Appendix 1 - ICD9 Mapping - ars.els-cdn.com€¦ · Web viewSupplementary material. Table of Contents. Appendix 1 - ICD9 Mapping2. Appendix 2 – Italian stop words used in the

Supplementary material

Table of ContentsAppendix 1 - ICD9 Mapping.....................................................................................................2

Appendix 2 – Italian stop words used in the ICD9-CM TM analysis.........................................15

Appendix 3 – English stop words used in the Remapped Procedures TM analysis...................16

Appendix 4 – TM on CCS remapped procedures.....................................................................17

Appendix 5 – Complete list of the extracted careflows and remapping into clusters..............19

Appendix 6– Grid search evaluation of CFM parameters........................................................23

Appendix 7–CFM only based histories (Admission and SPU events).......................................25

Appendix 1 - ICD9 MappingMapped Procedures Count of ICD9

CODESCount of

Observations

Lumpectomy 10 4102Plastic Reconstruction On The Breast 26 3413Injection Infusion Of Chemotherapeutic Substances 2 2436Operations on the hemic and lymphatic system 8 1995Cardiovascular System Procedures 7 1257Mastectomy 12 1134Microscopic examination 11 1104Operations on axillary lymph nodes 3 1043Injection Of Therapeutic Substance And Transfusion 22 839Other 20 672Biopsy 5 585Diagnostic Radiology 16 476Diagnostic Ultrasound - Metastases 1 364Rehabilitation 18 345General Surgery 54 289CAT MRI - Metastases 9 282Radioisotope Scan And Function Study - Metastases 5 224Plastic Surgery 13 165Diagnostic Ultrasound 5 156Operations On Respiratory System 11 123Therapeutic Radiology - Metastases 4 109Operations on the nervous system 14 103Operations On The Cardiovascular system 11 95Operation On Musculoskeletal System 10 59Endoscopic Procedure On Digestive System 11 55Diagnostic Radiology - Metastases 12 50Biopsy - Metastases 14 47Procedures Related To The Psyche 5 41Nervous System Procedures 6 34Hyperthermia for Cancer Treatment 2 19Operation On The Female Genital Organs 8 17Ophthalmologic And Otologic Procedures 4 15Operation On The Urinary System 6 9

Endoscopic Procedure On Digestive System - Metastases

2 5

Respiratory intubation and mechanical ventilation 1 2

PROCEDURE REMAPPING ICD9 - CODESBiopsy 06.11

40.1185.1185.1286.11

Biopsy - Metastases 33.2433.2633.2741.3145.2550.1150.1250.9152.1154.2354.2455.2377.4077.49

Cardiovascular System Procedures 88.7288.7789.4389.4489.5089.5289.54

CAT MRI - Metastases 87.0387.0487.4187.4288.0188.0288.3888.9188.93

Diagnostic Radiology 85.9188.9887.1187.1787.3787.4487.4987.6187.6287.6587.6987.7488.0388.1988.3489.53

Diagnostic Radiology - Metastases 87.2187.2287.2387.2487.2987.4388.2188.2688.2788.2888.2988.33

Diagnostic Ultrasound 88.7188.7388.7488.7588.79

Diagnostic Ultrasound - Metastases 88.76Endoscopic Procedure On Digestive System 44.13

45.1645.2345.4245.4351.8551.8854.2157.3257.3357.49

Endoscopic Procedure On Digestive System - Metastases 33.2233.23

General Surgery 00.6200.6404.3705.4406.8908.6440.4142.9243.4143.4943.9944.3944.9945.7345.7545.7645.9346.2146.5147.0147.1948.6348.7449.0149.1149.2949.3949.4950.2250.2951.1051.2251.2351.9853.0353.0453.1453.1753.2153.4153.4953.5153.5953.6154.5954.9154.9355.0370.52

Hypertermia For Cancer Treatement 93.3499.85

Injection Infusion Of Chemotherapeutic Substances 99.2599.28

Injection Of Therapeutic Substance And Transfusion 09.6639.9541.0141.0450.9483.9899.0099.0199.0399.0499.0599.1499.1599.1799.1899.1999.2199.2399.2499.2699.2999.52

Lumpectomy 85.2085.2185.2285.2385.2485.2585.8192.1692.1892.28

Mastectomy 39.9885.3385.3485.3585.3685.4185.4285.4385.4485.4585.4685.48

Microscopic examination 90.5390.5990.7991.0691.3191.3291.3391.4291.6691.8991.99

Nervous System Procedures 03.3189.1389.1489.1589.1789.19

Operation on Musculoskeletal System 77.6080.5981.9181.9283.3283.9188.3193.0893.1697.87

Operation On The Female Genital Organs 65.3165.4965.5365.6265.6368.2969.1989.26

Operation On The Urinary System 05.5405.9855.5156.3156.8196.49

Operations on axillary lymph nodes 40.2240.2340.51

Operations On Respiratory System 34.0934.9134.9389.3789.3889.6693.1893.9093.9193.9693.99

Operations On The Cardiovascularsystem 03.7038.5938.9138.9338.9538.9939.2739.5039.9086.0799.61

Operations on the hemic and lymphatic system 04.0304.0940.1940.2440.2940.5240.5340.59

Operations on the nervous system 00.3600.4203.5303.9003.9103.9203.9303.9403.9604.8004.8104.9905.3105.39

Ophthalmologic and Otologic Procedures 21.8640.2195.0295.03

Other 08.2308.6108.6308.8608.8708.9757.9489.0189.0289.0389.0589.0689.0789.0889.0989.6189.6593.0799.7999.84

Plastic Reconstruction On The Breast 85.8208.5683.4385.3185.3285.5085.5185.5385.5485.8585.8785.8985.9385.9485.9585.9686.0286.6386.6986.7086.7286.7586.8486.9388.9488.97

Plastic Surgery 86.6078.4986.0186.0486.0986.1986.2286.2386.2886.5986.8993.5796.59

Procedures Related To The Psyche 94.0994.1294.3794.3894.42

Radioisotope Scan And Function Study - Metastases 92.0192.0992.1492.1592.19

Rehabilitation 93.0193.0393.0993.1193.1293.1393.1493.1793.1993.2293.2793.3693.3893.3993.7493.8293.8394.63

Respiratory intubation and mechanical ventilation 96.70Therapeutic Radiology - Metastases 92.24

92.2592.2692.29

Appendix 2 – Italian stop words used in the ICD9-CM TM analysisList of stop words available in the R package topicmodels

[1] "ad" "al" "allo" "ai" "agli" "all" [7] "agl" "alla" "alle" "con" "col" "coi" [13] "da" "dal" "dallo" "dai" "dagli" "dall" [19] "dagl" "dalla" "dalle" "di" "del" "dello" [25] "dei" "degli" "dell" "degl" "della" "delle" [31] "in" "nel" "nello" "nei" "negli" "nell" [37] "negl" "nella" "nelle" "su" "sul" "sullo" [43] "sui" "sugli" "sull" "sugl" "sulla" "sulle" [49] "per" "tra" "contro" "io" "tu" "lui" [55] "lei" "noi" "voi" "loro" "mio" "mia" [61] "miei" "mie" "tuo" "tua" "tuoi" "tue" [67] "suo" "sua" "suoi" "sue" "nostro" "nostra" [73] "nostri" "nostre" "vostro" "vostra" "vostri" "vostre" [79] "mi" "ti" "ci" "vi" "lo" "la" [85] "li" "le" "gli" "ne" "il" "un" [91] "uno" "una" "ma" "ed" "se" "perché" [97] "anche" "come" "dov" "dove" "che" "chi" [103] "cui" "non" "più" "quale" "quanto" "quanti" [109] "quanta" "quante" "quello" "quelli" "quella" "quelle" [115] "questo" "questi" "questa" "queste" "si" "tutto" [121] "tutti" "a" "c" "e" "i" "l" [127] "o" "ho" "hai" "ha" "abbiamo" "avete" [133] "hanno" "abbia" "abbiate" "abbiano" "avrò" "avrai" [139] "avrà" "avremo" "avrete" "avranno" "avrei" "avresti" [145] "avrebbe" "avremmo" "avreste" "avrebbero" "avevo" "avevi" [151] "aveva" "avevamo" "avevate" "avevano" "ebbi" "avesti" [157] "ebbe" "avemmo" "aveste" "ebbero" "avessi" "avesse" [163] "avessimo" "avessero" "avendo" "avuto" "avuta" "avuti" [169] "avute" "sono" "sei" "è" "siamo" "siete" [175] "sia" "siate" "siano" "sarò" "sarai" "sarà" [181] "saremo" "sarete" "saranno" "sarei" "saresti" "sarebbe" [187] "saremmo" "sareste" "sarebbero" "ero" "eri" "era" [193] "eravamo" "eravate" "erano" "fui" "fosti" "fu" [199] "fummo" "foste" "furono" "fossi" "fosse" "fossimo" [205] "fossero" "essendo" "faccio" "fai" "facciamo" "fanno" [211] "faccia" "facciate" "facciano" "farò" "farai" "farà" [217] "faremo" "farete" "faranno" "farei" "faresti" "farebbe" [223] "faremmo" "fareste" "farebbero" "facevo" "facevi" "faceva" [229] "facevamo" "facevate" "facevano" "feci" "facesti" "fece" [235] "facemmo" "faceste" "fecero" "facessi" "facesse" "facessimo" [241] "facessero" "facendo" "sto" "stai" "sta" "stiamo" [247] "stanno" "stia" "stiate" "stiano" "starò" "starai" [253] "starà" "staremo" "starete" "staranno" "starei" "staresti" [259] "starebbe" "staremmo" "stareste" "starebbero" "stavo" "stavi" [265] "stava" "stavamo" "stavate" "stavano" "stetti" "stesti" [271] "stette" "stemmo" "steste" "stettero" "stessi" "stesse" [277] "stessimo" "stessero" "stando"

List of stop words added for the analysis presented in this paper

[1] "altra" "altre" "altro" "altri" "altrove" [6] "routine" "nas" "semplice" "strutture" "classificate" [11] "classificato" "microscopici" "sistema" "sostanza" "sostanze" [16] "determinazione" "diagnostica" "dinamico" "assiale" "computerizzata"[21] "farmaci" "apparato" "arteriosa" "arterioso" "venosa" [26] "venoso" "misto" "mista" "monitoraggio" "sistemica" [31] "periferico" "ossa" "cellule" "gruppo" "mammella" [36] "definito" "limitato" "invasive" "misure" "procedure" [41] "body" "total" "complessive" "definite" "generale" [46] "attivi" "passivi" "stato" "passo" "coltura"

[51] "approfondito" "esame" "accesso" "dispositivo" "limitate" [56] "continua" "positiva" "contemporaneo" "mediante" "occupazionale" [61] "matrice" "plica" "ungueale" "unghia" "dilatazione" [66] "esofago" "iniezione" "infusione"

Appendix 3 – English stop words used in the Remapped Procedures TM analysisList of stop words available in the R package topicmodels

[1] "i" "me" "my" "myself" "we" "our" [7] "ours" "ourselves" "you" "your" "yours" "yourself" [13] "yourselves" "he" "him" "his" "himself" "she" [19] "her" "hers" "herself" "it" "its" "itself" [25] "they" "them" "their" "theirs" "themselves" "what" [31] "which" "who" "whom" "this" "that" "these" [37] "those" "am" "is" "are" "was" "were" [43] "be" "been" "being" "have" "has" "had" [49] "having" "do" "does" "did" "doing" "would" [55] "should" "could" "ought" "i'm" "you're" "he's" [61] "she's" "it's" "we're" "they're" "i've" "you've" [67] "we've" "they've" "i'd" "you'd" "he'd" "she'd" [73] "we'd" "they'd" "i'll" "you'll" "he'll" "she'll" [79] "we'll" "they'll" "isn't" "aren't" "wasn't" "weren't" [85] "hasn't" "haven't" "hadn't" "doesn't" "don't" "didn't" [91] "won't" "wouldn't" "shan't" "shouldn't" "can't" "cannot" [97] "couldn't" "mustn't" "let's" "that's" "who's" "what's" [103] "here's" "there's" "when's" "where's" "why's" "how's" [109] "a" "an" "the" "and" "but" "if" [115] "or" "because" "as" "until" "while" "of" [121] "at" "by" "for" "with" "about" "against" [127] "between" "into" "through" "during" "before" "after" [133] "above" "below" "to" "from" "up" "down" [139] "in" "out" "on" "off" "over" "under" [145] "again" "further" "then" "once" "here" "there" [151] "when" "where" "why" "how" "all" "any" [157] "both" "each" "few" "more" "most" "other" [163] "some" "such" "no" "nor" "not" "only" [169] "own" "same" "so" "than" "too" "very"

List of stop words added for the analysis presented in this paper

[1] "system" "substance" "substances" "procedure" "procedures" [6] "operation" "operations" "general" "related" "microscopic"[11] "study" "function" "scan"

Appendix 4 – TM on CCS remapped proceduresUsing the same procedure described in the Methods section and applied to the ICD9-CM case, to choose the number of topics of the model we performed a grid search on K ranging from 2 to 13, and evaluated consistency, redundancy, importance, and perplexity. Consistency does not change with k, and it is always greater than 0.75. Redundancy is 0 up until K=6, never reaching values higher than 0.25. Importance slowly decreases between K=3 and K=7, with a steeper decrease from K=7. Perplexity shows a fast increase for K>7. In general, given the low number of words in the dictionary, models with higher number of topics over-describe the documents’ space.

a) b)

c) d)

Remapped procedures

TOPIC WORDS # Words TOPIC LABEL

1 axillarylymphnodes

3 Lymph nodes operations

2 plasticbreastreconstruction

3 Plastic

3 therapeuticmetastasestransfusiondiagnosticcardiovascular

10 Other exams and therapies

radiologyultrasoundotherrehabilitationexamination

4 injectionchemotherapeuticinfusion

3 Chemotherapy

5 lumpectomyhemiclymphatic

3 Lumpectomy

6 mastectomybiopsy

2 Mastectomy / Biopsy

Appendix 5 – Complete list of the extracted careflows and remapping into clusters

Cluster Event 1 Event 2 Event 3 Event 41 Lumpectomy;

prosthesisOUT OUT OUT

1 Mastectomy; prosthesis

OUT OUT OUT


Plastic; prosthesis

OUT OUT


Skin graft / Lymph nodes operations; skin

OUT OUT

1 Plastic; prosthesis

OUT OUT OUT


Plastic; prosthesis

OUT OUT



OUT OUT




OUT

1 Skin graft / Lymph nodes operations; skin

OUT OUT OUT



OUT OUT



Plastic; prosthesis

OUT




OUT




Plastic; prosthesis





1 Skin graft / Lymph nodes operations; prosthesis

OUT OUT OUT

2 Lumpectomy; removal

Chemotherapy; tumor

Chemotherapy; tumor

Chemotherapy; tumor

2 Lumpectomy; Chemotherapy; Chemotherapy; OUT

removal tumor tumor2 Lumpectomy;

removalChemotherapy; tumor

Day Hospital; SPU visit

OUT


Chemotherapy; tumor

Other exams and therapies; tumor

OUT


Chemotherapy; tumor

OUT OUT








OUT



OUT OUT


Lumpectomy; removal


OUT


Lumpectomy; removal

OUT OUT



Chemotherapy; tumor

OUT



OUT OUT

2 Lumpectomy; quadrantectomy



OUT



OUT OUT

2 Mastectomy; removal

Chemotherapy; tumor

Chemotherapy; tumor

OUT


Chemotherapy; tumor

OUT OUT




OUT



OUT OUT

2 Mastectomy; unilateral

Chemotherapy; tumor

Chemotherapy; tumor

OUT


Chemiotherapy; tumor

OUT OUT



OUT OUT



OUT OUT



OUT OUT

2 Skin graft / Lymph nodes operations; removal



OUT

2 Skin graft / Lymph nodes


OUT OUT

operations; removal




OUT



OUT OUT


Chemotherapy; tumor

Chemotherapy; tumor

Plastic; prosthesis



Plastic; prosthesis

OUT




Plastic; prosthesis



Plastic; prosthesis




Plastic; prosthesis

OUT


Plastic; prosthesis


OUT


Chemotherapy; tumor

Plastic; prosthesis

OUT


Lumpectomy; quadrantectomy

OUT OUT


Mastectomy; removal

OUT OUT


Mastectomy; unilateral

OUT OUT


Lumpectomy; removal

OUT OUT


Lumpectomy; quadrantectomy

OUT OUT


Plastic; prosthesis

OUT OUT


Skin graft / Lymph nodes operations; removal

OUT OUT



OUT OUT




OUT


Plastic; prosthesis

OUT OUT


Plastic; prosthesis

Plastic; reconstruction

OUT


Plastic; prosthesis

Skin graft / Lymph nodes

OUT

operations; skin5 Mastectomy;

removalPlastic; prosthesis




Plastic; prosthesis

OUT OUT


Plastic; prosthesis

Plastic; reconstruction

OUT


Plastic; prosthesis


OUT

6 Day Hospital; SPU visit

Lumpectomy; removal

OUT OUT


Mastectomy; removal


OUT


Mastectomy; removal

OUT OUT


OUT OUT OUT


Skin graft / Lymph nodes operations; removal

OUT OUT


Other exams and therapies; exercises

OUT OUT


Other exams and therapies; exercises

OUT OUT

8 Chemiotherapy; biopsy

OUT OUT OUT


OUT OUT OUT


OUT OUT OUT


OUT OUT OUT


OUT OUT OUT


OUT OUT OUT


Other exams and therapies; ultrasound

OUT OUT


Other exams and therapies; exams

OUT OUT

Appendix 6 – Grid search evaluation of CFM parameters CFM algorithm parameters were selected following the grid-search approach presented in Section 2.3. In particular, we performed a grid search by varying min_support in the range 2-50 and max_length in the range 3-10. The Figure below shows a heatmap with the corresponding values for the number of careflows, the average number of patients per careflow, the average number of missed events, and the true match rate for each value of the pair of parameters min_support and max_length.Red values should be avoided, choosing minimum support and maximum history length accordingly. As can be seen from red boxes on heatmap, some indicators need to be maximized (true match rate and mean number of patients per careflow), and other to be minimized (number of mined careflows, mean number of missed events). The last heatmap reports a normalized score that combines all four parameters. All the single indicators have been normalized on a scale from 0 to 1, where 0 corresponds to the old red box values and 1 to the lighter values. The normalized values are combined together using the mean. As seen in the last heatmap, the best score is reached in the interval between 5 and 10 events for minimum_support and a maximum_history_length larger than 5 events. Choosing 10 as minimum support allows deriving less than one hundred histories.

Appendix 7–CFM only based histories (Admission and SPU events) History Regrouping

History HistEvents Recode

Hist_1_SubHist_9 _SPUBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT H0

Hist_1_SubHist_3 _SPUBreastSurgery_OUT_OUT_OUT_OUT_OUT_OUT H0

Hist_1_SubHist_4 _SPUOncology_OUT_OUT_OUT_OUT_OUT_OUT H0

Hist_1_SubHist_2 _AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT_OUT H1

Hist_1_SubHist_17 _AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT H2

Hist_1_SubHist_14 _AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT H2

Hist_1_SubHist_10 _AdmissionBreastSurgery_AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT H2

Hist_1_SubHist_5 _AdmissionBreastSurgery_AdmissionBreastSurgery_OUT_OUT_OUT_OUT_OUT H2

Hist_1_SubHist_11 _AdmissionBreastSurgery_AdmissionBreastSurgery_SPUOncology_OUT_OUT_OUT_OUT H2

Hist_1_SubHist_6 _AdmissionBreastSurgery_AdmissionOncology_OUT_OUT_OUT_OUT_OUT H3

Hist_1_SubHist_7 _AdmissionBreastSurgery_SPUBreastSurgery_OUT_OUT_OUT_OUT_OUT H4

Hist_1_SubHist_8 _AdmissionBreastSurgery_SPUOncology_OUT_OUT_OUT_OUT_OUT H5

Hist_1_SubHist_13 _AdmissionBreastSurgery_SPUOncology_SPUOncology_OUT_OUT_OUT_OUT H5

Hist_1_SubHist_16 _AdmissionBreastSurgery_SPUOncology_SPUOncology_SPUOncology_OUT_OUT_OUT H5

Hist_1_SubHist_18 _AdmissionBreastSurgery_SPUOncology_SPUOncology_SPUOncology_SPUOncology_OUT_OUT H5

Hist_1_SubHist_12 _AdmissionBreastSurgery_SPUOncology_AdmissionBreastSurgery_OUT_OUT_OUT_OUT H6

Hist_1_SubHist_15 _AdmissionBreastSurgery_SPUOncology_SPUOncology_AdmissionBreastSurgery_OUT_OUT_OUT H6

Phenotypes – Table 1

Hisotry H0 H1 H2 H3 H4 H5 H6

Number of patients 160 1513 706 51 65 604 247

Age 55.7(14.0) 63.1(13.0) 52.7(11.6) 66.1(13.0)

59.2(13.9) 58.6(12.2) 50(10.7)

Type of Surgery

Lumpectomy99(61.88)

1329(87.84) 287(40.65) 34(66.67) 38(58.46) 479(79.3) 62(25.1)

Mastectomy61(38.12)

184(12.16) 419(59.35) 17(33.33) 27(41.54) 125(20.7) 185(74.9)

Histological Type

DCIS In situ cancer 25(15.62)

170(11.24) 116(16.43) 5(9.8) 9(13.85) 6(0.99) 6(2.43)

CDI Invasive ductal cancer120(75)

1090(72.04) 464(65.72) 38(74.51) 39(60) 511(84.6) 195(78.95)

CLI Invasive lobular cancer15(9.38)

253(16.72) 126(17.85) 8(15.69) 17(26.15) 87(14.4) 46(18.62)

Grading

G125(15.62)

272(17.98) 91(12.89) 6(11.76) 6(9.23) 16(2.65) 11(4.45)

G287(54.37)

965(63.78) 432(61.19) 30(58.82) 38(58.46) 268(44.37) 114(46.15)

G348(30)

276(18.24) 183(25.92) 15(29.41) 21(32.31) 320(52.98) 122(49.39)

Neoadjuvant chemotherapy

No85(53.12)

1407(92.99) 642(90.93) 39(76.47) 61(93.85) 525(86.92) 213(86.23)

Yes74(46.25)

88(5.82) 60(8.5) 12(23.53) 2(3.08) 70(11.59) 31(12.55)

Unknown1(0.62)

18(1.19) 4(0.57) 0(0) 2(3.08) 9(1.49) 3(1.21)

Cancer multifocality

NO121(75.62)

1230(81.3) 471(66.71) 38(74.51) 47(72.31) 468(77.48) 153(61.94)

Yes39(24.38)

283(18.7) 235(33.29) 13(25.49) 18(27.69) 136(22.52) 94(38.06)

Staging

Stage 054(33.75)

201(13.28) 128(18.13) 6(11.76) 10(15.38) 28(4.64) 12(4.86)

Stage 163(39.38)

925(61.14) 343(48.58) 21(41.18) 30(46.15) 221(36.59) 67(27.13)

Stage 222(13.75)

333(22.01) 181(25.64) 12(23.53) 20(30.77) 236(39.07) 104(42.11)

Stage 321(13.12)

54(3.57) 54(7.65) 12(23.53) 5(7.69) 119(19.7) 64(25.91)

Biomolecular subtype

Luminal A69(43.12)

1048(69.27) 400(56.66) 28(54.9) 38(58.46) 152(25.17) 88(35.63)

Luminal B52(32.5)

366(24.19) 213(30.17) 17(33.33) 19(29.23) 279(46.19) 98(39.68)

Her2+27(16.88)

17(1.12) 31(4.39) 2(3.92) 0(0) 71(11.75) 27(10.93)

TNBC12(7.5)

82(5.42) 62(8.78) 4(7.84) 8(12.31) 102(16.89) 34(13.77)

Hormone therapy

NO60(37.5)

250(16.52) 143(20.25) 16(31.37) 14(21.54) 213(35.26) 71(28.74)

Yes100(62.5)

1263(83.48) 563(79.75) 35(68.63) 51(78.46) 391(64.74) 176(71.26)

Chemotherapy

NO64(40)

1341(88.63) 480(67.99) 27(52.94) 52(80) 90(14.9) 30(12.15)

Yes96(60)

172(11.37) 226(32.01) 24(47.06) 13(20) 514(85.1) 217(87.85)

Radiotherapy

NO74(46.25)

328(21.68) 412(58.36) 17(33.33) 28(43.08) 103(17.05) 126(51.01)

Yes86(53.75)

1185(78.32) 294(41.64) 34(66.67) 37(56.92) 501(82.95) 121(48.99)

Lipofilling intervention

No142(88.75)

1496(98.88) 425(60.2) 46(90.2) 55(84.62) 579(95.86) 164(66.4)

Yes18(11.25)

17(1.12) 281(39.8) 5(9.8) 10(15.38) 25(4.14) 83(33.6)

Local/loco-regional recurrence (Yes) 18(11.25) 14(0.93) 76(10.76) 2(3.92) 8(12.31) 40(6.62) 37(14.98)

Metastasis - Distant recurrence (Yes)

32(20) 18(1.19) 38(5.38) 8(15.69) 6(9.23) 115(19.04) 43(17.41)

Exitus (Yes) 18(11.25) 15(0.99) 27(3.82) 16(31.37) 5(7.69) 68(11.26) 27(10.93)

Loco-Regional Recurrence – Survival (disease-free) curves – time in months

Distant Metastasis - survival (disease-free) curves

Death – survival curves

Documents

Appendix 1 - ICD9 Mapping - ars.els-cdn.com€¦ · Web viewSupplementary material. Table of Contents. Appendix 1 - ICD9 Mapping2. Appendix 2 – Italian stop words used in the