CUSTOM SYNTHESIS In addition to our catalogue business we are offering custom synthesis from our UK based lab. With over 130 years of combined lab-based experience and 10 dedicated chemists, we can deal quickly and efficiently with your synthetic challenges and demands. We are specialised in unusual and highly functionalised aromatic compounds and late stage intermediates. INTRODUCTION OF FLUORINE AND FLUORINATED MOIETIES KF Exchange Balz-Schiemann Trifluoromethylation Difluoromethylation Perfluoroalkylation Nucleophilic Trifluoromethylation Deoxyfluorination Trifluoromethyl Sulphides/ Sulphones Difluoromethyl Sulphides/ Sulphones Fluorinated Alkoxylation Aryl-SF5 compounds TYPICAL REACTIONS TO SYNTHESISE BUILDING BLOCKS Oxidation Reduction Halogenation Alkylation Diazotisation Nitration Cyanation Cyclisation Grignard Reaction Lithiation Transition Metal-Catalysed Coupling Suzuki Coupling Sonogoshira Coupling Ullmann Reaction Buchwald- Hartwig CASE STUDY: SUPPORTING YOUR PROJECT FROM CONCEPTION TO COMMERCIAL REALISATION improved yield and purity 96+% improved purity of 99+% optimisation of difficult purification achieved 93+% purity GC analytical method developed and optimised to identify impurities <0.1% several impurities identified and synthesised to confirm structure 99+% purity on 22 kg scale in the UK labs scaled to 100 kg with partner Custom Synthesis starting from gram quantities up to 10kg scale (up to 20L reactors). Scale up of existing procedures. Via our partners we can offer up to multi-tonne scale. Optimisation of semi-bulk reactions. Literature searching and route optimisation. Short lead times and highly competitive pricing due to our 20,000 available stock items. £ Excellent on-time delivery record. Complete IP protection, confidentiality guaranteed. Written reports based on the requirements of our customers and frequent project updates. Fully characterised compounds, in house quality control. (LC-MS, HPLC, GC, IR and NMR). WE ARE OFFERING Apollo Scientific Ltd Whitefield Road, Stockport, Bredbury, Cheshire SK6 2QR. United Kingdom. tel: +44(0)161 406 0505 fax: +44(0)161 406 0506 email: custom.synthesis@apolloscientific.co.uk @ApolloSciUK visit: www.apolloscientific.co.uk WANT AN UNUSUAL AMINE FOR YOUR HIT TO LEAD PROGRAM? MULTIGRAMS OF A LATE STAGE INTERMEDIATE FOR YOUR PROJECTS? We can support your project from conception to commercial realisation and we would welcome your enquires.

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Page 1: apollo single page a4 flyer - chemie-brunschwig.ch · aromatic compounds and late stage intermediates. INTRODUCTION OF FLUORINE AND FLUORINATED MOIETIES ... Nitration Cyanation Cyclisation

CUSTOM SYNTHESISIn addition to our catalogue business we are offering custom synthesis from our UK based lab.

With over 130 years of combined lab-based experience and 10 dedicated chemists, we can deal quickly and effi ciently with your synthetic challenges and demands.

We are specialised in unusual and highly functionalised aromatic compounds and late stage intermediates.

INTRODUCTION OF FLUORINE AND FLUORINATED MOIETIES

KF ExchangeBalz-SchiemannTrif luoromethylationDifluoromethylationPerfluoroalkylationNucleophil ic Trif luoromethylationDeoxyfluorinationTrif luoromethyl Sulphides/SulphonesDifluoromethyl Sulphides/SulphonesFluorinated AlkoxylationAryl-SF5 compounds

TYPICAL REACTIONS TO SYNTHESISE BUILDING BLOCKS

OxidationReductionHalogenationAlkylationDiazotisationNitrationCyanationCyclisationGrignard ReactionLithiation

Transit ion Metal-Catalysed CouplingSuzuki CouplingSonogoshira CouplingUllmann ReactionBuchwald-Hartwig

CASE STUDY: SUPPORTING YOUR PROJECT FROM CONCEPTION TO COMMERCIAL REALISATION

improved yield and purity 96+%

improved purity of 99+%

optimisation of diffi cult purifi cation achieved

93+% purity

GC analytical method developed and optimised to

identify impurities <0.1%

several impurities identifi ed and synthesised to

confi rm structure99+% purity on 22 kg scale in the