Antonio Pio Masciotra Campobasso – Molise – Italy Website YouTube channel
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Antonio Pio Masciotra Campobasso – Molise – Italy Website www.masciotra.net YouTube channel https://www.youtube.com/channel/UCgCj21nKGAhR997I a3-QegQ Intrahepatic cholelithiasis in a 29 years old woman without symptoms
Antonio Pio Masciotra Campobasso – Molise – Italy Website YouTube channel
Antonio Pio Masciotra Campobasso Molise Italy Website
www.masciotra.netwww.masciotra.net YouTube channel
https://www.youtube.com/channel/UCgCj21nKGAhR997Ia3-QegQ
Intrahepatic cholelithiasis in a 29 years old woman without
symptoms
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Ultrasound images of intrahepatic hyperechoic foci. In this
patient we can see hyperechoic foci with diffuse topography
compatible with lipid deposits along the luminal surface of the
intrahepatic biliary tree, here limited to segments 6 and 7. These
multiple dots, less than 1 mm in diameter, cast short echogenic
trail without acoustic shadows and sometimes look like comet tails.
They are typically distributed along the portal arborizations in
single line (end to end or in indian file) and may be associated
with intrahepatic sludge or microlithiasis casting typical acoustic
shadows. In this patient gallbladder has no stones. In the slides
n. 3 and 4 you can see that the images were taken with patient in
supine and orthostatic positions to exclude that hyperechoic foci
were due to aerobilia (in which case their distribution would have
been changed, going the air upward). In a young woman like in this
case we could suppose a Low phospholipid associated cholelithiasis,
sometimes associated to an ABCB4 gene mutation. Phospholipids are
the major carrier and solvent of cholesterol and they exert a
protective effect against bile saltinduced biliary mucosa injury.
Mutations in the ABCB4 gene are thought to be responsible for
progressive intrahepatic cholestasis type 3 and heterozygous
mutations have been also reported in patients presenting with a
history of intrahepatic cholestasis of pregnancy or with a
cholangiopathy referred to as anti-mitochondrial antibody (AMA)
negative primary biliary cirrhosis (PBC). Defect in ABCB4 function
causes the production of bile with low phospholipid content,
increased lithogenicity and high detergent properties leading to
bile duct luminal membrane injuries and resulting in cholestasis
with increased serum GGT activity.
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Antonio Pio Masciotra Campobasso Molise Italy Email
[email protected] Website www.masciotra.net YouTube Channel
https://www.youtube.com/ch annel/UCgCj21nKGAhR997I a3-QegQ
Intrahepatic cholelithiasis in a 29 years old woman without
symptoms