med. 41, 299-308. 80) NMR-Observed Phosphate Trafficking and Polyphosphate Dynamics in Wild-Type and

vph1-1 Mutant S. cerevisae in Response to Stresses. C.D. Castro, A.P. Koretsky, and M.M. Domach. (1999) Biotechnol. Prog. 15, 65-73.

81) Performance trade-offs in in situ chemostat NMR. C.D. Castro, A.P. Koretsky, and M.M.

Domach. (1999) Biotechnol. Prog. 15, 185-95.

82) Quantitative Measurement of Calcium Transients in Perfused Mouse Heart using Rhod-2 Fluorometry. C. Du, G.A. MacGowan, D.L. Farkas, and A.P. Koretsky. (1999) Proc. SPIE 3602, 214-220.

83) Imaging Transgenic Animals. T.F. Budinger, D.A. Benaron, and A.P. Koretsky. (1999)

Annu. Rev. Biomed. Eng. 1, 611-648. 84) Myofibrillar or Mitochondrial Creatine Kinase Deficiency Alone does not Impair Mouse

Diaphragm Isotonic Function. J.F. Watchko, M.F. Daood, B. Weiringa, and A.P. Koretsky (2000) J. Appl. Physiol. 88:973-980.

85) Inotropic and Energetic Effects of Altering the Force-Calcium Relationship: Mechanisms,

Experimental Results, and Potential Molecular Targets. G.A. MacGowan and A.P. Koretsky (2000) J. Cardiac Failure 6, 144-156.

86) Rhod-2 Based Measurements of Intracellular Calcium in the Perfused Mouse Heart. G.A.

MacGowan, C.W. Du, J. P. Suhan, A. P. Koretsky, and D.L. Farkas. (2000) J. Biomed, Optics 6, 23-30.

87) Calcium Measurement in the Perfused Mouse Heart: Quantitating Fluorescence and

Absorbamce of Rhod-2 by Application of Photon Migration Theory. C.W. Du, G.A. MacGowan, D. Farkas, and A.P. Koretsky (2001) Biophys. J. 80, 549-561.

88) Ischemic Dysfunction in Hearts from Transgenic Mice Expressing Mutant Troponin I Lacking Functional Protein Kinase C Phosphorylation Sites. G.A. MacGowan, C.W. Du, D.B. Cowan, F. X. McGowan, R. J. Solaro, A. P. Koretsky, and P. J. del Nido. (2001) Am. J. Physiol. 280, H835-H843.

89) Perfusion Imaging Using Dynamic Arterial Spin Labeling (DASL). Barbier, E.L., Silva,

A.C., Kim, S.G., Koretsky, A.P. Magn. Resonan. Med. (2001) 45, 1021-1029. 90) Calibration of the Calcium Dissociation Constant of Rhod-2 in the Perfused Mouse Heart

using Manganese Quenching. C.W.Du, G.A. MacGowan, D. L. Farkas, and A. P. Koretsky. (2001) Cell Calcium 29, 217-227.

91) Changes in the Mitochondrial Proteome from Normal and Creatine Kinase Deficient Mouse Hearts Using Difference Gel Electrophoresis (DIGE). F. Kernec, M. Unlu, W. Labeikovsky, J. Minden, and A.P. Koretsky (2001) Physiological Genomics 6, 117-128.

92) Manganese Enhanced MRI of the Mouse Heart During Changes in Inotropy. T.C.C. Hu, R.G.

Pautler, G.A. MacGowan, and A. P. Koretsky (2001) Magn Resonan. Med. 46, 884-890.

93) Identification of Mucosal Injury in the Murine Nasal Airways by Magnetic Resonance Imaging: Site Specific Lesions Induced by 3-Methylindole. A. J. Weithoff, J.R. Harkema, A.P. Koretsky, and W.E. Brown. (2001) Toxicol. Appl. Pharmacol . 175, 68-75.

94) High calcium and dobutamine positive inotropy in the perfused mouse heart: myofilament

calcium responsiveness, energetic economy, and effects of protein kinase C inhibition. BMC Physiol. (2001)1, 12-22.

95) Compensatory Changes in Ca2+ and Myocardial O2 Consumption in beta-tropomyosin

Transgenic Hearts. G. A. MacGowan, C. Du, D. F. Wieczorek, and A. P. Koretsky. (2001) Am. J. Physiol. 281, H2539-H2548.

96) Transgenic Livers Expressing Mitochondrial and Cytosolic Creatine Kinase: Mitochondrial

Creatine Kinase Modulates Free ADP Levels. N. Askenasy and A. P. Koretsky. (2001) Am. J. Physiol. 282: C338-C346.

97) Induction and Apoptotic Regression of Lung Adenocarcinomas by Regulation of a K-ras

transgene in the Presence and Absence of Tumor Suppressors. G. H. Fisher, S. L. Wellen, D. Klimstra, J. M. Lenczowski, J. A. Tichelaar, M. Lizak, J. A. Whitsett, A. P. Koretsky, and H. E. Varmus. (2001) Genes and Development 15, 3249-3262.

98) Open Gradient Coil Designs for Magnetic Resonance Imaging. S.J. Dodd, D.S. Williams, C.

Olsen, A.C. Silva, A.P. Koretsky, and C. Ho (2002) Rev Sci. Instru. 73, 2208-2210. 99) Alpha-Adrenergic Response and Myofilament Activity in Mouse Hearts Lacking PKC

Phosphorylation Sites on Cardiac TnI. D.E. Montgomery, B.M. Wolska, W. G. Pyle, B.B. Roman, J.C. Dowell, P.M. Buttrick, A.P. Koretsky, P. Del Nido, and R.J. Solaro. (2002) Am. J. Physiol. Heart Circ. Physiol. 282, H2397-H2405.

100) Tracing Odor Induced Activation in the Olfactory Bulbs of Mice Using Manganese Enhanced Magnetic Resonance Imaging. R.G. Pautler and A.P. Koretsky (2002) NeuroImage 16, 441-448.

101) A Model of Blood-Brain Barrier Permeability to Water: Accounting for Blood Inflow and

Longitudinal Relaxation Effects. E. L. Barbier, K.S. St. Lawrence, E. Grillon, A.P. Koretsky, and M DeCorps (2002) Magn Resonan. Med 47, 1100-1109.

102) Separation of calcium transients and motion artifact using frequency filtering of fluorescent

signals arising from the perfused mouse heart. C. Du, Y. Pan, G.A. MacGowan, A.P. Koretsky. (2002) Proc. SPIE 4623, 281-286.

103) Imaging Cortical Anatomy by High Resolution MR at 3.0T: Detection of the Stripe of

Gennari in Visual Area 17. E.L. Barbier, S. Marrett, A. Danek, A. Vortmeyer, P. van Gelderen, J. Duyn, P. Bandettini, J. Grafman, A.P. Koretsky. (2002) Magn Resonan. Med. 48, 735-738.

104) Functional Assessment of Tissues with Magnetic Resonance Imaging. A. P. Koretsky (2002)

Ann. N.Y. Acad. Sci. 961, 203-205. 105) Dynamic Activity-Induced Manganese Dependent Contrast Magnetic Resonance Imaging

(DAIM MRI). I. Aoki, C. Tanaka, T. Takegami, T. Ebisu, M. Umeda, M. Fukunaga, A.C. Silva, A.P. Koretsky, and S. Naruse. (2002) Magn. Resonan. Med. 48, 927-933.

106) Laminar Specificity of fMRI Onset Times During Somatosensory Stimulation in the Rat.

A.C. Silva and A. P. Koretsky (2002) Proc. Natl. Acad. Sci. 99, 15182-15187. 107) MRI Detection of Ferritin Overload and Associated Neuronal Pathology in Iron Regulatory

Protein-2 Knockout Mice. C. Grabill, A.C. Silva, S.S. Smith, A. P. Koretsky, and T.A. Rouault. (2003) Brian Res. 971, 95-106.

108) Detection of Inflammation Following Renal Ischemia by Magnetic Resonance Imaging. S-K.

Jo, X. Hu, H. Kobayashi, M. Lizak, T. Miyaji, A. Koretsky, and R. Star. (2003) Kidney International 64, 43-51.

109) Highly Efficient Endosomal Labeling of Progenitor and Stem Cells with Large Magnetic

Particles Allows Magnetic Resonance Imaging of Single Cells K.A. Hinds, J.M. Hill, E.M. Shapiro, M.O. Laukkanen, A.C. Silva, C.A. Combs, T.R. Varney, R. S. Balaban, A.P. Koretsky, C.E. Dunbar (2003) Blood 102, 867-872.

110) Decreasing Motion Artifacts in Calcium-Dependent Fluorescence Transients from the

Perfused Mouse Heart Using Frequency Filtering. C. Du, Y. Pan, G.A. McGowan, and A.P. Koretsky (2004) Cell Calcium 35, 141-153.

111) New Developments in MRI. A.P. Koretsky (2004) NeuroRx 1, 155-164.

112) In Vivo Detection of Neuroarchitecture in the Rodent Brain Using Manganese Enhanced MRI. I. Aoki, Y.J.L. Wu, A.C. Silva, R.M. Lynch, and A.P. Koretsky (2004) Neuroimage 22, 1046-1059.

113) Functional MRI of the Rodent Somatosensory Pathway using Multislice Echo Planar

Imaging. S. D. Keilholz, A.C. Silva, M. Raman, H. Merkle, and A.P. Koretsky (2004) Magn. Resonan. Med. 52, 89-99.

114) Troponin I Protein Kinase c Phosphorylation Sites and Ventricular Function. G. MacGowan,

C. Evans, T. C. Hu, D. Debrah, S. Mullet, H.H. Chen, C.F. McTiernan, A. F. Stewart, A. P. Koretsky, and S. G. Shroff (2004) Cardiovascular Res. 63, 245-255.

115) MRI Detection of Single Particles for Cellular Imaging. E. M. Shapiro, S. Strtic, K. Sharer,

J.M. Hill, C.E. Dunbar, and A.P. Koretsky (2004) Proc. Natl. Acad. Sci 101, 10901-10906. 116) Manganese Enhanced MRI. J. H. Lee and A.P. Koretsky (2004) Curr. Pharm. Biotechnol. 5,

529-537. 117) Manganese-Enhanced Magnetic Resonance Imaging (MEMRI). A.P. Koretsky and A.C.

Silva. Editorial for special issue of NMR in Biomedicine on Manganese Enhanced MRI. (2004) NMR Biomed. 17, 527-531.

118) Manganese-Enhanced Magnetic Resonance Imaging (MEMRI): Methodological and

Practical Considerations. A.C. Silva, J.H. Lee, I. Aoki, and A.P. Koretsky (2004) NMR Biomed. 17, 532-534.

119) MRI Detection of Regional Blood Flow Using Arterial Spin Labeling. A. P. Koretsky, S. L. Talagala, S. Keilholz, A.C. Silva in "Clinical Magnetic Resonance Neuroimaging: Diffusion, Perfusion, and Spectroscopy" ed. J. Gilliard, A. Waldman, and Peter Barker, Cambridge University Press, Oxford, UK pp 119-140 (2005).

120) Octameric Mitochondrial Creatine Kinase Induces and Stabilizes Contact Sites Between the

Inner and Outer Membranes. O. Speer, N. Back, T. Buerklen, D. Brdiczka, A.P. Koretsky, T. Walliman and O. Eriksson. Biochem J. (2005) 385, 445-450.

121) Temporal Dynamics of the BOLD fMRI Impulse Response. J.A. de Zwart, A.C. Silva, P.

Van Gelderen, P. Kellman, M. Fukunaga, R. Chu, A.P. Koretsky, J.A. Frank; and J.H. Duyn. (2005) Neuroimage 24, 667-677.

122) Sizing it Up: Cellular MRI Using Micron Sized Particles. E.K Shapiro, S. Skrtic, and A.P. Koretsky (2005) Magn Resonan Med 53, 329-338.

123) Manganese Enhanced MRI (MEMRI) of Mouse Brain after Systemic Administration of MnCl2: Dose Dependence and Temporal Evolution of T1 Contrast. J.H. Lee, A.C. Silva, H. Merkle, and A.P. Koretsky (2005) Magn Resonan Med. 53, 640-648.

124) Manganese Enhanced MRI of Normal and Ischemic Canine Heart. T.C. Hu, T.F. Christian, A.H. Aletras, J.L. Taylor, A. P. Koretsky, and A.A. Arai (2005) Magn Resonan Med. 54, 196-200.

125) Simultaneous Detection of Blood Volume, Oxygenation, and Intracellular Calcium Changes

during Cerebral Ischemia and Reperfusion In Vivo using Photospectrometry. C. Du, A. P. Koretsky, I. Izrailtyan and H. Benveniste (2005) J. Cerebral Blood Flow and Metabolism 25, 1078-1092.

126) Improved Stem Cell MR Detectability in Animal Models by Modification of the Inhalation Gas. U. Himmelreich, R. Weber, P. Ramos-Cabrer, S. Wegener, K. Kandal, E. M. Shapiro, A.P. Koretsky, M. Hoehn. (2005) Molecular Imaging 4, 104-109.

127) Technological Advances in MRI Measurement of Brain Perfusion. J.H. Duyn, P. van Gelderen, L. Talagala, A. P. Koretsky and J.A. de Zwart. (2005) J. Magn. Resonan. Imaging 22, 751-753.

128) Catheter Confocal Fluorescence Imaging and Functional Magnetic Resonance Imaging of Local and Systems Level Recovery in the Regenerating Rodent Sciatic Nerve. G. Pelled, S.J. Dodd, and A.P. Koretsky (2005) Neuroimage 30, 847-856.

129) In Vivo Detection of Single Cells by MRI. E. M. Shapiro, K. Sharer, S. Skrtic, and A. P. Koretsky (2006) Magn Resonan Med 55, 242-249. Dr. Shapiro was a Young Investigator Award Finalist at the 2005 International Society of Magnetic Resonance in Medicine meeting for this work.

130) BOLD and CBV weighted Functional MR Imaging of Rat Somatosensory System. S.D. Keilholz, A.C. Silva, M. Raman, H. Merkle, and A. P. Koresky (2006) Magn Resonan Med 55, 316-324.

131) Cell Labeling for Magnetic Resonance Imaging with the T1 Agent Manganese Chloride. I. Aoki, Y. Takahashi, K. H. Chuang, A.C. Silva, T. Igarashi, C. Tanaka, R. W. Childs, and A. P. Koresky (2006) NMR Biomed. 19, 50-59.

132) Improved Neuronal Tract Tracing using Manganese Enhanced MRI with Fast T1 Mapping. K. H. Chuang and A. P. Koretsky (2006) Magn Resonan Med. 55, 604-611.

133) Contrast-enhanced in vivo imaging of breast and prostate cancer cells by MRI. Rodriquez. O., Fricke, S., Chien, C., Dettin, L., Van Meter, J., Shapiro, E., dai, H.N., Casimiro, M., Ileva, L., Dagata, J., Johnson, M., Koretsky, A., and Albanese, C. (2006) Cell Cycle 5, 113-119.

134) High Resolution Mapping of Tumor Redox Status by Magnetic Resonance Imaging using Nitroxides as Redox-Sensitive Contrast Agents. Ken-ichiro Matsumoto, Atsuko Matsumoto, Fuminori Hyodo, Alan P. Koretsky, Anastasia L. Sowers, James B. Mitchell, and Murali C. Krishna (2006) Clinical Cancer Resarch 12, 2455-2462 .

135) Spatial Flow-Volume Dissociation of the Cerebral Microcirculatory Response to Mild Hypercapnia. E.B. Hutchinson, A. P. Koretsky , and A.C . Silva (2006) Neuroimage 32, 520-530.

136) Extensive Heterogeneity in White Matter Contrast in High Resolution T2*-weighted MRI of the Human Brain at 7.0T. T.Q. Li, P. van Gelderen, H. Merkle, L. Talagala, A.P. Koretsky, and J. Duyn (2006) Neuroimage 32, 1032-1040.

137) Magnetic Resonance Imaging of the Migration of New Neuronal Presursors Generated in the

Adult Rodent Brain. E.M. Shapiro, O. Gonzalez, J. M. Garcia-Verdugo, A. Alvarez-Buylla, and A.P. Koretsky (2006) Neuroimage 32, 1150-1157.

138) Magnetic Resonance Spectroscopic Imaging Based Noninvasive Evaluation of Liver Repopulation by Transplanted Hepatocytes. C.S. Landis, K. Yamanouchi, H. Zhou. S. Mohan, N. Roy-Chowdhury, D.A. Shafritz, A. P. Koretsky, J. Roy-Chowdhury, H. P. Hetherington, and C. Guha (2006) Hepatology, 44, 1250-1258.

139) Cocaine Increases the Intracellular Calcium Concentration in Brain Independently of its Cerebrovascular Effects. C. Du, N.D. Volkow, A.P. Koretsky, J.S. Fowler, and H. Benveniste. J. Neuroscience (2006) 26, 11522-11531.

140) Observation of Two Distinct spatial-temporal BOLD clusters During Sensory Stimulation in Rats. G. Goelman, G. Pelled, G., S. Dodd, and A.P. Koretsky, A.P. Neuroimage (2007) 34, 1230-1226.

141) Functional MRI Impulse Response for BOLD and CBV Contrast in Rat Somatosensory

Cortex. Silva, A.C., Koretsky, A.P., and Duyn, J.H. (2007) Magn Resonan Med 57, 1110-1118.

142) Functional MRI Detection of Bilateral Cortical reorganization in the Rodent Brain Following Complete Peripheral Nerve Dennervation. G. Pelled, K.H. Chuang, S.J. Dodd, and A.P. Koretsky (2007) Neuroimage 37, 262-273.

143) High-Field MRI of Brain Cortical Substructure Based on Signal Phase. J.H. Duyn, P. van Gelderen, T.Q. Li, J.A. deZwart, A. P. Koretsky, and M. Fukunaga. (2007) Proc. Natl. Acad. Sci. USA 104, 11796-11801. Article was featured in "In this Issue" section of Proc. Natl. Acad. Sci USA and a commentary about this article was written by Wald and Fischl (2007) Proc. Natl. Acad. Sci. USA 104, 11513-11514. Work was ranked 53 of 100 top science stories of 2007 by Discover Magazine (Jan. 2008 issue p. 51).

144) Antibody-Mediated Cell Labeling of Peripheral T Cells with Micron Sized Particles of Iron Oxide (MPIOs) Allows Single Cell Detection by MRI. E.M. Shapiro, L.N. Medford-Davis, T.M. Fahmy, C.E. Dunbar, and A.P.Koretsky. (2007) Contrast Media Mol. Imaging 2, 147-153.

145) Delivery of Fluorescence Probes Using Iron Oxide Particles as Carriers Enables In Vivo Labeling of Migrating Neural Precursors for MRI and Optical Imaging. J. P. Sumner, R.

Conroy, E.Shapiro, J. Moreland, and A.P. Koretsky. (2007) J Biomed. Optics 12, 5104-.

146) Assignment of Cortical Laminar Architecture Using Manganese-Enhanced MRI. A.C. Silva, J. H. Lee, C. W-H. Wu, I. Aoki, J. Tucciarone, G. Pelled, and A.P. Koretsky (2008) J. Neurosci Methods 167, 246-257.

147) The Dependence of BOLD fMRI and Somatosensory Evoked Potentials on Stimulation of the Rat Forepaw with Various Pulse Waveforms. A G. Goloshevsky, A. C. Silva, S. J. Dodd and A. P. Koretsky (2008) Brain Res. 1195, 67-76.

148) Micron Sized Iron Oxide Particles (MPIOs) for Cellular Imaging: More Bang for the Buck. E.M. Shapiro and A.P. Koretsky in "Nanoparticles in Biomedical Imaging, Emerging Technologies and Applications" eds J. Bulte and M. Modo in "Fundamental Biomedical Technologies Vol3" ed M. Ferrari, Springer, NY pp 141-162 (2008).

149) Functional Reactivity of Cerebral Capillaries. B. Stefanovic, E. Hutchinson, V. Yakovleva, V. Schram, J.T. Russell, L. Belluscio, A.P. Koretsky, and A.C. Silva (2008) J. Cereb. Blood Flow Metab. 28, 961-972.

150) Controlled aggregation of ferritin to modulate MRI relaxivity. K. M. Bennett, E. M. Shapiro, C. H. Sotak, and A. P. Koretsky (2008) Biophysical J. 95, 342-351.

151) Mapping resting-state functional connectivity using perfusion MRI. K-H Chuang, P. v.

Gelderen, J. Bodurka, V.N. Ikonomidou, A. P. Koretsky, J. H. Duyn, S. L. Talagala (2008) Neuroimage 40, 1595-1605.

152) Brain Redox Imaging Using Blood-Brain Barrier Permeable Nitroxide MRI Contrast Agent. F. Hyodo, K.H. Chuang, A.G. Goloshevsky, A. Sulima, G.L. Griffiths, J.B. Mitchell, A.P. Koretsky, M.C. Krishna (2008) J. Cereb. Blood Flow Metab. 28, 1165-1174.

153) Micro-engineered Local Field Control for High-Sensitivity Multispectral MRI. G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2008) Nature 453, 1058-1063. Article was featured in Nature News and Views in commentary entitled, "A colourful future for MRI" by Richard Bowtell Nature 453, 993-994 (2008). Many media stories resulting from publication and NIST/NIH press release (eg stories by Reuters, Science News, Technology Review, etc...). Picked by editors of Nature as one of top articles of 2008 (Nature 456, xii-xiii, 2008).

154) MRI of Neural Circuits. J. H. Duyn and A.P. Koretsky (2008) Nature Clinical Practice Cardiovascular Medicine 5, S71-78 (Invited contribution to supplement entitled "Cardiovascular Imaging for Clinicians").

155) Manganese cell Labeling of Murine Hepatocytes Using Manganese(III)-Transferrin. C. Sotak, K. Sharer, and A.P. Koretsky (2008) Contast Med. Mol. Imaging 3, 95-105.

156) Mapping Prefrontal Circuits in vivo with Manganese-Enhanced MRI in Monkeys. J.M . Simmons, Z.S. Saad, M.J. Lizak, M. Ortiz, A.P. Koretsky and B. J. Richmond. (2008) J.

Neurosci 28, 7637-7647.

157) Convertible Manganese Contrast for Molecular and Cellular MRI. E.M. Shapiro and A.P. Koretsky (2008) Magn Resonan Med. 60, 265-269.

158) Tracking the Effects of Crusher Gradients on Gradient-Echo Bold Signal in Space and Time During Rat Sensory Stimulation. G. Goelman, G. Pelled, S. Dodd, and A.P. Koretsky (2008) Magn. Resonan. Med. 60, 548-554.

159) MRI of the basement membrane using charged nanoparticles as contrast agents. K.M. Bennett, H. Zhou, J.P. Sumner, S.J. Dodd, N. Bouraoud, K. Doi, R.A. Star, and A.P. Koretsky (2008) Magn Resonan Med. 60, 564-574.

160) Controlled Transport of Magnetic Particles Using Soft Magnetic Patterns. R.S. Conroy, G. Zabow, J. Moreland, and A.P. Koretsky (2008) Applied Physics Lett. 93, 203901-1-3.

161) In vivo Labeling of Adult Neural Progenitors for MRI with Micron Sized Particles of Iron Oxide: Quantitation of Labeled Cell Phenotype J.P. Sumner, E.M. Shapiro, D. Maric, R. Conroy, and A.P. Koretsky (2009) Neuroimage 44, 671-678.

162) Layer Specific Tracing of Corticocortical and Thalamocortical Connectivity in the Rodent

Using Manganese Enhanced MRI. J. Tucciarone, K-H Chuang, S.J. Dodd, A. Silva, G. Pelled, and A.P. Koretsky (2009) Neuroimage 44, 923-931.

163) Manganese Enhanced MRI Reveals Functional Circuitry in Response to Odorant Stimuli. K.H. Chuang, J.H. Lee, A.C. Silva, L. Belluscio, and A.P. Koretsky. (2009) Neuroimage 44, 363-372.

164) B1 Homogenization in MRI by Multilayered Coupled Coils. S. Wang, J. Murphy-Boesch, H. Merkle, A.P. Koretsky, and J. Duyn (2009) IEEE Trans Med. Imaging 28, 551-554.

165) Accounting for Nonspecific Enhancement in Neuronal Tract Tracing Using Manganese Enhanced MRI. K.H. Chuang and A.P. Koretsky (2009) Magnetic Resonance Imaging 27, 594-600.

166) Design and fabrication of a Micromachined, Multi-Spectral Magnetic Resonance Imaging Agent. G. Zabow, , A.P Koretsky, and J. Moreland (2009) Journal of Micromechanics and Microengineering 19, 025020+10.

167) Noninvasive Imaging of the Functional Effects of anti-VEGF Therapy on Tumor Cell Extravasation and Regional Blood Volume in an Experimental Brain Metastasis Model. J.J. Yin, K. tracy, J. Munasinghe, E. Shapiro, A.P. Koretsky and K. Kelley. (2009) Clinical and Experimental Metastasis 26, 403-414.

168) Temporal Changes in the T1 and T2 Relaxation Rated (R1 and R2) in the Rat Brain are

Consistent with the Tissue-Clearance Rates of Elemental Manganese. K.H. Chuang, A.P. Koretsky, and C.H. Sotak (2009) Magn Resonan Med 61, 1528-1532.

169) Targeting Neural Precursors in the Adult Brain Rescues Injured Dopamine Neurons. A. Androutsellis-Theotokis, M. Rueger, D. Park, H. Mkhikian, E. Korb, S. Poser, S. Walbridge, J. Munasinghe, A. Koretsky, R. Lonser, and R. McKay (2009) Proc. Natl. Acad. Sci USA 106, 13570-13575.

170) Ipsilateral Cortical fMRI Responses Following Peripheral Nerve Damage in Rats Reflects Interneuron Mediated Inhibition. G. Pelled, D.A. Bergstrom, P.L. Tierney, R. Conroy, K.H. Chuang, D. Yu, D. Leopold, J.A. Walters and A.P. Koretsky, A.P. (2009) Proc. Natl. Acad. Sci USA 106, 14114-14119.

171) The fabrication of uniform cylindrical magnetic nanoshells and their use as spectrally tunable

MRI Contrast Agents. G. Zabow, S. Dodd, J. Moreland, and A.P. Koretsky (2009) Nanotechnology 20, 385301.

172) Differential effects of Anesthetics on Cocaine’s Pharmacokinetic and Pharmacodynamic

Effects in Brain. C. Du, M. Tully, N.D. volkow, W.K. Schiffer, M. Yu, Z. Luo, A.P. Kroetsky and H. Benveniste (2009) Eur. J. Neurosci. 30, 1565-1575.

173) Chartacterization of T2* Heterogeniety in Human Brain White Matter. T.Q. Li, B. Yao, P.

van Gelderen, H. Merkle, S. Dodd, L. Talagala, A.P. Koretsky, and J. Duyn (2009) Magn Resonan Med 2009, 1652-1657.

174) Lambda Exonuclease Digestion of CGG Trinulcoetide Repeats. R.S. Conroy, A.P.

Koretsky, and J. Moreland. (2010) Eur. J. Biophys 39, 337-343 .

175) In vivo Detection of Individual Glomeruli in the Rodent Olfactory Bulb Using Manganese Enhanced MRI. K-H Chuang, L. Belluscio, and A.P. Koretsky (2010) Neuroimage 49, 1350-1356.

176) 3D Mapping of Somatotopic Reorganization with Small Animal Functional MRI. X. Yu, S. Wang, D-Y Chen, S. Dodd, A. Goloshevsky, and A.P. Koretsky. (2010) Neuroimage 49, 1667-1676.

177) Arterial Spin Labeling Demonstrates that Focal Amygdalar Glutamatergic Agonist Infusion Leads to Rapid Diffuse Cerebral Activation. J.P. Munasinghe, M. Banerjee, M.T. Acosta, M. Banks, A. heffer, A.C. Silva, A.P. Koretsky, W.H. Theodore (2010) Acta Neurolo Scand. 121, 209-216.

178) Dissolution of MnO Nanocrystals for MRI-T1 Contrast Agents. Y.C. Lee, J. Tucciarone, A.P.

Koretsky, and K. Krishnan (2010) submitted.

179) In vivo visualization of Cortical Boundaries in the Rodent Brain using Manganese Enhanced MRI as a Cytoarchitectonic Marker. C. Wu, S. Dodd, and A.P. Koretsky (2010) Neuroimage submitted. .

Patents: 1) United States Patent No. 4,633,181. "Apparatus and method for increasing the sensitivity of a

nuclear magnetic resonance probe". Inventors: J. Murphy-Boesch and A.P. Koretsky. Awarded 12/30/86.

2) United States Patent No. 5,402,785. "Methods for measuring perfusion using magnetic

resonance imaging". Inventors: J.S. Leigh, J.A. Detre, D.S. Williams, and A.P. Koretsky. Awarded 4/14/95.

3) International and United States Patent Pending. “Protein Assignment by Combinatorial

Epitope Recognition”. Inventors: J. Minden, R. Ravi, B. V. Halldorsson and A. Koretsky.

4) Patent Pending. "Method for Determining Redox Status of a Tissue". J.B. Mitchell, M.K. Cherukuri, J.A. Cook, F. Hyodo, A.P. Koretsky, K.I. Matsumoto, S. Subramanian, and D.A. Wink. Filed August, 2006.

5) Patent Pending. "Transmitt Profile Control in MRI". Inventors: A.P. Koretsky, J.H. Duyn, S. Wang, and H. Merkle. Provisional application filed 2007.

6) Patent Pending "Magnetic Microstructures for Magnetic Resonance Imaging (MRI) Systems" Inventors: G. Zabow, S. Dodd, A. Koretsky and J. Moreland. Provisional application filed 2008.