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Aqua Pharmaceuticals, LLC
Company Overview
Specialty dermatology pharmaceutical company currently focusing on acquiring, developing and marketing prescription medical dermatology products
Privately held; Founded in 2004
Focus on under or non-promoted, branded dermatology drugs in US Market
Stable and growing base business with high margins and strong cash flows
Commercial infrastructure with track record of success Sales coverage in all major, high-value targets in US (80% of +13,000 writers)
Comprehensive Management Team with two sales forces
+RoundTable made a controlling investment in June 2010
2
RoundTable Overview Operating-oriented investment approach
200+ years of expertise in medical product/devices, pharmaceuticals, and distribution
Equity partnerships with management teams
Particular focus on private, family companies and owner/founders
$1.9 billion in private equity buyout funds Fund I - $400 million private equity buyout fund raised in March 2002
Fund II - $500 million private equity buyout fund raised in March 2005
Capital Fund - $200 million subordinated debt investment fund raised in July 2006
Fund III - $600 million private equity buyout fund raised in July 2010
Capital Fund II - $200 million subordinated debt investment fund raised in July 2010
AMI Holdings, Inc.
Ascent Sabex AMIH MedAssist Argon Excelsior Clinical
Investment Date Sep-01 Apr-02 Apr-03 May-03 / Nov-04 Dec-03 Jun-04 Apr-05
Business reprocessor of injectable medical devices eligibility and vascular devices drug delivery OB/GYN devices
medical devices generic pharma and products A/R services products
Private or Public Owner Private Private Private Private Private Private Private
Founder/CEO Founder/CEO Family Founder/CEO Founders Founder/CEO Founders
RoundTable Initial Ownership 70%(a)
80% 65% 70% 87% 80% 87%
Rollover Retained Ownership 30% 20% 35% 30% 13% 20% 13%
Exit Return 8.3x 8.2x 7.2x 4.8x -- -- --
Avalign CorePharma Bioniche Aspen Vesta Aqua BVI
Investment Date Oct-05 / Jan-07 / Aug-05 Jan-06 / May-06 / Sep-06 / Jul-10 Aug-07 / Mar-09 Jun-10 Jul-10
Aug-07 / Apr-09 Dec-06 / May-07
Business surg. instruments solid dose injectable surgical medical specialty ophthalmic medical
and implants, generic pharma generic pharma products devices dermatology devices
case / tray systems
Private or Public Owner Private Private Public Sub. Private Private Private Public Sub.
Founder/Family Founders Public Co. & VC Founder/CEO Founder/CEO Founder/CEO Public Co.
RoundTable Initial Ownership 65% 80% 72%(b)
80% 80% 83% 91%
Rollover Retained Ownership 35% 20% 28% 20% 20% 17% 9%
Exit Return -- -- -- -- -- -- --
(a) RoundTable's current ownership is approximately 31% due to the merger with Alliance Medical Corp
(b) RoundTable's current ownership is approximately 83% due to the purchase of BLSI's 10% ownership stake
Incision & Healing Technologies
MEDASSIST
RoundTable Portfolio Companies
Strength in Aqua Management
Jay Gooding, Co-Founder, Chief Executive Officer
Nearly 30 years in Dermatology
Stiefel Laboratories – Sales, Training & Management
Healthpoint – Manager of Marketing & Product Development
Bioglan – Vice President of Marketing & Managed Care, Officer
Craig Ballaron, Co-Founder, President, Treasurer and Secretary
Nearly 30 years in Senior Management
Ultra Precision – President
Bioglan - Senior Vice President, Sales & Finance / CFO
David H. Crean, Ph.D., Vice-President, Corporate Development
+20 Years in Specialty Pharmaceuticals
Allergan, Inc. – Business Development for Dermatology, Neurology and
Ophthalmology
Allergan, Inc. – Project and Portfolio Management, Research & Development
5
Ted W. White, Vice-President, Sales
+20 Years in Sales & Marketing Leadership
Novartis – Managing Director – Primary Care, US Group Practice,
Cardiovascular
Skip Williams, Vice-President, Product Development
+20 Years in Specialty Pharmaceuticals
Watson Pharmaceuticals – Business Development – Nephrology, Dermatology,
Biologics
Accenture, System Software Associates, and Lexis-Nexis
Kimberley Forbes-McKean, Ph.D., Vice-President, Research & Development
+20 Years in Specialty Pharmaceuticals
Dermik / Sanofi-Aventis- Global Development
Cutanea Life Sciences and Isolagen, Inc.- CSO/ CTO, Development
Fragmented U.S. market with increased consolidation in 2011
6
2011 IMS Health All Topical, Tetracycline Antibiotics , Isotretinoins
$0
$200,000
$400,000
$600,000
$800,000
$1,000,000
$1,200,000
Ne
t Sa
les
$0
00
, All
MD
's
IMS 2011 Net Sales by Manufacturer >$50MM
Current Commercial Markets
Aqua has leading branded prescription drugs in four therapeutic categories including
acne, steroid-responsive dermatoses, seborrheic dermatitis and actinic keratosis
Acne market represents largest segment of overall dermatology market
• Sales of prescription and over-the-counter acne medications generate approximately $5 billion annually
• 15-20% of all consultations in dermatology related to acne
Topical corticosteroid market is estimated at $500+ million
• Indications include atopic dermatitis, contact dermatitis and psoriasis
Seborrheic dermatitis market
• Affects 1-3% of the immunocompetent adults
• 1.3MM uses in 2010 (OTC, Rx)
AK market (actinic keratoses) pre-cancer skin condition: estimated 10 million people affected in
the U.S.
• Estimated that 10% of AK advances to a cancerous state
• Favorable market dynamics with aging population
7
Recent New Product Addition
January 9, 2012
West Chester-based Aqua Pharmaceuticals,
LLC today announced the acquisition of
FLUOROPLEX® (fluorouracil) 1% Topical
Cream from Allergan, Inc.
FLUOROPLEX® is a topical cream indicated for the treatment of multiple actinic (solar) keratoses (small red or skin
color growths) that appear as a result of overexposure to the sun. Aqua will assume control of all manufacturing and
distribution, as well as promotion of the product through its own national dermatology focused sales force.
“Since early 2009, we have co-promoted the product with our partner, Allergan. We% are even more excited to have
full rights to FLUOROPLEX® in our product line”, said Jay Gooding, CEO for Aqua. The prescription product
complements the existing line of CORDRAN® (flurandrenolide) topical steroids, MONODOX® (doxycycline
Monohydrate capsules) oral antibiotics, and XOLOGEL® (ketoconazole USP) Gel, 2%.
AQUA PHARMACEUTICALS, LLC 8
Revenue Generating Products
9
Acne
Steroid-responsive
Dermatoses
Actinic
Keratoses
Market Product
Seborrheic
dermatitis
Monodox
Active
Doxycycline,
Oral
Cordran Flurandrenolide,
topical
Ketoconazole,
topical
Xolegel
5-Fluorouracil,
topical
Fluoroplex
Corporate Growth Strategy
Value creation is fueled through Four-Part approach
10
Maximize Current Product Growth and Profit
Facilitate long term growth through R&D Pipeline and Product Development
Strategic Collaborations
Acquire Companies and new products to expand product mix and core competencies
Existing
Brands New
Products
Partnerships Acquisitions
Business Development Initiatives
11
Dermatology assets for North America (US & Canada)
Therapeutic, Aesthetic, Physician Dispensed, OTC
No DESI products, No Novel NCE’s
Brands, not generics (unless unique opportunity exists)
Revenue-producing marketed assets
Open to Corporate M&A to add greater capabilities
drug 505(b)(2) higher probability projects
Assets with patents or market/ regulatory exclusivity
Aqua is looking for assets to add to its existing portfolio
Avoid capital equipment or “box plug-in” technology
Late stage (Phase II and beyond) development stage assets for longer term growth
Dermatological Areas of Interest
Acne Oral
Topical
Rosacea
Steroid Responsive Dermatoses
Psoriasis
Fungal Infections / seborrheic dermatitis
Actinic Keratoses / Precancerous conditions
AQUA PHARMACEUTICALS 12
Positioned for Future Growth
• Experienced team
• Growing capabilities
• Discipline and focus
• Well known, stable brands
• Sales and Marketing footprint
• Relationships with physicians and partners
• Financial investments
Aqua Pharmaceuticals, LLC