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Rafsos
Grb2
PTB
Ras
MAPK
Ubiquilin
Mint - 2 Mint - 3Mint - 1
Fe65
AICD
C
PS1 / PS2
Pen-2Aph - 1α1Aph - 1α2Aph - 1β
cleavageactivatesγ - secretase
γ - secretase
α - secretase
β - secretase
ADAM10ADAM17
BACE1
BACE2
- 38- 40- 42- 49
CLAC-P
Protease α2M
Aβ
Aβ Aβ
AβAβ
Aβ
Protease IDE
Protease NEP
Protease PLG
N
APP
NCT
OLIGOMERIZATION DEGRADATIONCLEARANCE / EXPORT
CYTOPLASM
Aβ
P3ApoE
ApoE ApoJ
SH2
Shc
Aβ
Aβ
Aβ
Aβ Aβ Aβ
Aβ
Aβ
YENPTY
LRP
NOTCH
ErbB4
CD44
P75N
T
R
γ secretase
E-CADHERIN
Alzheimer’s Disease: Amyloid Precursor Protein (APP) processing
www.abcam.comCopyright © 2010 Abcam, All Rights Reserved.
Alzheimers Card01:Layout 15/10/2010 09:31 Page 1
Related antibodies and proteins from Abcam: See more products at: www.abcam.com
162-10/10-PW
Antibodies Clonality Applications Host Species DatasheetReactivity www.abcam.com/ab… Featured antibodies
APH1a antibody (ab12104)
Clonality Applications Host Species cross reactivity
P IHC-FoFr, WB Rb Hu, Ms, Rat
beta Amyloid 1-42 antibody (ab10148)
Clonality Applications Host Species cross reactivity
P IHC-Fr, IHC-P, WB Rb Hu, Ms, Rat, Dog
Insulin degrading enzyme / IDE antibody (ab32216)
Clonality Applications Host Species cross reactivity
P IHC-FoFr, IHC-P, WB Rb Hu, Ms, Rat
p75 NGF Receptor antibody [ME20.4] (ab8877)
Clonality Applications Host Species cross reactivityM EM, Flow Cyt, ICC/IF, IHC-Fr, Ms Hu, Ms, Rat, Cat, Dog,
IHC-P, IP, RIA Pig, Rb, Shp
Raf1 (phospho S239) antibody (ab1095)
Clonality Applications Host Species cross reactivityP ICC/IF Rb Hu
Proteins/Peptides Applications Species Datasheetwww.abcam.com/ab…
ADAM10 antibody [mAbcam 73402] M WB Ms Hu 73402ADAM17 antibody P WB Rb Hu 77820alpha 2 Macroglobulin antibody P ICC/IF, WB Rb Hu 84176Amyloid beta precursor protein antibody [Y188] M Flow Cyt, ICC, IHC-FoFr, IHC-FrFl, IHC-P, IP, WB Rb Hu, Ms, Rat 32136Amyloid Precursor Protein (phospho Y757) antibody P IHC-FoFr, WB Rb Ms 19850APBA1 antibody P WB Rb Rat 3448Apolipoprotein E antibody P WB Rb Hu 85311BACE1 antibody P WB Rb Hu, Ms, Rat 63954BACE2 antibody P IHC-P, WB Rb Hu, Ms, Rat 8025beta Amyloid 1-40 antibody [BDI350] M ELISA, ICC, IHC-P, WB Ms Hu 20068beta Amyloid 17-42 antibody P ELISA Rb Hu 17327beta Amyloid antibody P ELISA, IHC-Fr, IHC-P Rb Hu, Ms 2539CD44 antibody P IHC-P, WB Rb Hu, Ms, Rat 41478CLACP antibody P IHC-P, WB Rb Hu, Ms 72529E Cadherin antibody P ICC/IF, WB Rb Hu 77287ErbB 4 (phospho Y1284) antibody P ELISA, ICC/IF, WB Rb Hu, Ms, Rat 61059FE65 antibody [EPR3538] M ICC, IHC-P, WB Rb Hu 91650GRB2 antibody P WB Rb Hu 79876Low Density LRP antibody [5A6] M ELISA, Flow Cyt, ICC/IF, IHC-Fr, IHC-P, WB Ms Hu, Ms, Rb 28320MEK1 antibody P ICC/IF, WB Rb Hu, Ms, Rat 42647Mint3 antibody P ICC/IF, WB Rb Ms, Rat 3450Neprilysin-like Protease beta antibody P ELISA, WB Rb Hu, Ms, Rat 81688Nicastrin antibody P WB Rb Hu, Ms, Rat 3444Notch1 antibody P IHC-P, WB Rb Hu 65297PEN2 antibody P WB Rb Hu, Ms 18189Plasminogen antibody P Conjugation, ELISA, IP, sELISA, WB Gt Hu, Rat 6189Presenilin 1 + 2 antibody P ELISA, WB Rb Hu 60120PTBP1 antibody [SH54] M ICC/IF, IHC-P, WB Ms Hu 30317Ras antibody [EP1125Y] M Flow Cyt, IP, WB Rb Hu, Ms, Rat 52939SHC antibody P ELISA, WB Rb Hu, Ms, Rat, Rb 24787Ubiquilin antibody P ICC/IF, WB Rb Hu, Ms, Hm 3341
ADAM10 protein (His tag) WB Hu 83118ADAM17 peptide (Activation site) ELISA, WB Hu 41215Amyloid beta precursor protein protein Inhib Hu 79731Amyloid Precursor Protein peptide BL Hu 7875APBA1 peptide BL Rat 4980APH1a peptide BL Hu 12394Apolipoprotein E protein SDS-PAGE Hu 91027BACE peptide BL Hu 7883BACE1 protein (Active) FuncS, SDS-PAGE Hu 73428BACE2 peptide BL Hu 8392BACE2 peptide BL Hu 5873beta Amyloid 1-42 protein (Tagged) SDS-PAGE Hu 82795CD44 peptide BL Hu 41477
Alzheimers Card01:Layout 15/10/2010 09:31 Page 2