Anatomy I - Unit 3:Basic Biochemistry

What is Biochemistry?

• Biochemistry is the study of the chemical interactions of living things.

• Biochemists study the structures and physical properties of biological molecules.– Often are involved in the manufacture of new

drugs and medical treatments

Elements in Living Organisms

• The most common elements found in living organisms include:

–Carbon (C)–Oxygen (O)–Nitrogen (N)–Hydrogen (H)–Phosphorus (P)–Sulfur (S)

Periodic Table of the Elements (excerpt)

Biochemistry: where chemistry and biology meet head-on

• Living things require millions of chemical reactions within the body, just to survive.

• Metabolism = all the chemical reactions occurring in the body.

• Organic molecules: – usually associated with living things. – always contain CARBON.– are “large” molecules, with many atoms– always have covalent bonds (share electrons)

Macromolecules of Cells

• Macro = large

• 4 types of macromolecules in cellular biology

1. Carbohydrates

2. Lipids

3. Proteins

4. Nucleic Acids

Macromolecule #1: Carbohydrates

• Sugars and groups of sugars

• Purposes: energy and structure

• Includes three types:– Monosaccharide (1 sugar – quick energy)– Disaccharide (2 sugars – short storage)– Polysaccharide (many sugars – energy

long storage & form structures)

Macromolecule #1: Carbohydrates

• Polysaccharide Examples:

– Glycogen—glucose polymer stored for future energy needs. Found in liver, muscle and sperm, etc.

– Cellulose—glucose polymer used to form fibers for plant structures. Humans can’t digest (fiber). Most abundant organic molecule.

– Chitin—glucose polymer for exoskeletons of some crustaceans & insects.

Polysaccharides

Polysaccharides

Macromolecule #2: Lipids

• Insoluble in water (think oil & water)

4 types: – 1-triglycerides (fats & oils)

• (long-term energy storage, insulation)

– 2-phospholipids (primary component of cell membrane)

– 3-steroids (cell signaling)• cholesterol molecules modified to form sex hormones.

(e.g. testosterone, estrogen, etc.)

– 4-waxes (protection, prevents water loss)• Used mainly by plants, but also bees, some furry

animals and humans.

Triglycerides

Phospholipids

Steroids

Waxes

Macromolecule #3: Proteins

• Probably the most complicated of all biological molecules.

• Serve the most varied purposes, including:

Support structural proteins (e.g., keratin, collagen)

Enzymes speed up chemical reactions

Transport cell membranes channels, transporters in blood

(e.g., Hemoglobin)

Defense antibodies of the immune system

Hormones cell signaling (e.g., insulin)

Motion contractile proteins (e.g., actin, myosin)

CollagenCollagen

Antibodies

Cellular Transport

actin & actin & myosin fibers myosin fibers

in musclesin muscles

Motion

Macromolecule #3: Proteins

• The building blocks of proteins are AMINO ACIDS. There are only 20 types of Amino Acids.

• There are millions of different proteins, and they are all built from different combinations of the 20 amino acids.

• Amino acids join together to form peptides, polypeptides, and polypeptide chains.

Macromolecule #4: Nucleic Acids

• Nucleotides: building blocks of nucleic acids.– Each nucleotide contains

• (a) phosphate molecule, • (b) nitrogenous base, and • (c) 5-carbon sugar

• Several types of nucleic acids, including:– DNA: deoxyribonucleic acid

• Genetic material, double stranded helix– RNA: ribonucleic acid

• Genetic material, single stranded– ATP: adenosine triphosphate

• High energy compound

DNADNA

Nucleotide Structure

THE BIG PICTURETHE BIG PICTURE

Chemistry is essential for Chemistry is essential for life…life…