ANTIBIOTIC RESISTANCE AND MECHANISMS

WORKSHOP FOR RESEARCHERS

THE BIRMINGHAM CONFERENCE AND EVENTS CENTRE, HILL STREET, BIRMINGHAM, B5 4EW28-29 NOVEMBER 2019

PROGRAMME

WELCOME TO THE FOURTEENTH ANTIBIOTIC RESISTANCE AND MECHANISMS WORKSHOP FOR RESEARCHERS

This workshop will offer members of the UK community researching mechanisms of antimicrobial resistance the opportunity to meet, to consolidate and extend the expertise held within individual laboratories in the United Kingdom. It will provide a much needed forum to allow the sharing of knowledge between all grades of researchers, including PhD students and technicians. As in previous years, the British Society for Antimicrobial Chemotherapy will underwrite the majority of costs for this meeting. The focus of our support this year will be on those who present a poster at the meeting and we will be offering discounted places to those with accepted poster abstracts. To apply for a discounted place we kindly ask that you submit a poster abstract along with your registration.

We encourage everyone who can support their own attendance to pay the full registration fee.

We look forward to welcoming you in Birmingham.

Jessica Blair and Andy EdwardsChairs, Programme Committee

AGENDA28 NOVEMBER

2019

1300 LUNCH, REGISTRATION, POSTER VIEWING

1345 Introductory Remarks Dr Jessica Blair, University of Birmingham

SESSION ONE: Global AMR Chair: Thamarai Schneiders, Dr Alasdair Hubbard, Liverpool School of Tropical Medicine

1400 Parallelism in the evolution of multi-drug resistant clones of gram negative pathogens Dr Alan McNally, University of Birmingham

Use of Whole Genome Sequencing in antimicrobial resistance surveillance Dr Marie Chattaway, Public Health England

Antifungal resistance: a global perspective Dr Tihana Bicanic, St Georges, University of London

1540 COFFEE BREAK

SESSION TWO: Transmission of Resistance Chair: Vicky Enne, UCL, Royal Free Campus, Chris Furniss, Imperial College London

1555 Targeting AMR plasmids: one way to reduce resistance Dr Michelle Buckner, University of Birmingham

Genome hypermobility via lateral transduction Professor José Penades, University of Glasgow

The ecology and evolution of resistance plasmids Professor Mike Brockhurst, University of Sheffield

SESSION THREE: Offered papers Chair: Fraser Scott, University of Strathclyde, Kathryn Maskew, The AMR Centre

1710 Antipsychotic drugs are competitive inhibitors of the AcrAB-TolC efflux pump Elizabeth Grimsey, University of Birmingham

A genome wide study to understand triclosan resistance mechanisms in Escherichia coli Muhammad Yasir, Quadram Institute Bioscience

The involvement of KvrA and NlpD loss of function in cefuroxime susceptibility in Klebsiella pneumoniae Punyawee Dulyayangkul, University of Bristol

An Open Innovation Model for screening novel compounds for antimicrobial activity Charlotte Hind, Senior Scientist, Public Health England

1800 POSTER SESSION 1 - 1900

2000 Dinner

ANTIBIOTIC RESISTANCE AND MECHANISMS:

WORKSHOP FOR RESEARCHERS

THE BIRMINGHAM CONFERENCE AND EVENTS CENTRE, HILL STREET,

BIRMINGHAM, B5 4EW

AGENDA29 NOVEMBER

2019

0900 Introductory Remarks Dr Andy Edwards, Imperial College London

SESSION FOUR: New Antibiotics and Drug discovery Chair: Mark Sutton, Public Health England, Eleftheria Trampari, Quadram Institute Bioscience

0905 The Global Antibiotic Research & Development Partnership - from discovery to patients Professor Laura Piddock, University of Birmingham

Using mobile CRISPR-Cas9 to target antibiotic resistance in microbial communities Dr Stineke van Houte, University of Exeter

Epidermicin: from natural product discovery to lead commercial candidate Professor Matt Upton, University of Plymouth

Can the beta-lactams be beaten? Professor Chris Schofield, University of Oxford

1025 COFFEE BREAK & POSTER SESSION 2

SESSION FIVE: BSAC grant holders Chair: Despoina Mavridou, MRC Centre for Molecular Bacteriology & Infection, Akshay Sabnis, Imperial College London

1125 From systems biology to target and mode of action studies in fungal pathogens of man Professor Elaine Bignall, University of Manchester

Targeting bacterial two-component regulatory systems to modulate antimicrobial resistance Dr Daniel Neill, University of Liverpool

Exploring antimicrobial resistance in antibody deficient hosts: over-treatment, under-treatment or inevitability? Dr David Lowe, Royal Free London

SESSION SIX: Outreach Chair: Adam Roberts, Liverpool School of Tropical Medicine, Elaine Waters, National University of Ireland

1225 Researching and communicating natural product antimicrobials Dr Freya Harrison, University of Warwick

1245 ‘We’ve had enough of experts’: AMR in the age of post-truth politics Mr Michael Corley, BSAC

1300 Closing remarks and poster prizes

ANTIBIOTIC RESISTANCE AND MECHANISMS:

WORKSHOP FOR RESEARCHERS

THE BIRMINGHAM CONFERENCE AND EVENTS CENTRE, HILL STREET,

BIRMINGHAM, B5 4EW