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[ A N N O U N c E M E N T S I 0 CONTENTS OF OTHER CANCER JOURNALS 0

CANCER RESEARCH VOL. 43, No. 7, 1983 Editorial Office: Fels Research Institute, Temple University School of Medicine, Philadelphia, PA 19140, USA

Editorial, by P.N. Magee. Role of Retinoids in Differentiation and Carcinogenesis, by Michael B. Sporn and Anita B. Roberts. Effect of Hyperglycemia on Thermochemotherapy of a Spontaneous Murine Fibrosarcoma, by M. Urano and M.S. Kim. Inhibition of 7-Bromomethylbenz(a)anthracene-promoted Mouse Skin Tumor Formation by Retinoic Acid and Dexamethasone, by Ajit K. Verma, C.T. Garcia, Curtis L. Ashendel and R.K. Boutwell. Effect of Tumor Size on S-2-(3-Aminopropylamino)ethylphos- phorothioic Acid and Misonidazole Alteration of Tumor Response to Cyclophosphamide, by Luka Milas, Hisao 1to and Nancy Hunter. Generation of Phenotypic Diversity in the B16 Mouse Melanoma Relative to Spontaneous Metastasis, by Christopher W. Stackpole. Human NH, Terminal of Pro-opiomelanocortin as a Potential Marker for Pulmonary Carcinoma, by John S.D. Chan, Nabil G. Seidah and Michel Chretien. Potentiation of DNA-reactive Antineoplastic Agents and Protection against S-Phase-specific Agents by Anguidine in Chinese Hamster Ovary Cells, by Robert Hromas, Barthel Barlogie, Douglas Swart- zendruber and Benjamin Drewinko. Uptake, Initial Effects, and Chemotherapeutic Efficacy of Hamng- tonine in Murine Leukemic Cells Sensitive and Resistant to Vicris- tine and Other Chemotherapeutic Agents, by Ting-Chao Chou, Franz A. Schmid, Aaron Feinberg, Frederik S. Philips and Jui Han. Metabolism of Acrylonitrile by Isolated Rat Hepatocytes, by Lee E. Geiger, Lora L. Hogy and F. Peter Guengerich. Chemotherapy and Radiation Therapy of Human Medulloblastoma in Athymic Nude Mice, by Henry S. Friedman, S. Clifford Schold, Jr., Mahesh Varia and Darell D. Bigner. Characterization and Quantitation of Antiestrogen Binding Sites in Estrogen Receptor-positive and negative Human Breast Cancer Cell Lines, by Margaret Ann Miller and Benita S. Katzenellenbogen. Tumoricidal Effects of Sodium Hexachloroiridate on an Ascitic Tumor in Mice, by Gerald M. Kolodny and Christopher Rose. Effect of 3-Aminobenzamide on the Rate of Ligation during Repair of Alkylated DNA in Human Fibroblasts, by William F. Morgan and James E. Cleaver. Experimental Hyperthermic Isolation-Perfusion Using cis-Diam- minedichloroplatinum(II), by Allan G. Wile, Maurice Y. Nahabe- dian, Donald A. Plumley, J. Edward Guilmette and G. Robert Mason. Some Advantages of Curing Mice Bearing a Large Subcutaneous MOPC-315 Tumor with a Low Dose Rather Than a High Dose of Cyclophosphamide, by Margalit B. Mokyr and Sheldon Dray. Role of the Acetylation Polymorphism in Determining Susceptibility of Cultured Rabbit Hepatocytes to DNA Damage by Aromatic Amines, by Charlene A. McQueen, Carol J. Maslansky and Gary M. Williams. Effect of Hyperthermia on the Survival of Normal Human Peripheral Blood Mononuclear Cells, by Shyam S. Agarwal, Edward J. Katz and Lawrence A. Loeb. Absence in Glucocorticoid-resistant Mouse Lymphoma PI798 of a Glucocorticoid Receptor Domain Responsible for Biological Effects, by Sam Okret, Yee-Wan Stevens, Jan Carlstedt-Duke, Orjan Wrange, Jan-Ake Gustafsson and John Stevens. Identification and Mutagenicity of Metabolites of 1-Nitropyrene Formed by Rat Liver, by Karam El-Bayoumy and Stephan S. Hecht. Influence of Heat on the Intracellular Uptake and Radiosensitization of 2-Nitroimidazole Hypoxic Cell Sensitizers in Vim, by Dennis M. Brown, Mark S. Cohen, Robert H. Sagerman, Ricardo Gonzalez- Mendez, George M. Hahn and J. Martin Brown.

A Fast and Convenient Method for Determining Estrogen Receptor Using Rabbit Uterus as a Standard, by J. Mukharji, N.Y. Zachariah, Z.H. Chakmakjian and G.J. Race. Comparison of in Vitro Methods for Assessing Cytotoxic Activity against Two Pancreatic Adenocarcinoma Cell Lines, by Barbara K. Chang. Nuclear Thyroid Hormone Receptors, a-Glycerophosphate Dehyd- rogenases, and Malic Enzyme in N-Nitrosomethylurea-induced Rat Mammary Tumors, by Frank J. Ruzicka and David P. Rose. Monoclonal Antibodies to Human Melanoma-associated Antigens: An Amplified Enzyme-linked Immunoabsorbent Assay for the De- tection of Antigen, Antibody and Immune Complexes, by Alton C. Morgan, Jr., and Robert F. McIntyre. Low Oral Bioavailability of Hexamethylmelamine in the Rat Due to Simultaneous Hepatic and Intestinal Metabolism, by Pierre J. Klip- pert, Abram Hulshoff, Marie-Jose J. Mingels, Gerard Hofman and Jan Noordhoek. Effects of Ultraviolet Irradiation in the Presence of Melanin Isolated from Human Black or Red Hair upon Ehrlich Ascites Carcinoma Cells. I. Aravindakshan Menon, Surujdeen Persad, Narendranath S. Ranadivc and Herbert F. Haberman. Prolactin-like Activity of Antiprolactin Receptor Antibodies in Rat Mammary Tumor Explants, by Marc Edery, Jean Djiane, Louis- Marie Houdebine and Paul A. Kelly. Mechanism of Sensitization of Chinese Hamster Ovary Cells to Mel- phalan by Hypoxic Treatment with Misonidazole, by Yvonne C. Tay- lor, James W. Evans and J. Martin Brown. Use of Uridine Rescue to Enhance the Antitumor Selectivity of S- Fluorouracil, by Philip Klubes and Ingeborg Cerna. Systemic Lidocaine Enhancement of Hyperthermia-induced Tumor Regression in Transplantable Murine Tumor Models, by H. Ian Ro- bins, Warren H. Dennis, James S. Slattery, Thomas A. Lange and Milton B. Yatvin. Combination Chemotherapy Involving a-Difluoromethylornithine and l+J-Arabinofuranosylcytosine in Murine L1210 Leukemia, by Nellikunja J. Prakash and Prassad S. Sunkara. Role of Lipid Transfer Proteins in the Abnormal Lipid Content of Moms Hepatoma Mitochondria and Microsomes, by Richard C. Crain, Ronald W. Clark and Brian E. Harvey. Modulation of Involucrin and Envelope Competence in Human Keratinocytes by Hydrocortisone, Retinyl Acetate, and Growth Ar- rest, by Polly R. Cline and Robert H. Rice. Effects of Combination Estrogen:Cyclophosphamide Treatment on the Growth of the MXT Transplantable Mammary Tumor in the Mouse, by B.M. Markaverich, D. Medina and J.H. Clark. Involvement of both Syn- and Anri-Dihydrodiol-Epoxides in the Binding of 7,12-Dimethylbenz(a)anthracene to DNA in Mouse Em- bryo Cell Cultures, by Josef T. Sawicki, Robert C. Moschel and An- thony Dipple. Divergent Effects of Retinoids on Pancreatic and Liver Car- cinogenesis in Azaserine-treated Rats, by Daniel s. Longnecker, Elna T. Kuhlmann and Thomas J. Curphey. Effects of Four Retinoids in N-Nitrosobis(2-oxopropyl)amine-treated Hamsters, by Daniel S. Longnecker, Elna T. Kuhlmann and Thomas J. Curphey. Interaction of Ultrasonic Hyperthennia with Two Alkylating Agents in a Murine Bladder Tumor, by Frank W. Longo, Philip Tomashefs- ky, Bernard D. Rivin and Myron Tannenbaum. Weak Promotion of C3WlOTYa Cell Transformation by Repeated Treatments with Formaldehyde, by Janet H. Frazelle, Diane J. Aber- nethy and Craig J. Boreiko.

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Thermal Survival Characteristics of Cell Subpopulations Isolated from a Heterogeneous Human Colon Tumor, by John T. Leith, Philip Heyman, J. Keith DeWyngaert, Daniel L. Dexter, Paul Calabresi and Arvin S . Glicksman. 06-Methylguanine-DNA Methyltransferase of Human Lymphoid Cells: Structural and Kinetic Properties and Absence in Repair-defi- cient Cells, by Adrian L. Hams, Peter Karran and Tomas Lindahl. Murine Metabolism and Disposition of 1ron:Adriamycin Complexes, by Merill J: Egorin, Ronald E. Clawson, Louis A. Ross, Rosalind D. Friedman, Steven D. Reich, Avrom Pollak and Nicholas R. Bachur. Loss of Tumorigenicity of Lewis Lung Carcinoma on the Chorioallan- toic Membrane of the Chick Embryo, by D. Belin and L. Ossowski. Direct and indirect Clastogenic Activity of Anthracenedione in Chin- ese Hamster Ovary Cells, by Lany J. Rosenberg and Walter N. Hit- telman. Fluorescent Nitroheterocycles for Identifying Hypoxic Cells, by Peg- gy L. Olive and Ralph E. Durand. Stimulation of Increased Capillary Endothelial Cell Motility by Chon- drosarcoma Cell-derived Factors, by J. Azizkhan, R. Sullivan, R. Azizkhan, B.R. Zetter and M. Klagsbrun. Clonal Chromosome Changes in Stimulated Lymphocytes of Untre- ated Human B-Cell Leukemias, by Naoki Sadamori, Tin Han, Jun Minowada, Sei-ichi Matsui and Avery A. Sandberg. Organ-specific Promoting Effect of Phenobarbital and Saccharin in Induction of Thyroid, Liver, and Urinary Bladder Tumors in Rats after Initiation with N-Nitrosomethylurea, by Hiroyuki Tsuda, Shoji Fukushima, Katsumi Imaida, Yasushi Kurata and Nobuyuki Ito. Comparison of Soluble Protein Kinases from Normal Rat Prostates and Prostatic Dunning Tumors, by Leland W.K. Chung and Karen Breitweiser. Immunocytochemical Demonstration of Hormonally Regulable Ca- sein in Tumors Produced by a Rat Mammary Stem Cell Line, by Philip S . Rudland, Christine M. Hughes, Anna C. Twiston Davis and Michael J. Warburton. Nononcogenic Hormone-independent Alveoli Produced by Carcino- gens in Cultured Mouse Mammary Glands, by Frederick V. Schaefer, Quentin J. Tonelli, Michael S. Dickens, R. Philip Custer and Sam Sorof. 06-Methylguanine Removal by Competent and Incompetent Human Lymphoblastoid Lines from the Same Male Individual, by Robert M. Sklar and Bemard S. Strauss. Activation of Cyclic Adenosine 3’:5’-Monophosphatedependent Pro- tein Kinase in H35 Hepatoma and Chinese Hamster Ovary Cells by a Phorbol Ester Tumor Promoter, by Craig V. Byus, James M. Trevil- lyan, Leslie J. Cavit and William H. Fletcher. Demonstration of Complex Antigenic Heterogeneity in a Human Glioma Cell Line and Eight Derived Clones by Specific Monoclonal Antibodies, by Carol J. Wikstrand, Sandra H. Bigner and Darell D. Bigner. Isolation and Characterization of Endoplasmic Reticulum and Golgi Apparatus from Hepatocpe Nodules in Male Wistar Rats, by Lennart C. Eriksson, Ulla-Britta Torndal and Goran N. Andersson. Alterations of Human Endometrial Stromal Cells Produced by N- Methyl-N-nitro-N-nitrosoguanidine, by B. Hugh Dorman, Jill M. Siegfried and David G. Kaufman. Estimation of the Number of Genes Specifiying the Heavy Chain of Mouse Thymus Leukemia Antigens, by Ryszard Slomski, Christine L. Martens and Edward P. Cohen.

Regional Measurements of Blood Flow in Experimentation RG-2 Rat Gliomas, by Dennis R. Groothuis, Joseph F. Pastemak, Joan M. Fischer, Ronald G. Blasberg, Darell D. Bigner and Nicholas A. Vick. Regional Measurements of Blood-to-Tissue Transport in Experimen- tal RG-2 Rat Gliomas, by Dennis R. Groothuis, Joan M. Fischer, Joseph F. Pastemak, Ronald G. Blasberg, Nicholas A. Vick and Darell D. Bigner. Effect of Size on Portal Circulation of Hepatic Nodules from Carcino- gen-treated Rats, by James G. Conway, James A. Popp, Sungchul Ji and Ronald G. Thurman. Characterization of a Differentiated Cat Melanoma Cell Line, by Suraiya Rasheed. Calcium Modulation of Phorbol Ester-induced Alteration in Murine Macrophage Morphology, by Bonita M. Smith, Robert J. Sturm and Richard A. Carchman. Treatment of Mouse Mammary Tumors Using Combined Hyperther- mia and Ischemia, by Geraldine M. Baker and Eric A. Wright. Immunoprecipitation as a Tool for Studying Humoral Immunity of Natural and Experimental Hosts of Herpesvirus saimiri, by Susanne Modrow, Helga Schmidt and Hans Wolf. Multivariate Analysis of Prognostic Variables in Patients with Metas- tatic Testicular Cancer, by George J. Bosl, Nancy L. Geller, Const- ance Cirrincione, Nicholas J. Vogelzang, B.J. Kennedy, Willet F. Whitmore, Jr., Davor Vugrin, Howard Scher, Jerome Nisselbaum and Robert B. Golbey. Paradoxical Effects Associated with Supranormal Urinary Testos- terone Excretion in Premenopausal Women with Breast Cancer: In- creased Risk of Postmastectomy Recurrence and Higher Remission Rate after Ovariectomy, by Giorgio Secreto and Barnett Zumoff. Pharmacokinetics of N‘-Behenoyl-l-fi-~-arabinofuranosylcytosine in Patients with Acute Leukemia, by Takanori Ueda, Toru Nakamura, Seisho Ando, Daizaburo Kagawa, Masataka Sasada, Haruto Uchino, Ikuo Johno and Yuichi Akiyama. Plasma Pharmacokinetics of Adnamycin and Adriamycinol: Implica- tions for the Design of in V i m Experiments and Treatment Protocols, by Raymond F. Greene, Jerry M. Collins, Jean F. Jenkins, James L. Speyer and Charles E. Myers. Human Pharmacokinetics of a New Acridine Derivative, 4‘-(9-Ac- ridiny1amino)methanesulfon-m-anisidide (NCS 249992), by Stephan W. Hall, Jacqueline Friedman, Sewa S . Legha, Robert S. Benjamin, Jordan U. Gutterman and Ti Li Loo. Patterned Distribution of Metastases from Malignant Melanoma in Humans, by S.M. de la Monte, G. William Moore and Grover M. Hutchins. In Vivo Drug Sensitivity Assay of Clonogenic Human Melanoma Cells and Correlation with Treatment Outcome, by John M. Kirk- wood and John C. Marsh. Aberration of Poly(Adenosine Diphosphate-Ribose) Metabolism in Human Colon Adenomatous Polyps and Cancers, by Kiyoshi Hirai, Kunihiro Ueda and Osamu Hayaishi. Comparison of Electron Paramagnetic Resonance and Atomic Ab- sorption Serum Copper Measurements in Human Normal Control and Cancer Patients, by F.W. Kleinhans, Samuel C. Kline, William M. Dugan, Jr., and James G. Williams. S-Adenosylhomocysteine Catabolism and Basis for Acquired Resist- ance during Treatment of T-cell Acute Lymphoblastic Leukemia with 2’-Deoxycoformycin Alone and in Combination with 9-fi-~- Arabinofuranosyladenine, by Michael S. Hershfield, Nicholas M. Kredich, Charles A. Koller, Beverly S . Mitchell, Joanne Kurtzberg, Thomas R. Kinney and John M. Falletta.

CANCER RESEARCH - VOL. 43, NO. 8, 1983 Editorial Office: Fels Research Institute, Temple University School of Medicine, Philadelphia, PA 19140, USA

Editorial, by P.N. Magee. Biochemical Strategy of Cancer Cells and the Design of Chemotherapy. G.H.A. Clowes Memorial Lecture, by George Weber. Inhibition of DNA Methylation in L1210 Leukemic Cells by 5-Aza-2’- deoxycytidine as a Possible Mechanism of Chemotherapeutic Action, by Vincent L. Wilson, Peter A. Jones and Richard L. Momparler. Ketone Body, Glucose, Lactic Acid, and Amino Acid Utilization by Tumors in Vivo in Fasted Rats, by Leonard A. Sauer and Robert T. Dauchy.

Toxicity of Methyldopa (Aldomet) to Mouse Neuroblastoma Cells in Vivo, by Ewa Chelmicka-Schorr, Michael G. Sportiello, Gillis R. Otten and Barry G. W. Amason.

Demonstration of Immunogenecity with the Poorly Immunogenic B16 Melanoma, by Cihanghir Calik, David A. Lewis and Martin H. Goldrosen.

Comparison of the Sister Chromatid Exchange and Cell Survival As- says as a Measure of Tumor cell Sensitivity in Virro to cis-Diam- minedichloroplatinum(II), by Philip J. Tofilon, Mary E. Williams, Mary Helen Barcellos and Dennis F. Deen.

262

Kinetics of Adenosine 3’5’-Monophosphate-dependent Protein Kin- ase Activation and Inhibition of Thymidine Incorporation into DNA in P1798 Lymphosarcoma Cells, by Carolyn A. Michnoff, Becky A. de la Houssaye and Ruthann A. Masaracchia.

Effects of Extreme Hypoxia on the Growth and Viability of EMT6/SF Mouse Tumor Cells in Vitro, by Dennis C. Shrieve, Dennis F. Deen and John W. Harris. Relationship of Adriamycin Concentrations to the DNA Lesions in- duced in Hypoxic and Euoxic L1210 Cells, by Milan Potmesil, Stanley Kirschenbaum, Mervyn Israel, Mark Levin, Vinod K. Khetarpal and Robert Silber. Reduction of Estrogen Receptor Concentration in MCF-7 Human Breast Carcinoma Cells following Exposure to Chemotherapeutic Drugs, by Kuo-Pao Yang and Naguib A. Samaan.

Time-Dose Relationships for Simultaneous Misonidazole and 1,3- Bis(2chloroethyl)-l-nitrosourea Exposures in Vitro, by Timothy Mulcahy and Nancy Dembs. Mutagenicity and Cytotoxicity of Five Antitumor Ellipticines in Mam- malian Cells and Their Structure-Activity Relationships in Salmonel- la, by David M. DeMarini, Suzy Cros, Claude Paoletti, Pierre Lecointe and Abraham W. Hsie. In Virro Sensitivity to Steroid Hormones and Cytotoxic Agents of Normal and Malignant Lymphocyte Colony-forming Cells, by Ray- mond Taetle, Dong To and John Mendelsohn. Effect of the Prostaglandin Synthetase Inhibitor Indomethacin on 7,12-Dimethylbenz(a)anthracene-induced Mammary Tumorigenesis in Rats Fed Different Levels of Fat, by Christopher A. Carter, Richard J. Milholland, Wendy Shea and Margot M. Ip.

Specific Binding of [ 3H]Phorbol Dibutyrate to Phorbol Diester-re- sponsive and -resistant Clones of a Human Myeloid Leukemia (KG-1) Line 1, by Robert 1. Lehrer, Lenore E. Cohen and H. Philip Koeffler. Biological Effects and Structure-Activity Relationships of 1,2-Dihyd- ropyrido(3,4-b)pyrazines, by Glynn P. Wheeler, Bonnie J. Bowdon, Carroll Temple, Jr., Doris J. Adamson and Joliet Webster.

Differential Potentiation of 1,3-Bis(2-chloroethyl)-l-nitrosourea by a-Difluoromethylomithine in Chloroethylnitrosourea-sensitive and -resistant 9L Rat Brain Tumor Cells in Vitro, by Stina M. Oredsson, Philip J. Tofilon, Burt G. Feuerstein, Dennis F. Deen, Mark L. Rosenblum and Laurence J. Marton. Metabolic Activation of Styrene by Erythrocytes Detected as In- creased Sister Chromatid Exchanges in Cultured Lymphocytes, by Hannu Norppa, Harri Vainio and Marja Sorsa.

Effects of Tamoxifen on Human Breast Cancer Cell Cycle Kinetics: Accumulation of Cells in Early GI Phase, by C. Kent Osbome, David H. Boldt, Gary M. Clark and Jeffrey M. Trent. Double Determinant Immunoassay to Measure a Human High- molecular-weight Melanoma-associated Antigen, by Patrizio Giaco- mini, Ah Kau Ng, Raphe R.S. Kantor, Pier Giorgio Natali and Sol- dano Ferrone. Effects of Vincristine on Cell Survival, Cell Cycle Progression, and Mitotic Accumulation in Asynchronously Growing Sarcoma 180 Cells, by Ham Mujagic, Shan-Shan Chen, Richard Geist, Sandra J. Occhipinti, Bruce M. Conger, Charles A. Smith, William H. Schuette and Stanley E. Shackney. Schedule Dependence of Vincristine Lethality in Sarcoma 180 Cells following Partial Synchronization with Hydroxyurea, by H a m Mu- jagic, Bruce M. Conger, Charles A. Smith, Sandra J. Occhipinti, William H. Schuette and Stanley E. Shackney. Immunochemical Study on the Contributions of Two Molecular Species of Microsomal Cytochrome P-450 to the Metabolism of Ben- m(a)pyrene by Rat Liver Microsomes, by Eiichi Hara, Kaname Kawajiri and Yusaku Tagashira. Quenching of DNA:Platinum(II) Monoadducts as a Possible Mechan- ism of Resistance to cis-Diamminedichloroplatinum(I1) in L1210 Cells, bv Kenneth Micetich. Leonard A. Zwellina and Kurt W. Kohn.

Effect of Pyran Copolymer on Activation of Murine Macrophages: Evidence for Incomplete Activation by Use of Functional Markers, by Dolph 0. Adam, William J. Johnson, Philip A. Marino and Jack H. Dean. Presence of Specific Binding Sites for Phorbol Ester Tumor Prom- otors in Human Epidermal and Dermal Cells in Culture but Lack of Down Regulation in Epidermal Cells, by Kazuhiro Chida and Toshio Kuroki. Genetic Differences in Metabolism of Benzo(a)pyrene in Cultured Epidermal and Dermal Cells of Responsive and Nonresponsive Mice, by Jiro Hosomi, Nobuo Nemoto and Toshio Kuroki. Energy Metabolism in Nongrowing Mice with Sarcoma, by Lars Lind- mark, Staffan Edstrom, Lars Ekman, Ingvar Karlberg and Kent Lundholm. Inhibition of Human Lymphoma DNA-dependent RNA Polymerase Activity by 6-Mercaptopurine Ribonucleoside Triphosphate, by Rus- sell T. Kawahata, Linda F. Chuang, Charles A. Holmberg, Bennie I. Osburn and Ronald Y. Chuang.

Cytochrome P-450-dependent Xenobiotic Metabolizing Activity in Zymbal’s Gland, a Specialized Sebaceous Gland of Rodents, by Roberta J. Pohl and James R. Fouts.

Genetic Control of Susceptibility of Rats to Gastric Carcinoma, by Hiroko Ohgaki, Takashi Kawachi, Nono Matsukura, Kazuhide Morino, Moriyoshi Miyamoto and Takashi Sugimura. Production of Growth-inhibitory Activity in Serum-free Medium by Human Monocytic Leukemia Cells, by Edwin V. Gaffney, Shiow- Chuan Tsai, Marie L. Dell’Aquila and Susan E. Lingenfelter. Effect of Dietary Protein Concentration of Yield of Mutagenic Metabolites from 1,2-Dimethylhydrazine in Mice, by Frank W. Kari, James B. Johnston, C. Richard Truex and Willard J. Visek.

Differential Response of an Ovarian-responsive Mouse Mammary Tumor to Androgenic and Estrogenic Agents, by Akio Matsuzawa and Yukiko Ikeda. Effect of the Preestrogen 4-Androstene-3,17-dion-19-a1 on the Dun- ning R3327 Prostatic Adenocarcinoma, by Thomas A. Marks and Vladimir Petrow. Inability of Cytoplasmic or Nuclear Androgen Receptor Content or Distribution to Distinguish Benign from Carcinomatous Human Pros- tate, by Sydney A. Shain, Lester S. Gorelic, Robert W. Klipper, Ibrahim Ramzy, Donald E. Novicki, Howard M. Radwin and Donald L. Lamm. Enhancement of Sensitivity to Adriamycin in Resistant P388 Leukemia by the Calmodulin Inhibitor Trifluoperazine, by Ram Ganapathi and Dale Grabowski. Likelihood of the New Antitumoral Drug 10- y-Diethylaminopropy- lamino]4-methyl-5H-pyrido[3’4,’ :4,5]-pyrrolof2,3-g]isoquinotine (BD-40), a Pyridopyrroloisequinoline Derivate, to Induce DNA Strand Breaks in Vivo and its Nonmutagenicity in Yeast, by E. Mous- tacchi, V. Favaudon and E. Bisagni. Role of Whole-Body Lipids and Nitrogen as Limiting Factors for Survival in Tumor-bearing Mice with Anorexia and Cachexia, by Elisabeth Eden, Lars Lindmark, Ingvar Karlberg and Kent Lund- holm. Dose-Response Relationship for the Binding of Benzo(a)pyrene Metabolites to DNA and Protein in Lung, Liver and Forestomach of Control and Butylated Hydroxyanisole-treated Mice, by Peter I. Ad- riaenssens, Catherine M. White and Marshall W. Anderson. Kinetics of N- and C-Hydroxylations of 2-Acetylaminofluorene in Male Sprague-Dawley Rat Liver Microsomes:Implications for Car- cinogenesis, by Michael E. McManus, Rodney F. Minchin, Nancy Sanderson, Peter J. Wirth and Snorri S. Thorgeirsson. Flow Cytometric and Morphological Studies of Ovarian Carcinoma Cell Lines and Xenografts, by Caroline van Haaften-Day, Peter Rus- sell, Cathy Rugg, Edward J. Wills and Martin H.N. Tattersall.

Rapid and Reversible Inhibition of junctional &-unication by Tumor Promoters in a Mouse Cell Line, by D. James Fitzgerald, Soencer E. Knowles. F. John Ballard and Andrew W. Murrav.

Inhibition Of Mouse Skin Tumor Promotion and of Promoter-stimu- lated Epidermal Polyamine Biosynthesis by a-Difluoromethylor- nithine, by Masaharu Takigawa, Ajit K. Verma, R.c. Simsiman and R.K. Boutwell.

Distribution Metabolism, and Excretion of 1-(2-Fluoro-2-deoxy-B-~- arabinofuradosy1)thymidine and 1-(2-Fluro-2-deoxy-B-o-arabino- Detection and Measurement of a-Fetoprotein in Human Breast furanosyl)-5-iodocytosine by Frederick S . Philip, Aaron Feinberg, Cancer ~ o s o l after Treatment with 0.4 M Potassium Chloride, by Ting-Chao Chou, pedrd M. Vida, ~ ~ ~ ~ ~ - b ~ ~ su, Kyoichi A, Edward J. Sarcione, Martin Zloty, Daniel S . Delluomo, Gerald Mize- Watanabe and Jack J. Fox. jewski and Herbert Jacobson. Enhanced Macromolecular Binding of N-[4-(5-Nitro-2-fury1)-2- Subcellular Distribution of Inorganic Pyrophosphatasc Activity in thiazolyl]formamide in Germfree versus Conventional Rats, by Ken- Various Normal and Neoplastic Cell Types, by Jennie B. Shatton, neth C. Morton and Ching Y. Wang. Albert Williams and Sidney Weinhouse.

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Enhanced Synthesis of a Specific Protein by 12-0-Tetradecanoylphor- bol-13-acetate in Cultured Chick Embryo Muscle Cells, by Bianca M. Zani and Mario Molinaro. Comparable Growth Regulation of Five Human Tumor Cell Lines by Neonatal Human Lung Fibroblasts in Semisolid Culture Media, by David Kirk, Susumu Kagawa and Gudrun Vener. cis-Diarnminedichloroplatinum(I1) Nephrotoxicity: Tubular Function after Rescue with Sodium Diethyldithiocarbamate in Rats, by W.C. Elliott, Samuel R. Newcom, Donald C. Houghton, Joan Baines- Hunter and W.M. Bennett. Characterization of a Calcitonin-responsive Cell Line Derived from a Human Osteosarcoma, by Gabriel Eilon, Janice Perkins and Michael V. Viola. Indirect Immunofluorescence Studies of Proliferating Cell Nuclear Antigen in Nucleoli of Human Tumor and Normal Tissues, by Pui- Kwong Chan, Rebecca Frakes, Eng M. Tan, Michael G. Brattain, Karel Smetana and Hams Busch. Characterization of Protein Phosphorylation of the Cytosol of AH46 Hepatoma Ascites Cells, by Kazuyasu Nakaya, Takashi Shimizu, Yoshihide Segawa, Shigeo Nakajo and Yasuharu Nakamura. Isoyme Phenotypes of Polyoma Virus Tumors in Mice, by Suzanne Eileen Fisher, Clyde Johnson Dawe, Jeanette Earle Williams and Willie DeWard Morgan. A New Bioactive Form of Human Calcitonin, by Paul H. Tobler, Maximilian A. Dambacher, Walter Born, Philipp U. Heitz, Rend Maier and Jan A. Fischer. Regional [ ''C]Misonidazole Distribution in Experimental RT-9 Brain Tumors, by Marc Horowitz, Ronald Blasberg, Peter Molnar, John Strong, Paul Kornblith, Roger Pleasants and Joseph Fenstermacher. Shedding and Immunoregulatory Activity of YAC-1 Lymphoma Cell Gangliosides, by Stephan Ladisch, Baiba Gillard, Clifford Wong and Lisa Ulsh. Aneuploidy Induction and Cell Transformation by Diethylstilbestrol: A Possible Chromosomal Mechanism in Carcinogenesis, by Takeki Tsutsui, Heiji Maizumi, John A. McLachlan and J. Carl Barrett. Reconfirmation of Indirect Induction of Radiogenic Lymphomas Us- ing Thymectomized, Irradiated B10 Mice Grafted with Neonatal Thy- muses from Thy 1 Congenic Donors, by Masahiro Muto, Toshihiko Sado, Isamu Hayata, Fumio Nagasawa, Hitoko Kamisaku and Eiko Kubo. Characterization of Two Metastatic Subpopulations Originating from a Single Human Colon Carcinoma, by Ellen N. Spremulli, Caron Scott, Debora E. Campbell, N. Peter Libbey, Dan Shochat, David V. Gold and Daniel L. Dexter. Dimorphism of Sister Chromatid Exchange in Bloom's Syndrome B- and T-cell Lines Transformed with Epstein-Barr and Adult T-cell Leukemia Viruses, by Yukimasa Shiraishi, Shizuo Yoshimoto, Isao Miyoshi, Naomi Kondo, Tadao Orii and Avery A. Sandberg. Glycoprotein Exhibiting Immunological and Enzymatic Activities of Human Prostatic Acid Phosphatase, by Ming-Fong Lin, Ching-li Lee, Farida S. Sharief, Steven S-L. Li and T. Ming Chu. Glucocorticoid Receptor Levels in Mouse Skin after Repetitive Ap- plications of 12-0-Tetradecanoylphorbol-13-acetate and Mezerein, by Kowetha A. Davidson and Thomas J. Slaga. Unilateral Chromatid Damage: A New Basis for 6-Thioguanine Cy- totoxicity, by Jonathan Maybaum and H. George Mandel. Monoclonal Antibodies to Carcinoembryonic Antigen: Ionic Strength as a Factor in the Selection of Antibodies for Immunoscintigraphy , by Charles M. Haskell, Franz Buchegger, Magali Schreyer, Stefan Car- rel and Jean-Pierre Mach. Glucocorticoid-resistant Human Acute Lymphoblastic Leukemic Cell Line with Functional Receptor, by Robert Zawydiwski, Jeffrey M. Harmon and E. Brad Thompson. Characterization of a Family of Glycoproteins Associated with the Bile Canalicular Membrane of Normal Hepatocytes but Not Expre-

ssed by Two Transplantable Rat Hepatocellular Carcinomas, by Douglas C. Hixson, James P. Allison, Judith E. Chesner, Marilyn I. Leger, Linda L. Ridge and Earl F. Walborg Jr. Immunohistilogical Study of Precancerous Mucus Modification in Hu- man Distal Colonic Polyps, by J. Bara, 0. Languille, M.C. Gendron, N. Daher, E. Martin and P. Burtin. Association of the Human Type C Retrovirus with a Subset of Adult T-cell Cancers, by Robert C. Gallo, V.S. Kalyanaraman, M.G. Sam- gadharan, Ann Sliski, Eric C. Vonderheid, M. Maeda, Yoshinobu Nakao, Kazumasa Yamada, Yohei Ito, Nancy Gutensohn, Sharon Murphy, Paul A. Bum, Jr., Daniel Catovsky, M.F. Greaves, Doug- las W. Blayney, William Blattner, W.F.H. Jarrett, Harald zur Hausen, M. Seligmann, J.C. Brouet, Barton F. Haynes, Brian V. Jegasothy, Elaine Jaffe, Jeffrey Cossman, Samuel Broder, Richard I. Fisher, David W. Golde and Marjorie Robert-Guroff. Epidemiology of Coffee and Pancreatic Cancer, by E.L. Wynder, N.E.L. Hall and M. Polansky. Phase I Evaluation and Pharmacokinetics of Aziridinylbenzoquinone Using a Weekly Intravenous Schedule, by Rudolf B. Schilcher, John D. Young, Lawrence P. Leichman, Charles D. Haas and Laurence H. Baker. Transcription of Hematopoietic-associated Oncogenes in Childhood Leukemia, by Dan Rosson and Allan Tereba. Mitoxantrone in Patients with Acute Leukemia in Relapse, by Paolo Albert0 Paciucci, Takao Ohnuma, Janet Cuttner, Richard T. Silver and James F. Holland. Deficiency in Epstein-Barr Virus Receptors on B-Lymphocytes of Preleukemia Patients, by David J. Volsky and Ronald W. Anderson. Effects of S-Phase-specific Agents on Granulocyte-Macrophage and Erythroid Progenitor Cells Obtained from Normal Individuals and from Patients with Chronic Myelogenous Leukemia, by Kazuo Kubo- ta, Harvey D. Preisler and Catherine Costanzo. Production and Molecular Size Heterogeneity of Immunoreactive Gastrin-releasing Peptide in Fetal and Adult Lungs and Primary Lung Tumors, by Ken Yamaguchi, Kaoru Abe, Toru Kameya, Isamu Adachi, Sanae Taguchi, Kotomi Otsubo and Noboru Yanaihara. Plasma Levels of Estrone, Estrone Sulfate, and Estradiol and the Percentage of Unbound Estradiol in Postmenopausal Women with and without Breast Disease, by M.J. Reed, R.W. Cheng, C.T. Noel, H.A.F. Dudley and V.H.T. James. Occurrence of Fibrin and Tissue Factor Antigen in Human Small Cell Carcinoma of the Lung, by Leo R. Zacharski, Alan R. Schned and George D. Sorenson. Tamoxifen-induced Fluorescence as a Marker of Human Breast Tumor Cell Responsiveness to Hormonal Manipulations: Correlation with Progresterone Receptor Content and Ultrastructural Altera- tions, by Jacqueline Mouriquand, Michble Jacrot, Josette Louis, Marie-Ange Mermet, Simone Saez, Jean-Clement Sage and Claude Mouriquand. High-Affinity Erythrocyte Rosette Formation and Inhibition in Pre- malignant Disease of the Uterine Cervix, by John Bashford and Ian R. Gough. Depression of High-Affinity Rosette Formation in Dysplasia and Car- cinoma in Siru of the Uterine Cervix: Mediation by Serum Factors, by John Bashford and Ian R. Gough. Circadian Rhythmicity of Polyamine Urinary Excretion, by William J.M. Hrushesky, James Merdink and Mahmoud M. Abdel-Monem. Letter to the Editor The Governance of Science at the National Cancer Institute: A Pers- pective on Misperceptions, by Vincent T. DeVita, Jr. Meeting Report Multidisciplinary Approach to Management of Patients with Mesothelioma, by Nikolay V. Dimitrov, Samuel M. McMahon and David T. Carr.

BRITISH JOURNAL OF CANCER - VOL. 48, NO. 3, SEPTEMBER 1983 Editorial Office: Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX, England

Treatment of advanced malignant melanoma with high-dose melpha- lan and autologous bone marrow transplantation, by M.A. Cornbleet, T.J. McElwain, P.J. Kumar, J. Filshie, P. Selby, R.L. Carter, D.W. Hedley, M.L. Clark and J.L. Millar.

Problems of interpretation of serum concentrations of alpha-foetop- rotein (Am) in patients receiving cytotoxic chemotherapy for malig- nant germ cell tumours, by S. Coppack, E.S. Newlands, J. Dent, H. Mitchell, G. Goka and K.D. Bagshawe.

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Multivariate analyses as aids to diagnosis and assessment of prognosis in gastrointestinal cancer, by J. de Mello, L. Struthers, R. Turner, E.H. Cooper, G.R. Giles, and The Yorkshire Regional Gastrointesti- nal Cancer Research Group. Trends in mortality from carcinoma of the liver and the use of oral contraceptives, by D. Forman, R. Doll and R. Peto. A proportionate study of cancer mortality among members of a veg- etarian society, by L.J. Kinlen, C. Hermon and P.G. Smith.

Malignant ovarian turnours in childhood in Britain, 1962-78, by C. La Vecchia, H.B. Morris and G.J. Draper. The effect of radiosensitizers on the pharmacokinetics of methphalan and cyclophosphamide in the mouse, by M. Hinchliffe, N.J. McNally and M.R.L. Stratford. Advantage of reduced oxygen tension in growth of human melanomas in semi-solid cultures: Quantitative analysis, by R.M. Joyce and P.C. Vincent. Role of “lymphotoxin” in the local antitumour action associated with inflammation caused by delayed hypersensitivity responses or intrale- sional BCG. Part 1. Variations in response of different syngeneic mouse tumours, by I.B. Parr L.E. Jackson and P. Alexander.

Anti-tumour cytotoxin produced by human monocytes: Studies on its mode of action, by N. Matthews. Antibody production in cultured blood lymphocytes from breast cancer patients, by M.L. Villa, M. Migliori and E. Clerici. Effect of clofibrate on the growth-kinetics of the murine P 1798(sc) lymphoma, by F.M. Ubeira, R. Seoane, E. Puentes, J. Faro and B.J. Regueiro. The sex hormone profile of male patients with breast cancer, by D. Nirmul, R.J. Pegoraro, I. Jialal, C. Naidoo and S.M. Joubert. The carcinogenic potential of twelve refined mineral oils following longterm topical application, by S.M.A. Doak, V.K.H. Brown, P.F. Hunt, J.D. Smith and F.J.C. Roe. Hepatocellular carcinoma and oral contraceptives, by B.E. Hender- son, S. Preston-Martin, H.A. Edmondson, R.L. Peters and M.C. Pike. The role of natural killer cells in the intravascular death of intraven- ously injected murine tumour cells, by C.J. Bishop and V.A. Whiting. Failure of high doses of a interferon to affect the growth of human carcinoma, melanoma and myeloid leukaemia xenografts, by R.D. Clutterbuck, J.L. Millar and P. Alexander.

BULLETIN DU CANCER - VOL. 70, NO. 3, 1983 (Articles in English or French - Abstracts in English)

Editorial Office: Fondation Curie, Section medicale, 26 rue d’Ulm, 75231 Paris Cedex 05, France

Cancers, Oncogenesis and Oncogens, by G. Meyer and J. Nicoli (In French). Inflammatory breast cancers: histological features and steroid recep- tors determination, by L. Mauriac, J. Wafflart, M. Trojani and M. Durand (In French).

Immunotoxins, by F.K. Jansen, H.E. Blythman, D. Caribre, P. Casellas, D. Dussossoy, 0. Gros, P. Gros, J.C. Laurent , F. Paolucci, B. Pau, P. Poncelet, G. Richet, H. Vidal and G.-A. Voisin (In French).

Pharmacokinetic study of GI track tumor specific monoclonal anti- bodies in tumor bearing nude mice, by J.Y. Douillard, J.F. Chatal and J.C. Saccavini (In French).

Immunohistochimical study of GI track tumor with specific mono- clonal antibodies, by M. Kremer, C. Curtet, J.Y. Douillard and J.F. Chatal (In French).

Serum ferritin measurement in the evaluation of loco-regional exten- sion of gastric carcinoma, by M.A. Gioffre Florio, A. Venuti, G. Caputo, M. La Rosa, G. Giorgianni and B. Micali (In French). Forum 1983 of Oncology: Abstracts on fundamental and clinical on-

Seric pregnancy-specific beta 1 glycoprotein in breast cancer, by A. Ruibal, G. Encabo, R. Gefaell, D. Pons, A. Lafuerza and F.M. Domenech-Torn6 (In English). Serum pepsinogen I as an index of gastric cancer, by M. Sianesi, E. Palummeri, D. Prowedini, S. Scuto and E. Molina (In French). Histologic classification of cola-rectal cancer related to spread, by M. Prade, C. Bognel, P. Duvillard and P. Charpentier (In French). IVth Symposium of Clinical Cancer Biochemistry, by P. Cambon (Nice, December 8-9, 1983) (In French). Meeting of the Anesthesiology Departments of French Cancer Cen- ters: abstracts (In French).

cology.

ARCHIV FUR GESCHWULSTFORSCHUNG - VOL. 53, No. 4,1983 Editorial Office: Central Institute of Cancer Research, Academy of Sciences, GDR, Lindenberger Weg 80, 1115 Berlin-Buch, GDR

Retroviruses in human tumors, by R. Kurth, J. E w e r , R. E w e r , K. Boller and H. Frank. The genetics of transformation by SV 40, by J. Feunteun and C.A. Petit. The possible etiological role of retroviruses in human tumors, by D. Bienvolf. Widespread occurrence in mammals of antibodies reactive to intracy- toplasmic A particles of the mouse mammary tumor virus, by St. Zotter. Antibodies presumably cross-reacting with mouse retrovirus type B and C in the sera of both leukemia-lymphoma and mammary cancer patients, by A. Segal-Eiras, M.V. Croce and Chr.D. Pasqualini. The carcinogenicity of I-rnethyl-3(p-bromophenyl)-I-nitrosourea (Br- MPNU), by R. Warzok, J. Martin, J. Mendel, R. Trust and H. Schwarz. Enhancement of hyperthermia bodies lethality by Lanthanum, by L.J. Anghileri, C. Marchal, M.C. Crone and J. Robert.

Parietal cell antibodies and gastric cancer, by P. Reitzig, E. Apos- toloff, G.-P. Wildner, H.-J. Giitz and F. Irro. Diagnostic value of extracranial wholebody computerized tomogra- phy for tumorous disease in childhood, by E. Kriedemann, K.-H. Rotte, H. Marciniak and F.-H. Redlich. Malignant testis tumors in monozygote twin brothers, by B. Klein- teich and G. Marx. Lung cancer in Berlin, capital of the GDR, from 1975 to 1979, by E. Kluge, K. Ebeling and P. Nischan. Ethnic differences in cancer frequency, by J.F. Haas. 13th International Cancer Congress, SeattleAJSA, September 8-15, 1982, by St. Tanneberger, G. Marx and K. Ebeling. 5. Symposium Orofasziale Onkochirurgie, Bmo/&SR, 19.9.- 1.10.1982. “The action of 4-hydroxyanisole and other phenolic antioxidants”, Melanoma Discussion Group Meeting, London, September 27,1982.

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BOHPOCbI OHKOJIOTMR, VOPROSY ONKOLOGII - Vol. 24, No. 5 , SEPTEMBER 1982

Editorial Office: N.N. Petrov Research Institute of Oncology, 68 Leningradskaya St., Pesochny-2, Leningrad 188646, USSR (Articles in Russian - Abstracts in English)

Development of cancer research in dissertations defended within 1976-1980, by N.N. Trapemikov, N.M. Barmina, A.A. Klimenkov, R.M. Strelkova, A.B. Syrkin and V.S. Turusov. Patent studies in planning and carrying out research, by Ye.V. Kapat- sinsky, G.I. Rosenbaum, T.S. Matrosova, T.S. Lebedkovay and I.V. Loginova. Diagnostic laparotomy with splenectomy in pediatric Hodgkin's dis- ease, by L.A. Makhonova, L.A. Durnov, V.Ye. Polyakov, B.A. Kolygin, I.V. Koshel, B.Ya. Vyalushkin, L.A. Romantsova, V.N. Lebedev and N.N. Pokrovskaya. Suppression of endocrine function of thymus and changes in lympho- cyte, plasmic membrane properties during chemotherapy of children with systemic malignant diesease, by Yu.A. Grinevich, I.S. Nikolsky, L.A. Titorenko and N.G. Kononenko.

Terms of local recurrence development and long-term results of treat- ment of skin melanoma following excision of primary tumor, by V.V. Anisimov. Clinical course and effectiveness of treatment of minimal breast cancer, by V.F. Semiglazov and A.A. Orlov.

Combined treatment of carcinoma of the mid-third of the esophagus, by A.A. Rusanov, M.G. Bushilov, V.G. Gherasimyak and A.V. Gubareva. Correction of pituitary-adrenal function in patients with esophageal and gastric cancer who receive combined and surgical treatment, by V.I. Tarutinov, V.B. Vinnitsky, V.L. Ganul and O.Ye. Pridatko. Anatomy and topography of regional lymph nodes of liver and gall- bladder, by M.R. Sapin and A.K. Usovich.

The study on the degree of rectal cancer cell differentiation by light and electron microscopy, by A.G. Perevoshikov, N.T. Raikhlin and

Influence of schedule of treatment and route of administration on the carcinogenicity of 1,2-dimethylhydrazine in mice, by V.S. Turusov, N.S. Lanko, A.N. Murovanny, L.S. Bazlova and A.F. Karamysheva. Microroentgenography of transplantable tumors, by I.S. Amosov, N.A. Sazonova and T.G. Morozova.

J D. Katenkamp. 1

Chronic lympholeucosis in cattle as an experimental model in search of oncogen, by R.A. Kukain, L.I. Nagayeva and V.P. Lozha.

On oncogene once more, by V.S. Shapot, M.A. Shlyankevich and V.V. Lobanenkov. Oncofactors (transforming growth factors), by A.G. Golubev and V.M. Dilman.

Merland J . J . , Chires J., Arteriography of the Pelvis: Diagnostic and Therapeutic Procedures. - Berlin etc.: Springer-Verlag, 1981, by A.G. Vesnin. Klinische Onkologie: Leitfaden f i r Studenten und k t e , Hersg. un- ter der Aufsicht u. Mitwirkung der UICC. - Berlin: Akademic-Ver- lag, 1982, by L.Yu. Dymarsky. IARC Monographs on the Evaluation of the Risk of Chemicals to Humans. Vol. 29. Some Industrial Chemicals and Deystuffs. - Lyon, 1982, by V.V. Khudoley.

Logan W.P.D. Cancer Mortality by Occupation and Social Class 1851-1971. -London; Lyon, 1982 (IARC Sci. Publ. No. 36.). byV.M. Merabishvili.

Leukaemial Ed by N.L. Warner, D. Metcalf. - Geneva, 1981. - (UICC Techn. Rep. Ser. Vol. 61), by M.L. Ghershanovich.

Inhibition of Tumor Induction and Development/ Ed. by M.S. Zedeck, M. Lipkin. - New York; London; Plenum Press, 1981, by E.A. Ratovitsky. Resolution of the 9th Transcaucasian Conference of Oncologists. Joint Scientific-Practical Conference of the P.A. Herzen Research Institution of Oncology of the RSFSR Ministry of Health, Moscow City Oncological Dispensary and Municipal Oncological Hospital No. 62, by V.I. Chissov and R. Slesareva. Proceeding of the 295th meeting of the Scientific Society of Oncolog- ists of Moscow and Moscow Region.

Proceedings of the 275th and 276th meetings of the Scientific Society of Oncologists of Leningrad and Leningrad Region. Khonelidze (60th birthday), by B. Gibi.

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY - Vol. 19, NO. 9, SEPTEMBER 1983 Editorial Office: Institut Jules Bordet, Centre des Tumeurs de l'Universit.6 Libre de Bruxelles, 1 rue H.6ger-Bordet, Brussels, Belgium

Whole-body hyperthermia in cancer therapy: a report of a phase 1-11 study, by J. van der Zee, G.C. van Rhoon, J.L. Wike-Hooley, N.S. Faithfull and H.S. Reinhold.

The effects of a novel potent oral retinoid (Ro13-6298) in the treat- ment of multiple solar keratoses and squamous cell epithelioma, by T. Kingston, S. Gaskell and R. Marks.

DNNprotein ratio as an index of oestrogen receptor content in hu- man breast cancer, by J. Muiroz, P. Bolufer, A. Rodriguez, P. An- tonio and C. Vazquez.

Thyroid function in early breast cancer, by B.S. Thomas, R.D. Bul- brook, M.J. Russell, J.L. Hayward and R. Millis.

Standardization of steroid receptor assays in human breast cancer-I. Reproducibility of estradiol and progesterone receptor assays, by A. Koenders and S.M. Thorpe.

Effects of 5-fluorouracil and 2a-methyl-dihydrotestosterone propion- ate on the growth of human breast carcinoma MCF-7 in vitro, by H. Fujita, M.N. Teller, S. Green and W. Kreis. Monoclonal antibodies to different epitopes of human alpa-fetopro- tein (AFP), by B. Micheel, H. Fiebach, U. Karsten, A.I. Goussev, A.K. Jazova and J. Kopp. The effects of membrane modification and hyperthermia on the survi- val of P-388 and V-79 cell, by M.B. Yatvin, J.w. Vorpahl, M.N. Gould and M. Lyte. Sera from irradiated rats contain antibodies to a ubiquitous tumour- associated antigen, by P. Bentvelzen, M.A. Dubbeld, W.H. Koornst- ra, J.J. Broerse and M.J. van Zwieten. VIIth Meeting of the European Association for Cancer Research. Second International Conference on Malignant Lymphoma, Lugano, Switzerland, 13-16 June 1984. Books Received, Announcement Abstracts.

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