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Summer/September 2017 Vol. XCVI, No.1
NORTHEASTERN SECTION • AMERICAN CHEMIC
ALSO
CIET
Y
FOUNDED 1898
NESACS
Monthly MeetingA Medicinal Chemistry Symposium at Takeda Oncologyon “Enabling Technologies: Atom to Antibody”
2017 ACS FellowsNamed
Andrew H. WeinbergSymposiumA Report from the 20th Annual Symposium
NESACS ElectionResults
2 The Nucleus Summer/September 2017
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The Nucleus Summer/September 2017 3
The Nucleus is published monthly, except June and August, by the Northeastern Section of the AmericanChemical Society, Inc. Forms close for advertising on the 1st of the month of the preceding issue. Textmust be received by the editor six weeks before the date of issue.Editor: Michael P. Filosa, Ph.D., 18 Tamarack Road, Medfield, MA 02052 Email:
[email protected]; Tel: 508-843-9070Associate Editors: Myron S. Simon, 60 Seminary Ave. apt 272, Auburndale, MA 02466
Morton Z. Hoffman, 23 Williams Rd., Norton, MA 02766Board of Publications: James Phillips (Chair), Mary Mahaney, Ajay Purohit, Ken DrewBusiness Manager: Joshua Fine, Email: [email protected] Manager: Vacant: contact Michael Filosa at [email protected] Coordinator: Xavier Herault, Email: [email protected]: Morton Hoffman and James PhillipsProofreaders: Donald O. Rickter, Morton Z. HoffmanWebmaster: Roy Hagen, Email: [email protected] 2017, Northeastern Section of the American Chemical Society, Inc.
The Northeastern Section of the American-Chemical Society, Inc.Office: Anna Singer, 12 Corcoran Road,Burlington, MA 01803(Voice or FAX) 781-272-1966.e-mail: [email protected] Homepage:http://www.NESACS.orgOfficers 2017ChairLeland L. Johnson, Jr.WuXi AppTecBrookline, [email protected] Levine35 Cottage StSharon, MA 02067-2130(516)[email protected] Past ChairJerry P. JasinskiKeene State CollegeKeene, NH [email protected] SingerMilliporeSigma3 Strathmore Rd, Natick, MA 01760774-290-1391, [email protected] Saha67 Bow StArlington, MA 02474-2744(978)[email protected] GordonArchivistKen MattesTrusteesRuth Tanner, Peter C. Meltzer, Dorothy PhillipsDirectors-at-LargeRalph Scannell, John Burke, David Harris,Ioannis Papayannopoulos, Michael P. Filosa,John NeumeyerCouncilors/Alternate CouncilorsTerm Ends 12/31/2017Michael P. Filosa John PodobinskiDoris I. Lewis Sonja Strah-PleynetPatricia A. Mabrouk Anna Waclawa SromekMark Tebbe Mary BurgessMorton Z. Hoffman Ralph ScannellTerm Ends 12/31/2018Katherine Lee Mukund S. ChorghadeCatherine E. Costello Andrew ScholteRuth Tanner R. Christian MoretonJackie O’Neil Ajay PurohitKenneth Mattes Robert LichterTerm Ends 12/31/2019Thomas R. Gilbert Leland L. Johnson, Jr.Mary Jane Shultz Mary A. MahaneyMichael Singer Jerry P. JasinskiLisa Marcaurelle Sofia SantosMarietta Schwartz Patrick M. Gordon
Contents2017 NESACS ACS Fellows Named_________________________4Rick Danheiser, Arthur Greenberg, Katherine Lee and Irvin LevyMonthly Meeting _______________________________________5A Medicinal Chemistry Symposium at Takeda Oncology“Enabling Technologies: Atom to Antibody”NESACS Election Results ________________________________5Announcements ________________________________________6Grants-in-Aid to Undergraduates to attend the 255th ACS National Meeting,March 18-22, 2018, New Orleans, LANESACS and the 2017 ACS AwardsChemists Celebrate Earth Day at the Museum of Science_______7by Jayashree Ranga, Salem State University and David Sittenfeld, Boston Museum of ScienceApproved Oncologic Drugs for Pediatric Use 2015-2017 _______8By James S. Weinberg, Biophysics Assay Laboratory20th Annual Andrew H. Weinberg Symposium ________________9By Steven Dubois, MD, Dana-Farber/Boston Children's Cancer and Blood Dis-orders CenterEducation Night Awards ________________________________10Photos by Morton Z. Hoffman19th Annual NSCRC ____________________________________11By Sofia Santos, Photos by Brian D'AmicoHistorical Note _______________________________________11Jean-Pierre Anselme 1936–2017Esselen Award Photos by Joel Laino_______________________13Calendar ____________________________________________16Cover: From the Esselen Award Meeting: (L-R) Dr. Karl Hansen, Mr. LelandJohnson, Dr. Neil Donahue, Dr. James Anderson and Mr. Gustavus John EsselenIV just after Mr. Esselen presented Dr. Donahue with the 2017 Gustavus JohnEsselen Award for Chemistry in the Public Interest. Photo by Joel Laino.Editorial Deadlines: October 2017 Issue: August 22, 2017 November 2017 Issue: September 22, 2017
All Chairs of standingCommittees, the editor of THE NUCLEUS, and the Trustees of SectionFunds are members of theBoard of Directors. AnyCoun cilor of the American Chemical Societyresiding within the section area is an ex officiomember of the Board of Directors.
4 The Nucleus Summer/September 2017
Rick Danheiser Massachusetts Insti-tute of Technology
Contributionto the science/pro-fession: Developednumerous innova-tive and elegantmethodologies, in-cluding the Danheiser Annulation, theDanheiser Benzannulation, and cycload-ditions of highly unsaturated conjugatedmolecules for the synthesis of complexcarbocyclic and heterocyclic organiccompounds.
Contribution to the ACS commu-nity: Through for his sustained tenureas Editor-in-Chief of Organic Syntheses,he championed reproducible, independ-ently validated, and practical proceduresfor useful synthetic transformations. Ad-vocated compellingly for increased re-producibility in chemical research.Arthur GreenbergUniversity of NewHampshire
Contributionto the science/pro-fession:Recognizedfor service as jour-nal founder/editorand college adminis-trator and for contributions to the fieldsof polycyclic aromatics, focusing onanalysis, hazards and metabolism, andstructural chemistry, especially strainedmolecules and amides.
Contribution to the ACS commu-nity: Recognized as an author of bookson the history and image of chemistry.Other contributions include public pre-sentations, volunteer service on profes-sional committees and boards, andeducator and Project SEED mentor.
Katherine LeePfizer, Inc.
Contributionto the science/pro-fession: As an out-standing medicinalchemist, she has dis-covered four com-pounds that havereached Phase II clinical trials. At Pfizer,she led the chemistry team that discov-ered a first-in-class IRAK4 inhibitor.
Contribution to the ACS commu-nity:A leader in the Northeastern LocalSection and the Division of OrganicChemistry, she introduced innovativeprograms to engage younger chemistsand help all chemists advance their ca-reers.Irvin Levy Gordon College
Contributionto the science/pro-fession: Honoredfor significant con-tributions in advanc-ing the field of greenchemistry educa-tion, including expanding the commu-nity of green chemists, contributingscientific communications, and increas-ing student engagement.
Contribution to the ACS commu-nity:Recognized for excellence in serv-ice to the Division of ChemicalEducation (CHED), bringing in new,cross-Divisional programming to theCHED program and introducing rele-vant, green chemistry programming tothe Division.They join the more than 1,050 ACS
members who have been named as Fel-lows since 2009 when the programbegan, including a total of 44 membersof NESACS.For a complete list of ACS Fellows, see<http://www.acs.org/content/dam/ac-sorg/funding/fellows/acs-fellows-list.xlsx> u
NESACS Sponsors 2016Platinum $5000+Amgen Biogen Johnson Matthey Millipore-SigmaPCI Synthesis SK Life Science
Gold $3500 up to $5000Navin Fluorine
Silver $2000 up to $3500Abbvie American Chemical Society IAC Grant Boston Foundation Esselen Bristol-Myers Squibb Mettler Toledo Novartis Strem Chemicals Vertex Pharmaceuticals
Bronze $500 up to $2000Alexion AstraZeneca Chemical Computing Group Cydan Development DeuteRx LLC GL Chemtech International Limited JEOL USA Inc Pharmacore Relay Therapeutics Selvita, Inc. Toxikon
2017 ACS Fellows NamedThe ACS has named 65 members as ACS Fellows in the Class of 2017, who werecelebrated at the National Meeting in Washington, DC, in August. Among themare four from NESACS:
For late breaking news, job postings and the latest meeting and event
information please visit us at
WWW.NESACS.ORG
THE COMMITTEE ONCHEMICAL ABSTRACTS(CCAS) WANTS YOUR
FEEDBACKVisit our page on ACS Network:
https://communities.acs.org/groups/chemical-abstracts-service-committee
or contact Michael Filosa with any suggestions at [email protected]
The Nucleus Summer/September 2017 5
Monthly MeetingThe 971st Meeting of the Northeastern Section of the AmericanChemical Society organized by the Medicinal Chemistry Section
A Medicinal Chemistry Symposium“Enabling Technologies: Atom to Antibody”
Thursday, September 14, 2017Takeda Oncology
40 Landsdowne Street, Cambridge, MA 02139For updated information please see the NESACS website. www.nesacs.org 5:00 pm NESACS Board Meeting (Room TBD)Symposium Schedule3:00 pm Refreshments3:15 pm Welcome: Raj Rajur, MedChem Program Chair, CreaGen, Woburn,
MA3:20 pm Introductory Remarks: (Moderator), Dan Elbaum, Retrophin Inc.,
Cambridge, MA Confirmed Speakers3:30 pm Ben Askew, Scifluor Lifesciences, Cambridge, MA4:15 pm Julie Liu, Concert Pharmaceuticals, Boston, MA5:00 pm Andrew Roughton, Encycle Therapeutics, Toronto, ON6:00 pm Social Hour6:45 pm Dinner7:30 pm Keynote Presentation
Introduction: Neal GreenSpeaker: Ravi Chari, Immunogen, Cambridge, MA“Antibody-Drug Conjugates (ADCs): A clinically validated con-cept in cancer therapy”
Organizing committee members: Raj Rajur, Chair, Mark Ashwell, Dan El-baum, Andrew Scholte, Jeremy Green, Blaise Lippa, Alan Rigby, Anne MaiWasserman, Neal Green, Mukund Chorghade.YOU MUST REGISTER IN ADVANCE TO ATTEND THE SYMPOSIUM:THERE IS NO REGISTRATION FEE. TO ATTEND THE SYMPOSIUM;DINNER RESERVATIONS ARE REQUIRED. PUBLIC IS INVITEDhttps://nesacs-september-2017-atom-to-antibody.eventbrite.com/Dinner reservations should be made no later than noon, Thursday, September 7,2017. Reservations are to be made using Eventbrite: Members, $30; Non-mem-bers, $35; Retirees, $20; Students, $10. Reservations for new members and foradditional information contact the Administrative Coordinator, Anna Singer, at(781) 272-1966 between 9am and 5pm or e-mail at [email protected]. Reser-vations not cancelled at least 24 hours in advance must be paid. Directions to Takeda: Use the following address for your GPS: 40 LandsdowneSt, Cambridge, MA 02139Visitor Parking: All visitors to Takeda Boston facilities in University Park maypark at the 55 Franklin Street Garage, located in the Star Market building; theFranklin Street Garage is a public parking garage and visitors will be chargedfor parking on an hourly basis.
Visitors parking is also available at the 30 Pilgrim or 80 Landsdowne Streetcontinued on page 14
NESACSElectionResults*Elected**Elected Alternate CouncilorChair
Andrew Scholte 175 *Raj (SB) Rajur 112
SecretaryMichael Singer 256 *
AuditorPatrick Gordon 223 *
TrusteeRuth Tanner 191 *Robert L. Lichter 73
Councilor/Alternate CouncilorMichael P. Filosa 213 *Carol Mulrooney 199 *Patricia A. Mabrouk 198 *Anna W. Sromek 193 *Sofia A. Santos 182 *Robert L. Lichter 177 **Morton Z. Hoffman 175 **Sonja Strah-Pleynet 171 **Andrew Scholte 166 **Patrick M. Gordon 159 **Matthew M. Jacobsen 153 Raj (SB) Rajur 148 Mukund S. Chorghade 104 June Lum 95 Raymond E. Borg 66 Ajay Purohit 49
Director at LargeJames U. Piper 144 *Ralph T. Scannell 126 *John M. Burke 121 Jens Breffke 103
Nominating CommitteeThomas R. Gilbert 195 *Caitlyn Mills 172 *Sonja Strah-Pleynet 134
Richards Award CommitteeDoris I. Lewis 186 *Jerry P. Jasinski 149 *Malika Jeffries-El 112 Ravi Sharma 57
Esselen Award CommitteeJohn E. Macor 178 *Prakash Rai 146 *Robert Hanson 102 Jeffrey I. Steinfeld 73 u
6 The Nucleus Summer/September 2017
Grants-in-Aid toUndergraduates to Attend the255th ACS National Meeting &Exposition, March 18-22, 2018,in New Orleans, LA The Northeastern Section of the Ameri-can Chemical Society (NESACS) willprovide Grants-in Aid of $350 to eachof four undergraduates to attend the255th ACS National Meeting in New Or-leans, LA, and to present a paper at theUndergraduate Research Poster Sessionin the Division of Chemical Education.The institutions of the successful appli-cants are expected to match the award. Eligibility: Applications will be ac-cepted from students at colleges anduniversities within the NortheasternSection of the ACS. The undergraduatestudent must be a chemistry, biochem-istry, chemical engineering, or molecu-lar biology major in good standing withat least junior status, and must be cur-rently engaged in undergraduate re-search.Application: Application forms may beobtained from the NESACS web site athttp://www.nesacs.org. The deadline forreceipt of completed applications byProfessor Matthew Gage, Chair of theGrants-in-Aid Committee, is October 2,2017. Completed applications are to besent to: Professor Matthew Gage, De-partment of Chemistry, University ofMassachusetts Lowell, 1 University Av-enue, Lowell, MA 01854 Phone:978/934-3683 Fax: 978/934-3013; e-mail: [email protected]: Applicants will be notifiedof the results by e-mail on October 9,2017. The deadline for electronic sub-mission of abstracts to the AmericanChemical Society in Washington, D.C.is October 16, 2017, 11:59 PM. u
NESACS and the 2017 ACSAwardsMembers of NESACS and former recip-ients of NESACS awards were recog-nized at the General Meeting of the ACSon Tuesday, April 4, 2017, during the253rd National Meeting in San Fran-cisco. Allison Campbell, ACS Presi-dent, presented the awards with theassistance of other distinguished ACSleaders.Kathryn C. Hach Award for Entre-preneurial Success sponsored by theKathryn C. Hach Award Fund to DavidR. Walt, Tufts University: “For invent-ing and commercializing microwell ar-rays that benefit research, Medicine,and agriculture with tremendous impacton the economy through job and valuecreation.” Laura Pence, ACS Board ofDirectors, assisted with the presentation.ACS Award in Surface Chemistrysponsored by the ACS Division of Col-loid and Surface Chemistry to CynthiaFriend, Harvard University: “For herparadigmatic developments in the mech-anistic understanding of oxygen-assisted
catalytic cycles on gold surfaces andtheir implementation to nanoporous goldcatalysts under realistic conditions.”Howard Fairbrother, ACS Division ofColloid and Surface Chemistry, assistedwith the presentation.In addition, the James Flack NorrisAward in Physical Organic Chem-istry sponsored by the ACS Northeast-ern Section was presented to Robert A.Moss, Rutgers University: “For poneer-ing research on carbenes, carbocations,diazirines, and reactive intermediates ingeneral, coupled with sustained peda-gogical contributions to physical or-ganic chemistry.” Leland Johnson, Jr.,NESACS Chair, assisted with the pres-entation.The recipient of the 2012 TheodoreWilliam Richards Medal for Conspicu-ous Achievement in Chemistry fromNESACS, Tobin J. Marks, Northwest-ern University, received the PriestleyMedal sponsored by the AmericanChemical Society: “For his dedicatedservice to the chemistry enterprise andpioneering research in catalytic poly-
Announcements
continued on page 14
Chemists Celebrate Earth Day (CCED)event, a STEM outreach event, was or-ganized at the Blue Wing of Museum ofScience, Boston on Sunday, April 23,2017 from 12 - 4 pm by the Northeast-ern Section of American Chemical So-ciety and Museum of Science (MoS).About 75 enthusiastic guest educatorsfrom 11 organizations engaged youngvisitors with ~15 hands-on activities re-lated to chemistry and this year’s theme“Chemistry Helps Feed the World”.About 500 visitors participated in thesefun-filled CCED activities at the event.Activities presented to visitors includedmaking dye, testing food for starch andsugar, chemistry of gum, chemistry ofmilk and soap, M&M E-factor, cabbagejuice indicator, gummy capsules, candychromatography, conductivity of vari-ous liquids, and making plastics out ofmushrooms.
Most of the guest educators wereeither undergraduates or high schoolstudents. The guest educators did anamazing job of engaging young audi-ence with food related hands-on scienceactivities. Special thanks to our guesteducators from Beyond Benign, GordonCollege, Malden High School, MaldenCatholic High School, MassachusettsMaritime Academy, Museum of Sci-ence, Northeastern University, NE-SACS, Salem State University,Simmons University, and Suffolk Uni-versity.
NESACS also participated in theCCED-2017 Illustrated Poem contest.The student received a $25 gift cardfrom amazon.com and the teacher re-ceived a $25 gift card from teacherwww.teachersource.com. Congratulations to the winners!Student: Ashmita Prajapati (3-5 Cate-gory), School or Sponsoring group: Gra-ham and ParkTeacher: Karen Engels
Thank you CCED guest educators!*Beyond Benign: Mollie Enright,Nephaelia Nichols, Loren Po, JoeRomeo, Mathew WinwardGordon College: Lian Atlas, QuincyDougherty, Victoria Ganss, Sara Lareau,Mirielle Nauman, Ivy Ngo, RachelOlugbemiMalden Catholic High School: JasonFeng, Harrt Han, Terri Li, William Liu,Diane Perito, Alex Qun, Sam Shen,Jianwei WangMalden High School: Martin Berry-man, Kawing Cheung, Vivian Du , AmyFong, Audrey Goon , Pete Jinapin, Wo-jciech Kochanczyk, Kaytlin Kwong,Hien Lau, Christina Luc, BrandonNguyen, Lynn Nguyen, Arsema Paulos,Joanna Tan, Tim Tso, Kelly Weng,Susan Wong, Meghan Yip, Tiffany Yu,Yu Wei Zeng, Yan Zheng, Wu Zheng,Tiffany Yu, Susan Wong
Massachusetts Maritime Academy:Ray LamMuseum of Science: Emily Hostetler,Meghan WrennNESACS: Cosmo Sabatino, HimanshuC ShahNortheastern University: BiruckAbreha, Courtney Bell, Jill Coghlan,Travis DeLano, Emma Langdon, Made-line MacDonnell, SunandhaaNarasimhan, Sanjana Phatak, CameronRederscheid Salem State University: EllenAcheampong, Prince Acheampong,Benjamin Bergstrom, Amanda Cesero,Chanmony Chap, Sunatib Choudhry,Sabrina Mohammed, Evelin Reyes, LilySanfilippo, Natasha Schmelte, VivianTam, Claudia Tangu, Jon WeaverSimmons College: Elaine BaulsirMancini, Luz Corrales, Chyenne YeagerSuffolk University: Allen Alfadhel, Ys-abella Batista, Janice Bautista, JulieBautista, Aziz Biyari, Kaitlyn Jenkins,Meri Kalashyan, Kubra Umit*I apologize if your name is not on thislist. NESACS will be organizing NationalChemistry Week (NCW) in October.The 2017 theme for NCW is “ChemistryRocks”: Exploring the chemistry ofrocks and minerals. u
The Nucleus Summer/September 2017 7
Chemists Celebrate Earth Day at theMuseum of Science: A Fun-filled STEM Outreach Event through NESACS & MoSby Dr. Jayashree Ranga, Salem State University and David Sittenfeld, Museum of Science
CCED guest educators at the MoS on April 23, 2017. Photo by Dr. Jayashree Ranga.
Ms. Ashmita Pra-japati with hercertificate fromNESACS CCED-2017 IllustratedPoem contest.Photo by Ms.Karen Engels.
8 The Nucleus Summer/September 2017
The good news - the FDA has approved 4 new drugs with in-dications for pediatric oncological use and added them to theoriginal list of 25 drugs published in October 2015 NESACSThe Nucleus. (See) http://www.nesacs.org/curr_events/other-sym/symp/weinberg_symp/andrew_weinberg_symp1995-2015.pdfRegulatory Approved Oncologic Drugs for Pediatric Use withPediatric Dosing 2015-2017
This brings the total in the last 64 years (since 1953) to 29drugs approved (about one every two years). In the last twoyears the rate has improved to two drugs a year. All four newdrugs are monoclonal antibodies: Dinutuximab is a mono-clonal antibody that targets glycolipid disialoganglioside(GD2), expressed on neuroblastoma cells. Blinatumomabspecifically targets the CD19 antigen present on B cells. Pem-brolizumab targets the programmed cell death 1 (PD-1) receptor. Avelumab targets the protein programmed death-ligand 1 (PD-L1).
Our 2016 Weinberg Symposium speaker Mignon Lohwas deeply involved in the successful pediatric clinical trialsof Blinatumomab.
Thanks to major support from Members, contributors toTeam Andrew Weinberg Boston Marathon Jimmy Fund Walk,and two major donations from Epizyme®, Inc., and Tufts’Physician Assistants Class of 2018, we are proud to announce:James E. Bradner, MD, President of the Novartis Institutes forBioMedical Research will give the 21st Andrew H. WeinbergMemorial Lecture on Wednesday, November 1, 2017 at 4:00
pm – 5:00 pm which will be simultaneously web streamed at:http://video.dfcionline.org/accordent/WeinbergSymposium110117Final information will be in the October issue of The Nucleus,online at MassBio’s event page and online in Whitehead In-stitute’s Biology Week.Donations are gratefully accepted at:http://www.jimmyfundwalk.org/2017/teamandrewweinbergThe Symposium Committee:James S. Weinberg, Ph.D., BioPhysics Assay Laboratory;Julie S. Weinberg, B.A., Tufts PA Class of 2018;Glenn Bubley, M.D., Beth Israel Deaconess Medical Center;Holcombe Grier, M.D., Dana-Farber Cancer Institute;Peter Ho, M.D., Ph.D., Epizyme, Inc.;Cigall Kadoch, Ph.D., Dana-Farber Cancer Institute;Steven DuBois, M.D., M.S., Dana-Farber Cancer Institute;Tracey Cook, M.A., Dana-Farber Cancer Institute. u
Approved Oncologic Drugs for PediatricUse 2015-2017By James S. Weinberg, Ph.D., Biophysics Assay Laboratory
Steven DuBois (back center) receiving $2,000 from the Tufts’Physician As-sistants Class Photo by Sam Ogden
Drug Oncology Drugs Approved- Indication
Dinutuximab (tradename Unituxin)
Neuroblastoma in combi-nation with GM-CSF andIL-2 and 13-cis retinoicacid
Blinatumomab (tradename Blincyto)
Relapsed/refractory acutelymphoblastic leukemia
Pembrolizumab (tradename Kaytruda)
Microsatellite instability-high solid tumors
Avelumab (tradename Bavencio)
Children 12 years of ageand older with Merkle cellcarcinoma
Source: Gregory H. Reaman, M.D., Associate Director, On-cology Sciences, U.S. Food and Drug Administration
Save the date!The 21st Andrew H. Weinberg
SymposiumNovember 1, 2017
Featuring James E. Bradner, MDPresident-Novartis Institutes for
BioMedical Research
The Weinberg Symposium was createdin honor of Andrew H. Weinberg, whodied of cancer before his third birthday.The Weinberg family, with support fromfamily and friends, as well as the Me-dicinal Chemistry Group of the North-eastern section of the AmericanChemical Society, created a fund in1995 to support the lecture. Through thissymposium, the Andrew H. WeinbergMemorial Endowment Fund brings to-gether researchers from the field of can-cer drug development and those in thebiomedical research and clinical carecommunities at large, helping to fosteran environment for synergy in advanc-ing the care of children with cancer. “The Weinberg Symposium plays a vitalrole in the oncology drug developmentlandscape. Bringing together research -ers from Universities, Medical Centersand Industry, it allows for creative dis-cussion among guests which is atypicalat traditional meetings. It also serves toinspire our next generation of thoughtleaders- the students who intend to pur-sue careers in this rapidly evolvingfield. ” —Graham Jones, PhD, Tufts Clinicaland Translational Science Institute (TuftsCTSI); Associate Director and Directorof Research Collaborations Tufts CTSI. “I am grateful for the opportunities theWeinberg symposium has provided as aforum for interaction and collaborationbetween my research program and someof the most prominent physicians andscientists in the field.”
— Alejandro Gutierrez, MD, Divisionof Hematology/Oncology at Children’sHospital Boston and the Department ofPediatric Oncology at Dana-Farber Can-cer Institute.“The Weinberg Symposium has been aunique venue that has brought togethera wide breadth of basic and clinical re-searchers from diverse settings rangingfrom academia, government and thepharmaceutical industry to promote thediscovery and development of new can-cer therapeutics for children. Whilethere exist many conferences that focuson similar objectives in adult malignan-cies, especially the ones most common,it is rare for this to occur in the settingof childhood cancers. It is for this rea-son that I look forward to hearing fromthe invited speaker each year.”— Peter Ho, MD, PhD, Chief MedicalOfficer, Epizyme, Inc.“I have been fortunate to be involvedwith the Weinberg Symposium since itsinception. There are several ways inwhich the event has brought meaning tome and to the field: James Weinberg hastaken a tragedy in his life and turned itinto a personal mission to improve thecare of children with cancer. He has uti-lized his own expertise (medicinal chem-istry) to put together a symposium thatcombines industry, academia and gov-ernment speakers. The speakers, to a one,understand this mandate, and bring newideas to the symposium allowing a betterunderstanding over the years of how can-cer treatment for children comes about.Our trainees meet with the speaker eachyear, allowing them personal insight intocancer drug development.”— Holcombe Grier, MD, Professor ofPediatrics, Clinical Oncology at Dana-Farber/Children’s Hospital Cancer Care
With advances in treatment and dis-coveries in basic science, about 90 per-cent of children with acute lymphocyticleukemia (ALL) are now long-term sur-
vivors. But that is no cause for compla-cency, an expert in the disease told anaudience at Dana-Farber on Sept. 28,2016.
Delivering the 20th Annual Wein-berg Symposium, Mignon Loh, MD,chief of Pediatric Hematology/Oncol-ogy at the University of California, SanFrancisco, discussed how researchersare translating recent discoveries intonew therapies for children, adolescents,and young adults with ALL.
“The mission for all of us is to iden-tify which patients can be cured with ourcurrent therapies, and what 21st centurymethodologies we can use to improvethe prospects for those at high risk oftreatment failure,” she said.
Strategies for improving treatmentare proceeding along four routes, she re-marked: 1.) identifying patients whomay benefit from targeted therapies; 2.)modifying therapy for patients who donot metabolize – or break down – cer-tain drugs normally; 3.) adjusting thera-pies to prevent or deter drug resistance;4.) determining which patients mightbenefit from immunotherapies. Threemajor trials are underway nationwide totest these approaches.This lecture webcast can be viewed at:http://video.dfcionline.org/accordent/WeinbergSymposium092816/Recent Weinberg Symposium lec-tures can be viewed at:The 18th Annual Andrew H. WeinbergAnnual Memorial LectureLuis Alberto Diaz, Jr., M.D AssociateProfessor, Oncology, Johns HopkinsSidney Kimmel Comprehensive CancerCenter and the Ludwig Center for Can-cer Genetics and Therapeutics, Novelclinical applications of cancer genomicshttp://video.dfcionline.org/accordent/Weinberg061914The 19th Annual Andrew H. WeinbergAnnual Memorial LectureGregory Reaman, M.D., Associate Di-
The Nucleus Summer/September 2017 9
20th Annual Weinberg SymposiumSpeaker: Mignon Loh, MD, the Benioff Professor of Clinical Pediatrics and Chief of Pediatric Hematology/Oncol-ogy at the University of California, San Francisco Benioff Children’s HospitalBy Steven DuBois, MD, MS, Director, Experimental Therapeutics Dana-Farber/Boston Children’s Cancer and Blood DisordersCenter and chair of the Weinberg Symposium Committee
Mignon Loh Photo by Sam Ogden.
continued on page 14
10 The Nucleus Summer/September 2017
HIGH SCHOOL AWARDSFIFTY-SIXTH ANNUAL AVERY A. ASHDOWN HIGH
SCHOOL EXAMINATION CONTESTStudent School TeacherFirst Place - The Simmons College AwardJoshua Park Lexington HS Janice ComptonSecond PlaceEvan Zeng Newton South HS Alan Crosby, Suzy
DrureyThird PlacePeter Wilson Acton Boxborough Eleni Kakaliou, David
BaumritterHonorable Mention First YearHenry J. Heffan Brookline HS Meaghan Cells, Alexis
MurphyBrian Xiao Groton School Sandra KellyBenjamin Choi Lexington HS Janice ComptonChris Q. Yang Winchester HS Xiaojie Zhou, David
BaumritterNathan Elbaum Newton South HS Alan Crosby, Marianne
McChesneyHonorable Mention Second YearEric You Phillips Academy Kevin Cardozo, Brian
FaulkGautam Ramesh Phillips Exeter Academy Michael H. McLaughlin,
Alison HobbieAndrew Tsakiris Acton-Boxborough, Mrs. Kakaliou, Mr.
BaumritterSamuel He Phillips Academy, Andover Kevin Cardozo,
Brian FaulkAlexandra Hoey Concord - Carlisle Betsy Meeks, Cricket
McCaffrey
AULA LAUDIS SOCIETYLorraine Zanini Algonquin Regional High School David Belmarsh Newton North High SchoolRosemary White Boston University Academy
Theodore William Richards Award for Excellence inTeaching Secondary School Chemistry
Jay Chandler Wayland High School
Remaining USNCO QualifiersHasan M. Khan Sharon High SchoolAlex H. Zhong Wayland High SchoolAndrew N. Garber Cambridge Rindge and Latin SchoolAlex Y. Zhu Wayland High SchoolAndrew Mulholland Masconomet High SchoolCaleb Trotz Acton - BoxboroughCheng W. Jin Winchester High SchoolInyoung Choi St. Paul’s SchoolSoo Hyun Kim St. Paul’s SchoolJillian O’Neil Concord - Carlisle High SchoolElizabeth Qian-Wang Dover - Sherborn High SchoolYuxuan (Tom) Zhang Boston University High SchoolBeth LaMacchia Andover High SchoolJuliana Katz Masconomet High School
COLLEGE AND UNIVERSITY AWARDS2017 UNDERGRADUATE RESEARCH SCHOLARS,
JAMES FLACK NORRISAnd THEODORE WILLIAM RICHARDS SCHOLARS
Abraham Bayer Tufts UniversityRebecca Scheck, AdvisorWilliam Coreas Stonehill CollegeDeno Del Sesto, AdvisorSewon Oh Boston CollegeJeffrey A. Byers, AdvisorRachael Howland UMass – DartmouthPatrick Cappillino, Advisor
DR. PHYLLIS A BRAUNER MEMORIAL BOOK AWARDYimin Zhang Tufts UniversitySamuel W. Thomas III, Advisor u
Education Night Awards Photos by Morton Z. Hoffman
A123 Systems, Waltham, MA - May 11, 2017The Board of Directors of NESACS would like to thank A123 Systems for the opportunity to hold our Education Night Eventat A123 Systems this year.
Chris Campion (L), Senior Research Scientist at A123 Systems, welcomesthe attendess to A123 Systems. Sarah McCord (R), Associate professor atMCPHS Univesity gave the keynote talk on data management in chemistry.
Q. Exactly, how many awards and scholarships does NESACS sponsor?
A) One b) Two c) Many
www.nesacs.org/awards
The NSCRC took place on April 8th 2017 in the ChemistryBuilding at Harvard University. We had 137 people registeredfor the day from 23 different universities and colleges. Oneof the measurements of our success this year was establishinga point of contact at each university in the Northeastern Sec-tion. This allowed us to cast a wider net and spread the wordabout the conference and other great events organized by theNSYCC to a wide range of schools. Another important aspectof our conference this year was welcoming students from di-verse chemistry backgrounds. The day was comprised of 6talks, 66 posters and 7 elevator pitches. Judges voted on sixdifferent prestigious awards including best talk and best posterfor undergraduate and graduate students. At the end of the dayour sponsored monetary awards were given to those selected:Oral Presentation Awards:Xuyu Tan, Northeastern University - Outstanding Oral Pres-entation Award sponsored by Strem ChemicalsJohn de la Parra, Northeastern University - Excellent ElevatorPitch Award sponsored by JEOL USA, Inc.Poster Awards:Bilyana Koleva, Northeastern University - Outstanding Grad-uate Student Poster sponsored by Strem ChemicalsJasper Du, Tufts University - Outstanding Undergraduate Stu-dent Poster sponsored by JEOL USA, Inc.Other Awards:Reem Telmesani, Boston University - Most Promising FemaleScientist Award sponsored by Graduate Women in ScienceYimin Zhang, Tufts University - The Phyllis A. Brauner Me-morial Book Award sponsored by the Northeastern Section ofthe American Chemical Society Committee on Chemistry Ed-ucation
Many thanks to our judges Dr. Mindy Levine, Dr. ThomasGilbert, Dr. Carol Mulrooney and Dr. Sofia Santos from NE-SACS, as well as Dr. Tian He from Harvard University, fortheir participation and hard work! Due to the current political climate and the increased interestof young chemists in science policy as well as their desire toget more involved in government affairs and have the powerto make a difference outside of the lab, we invited Dr. LauraE. Pence from the University of Hartford as our keynotespeaker. Dr. Pence, a Professor of Chemistry and an electedmember of the American Chemical Society Board of Directorsfrom District I, spent a year as an ACS/American Associationfor the Advancement of Science (AAAS) Congressional Sci-ence Policy Fellow in the office of Sen. Michael Bennet (D-CO), where her policy portfolio featured natural resources,energy, and environmental issues, with a particular emphasisin the areas of water and forestry. Dr. Pence’s keynote addresson “Science Policy in a Post-Fact World” was very engagingand sparked a productive interaction with the audience.
The Nucleus Summer/September 2017 11
19th Annual Northeast StudentChemistry Research Conference (NSCRC)By Sofia Santos, PhD, 2016-2017 Career Chair of NSYCC, Photos by Brian D’Amico
Award winners from the NSCRC conference held at Harvard University:(L-R) Reem Telmesani (Boston University), Jasper Du (Tufts University),Yimin Zhang (Tufts University), Bilyana Koleva (Northeastern University),John de la Parra (Northeastern University), Xuyu Tan (Northeastern Uni-versity).
The judges of the NSCRC (L-R) Mindy Levine, Tian He, Sofia Santos,Carol Mulrooney and Thomas Gilbert.
Dr. Laura Pence Q&A
continued on page 14
12 The Nucleus Summer/September 2017
Rachael Howland (University of Massachusetts Dartmouth), recipient of aJames Flack Norris and Theodore William Richards Scholarship, flankedby her research advisor, Patrick Cappillino, at right, and Ruth Tanner(University of Massachusetts Lowell), Acting Chair, NESACS EducationCommittee.
Remaining Qualifiers for the United States National Chemistry OlympiadTeam: (l-r) Andrew Mulholland (Masconomet High School), Andrew Gar-ber (Cambridge Rindge and Latin School), Juliana Katz (MasconometHigh School), Hasan Khan (Sharon High School), Beth LaMacchia (An-dover High School)
Second Place in the Ashdown Exam: Evan Zeng (Newton South HighSchool), at right, with Steve Lantos (Brookline High School), Chair, NE-SACS High School Education Committee, at right.
Initiation into the Aula Laudis Society: Lorraine Zanini (Algonquin Re-gional High School), at left, and Rosemary White (Boston UniversityAcademy), second from the right, with Ann Lambert (King Phillip Re-gional High School, Chair, Aula Laudis Society, and Steve Lantos, at right.
Third Place in the Ashdown Exam: Peter Wilson (Acton-Boxborough Re-gional High School), at left, with Steve Lantos
Sewon Oh (Boston College), recipient of a James Flack Norris andTheodore William Richards Scholarship, flanked by his research advisor,Jeffrey Byers, at left, and Ruth Tanner
Education Night AwardsContinued from page 10
HistoricalNoteJean-Pierre Anselme1936–July 12, 2017I knew J.-P. through my earlier years atPolaroid. He was very good friends withResearch Director Lloyd Taylor andLloyd hired many of his students. Thebest known is John Warner, hired afterJohn received his Ph. D. from Ted Tay-lor at Princeton. But I also worked andin one case supervised a former studentof his, the irrepressible, Bill Collibee, ofEverett who bounced between chem-istry and pharmacy but ended up back at
his roots as a bench chemist after return-ing to J.-P. to get a master’s degree. Oneof my first labmates at Polaroid wasCharlie Hammond, another of J.P.’s stu-dents, as well as Cathy (Keane) Palumbowho became our NMR spectroscopist.His legacy at Polaroid was substantialand he was loved and respected by thosewho knew him. There is a wonderfulobituary at the Roberts-Mitchell FuneralHome in Medfield, MA. https://obittree.com/obituary/us/massa-c h u s e t t s / . . . / j e a n - p i e r r e —anselme/2981218/index.phpSome excerpts from that obituary:
Professor Emeritus Jean-PierreAnselme was born in Port-Au-Prince,Haiti in 1936. While growing up in Haiti
he lost his mother at the age of 12, butdespite his loss he persevered to immi-grate to the United States in 1955 tostudy Chemistry at Fordham Universityand later earn his Ph.D. from BrooklynPolytechnic Institute of New York in1961. J.-P. was a Professor of Chemistryat the University of Massachusetts atBoston for over 43 years. He foundedOrganic Preparations and ProceduresInternational and was Executive Editoruntil his passing.
J.-P. was a mentor and an inspira-tion to many students who went on tosuccessful careers in Chemistry and inother sciences including medicine. In1980, he was awarded the DistinguishedImmigrant Award from President Rea-
The Nucleus Summer/September 2017 13
Head Table (l to r): Dr. Karl Hansen of Amgen and Chair of the 2017 Es-selen Award Committee, Leland Johnson Chair of NESACS, Dr. James An-derson of Harvard University and 1991 Esselen Awardee, Dr. Neil M.Donahue of Carnegie Mellon and the 2017 Awardee, Dr. Donahue's wifeDr. Maren Donahue and their daughter Ms. Kielan Donahue
Representing the Esselen family standing (L-R): Mr. Malcolm Bell and hiswife Mrs. Nancy Bell and Mrs. Joanna Hanson Stengle. Seated l to r: Mrs.Joan Esselen Foot and her husband Mr. Silas B. Foot III, Mrs. CatherineEsselen and her husband Mr. Gustavus John Esselen IV, the presenter ofthe award. He and his sister, Mrs. Joan Foot, are the children of thefounder of the award.
Esselen Award Photos by Joel Laino
Standing (L-R): Dr. Paul Vouros, Dr. Martin Idelson, Dr. Paulette Idelson,Mrs. Irene Vouros and Dr. Anna Sromek. Seated l to r: Dr. John Neumeyer,Mrs. Rose Simon and Dr. Myron Simon. All are past chairs of the EsselenAward Committee and dedicated supporters of the award.
Representing the Esselen family standing l to r: Mr. G. McKenzie Gordonand his wife Mrs. Dorothy Bachrach Gordon and seated l to r: Dr. LauraBachrach, Mr. Peter Gamble and Dr. William Bachrach.
continued on page 14
14 The Nucleus Summer/September 2017
D I R E C T O R Y
SERVICES
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rector of Oncology Sciences Office ofHematology and Oncology ProductsCenter for Drug Evaluation and Re-search, U.S. Food and Drug Administra-tion, and Professor of Pediatrics GeorgeWashington University School of Med-icine and Health Sciences, “Drug Devel-opment for Pediatric Cancers – TurningChallenges into Opportunities: A Viewfrom the Other Side”http://video.dfcionline.org/accordent/2015WeinbergSymposium102915 u
Weinberg SymposiumContinued from page 9
NSCRCContinued from page 11
Garages. If a visitor parks at either ofthese garages he/she will need to obtainan hourly validation ticket at the 35Landsdowne, 40 Landsdowne, 300Mass. Ave. or 350 Mass. Ave. receptiondesk. Without the hourly validationticket, visitors and anyone not pos-sessing a monthly parking card willbe charged a flat $40 fee no matter theduration of the visit. u
Monthly MeetingContinued from page 5
merization, organometallic chemistry,organic opto-electronic materials, andelectronically functional metal oxides.”The winner of the 2016 James FlackNorris Award for Outstanding Achieve-ment in the Teaching of Chemistry fromNESACS, Thomas Holme, Iowa StateUniversity, received the George C. Pi-mentel Award in Chemical Educationsponsored by Cengage Learning and theACS Division of Chemical Education:“For his pioneering work in developingcurriculum materials for pre-engineer-ing students and advancing our under-standing of measurement of studentlearning in chemistry.”Other NESACS members who assistedwith award presentations were Kather-ine Lee, Pfizer, Inc.; ChristopherBauer, University of New Hampshire;Ephraim Honig, Strem Chemicals;Jennifer Maclachlan, PID Analyzers;Dorothy Phillips, ACS Board of Direc-tors. u
NESACS 2017 AwardsContinued from page 6
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Historical NoteJean-Pierre AnselmeContinued from page 13
The Nucleus Summer/September 2017 15
CAREER SERVICESSERVICES
B U S I N E S S D I R E C T O R Y
SERVICES
Index of AdvertisersEastern Scientific Co. ......16Micron, Inc. .....................15Northeastern University ....2NuMega Resonance Labs15Organix, Inc. ....................15PCI Synthesis.....................6Robertson Microlit Labs..15Tyger Scientific, Inc. .......15
Check the NESACS home pagefor late Calendar additions:http://www.NESACS.orgNote also the Chemistry Department webpages for travel directions and updates.These include:http://www.bc.edu/schools/cas/chemistry/s
eminars.htmlhttp://www.bu.edu/chemistry/seminars/http://www.brandeis.edu/departments/chem
istry/events/index.htmlhttp://chemistry.harvard.edu/calendar/upco
minghttp://www.northeastern.edu/cos/chemistry/
events-2/http://chemistry.mit.edu/events/allhttp://chem.tufts.edu/seminars.htmlhttp://engineering.tufts.edu/chbe/newsEven
ts/seminarSeries/index.asphttp://www.chem.umb.eduhttp://www.umassd.edu/cas/chemistry/http://www.uml.edu/Sciences/chemistry/Se
minars-and-Colloquia.aspxhttp://www.unh.edu/chemistry/eventshttps://www.wpi.edu/academics/departments/che
mistry-biochemistry
September 7Prof. John R. Reynolds (Georgia Tech)MIT, Room 6-120, 4:00 pmProf. Alex Dieters (Pittsburgh)Boston College, Merkert 130, 4:00 pm
September 8Prof. Donna Blackmond (Scripps Research Insti-tute)Boston College, Merkert 130, 4:00 pm
September 9Prof. Donna Blackmond (Scripps Research Insti-tute)Boston College, Merkert 130, 4:00 pm
September 12Prof. Steve Buchwald (MIT) Harvard, Pfizer Lecture Hall, 4:15 pmProf. Yoshito Kishi (Harvard)Boston College, Merkert 130, 4:00 pm
September 13Prof. Yimon Aye (Cornell)Boston College, Merkert 130, 4:00 pmProf. Anita Mattson (Worcester PolytechnicInstitute)“Catalyst Design, Method Development, andComplex Molecule Synthesis.”Northeastern, 129 Hurtig Hall, 12:00 pm
September 14Prof. David MacMillan (Princeton)Boston College, Merkert 130, 4:00 pm
September 15Prof. David Liu (Harvard)Boston College, Merkert 130, 4:00 pm
September 18Prof. Shana Kelley (Toronto)Harvard, Pfizer Lecture Hall, 4:15 pm
September 19Prof. Donna Chen (South Carolina)Tufts, Pearson, Rm. P106, 4:30 pmProf. Jack Norton (Columbia)Boston College, Merkert 130, 4:00 pm
September 20Prof. Stephen Ragsdale (Michigan)“The Roles of Metal Ions in Biology.”Northeastern, 129 Hurtig Hall, 12:00 pm
September 21Prof. David Tirrell (Cal Tech)Boston College, Merkert 130, 4:00 pm
September 25Prof. Emily Balskus (Harvard)Harvard, Pfizer Lecture Hall, 4:15 pm
September 26Prof. Bonnie Bassler (Princeton) Tufts, Pearson, Rm. P106, 4:30 pmProf. Jeff Long (UCal-Berkeley)Harvard, Pfizer Lecture Hall, 4:15 pmProf. Christine Thomas (Brandeis)Boston College, Merkert 130, 4:00 pm
September 27Prof. Eric Brustad (North Carolina)Boston College, Merkert 130, 4:00 pmProf. Leslie Hicks (North Carolina)“Proteomics, Post-translational Modifications,and Mass Spectrometry.”Northeastern, 129 Hurtig Hall, 12:00 pm
September 28Prof. Tom Maimone (UCal-Berkeley)MIT, Room 6-120, 4:00 pm
Notices for The NucleusCalendar of Seminars should besent to:Xavier Herault, email:[email protected] u
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