APBio-pp1.3

Embed Size (px)

Citation preview

  • 8/4/2019 APBio-pp1.3

    1/92

    ,5907

    %002897417,3.40.:08

  • 8/4/2019 APBio-pp1.3

    2/92

    7,3.40.:08

    ,7-4389014:3/,9434147,3.

    240.:087,3.240.:08,70

    .4254:3/84190314:3/3;3938,,8.439,3.,7-43,3/

    /7403

    .4;,039-43/0/

    :8:,,70

    :8:,,884.,90/910

  • 8/4/2019 APBio-pp1.3

    3/92

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    4/92

    7,3.40.:08

    .,7-4314:7;,03.000.9743820,389.,3

    147214:7.4;,039-43/8

    98708:98343.,38738

    5488-0/4:-0,3/9750-43/8

    .4397-:90948,50,3/7/9

  • 8/4/2019 APBio-pp1.3

    5/92

    ,7-43$009438

  • 8/4/2019 APBio-pp1.3

    6/92

    %0,7-43$00943,3/

    :3.943,74:58/74.,7-438

    :89/7403,3/.,7-43/7454-.34354,7

    /74.,7-43/07;,9;08

    .,3,;074:5841,9428.,0/

    1:3.943,74:58

    41903/745.54,7

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    7/92

    :3.943,74:58

  • 8/4/2019 APBio-pp1.3

    8/92

    #

    %0,7-43$00943,3/

    :3.943,74:58.43909

    :89/74.,7-43

    34354,7

    /7454-.

    /74

    .,0/,.448

    54,714728-43/8

    14:3/38:,788420,234,./8

    7,3.40.:08

    #

  • 8/4/2019 APBio-pp1.3

    9/92

    %0,7-43$00943,3/

    :3.943,74:58.439,7-43

    .,0/,/0/08

    038439003/

    .,0/094308

    0383902//0

    54,7

    14:3/38:,78

    #

    # #

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    10/92

    %0,7-43$00943,3/

    :3.943,74:58.439,7-4

    .,0/.,7-4.,./8

    54,7,./.

    14:3/31,99,./8,234,./8

    #

    #

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    11/92

    %0,7-43$00943,3/

    :3.943,74:58.439234

    .,0/,2308

    54,7-,8.14728-43/8

    14:3/3,234,./8

    #

    #

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    12/92

    %0,7-43$00943,3/

    :3.943,74:58.439$:1/7

    .,0/948

    14728/8:1/0-43/8

    14:3/38420,234,./8

    0589,-09079,7574903

    897:.9:70

    #$

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    13/92

    %0,7-43$00943,3/

    :3.943,74:58.439!485,90

    54,7,./.

    .,0/47,3.5485,90

    14:3/33:.049/08548545/8

    !

    # !

    #

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    14/92

    %0,7-43$00943,3/

    :3.943,74:58.439842078.4254:3/898,20

    240.:,71472:,-:9/1107039

    897:.9:708

    /1107039897:.9:70820,38

    /11070391:3.9438.,3-0/1107039,77,30203941

    -43/885,9,70,94385847

    277472,08410,.4907

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    15/92

    842078

  • 8/4/2019 APBio-pp1.3

    16/92

    842078

  • 8/4/2019 APBio-pp1.3

    17/92

    %0,.74240.:084108,70/74.,7-43/07;,9;08

    .,7-4/7,908

    5/8

    5749038

    3:.0.,./8

    2,/04182,07240.:08.4;,039

    430/

    243420782,8:-:39

    542072,38:-:39830/

    94 0907

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    18/92

    %,-0

  • 8/4/2019 APBio-pp1.3

    19/92

    %0,.74240.:084108.439,542078,702,/0908,20-,8.

    ,

    839088,550383/0/7,943

    70,.9438 ,90787024;0/,84.,0/.43/038,94370,.9438

    706:708030703/0743.

    988,3,-482 -:/3-07240.:08

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    20/92

    %0,.74240.:084108.439-,8.1472:,

    24342072434207

    54207,907

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    21/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    22/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    23/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    24/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    25/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    26/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    27/92

    0/7,943$39088

    #

    #

  • 8/4/2019 APBio-pp1.3

    28/92

    0/7,943$390884143

  • 8/4/2019 APBio-pp1.3

    29/92

    %0,.74240.:084108.439,542078,70-7403908,20

    -,8.,

    /08943,550383/7488

    70,.9438 ,9078,//0/

    03078700,80/00743.

    988.,9,-482 -240.:08

    ,70-7403

    7,3.40.:08

  • 8/4/2019 APBio-pp1.3

    30/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    31/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    32/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    33/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    34/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    35/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    36/92

    /7488/08943

    #

    #

  • 8/4/2019 APBio-pp1.3

    37/92

    %0,.74240.:084108.439$:22,7907289,94940907

    7,3.40.:08

    & #

    839088 /08943

    .43/038,943 /7488

    03/0743. 00743.

    ,3,-4. .,9,-4.

  • 8/4/2019 APBio-pp1.3

    38/92

    ,7-4/7,908,70:80/1470307

    47897:.9:70

    4348,..,7/08

    ,84343,882508:,78.,7-438

    2434207841548,..,7/08

    57010770/84:7.04103071472489

    47,3828

    0,2508:.48017:.94807-480

    /047-480,,.9480

    ,7-4/7,908

  • 8/4/2019 APBio-pp1.3

    39/92

    $97:.9:7041:.480

  • 8/4/2019 APBio-pp1.3

    40/92

    $97:.9:7041:.480

  • 8/4/2019 APBio-pp1.3

    41/92

    4348,..,7/08

  • 8/4/2019 APBio-pp1.3

    42/92

    ,7-4/7,908

    8,..,7/08.43889419424348,..,7/08

    430/3,/0/7,94370,.943

    :80/94894704797,3854798:,7

    0,25088:.7480,.94802,9480

  • 8/4/2019 APBio-pp1.3

    43/92

    $97:.9:7041$:.7480

  • 8/4/2019 APBio-pp1.3

    44/92

    ,94801472,943

  • 8/4/2019 APBio-pp1.3

    45/92

    ,7-4/7,908

    !48,..,7/08.43889412,324348,..,7/08

    430/

    :80/14703078947,0

    89,7. 5,398

    .403 ,32,8

  • 8/4/2019 APBio-pp1.3

    46/92

    ,$9,7.

  • 8/4/2019 APBio-pp1.3

    47/92

    -.403

  • 8/4/2019 APBio-pp1.3

    48/92

    ,7-4/7,908

    !48,..,7/08.4393:0/:80/,8897:.9:7,2,907,8

    .0:480 5,39814728.0,8

    5059/4.,3 -,.907,14728.0

    ,8.93 1:314728.0,8

    .93,797454/8:80/3

    048009438

  • 8/4/2019 APBio-pp1.3

    49/92

    0:480

  • 8/4/2019 APBio-pp1.3

    50/92

    $97:.9:7,.,7-4/7,908

    /

  • 8/4/2019 APBio-pp1.3

    51/92

    5/8,70:80/14703078947,0

    202-7,30884204724308,3/

    57490.9435/8,70/7454-.

    %7.07/081,98,3/48

    2,/0411,99,./8430/94.074.,874:58

    1,99,./8,70/74.,7-43.,38

    47.,7-4389,74:5

    5/8

    /

  • 8/4/2019 APBio-pp1.3

    52/92

    %7.07/08.439:80/94894700307.,

    38:,90.:843

    8,9:7,90/ 1,99,./8,;034/4:-0

    -43/8,;0,82:.,85488-0:8:,84/,974429025

    :38,9:7,90/ 1,99,./8,;0/4:-0

    -43/8:8:,6://:09438

    5/8

    / 9 9

  • 8/4/2019 APBio-pp1.3

    53/92

    ,0/7,94370,.943

    - % 1 1 99 /

  • 8/4/2019 APBio-pp1.3

    54/92

    -%508411,99,./8

    /

  • 8/4/2019 APBio-pp1.3

    55/92

    !48545/8.43889411,99,./8,3/

    5485,9074:5,99,.0/94.074

    1,99,./8,70/7454-.

    5485,9074:58/745.2,0:5202-7,308

    5/8

    ! /

  • 8/4/2019 APBio-pp1.3

    56/92

    !48545/8

    ! /

  • 8/4/2019 APBio-pp1.3

    57/92

    !48545/8

  • 8/4/2019 APBio-pp1.3

    58/92

    - /

  • 8/4/2019 APBio-pp1.3

    59/92

    02-7,3024/0

    /

  • 8/4/2019 APBio-pp1.3

    60/92

    $9074/8.4388941/74.,7-437389

    ,99,.0/1:3.943,74:58

    2,/01742.4089074

    :80/,84724308,3/14789,-3.0202-7,308

    5/8

    , 4089074

  • 8/4/2019 APBio-pp1.3

    61/92

    ,4089074

    $9074/ ;0789

  • 8/4/2019 APBio-pp1.3

    62/92

    $9074/;0789

    - %08948907430

  • 8/4/2019 APBio-pp1.3

    63/92

    -%08948907430

    . 897403

  • 8/4/2019 APBio-pp1.3

    64/92

    .897403

    5/8

  • 8/4/2019 APBio-pp1.3

    65/92

    ,08.438894143.,31,99,./89

    43.,3,.448

    41903:80/14757490.943

    0,25080,7,-008,.4,9384317:9,3/0,;08

    5/8

    , , 43 5:28

  • 8/4/2019 APBio-pp1.3

    66/92

    ,,435:28

    - , 3 430.42-

  • 8/4/2019 APBio-pp1.3

    67/92

    -,3430.42-

    5/ 8:22,7

  • 8/4/2019 APBio-pp1.3

    68/92

    5/8:22,7

    !749038

  • 8/4/2019 APBio-pp1.3

    69/92

    !749038,7041572,725479,3.0

    9490897:.9:70,3/1:3.94341

    .0854207841,234,./8

    ,,;0:36:0574507908

    ,7089,3/2489,-:3/,39

    -4240.:08

    :80/1478:554790320897,385479

    /01038083,3472430824943

    ,3/2470

    !749038

    !749038

  • 8/4/2019 APBio-pp1.3

    70/92

    234./8/11070393/8,.4388941,.0397,.,7-439,3

    ,23474:5.,7-474:5

    ,3/,3#74:5#02,3/0741240.:0

    #74:58.,3-054,734354,7

    ,./.47-,8.

    !749038

    4354,7 234 ./8

  • 8/4/2019 APBio-pp1.3

    71/92

    4354,7234./8

    !4,7 ,3/ ,70/ 234 ./8

  • 8/4/2019 APBio-pp1.3

    72/92

    !4,7,3/,70/234./8

    !749038

  • 8/4/2019 APBio-pp1.3

    73/92

    !059/08,234,./8395059/0-43/8

    .,7054,7

    5059/094472470-43/0/,234,./8

    545059/0.,341,234,./8

    430/- 0 9/0-43/8

    !749038

    !059/0 839088

  • 8/4/2019 APBio-pp1.3

    74/92

    !059/0839088

    !749038

  • 8/4/2019 APBio-pp1.3

    75/92

    $,5041!749038!72,7806:03.041,234,./8

    /0907230890:92,90897:.9:70

    90701470/09072308:92,90

    1:3.943$0.43/,79898,3/14/841,234

    ,./.,3

    /:094/7403-43/8- 047. 50,90/8009

    !749038

    !749038

  • 8/4/2019 APBio-pp1.3

    76/92

    $,5041!749038.439%079,7,//943,14/3394,

    570.808,50

    3;4;08/7403-43/843.

    -43/8.4;,039-43/8/8:1/0-7/08/7454-.3907,.9438

    .,30839025475.,3

    /03,9:70 574903857490348083,9:7,8,50

    ":,9073,7,//341430412470

    4 0 9/0894 0907

    !749038

    !74903 47,3,943

  • 8/4/2019 APBio-pp1.3

    77/92

    !7490347,3,943

    :.0. ./8

  • 8/4/2019 APBio-pp1.3

    78/92

    :.0.,./889470,3/97,3829

    0309.31472,943542078413:.049/08

    $97:.9:7041,3/#3:.049/08 .4388941,.,7-43

    8:,75485,90,3/3974034:8-,80

    572/308 ,;0,830735:7308 ,;0,/4:-073

    :.0../8

    4 41 0309. 31472,943

  • 8/4/2019 APBio-pp1.3

    79/92

    4410309.31472,943

    , :.049/0 897:.9:70

  • 8/4/2019 APBio-pp1.3

    80/92

    ,:.049/0897:.9:70

    - 047-480 ;8 7-480

  • 8/4/2019 APBio-pp1.3

    81/92

    -047-480;87-480

    . !72/308 ;8 5:7308

  • 8/4/2019 APBio-pp1.3

    82/92

    .!72/308;85:7308

    :.0. ./8

  • 8/4/2019 APBio-pp1.3

    83/92

    $97:.9:7041,3/#.439572/308.94830

    9230%#572/308.94830:7,.

    :7308,/0330

    :,330/4:-0897,3/0/54207

    /4:-008,50.439,38/047-4809084942,0#

    %

    :.0../8

    $97:.9:70

  • 8/4/2019 APBio-pp1.3

    84/92

    $97:.9:70

    :.0. ./8

  • 8/4/2019 APBio-pp1.3

    85/92

    $97:.9:7041,3/#.439#830897,3/0/54207

    .439,387-4809084942,0574903

    97,38,943&

    $06:03.0413:.049/08/08.7-0572,7897:.9:70415749038

    :.0../8

    # $97:.9:70

  • 8/4/2019 APBio-pp1.3

    86/92

    #$97:.9:70

  • 8/4/2019 APBio-pp1.3

    87/92

    :.0. ./8

  • 8/4/2019 APBio-pp1.3

    88/92

    /034830975485,90

    3:.049/0.,0/%!.43889841,/03307-480

    5485,908

    0307.:7703.41.08700,80415485,90700,808

    0307,//3,5485,90706:7080307

    :.0../8

    ,%!85,.01324/0

  • 8/4/2019 APBio-pp1.3

    89/92

    5

    -%!0307.43;07843

  • 8/4/2019 APBio-pp1.3

    90/92

    7,3..4254:3/88:22,7

  • 8/4/2019 APBio-pp1.3

    91/92

    5

    !059/043/

  • 8/4/2019 APBio-pp1.3

    92/92

    5