I. 8.0*. 8.�dhide�. M.14p.... i..d Oil., S.c..Wy H�des 0e.w�g e I

s#{149}cl_.#{149}ssWI4.�, . C#{149}I�,g I P#{149},c*�I w Me� 04 To� A�e�nI .1 Io�ds. Mo’Iq�.s C OthS(

PS P... 3526. i=.y 1991 42., M*� �

1992 mAChRs in SH-SY5Y and IMR-32 1493

receptors to hydrolysis of inositol lipids in human neuroblastoma SH-SY5Ycells. Brain Res. 504: 7-14, 1989.

PERALTA, E. G., ASHKENAZI, A., WINsLow, J. W., RAMACHANDRAN, J. AND

CAPON, D. J.: Differential regulation of P1 hydrolysis and adenylyl cyclase bymuscarinic receptor subtypes. Nature 334: 434-437, 1988.

PINKAS-KRAMARSKI, R., EDELMAN, R. AND STEIN, R.: Indications for selective

coupling to phosphoinositide hydrolysis or to adenylate cyclase inhibition byendogenous muscarinic receptor subtypes M3 and M4 but not by M2 in tumor

cell lines. Neurosci. Lett. 108: 335-340, 1990.SAIKI, R. K., ScHARF, S., FALOONA, F., MuLLI5, K. B., HORN, G. T., ERLIcH,

H. A. AND ARNHEIM, N.: Enzymatic amplification of beta-globulin genomicsequences and restriction site analysis for diagnosis of sickle cell anemia.Science 230: 1350-1354, 1985.

SANGER, F., NICKLEN, S. AND CouLsoN, A. R.: DNA sequencing with chaintermination inhibitors. Proc. Natl. Acad. Sci. USA 74: 5463-5467, 1977.

Scorr, I. G., AKERMAN, K. E. 0., HEIKKILA, J. E., KAILA, K. AND ANDERSON,

L. C.: Development of a neuronal phenotype of in differentiating ganglion cell-derived human neuroblastoma cells. J. Cell. Physiol. 128: 285-292, 1986.

SERRA, M., LIN, M., ROESKE, W. R., LUI, G. K., WATSON, M. AND YAMAMURA,H. I.: The intact human neuroblastoma cell (SH-SY5Y) exhibits high-affinity

l3Hlpirenzepine binding associated with hydrolysis of phosphatidylinositols.J. Neurochem. 50(5): 1513-1521, 1988.

TSUN00, A. AND NARAHASHI, T.: Cyclic nucleotide potentiation of muscarinic

responses in neuroblastoma cells. Brain. Res. 407: 55-67, 1987.TUMIL0wIcz, J. J., NIcHoLs, W. W., CHOLAN, J. J. AND GREEN, A. E.: Definition

of a continuous human cell line derived from neuroblastoma. Cancer Res. 30:2110-2118, 1970.

Send reprint requests to: Jyrki Kukkonen, Department of Biochemistry andPharmacy, Abo Akademi University, Biocity, P.O. Box 66, SF.20521 Turku,Finland.

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1494

INDEX

Volume 263, October-December, 1992

A23178, -dependent chloride secretion, an-tiflammins, distal colonic mucosa

(rabbits), 579Aagaard, P. J., see Miller, J. H., 663Abecarnil, pharmacology of r-aminobutyric

acidA receptor complex (rats), 1360

Abel, P. W., see Porter, J. E., 1062

Aberg, G., see Ogletree, M. L., 374

Abram, T. S., see Labat, C., 800

Acetylcholineinduced release, ileum longitudinal mus-

cle-myenteric plexus, anatoxin-a(guinea pigs), 997

inhibition of smooth muscle contraction,

M3 muscarinic receptor antagonists(rabbits), 773

nicotinic receptor-evoked release, myen-

teric plexus (guinea pigs), 1

NMDA receptor antagonists and scopol-amine, intrahippocampal injections,working and reference memory(rats), 943

oxidant-evoked release, enteric neuronsof colon (rats), 1068

pharmacological characterization of PD118717 (mice), 1147

Acinar cells, parotid gland, atypical alpha-iadrenergic receptors (rats), 1062

Acker, G. M., see Devillier, P., 767Action potential, membrane electrical activ-

ity, detrusor muscle, pinacidil (guinea

pigs), 816

Adams, M. L., see Little, P. J., 1056

Adenosineantinociception, spinal or supraspinal re-

ceptor-selective opioid agonists(mice), 1097

A1 receptor interactions in vivo, experi-mental paradigm, 657

glycine-induced glomerular hyperfiltra-tion (rats), 1188

novel receptor in brain, labeling by [‘H]-

phenylaminoadenosine, 552

Adenosine triphosphateextracellular, phosphoinositide hydroly-

sis, glioma C6 cells (rats), 1248

induction of exocytosis by pardaxin, bo-

vine adrenal medullary chromaffincells, 1317

Adenylate cyclase-coupled opioid receptor complex, opioid

receptor antagonists (rats), 20

dopamine receptor subtype, brown adi-pose tissue, thermogenesis (rats), 823

forskolin-stimulated, inhibition by neu-ropeptide Y, bovine adrenal chromaf-fin cells, 1479

inhibition in locus coeruleus, mediation

of hypnotic response, alpha, agonist

(rats), 1046

isoproterenol-stimulated cyclic AMP ac-cumulation, M2 muscarinic recep-tors, intestinal smooth muscle (rats),221

muscarinic receptor-G protein coupling,

heparin, dextran and trypan blue(rats), 910

prejunctional muscarinic receptors, deepmuscular plexus, ileum (dogs), 226

Adenylyl cyclase

glucose transporter and, discrimination,[‘�I]-labeled forskolin analogs (rats),

1415

6-OHDA-induced lesions, regional ef-fects, dopamine Dl receptors (rats),

1454

Adipocytes, SL 84.0418, alpha-2 adrenocep-tor antagonist, pharmacological pro-file, 1327

Adipose tissue, brown, dopamine receptorsubtype, thermogenesis (rats), 823

Adrenalchromaffin cells

neuropeptide Y inhibition, forskolin-stimulated adenylate cyclase, 1479

prolonged stimulation, arachidonic acidand prostaglandin E2 (cattle), 527

glomerulosa cells, pharmacological pro-

file, HS-142-1 (cattle), 241

Adrenal medullabovine chromaffin cells, induction of ex-

ocytosis, pardaxin, 1317

cooperative modulation of voltage-de-

pendent sodium channels, brevetoxinand classical neurotoxins, 1347

Adrenoceptors

alphaangiotensin Il-induced vasopressin re-

lease, paraventricular nucleus (rats),

1253

hyperinsulinemia, indomethacin-in-duced antral ulcers (hamsters, rats),951

intrathecal St-587, nociceptive reflexes

and blood pressure (rats), 428alpha-i

parotid gland acinar cells (rats), 1062radioligand YM617 (rats), 201

alpha-2antagonist SL 84.0418, pharmacologi-

cal profile, 1327

hemodynamic and sedative effects, dex-medetomidine (dogs), 690

naloxone-induced bradycardia, periph-eral nervous system (rats), 918

norepinephrine and, active ion trans-port in small intestine (pigs), 510

alpha-2C and alpha-lA, prostaglandin

synthesis, signal transduction mech-

anisms (rabbits), 987beta

agonists, common carotid arteries (rab-

bits), 457

carvedilol, antioxidant and free radicalscavenger (rats), 92

cyclic AMP, muscarinic receptors

(rats), 221

stimulation in monocyte cell line, phos-

phodiesterase activity, 1195

beta-3, agonists BRL 37344 and CGP

12177, positive chronotropic effect

(dogs), 1083

cardiac and vascular responses to cocaine

(rats), 742

initiating of vomiting, gastrointestinal

motor correlates (dogs), 395

Adrenocorticotropic hormone, acute effectsof cocaine, cocaine-dependent men,

505

Adrenocorticotropin, melanocyte-stimulat-

ing hormone-like peptides, inhibitoryeffect, binding of dopamine receptorligands (rats), 787

Adriamycin, prevention of toxicity by

ethanol, liver (rats), 651Advenier, C., see Devillier, P., 767AF-DX 116

inhibition of pilocarpine responses, mus-

carinic receptor subtype antagonists

(monkeys), 1133muscarinic cholinergic receptor binding,

quantitative autoradiography, brain

(rats), 1391

Aging

effects of alcohol, hypothalamic-pitui-tary-gonadal axis, development

(rats), 1056

glutathione transport, blood-brain barrier(rats), 964

Ahmad, S., see Kostka, P., 226

Ahr#{233}n,B., see Karlsson, S., 494Airway, relaxation of trachea, release of

prostaglandin E2, neurokinin NK-1

. receptor (rats), 767

Akerman, K. E. 0., see Kukkonen, J., 1487Albrightson, C. R., Nambi, P., Zabko-Pota-

povich, B., Dytko, G., and Groom, T.:Effect of thrombin on proliferation,contraction and prostaglandin pro-duction of rat glomerular mesangial

cells in culture, 404

Albuquerque, E. X., see Ujihara, H., 859, 868

Alcoholacute administration, binding of Ro 15-

1788, brain (mice), 639

chronic ethanol treatment and pentobar-

bital, development of cross-tolerance

(mice), 480hypothalamic-pituitary-gonadal axis, de-

velopment (rats), 1056

influences of sedative-hypnotic drugs

(mice), 232

Aldose reductase, myo-inositol and, endo-

thelial cell dysfunction, elevated glu-

cose (rabbits), 153

Aldosterone, pharmacological profile of HS-142-1 (cattle), 241

Al-Kharouf, J. A., see Berger, M. E., 78Alper, G., see Bloor, B. C., 690

Aluminum, antacid and gastric mucosa in-teraction, “artificial stomach” model,1206

Alzheimer’s diseasebinding and functional selectivity, him-

1992 Index 1495

bacine, cloned and neuronal musca-rinic receptors, 663

memory impairment, passive avoidance

and radial arm tasks, effect ofFR121196 (rats), 436

Amantadine, memantine and, inhibitory ef-

fects, NMDA-evoked acetylcholinerelease in caudate nucleus (rabbits),717

Ambasilide, plateau currents, ventricularmyocytes (guinea pigs), 40

Amenta, F., Ferrante, F., Rossodivita, A.and Ricci, A.: Pharmacological char-

acterization and autoradiographic lo-calization of dopamine receptors inhuman epicardial arteries, 1447

Amiloride, -sensitive lithium reabsorption,

micropuncture (rats), 646Amines, cysteamine-related, somatostatin

depleting potency (rats), 752Amino acids

glycine-induced glomerular hyperfiltra-

tion, role of adenosine (rats), 1188renal and systemic effects, L-arginine and

non-nitric oxide donor aminoacids(rats), 1023

Aminoalkylindole, analogs, cannabimimeticactivity (mice, rats), 1118

-y-Aminobutyric acid, actions on GABAA re-

ceptors, general anesthetics, Xenopusoocytes, 569

Aminoglycoside, antibiotics and polyspartic

acid, determinants, in vitro interac-tion, 1464

Amperozide, carrier-mediated striatal do-pamine release (rats), 180

Amphetamine

brain dopamine systems, genetic mousemodel, Lesch-Nyhan syndrome, 596

effect of amperozide, carrier-mediatedstriatal dopamine release (rats), 180

3,4-methylenedioxymethamphetamine

and 5-HT,B, tolerance and cross-tol-erance (rats), 318

Amygdala, basolateral and central amygda-bid neurones, differential actions,

corticotropin releasing factor (rats),

846

Analgesiainteraction between intrathecal mu and

delta agonists, naltrindole and ben-zofuran analog (rats), 264

involvement of adenosine in antinocicep-

tion, spinal or supraspinal receptor-

selective agonists (mice), 1097

Analgesics, hemodynamic effects of GI870MB (dogs), 84

Anatoxin-a, induced acetylcholine release,ileum longitudinal muscle-myenteric

plexus (guinea pigs), 997

Andazola, J. J., Underwood, J. A., Chiono,M., Torres, 0. A. and Herman, C. A.:Leukotriene B4 and leukotriene B5have binding sites on lung mem-branes and cause contraction of bull-frog lung, 1111

Anesthesia

hemodynamic and sedative effects, dex-medetomidine (dogs), 690

hemodynamic effects ofGI 870MB (dogs),84

influences of sedative-hypnotic drugs

(mice), 232mediation of hypnotic response, inhibi-

tion of adenylate cyclase, alpha, ago-

nist (rats), 1046pentobarbital-enhanced flunitrazepam

binding, brain (rats), 1401

Anesthetics

general, -y-aminobutyric acid actions,Xenopus oocytes, 569

local properties, dopamine uptake block-

ade, cocaine and acetylcholine release(rats), 757

Angel, I., Schoemaker, H., Arbilla, S., Gal-

zin, A. M., Berry, C., Niddam, R.,Pimoule, C., Sevrin, M., Wick, A. andLanger, S. Z.: SL 84.0418: A novel,potent and selective alpha-2 adreno-

ceptor antagonist: In vitro pharma-cological profile, 1327

Angiotensin-converting enzyme inhibitors

captopril and diltiazem, glomerular hemo-

dynamics, clipped kidney (rats), 938enhanced blood pressure, renal hemody-

namic effect, lisinopril (rabbit), 158Angiotensin II

antagonists SK&F 108566 and EXP3174,

captopril and, renal function withrenal artery stenosis (dogs), 422

-induced vasopressin release, adrenergicand angiotensinergic receptors, par-aventricular nucleus (rats), 1253

receptor antagonist losartan, norepineph-

rine overflow and antidiuresis, stim-

ulation of renal nerves (dogs), 956renal hemodynamic response to blockade,

thromboxane A2 and prostaglandin

H, receptors (rats), 905

Annunziato, L., see Columbo, M., 979Anpirtoline, see D-16949Antacid, gastric mucosa and, interaction,

“artificial stomach” model, 1206Antiarrhythmic agents, RP 62719, positive

inotropic effects, myocardium

(guinea pigs), 1369

Antibiotics, aminoglycoside, polysparticacid and, determinants of in vitro

interaction, 1464Anticonvulsants

-induced hypersensitivity reactions, hu-man anti-cytochrome P450 antibod-ies, 360

U-5449A, block of voltage-gated potas-

sium currents, neuroblastoma cells

(mice), 207

Antidiuresis, norepinephrine overflow and,losartan, stimulation of renal nerves

(dogs), 956

Antiflammins, suppression of chloride se-cretion, A23187 and arachidonic acid,

distal colonic mucosa (rabbits), 579Anti-inflammatory drugs, gastroprotective

effects, thromboxane receptor antag-onists (rats), 374

Antinociceptionactions of spinal NSAIDS, formalin test

(rats), 136

adenosine, spinal or supraspinal receptor-

selective opioid agonists (mice), 1097induction of opposing effects on pain, L-

dopa (rats), 470

mechanisms of [D-Arg’]-dermorphin tn-peptide analogs (mice), 793

mu-mediated, modulation by opioid delta-2 receptors (mice), 147

Antioxidant, carvedilol (rats), 92

Antipsychotic agents

amperozide, carrier-mediated stniatal do-pamine release (rats), 180

clozapine, discriminative stimulus, 5-HT1� and 5-HT2 (pigeons), 276

DuP 734preclinical behavioral effects (mice),

1159receptor binding profile, brain (guinea

pigs), 1175Antisera, naloxone-insensitive receptor for

fl-endorphin, complementary peptidestrategy, U937 cells (rabbits), 876

Aorta, endothelial cell dysfunction, aldosereductase and myo-inositol, elevatedglucose (rabbits), 153

Apoptosis, dimethylnitrosamine-inducedhepatic necrosis, Ca’�-activatedDNA fragmentation (mice), 387

Appel, N. M., Robbins, J. D., De Souza, E.B. and Seamon, K. B.: [“'I]-Labeledfonskolin analogs whcih discriminate

adenylyl cyclase and a glucose trans-porter: Pharmacological character-

ization and localization of bindingsites in rat brain in vitro receptor

autoradiography, 1415

Arachidonic acid

competitive inhibitor ofgroup II phospho-lipase A2, YM-26567-i (rabbits), 1302

-dependent chloride secretion, antiflam-mins, distal colonic mucosa (rabbits),

579

prostaglandin E2 and, prolonged stimula-tion, adrenal chromaffin cells (cat-tle), 527

stimulation of release by platelet-activat-

ing factor, thromboxane B, produc-

tion, fetal brain (rats), 562Arbilla, S., see Angel, I., 1327

Arbilla, S, see Benavides, J., 884L-Arginine, renal and systemic effects, ami-

noacids (rats), 1023Arginine vasopressin

flavonoid potentiation, contractile re-

sponses, blood vessels (rats), 78

-induced cellular cAMP production, in-tracellular calcium pool, renal papil-lary collecting tubule cells (rats),1061

Anita, M., see Wada, A., 1347Arrang, J.-M., see Garbarg, M., 304Arrhythmia, conduction and sodium cur-

rent, rate-dependent effects, ethmo-

zine (dogs), 608Artery

analysis of interaction, lacidipine and

BAY K 8644 (rabbits), 1241common carotid, beta adrenoceptor ago-

nists (rabbits), 457contractile responses in blood vessels, fla-

vonoid potentiation (rats), 78coronary, smooth muscle, serotonin-in-

duced relaxation (dogs), 123

coronary and internal mammary, sero-tonin exposure, potency of L-calcium

channel inhibitors (humans), 112epicardial, autoradiognaphic localization,

dopamine receptors (humans), 1447large epicardial coronary, dilation, potas-

sium channel openers (dogs), 1091nonadrenergic and noncholinergic arte-

rial dilatation, venoconstriction, cal-citonin gene-related peptide (rats),1226

Arthus reaction, inhibition by NPC 15669,

1496 Index Vol. 263

block of neutrophil recruitment(rats), 933

Arunachalam, K. D., 428, see Loomis, C. W.Astrocytes, extracellular ATP-stimulated

phosphoinositide hydrolysis, gliomaC6 cells (rats), 1248

Atkinson, A. J., Jr., see Dordal, M. S.,762 Atrial natriuretic peptide,

pharmacological profile of HS-142-1(cattle), 241

Aulakh, C. S., Hill, J. L. and Murphy, D. L.:Effects of various serotonin receptor

subtype-selective antagonists alone

and on m-chlorophenylpiperazine-in-duced neuroendocrine changes inrats, 588

Autonomic nervous system, prejunctionalmuscaninic receptors, deep muscular

plexus, ileum (dogs), 226Autoradiography

cannabinoid binding site in brain (rats),1383

[“51]-labeled forskolin analogs, discrimi-nation, adenylyl cyclase and glucose

transporter (rats), 1415

localization of dopamine receptors, epi-cardial arteries (humans), 1447

muscarinic cholinergic receptor binding,brain (rats), 1391

pentobarbital-enhanced flunitrazepam

binding, brain (rats), 1401

Avidin, covalent conjugate, monoclonal an-tibody to transferrin receptor, biotindelivery to brain, 897

Baba, A., see Kitanaka, J.-I., 1248

Badr, M. Z.: Induction of peroxisomal en-

zyme activities by Di-(2-ethylhexyl)phthalate in thyroidectomized rats

with parathyroid replants, 1105Baghdoyan, H. A., see Carlson, B. X., 1401

Bahl, J. J., see Pennock, G. D., 163

Baicalein, flavonoid potentiation, contract-ile responses, blood vessels (rats), 78

Balster, R. L., see Compton, D. R., 1118

Baraban, J. M., see Bhat, R. V., 343Barbiturates, influences of sedative-hyp-

notic drugs (mice), 232Baroreflex

control of heart rate, heart failure after

myocardial infarction, captopnil(rats), 1424

positive chronotropic effect, BRL 37344

and CGP 12177 (dogs), 1083

Basophils, maitotoxin as activator of media-ton release, increases in cytosolic cal-

cium, histamine release, 979

Baton, J. M., see Bunch, R. M., 933BAY K 8644, lacidipine and, analysis of

interaction, arteries (rabbits), 1241

Beck, S. G., Choi, K. C., and List T. J.:Comparison of 5-hydroxytryptaminelA-mediated hy-

perpolanization in CAl and CA3 hip-pocampal pyramidal cells, 350

Behavior, passive avoidance and radial armtasks, memory impairment, effect of

FR121196 (rats), 436Benavides, J., Peny, B., Durand, A., Arbilla,

S. and Scatton, B.: Comparative in

vivo and in vitro regional selectivity

of central 0) (benzodiazepine) site li-gands in inhibiting [‘H)flumazenil

binding in the rat central nervous

system, 884Benzo(a)pynene, biotransformation and co-

valent binding, genetic deficiency,

bilirubin unidine diphosphate-glucu-

nonosyltransfenase (rats), 334

Benzodiazepinepentobarbital-enhanced flunitrazepam

binding, brain (rats), 14010) site ligands, inhibited flumazenil bind-

ing, central nervous system (rats),

884Benzofuran analog, naltnindole and, in-

trathecal mu and delta agonists

(rats), 264Berdeaux, A., see Dnieu la Rochelle, C., 1091Beregi, J.-P., Escande, D., Coudray, N.,

Mery, P., Mestre, M., Chemla, D. andLecarpentier, Y.: Positive inotnopic

effects of RP 62719, a new pure classIII antiarrhythmic agent, on guineapig myocardium, 1369

B#{233}r#{233}ziat,G., see Funck-Brentano, C., 780

Bergen, M. E., Golub, M. S., Chang, C.-T.,Al-Khanouf, J. A., Nyby, M. D., Honi,

M., Bnickman, A. S., and Tuck, M.L.: Flavonoid potentiation of con-tractile responses in rat blood vessels,

78

Bergen, Y., see Boulenc, X., 1471

Bengstnand, H., Eniksson, T., Hallberg, A.,Johansson, B., Karabelas, K., Mich-elsen, P. and Nybom, A.: Modulation

of neutnophil supenoxide generationby inhibitors of protein kinase C, cal-modulin, diacylglycenol and myosin

light chain kinases, and peptidyl pro-

lyl cis-traris isomerase, 1334

Berlan, M., see Tavennier, G., 1083

Bennino, L., see Caldenano, V., 579Benny, C., see Angel, I., 1327

Benson, A., see Fau, D., 69Bhat, R. V., Cole, A. J., and Baraban, J. M.:

Chronic cocaine treatment sup-presses basal expression of zif268 in

rat forebrain: In situ hybridizationstudies, 343

Bidlack, J. M., see Selley, D. E., 99Biggio, G., see Serra, M., 1360Bilirubin, unidine diphosphate-glucunono-

syltransferase, genetic deficiency,

benzo(a)pyrene biotransformation(rats), 334

Biotin, delivery to brain, covalent conjugate

of avidin, monoclonal antibody totransfennin receptor, 897

1 , l0-Bis(guanidino)decane, interactions be-

tween zinc and spermidine, NMDAreceptor complex, 632

Blackbounn, J., see Liu, Y., 533

Blandina, P., Johnson, D., Walcott, J., andGoldfarb, J.: Release of endogenousnorepinephnine from rat hypothala-mus by stimulation of N-methyl-D-

aspartic acid receptors, 61Blood-brain barrier

biotin delivery to brain, covalent conju-gate of avidin, monoclonal antibodyto transfenrin receptor, 897

ciprofloxacin and penfloxacin, cerebrospi-nal fluid transport and disposition

(rats), 1140

glutathione transport (rats), 964whole body and brain distribution, [‘H]

DPDPE, stability (mice), 1308

Blood flow, cardiovascular responses to co-caine, mediation, central nervoussystem (rats), 734

Blood pressureenhanced, renal hemodynamic effect, lis-

inopnil (rabbit), 158

intrathecal St-587, nociceptive reflexes

(rats), 428

positive chronotropic effect, BRL 37344

and CGP 12177 (dogs), 1083Blood vessels, contractile responses, flavon-

oid potentiation (rats), 78

Bloor, B. C., Frankland, M., Alper, G., Ray-bould, D., Weitz, J. and Shurtliff, M.:Hemodynamic and sedative effects ofdexmedetomidine in dog, 690

BMY 7378, 5-HT,A-mediated hyperpolani-

zation, CAl and CA3 hippocampalpyramidal cells (rats), 350

Boen, P., see Fransen, R., 646Boen, W. H., see Fransen, R., 646B#{246}hm,M., see Schwingen, R. H. G., 1352Bohmaken, K., see Meller, E., 462

Bollingen-Gruben, J. A., see Szabo, S., 752

Bombesin, growth of small cell lung cancercell lines, neuromedin B, cytosolic

calcium, 311Boom, S. P. A., Gnibnau, F. W. J. and Rus-

sel, F. G. M.: Organic cation trans-port and cationic drug interactions in

freshly isolated proximal tubular

cells of the rat, 445

Bost, K. L., see Shahabi, N. A., 876Boulenc, X., Bounnie, M., Fabre, I., Roque,

C., Joyeux, H., Bergen, Y. and Fabre,G.: Regulation of cytochnomeP4501A1 gene expression in a humanintestinal cell line, CaCO-2, 1471

Boulom, K., see Suh, H. H., 527

Bounnie, M., see Boulenc, X., 1471

Bousqet-Melou, A., see Tavernier, G., 1083Bowen, W. D., see Ponneca, F., 147

Boyd, R. J., see Jackson, W. T., 1009Bradycandia, naloxone-induced, peripheral

sympathetic nervous system, alpha-2adnenoceptors (rats), 918

Bradykinin, tracheal receptors, effect ofHoe 140 (guinea pigs), 1377

Brain

adenylate cyclase-coupled opioid receptorcomplex, opioid receptor antagonists(rats), 20

biotin delivery, covalent conjugate of av-

idin, monoclonal antibody to trans-fernin receptor, 897

cannabinoid binding site, autonadi-

ographic localization (rats), 1383

cortical slices, adnenergic neurotnansmis-

sion, potassium channel openers

(rats), 1293

distribution and stability of [‘H]DPDPE

(mice), 1308

dopamine systems in genetic mousemodel, Lesch-Nyhan syndrome, 596

dopamine uptake blockade, local anes-thetic properties, acetylcholine re-lease and cocaine (rats), 757

fetal, platelet-activating factor, arachi-donic acid release and thromboxaneB, production (rats), 562

[“51]-labeled fonskolin analogs, discnimi-nation, adenylyl cyclase and glucose

transporter (rats), 1415

labeling of novel adenosine receptor, [‘H]2-phenylaminoadenosine (rats), 552

mucaninic cholinergic receptor binding,

quantitative autonadiognaphy (rats),

1391

1992 Index 1497

noradrenengic hyperactivity, fetal cocaineexposure (rats), 413

pentobanbital activity, effects of socialisolation (mice, rats), 1036

pentobarbital-enhanced flunitnazepambinding, autoradiography (rats), 1401

receptor binding profile, DuP 734 (guineapigs), 1175

Ro 15-1788 binding, acute alcohol admin-

istration (mice), 639

Branch, C. A., see Knuepfer, M. M., 734Branch, C. A. and Knuepfer, M. M.: Adne-

nengic mechanisms underlying can-diac and vascular responses to co-caine in conscious rats, 742

Breast neoplasms, tamoxifen-nesistant cellgrowth, thionidazine/pimozide/W-13(humans), 186

Breese, G. R., see Simson, P. B., 1454

Breimen, D. D., see Jaehde, U., 1140

Brevetoxin, cooperative modulation, volt-age-dependent sodium channels, bo-vine adrenal medullany cells, 1347

Bnickman, A. S., see Bergen, M. B., 78Brink, C., see Labat, C., 800BRL 37344, CGP 12177 and, positive chron-

otnopic effect, banoneflex mechanisms(dogs), 1083

Brooks, D. P., DePalma, P. D. and Ruffolo,R. R., Jr.: Effect of captopnil and thenonpeptide angiotensin II antago-nists, SK&F 108566 and EXP3174,

on renal function in dogs with a renalartery stenosis, 422

Brooks, D. P., see Wang, Y.-X., 1188Brown, A., see Szabo, S., 752Brown, D. R., see Hildebrand, K. R., 510

Brown, M. L., see Tesfamaniam, B., 153Buchanan, L. W., see Kerr, S. W., 285Bunting, S., see Kern, S. W., 285

Bunch, R. M., Connor, J. R., Baton, J. M.,Weitzberg, M., Laemont, K., No-

ronha-Blob, L., Sullivan, J. P. andStenanka, L. R.: NPC 15669 Inhibitsthe reversed passive arthus reactionin rats by blocking neutrophil ne-

cruitment, 933

Burke, T. F., see Mosaddeghi, M., 639Buspinone, block of prepulse inhibition,

acoustic startle reflex (rats), 486Butler, D. L., see Gordon, R. K., 997

Cadieux, A., see Claing, A., 1226Caffeine, intracellular calcium pool, angi-

nine vasopnessin-induced cAMP pro-duction, renal papillary collecting tu-bule cells (rats), 1050

Calcitonin gene-related peptide, nonadre-nengic and noncholinengic arterial di-latation, venoconstniction, mesen-

tenic vasculatune (rats), 1226

Calcium-activated DNA fragmentation, dimeth-

ylnitnosamine-induced hepatic ne-crosis (mice), 387

cytosolicmaitotoxin, basophil mediator release,

979neunomedin B, growth of small cell lung

cancer cell lines, 311

extracellulan ATP-stimulated phosphoi-nositide hydrolysis, glioma C6 cells(rats), 1248

GABA actions on GABAA receptors, gen-enal anesthetics, Xenopus oocytes,

569

gentamicin-involved hypencalciunia, in-

volved nephnon site (rats), 293induction of exocytosis by pandaxin, bo-

vine adrenal medullary chromaffin

cells, 1317

influx, nicotinic receptor-evoked release,acetylcholine and somatostatin(guinea pigs), 1

interactions between zinc and spenmidine,

NMDA receptor complex, 632intracellular pool, arginine vasopressin-

induced cellular cAMP production,renal papillary collecting tubule cells(rats), 1061

mechanism for hepatotoxicity, nilutamide(rats), 69

muscaninic receptor subtypes, human

neuroblastoma cell lines, 1487Calcium-45, efflux from pancreatic islets,

effects of tacnine, insulin secretion(rats), 494

Calcium channelantagonists, inhibitory effects, neurogenic

response of vas deferens (guinea

pigs), 214

density in tissue, chronic administration,

verapamil (rats), 540

L-type, suppression by imipramine, dorsalroot ganglia (mice), 49

L-type inhibitors, serotonin-exposed con-

onany and internal mammary arter-ies, potency (humans), 112

Calcium current, voltage-dependent, inhi-

bition by papavenine, tracheal

smooth muscle cells (guinea pigs),

194

Calderano, V., Pannillo, C., Giovane, A.,

Greco, R., Matena, M. G., Bennino, L.and Rossi, F.: Antiflammins suppressthe A23187- and arachidonic acid-dependent chloride secretion in nab-

bit distal colonic mucosa, 579

Callaway, C. W. and Geyen, M. A.: Tolen-ance and cross-tolerance to the acti-vating effects of 3,4-methylenediox-

ymethamphetamine and a 5-hydroxytnyptamine,B agonist, 318

Calmodulinantagonist W- 13, tamoxifen-nesistant

breast cancer cell growth (humans),186

inhibitors, modulation, neutrophil super-

oxide generation, 1334Calphostin, role of protein kinase C, short-

term transmission, mammalian neu-

romuscular junction, 1269

Camden, J. M., see Turner, J. T., 708Cannabinoid, binding site in brain, autona-

diographic localization (rats), 1383

Cannula-inserting method, beta adrenocep-ton agonists, common carotid arteries(rabbits), 457

Capasso, A., see Pieretti, S., 830

Capsaicin, nonadnenergic and noncholi-nengic arterial dilatation, venocon-stniction, calcitonin gene-related pep-

tide (rats), 1226

Captopnil

baroneflex control of heart rate, heart fail-une after myocandial infarction (rats),

1424

diltiazem and, glomenulan hemodynamics,clipped kidney (rats), 938

SK&F 108566 and EXP3174, renal func-tion, renal artery stenosis (dogs), 422

Canamelo, C., see Cernadas, M. R., 10235-Carboxyamidotryptamine, 5-HT,A-me-

diated hypenpolanization, CAl and

CA3 hippocampal pyramidal cells(rats),350

3-Carboxy-4-methyl-5-pnopyl-2-furanpro-

panoic acid, renal organic acid trans-

port, inhibition of plasma proteinbinding, uremia (rats), 54

Canlson, B. X., Mans, A. M., Hawkins, R.A. and Baghdoyan, H. A.: Pentobar-bital-enhanced [‘H]flunitnazepambinding throughout the rat brain: Anautonadiographic study, 1401

Cannuba, M. 0., see Nisoli, E., 823

Carvedilol, antioxidant and free radicalscavenger (rats), 92

Casado, S., see Cennadas, M. R., 1023Catalepsy, tolerance, NMDA receptor an-

tagonists (pigeons), 499Catecholamines

contractile responses in blood vessels, fla-vonoid potentiation (rats), 78

induction of exocytosis, pandaxin, bovineadrenal medullany chromaffin cells,1317

YM617, alpha-i adrenocepton nadioligand(rats), 201

Cations, organic, transport and cationicdrug interactions, proximal tubularcells (rats), 445

Catravas, J. D. see Marczin, N., 170Central nervous system

cardiovascular responses to cocaine(rats), 734

H, receptor agonist Imetit (rats, mice),304

inhibited flumazenil binding, central w

site ligands (rats), 884

Cerebellan granule cells, pnopylbenzilylcho-

line mustard, specificity for musca-

ninic m, receptors (rats), 703Cerebrospinal fluid, transport and disposi-

tion, cipnofloxacin and perfioxacin(rats), 1140

Cennadas, M. R., L#{244}pez-Farr#{233},A., Riesco,A., Gallego, M. J., Espinosa, G., Di-giuni, E., Hennando, L., Casado, S.

and Canamelo, C.: Renal and sys-temic effects of aminoacids adminis-tered separately: Comparison be-tween L-arginine and non-nitric ox-ide donor aminoacids, 1023

CGP 12177, BRL 37344 and, positive chron-

otropic effect, baroneflex mechanisms

(dogs), 1083

CGS 19755, tolerance to cataleptic effect,N-methyl-D-aspartate receptor an-

tagonists (pigeons), 499

Chaki, K., see Sakunada, S., 793Chang, C., see Liu, W., 608Chang, C.-T., see Bergen, M. E., 78

Chaudhuni, G., see Fukuto, J. M., 546

Chelating agents, mechanistic study on en-hancement, rectal permeability, in-sulin (rabbits), 25

Chemla, D., see Benegi, J.-P., 1369Chemotaxis

leukotniene B4-induced neutrophil acti-vation, specific inhibition, LY223982

(guinea pigs, humans), 1009polymorphonuclear cells, morphine sul-

fate effects (monkeys), 533Chen, F., see Zhang, Z.-H., 40Chen, L. L., see Lin, L.-H., 569

1498 Index Vol. 263

Cheng, H.-Y., see Yue, T.-L., 92

Chen J-W., see Lin, J. H., 105

Chiang, K., see Fukuto, J. M., 546Chiang, P. K., see Gordon, R. K., 997

Chiang, P. K., see Kostka, P., 226Chiba, S., see Fujiwana, T., 457

Chiba, S., see Furukawa, Y., 627

Chiono,M.,seeAndazola,J.J., 1111Chloride, A23187- and anachidonic acid-de-

pendent secretion, antiflammins, dis-tal colonic mucosa (rabbits), 579

m-Chlonophenylpipenazine, -induced neu-noendocnine changes, senotonin re-

ceptor subtype-selective antagonists(rats), 588

Choi, J. J., Huang, G.-J., Shafik, E., Wu,W.-H., and McArdle, J. J.: Imipra-mine’s selective suppression of an L-

type calcium channel in neurons ofmunine dorsal root ganglia involvesG proteins, 49

Choi, K. C., see Beck, S. G., 350Cholecystokinin, regulation of messenger

RNA content, stniatum (rats), 368Cholinesterase, decreased plasma activity,

enhancement of cocaine toxicity

(mice), 698Chnistoffenson, C. L., see Pugsley, T. A.,

1147

Chromaffin cells

adrenal, neuropeptide Y inhibition, for-skolin-stimulated adenylate cyclase,1479

bovine adrenal medullary, induction of

exocytosis, pandaxin, 1317

Chuang, L. F., see Liu, Y., 533Chuang, R. Y., see Liu, Y., 533Cicero, T. J., see Little, P. J., 1056

Cieslinski, L. B., see Torphy, T. J., 1195

Ciprofloxacin, perfioxacin and, cenebrospi-nal fluid transport and disposition(rats), 1140

Claing, A., T#{233}l#{233}maque,S., Cadieux, A.,Founnien, A., Regoli, D. and D’Onl#{233}-

ans-Juste, P.: Nonadrenengic andnoncholinergic arterial dilatation and

venoconstniction are mediated by cal-citonin gene-related peptide, and

neurokinin- 1 receptors, respectively,

in the mesentenic vasculatune of the

rat after penivasculan nerve stimula-tion, 1226

Clarkson, C. W., see Liu, W., 608Clonidine, role of adrenergic receptors, mi-

tiation of vomiting, GI motor come-lates (dogs), 395

Clozapine, discriminative stimulus, 5-HT,�and 5-HT, receptors (pigeons), 276

Culman, J., see Veltman, A., 1253Cocaine

acetylcholine release and, dopamine up-

take blockade, local anesthetic prop-erties (rats), 757

cardiovascular responsesadnenengic mechanisms (rats), 742mediation, central nervous system

(rats), 734

chronic treatment, suppression of zif268basal expression, forebrain (rats), 343

-dependent men, plasma adrenocortico-tropic hormone, luteinizing hormoneand prolactin levels, 505

fetal exposure, noradrenergic hypenactiv-ity, brain (rats), 413

toxicity, decreased plasma cholinesterase

activity (mice), 698

Cohen, G., see Vatier, J. L., 1206

Cohen, M. L., see Cushing, D. J., 123Cohen, R. A., see Tesfamaniam, B., 153Cohen, S. J., see Kohlhepp, S. J., 1464Cole, A. J., see Bhat, R. V., 343Collins, A. C., see de Fiebre, N. C., 232Colon, entenic neurons, oxidant-evoked me-

lease, acetylcholine (rats), 1068

Colonic mucosa, distal, suppression of chlo-ride secretion, antiflammins (nab-

bits), 579

Columbo, M., Taglialatela, M., Warner, J.A., MacGlashan, D. W., Jr., Yasu-

moto, T., Annunziato, L. and Ma-

none, G.: Maitotoxin, a novel activa-ton of mediator release from human

basophils, induces lange increases in

cytosolic calcium resulting in hista-

mine, but not leukotniene C4, release,

979

Compton, D. R., Gold, L. H., Ward, S. J.,Balsten, R. L. and Martin, B. R.: Ami-noalkylindole analogs: Cannabimi-

metic activity of a class of compoundsstructurally distinct from �9-tetrah-ydnocannabinol, 1118

Concas, A., see Senna, M., 1360

Connon, J. R., see Bunch, R. M., 933w-Conotoxin, calcium channel antagonists

and, inhibitory effects, neunogenic me-sponse of vas defemens (guinea pigs),

214

Considine, R. V., Sherwin, J. R. and Simp-

son, L. L.: Role of protein kinase Cin short-term transmission at themammalian neuromuscular junction,1269

Cook, L., see Tam, S. W., 1167Cook, L., Tam, S. W. and Rohnbach, K. W.:

DuP 734 [1-cyclopropylmethyl)-4-

(2’(4’ ‘-fluorophenyl)-2’-oxoe-

thyl)pipenidine HBm], a potential

antipsychotic agent: Preclinical be-

havioral effects, 1159

Cook, V. A., see Leeder, J. S., 360

Conbin, A., see Pugsley, T. A., 1147Concoman, G. B., see Ray, S. D., 387

Cornfield, L. J., Hu, S., Hurt, S. D. andSills, M. A.: [‘H]2-Phenylaminoad-

enosine ([‘H]CV 1808) labels a novel

adenosine receptor in rat brain, 552Cornea-Sales, C., Nacif-Coelho, C., Reid, K.

and Maze, M.: Inhibition of aden-ylate cyclase in the locus coeruleusmediates the hypnotic response to analpha, agonist in the rat, 1046

Corticotmopin releasing factor, differential

actions, basolatenal and central

amygdaloid neunones (mats), 846

Coudray, N., see Beregi, J.-P., 1369

Coy, D. H., see Moody, T. W., 311Craft, R. M., see Picker, M. J., 668Crass, D., see Szabo, B., 806Criswell, H. E., see Simson, P. E., 1454Croce, K., see Li, T., 928Crofton, K. M., see St. Claim, M. B. G., 1432

Cromakalim

adrenengic neunotransmission, MRb+ ef-flux, brain cortical slices (rats), 1293

U-89,232 and, limitation of myocardialinjury, vascular vs. cardiac actions

(guinea pigs), 1261

Culp, S. G., Rominger, D., Tam, S. W. and

De Souza, E. B.: [‘H]Dup 734 [1-(Cyclopnopylmethyl)-4-(2’(4’ ‘-fluo-

mophenyl)- 2’-oxoethyl)-pipenidine

HBr]: A receptor binding profile of ahigh-affinity novel sigma receptor li-gand in guinea pig brain, 1175

Cushing, D. J. and Cohen, M. L.: Semotonin-

induced relaxation in canine cono-nary artery smooth muscle, 123

Cuthbert, N. J., see Labat, C., 800

CV 1808, see 2-Phenylaminoadenosine

Cyclic AMP

arginine vasopressin-induced production,

intracellular calcium pool, renal pap-

illamy collecting tubule cells (rats),

1061

automadiographic localization, dopaminereceptors, epicardial arteries (hu-mans), 1447

inhibition of adenylate cyclase, mediation

of hypnotic response, alpha, agonist

(mats), 1046

inhibition of forskolin-stimulated aden-

ylate cyclase, neuropeptide Y, bovine

adrenal chmomaffin cells, 1479

isoproterenol-stimulated accumulation,

M2 muscaninic receptors, intestinalsmooth muscle (rats), 221

papavemine inhibition, voltage-dependentCa� current, tracheal smooth muscle

(guinea pigs), 194

-phosphodiestemases, inhibition by R80122, heart (humans), 6

potentiation of production, thrombin, hu-

man erythnoleukemia cell line, 708

signal transduction mechanisms, alpha-2C and alpha-lA adrenoceptons,

prostaglandin synthesis (rabbits),

987

-specific phosphodiesterase activity, stim-

ulation of beta adrenoceptoms, U937

cells, 1195Cyclic GMP

nitmovasodilator- and endothelium-de-mived, methylene blue mechanism, an-

tenial smooth muscle cells (rabbits),

170

pharmacological profile of HS-142-1 (cat-

tle), 241renal and systemic effects, aminoacids

(rats), 1023

Cyclooxygenaserelaxation of trachea, release of prosta-

glandin E,, neumokinin NK-i mecep-

ton (rats), 767

suppression of chloride secretion, anti-

flammins, distal colonic mucosa (nab-bits), 579

ZV�-Cyclopentyladenosine, endogenous

adenosine/A1 receptor interactions,

experimental paradigm, 657

Cysteamine, -related thiols and amines, so-

matostatin depleting potency (rats),752

Cytochnome P-450

benzo(a)pynene biotransformation andbinding, genetic deficiency, bilimubin

unidine diphosphate-glucunonosyl-

transfemase (mats), 334

human antibodies, aromatic anticonvul-

sant-induced hypersensitivity meac-tions, 360

Cytochnome P-450 2D6, polymorphism of

dextromethorphan metabolism, en-

1992 Index 1499

cainide administration (humans),780

Cytochnome P45OIA1, regulation of gene

expression, human intestinal cellline, 1471

Cytoskeleton, mechanism for hepatotoxic-

ity, nilutamide (mats), 69

Czubryt, M. P., see Lonsbermy, B. B., 540

D-16949, discriminative effects (rats), 1015

Dal Toso, R., see Skaper, S. D., 1440

4-DAMPinhibition of pilocarpine responses, mus-

caninic receptor subtype antagonists

(monkeys), 1133

muscaninic cholinergic receptor binding,

quantitative autoradiography, brain(mats), 1391

Dam Trung Tuong, M., see Ganbang, M., 304Daniel, E. E., see Kostka, P., 226

Da Silva, A., see Tmifilieff, A., 1377

Davis, L. L., see Yue, T.-L., 92Davis, T. P., see Weben, S. J., 1308de Boen, A. G., see Jaehde, U., 1140De Boer, T., see Flonijn, W. J., 787

Debonnel, G., see Monnet, F. P., 1212, 1219de Chaffoy de Courcelles, D., de Loome, K.,

Freyne, E., and Janssen, P. A. J.:Inhibition of human cardiac cyclic

AMP-phosphodiestemases by R 80

122, a new selective cyclic AMP-phosphodiestenase III inhibitor: Acomparison with other cardiotoniccompounds, 6, 6 de Loore, K., see deChaffoy de Councelles

Deck, C. C., Raya, T. E., Gaballa, M. A. andGoldman, S.: Barorefliex control of

heart rate in rats with heart failure

after myocandial infarction: Effects

ofcaptopmil, 1424de Fiebme, N. C., Manley, R. J., Wehner, J.

M., and Collins, A. C.: Lipid solubil-ity of sedative-hypnotic drugs influ-

ences hypothermic and hypnotic me-sponses of long-sleep and short-sleep

mice, 232

DeLander, G. E., Mosbeng, H. I. and Pom-neca, F.: Involvement of adenosine inantinociception produced by spinalor supraspinal neceptor-selective

opioid agonists: Dissociation fromgastrointestinal effects in mice, 1097

Demattos, S., see Pugsley, T. A., 1147de Montigny, C., see Monnet, F. P., 1212,

1219

DePalma, P. D., see Brooks, D. P., 422[D-Amg’]-Dermorphin tnipeptide analogs,

antinociceptive mechanisms (mice),793

Derrick, B. E., Rodriguez, S. B., Lieberman,

D. N. and Martinez, J. L., Jr.: Muopioid receptors are associated withthe induction of hippocampal mossyfiber long-term potentiation, 725

De Souza, E. B., see Appel, N. M., 1415De Souza, E. B., see Culp, S. G., 1175

Dessy, C., see Godfnaind, T., 112Devillien, P., Acken, G. M. Adveniem, C.,

Mamsac, J., Regoli, D.and Frossand,N.: Activation of an epithelial neu-

rokining NK-lneceptor induces me-

laxation of rat trachea through me-lease ofpmostaglandin E,, 762

De Vnies, T. J., see Schoffelmeer, A. N. M.,

20

DeWald, H. A., see Pugsley, T. A., 1147

Dexamethasone, prevention of epileptiform

activity, induction by morphine (nab-

bits), 830

Dexmedetomidine, hemodynamic and seda-tive effects (dogs), 690

Dextran, allostemic modulation of M, mus-

caninic receptor binding, receptor-

mediated inhibition, adenylate cy-

clase (rats), 910

Dextmomethorphan, polymorphism of me-tabolism, encainide administration

(humans), 780

Dextmonphan, tolerance to cataleptic effect,N-methyl-D-aspartate receptor an-

tagonists (pigeons), 499

Diacylglycenol, inhibitors, modulation, neu-

tmophil superoxide generation, 1334

Diamond, J., see Meller, E., 462

Diazepam, pharmacology of r-aminobutyricacidA receptor complex, abecarnil

(mats), 1360

Diazoxide, ad.menemgic neumotransmission,�Rb� efflux, brain cortical slices(mats),1293

Diet, amilonide-sensitive lithium neabsorp-

tion, micropunctume study (rats), 646Di-(2-ethylhexyl)phthalate, induction of

peroxisomal enzyme activities, pama-thyroid replants (rats), 1105

di Giannuamio, A., see Pieretti, S., 830

Digiuni, E., see Cemnadas, M. R., 1023Digoxin, transport by human P-glycopro-

tein, LLC-PK1 cells, 840

3,5-Diiodothymopropionic acid, cardiac ef-

fects (rats), 163

Diltiazem

captopnil and, glomerular hemodynamics,clipped kidney (mats), 938

potency, serotonin-exposed coronary and

internal mammary arteries (hu-

mans), 112

Dimethylnitrosamine, -induced hepatic ne-crosis, Ca�-activated DNA fragmen-

tation (mice), 387

Ding, X.-Z. and Mocchetti, I.: Regulation of

cholecystokinin mRNA content in

mat stniatum: A glutamatengic hy-pothesis, 368

Dionne, C. A., see Jarvis, M. F., 253i,3-Dipnopyl-8-cyclopentylxanthine, endog-

enous adenosine/A, receptor inter-

actions, experimental paradigm, 657

Diquat, -induced oxidative stress in liver,

marked intemanimal differences(mats), 1003

Discriminative stimulus

clozapine, 5-HT1� and 5-HT, receptors

(pigeons), 276

D-16949 (mats), 1015

Diuresis, renal and systemic effects, ami-

noacids (rats), 1023

Dizocilpine, interactions between zinc andspemmidine, NMDA receptor com-

plex, 632DNA, Ca�-activated fragmentation, di-

methylnitrosamine-induced hepaticnecrosis (mice), 387

Docherty, J. C., see Lonsbemry, B. B., 540L-Dopa, induction of opposing effects on

pain (rats), 470

Dopamineautoreceptor agonist, pharamcological

chamactemization, PD 1 18717 (mice),1147

brain, genetic mouse model, Lesch-Nyhansyndrome, 596

carrier-mediated stniatal release, effect of

ampemozide (rats), 180inhibition of prolactin secretion, receptor

inactivation, 17f3-estradiol and per-

tussis toxin (rats), 462

locally applied, clearance and diffusion,normal and 6-hydnoxydopamine-le-sioned stniatum (rats), 1285

noradrenergic hyperactivity, fetal cocaine

exposure, brain (rats), 413receptor binding profile, DuP 734, brain

(guinea pigs), 1175receptors, autonadiognaphic localization,

epicandial arteries (humans), 1447suppression of zif268 basal expression,

chronic cocaine treatment, forebrain

(rats),343uptake blockade, local anesthetic proper-

ties, cocaine and acetylcholine re-lease (rats), 757

Dondal, M. S., Winter, J. N. and Atkinson,A. J., Jr.: Kinetic analysis of P-gly-coprotein-mediated doxorubicin ef-flux, 762

D’Onleans-Juste, P., see Claing, A., 1226Dorsal root, ganglia, suppression of L-type

calcium channel, imipramine (mice),49

Dowd, F. J., see Porter, J. E., 1062

Doxorubicin, P-glycoprotein-mediated ef-flux, kinetic analysis (humans), 762

DPDPE, whole body and brain distribution,stability (mice), 1308

Dnieu la Rochelle, C., Richard, V., Dubois-

Rand#{233},J.-L., Roupie, E., Giudicelli,J.-F., Hittinger, L. and Berdeaux, A.:Potassium channel openers dilate

large epicardial coronary arteries inconscious dogs by an indirect, endo-

thelium-dependent mechanism, 1091Drug delivery, biotin delivery to brain, co-

valent conjugate of avidin, monoclo-

nal antibody to transfemnin receptor,897

Dubo, D. F., see Lonsberry, B. B., 540Dubois-Rand#{233}, J.-L., see Dnieu la Rochelle,

C., 1091Dumaine, R., see Schanne, 0. F., 1233

Duncan, G. E., see Simson, P. E., 1454

DuP 734

preclinical behavioral effects (mice), 1159receptor binding, electmophysiological and

neurophammacological profiles

(guinea pigs), 1167receptor binding profile, high-affinity

novel sigma receptor ligand (guineapigs), 1175

Dunand, A., see Benavides, J., 884Dunham, S. K., see Ogletnee, M. L., 374

Dykstra, L. A., see Picker, M. J., 668Dytko, G., see Albmightson, C. R., 404

Egi, Y., see Suzuki, Y., 956Ehlert, F. H., see Griffin, M. T., 221Ehlert, F. J., see Genstin, E. H., Jr., 910

Eicosanoids, thrombin effect, prostaglandin

production, glomerulan mesangialcells (mats), 404

Ellingboe, J., see Mendelson, J. H., 505Encainide, administration, polymorphism,

dextromethomphan metabolism (hu-

mans), 780

Endocytosis, targeted delivery, human me-

1 500 Index Vol. 263

Gaballa, M. A., see Deck, C. C., 1424

combinant superoxide dismutase,chemical modification, 971

f1-Endorphinmu and delta opioid receptor-coupled G-

protein activity, 99naloxone-insensitive receptor, antisera

characterization, U937 cells (nab-bits), 876

Endothelial cells, dysfunction, aldose reduc-tase and myo-inositol, elevated glu-cose (rabbits), 153

Endothelin-i

big endothelin-1 and, modulation of com-

onamy vascular tone, severity of ische-mia (mats), 1074

vasoconstmictor and vasodilatom effects,

serotonin, kidney (rabbits), 928

Endotheliumdilation of large epicandial coronary artem-

ies, potassium channel openers

(dogs), 1091

pulmonary accumulation of propnanolol,

physiochemical mechanism (sheep),

130Endothelium-demived relaxing factor

-induced cyclic GMP accumulation,mechanism of methylene blue action,pulmonary arterial smooth muscle

(rabbits), 170

pharmacological activity of nitmoxyl (nab-bits), 546

renal and systemic effects, aminoacids(rats), 1023

5-nitrosothiols, smooth muscle relaxing

activity, bovine retractor penis inhib-

itory factor (rabbits), 285Enkephalin, mechanistic study on enhance-

ment, rectal permeability, insulin

(rabbits), 25

[Met5]-Enkephalin, prolonged stimulationof bovine adrenal chromaffin cells,anachidonic acid and prostaglandin

E, (cattle), 527

[D-Pen’,D-Pen5]Enkephalin, whole bodyand brain distribution, stability(mice), 1308

Epilepsy

basolatenal and central amygdaloid neu-nones, differential actions, corticotno-pin releasing factor (rats), 846

prevention of epileptiform activity, dexa-

methasone, induction by morphine

(rabbits), 830

Epitheliumeffect of Hoe 140, tracheal bradykinin

receptors (guinea pigs), 1377neurokinin NK-1 receptor, relaxation of

trachea, release of prostaglandin E,(rats), 767

Erdmann, E., see Schwinger, R. H. G., 1352Emiksson, T., see Bergstnand, H., 1334

Erythnoleukemia cells, human cell line, p0-tentiation of cyclic AMP production,thrombin, 708

Escande, D., see Beregi, J.-P., 1369Espinosa, G., see Cennadas, M. R., 1023

Estnadiol, effects of intrauterine position,hepatic microsomal polysubstratemonooxygenase (mats), 32

1 7f.�-Estmadiol, pertussis toxin and, receptorinactivation, dopaminergic inhibitionof prolactin secretion (mats), 462

Ethanol

chronic treatment, development of cross-

tolerance, other alcohols and pento-barbital (mice), 480

influences of sedative-hypnotic drugs

(mice), 232

prevention of Adniamycin toxicity, liver(mats), 651

Ethmozine, rate-dependent effects, conduc-tion and sodium current, newborn

heart (dogs), 608

Etomphine, inhibition of tail-flick response,

supmaspinal s and �z opioid receptors

(mice), 246

Eugene, D., see Fau, D., 69Exocytosis, induction by pandaxin, bovine

adrenal medullamy chromaffin cells,

1317

EXP3174, captopmil and SK&F 108566,renal function, renal artery stenosis(dogs), 422

Fabme, G., see Boulenc, X., 1471Fabre, I., see Boulenc, X., 1471

Facci, L., see Skaper, S. D., 1440

Fannin, R., see Suh, H. H., 527

Fau, D., Benson, A., Eugene, D., Fromenty,

B., Fisch, C., and Pessayre, D.: Mech-anism for the hepatotoxicity of the

antiandrogen, nilutamide. Evidence

suggesting that redox cycling of this

nitmoaromatic drug leads to oxidative

stress in isolated hepatocytes, 69

Fenoy, J., see Yamaguchi, Y., 905Femnhout, B. J. H., see Rainnie, D. G., 846Femmante, F., see Amenta, F., 1447

Fetus

cocaine exposure, nonadmenergic hypemac-tivity, brain (mats), 413

effects of intrauterine position, hepatic

microsomal polysubstrate monooxy-

genase (rats), 32

Feuemstein, G., see Yue, T.-L., 92Feuemstein, R., see Yue, T.-L., 92

Feuemstein, T. J., see Lupp, A., 717Fibroblast growth factor, acidic, binding to

FGF-flg, NIH-3T3 cells, 253

Fisch, C., see Fau, D., 69FK453, endogenous adenosine/A1 receptor

interactions, experimental paradigm,

657

FK506, modulation of neutmophil superox-ide generation, kinase inhibitors,

1334

Flavonoid, potentiation of contractile re-sponses, blood vessels (rats), 78

Fleming, W. W., see Leedham, J. A., 15

Flomijn, W. J., De Boer, T., Tonnaem, J. A.

D. M., Versteeg, D. H. G.: Character-ization of the inhibitory effect of ad-

renocorticotropin/melanocyte-stim-

ulating hormone-like peptides on the

binding of dopamine receptor ligands

to the dopamine D2 receptor in vitro,

787

Flumazenil, inhibited binding in centralnervous system, central w site ligands

(rats), 884

Flunitnazepam, pentobarbital-enhancedbinding, brain (rats), 1401

Foddi, M. C., see Serma, M., 1360Follmer, C. H., see Zhang, Z.-H., 40

Forebrain, suppression of zif268 basal

expression, chronic cocaine treat-

ment (mats), 343

Fommalin, test, antinociceptive actions,spinal NSAIDS (rats), 136

Forskolin

[“-I]-labeled analogs, adenylyl cyclase,

glucose transporter (rats), 1415

-stimulated adenylate cyclase, inhibition

by neumopeptide Y, bovine adrenal

chromaffin cells, 1479

Fourniem, A., see Claing, A., 1226

Foumniem, A., see Monnet, F. P., 1212, 1219

Fox, M., see Grover, G. J., 1074

FR121196, memory impairment, passive

avoidance and radial arm tasks

(rats), 436

France, C. P., see Lu, Y., 499

Frankland, M., see Bloom, B. C., 690

Fransen, R., Boer, W. H., Boer, P. and Koo-

mans, H. A.: Amilonide-sensitive lith-ium reabsorption in rats: A micro-

puncture study, 646Free radicals, scavenger and antioxidant,

carvedilol (mats), 92

Frei, U., Schindler, R., Matthies, C. and

Koch, K.-M.: Glomerular hemody-

namics of the clipped kidney: Effects

of captopnil and diltiazem, 938

Frey, K. A. and Howland, M. M.: Quanti-tative automadiognaphy of muscaninic

cholinengic receptor binding in the

rat brain: Distinction of receptor sub-

types in antagonist competition as-

says, 1391

Freyne, E., see de Chaffoy de Courcelles, 6Friedmann, T., see Jinnah, H. A., 596

Fnoelich, L. L., see Jackson, W. T., 1009

Fmomenty, B., see Fau, D., 69Frossard, N., see Devillier, P., 767

Fu-Cheng, X.-M., see Vatier, J. L., 1206

Fujimoto, J. M., see Xu, J. Y., 246Fujita, A., see Hata, F., 214

Fujita, T., Nishikawa, M., Tamaki, C., Tak-

akuma, Y., Hashida, M. and Sezaki,H.: Targeted delivery of human re-combinant superoxide dismutase by

chemical modification with mono-

and polysacchanide derivatives, 971Fujiwama, T. and Chiba, S.: Vascular alpha-

1 antagonistic and agonistic effects

of beta adrenoceptor agonists in rab-

bit common carotid arteries, 457

Fukuto, J. M., Chiang, K., Hszieh, R.,Wong, P. and Chaudhuri, G.: The

pharmacological activity of nitroxyl:

A potent vasodilator with activitysimilar to nitric oxide and/or endo-

thelium-denived relaxing factor, 546

Funck-Bmentano, C., Thomas, G., Jacqz-Aigrain, E., Poinier, J.-M., Simon, T.,B#{233}r#{233}ziat,G. and Jaillon, P.: Polymor-

phism of dextromethorphan metabo-

lism: Relationships between pheno-

type, genotype and response to the

administration of encainide in hu-

mans, 780

Fura-2, nicotinic receptor-evoked release,

acetylcholine and somatostatin,

myenteric plexus (guinea pigs), 1

Furan dicarboxylic acid, renal transport, in-

hibition of plasma protein binding,

uremia (rats), 54

Furukawa, Y., Takayama, S., Ren, L.-M.,Sawaki, S., Inoue, Y. and Chiba, S.:

Blocking effects of Vi (OPC-21268)

and V2 (OPC-31260) antagonists onthe negative inotropic response to va-

sopressin in isolated dog heart prep-

amations, 627

1992 Index 1501

Gabelt, B. T. and Kaufman, P. L.: Inhibitionof outflow facility and accommoda-

tive and miotic responses to pilocan-

pine in rhesus monkeys by musca-

ninic receptor subtype antagonists,

1133

Gadwood, R. C., see Toombs, C. F., 1261Gaginella, T. S., Gnisham, M. B., Thomas,

D. B., Walsh, R. and Moummi, C.:Oxidant-evoked release of acetylcho-line from entenic neurons of the mat

colon, 1068

Galitzky, J., see Tavemnier, G., 1083

Gallego, M. J., see Cennadas, M. R., 1023

Galzin, A. M., see Angel, I., 1327Ganellin, C. R., see Garbang, M., 304Ganglia

dorsal root, suppression of L-type calcium

channel, imipramine (mice), 49

nodose, characterization of YMO6O, N1E-

115 neuroblastoma cells (rabbits),

1127

Ganglioside, GM1, protective effects, 2,4,5-

tnihydnoxyphenylalanine, 1440

Gao, Z., see Vatier, J. L., 1206Gapinski, D. M., see Jackson, W. T., 1009Garbarg, M., Anrang, J.-M., Rouleau, A.,

Ligneau, X., Dam Trung Tuong, M.,

Schwartz, J. C., and Ganellin, C. R.:S-[2-(4-imidazolyl)ethyl]isothiourea,

a highly specific and potent hista-mine H, receptor agonist, 304

Gandiner, P., see Labat, C., 800Garland, H. 0., Phipps, D. J., and Harpur,

E. S.: Gentamicin-induced hypercal-

ciunia in the rat: Assessment of neph-

mon site involved, 293

Gastric acid, gastroprotective effects,

thromboxane receptor antagonists(rats),374

Gastric mucosa, antacid and, interaction,“artificial stomach” model, 1206

Gastrointestinal tract

involvement of adenosine in antinocicep-tion, spinal or supraspinal receptor-

selective opioid agonists (mice), 1097

motor correlates, role of adrenergic recep-tons, initiation of vomiting (dogs),

395Gaviraghi, G., see Giacometti, A., 1241

Ge, B.-L., see Roy, S., 451

Genecytochrome P45OIA1, regulation of

expression, human intestinal cellline, 1471

influences of sedative-hypnotic drugs

(mice), 232

proenkephalin, adrenal chromaffin cell

stimulation, arachidonic acid and

prostaglandin E, (cattle), 527

suppression of zif268 basal expression,

chronic cocaine treatment, forebrain(mats), 343

Gentamicindeterminants of in vitro interaction, po-

lyspartic acid, aminoglycoside anti-

biotics, 1464

-induced hypercalciunia (rats), 293Gepinone, block of prepulse inhibition,

acoustic startle reflex (rats), 486Gerber, J. G., see Payne, N. A., 520

Gerhardt, G. A., see van Home, C., 1285

Gerstin, E. H., Jr., Luong, T. and Ehlert, F.J.: Hepanin, dextran and trypan blueallosterically modulate M, musca-

rinic receptor binding properties and

interfere with receptor-mediated in-

hibition of adenylate cyclase, 910

Gessner, G. W., see Jarvis, M. F., 253

Geyer, M. A., see Callaway, C. W., 318Ghiani, C. A., see Semra, M., 1360Giacometti, A., Quartamoli, M., Gaviraghi,

G., Micheli, D. and Tnist, D.: Analy-Sis of the interaction between lacidi-pine and BAY K 8644 in two isolated

rabbit arteries, 1241

GI 87084B, hemodynamic effects (dogs), 84

Gibson, V. A., see Miller, J. H., 663

Gies, J.-P., see Tnifilieff, A., 1377

Gifford, A. N. and Johnson, K. M.: Com-panison of the role of local anesthetic

properties -with dopamine uptakeblockade in the inhibition of striatal

and nucleus accumbens [‘H]acetyl-

choline release by cocaine, 757

Gilbert, D. N., see Kohlhepp, S. J., 1464Gilbert’s disease, benzo(a)pyrene biotmans-

formation and binding, genetic defi-ciency, bilirubin unidine diphos-

phate-glucuronosyltmansferase (mats),

334Gilchrist, J. S. C., see Lonsberry, B. B., 540

Gilligan, P. J., see Tam, S. W., 1167

Giovane, A., see Calderaro, V., 579

Giudicelli, J.-F., see Dnieu la Rochelle, C.,1091

Glial fibnillary acidic protein, olfactory tox-icity, �3,�3’-iminodipropionitrile

(rats), 1432

Glioma, C6 cells, extracellular ATP-stimu-

lated phosphoinositide hydrolysis

(rats), 1248

Glucoseelevated, aldose reductase and myo-ino-

sitol, endothelial cell dysfunction(rabbits), 153

transporter and adenylyl cyclase, discrim-

ination, [“5I]-labeled forskolin ana-

logs (rats), 1415

Glutamic acid, release of endogenous nor-

epinephrine, stimulation by NMDAreceptors, hypothalamus (rats), 61

L-Glutamic acid, NMDA and non-NMDA

receptors, hippocampal norepineph-

mine release (rats), 327

Glutathione

diquat-induced oxidative stress, marked

interanimal differences, liver (rats),

1003

transport at blood-brain barrier (rats),

964

Glutathione S-tmansferasebilirubin unidine diphosphate-glucunono-

syltransferase, benzo(a)pyrene bio-

transformation, genetic deficiency

(rats),334hepatic microsomal polysubstrate mon-

ooxygenase and, effects of intrautem-me position (rats), 32

Glybenclamide, membrane electrical activ-ity, detrusor muscle, pinacidil (guinea

pigs), 816

Glycine

-induced glomemular hyperfiltration, role

of adenosine (rats), 1188inhibition of NMDA-activated currents,

lead, hippocampal neurons (rats), 868

memantine and amantadine, inhibitory

effects, NMDA-evoked acetyicholine

release in caudate nucleus (rabbits),

717

ontogeny of NMDA-induced current, hip-

pocampal neurons (rats), 859Glycopynolate, hemodynamic and sedative

effects, dexmedetomidine (dogs), 690

Glycoside, reduction of toxicity, extracellu-

lan magnesium concentration, myo-candium (humans), 1352

Godfnaind, T., Dessy, C., and Salomone, S.:A comparison ofthe potency of selec-tive L-calcium channel blockers in

human coronary and internal mam-

mary arteries exposed to serotonin,

112

Gold, L. H., see Compton, D. R., 1118Goldberg, S. R., see Swedbemg, M. D. B.,

1015

Goldfanb, J., see Blandina, P., 61

Goldfrank, L. R., see Hoffman, R. S., 698Goldman, S., see Deck, C. C., 1424Goldman, S., see Pennock, G. D., 163Golub, M. S., see Bergen, M. E., 78Gordon, R. K., Gray, R. R., Reaves, C. B.,

Butler, D. L. and Chiang, P. K.: In-duced release of acetylcholine fromguinea pig ileum longitudinal muscle-myentenic plexus by anatoxin-a, 997

Gordon, R. K., see Kostka, P., 226

Gonenne, I., see Labat, C., 800Gotoh, M., see Kitanaka, J.-I., 1248G proteins

binding of dopamine receptor ligands, in-hibitory effect, adrenocorticotropin/

melanocyte-stimulating hormone-

like peptides (rats), 787

dopaminergic inhibition of prolactin se-cretion, receptor inactivation, 17f3-

estradiol and pertussis toxin (rats),462

inhibition of fonskolin-stimulated aden-

ylate cyclase, neuropeptide Y, bovineadrenal chromaffin cells, 1479

mu and delta opioid receptor-coupling, fi-endorphin effects, 99

potentiation of cyclic AMP production,

thrombin, human erythnoleukemiacell line, 708

receptor-mediated inhibition of adenylatecyclase, M, muscaminic receptor bind-ing, hepanin/dextran/trypan blue

(rats), 910

signal transduction mechanisms, alpha-

2C and alpha-lA adrenoceptors,prostaglandin synthesis (rabbits),

987

suppression of L-type calcium channel,

imipramine, dorsal moot ganglia

(mice), 49

Gray, R. R., see Gordon, R. K., 997Greco, R., see Calderaro, V., 579Greene, D. L., see Weber, S. J., 1308Gregus, Z., see Madhu, C., 1003

Gmibnau, F. W. J., see Boom, S. P. A., 445

Griffin, M. T. and Ehlert, F. H.: Specificinhibition of isoprotenenol-stimu-lated cyclic AMP accumulation byM2 muscaninic receptors in mat intes-

tinal smooth muscle, 221

Gnisham, M. B., see Gaginella, T. S., 1068Grizzle, M. K., see James, M. K., 84Groom, T., see Albnightson, C. R., 404

Groppi, V. E., see Toombs, C. F., 1261Grover, G. J., Sleph, P. G., Fox, M. and

Tnippodo, N. C.: Role of endothelin-

I 502 Index Vol. 263

1 and big endothelin-l in modulating

coronary vascular tone, contractile

function and severity of ischemia in

rat hearts, 1074

GTP-binding protein, extracellulam ATP-

stimulated phosphoinositide hydrol-

ysis, glioma C� cells (rats), 1248

Gu, J.-L., see Yue, T.-L., 92

Guanine nucleotidesacidic fibroblast growth factor binding,

FGF-flg, NIH-3T3 cells, 253

5-HTIA and adenosine A1 receptor sys-

tems, allosteric interactions, binding

sites (rats), 1275

HA-966, NMDA and non-NMDA receptors,

hippocampal norepinephrine release

(rats), 327

Hajj-ali, A. F. and Zimmerman, B. G.: En-

hanced blood pressure and renal

hemodynamic effect of chronic vs.

acute lisinopril administration in the

rabbit, 158

Halenda, S. P., see Turner, J. T., 708

Hallberg, A., see Bemgstrand, H., 1334

Haloperidol

block ofprepulse inhibition, acoustic star-

tle reflex (rats), 486

receptor binding profile, DuP 734, brain

(guinea pigs), 1175

H#{224}m#{224}l#{224}inen,H., see Kukkonen, J., 1487

Hargrove, B. K., see Picker, M. J., 668Harpur, E. S., see Garland, H. 0., 293

Harris, R. A., see Lin, L.-H., 569

Hashida, M., see Fujita, T., 971

Hashimoto, H., see Kitanaka, J.-I., 1248

Hata, F., Fujita, A., Saeki, K, Kishi, I., Tak-euchi, T., and Yagasaki, 0.: Selectiveinhibitory effects of calcium channel

antagonists on the two components

of the neurogenic response of guinea

pig vas deferens, 214

Hawkins, R. A., see Carlson, B. X., 1401

Hayakawa, A., see Yamamoto, A., 25

Heartantioxidant and free radical scavenger,

carvedilol (rats), 92

cardiovascular responses to cocaine, me-

diation, central nervous system

(rats), 734

effects of 3,5-diiodothyropropionic acid

(rats), 163

inhibition of cyclic AMP-phosphodiester-

ases, R 80122 (humans), 6

negative inotropic response, blocking ef-

fects, Vi and V2 antagonists (dogs),

627

newborn, rate-dependent effects of eth-

mozine, conduction (dogs), 608

severity of myocardial ischemia, endothe-

lin-1 and big endothelin-1 (rats),

1074

Heart failure, reduction of cardiac glycoside

toxicity, extracellular magnesium

concentration, myocardium (hu-

mans), 1352

Heart rate, barorefiex control, heart failureafter myocardial infarction, captopril(rats), 1424

Heffner, T. G., see Pugsley, T. A., 1147Heikkil#{224},J., see Kukkonen, J., 1487

Hemodynamics, GI 870MB (dogs), 84

Henderson, S. J. and Lindup, W. E.: Renalorganic acid transport: Uptake by rat

kidney slices of a furan dicarboxylic

acid which inhibits plasma protein

binding of acidic ligands in uremia,

54

Henry, G. C., see Hoffman, R. S., 698

Heparinacidic fibroblast growth factor binding,

FGF-flg, NIH-3T3 cells, 253

allosteric modulation of M, muscarinic

receptor binding, receptor-mediated

inhibition, adenylate cyclase (rats),

910

Hepatotoxicity, nilutamide (rats), 69

Herman, A. G., see Loenders, B., 773

Herman, C. A., see Andazola, J. J., 1111Hemnando, L., see Cernadas, M. R., 1023

Herzer, W. A., see Kuan, C.-J., 657

Hexum, T. D., see Zhu, J., 1479

Hidaka, K., see Ito, H., 1127

Hildebrand, K. R. and Brown, D. R.: Nor-

epinephrine and alpha-2 adnenocep-

tors modulate active ion transport in

porcine small intestine, 510

Hill, J. L., see Aulakh, C. S., 588

Himbacine, binding and functional selectiv-

ity, cloned and neuronal muscarinic

receptors, 663

Hippocampus

CAl and CA3 pyramidal cells, 5-HT1A-

mediated hyperpolarization (mats),

350

CA3 dorsalneuropeptide Y, NMDA response

(rats), 1212

potentiation of NMDA response, neu-

ropeptide Y (rats), 1219

5-HT1A and adenosine A1 receptor sys-

tems, allosteric interactions, binding

sites (rats), 1275

intrahippocampal injections of NMDA

receptor antagonists, scopolamine,working and reference memory

(rats), 943

memory impairment, passive avoidance

and radial arm tasks, effect of

FR121196 (rats), 436

mossy fiber long-term potentiation, in-

duction, p opioid receptors (rats), 725

neurons

inhibition of NMDA-activated cur-

rents, lead (rats), 868

ontogeny, NMDA-induced current

(rats), 859

norepinephrine release, NMDA and non-

NMDA receptors (rats), 327

prevention of epileptiform activity, dexa-

methasone, induction by morphine

(rabbits), 830

Hirai, M., see Tanigawara, Y., 840

Hisada, T., see Iguchi, M., 194Histamine

basophil mediator release, cytosolic cal-

cium increases, maitotoxin as a novel

activator, 979

gastric release, differential efects, soma-

tostatin and prostaglandins (dogs),

520

H3 receptor agonist Imetit (rats, mice),

304

Hittinger, L., see Drieu la Rochelle, C., 1091

HL-60 cells, P-glycoprotein-mediated ef-

flux, kinetic analysis (humans), 762

Hoe 140, effect on tracheal bradykinin me-ceptors (guinea pigs), 1377

Hoenicke, E. M., Vanecek, S. A., and

Woods, J. H.: The discriminativestimulus effects of clozapine in pi-

geons: Involvement of 5-

hydroxytryptamine1� and 5-

hydroxytryptamine, receptors, 276

Hoffer, B. J., see van Home, C., 1285

Hoffmann, R. S., Henry, G. C., Wax, P. M.,

Weisman, R. S., Howland, M. A. and

Goldfrank, L. R.: Decreased plasmacholinesterase activity enhances co-

caine toxicity in mice, 698

Hogenboom, F., see Schoffelmeer, A. N. M.,

20

Honda, K., see Ito, H., 1127

Honda, K., see Miyake, A., 1302

Honda, K., see Yazawa, F., 201

Hong, J.-S., see Suh, H. H., 527

Hori, M., see Berger, M. E., 78

Honi, R., see Tanigawara, Y., 840

Howell, R. E. and Lanken, P. N.: Pulmonary

accumulation of propranolol in vivo:

Sites and physiochemical mecha-

nism, 130

Howland, M. A., see Hoffman, R. S., 698

Howland, M. M., see Frey, K. A., 1391

H2-receptom antagonists, organic cation

transport, cationic drug interactions,

proximal tubular cells (rats), 445

Hruby, V. J., see Schoffelmeer, A. N. M., 20

Hruby, V. J., see Weber, S. J., 1308HS-142-i, pharmacological profile (cattle),

241

Hszieh, R., see Fukuto, J. M., 546

Hu, S., see Cornfield, L. J., 552

Hu, Z. and Wells P. G.: In vitro and in vivo

biotransformation and covalent

binding of benzo(a)pyrene in Gunn

and RHA rats with a genetic defi-

ciency in bilirubin unidine diphos-

phate-glucunonosyltransferase, 334

Huang, G.-H., see Choi, J. J., 49

Hudson, P., see Suh, H. H., 527

Human immunodeficiency virus, protease

inhibitor, dose-dependent toxicoki-

netics, L-689,502 (rats, dogs), 105

Hurt, S. D., see Cornfield, L. J., 552

6-Hydroxydopamine

-induced lesions, regional effects, dopa-mine Dl receptors (mats), 1454

-lesioned striatum, clearance and diffu-

sion, locally applied dopamine in

stniatum (rats), 1285

Hyperalgesia, induction of opposing effects

on pain, L-dopa (rats), 470

Hypercalciuria, gentamicin-induced (rats),

293

Hyperinsulinemia, adrenergic activation

and, pathogenesis, indomethacin-in-

duced antral ulcers (hamsters, rats),951

Hypersensitivity, aromatic anticonvulsant-

induced reactions, human anti-cyto-

chrome P450 antibodies, 360

Hypnotic agents, zolpidem, repeated treat-

ment, lack of tolerance and physical

dependence (mice), 298

Hypothalamic-pituitary-gonadal axis, ef-

fects of alcohol on development

(rats), 1056

Hypothalamus, release of endogenous nor-epinephnine, stimulation, NMDA me-

ceptors (rats), 61

Hypothermia, influences of sedative-hyp-

notic drugs (mice), 232

Hypoxanthine-guanine phosphonibosyl-transferase, brain dopamine systems,

1992 Index 1503

genetic mouse model, Lesch-Nyhansyndrome, 596

Ibuprofen, spinal NSAIDS, antinociceptiveactions, fonmalin test (mats), 136

Idazoxan, SL 84.0418, alpha-2 adrenocep-tons antagonist, pharmacological pro-

file, 1327

Iguchi, M., Nakajima, T., Hisada, T., Sugi-moto, T., and Kurachi Y.: On the

mechanism of papavenine inhibitionof the voltage-dependent Ca� cur-

rent in isolated smooth muscle cells

from the guinea pig trachea, 194Ileum

active ion transport in small intestine,nonepinephnine and alpha-2 adne-noceptons (pigs), 510

longitudinal muscle-myentenic plexus, in-duced acetylcholine release, ana-toxin-a (guinea pigs), 997

membrane potential in myentenic neu-rons, tolerance and dependence to

morphine (guinea pigs), 15

Im, H. K., see Zhu, Y., 207

Im, W. B., see Zhu, Y., 207

Imai, H., see Miyake, A., 1302

Imetit, histamine H, receptor agonist (rats,mice), 304

S-[2-(4-Imidazolyl)ethyl]isothiounea, H, re-cepton agonist (mats, mice), 304

/3j3’-Iminodipnopionitnile, olfactory toxicity(rats), 1432

Imipraminepulmonary accumulation of propranolol,

physiochemical mechanism (sheep),130

suppression of L-type calcium channel,

neurons, dorsal root ganglia (mice),49

Inagaki, 0., see Yazawa, F., 201

Indomethacin-induced antral ulcers, pathogenesis, hy-

peninsulinemia and adrenergic acti-vation (hamsters, rats), 951

spinal NSAIDS, antinociceptive actions,fommalin test (rats), 136

Inhibitory factor, bovine retractor penis, 5-nitrosothiols, smooth muscle relax-

ing activity (rabbits), 285Inotropy, cardiac effects, 3,5-diiodothyro-

propionic acid (rats), 163Inoue, Y., see Furukawa, Y., 627Insulin

hypeninsulinemia and adrenengic activa-tion, pathogenesis, indomethacin-in-

duced antral ulcers (hamsters, rats),951

rectal permeability, mechanistic study onenhancement (rabbits), 25

secretion, effects of tacnine, �Rb� and

45Ca’� efflux from pancreatic islets(rats), 494

Intenleukin 1, -activated thymocytes, mor-phine binding (mice), 451

Intestinedeep muscular plexus of ileum, prejunc-

tional muscaninic receptors (dogs),226

human cell line, regulation, cytochnomeP45OIA1 gene expression, 1471

smooth muscle, isopnotenenol-stimulatedcyclic AMP accumulation, M2 mus-caninic receptors (rats), 221

Intestine, small, active ion transport, non-

epinephmine and alpha-2 adrenocep-

tons (pigs), 510

Ipsapimone, block of prepulse inhibition,acoustic startle reflex (rats), 486

Ishikawa, M., see Watanabe, H., 1036Ishikawa, S., Okada, K. and Saito, T.: Mod-

ulation by intracellular calcium pool

of arginine vasopressin-induced cell-ulan cyclic AMP production in ratrenal papillary collecting tubule cellsin culture, 1050

Isoprotenenoldopamine receptor subtype, brown adi-

pose tissue, thenmogenesis (rats), 823

papavenine inhibition, voltage-dependentCa� current, tracheal smooth muscle(guinea pigs), 194

-stimulated cyclic AMP accumulation,M2 muscaninic receptors, intestinalsmooth muscle (rats), 221

Ito, H., Hidaka, K., Miyata, K., Kamato, T.,

Nishida, A. and Honda, K.: Chamac-

tenization of YMO6O, a potent andselective 5-hydnoxytryptamine, re-cepton antagonist, in rabbit nodoseganglion and N1E-115 neuro-blastoma cells, 1127

Izumi, F., see Wada, A., 1347

Jackisch, R. see Lupp, A., 717

Jackson, E. K., see Kuan, C.-J., 657Jackson, W. T., Boyd, R. J., Froelich, L. L.,

Mallett, B. E. and Gapinski, D. M.:Specific inhibition of leukotniene B4-induced neutrophil activation by

LY223982, 1009Jacqz-Aigrain, E., see Funck-Brentano, C.,

780

Jaehde, U., Langemeijer, M. W. E., de Boen,A. G. and Breimer, D. D.: Cenebro-spinal fluid transport and disposition

of the quinolones ciprofloxacin andpefloxacin in rats, 1140

Jaillon, P., see Funck-Brentano, C., 780James, M. K., Vuong, A., Grizzle, M. K.,

Schuster, S. V., and Shaffer, J. E.:

Hemodynamic effects of GI 870MB,

an ultra-short acting mu-opioid an-

algesic, in anesthetized dogs, 84

Janssen, P. A. J., see de Chaffoy de Coum-celles, 6

Jarvis, M. F., Gessner, G. W., Martin, G. E.,

Jaye, M., Ravema, M. W., and Dionne,C. A.: Characterization of [“51]acidicfibroblast growth factor binding tothe cloned human fibmoblast growth

factor receptor, FGF-flg, on NIH 3T3cell membranes: Inhibitory effects of

hepanin, pertussis toxin and guaninenucleotides, 253

Jaye, M., see Jarvis, M. F., 253

Jensen, R. T., see Moody, T. W., 311Jinnah, H. A., Langlais, P. J. and Fried-

mann, T.: Functional analysis ofbrain dopamine systems in a geneticmouse model of Lesch-Nyhan syn-drome, 596

Johansson, B., see Bergstrand, H., 1334

Johnson, D., see Blandina, P., 61

Johnson, K. B., see Simson, P. E., 1454

Johnson, K. M., see Giffond, A. N., 757Johnson, S. M., see Leedham, J. A., 15Jones, S. R., see Picker, M. J., 668

Joyeux, H., see Boulenc, X., 1471

Junevics, H. A., see Simson, P. E., 1454

Kalant, H., see L#{233},A. D., 480Kamato, T., see Ito, H., 1127

Kamendulis, L. M., see Ray, S. D., 387

Kannan, R., Kuhlenkamp, J. F., Ookhtens,M. and Kaplowitz, N.: Transport ofglutathione at blood-brain barrier of

the rat: Inhibition by glutathione an-alogs and age-dependence, 964

Kansna, S., see Turner, J. T., 708Kaplowitz, N., see Kannan, R., 964Karabelas, K., see Bergstrand, H., 1334Kanim, 0. M. A., see Seki, N., 816

Karlsson, S. and Ahr#{233}n, B.: Effects of tac-

mine on insulin secretion and s�Rb�

and 45Ca� efflux from mat pancreaticislets, 494

Kato, H., see Takata, Y., 1293

Kato, Y., see Yamamoto, A., 25Kaufman, P. L., see Gabelt, B. T., 1133

Kerr, S. W., Buchanan, L. V., Bunting, S.,and Mathews, W. R.: Evidence thatS-nitnosothiols are responsible for

the smooth muscle relaxing activity

of the bovine retractor penis inhibi-

tory factor, 285

Ketamine, tolerance to cataleptic effect, N-

methyl-D-aspartate receptor antago-nists (pigeons), 499

Ketorolac, spinal NSAIDS, antinociceptiveactions, formalin test (rats), 136

Khanna, J. M., see L#{233},A. D., 480Kidney

clipped, glomerular hemodynamics, cap-topnil and diltiazem (rats), 938

glomerular mesangial cells, thrombin ef-fect, prostaglandin production (rats),404

glycine-induced glomerular hyperfiltra-tion, role of adenosine (rats), 1188

hemodynamic effect of lisinopnil, en-hanced blood pressure (rabbit), 158

hemodynamic response to blockade,thromboxane A, and prostaglandinH, receptors, angiotensin II (mats),905

LLC-PK1 cells, digoxin transport, humanP-glycopnotein expression, 840

organic acid transport, inhibition ofplasma protein binding, uremia(rats), 54

papillary collecting tubule cells, intracel-

lular calcium pool, arginine vasopres-

sin-induced cAMP production (rats),1061

renal function with renal artery stenosis,captopnil, SK&F 108566 andEXP3174 (dogs), 422

sympathetic nerve activity, quinpinole,renal nonepinephnine spilloven (nab-bits), 806

systemic effects of aminoacids, L-anginine

and non-nitric oxide donor amino-acids (rats), 1023

vasoconstnicton and vasodilator effects,

serotonin (rabbits), 928Kikkawa, Y., see Sakai, H., 381

Killam, K. F., Jr., see Liu, Y., 533King, J., see Lin, J. H., 105

Kinins, enhanced blood pressure, renalhemodynamic effect, lisinopnil (nab-bits), 158

Kioka, N., see Tanigawana, Y., 840

Kisara, K., see Sakunada, S., 793

Kishi, I., see Hata, F., 214

Kitanaka, J.-I., Hashimoto, H., Gotoh, M.,

1504 Index Vol. 263

Mayumi, T. and Baba, A.: Mecha-nism of extracellular ATP-stimu-

lated phosphoinositide hydrolysis in

rat glioma C6 cells, 1248

Klaassen, C. D., see Madhu, C., 1003

Knuepfer, M. M., see Branch, C. A., 742Knuepfer, M. M. and Branch, C. A.: Cardi-

ovasculan responses to cocaine areinitially mediated by the central

nervous system in rats, 734

Kobayashi, H., see Wada, A., 1347

Koch, A., see Schwinger, R. H. G., 1352

Koch, K.-M., see Frei, U., 938

Koch, R., see Lupp, A., 717

Kodama, H., see Kunatani, K., 951Kohlhepp, M. E., see Kohlhepp, S. J., 1464Kohlhepp, S. J., McGregor, D. N., Cohen,

S. J., Kohlhepp, M. E. and Gilbert,

D. N.: Determinants of the in vitro

interaction of polyaspartic acid and

aminoglycoside antibiotics, 1464

Komano, T., see Tanigawara, Y., 840Kong, J.-Q., see Leedham, J. A., 15Koomans, see Fransen, R., 646

Kostka, P., Ahmad, S., Kwan, C.-Y., Daniel,E. E., Gordon, R. K., and Chiang, P.

K.: Prejunctional muscaninic recep-tons in the deep muscular plexus of

canine ileum: Comparison with

smooth muscle receptors, 226

Kuan, C.-J., Herzer, W. A. and Jackson, E.K.: An experimental paradigm for in-vestigating the role of endogenous

adenosine/A1 receptor interactions in

vivo, 657

Kuhlenkamp, J. F., see Kannan, R., 964Kukkonen, J., Ojala, P., N#{228}sman,J., Ham-

#{228}l#{224}inen,H., Heikkila, J. and Aker-

man, K. E. 0.: Muscarinic receptor

subtypes in human neuroblastoma

cell lines SH-SY5Y and IMR-32 as

determined by receptor binding, Ca�mobilization and northern blotting,1487

Kunievsky, B. and Yavin, E.: Platelet-acti-

vating factor stimulates amachidonic

acid release and enhances thrombox-

ane B’ production in intact fetal ratbrain ex vivo, 562

Kurachi, Y., see Iguchi, M., 194Kuratani, K., Yamazaki, M., Kodama, H.

and Yamaguchi, I.: Possible involve-ment of hypeninsulinemia and adre-

nergic activation in the pathogenesis

of indomethacin-induced antral ul-

cers in nonfasted hamsters and mefed

rats, 951

Kwan, C.-Y., see Kostka, P., 226

L-689,502, dose-dependent toxicokinetics

(rats, dogs), 105

Labat, C., Ortiz, J. L., Norel, X., Gonenne,I., Verley, J., Abram, T. S., Cuthbert,N. J., Tudhope, S. R., Norman, P.,

Gardiner, P. and Brink, C.: A second

cysteinyl leukotniene receptor in hu-

man lung, 800

Lacidipine, BAY K 8644 and, analysis of

interaction, arteries (rabbits), 1241

Laemont, K., see Bumch, R. M., 933Landry, Y., see Trifilieff, A., 1377

Lang, I. M. and Samna, S. K.: The role ofadrenergic receptors in the initiation

of vomiting and its gastrointestinal

motor correlates, 395Langemeijer, M. W. E., see Jaehde, U., 1140

Langer, S. Z., see Angel, I., 1327Langlais, P. J., see Jinnah, H. A., 596Lanken, P. N., see Howell, R. E., 130La Ros#{233}e,K., see Schwinger, R. H. G., 1352

Lazanovici, P. and Lelkes, P. I.: Pardaxininduces exocytosis in bovine adrenal

medullary chromaffin cells independ-

ent of calcium, 1317

L#{233},A. D., Khanna, J. M. and Kalant, H.:Effects of chronic treatment with

ethanol on the development of cross-

tolerance to other alcohols and pen-

tobarbital, 480

Lead, inhibition of NMDA-activated cur-rents, hippocampal neurons (rats),

868Lecarpentier, Y., see Benegi, J.-P., 1369

Lee, K. S., see Toombs, C. F., 1261

Lee, N. M., see Roy, S., 451

Lee, V. H., see Yamamoto, A., 25Leeden, J. S., Riley, R. J., Cook, V. A., and

Spielberg, S. P.: Human anti-cyto-

chrome P450 antibodies in aromaticanticonvulsant-induced hypersensi-

tivity reactions, 360

Leedham, J. A., Kong, J.-Q., Taylor, D. A.,Johnson, S. M., and Fleming, W. W.:

Membrane potential in myentericneurons associated with tolerance

and dependence to morphine, 15

LeFevre, R., see van der Hoeven, Th., 32

Lelkes, P. I., see Lazarovici, P., 1317

Leon, A., see Skaper, S. D., 1440

Lesch-Nyhan syndrome, brain dopamine

systems, genetic mouse model, 596

Leukotriene, second receptor in lung (hu-mans), 800

Leukotniene B4-induced neutrophil activation, specific

inhibition, LY223982 (guinea pigs,

humans), 1009

leukotmiene B5 and, binding sites on lung

membranes, contraction (frogs), 1111Leukotniene C4, basophil mediator release,

cytosolic calcium increases, maito-

toxin as a novel activator, 979

Levy, D. A., see Vatier, J. L., 1206

Li, T., Croce, K. and Winquist, R. J.: Vas-

oconstnictor and vasodilator effects

of serotonin in the isolated rabbit

kidney, 928

Lidocaine, pulmonary accumulation of pro-

pranolol, physiochemical mechanism

(sheep), 130

Lieberman, D. N., see Derrick, B. E., 725

Lieu, H.-D., see Meller, E., 462

Ligneau, X., see Garbang, M., 304Lin, J. H., Chen, I-W., and King, J.: Dose-

dependent toxicokinetics of L-689,

502, a potent human immunodefi-

ciency virus protease inhibitor, in

rats and dogs, 105

Lin, L.-H., Chen, L. L., Zimrolli, J. A. and

Harris, R. A.: General anesthetics p0-

tentiate -y-aminobutynic acid actions

on -y-aminobutyric acidA receptors

expressed by Xenopus oocytes: Lack

of involvement of intracellular cal-

cium, 569

Lindup, W. E., see Henderson, S. J., 54

Lipid penoxidation, antioxidant and freeradical scavenger, carvedilol (mats),

92

Lipids

brown adipose tissue, dopamine receptorsubtype, themmogenesis (rats), 823

chronic ethanol treatment, other alcohols

and pentobarbital, development ofcross-tolerance (mice), 480

solubility of sedative-hypnotic drugs, hy-

pothenmic and hypnotic responses,long- and short-sleep mice, 232

Lipocortins, suppression of chloride secre-

tion, antiflammins, distal colonic

mucosa (rabbits), 579

Lisinopnil, enhanced blood pressure, renal

hemodynamic effect (rabbit), 158List, T. J., see Beck, S. G., 350

Lisuride, dopamine receptor subtype, brown

adipose tissue, themmogenesis (rats),

823

Lithiumgentamicin-involved hypercalciunia, in-

volved nephron site (rats), 293reabsorption, amilomide sensitivity, mi-

cropunctune (rats), 646Little, P. J., Adams, M. L. and Cicero, T. J.:

Effects of alcohol on the hypotha-

lamic-pituitany-gonadal axis in the

developing male rat, 1056

Liu, W., Clarkson, C. W., Yamasaki, S.,

Chang, C., Stolfi, A. and Pickoff, A.

S.: Characterization of the rate-de-

pendent effects of ethmozine on con-duction, in vivo, and on the sodium

current, in vitro, in the newborn

heart, 608

Liu, Y., Blackboumn, J., Chuang, L. F., Kil-

lam, K. F., Jr. and Chuang, R. Y.:

Effects of in vivo and in vitro admin-istration of morphine sulfate upon

rhesus macaque polymorphonuclean

cell phagocytosis and chemotaxis,

533

Liu, Y. and Thurman, R. G.: Potentiation

of adniamycin toxicity by ethanol in

perfused rat liver, 651

Liver

dimethylnitrosamine-induced necrosis,

Ca�-activated DNA fragmentation

(mice), 387

diquat-induced oxidative stress, marked

interanimal differences (rats), 1003

mechanism for hepatotoxicity, nilutamide

(rats), 69

microsomal polysubstrate monooxygen-

ase, effects of intrauterine position

(rats), 32

prevention of Adniamycin toxicity,

ethanol (mats), 651

suppression of hepatic drug metabolism,

polyniboinosinic

acid:polyribocitidylic acid (rats), 381

targeted delivery, human recombinant su-

peroxide dismutase, chemical mock-fication, 971

LLC-PK1 cells, digoxin transport, humanP-glycopnotein expression, 840

Llorens, J., see St. Claim, M. B. G., 1432

Locomotion, brain dopamine systems, ge-

netic mouse model, Lesch-Nyhan

syndrome, 596

Locus coeruleus, inhibition of adenylate cy-

clase, mediation of hypnotic re-

sponse, alpha, agonist (mats), 1046

Loendens, B., Rampart, M. and Herman, A.

G.: Selective M, muscaminic receptorantagonists inhibit smooth muscle

contraction in rabbit trachea without

1992 Index 1505

increasing the release of acetylocho-

line, 773

Loh, H. H., see Roy, S., 451

Loizzo, A., see Pieretti, S., 830

Lonsberry, B. B., Czubmyt, M. P., Dubo, D.

F., Gilchrist, J. S. C., Docherty, J. C.,

Maddaford, T. G. and Pierce, G. N.:Effect of chronic administration of

verapamil on Ca� channel density in

rat tissue, 540

Loomis, C. W. and Arunachalam, K. D.:

Intrathecal St-587: Effects on noci-

ceptive reflexes and blood pressure in

the rat, 428L#{243}pez-Farr#{233},A., see Cemnadas, M. R., 1023

Losartancaptopnil and angiotensin II antagonists,

renal function, renal artery stenosis

(dogs), 422

norepinephnine overflow and antidiuresis,stimulation of renal nerves (dogs),

956

Lu, Y., France, C. P. and Woods, J. H.:Tolerance to the cataleptic effect of

the N-methyl-D-aspartate (NMDA)

receptor antagonists in pigeons:Cross-tolerance between PCP-like

compounds and competitive NMDA

antagonists, 499

Lu, Y., see Takahashi, T., 1

L#{252}cking,C. H., see Lupp, A., 717

Lungaccumulation of propranolol, physio-

chemical mechanism (sheep), 130

binding sites on membranes, leukotnienes

B4 and B5, contraction (frogs), 1111

second leukotriene receptor (humans),

800

Lung neoplasms, small cell, neunomedin B,

binding with high affinity, 311

Luong, T., see Gerstin, E. H., Jr., 910

Lupp, A., Lucking, C. H., Koch, R., Jack-isch, R. and Feuerstein, T. J.: Inhib-

itory effects of the antipankinsonian

drugs memantine and amantadine on

N-methyl-d-aspartate-evoked acetyl-

choline release in the rabbit caudate

nucleus in vitro, 717

Luteinizing hormone, acute effects of co-

caine, cocaine-dependent men, 505LY53857, serotonin-induced relaxation,

coronary artery smooth muscle

(dogs), 123

LY223982, specific inhibition, leukotniene

B4-induced neutnophil activation

(guinea pigs, humans), 1009

Lysko, K. A., see Yue, T.-L., 92Lysko, P. G., see Yue, T.-L., 92

Maayani, S., see Mahle, C. D., 1275MacGlashan, D. W., Jr., see Columbo, M.,

979

Maddaford, T. G., see Lonsbenry, B. B., 540

Madhok, T. C., see Shahabi, N. A., 876

Madhu, C., Gregus, Z. and Klaassen, C. D.:Marked interanimal differences in

susceptibility of Sprague-Dawley rats

to diquat-induced oxidative stress in

the liver: Correlation with hepatic

uptake of diquat, 1003

Maeda, N., see Matsuoka, N., 436

Magnesium

antacid and gastric mucosa interaction,“artificial stomach” model, 1206

extracellular, cardiac glycoside toxicity,myocardium (humans), 1352

Mahle, C. D., Wiener, H. L., Yocca, F. D.

and Maayani, S.: Allosteric interac-

tions between the binding sites ofreceptor agonists and guanine nu-

cleotides: A comparative study of the

5-hydnoxytryptamine,A and adeno-

sine A, receptor systems in rat hip-pocampal membranes, 1275

Maitotoxin, activator of mediator release

from basophils, increases in cytosolic

calcium, histamine release, 979

Malik, K. U., see Nebigil, C., 987

Mallett, B. E., see Jackson, W. T., 1009

Malmberg, A. B. and Yaksh, T. L.: Antino-

ciceptive actions of spinal nonsteroi-dal anti-inflammatory agents on the

formalin test in the rat, 136

Malmberg, A. B. and Yaksh, T. Y.: Isobol-

ographic and dose-response analyses

of the interaction between intrathe-

cal mu and delta agonists: Effects of

naltrindole and its benzofuran analog

(NTB), 264Mankes, R., see van den Hoeven, Th., 32

Mans, A. M., see Carlson, B. X., 1401

Marczin, N., Ryan, U. S., and Catravas, J.

D.: Methylene blue inhibits nitrova-sodilator- and endothelium-derived

relaxing factor-induced cyclic GMP

accumulation in cultured pulmonary

arterial smooth muscle cells via gen-

eration of superoxide anion, 170

Manley, R. J., see de Fiebre, N. C., 232Marone, G., see Columbo, M., 979

Marsac, J., see Devillier, P., 767

Martin, B. R., see Compton, D. R., 1118

Martin, B. R., see Thomas, B. F., 1383

Martin, G. E., see Jarvis, M. F., 253

Martinez, J. L., Jr., see Derrick, B. E., 725

Matera, M. G., see Calderaro, V., 579

Mathews, W. R., see Kerr, S. W., 285

Matsuda, Y., see Oda, S., 241Matsumura, Y., see Suzuki, Y., 956Matsuoka, N., Maeda, N., Yamazaki, M.,

Ohkubo, Y. and Yamaguchi, I.: Effect

of FR121196, a novel cognitive en-

hancer, on the memory impairment

of rats in passive avoidance and ra-

dial arm maze tasks, 436

Matthies, C., see Frei, U., 938

Mattox, S. R., see Picker, M. J., 668

Mayumi, T., see Kitanaka, J.-I., 1248

Maze, M., see Correa-Sales, C., 1046

McArdle, J. J., see Choi, J. J., 49

McGregor, D. N., see Kohlhepp, S. J., 1464

McKenna, P. J., see Yue, T.-L., 92McKinney, M., see Miller, J. H., 663

McLeskey, S. W. and Wojcik, W. J.: Pro-

pylbenzilylcholine mustard has

greater specificity for muscaninic m,

receptors than for m, receptors pres-

ent in cerebellar granule cell culture

from rat, 703

McMillian, M. K., see Suh, H. H., 527

Melanocyte-stimulating hormone, -like pep-

tides, inhibitory effect, binding of do-pamine receptor ligands (rats), 787

Melis, M. A., see Serma, M., 1360

Meller, E., Puza, T., Diamond, J., Lieu, H.-

D. and Bohmaker, K.: Comparativeeffects of receptor inactivation, 17f�-

estradiol and pertussis toxin on do-

paminergic inhibition ofprolactin se-cretion in vitro, 462

Mello, N. K., see Mendelson, J. H., 505

Meltzer, H. Y., see Yamamoto, B. K., 180

Meltzer, L. T., see Pugsley, T. A., 1147

Memantine, amantadine and, inhibitory ef-fects, NMDA-evoked acetylcholine

release in caudate nucleus (rabbits),

717

Membrane potential, myentemic neurons,

tolerance and dependence to mom-

phine (guinea pigs), 15Memo, M., see Nisoli, E., 823

Memoryimpairment, passive avoidance and radial

arm tasks, effect of FR121196 (rats),

436working and reference, NMDA receptor

antagonists and scopolamine, intra-

hippocampal injections (rats), 943Mendelson, J. H., Teoh, S. K., Mello, N. K.,

Ellingboe, J. and Rhoades, E.: Acuteeffects of cocaine on plasma adneno-

corticotropic hormone, luteinizing

hormone and prolactin levels in co-caine-dependent men, 505

Mery, P., see Beregi, J.-P., 1369Mesangial cells, glomerular, thrombin ef-

fect, prostaglandin production (rats),404

Mestre, M., see Beregi, J.-P., 1369Mesulengine, m-chlorophenylpipenazine-in-

duced neuroendocnine changes, sero-tonin receptor subtype-selective an-

tagonists (mats), 588

Methamphetamine

-induced neunotoxicity, motor impair-

ments (rats), 617

passive avoidance and radial arm tasks,

memory impairment, effect of

FR121196 (rats), 436

5-Methoxydimethyltryptamine, block of

prepulse inhibition, acoustic startle

reflex (rats), 486

ct-Methyl-D,L-p-tyrosine methylester hy-

drochlonide, induction ofopposing ef-

fects on pain, L-dopa (rats), 470

N-Methyl-D-aspartate

-activated currents, inhibition by lead,

hippocampal neurons (rats), 868antagonists, tolerance to cataleptic effects

(pigeons), 499

-evoked acetylcholine release in caudate

nucleus, inhibitory effects, meman-

tine and amantadine (rabbits), 717

-induced current, ontogeny, hippocampalneurons (rats), 859

potentiation of response, neumopeptide Y,

CA, dorsal hippocampus (rats), 1212,

1219N-Methyl-D-aspartic acid, non-NMDA re-

ceptors and, hippocampal norepi-

nephnine release (rats), 327

Methylene blue, inhibition of cyclic GMP

accumulation, superoxide anion, an-

tenial smooth muscle cells (rabbits),

170

3,4-Methylenedioxymethamphetamine, 5-HT1B agonist and, tolerance and

cross-tolerance (rats), 318

Methysergide, block of prepulse inhibition,

acoustic startle reflex (rats), 486

Micheli, D., see Giacometti, A., 1241Michelsen, P., see Bergstnand, H., 1334Microdialysis, effect of ampemozide, carrier-

mediated stniatal dopamine release

(rats), 180

1 506 Index Vol. 263

Micropuncture, amiloride-sensitive lithium

reabsorption (rats), 646

Midazolam, lack of tolerance and physical

dependence, repeated treatment, zol-

pidem (mice), 298

Mignon, M., see Vatier, J. L., 1206

Miller, J. H., Aagaard, P. J., Gibson, V. A.

and McKinney, M.: Binding andfunctional selectivity of himbacine

for cloned and neuronal muscarinic

receptors, 663

Miosis, inhibition of outflow facility, pilo-

carpine, muscarinic receptor subtype

antagonists (monkeys), 1133

Miyake, A., Yamamoto, H., Takebayashi,Y., Imai, H. and Honda, K.: Thenovel natural product YM-26567-1

[(+)-trans-4-(3- dodecanoyl-2,4,6-

trihydnoxyphenyl)-7-hydroxy-2-(4-

hydroxy- phenyl)chroman]: A com-

petitive inhibitor of group II phos-pholipase A,, 1302

Miyata, K., see Ito, H., 1127

MK-801

NMDA and non-NMDA receptors, hip-

pocampal norepinephrine release

(rats), 327

NMDA-evoked acetylcholine release in

caudate nucleus, inhibitory effects,

memantine and amantadine (rab-

bits), 717

regulation of cholecystokinin mRNA con-

tent, striatum (rats), 368

Mocchetti, I., see Ding, X.-Z., 368

Moerschbaecher, J. M., see Mosaddeghi, M.,

639

Monnet, F. P., Debonnel, G., Fournier, A.and de Montigny, C.: Neuropeptide

Y potentiates the N-methyl-D-aspar-tate response in CA, dorsal hippo-

campus. II. Involvement of a subtypeof sigma receptor, 1219

Monnet, F. P., Foumnier, A., Debonnel, G.

and de Montigny, C.: Neuropeptide

Y potentiates selectively the N-methyl-D-aspartate response in the

rat CA, dorsal hippocampus. I. In-volvement of an atypical neuropep-

tide Y receptor, 1212

Monoclonal antibodies, transferrin recep-

tom, biotin delivery to brain, covalent

conjugate of avidin, 897

Monooxygenase, hepatic microsomal poly-

substrate, effects of intrauterine p0-

sition (rats), 32

Montastruc, J. L., see Tavernier, G., 1083Moody, T. W., Staley, J., Zia, F., Coy, D.

H., and Jensen, R. T.: Neuromedin Bbinds with high affinity, elevates cy-

tosolic calcium and stimulates the

growth of small-cell lung cancer cell

lines, 311

Morel, E., see Perrault, G., 298

Morgan, K. T., see St. Claim, M. B. G., 1432

Morimoto, S., see Suzuki, Y., 956Monishita, Y., see Oda, S., 241

Morkin, E., see Pennock, G. D., 163

Moroni, F., see Skaper, S. D., 1440

Morphine

binding to interleukin 1-activated thy-

mocytes (mice), 451

inhibition of tail-flick response by etor-

phine, supraspinal � and �i opioid me-

ceptors (mice), 246

-like stimulus effects, intermediate effi-

cacy mu opioids (rats), 668

mu-mediated antinociception, modula-

tion by opioid delta-2 receptors

(mice), 147

tolerance and dependence, membrane po-

tential, myentenic neurons (guinea

pigs), 15

Morphine sulfate, polymorphonuclear cell

phagocytosis and chemotaxis (mon-

keys), 533

Mosaddeghi, M., Burke, T. F. and Moersch-

baecher, J. M.: Effects of acute ad-

ministration of alcohol on in vivo

binding of [‘H]Ro 15-1788 to mouse

brain, 639

Mosberg, H. I., see DeLander, G. E., 1097Mosberg, H. I., see Pomreca, F., 147

Mosberg, H. I., see Raffa, R. B., 1030

Mossy fiber, hippocampal, long-term poten-

tiation, /2 opioid receptors (rats), 725

Mostwin, J. L., see Seki, N., 816

Motor, impairments, methamphetamine-in-

duced neurotoxicity (rats), 617Motzo, C., see Serra, M., 1360

Moummi, C., see Gaginella, T. S., 1068

Mueller, R. A., see Simson, P. E., 1454

Mulder, A. H., see Schoffelmeen, A. N. M.,

20

Multidrug resistance, P-glycoprotein-me-

diated efflux, kinetic analysis (hu-

mans), 762

Murphy, D. L., see Aulakh, C. S., 588Muscle

bovine retractor penis, 5-nitnosothiols,

smooth muscle relaxing activity (rab-

bits), 285

bronchial, second leukotriene receptor,

lung (humans), 800

detrusor, membrane electrical activity,

pinacidil (guinea pigs), 816

Muscle, smooth

coronary artery, serotonin-induced relax-

ation (dogs), 123

inhibition of contraction, M, muscarinic

receptor antagonists (rabbits), 773

intestinal, isoprotenenol-stimulated cyclic

AMP accumulation, M2 muscaninicreceptors (rats), 221

prejunctional muscarinic receptors, deep

muscular plexus, ileum (dogs), 226

pulmonary arterial, mechanism, methyl-

ene blue action (rabbits), 170

relaxation of trachea, release of prosta-

glandin E,, neurokinin NK-i recep-

ton (rats), 767

relaxing activity, 5-nitrosothiols, bovine

retractor penis inhibitory factor (rab-

bits), 285

signal transduction mechanisms, alpha-2C and alpha-lA adrenoceptors,

prostaglandin synthesis (rabbits),

987

trachea, papaverine inhibition, voltage-

dependent Ca� current (guinea

pigs), 194

Myentenic plexus

ileum longitudinal muscle, induced ace-

tylcholine release, anatoxin-a (guinea

pigs), 997

membrane potential, tolerance and de-

pendence to morphine (guinea pigs),

15

nicotinic receptor-evoked release, acetyl-

choline and somatostatin, calcium in-

flux (guinea pigs), 1

Myers, S. L., see Pugsley, T. A., 1147

Myocardial infarction, heart failure, bano-

reflex control of heart rate, captopril

(rats), 1424

Myocandial ischemia, modulation of severity

and coronary vascular tone, endothe-

lin-1 and big endothelin-1 (rats),

1074

Myocardium

limitation of injury, cromakalim and U-

89,232, vascular vs. cardiac actions

(guinea pigs), 1261

negative inotropic response, blocking ef-

fects, Vi and V2 antagonists (dogs),

627

positive inotropic effects, RP 62719

(guinea pigs), 1369

reduction of cardiac glycoside toxicity, ex-

tracellular magnesium concentration

(humans), 1352

Myocytes

interaction of taunine, fast sodium current

(rabbits), 1233

ventricular, effect of ambasilide, plateau

currents (guinea pigs), 40

Myo-inositol, aldose reductase and, endo-

thelial cell dysfunction, elevated glu-

cose (rabbits), 153

Myosin light chain kinases, inhibitors, mod-

ulation of neutnophil superoxide gen-

eration, 1334

Nacif-Coelho, C., see Cornea-Sales, C., 1046

Nakajima, T., see Iguchi, M., 194

Nakata, N., see Sakurada, S., 793

Naloxone

dissociation constant, time dependence,

opioid delta receptors in vas defenens

(mice), 1030

-induced bradycardia, peripheral sympa-

thetic nervous system, alpha-2 ache-

noceptors (rats), 918

-insensitive receptor for jl-endorphin,

antisera characterization, U937 cells

(rabbits), 876

Naltrindole

benzofunan analog and, intrathecal mu

and delta agonists (rats), 264

Ii opioid receptors, induction, hippocam-

pal mossy fiber long-term potentia-

tion (rats), 725

Nambi, P., see Albnightson, C. R., 404Napier, T. C., see Simson, P. E., 1454

Nasjletti, A., see Yamaguchi, Y., 905

N#{228}sman, J., see Kukkonen, J., 1487

Natriuresis, renal and systemic effects, ami-

noacids (rats), 1023

Nebigil, C. and Malik, K. U.: Comparison of

signal transduction mechanisms of

alpha-2C and alpha-iA adrenergic re-

ceptor-stimulated prostaglandin syn-

thesis, 987

Negus, S. S., see Picker, M. J., 668

Neonate

heart, rate-dependent effects of ethmo-

zine, conduction (dogs), 6086-OHDA-induced lesions, regional ef-

fects, dopamine Dl receptors (rats),1454

Nephron, involved site, gentamicin-inducedhypencalciuria (rats), 293

Nephrotoxicity, determinants of in vitro in-

teraction, polyspartic acid, aminogly-

coside antibiotics, 1464

1992 Index 1507

Nervecontractile responses in blood vessels, fla-

voniod potentiation (rats), 78penivasculan, arterial dilatation and yen-

oconstniction, calcitonin gene-relatedpeptide (rats), 1226

renal, losartan, nonepinephnine overflowand antidiunesis (dogs), 956

Neunoblastomablock of voltage-gated potassium cur-

rents, U-5449A (mice), 207

characterization of YMO6O, nodose gan-glion (rabbits), 1127

muscaninic receptor subtypes, 1487Neurokinin-1, receptors, venous response,

penivascular nerve stimulation (rats),

1226Neunomedin B, binding with high affinity,

growth, small cell lung cancer cell

lines, 311

Neuromuscular junction, mammalian, role

ofprotein kinase C, short-term trans-mission, 1269

Neurones, basolatenal and central amygda-

bid, differential actions, corticotro-pin releasing factor (rats), 846

Neurons

active ion transport in small intestine,nonepinephrine and alpha-2 adre-noceptors (pigs), 510

enteric, oxidant-evoked release of acetyl-choline, colon (rats), 1068

hippocampalinhibition of NMDA-activated cur-

rents, lead (rats), 868

ontogeny, NMDA-induced current(rats), 859

muscarinic receptors, binding and func-tional selectivity, himbacine, 663

myentemic, membrane potential, tolerance

to morphine (guinea pigs), 15

Neunopeptide Yinhibition of forskolin-stimulated aden-

ylate cyclase, bovine adrenal chro-

maffin cells, 1479potentiation ofNMDA response, CA, don-

sal hippocampus (rats), 1212, 1219Neurotoxicity

methamphetamine-induced, motor im-pairments (rats), 617

2,4,5-tnihydroxyphenylalanine, protectiveeffects, ganglioside GM1, 1440

Neurotoxinscooperative modulation, voltage-depend-

ent sodium channels, bovine adrenal

medullary cells, 1347

induction of exocytosis by pardaxin, bo-vine adrenal medullamy chromaffincells, 1317

Neurotnansmission, adrenengic, potassiumchannel openers, brain cortical slices(rats), 1293

Neurotmansmitter

adenylate cyclase-coupled opioid receptor

complex, opioid receptor antagonists

(rats), 20noradnenergic hyperactivity, fetal cocaine

exposure, brain (rats), 413Neutnophils

block of recruitment, inhibition of me-versed passive Arthus reaction, NPC

15669 (rats), 933leukotriene B4-induced activation, spe-

cific inhibition, LY223982 (guineapigs, humans), 1009

superoxide generation by kinase inhibi-

tons, 1334

Nickel, B., see Swedberg, M. D. B., 1015Niddam, R., see Angel, I., 1327

Nifedipine

hemodynamic and sedative effects, dex-

medetomidine (dogs), 690potency, semotonin-exposed coronary and

internal mammary arteries (hu-mans), 112

NIH-3T3 cells, acidic fibroblast growth fac-

ton binding, FGF-flg, hepanin/pertus-sis toxin/guanine nucleotides, 253

Nilutamide, mechanism for hepatotoxicity

(mats), 69

Nishida, A., see Ito, H., 1127

Nishikawa, M., see Fujita, T., 971

Nishiura, A., see Yamamoto, A., 25Nisoldipine, potency, serotonin-exposed

coronary and internal mammary am-

teries (humans), 112

Nisoli, E., Tonello, C., Memo, M. and Car-

ruba, M. 0.: Biochemical and func-tional identification of a novel dopa-

mine receptor subtype in rat brownadipose tissue. Its role in modulating

sympathetic stimulation-induced

thermogenesis, 823

Nitric oxide, pharmacological activity of ni-

troxyl (rabbits), 546Nitrosothiols, mechanism of methylene blue

action, pulmonary arterial smooth

muscle (rabbits), 170

5-Nitrosothiols, smooth muscle relaxing ac-

tivity, bovine retractor penis inhibi-

tory factor (rabbits), 285

Nitroxyl, pharmacological activity (rabbits),

546

Nociception, reflexes and blood pressure,

intrathecal St-587 (rats), 428

Nonstenoidal anti-inflammatory agents,

spinal, antinociceptive actions, for-

malin test (rats), 136Noradnenaline

adrenergic and angiotensinergic recep-tons, angiotensin Il-induced vaso-

pressin release, paraventricular flu-

cleus (rats), 1253

adrenergic neumotransmission and MRb+

efflux, potassium channel openers,

brain cortical slices (rats), 1293

basolateral and central amygdaloid neu-

nones, differential actions, corticotro-

pin releasing factor (mats), 846

Nor-binaltorphimine, �i opioid receptors, in-

duction, hippocampal mossy fiber

long-term potentiation (mats), 725Norel, X., see Labat, C., 800Norepinephnine

atpha-2 adrenoceptors and, active iontransport, small intestine (pigs), 510

endogenous, NMDA receptor stimulation,hypothalamus (rats), 61

hippocampal release, NMDA and non-

NMDA receptors (rats), 327noradnenergic hyperactivity, fetal cocaine

exposure, brain (rats), 413overflow and antidiuresis, losartan, stim-

ulation of renal nerves (dogs), 956renal spillover, quinpirole, renal sympa-

thetic nerve activity (rabbits), 806

vasoconstnictor and vasodilator effects,senotonin, kidney (rabbits), 928

Norman, N. R., see Toombs, C. F., 1261Norman, P., see Labat, C., 800

Noronha-Blob, L., see Bunch, R. M., 933NPC 15669, inhibition of reversed passive

Arthus reaction, block of neutrophil

recruitment (rats), 933

Nucleus accumbens, acetylcholine release

and cocaine, dopamine uptake block-ade, local anesthetic properties (rats),757

Nybom, A., see Bengstrand, H., 1334

Nyby, M. D., see Berger, M. E., 78

O’Callaghan, J. P., see St. Clam, M. B. G.,

1432

Oda, S., Sano, T., Monishita, Y., and Mat-suda, Y.: Pharmacological profile of

HS-142-1, a novel nonpeptide atnialnatniunetic peptide (ANP) antagonistof microbial origin. II. Restoration byHS-i42-1 ofANP-induced inhibition

of aldostenone production in adrenalglomerulosa cells, 241

Ogawa, N., see Watanabe, H., 1036

Ogletnee, M. L., O’Keefe, E. H., Durham, S.K., Rubin, B., and Abeng, G.: Gastro-protective effects of thromboxane me-ceptor antagonists, 374

6-OHDA, regulation of cholecystokininmRNA content, stniatum (rats), 368

Ohdo, S., see Watanabe, H., 1036

8-OHDPAT, block of prepulse inhibition,acoustic startle reflex (rats), 486

Ohkubo, Y., see Matsuoka, N., 436Ohno, M., Yamamoto, T. and Watanabe, S.:

Effects of intrahippocampal injec-

tions of N-methyl-D-aspartate recep-

ton antagonists and scopolamine on

working and reference memory as-sessed in rats by a three-panel run-

way task, 943Ojala, P., see Kukkonen, J., 1487Okada, K., see Ishikawa, S., 1050Okamoto, T., see Sakai, H., 381Okamuna, N., see Tanigawara, Y., 840O’Keefe, E. H., see Ogletree, M. L., 374Olfactory marker protein, olfactory toxicity

of �,fl’-iminodipropionitnile (rats),

1432Ookhtens, M., see Kannan, R., 964OPC-21268, OPC-31260 and, blocking ef-

fects, negative inotropic response to

vasopnessin (dogs), 627

Opioids

mu, intermediate efficacy (rats), 668spinal on supraspinal receptor-selective

agonists, adenosine, antinociception

(mice), 1097

Ortiz, J. L., see Labat, C., 800Owyang, C., see Takahashi, T., 1Oxidative stress, mechanism for hepato-

toxicity, nilutamide (rats), 69Oxygen, diquat-induced oxidative stress,

marked intemanimal differences(rats), 1003

Paalzow, G. H. M.: L-Dopa induces opposingeffects on pain in intact rats: (-)-

Sulpinide, SCH 23390 or a-methyl-

DL-p-tyrosine methylester hydro-

chloride reveals profound hypenalge-sia in large antinociceptive doses, 470

Pain, induction of opposing effects, L-dopa(mats),470

Papavenine, inhibition of voltage-dependent

Ca� current, smooth muscle cells,trachea (guinea pigs), 194

Paraventricular nucleus, admenergic and an-

I 508 Index Vol. 263

giotensinergic receptors, angiotensin

Il-induced vasopressin release (rats),1253

Pardaxin, induction of exocytosis, bovineadrenal medullany chromaffin cells,1317

Pandnidge, W. M., see Yoshikawa, T., 897Parkinson’s disease

clearance and diffusion, locally applieddopamine, stniatum (rats), 1285

motor impairments, methamphetamine-

induced neunotoxicity (rats), 617NMDA-evoked acetylcholine release in

caudate nucleus, inhibitory effects,memantine and amantadine (nab-

bits),717

2,4,5-trihydnoxyphenylalanine neurotox-icity, protective effects, ganglioside

GM1, 1440

Panotid gland, acinar cells, atypical alpha-iadnenengic receptors (rats), 1062

Pannillo, C., see Calderano, V., 579Patch clamp, intearction of taunine, fast

sodium current, myocytes (rabbits),

1233Payne, N. A. and Gerber, J. G.: Differential

effects of somatostatin and prosta-

glandins on gastric histamine releaseto pentagastnin, 520

PD 118717, pharmacological characteriza-

tion (mice), 1147

Peele, D. B., see St. Clam, M. B. G., 1432

Pennock, G. D., Raya, T. E., Bahl, J. J.,Goldman, S., and Morkin, E.: Cardiaceffects of 3,5-diiodothyropmopionic

acid, a thyroid hormone analog withinotnopic selectivity, 163

Pentamidine, interactions between zinc and

spermidine, NMDA receptor com-plex, 632

Pentobarbitalactivity, effects of social isolation, brain

(mice, rats), 1036

-enhanced flunitrazepam binding, brain(rats), 1401

other alcohols and, chronic ethanol treat-

ment, development of cross-tolerance(mice), 480

Peny, B., see Benavides, J., 884Peptides, complementary to fl-endorphin,

naloxone-insensitive receptor, anti-

sera and U937 cells (rabbits), 876Peptidyl prolyl cis-trans isomerase, modu-

lation of neutrophil superoxide gen-

eration, kinase inhibitors, 1334Perfloxacin, ciprofloxacin and, cenebrospi-

nal fluid transport and disposition

(rats), 1140

Penoxisome, induction of enzyme activities,

di-(2-ethylhexyl)phthalate, pamathy-roid replants (rats), 1105

Pennault, G., Morel, E., Sanger, D. J., andZivkovic, B.: Lack of tolerance andphysical dependence upon repeatedtreatment with the novel hypnoticzolpidem, 298

Pertussis toxin

acidic fibroblast growth factor binding,FGF-flg, NIH-3T3 cells, 253

17/3-estradiol and, receptor inactivation,dopaminengic inhibition of pmolactin

secretion (rats), 462

inhibition of forskolin-stimulated aden-

ylate cyclase, neuropeptide Y, bovineadrenal chromaffin cells, 1479

Pessayre D., see Fau, D., 69

Peterson, V. A., see Stmobl, J. S., 186

P-glycopmoteindigoxin transport, LLC-PK1 cells, 840

-mediated doxorubicin efflux, kineticanalysis (humans), 762

pH, antacid and gastric mucosa interaction,“artificial stomach” model, 1206

Phagocytosis, polymorphonuclean cells,

morphine sulfate effects (monkeys),533

Phencyclidine, tolerance to cataleptic effect,N-methyl-D-aspartate receptor an-

tagonists (pigeons), 499Phenethylamine, YM617, alpha-i adreno-

ceptor radioligand (rats), 201

Phenobanbital, aromatic anticonvulsant-in-duced hypersensitivity reactions, hu-man anti-cytochrome P450 antibod-

ies, 3602-Phenylaminoadenosine, labeling of novel

adenosine receptor in brain (rats),552

Phenylephrine, vasoconstricton and vasodi-laton effects, serotonin, kidney (nab-bits), 928

Phipps, D. J., see Garland, H. 0., 293

Phorbol ester, role of protein kinase C,short-term transmission, mamma-

han neuromuscular junction, 1269Phosphodiesterase

-cyclic AMP, inhibition by R 80122, heart

(humans), 6

cyclic AMP-specific, stimulation of beta

admenoceptors, U937 cells, 1195

papavenine inhibition, voltage-dependentCa� current, tracheal smooth muscle(guinea pigs), 194

Phosphoinositide, hydrolysis, extracellular

ATP, glioma C6 cells (rats), 1248Phospholipase A,

group II, competitive inhibitor, YM-26567-1 (rabbits), 1302

suppression of chloride secretion, anti-

flammins, distal colonic mucosa (rab-

bits), 579

Phospholipids, platelet-activating factor,

arachidonic acid release, fetal brain(rats), 562

Phthalates, di-(2-ethylhexyl)phthalate, in-

duction of peroxisomal enzyme activ-ities, panathyroid replants (rats),

1105

Physostigmine, passive avoidance and ma-

dial arm tasks, memory impairment,effect of FR121196 (rats), 436

Picker, M. J., Craft, R. M., Negus, S. S.,Powell, K. R., Mattox, S. R., Jones,S. R., Hangrove, B. K. and Dykstna,L. A.: Intermediate efficacy mu

opioids: Examination of their mom-

phine-like stimulus effects and re-sponse rate-decreasing effects in

morphine-tolerant rats, 668

Pickoff, A. S., see Liu, W., 608Pierce, G. N., see Lonsberry, B. B., 540Pieretti, S., di Giannuario, A., Loizzo, A.,

Sagnatella, S., Scotti de Canolis, A.,

Capasso, A. and Sorrentino, L.: Dex-amethasone prevents epileptiformactivity induced by morphine in in

vivo and in vitro experiments, 830Pilocarpine, accommodative and miotic ne-

sponses, inhibition of outflow facil-

ity, muscaminic subtype antagonists(monkeys), 1133

Pimoule, C., see Angel, I., 1327

Pimozide, inhibition, tamoxifen-resistantbreast cancer cell growth (humans),

186

Pinacidil

adrenergic neurotnansmission, MRb+ ef-

flux, brain cortical slices (rats), 1293

membrane electrical activity, detnusormuscle (guinea pigs), 816

Piperazinyl benzopyranone, dopamine au-

toreceptor agonist, pharmacological

characterization, PD 118717 (mice),

1147

Pirenzepine, muscarinic cholinergic recep-tom binding, quantitative autoradiog-

raphy, brain (rats), 1391

Pittaluga, A. and Raiteni, M.: N-methyl-D-

aspartic acid (NMDA) and non-

NMDA receptors regulating hippo-campal norepinephnine release. III.Changes in the NMDA receptor com-plex induced by their functional co-operation, 327

Platelet-activating factor, stimulation of an-

achidonic acid release, thromboxaneB, production, fetal brain (rats), 562

Poinien, J.-M., see Funck-Brentano, C., 780Poisnen, A. M., see Suh, H. H., 527

Poly(ADP-ribose)polymerase, dimethylni-trosamine-induced hepatic necrosis,

Ca�-activated DNA fragmentation

(mice), 387Polyaspartic acid, aminoglycoside antibiot-

ics and, determinants, in vitro inter-

action, 1464Polymorphonuclear cells, phagocytosis and

chemotaxis, morphine sulfate effects

(monkeys), 533

Polyniboinosinic acid:polynibocitidylic acid,suppression of hepatic drug metabo-lism (rats), 381

Porreca, F., see DeLander, G. E., 1097Porreca, F., see Raffa, R. B., 1030

Porreca, F., see Weber, S. J., 1308Porreca, F., Takemoni, A. E., Sultana, M.,

Portoghese, P. 5., Bowen, W. D., and

Mosberg, H. I.: Modulation of mu-

mediated antinociception in the

mouse involves opioid delta-2 recep-toms, 147

Porter, J. E., Dowd, F. J. and Abel, P. W.:Atypical alpha- 1 adnenergic receptors

on the rat parotid gland acinar cell,

1062

Portoghese, P. 5., see Pomreca, F., 147

Portoghese, P. S., see Schoffelmeer, A. N.

M., 20Potassium, MRb� and 45Ca� efflux, effects

of tacnine on insulin secretion, pan-creatic islets (rats), 494

Potassium channel

blocker RP 62719, positive inotropic ef-

fects, myocardium (guinea pigs), 1369

labeling of novel adenosine receptor, [‘H]

2-phenylaminoadenosine (rats), 552

openers, dilation, large epicardial coro-

nary arteries (dogs), 1091

openers cromakalim and U-89,232, limi-

tation, myocardial injury (guineapigs), 1261

Potassium currentplateau currents in ventricular myocytes,

effect of ambasilide (guinea pigs), 40

1992 Index 1509

voltage-gated, block by U-5449A, neuro-

blastoma cells (mice), 207

Powell, K. R., see Picker, M. J., 668Prolactin

acute effects of cocaine, cocaine-depend-

ent men, 505

dopaminergic inhibition of secretion, me-

ceptor inactivation, 17f3-estradiol

and pertussis toxin (rats), 462Propranolol

block ofprepulse inhibition, acoustic star-

tle reflex (rats), 486

m-chlorophenylpiperazine-induced neu-

roendocrine changes, serotonin me-ceptor subtype-selective antagonists(rats), 588

pulmonary accumulation, physiochemical

mechanism (sheep), 130

Propylbenzilylcholine mustard, specificity

for muscarinic m, receptors, cerebel-lan granule cell culture (rats), 703

Prostaglandin E,anachidonic acid and, prolonged stimula-

tion, adrenal chromaffin cells (cat-

tle), 527

tracheal relaxation, activation, epithelial

neurokinin NK-i receptor (rats), 767

Prostaglandin H,, receptors, renal hemody-namic response to blockade, angio-

tensin II (rats), 905

Prostaglandins

platelet-activating factor, arachidonic

acid release, fetal brain (rats), 562production, thrombin effect, glomerular

mesangial cells (rats), 404somatostatin and, differential effects, gas-

tric histamine release to pantagastnin

(dogs), 520

suppression of chloride secretion, anti-flammins, distal colonic mucosa (rab-bits), 579

synthesis, alpha-2C and alpha-iA adne-noceptors, signal transduction mech-

anisms (rabbits), 987

Protein kinase Cinhibitors, modulation, neutrophil super-

oxide generation, 1334role in short-term transmission, mam-

malian neuromuscular junction, 1269

Proximal tubular cells, organic cation trans-port, cationic drug interactions

(rats), 445

Psychotherapeutic agents, D-16949, dis-

criminative effects (rats), 1015

Puberty, effects of alcohol, hypothalamic-

pituitary-gonadal axis, development

(rats), 1056

Pugsley, T. A., Christofferson, C. L., Corbin,A., DeWald, H. A., Demattos, S.,Meltzer, L. T., Myers, S. L., Shih, Y.-

H., Whetzel, S. Z., Wiley, J. N., Wise,L. D. and Heffner, T. G.: Phammaco-logical characterization of PD

118717, a putative piperazinyl ben-

zopynanone dopamine autoreceptonagonist, 1147

Puza, T., see Meller, E., 462

Qadni, F., see Veltmar, A., 1253

Quartaroli, M., see Giacometti, A., 1241

Quinidine, digoxin transport, human P-gly-coprotein expression, LLC-PK1 cells,840

Quinolones, ciprofloxacin and perfioxacin,cerebrospinal fluid transport and dis-

position (rats), 1140

Quinpirole6-OHDA-induced lesions, regional ef-

fects, dopamine Dl receptors (rats),

1454renal sympathetic nerve activity, renal

norepinephnine spillover (rabbits),

806

Quisqualate, neuropeptide Y, potentiation

of NMDA response, CA, dorsal hip-

pocampus (rats), 1212, 1219

R 80122, inhibition ofcyclic AMP-phospho-diesterases, heart (humans), 6

Rabin, R. A., see Winter, J. C., 682Radioligands, YM617, alpha-i adrenoceptor

(rats), 201

Raffa, R. B., Wild, K. D., Mosberg, H. I.and Porreca, F.: Thermodynamicanalysis of the temperature depend-ence of the dissociation constant of

naloxone at opioid delta receptors in

the mouse isolated vas deferens, 1030Rainnie, D. G., Fernhout, B. J. H. and Shin-

nick-Gallagher, P.: Differential ac-tions of corticotropin releasing factor

on basolateral and central amygda-

bid neurones, in vitro, 846

Raiteni, M., see Pittaluga, A., 327Rampart, M., see Loenders, B., 773

Ranitidine, gastroprotective effects, throm-

boxane receptor antagonists (rats),374

Rascher, W., see Veltmar, A., 1253

Ravera, M. W., see Jarvis, M. F., 253Ray, S. D., Sorge, C. L., Kamendulis, L. M.,

and Corcoran G. B.: Ca�-activatedDNA fragmentation and dimethyl-

nitrosamine-induced hepatic necro-sis: Effects of Ca�-endonuclease andpoly(ADP-ribose) polymerase inhib-itors in mice, 387

Raya, T. E., see Deck, C. C., 1424

Raya, T. E., see Pennock, G. D., 163

Raybould, D., see Bloor, B. C., 690

Reaves, C. B., see Gordon, R. K., 997

Receptorsadenosine, labeling by 2-phenylaminoad-

enosine, brain (rats), 552

adenosine A1, experimental paradigm, in-

teractions in vivo, 657

adrenergic, hyperactivity, fetal cocaine

exposure (rats), 413

adrenergic and angiotensinergic, paraven-

tnicular nucleus, angiotensin Il-in-

duced vasopressin release (rats), 1253r-aminobutynic acidA complex, pharma-

cology, abecarnil (rats), 1360

benzodiazepine, acute alcohol administra-tion, Ro 15-1788 binding to brain

(mice), 639bradykinin, tracheal, effect of Hoe 140

(guinea pigs), 1377Ca� channel density in tissue, chronic

verapamil administration (rats), 540

dopamineautoradiographic localization, epicar-

dial arteries (humans), 1447inhibitory effect, adrenocorticotnopin/

melanocyte-stimulating hormone-like peptides (rats), 787

preclinical behavioral effects, DuP 734(mice), 1159

subtype in brown adipose tissue,thermogenesis (rats), 823

dopamine Dl, regional effects, 6-OHDA-

induced lesions (rats), 1454

dopamine D2, renal sympathetic nerveactivity, quinpirole (rabbits), 806

epithelial neurokinin NK-i, relaxation oftrachea, release of prostaglandin E,

(rats), 767

GABAA, general anesthetics, Xenopus oo-cytes, 569

histamine H,, agonist Imetit (rats, mice),

3045-HT,, electrophysiological and neuro-

pharmacological profiles (guineapigs), 1167

5-HT,, antagonist YMO6O, nodose gan-

glion and N1E-115 neumoblastoma

cells (rabbits), 11275-HT1A

agonists, block of prepulse inhibition ofacoustic startle reflex (rats), 486

hyperpolarization, CAl and CA3 hip-pocampal pyramidal cells (rats), 350

yohimbine as a serotonergic agent

(rats), 682

5-HT1BD-16949, discriminative effects (rats),

10153,4-methylenedioxymethamphetamine

and, tolerance and cross-tolerance(rats), 318

5-HT1A and adenosine A1, allosteric inter-

actions, hippocampal membranes

(rats),12755-HT1� and 5-HT,, discriminative stimu-

lus, clozapine (pigeons), 276inactivation, 17$-estradiol and pertussis

toxin, dopaminergic inhibition ofprolactin secretion (rats), 462

leukotriene, lung (humans), 800

leukotniene B4 and B5, lung membranes,contraction (frogs), 1111

N-methyl-D-aspartate

antagonists, scopolamine and memory

(rats), 943

antagonists, tolerance to cataleptic ef-

fect (pigeons), 499interactions between zinc and spermi-

dine, 632

release of endogenous norepinephrine,hypothalamus (rats), 61

muscarinicantagonists, inhibition of pilocampine

responses (monkeys), 1133binding and functional selectivity, him-

bacine, 663subytpes, human neuroblastoma cell

lines, 1487muscaninic cholinergic, quantitative au-

toradiography, brain (rats), 1391muscarinic M,

G protein coupling, hepanin/dextran/trypan blue (rats), 910

isopnotemenol-stimulated cyclic AMPaccumulation, intestinal smoothmuscle (rats), 221

propylbenzilylcholine mustard, cerebel-lan granule cell culture (rats), 703

muscaninic M,, antagonists, inhibition ofsmooth muscle contraction (rabbits),773

neunokinin-1, venous response, penivas-

cular nerve stimulation (rats), 1226neuromedin B, growth, small cell lung

cancer cell lines, 311neuropeptide Y, NMDA response, CA,

dorsal hippocampus (rats), 1212

nicotinic, acetylcholine and somatostatin

1510 Index Vol. 263

release, myenteric plexus (guineapigs), 1

non-NMDA, NMDA and, hippocampal

norepinephrine release (rats), 327opioid

antagonists, adenylate cyclase-coupled

opioid receptor complex in brain

(rats), 20

initiation of vomiting, role of adrener-

gic receptors (dogs), 395

morphine binding, interleukin 1-acti-vated thymocytes (mice), 451

opioid � and �i, inhibition of tail-flick re-

sponse, etorphine (mice), 246

opioid delta, dissociation constant of nal-

oxone, vas deferens (mice), 1030opioid delta-2, modulation, mu-mediated

antinociception (mice), 147

opioid mu

hemodynamic effects, GI 87084B(dogs), 84

induction, hippocampal mossy fiber

long-term potentiation (rats), 725

intermediate efficacy (rats), 668

opioid mu and delta

agonists, naltrindole and benzofurananalog (rats), 264

f3-endorphin effects, G-protein activity,

99

prejunctional muscarinic, deep muscularplexus, ileum (dogs), 226

purinergic P,, extracellular ATP-stimu-

lated phosphoinositide hydrolysis,glioma C6 cells (rats), 1248

serotonergic, relaxation, coronary arterysmooth muscle (dogs), 123

serotonin, subtype-selective antagonists,

m-chlorophenylpiperazine-induced

neuroendocrine changes (rats), 588

sigma, receptor binding profile, DuP 734

(guinea pigs), 1175spinal or supraspinal, opioid agonists,

adenosine and antinociception(mice), 1097

thromboxane, antagonists, gastroprotec-

tive effects (rats), 374

thromboxane A, and prostaglandin H,,

renal hemodynamic response to

blockade, angiotensin II (rats), 905

transferrin, biotin delivery to brain, co-valent conjugate of avidin, 897

Rectum, permeability, mechanistic study on

enhancement, insulin (rabbits), 25Redox cycling, mechanism for hepatotoxic-

ity, nilutamide (rats), 69

Reflexes, nociceptive, intrathecal St-587

(rats), 428

Regoli, D., see Claing, A., 1226Regoli, D., see Devillier, P., 767Reichlin, S., see Szabo, S., 752Reid, K., see Cornea-Sales, C., 1046

Ren, L.-M., see Furukawa, Y., 627

Reserpine, block of prepulse inhibition,acoustic startle reflex (rats), 486

Reynolds, I. J.: Interactions between zincand spermidine on the N-methyl-D-

aspartate receptor complex: Clues to

the mechanism of action of 1,10-

bis(guanidino)decane and pentami-dine, 632

Rhoades, E., see Mendelson, J. H., 505

Ricci, A., see Amenta, F., 1447

Richard, V., see Drieu la Rochelle, C., 1091

Riesco, A., see Cernadas, M. R., 1023

Rigdon, G. C. and Weatherspoon, J. K.: 5-

Hydroxytryptamine,� receptor ago-

nists block prepulse inhibition of

acoustic startle reflex, 486

Riley, R. J., see Leeder, J. S., 360Ritanserin

block ofprepulse inhibition, acoustic star-

tle reflex (rats), 486

m-chlorophenylpiperazine-induced neu-roendocrine changes, serotonin re-

ceptor subtype-selective antagonists

(rats), 588

RNA, messenger

cholecystokinin, regulation, striatum

(rats), 368

polyniboinosinic acid:polyribocitidylicacid, suppression, hepatic drug me-tabolism (rats), 381

Ro 15-1788, binding to brain, acute alcohol

administration (mice), 639Ro 16-6028, pharmacology of r-aminobu-

tynic acidA receptor complex, abecar-nil (rats), 1360

Robbins, J. D., see Appel, N. M., 1415

Rodriguez, S. B., see Derrick, B. E., 725

Rohrbach, K. W., see Cook, L., 1159

Roman, R. J., see Yamaguchi, Y., 905

Rominger, D., see Culp, S. G., 1175

Roque, C., see Boulenc, X., 1471

Rossi, F., see Calderaro, V., 579

Rossodivita, A., see Amenta, F., 1447

Rouleau, A., see Garbarg, M., 304

Roupie, E., see Dnieu la Rochelle, C., 1091

Roy, S., Ge, B.-L., Loh, H. H. and Lee, N.

M.: Characterization of [H’]mor-phine binding to interleukin-1-acti-vated thymocytes, 451

RP 62719, positive inotnopic effects, myo-cardium (guinea pigs), 1369

RU24969, 3,4-methylenedioxymethamphe-

tamine and 5-HT1B, tolerance and

cross-tolerance (rats), 318

Rubidium-86efflux from pancreatic islets, effects of

tacrine, insulin secretion (rats), 494

efflux in brain cortical slices, diazoxide,

cromakalim and pinacidil (rats), 1293

Rubin, B., see Ogletree, M. L., 374

Ruffolo, R. R., see Brooks, D. P., 422

Russel, F. G. M., see Boom, S. P. A., 445

Ryan, U. S., see Marczin, N., 170

Ryanodine, intracellular calcium pool, argi-nine vasopressin-induced cAMP pro-duction, renal papillary collecting tu-

bule cells (rats), 1050

Saeki, K., see Hata, F., 214Sagratella, S., see Pieretti, S., 830

Saito, T., see Ishikawa, S., 1050

Sakai, H., Okamoto, T., and Kikkawa, Y.:

Suppression of hepatic drug metabo-

lism by the interferon inducer, poly-

riboinosinic acid: Polynibocitidylicacid, 381

Sakurada, S., Chaki, K., Watanabe, H.,

Nakata, N., Sakurada, T., Kisara, K.

and Suzuki, K.: Antinociceptive

mechanisms of [D-Arg’]-dermorphin

tripeptide analogs, 793

Sakurada, T., see Sakurada, S., 793

Salbutamol, cyclic AMP-specific phospho-

diesterase activity, stimulation of

beta adrenoceptors, U937 cells, 1195

Salivary glands, parotid gland acinar cell,atypical alpha- 1 adrenregic receptors

(rats), 1062

Salomone, S., see Godfraind, T., 112

Sanger, D. J., see Perrault, G., 298Sanna, E., see Serra, M., 1360

Sano, T., see Oda, S., 241Sarma, J. S. M., see Zhang, Z.-H., 40

Sarna, S. K., see Lang, I. M., 395

Sawaki, S., see Furukawa, Y., 627

Scatton, B., see Benavides, J., 884

SCH 23390, induction of opposing effects

on pain, L-dopa (rats), 470

Schanne, 0. F. and Dumaine, R.: Interac-

tion of taurine with the fast sodium

current in isolated rabbit myocytes,1233

Schiavo, N., see Skaper, S. D., 1440

Schindler, R., see Frei, U., 938

Schizophrenia

discriminative stimulus of clozapine, 5-HT1� and 5-HT, (pigeons), 276

electrophysiological and neuropharmacol-ogicalprofiles, DuP 734 (guinea pigs),1167

preclinical behavioral effects, DuP 734(mice), 1159

receptor binding profile, DuP 734, brain(guinea pigs), 1175

Schmidt, W. K., see Tam, S. W., 1167

Schoemaker, H., see Angel, I., 1327

Schoffelmeer, A. N. M., De Vnies, T. J.,Hogenboom, F., Hruby, V. J., Por-toghese, P. 5., and Mulder, A. H.:Opioid receptor antagonists discrim-

mate between presynaptic mu and

delta receptors and the adenylate cy-

clase-coupled opioid receptor corn-

plex in the brain, 20

Schuster, S. V., see James, M. K., 84

Schwartz, J. C., see Garbarg, M., 304

Schwinger, R. H. G., B#{246}hm,M., Uhlmann,R., La Ros#{233}e,K., Koch, A. and Erd-

mann, E.: Increase of the extracellu-

lar magnesium concentration reduces

cardiac glycoside toxicity in the hu-

man myocardium, 1352Scopolamine

muscaninic cholinergic receptor binding,

quantitative autoradiography, brain

(rats), 1391

working and reference memory, NMDA

receptor antagonists, intrahippocam-pal injections (rats), 943

Scorpion toxin, cooperative modulation,

voltage-dependent sodium channels,bovine adrenal medullary cells, 1363

Scotti de Carolis, A., see Pieretti, S., 830

Seamon, K. B., see Appel, N. M., 1415

Sedative, -hypnotic drugs, lipid solubility,

long- and short-sleep mice, 232Seidler, F. J. and Slotkin, T. A.: Fetal co-

caine exposure causes persistent nor-adrenengic hyperactivity in rat brainregions: Effects on neurotnansmitterturnover and receptors, 413

Seizures, pharmacology of r-aminobutyricacidA receptor complex, abecamnil

(rats), 1360

Seki, N., Kanim, 0. M. A. and Mostwin, J.

L.: Effect of pinacidil on the mem-

brane electrical activity of guinea pigdetrusor muscle, 816

Selley, D. E. and Bidlack, J. M.: Effects of�3-endorphin on mu and delta opioid

receptor-coupled G-protein activity:

Low-Km GTPase studies, 99

Serotonincomparison of 5-HT1A-mediated hyper-

1992 Index 1511

polarization, CAl and CA3 hippo-campal pyramidal cells (rats), 350

-exposed coronary and internal mammaryarteries, potency, selective L-calcium

channel inhibitors (humans), 112flavonoid potentiation, contractile re-

sponses, blood vessels (rats), 78-induced relaxation, coronary artery

smooth muscle (dogs), 1233,4-methylenedioxymethamphetamine

and 5-HTIB, tolerance and cross-tol-erance (rats), 318

pharmacological characterization of PD118717 (mice), 1147

receptor subtype-selective antagonists,m-chlorophenylpipenazine-inducedneuroendocnine changes (rats), 588

vasoconstrictor and vasodilator effects,kidney (rabbits), 928

Serra, M., Foddi, M. C., Ghiani, C. A., Melis,M. A., Motzo, C., Concas, A., Sanna,E. and Biggio, G.: Pharmacology ofr-aminobutynic acidA receptor com-plex after the in vivo administrationof anxioselective and anticonvulsantf3-carboline derivative abecarnil, 1360

Sevnin, M., see Angel, I., 1327

Sex differences, effects of intrauterine p0-

sition, hepatic microsomal polysub-strate monooxygenase (rats), 32

Sezaki, H., see Fujita, T., 971Shaffen, J. E., see James, M. K., 84Shafik, E., see Choi, J. J., 49Shahabi, N. A., Bost, K. L., Madhok, T. C.

and Sharp, B. M.: Characterizationof antisera to the naloxone-insensi-tive receptor for fl-endonphin on

U937 cells generated by using thecomplementary peptide strategy, 876

Shannon, H. E., see Swedberg, M. D. B.,1015

Sharp, B. M., see Shahabi, N. A., 876Shebuski, R. J., see Toombs, C. F., 1261Shelton-James, D., see Turner, J. T., 708Sherwin, J. R., see Considine, R. V., 1269Shih, Y.-H., see Pugsley, T. A., 1147Shimada, F., see Takata, Y., 1293Shinnick-Gallagher, P., see Rainnie, D. G.,

846Shurtliff, M., see Bloom, B. C., 690Sills, M. A., see Cornfield, L. J., 552Simon, T., see Funck-Brentano, C., 780

Simpson, L. L., see Considine, R. V., 1269Simson, P. E., Johnson, K. B., Jurevics, H.

A., Criswell, H. E., Napien, T. C.,Duncan, G. E., Mueller, R. A. andBreese, G. R.: Augmented sensitivityof D1-dopamine receptors in lateralbut not medial stniatum after 6-hy-droxydopamine-induced lesions inthe neonatal rat, 1454

Singh, B. N., see Zhang, Z.-H., 40

Skaper, S. D., Facci, L., Schiavo, N., Van-tini, G., Moroni, F., Dal Toso, R. andLeon, A.: Characterization of 2,4,5-

tnihydroxyphenylalanine neunotoxic-ity in vitro and protective effects ofganglioside GM1: Implications forParkinson’s disease, 1440

SK&F 10047, tolerance to cataleptic effect,

N-methyl-D-aspartate receptor an-

tagonists (pigeons), 499SK&F 38393, 6-OHDA-induced lesions, me-

gional effects, dopamine Dl receptors(rats), 1454

SK&F 108566, captopril and EXP3174,renal function, renal artery stenosis

(dogs), 422

SL 84.0418, alpha-2 adrenoceptor antago-nist, pharmacological profile, 1327

Slavik, K. J. and Szilagyi, J. E.: Naloxone-induced bradycardia in pithed rats:Evidence for an interaction with theperipheral sympathetic nervous sys-tem and alpha-2 adrenoceptors, 918

Sleep, hypothemmic and hypnotic responses,lipid solubility, sedative-hypnoticdrugs (mice), 232

Sleph, P. G., see Grover, G. J., 1074

Slotking, T. A., see Seidler, F. J., 413

Sodium, mu and delta opioid receptor-cou-

pling, f�-endorphin effects, G-proteinactivity, 99

Sodium channel, voltage-dependent, modu-

lation by brevetoxin and classicalneurotoxins, bovine adrenal medul-lary cells, 1347

Sodium currentfast, interaction of taurine, myocytes

(rabbits), 1233rate-dependent effects of ethomozine,

conduction, newborn heart (dogs),608

Sodium nitroprusside, mechanism of meth-

ylene blue action, pulmonary arterial

smooth muscle (rabbits), 170

Somatostatin

depleting potency, cysteamine-relatedthiols and amines (rats), 752

nicotinic receptor-evoked release, myen-

teric plexus (guinea pigs), 1prostaglandins and, differential effects,

gastric histamine release to pentagas-

trin (dogs), 520

Sorbitol, endothelial cell dysfunction, aldosereductase and myo-inositol, elevatedglucose (rabbits), 153

Sorge, C. L., see Ray, S. D., 387Sorrentino, L., see Pieretti, S., 830

Spermidine, zinc and, NMDA receptor com-plex, 632

Sphingosine, role ofprotein kinase C, short-term transmission, mammalian neu-romuscular junction, 1269

Spielberg, S. P., see Leeder, J. S., 360Spinal cord, NSAIDS, antinociceptive ac-

tions, formalin test (rats), 136

Spiperonebinding of dopamine receptor ligands, in-

hibitory effect, adrenocorticotropin/

melanocyte-stimulating hormone-like peptides (rats), 787

m-chlonophenylpiperazine-induced neu-roendocrine changes, serotonin re-ceptor subtype-selective antagonists(mats), 588

5-HTIA-mediated hyperpolanization, CAland CA3 hippocampal pyramidalcells (rats), 350

SQ 33,961, thromboxane receptor antago-

nists, gastroprotective effects (rats),

374

St-587, intrathecal, nociceptive reflexes,

blood pressure (rats), 428

Staley J., see Moody, T. W., 311

Starke, K., see Szabo, B., 806

Startle reflex, acoustic, block of prepulseinhibition, 5HT18 (rats), 486

Staurosponine

modulation of neutrophil superoxide gen-

eration, kinase inhibitors, 1334

role ofprotein kinase C, short-term trans-

mission, mammalian neuromuscular

junction, 1269St. Claim, M. B. G., Llorens, J., O’Callaghan,

J. P., Peele, D. B., Morgan, K. T. andCrofton, K. M.: Olfactory toxicity of

�3,fl’-iminodipropionitrile in the rat,1432

Steinfels, G. F., see Tam, S. W., 1167Steranka, L. R., see Bunch, R. M., 933Steroids, hepatic microsomal polysubstrate

monooxygenase, effects of intrauter-me position (rats), 32

Stolfi, A., see Liu, W., 608Stomach

“artificial”, antacid and gastric mucosainteraction, 1206

gastric histamine release, differential ef-fects, somatostatin and prostaglan-

dins (dogs), 520

Striatumacetylcholine release and cocaine, dopa-

mine uptake blockade, local anes-

thetic properties (mats), 757

binding of dopamine receptor ligands, in-hibitory effect, adrenocorticotropin/

melanocyte-stimulating hormone-like peptides (rats), 787

carrier-mediated dopamine release, am-perozide (rats), 180

6-OHDA-induced lesions

clearance and diffusion, locally applieddopamine (rats), 1285

regional effects, dopamine D 1 receptors

(rats), 1454regulation, cholecystokinin mRNA con-

tent (rats), 368

suppression of zif268 basal expression,

chronic cocaine treatment, forebrain(rats), 343

Strobl, J. S. and Peterson, V. A.: Tamoxi-fen-resistant human breast cancercell growth: Inhibition by thiomida-zine, pimozide and the calmodulinantagonist, W-13, 186

Stromberg, I., see van Home, C., 1285Substance P, relaxation of trachea, release

of prostaglandin E,, neurokinin NK-

1 receptor (rats), 767Sudoh, K., see Yazawa, F., 201Sugimoto, T., see Iguchi, M., 194

Suh, H. H., Hudson, P., Fannin, R., Boulom,K., McMillian, M. K., Poisner, A. M.and Hong, J.-S.: Prolonged stimula-

tion of bovine adrenal chromaffincells with anachidonic acid and pros-taglandin E, increases expression of

the proenkephalin gene and the Se-cretion of [Met5]-enkephalin, 527

Sullivan, J. P., see Bunch, R. M., 933

Sulpiride, induction of opposing effects onpain, L-dopa (rats), 470

Sultana, M., see Ponreca, F., 147

Superoxide, generation, modulation by ki-nase inhibitors, neutrophils, 1334

Supemoxide anion, mechanism of methyleneblue action, pulmonary arterialsmooth muscle (rabbits), 170

Supenoxide dismutase, targeted delivery,chemical modification, mono- andpolysaccharide derivatives, 971

Suramin, acidic fibroblast growth factorbinding, FGF-flg, NIH-3T3 cells, 253

1512 Index Vol. 263

Suzuki, K., see Sakurada, S., 793Suzuki, Y., Matsumura, Y., Egi, Y. and Mom-

imoto, S.: Effects of losartan, a non-

peptide angiotensin II receptor an-tagonist, on norepinephrine overflowand antidiunesis induced by stimula-tion of renal nerves in anesthetizeddogs, 956

Swedberg, M. D. B., Shannon, H. E., Nickel,B. and Goldberg, S. R.: D-l6949 (An-

pirtoline): A novel serotonergic (5-HT,5) psychotherapeutic agent as-sessed by its discriminative effects inthe rat, 1015

Sympathetic nerve, renal activity, quinpi-role, renal norepinephrine spillover(rabbits), 806

Sympathetic nervous system, peripheral,naloxone-induced bradycardia, al-pha-2 adrenoceptors (rats), 918

Szabo, B., Crass, D. and Starke, K.: Effectof the dopamine D’ receptor agonist

quinpirole on renal sympatheticnerve activity and renal norepineph-nine spillover in anesthetized rabbits,806

Szabo, S., Reichlin, S., Bollinger-Gruber, J.A. and Brown, A.: Somatostatin de-pleting potency of cysteamine-re-lated thiols and amines in the rat:Structure-activity relation, 752

Szilagyi, J. E., see Slavik, K. J., 918

Tacrine, insulin secretion, �Rb� and 45Ca�efflux, pancreatic islets (rats), 494

Taglialatela, M., see Columbo, M., 979Takahashi, T., Tsunoda, Y., Lu, Y., Wiley,

J., and Owyang, C.: Nicotinic necep-ton-evoked release of acetylcholineand somatostatin in the myentenicplexus is coupled to calcium influxvia N-type calcium channels, 1

Takakura, Y., see Fujita, T., 971

Takanashi, M., see Yazawa, F., 201

Takata, Y., Shimada, F. and Kato, H.: Dif-ferential effects of diazoxide, cromak-aiim and pinacidil on adrenergic neu-rotransmission and �Rb� efflux inrat brain cortical slices, 1293

Takayama, S., see Furukawa, Y., 627

Takebayashi, Y., see Miyake, A., 1302

Takemori, A. E., see Porreca, F., 147

Takeuchi, Y., see Hata, F., 214

Tam, S. W., see Cook, L., 1159Tam,S.W.,seeCulp,S.G., 1175

Tam, S. W., Steinfels, G. F., Gilligan, P. J.,Schmidt, W. K. and Cook, L.: DuP734 [1-(Cycolpmopylmethyl)-4-

(2’(4”-fluorophenyl)-2’- oxoethyl)-pipemidine HBr], a sigma and 5-hydroxytryptamine, receptor antag-onist: Receptor-binding, electrophys-iological and neurophanmacologicalprofiles,1167

Tamaki, C., see Fujita, T., 971Tamoxifen, -resistant breast cancer cell

growth, thionidazine/pimozide/W-13(humans), 186

Tanigawara, Y., Okamura, N., Hirai, M.,Yasuhara, M., Ueda, K, Kioka, N.,Komano, T. and Honi, R.: Transportof digoxin by human P-glycoproteinexpressed in a porcine kidney epithe-

hal cell line (LLC-PK,), 840Taunine, interaction with fast sodium cur-

rent, myocytes (rabbits), 1233

Taurocholate, gastroprotective effects,

thromboxane receptor antagonists

(rats), 374Tavernier, G., Galitzky, J., Bousquet-

Melou, A., Montastruc, J. L. and Ber-lan, M.: The positive chronotropic

effect induced by BRL 37344 and

CGP 12177, two beta-3 adrenergic ag-

onists, does not involve cardiac beta

adrenoceptors but baroreflex mecha-nisms, 1083

Taylor, D. A., see Leedham, J. A., 15T#{233}l#{233}maque,S., see Claing, A., 1226

Temperature, dependence, dissociation con-

stant of naloxone, opioid delta recep-tons in vas deferens (mice), 1030

Teoh, S. K., see Mendelson, J. H., 505Tesfamariam, B., Brown, M. L., and Cohen,

R. A.: Aldose reductase and myo-ino-sitol in endothelial cell dysfunction

caused by elevated glucose, 153

Testosteroneeffects of alcohol, hypothalamic-pitui-

tary-gonadal axis, development(rats), 1056

effects of intrauterine position, hepatic

microsomal polysubstrate monooxy-

genase (rats), 32

Tetanus, role of protein kinase C, short-

term transmission, mammalian neu-romuscular junction, 1269

Tetrabenazine, block of prepulse inhibition,acoustic startle reflex (rats), 486

12-O-Tetradecanoylphombol-13-acetate,competitive inhibitor of group II

phospholipase A,, YM-26567-1 (rab-

bits), 1302

Tetraethylammonium, organic cation trans-

port, cationic drug interactions, prox-imal tubular cells (rats), 445

Tetrahydrocannabinol, cannabimimetic ac-tivity, aminoalkylindole analogs

(mice, rats), 1118

Theophylline

dimethylnitrosamine-induced hepatic ne-crosis, Ca�-activated DNA fragmen-

tation (mice), 387

papaverine inhibition, voltage-dependentCa� current, tracheal smooth muscle

(guinea pigs), 194Thermodynamics, temperature dependence,

dissociation constant of naloxone,

opioid delta receptors in vas deferens

(mice), 1030Thermogenesis, dopamine receptor subtype,

brown adipose tissue (rats), 823

Thiols, cysteamine-related, somatostatin

depleting potency (rats), 752

Thioridazine, inhibition, tamoxifen-resist-ant breast cancer cell growth (hu-mans), 186

Thomas, B. F., Wei, X. and Martin, B. R.:

Characterization and autoradi-

ographic localization of the cannabi-noid binding site in rat brain using

[‘H]11-OH-�9-THC-DMH, 1383

Thomas, D. B., see Gaginella, T. S., 1068Thomas, G., see Funck-Brentano, C., 780Thrombin

potentiation of cyclic AMP production,

human erythroleukemia cell line, 708prostaglandin production, glomerular

mesangial cells in culture (rats), 404Thromboxane, receptor antagonists, gastro-

protective effects (rats), 374

Thromboxane A,, prostaglandin H, recep-tors and, renal hemodynamic re-

sponse to blockade, angiotensin II

(rats), 905

Thromboxane B,, enhanced production,platelet-activating factor, fetal brain(rats), 562

Thurman, R. G., see Liu, Y., 651

Thymocytes, interleukin 1-activated, mor-

phine binding (mice), 451Thyroid, effects of 3,5-diiodothyropropionic

acid, heart (rats), 163

Thyroid hormones, induction of peroxiso-

mal enzyme activities, di-(2-ethyl-

hexyl)phthalate, parathyroid re-

plants (rats), 1105

Tobramycin, determinants of in vitro inter-

action, polyspartic acid, aminoglyco-

side antibiotics, 1464Toews, M. L., see Zhu, J., 1479

Tonello, C., see Nisoli, E., 823

Tonnaer, J. A. D. M., see Flonijn, W. J., 787Toombs, C. F., Norman, N. R., Groppi, V.

E., Lee, K. S., Gadwood, R. C. and

Shebuski, R. J.: Limitation of myo-cardial injury with the potassium

channel opener cromakalim and thenonvasoactive analog U-89,232: Vas-

cular vs. cardiac actions in vitro and

in vivo, 1261

Torphy, T. J., Zhou, H.-L. and Cieslinski,L. B.: Stimulation of beta adrenocep-tors in a human monocyte cell line(U937) up-regulates cyclic AMP-spe-cific phosphodiesterase activity, 1195

Torres, 0. A., see Andazola, J. J., 1111

Tracheabradykinin receptors, effect of Hoe 140

(guinea pigs), 1377inhibition of smooth muscle contraction,

M, muscaninic receptor antagonists(rabbits), 773

relaxation through release of prostaglaninE,, activation, epithelial neurokinin

NK-i receptor (rats), 767smooth muscle cells, papaverine inhibi-

tion, voltage-dependent Ca� current

(guinea pigs), 194Transcription regulatory factors, zif268

basal expression, suppression in fore-brain, chronic cocaine treatment(rats), 343

Transcytosis, biotin delivery to brain, co-

valent conjugate of avidin, monoclo-

nal antibody to transfernin receptor,

897

Tnifilieff, A., Da Silva, A., Landry, Y. andGies, J.-P.: Effect of Hoe 140, a new

B, noncompetitive antagonist, onguinea pig tracheal bradykinin recep-tons, 1377

2,4,5-Trihydroxyphenylalanine, neurotox-icity, protective effects of gangliosideGM1, Parkinson’s disease, 1440

Trippodo, N. C., see Grover, G. J., 1074

Trist, D., see Giacometti, A., 1241Trypan blue, allosteric modulation of M,

muscaninic receptor binding, recep-ton-mediated inhibition, adenylatecyclase (rats), 910

Tseng, L. F., see Xu, J. Y., 246Tsunoda, Y., see Takahashi, T., 1

Tuck, M. L., see Bergen, M. E., 78

Tudhope, S. R., see Labat, C., 800Turner, J. T., Camden, J. M., Kansra, S.,

1992 Index 1513

Shelton-James, D., Wu, H. and Hal-enda, S. P.: Potentiation of cyclicadenosine monophosphate produc-tion by thrombin in the human eryth-roleukemia cell line, HEL, 708

Tyrosine kinase, acidic fibroblast growthfactor binding, FGF-flg, NIH-3T3

cells, 253

U-89,232, cromakalim and, limitation of

myocardial injury, vascular vs. car-

diac actions (guinea pigs), 1261U-5449A, block of voltage-gated potassium

currents, neuroblastoma cells (mice),207

U937 cellsantisera characterization, naloxone-in-

sensitive receptor, �3-endorphin (rab-bits), 876

stimulation of beta adrenoceptors, phos-

phodiesterase activity, 1195Ueda, K., see Tanigawara, Y., 840Uezono, Y., see Wada, A., 1347Uhlmann, R., see Schwinger, R. H. G., 1352Ujihara, H. and Albuquerque, E. X.: Devel-

opmental change of the inhibition bylead of NMDA-activated currents incultured hippocampal neurons, 868

Ujihara, H. and Albuquerque, E. X.: Ontog-eny of N-methyl-D-aspartate-in-duced current in cultured hippocam-pal neurons, 859

Ulcerduodenal, cysteamine-related thiols and

amines, somatostatin depleting po-

tency (rats), 752

gastroprotective effects, thromboxane re-cepton antagonists (rats), 374

indomethacin-induced, pathogenesis, hy-peninsulinemia and adrenergic acti-vation (hamsters, rats), 951

Underwood, J. A., see Andazola, J. J., 1111

Ungen, T., see Veltmar, A., 1253Uremia, inhibition of plasma protein bind-

ing, renal organic acid transport(rats), 54

Unidine diphosphate-glucunonosyltransfer-ase, bilirubin, genetic deficiency,benzo(a)pyrene biotransformation(rats), 334

Uterus, effects of intrauterine position, he-patic microsomal polysubstrate mon-ooxygenase (rats), 32

van den Hoeven, Th., LeFevre, R., andMankes, R.: Effects of intrauterineposition on the hepatic microsomalpolysubstrate monooxygenase andcytosolic glutathione S-tnansferaseactivity, plasma sex steroids and rel-ative organ weights in adult male andfemale Long-Evans rats, 32

Vanecek, S. A., see Hoenicke, E. M., 276van Home C., Hoffer, B. J., Stromberg, I.

and Gerhardt, G. A.: Clearance anddiffusion of locally applied dopamine

in normal and 6-hydroxydopamine-lesioned rat striatum, 1285

Vantini, G., see Skaper, S. D., 1440Vasculature, mesenteric, calcitonin gene-re-

lated peptide, perivascular nervestimulation (rats), 1226

Vas deferens

neurogenic response, inhibitory effects,

calcium channel antagonists (guineapigs),214

opioid delta receptors, temperature de-

pendence, dissociation constant ofnaloxone (mice), 1030

Vasoconstriction, vasodilation and, sero-

tonin, kidney (rabbits), 928Vasopressin

angiotensin Il-induced release, adrenergicand angiotensinergic receptors, par-aventricular nucleus (rats), 1253

negative inotropic response, blocking ef-

fects, Vi and V2 antagonists (dogs),

627

Vasorelaxation, pharmacological activity of

nitroxyl (rabbits), 546

Vatier, J. L., Gao, Z., Fu-Cheng, X.-M.,Vitre, M.-T., Levy, D. A., Cohen, G.and Mignon, M.: Evidence for theinteraction between antacid and gas-tric mucosa using an “artificial stom-

ach” model including gastric mucosa,

1206Vein, nonadrenergic and noncholinergic am-

terial dilatation, venoconstriction,

calcitonin gene-related peptide(rats), 1226

Veltmar, A., Culman, J., Qadni, F., Rascher,W. and Unger, T.: Involvement ofadrenergic and angiotensinergic re-ceptors in the paraventricular nu-

cleus in the angiotensin Il-inducedvasopressin release, 1253

Verapamilchronic administration, Ca� channel

density, tissue (rats), 540digoxin transport, human P-glycoprotein

expression, LLC-PK, cells, 840potency, serotonin-exposed coronary and

internal mammary arteries (hu-

mans), 112

Veratridine, cooperative modulation, volt-

age-dependent sodium channels, bo-vine adrenal medullary cells, 1347

Verley, J., see Labat, C., 800

Versteeg, D. H. G., see Florijn, W. J., 787

Vitre, M.-T., see Vatier, J. L., 1206

Vomiting, initiation of, role of adrenergic

receptors, GI motor correlates (dogs),

395Vuong, A., see James, M. K., 84

W-13, inhibition, tamoxifen-resistant

breast cancer cell growth (humans),186

Wada, A., Uezono, Y., Anita, M., Yuhi, T.,Kobayashi, H., Yanagihana, N. andIzumi, F.: Cooperative modulation ofvoltage-dependent sodium channelsby brevetoxin and classical neurotox-

ins in cultured bovine adrenal med-ullary cells, 1347

Wagner, G. C., see Walsh, S. L., 617

Walcott, J., see Blandina, P., 61Walsh, R., see Gaginella, T. S., 1068

Walsh, S. L. and Wagner, G. C.: Motor

impairments after methampheta-mine-induced neurotoxicity in therat, 617

Wang, Y.-X. and Brooks, D. P.: The role ofadenosine in glycine-induced glomer-ular hyperfiltration in rats, 1188

Ward, S. J., see Compton, D. R., 1118Warner, J. A., see Columbo, M., 979Watanabe, H., Ohdo, S., Ishikawa, M. and

Ogawa, N.: Effects of social isolationon pentobarbital activity in mice: Re-

lationship to racemate levels and en-antiomer levels in brain, 1036

Watanabe, H., see Sakurada, S., 793Watanabe, S., see Ohno, M., 943Wax, P. M., see Hoffman, R. S., 698Weatherspoon, J. K., see Rigdon, G. C., 486Weber, S. J., Greene, D. L., Hruby, V. J.,

Yamamura, H. I., Porreca, F. andDavis, T. P.: Whole body and braindistribution of [‘H]cyclic [D-pen’, D-

pen’] enkephalin after intraperito-

neal, intravenous, oral and subcuta-neous administration, 1308

Wehner, J. M., see de Fiebre, N. C., 232

Wei, X., see Thomas, B. F., 1383Weisman, R. S., see Hoffman, R. S., 698Weitz, J., see Bloom, B. C., 690

Weitzberg, M., see Bunch, R. M., 933Wells, P. G., see Hu, Z., 334Whetzel, S. Z., see Pugsley, T. A., 1147Wick, A., see Angel, I., 1327Wiener, H. L., see Mahle, C. D., 1275Wild, K., see Raffa, R. B., 1030

Wiley, J., see Takahashi, T., 1Wiley, J. N., see Pugsley, T. A., 1147

WIN-55,212, cannabimimetic activity, ami-noalkylindole analogs (mice, rats),

1118Winquist, R. J., see Li, T., 928

Winter, J. C. and Rabin, R. A.: Yohimbineas a serotonergic agent: Evidencefrom receptor binding and drug dis-crimination, 682

Winter, J. N., see Dordal, M. S., 762Wise, L. D., see Pugsley, T. A., 1147

Wojcik, W. J., see McLeseky, S. W., 703Wong, P., see Fukuto, J. M., 546Woods, J. H., see Hoenicke, E. M., 276Woods, J. H., see Lu, Y., 499

Wu, H., see Turner, J. T., 708Wu, W.-H., see Choi, J. J., 49

Xu, J. Y., Fujimoto, J. M., and Tseng, L. F.:Involvement of supraspinal and �z

opioid receptors in inhibition of thetail-flick response induced by etor-phine in the mouse, 246

Yagasaki, 0., see Hata, F., 214Yaksh, T. L., see Malmberg, A. B., 136Yaksh, T. Y., see Malmberg, A. B., 264Yamaguchi, I., see Kunatani, K., 951Yamaguchi, I., see Matsuoka, N., 436Yamaguchi, Y., Fenoy, F. J., Roman, R. J.

and Nasjletti, A.: Angiotensin II in-

fluences the renal hemodynamic me-sponse to blockade of thromboxane

A, and prostaglandin H, receptors,905

Yamamoto, A., Hayakawa, E., Kato, Y.,Nishiura, A. and Lee, V. H.: A mech-

anistic study on enhancement of nec-tal permeability to insulin in the al-bino rat, 25

Yamamoto, B. K. and Meltzer, H. Y.: Theeffect of the atypical antipsychoticdrug, amperozide, on carrier-me-diated stniatal dopamine releasemeasured in vivo, 180

Yamamoto, H., see Miyake, A., 1302Yamamoto, T., see Ohno, M., 943

Yamamuna, H. I., see Weben, S. J., 1308

Yamasaki, S., see Liu, W., 608Yamazaki, M., see Kuratani, K., 951Yamazaki, M., see Matsuoka, N., 436Yanagihara, N., see Wada, A., 1347

1514 Index Vol. 263

Yasuhara, M., see Tanigawara, Y., 840Yasumoto, T., see Columbo, M., 979Yavin, E., see Kunievsky, B., 562Yazawa, H., Takanashi, M., Sudoh, K., In-

agaki, 0., and Honda, K.: Character-ization of [‘HJYM617, R-(-)-5-[2-

[[2[ethoxyning(n)-3”] (o-ethoxy-phenoxy)ethyl]amino}-propyl]-2-methoxybenzenesulfonami de HC1, apotent and selective alpha-i adreno-ceptor radioligand, 201

YMO6O, nodose ganglion and N1E-115neuroblastoma cells (rabbits), 1127

YM617, alpha-i adrenocepton radioligand(rats), 201

YM-26567-l, competitive inhibitor, group II

phospholipase A, (rabbits), 1302Yocca, F. D., see Mahle, C. D., 1275Yohimbine, serotonergic agent (rats), 682Yoshikawa, T. and Pandnidge, W. M.: Biotin

delivery to brain with a covalent con-

jugate of avidin and a monoclonal

antibody to the transferrin receptor,

897

Yue, T.-L., Cheng, H.-Y., Lysko, P. G.,McKenna, P. J., Feuerstein, R., Gu,J.-L., Lysko, K. A., Davis, L. L., andFeuerstein, G.: Carvedilol, a newvasodilator and beta adrenoceptorantagonist, is an antioxidant and freeradical scavenger, 92

Yuhi, T., see Wada, A., 1347

Zabko-Potapovich, B., see Albrightson, C.

R., 404Zhang, Z.-H., Follmer, C. H., Sarma, J. S.

M., Chen, F., and Singh, B. N.: Effectof ambasilide, a new class III agent,on plateau currents in isolated guinea

pig ventricular myocytes: Block ofdelayed outward potassium currents,40

Zhou, H.-L., see Torphy, T. J., 1195Zhu, J., Toews, M. L. and Hexum, T. D.:

Neuropeptide Y inhibits forskolin-

stimulated adenylate cyclase in bo-

vine adrenal chromaffin cells via apertussis toxin-sensitive process,

1479Zhu, Y., Im, H. K., and Im, W. B.: Block of

voltage-gated potassium currents by

anticonvulsant U-54494A in mouse

neuroblastoma cells, 207Zia, F., see Moody, T. W., 311Zikovic, B., see Perrault, G., 298

Zimmerman, B. G., see Hajj-ali, A. F., 158Zinc

ontogeny of NMDA-induced current, hip-

pocampal neurons (rats), 859spermidine and, NMDA receptor corn-

plex, 632

Zirrolli, J. A., see Lin, L.-H., 569

Zolpideminhibited flumazenil binding, central w

site ligands, central nervous system

(rats), 884repeated treatment, lack of tolerance and

physical dependence (mice), 298

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