Office of Continuing Medical EducationTurner 20, 720 Rutland AvenueBaltimore, Maryland 21205-2195

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DATED MATERIAL

CONTINUING MEDICAL EDUCATION

Department of Otolaryngology – Head and Neck Surgery Johns Hopkins University School of MedicinePresents

Updates in Recurrent Respiratory Papilloma:Clinical and Research Perspectives

Updates in Recurrent Respiratory Papilloma:Clinical and Research Perspectives

May 30-31, 2014 Baltimore, Maryland

DESCRIPTIONRecurrent respiratory papilloma is a very frustrating disease for both physicians and patients. The overall approach to care of patients with papilloma has not changed since the disease was !rst recognized, with focus on surgical debridement of the papilloma whenever it grows large enough to interfere with airway or voice. Though surgery provides temporary relief of symptoms, it is expected that the disease will return and will bring with it need for further surgery. With these repeated surgeries comes the risk of cumulative scar tissue of the vocal cords and concern of reduced laryngeal function. Fortunately, both clinical and research advances in recurrent respiratory papilloma herald the promise of less-frequent surgery and improved clinical outcomes. The Updates in Recurrent Respiratory Papilloma: Clinical and Research Perspectives CME course will provide a learning opportunity where participants can discuss current state-of-the-art advances in treatment of papilloma, including the role of photoangiolytic lasers, o"ce-based treatments, and adjuvant therapies. A forum for exchange of research advances such as vaccine therapy and immunologic treatment for papilloma will allow participants to discuss the future of papilloma care.

WHO SHOULD ATTENDThis activity is intended for local, regional, and national otolaryngologists, pediatricians, infectious disease experts, and other physicians and allied health professionals with an interest in recurrent respiratory papilloma.

OBJECTIVESAfter attending this activity, the participant will demonstrate the ability to:

adult and pediatric RRP.

impact treatment for RRP.

clinical care of RRP in the future.

ACCREDITATION STATEMENT The Johns Hopkins University School of Medicine is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

CREDIT DESIGNATION STATEMENT The Johns Hopkins University School of Medicine designates this live activity for a maximum of 10.75 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. OTHER CREDITS American Nurses Credentialing Center (ANCC) accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. American Academy of Nurse Practitioners National Certi!cation Program accepts AMA PRA Category 1 Credit™ from organizations accredited by the ACCME.American Academy of Physician Assistants (AAPA) accepts certi!cates of participation for educational activities certi!ed for AMA PRA Category 1 Credit™ from organizations accredited by the ACCME. Physician assistants may receive a maximum of 10.75 hours of Category 1 credit for completing this program.The Johns Hopkins University has approved this activity for 10.25 contact hours for non-physicians.

POLICY ON SPEAKER AND PROVIDER DISCLOSUREIt is the policy of the Johns Hopkins University School of Medicine that the speaker and provider disclose real or apparent con#icts of interest relating to the topics of this educational activity, and also disclose discussions of unlabeled/unapproved uses of drugs or devices during their presentation(s). The Johns Hopkins University School of Medicine OCME has established policies in place that will identify and resolve all con#icts of interest prior to this educational

GENERAL INFORMATIONREGISTRATIONMay 30, 2014 – 7:30-8:00 a.m.

LOCATIONThomas B. Turner BuildingJohns Hopkins University School of Medicine720 Rutland AvenueBaltimore, Maryland 21205

and campus parking information are available on our website under the contact and travel section at www.HopkinsCME.edu. Handicapped parking is available in the nearby Rutland Garage. Johns Hopkins is smoke-free.

FEES

Methods of Payment: Payment by check or credit card must accompany the registration form prior to the activity. On-site payments by credit card only. Foreign

registration fee includes instructional materials, continental breakfasts, refreshment breaks and lunches.Physicians ..........................................................................................................................................................$350 Residents*/Fellows*/Nurses/ Physician Assistants and Allied Health Professionals ................................................................................................................... .$175*with veri!cation of status

You will receive a con!rmation by e-mail if you have provided your e-mail address. Otherwise con!rmation will be sent by mail. If you have not received it by May 24, 2014, call (410) 502-9634 to con!rm that you are registered. A certi!cate of attendance will be sent by July 11, 2014 to the e-mail address you provide on the registration form. The Johns Hopkins University reserves the right to cancel or postpone any activity due to unforeseen circumstances. In this event, the University will refund the registration fee but is not responsible for travel expenses. Additionally, we reserve the right to change the venue to a comparable venue. Under such circumstances registrants will be noti!ed as soon as possible.

LATE FEE AND REFUND POLICYA $50 late fee applies to registrations received after 5:00 p.m. EST on May 24, 2014. A handling fee of $50 will be deducted for cancellation. An additional fee may apply for cancellation of other events, including workshops and social activities. Refund requests must be received by fax or mail by May 24, 2014. No refunds will be made thereafter. Transfer of registration to another Johns Hopkins conference in lieu of cancellation is not possible.

EVALUATIONA form will be available to attendees to evaluate each session and each speaker’s presentation, as well as to identify future educational needs.

OUTCOMES SURVEYA survey will be sent to all physician attendees within three months post activity to assist us in determining what impact this activity had on the attendee’s practice.

EMERGENCY CALLSOn May 30-31, 2014 direct emergency calls to the Hopkins registration desk, (410) 955-3673. Messages will be posted for participants.

AMERICANS WITH DISABILITIES ACTThe Johns Hopkins University School of Medicine fully complies with the legal

Please notify us if you have any special needs.

TO REGISTER or FOR FURTHER INFORMATIONRegister Online (credit card and eCheck) www.HopkinsCME.edu Register by Phone (credit card only) (410) 502-9634Register by Fax (866) 510-7088Con!rmation/Certi!cates (410) 502-9634General Information (410) 955-2959E-mail the O"ce of CME cmenet@jhmi.eduFollow us on Twitter: http://twitter.com/HopkinsCMEFacebook: http://www.facebook.com/HopkinsCMEFor general information, the direct link for this CME activity web page is:

Friday, May 30, 2014 7:30 - 8:00 Registration and Continental Breakfast 8:00 - 8:20 Welcome and Course Introduction

Lee Akst, MD and Nazaneen Grant, MD 8:20 - 8:50 The Biology of HPV Infection

Sara Pai, MD, PhD 8:50 - 9:20 RRP by the Numbers: Epidemiologic Gestalt

Farrel Buchinsky, MD 9:20 - 9:40 RRP in the 21st Century: A Patient’s Perspective

Jennifer Woo, MS 9:40 - 10:00 Refreshment Break 10:00 - 10:20 Approaches to RRP Care: General Philosophies

Lee Akst, MD 10:20 - 10:50 Unwieldy Workhorse: Operative Management of RRP

with the CO2 Laser Clint Allen, MD

10:50 - 11:20 A Weapon of Minor Destruction: KTP Angiolytic Laser Use in the OR Nazaneen Grant, MD

11:20 - 12:05 The Development of the HPV Vaccine C. Richard Schlegel, MD

12:05 - 1:00 Lunch 1:00 - 1:30 Treatment of RRP in Children: Strategies for Safe and

E!cient Surgery David Tunkel, MD

1:30 - 2:00 Use of Conditionally Reprogrammed Cells for RRP Studies Hang Yuan, PhD

2:00 - 2:30 O!ce-Based KTP Laser Treatment of Laryngeal Papilloma Alexander Hillel, MD

2:30 - 3:00 Medical and Surgical Management of Severe Pediatric RRP Diego Preciado, MD

3:00 - 3:20 Refreshment Break 3:20 - 4:05 Avastin, O!ce-Based Treatment, and the Future of

RRP Care Steven Zeitels, MD

4:05 - 4:45 PANEL: State-of-the-Art in Clinical Care 4:45 Adjourn

Saturday, May 31, 2014 7:30 - 8:00 Continental Breakfast 8:00 - 8:30 Adjuvant Care of RRP

Simon Best, MD 8:30 - 9:15 The Role of Prostaglandin E2 in RRP

Bettie Steinberg, PhD 9:15 - 9:45 Treatment of Pulmonary Disease

David Feller-Kopman, MD 9:45 - 10:05 Refreshment Break 10:05 - 10:35 The Great Escape: How HPV Evades the Immune System

Sara Pai, MD, PhD 10:35 - 11:05 HPV by the Millions; RRP by the Thousands:

Susceptibility Insights Farrel Buchinsky, MD

11:45 Adjourn

The Johns Hopkins University School of Medicine takes responsibility for the content, quality and scienti!c integrity of this CME activity.

This schedule is subject to change.

PROGRAM

COMMERCIAL SUPPORT Applications for commercial support from health care related industries are pending. A complete list of contributors will be provided in the syllabus. Please note that commercial support received is solely for the educational component of the activity and will not be used to provide food and beverage.

Please note: The Physician Payments Sunshine Act was enacted by Congress to increase public awareness of !nancial relationships between drug and medical device manufacturers and physicians. In compliance with the requirements of this Act, the commercial supporter/s of this activity may require the Johns Hopkins University School of Medicine to report certain professional information (such as name, address, National Provider Identi!er (NPI), and State License number) of physician attendees who receive complimentary food and beverage in conjunction with a CME activity. The commercial supporter is required to submit the collected data to the Centers for Medicare and Medicaid Services which will then publish the data on its website.

PAYMENT MUST ACCOMPANY FORM TO CONFIRM YOUR REGISTRATION.! I am a Johns Hopkins speaker for this activity.

Please type or print clearly:last name first name m.i.

highest degree primary specialty Hopkins faculty/staff only JHED ID

For Physicians Only:

NPI – 10 digits State License # State of License

mailing address

city state ZIP country

daytime telephone fax number

e-mail

You will receive a con!rmation notice and your attendance certi!cate by e-mail if you provide your e-mail address. ! Check here if you wish to receive e-mail notices about upcoming CME activities.What do you hope to learn by attending this activity?

_____________________________________________________________________

Please notify us if you have any special needs.

_____________________________________________________________________

Registration Fees:! Physicians ...............................................................................................................................................................$350! Residents*/Fellows*/Nurses/ Physician Assistants and

Allied Health Professionals ..........................................................................................................................$175*with veri!cation of statusThe registration fee includes instructional materials and food and beverage. For registrations received after 5:00 p.m. EST on May 24, 2014 include a $50 late fee. On-site registrations are payable only by credit card.

Total amount enclosed $ ____________

Payment Type:

JHU Faculty/Sta" Only: If you are using your Tuition Remission Bene!t or an ION budget, please complete this registration form and return with appropriate payment processing form to OCME, Turner 20. Forms can be found on-line at http://www.hopkinscme.edu/Resources/resources.aspx.

! Check (See instructions on top of form.)

! Credit Card: ! VISA ! MASTERCARD ! DISCOVER ! AMEX

Card # - - - ______________

Registration Form Course Number 80033341Updates in Recurrent Respiratory Papilloma: Clinical and Research Perspectives

May 30-31, 2014To Register: Online (credit card and eCheck): www.HopkinsCME.edu By fax: (866) 510-7088 By phone (credit card only): (410) 502-9634

Or mail this form to the Johns Hopkins University, O"ce of Continuing Medical Education, P.O. Box 64128, Baltimore, Maryland 21264-4128. Include check payable to HOPKINS/80033341, or include credit card information below

ACTIVITY CO#DIRECTORSLee Akst, MDAssistant Professor of Otolaryngology – Head and Neck Surgery Director, Johns Hopkins Voice Center Johns Hopkins University School of Medicine Baltimore, MarylandNazaneen Grant, MDAssistant Professor of Otolaryngology - Head and Neck Surgery Georgetown University HospitalWashington, DC

SPEAKERSClint Allen, MD Assistant Professor of Otolaryngology- Head and Neck SurgeryJohns Hopkins University School of MedicineBaltimore, Maryland

Simon Best, MDAssistant Professor of Otolaryngology- Head and Neck SurgeryJohns Hopkins University School of MedicineBaltimore, Maryland

Farrel Buchinsky, MDProfessor of SurgeryTemple University School of Medicine Associate Professor of Otolaryngology- - Head and Neck SurgeryDrexel University College of MedicinePhiladelphia, Pennsylvania

David Feller-Kopman, MDAssociate Professor of Medicine,Pulmonary and Critical Care MedicineDirector, Interventional Pulmonology Johns Hopkins University School of MedicineBaltimore, Maryland

Alexander Hillel, MDAssistant Professor of Otolaryngology- Head and Neck SurgeryJohns Hopkins University School of MedicineBaltimore, Maryland

Sara Pai, MD, PhDAssociate Professor, Center for Laryngeal Surgery and Voice RehabilitationMassachusetts General HospitalBoston, Massachusetts

Diego Preciado, MDAssistant Professor of Surgery and Pediatrics George Washington University School of Medicine and Health SciencesFaculty, OtolaryngologyChildren’s National Medical Center Washington, DC

C. Richard Schlegel, MDChairman and Professor, Department of PathologyLombardi Comprehensive Cancer CenterGeorgetown University HospitalWashington, DC

Bettie Steinberg, PhDProfessor and Dean, Elmezzi Graduate School of Molecular MedicineProfessor and Chair, Department of Molecular MedicineChief Scienti!c O"cerInvestigator, Center for Oncology and Cell BiologyDirector, Laboratory of Papilomavirus ResearchThe Feinstein Institute for Medical ResearchHofstra North Shore-LIJ School of Medicine Hempstead, New York

David Tunkel, MDProfessor of Pediatrics and Otolaryngology - Head and Neck Surgery Division Chief, Pediatric OtolaryngologyJohns Hopkins University School of MedicineBaltimore, Maryland

Jennifer Woo, MSPresident, Recurrent Respiratory Papillomatosis Foundation MD CandidateGeorgetown University School of Medicine Washington, DC

Hang Yuan, PhDAssistant Professor of Molecular Oncology Georgetown University HospitalWashington, DC

Steven Zeitels, MDChief, Center for Laryngeal Surgery and Voice RehabilitationMassachusetts General HospitalBoston, Massachusetts