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ANOVA WT dZAP1 p < 0.05 2378/6189 (31.42%) 2264/6189 (36.58%) p < 0.01 1527/6189 (24.67%) 1445/6189 (23.35%) p < 0.001 860/6189 (13.90%) 792/6189 (12.80%) p < 0.0001 460/6189 (7.43%) 414/6189 (6.69%) B-H p < 0.05 1656/6189 (26.76%) 1538/6189 (24.85%) Bonferroni p < 0.05 228/6189 (3.68%) 192/6189 (3.10%) Table 1: Bonferroni-adjusted p-value proved most selective with 3.68% while, as expected, the other data became more specific as the p-value became more stringent Percentages of specific p-value data

ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

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Page 1: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

 ANOVA WT dZAP1

p < 0.05 2378/6189 (31.42%) 2264/6189 (36.58%)

p < 0.01 1527/6189 (24.67%) 1445/6189 (23.35%)

p < 0.001 860/6189 (13.90%) 792/6189 (12.80%)

p < 0.0001 460/6189 (7.43%) 414/6189 (6.69%)

B-H p < 0.05 1656/6189 (26.76%) 1538/6189 (24.85%)

Bonferroni p < 0.05 228/6189 (3.68%) 192/6189 (3.10%)

Table 1: Bonferroni-adjusted p-value proved most selective with 3.68% while, as expected, the other data became more specific as the p-value became more stringent

Percentages of specific p-value data

Page 2: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Overall STEM Profile Results for Wild Type

Page 3: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Profile 45 Results

Page 4: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Profile 22 Results

Page 5: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Profile 9 Results

Page 6: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Profile 28 Results

Page 7: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Profile 48 Results

Page 8: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Profile 0 Results

Page 9: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

DNA Binding And Expression Degree Distribution

1 20

0.5

1

1.5

2

2.5

3

3.5

Degree Distribution

Series1 Series2

Degree

Num

ber o

f Nod

es

Page 10: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

DNA Binding Plus Expression Degree Distribution

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 220

1

2

3

4

5

6

7

Degree Distribution

In-degree total Out-degree total

Degree

Num

ber o

f Nod

es

Page 11: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Only DNA Binding Degree Distribution

1 2 3 4 5 6 7 80

1

2

3

4

5

6

7

8

9

10

Degree Distribution

In-degree total Out-degree total

Degree

Num

ber o

f Nod

es

Page 12: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Gene regulatory network for matrix of binding AND expression (5 edges)

Page 13: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Gene regulatory network for documented binding PLUS expression (141 edges)

Page 14: ANOVA WTdZAP1 p < 0.052378/6189 (31.42%)2264/6189 (36.58%) p < 0.011527/6189 (24.67%)1445/6189 (23.35%) p < 0.001860/6189 (13.90%)792/6189 (12.80%) p

Gene regulatory network for DNA binding ONLY (35 edges)