Are You suprised ?220.225.200.252/photoupload/syllabus/sybt.old.doc · Web viewQ I - 8 short type questions of 5 marks, 2 from each module Q II - 2 questions A and B of 15marks from

UNIVERSITY OF CALICUTFaculty of Engineering

Curriculum, Scheme of Examinations and Syllabi for B.Tech Degree Programme with effect from Academic Year 2000-2001

BT : Biotechnology Engineering

COMBINED FIRST AND SECOND SEMESTER

Code Subject Hours/Week Sessional Marks

University Examination

L T P/D Hrs MarksEN2K 101 Engineering Mathematics I 3 - - 50 3 100EN2K 102 Engineering Mathematics II 3 - - 50 3 100EN2K 103A Engineering Physics(A) 2 - - 50 3 100EN2K 103A(P) Physics Lab(A) - - 1 25 - -EN2K 104A Engineering Chemistry(A) 2 - - 50 3 100EN2K 104A(P) Chemistry Lab(A) - - 1 25 - -EN2K 105 Humanities 2 - - 50 3 100EN2K 106A Engineering Graphics(A) 1 - 3 50 3 100EN2K 107A Engineering Mechanics(A) 2 1 - 50 3 100EN2K 108 Computer Programming in C 2 1 - 50 3 100EC2K 109 Basic Electrical Engineering 2 1 - 50 3 100EC2K 110(P) Mechanical Workshop - - 2 50 - -EC2K 111(P) Electrical & Electronics

Workshop- - 2 50 - -

TOTAL 19 3 9 600 - 900

Note: Details of common courses are shown in the syllabus

University of Calicut Biotechnology Engineering

EN2K 101 : MATHEMATICS I(common for all B. Tech. programmes)

3 hours lecture per week

Module I: Differential Calculus (15 hours)Indeterminate forms - L` hospital`s rule - Radius of curvature - Centre of curvature - Evolute - Functions of more than one variable - Idea of partial differentiation - Euler`s theorem for homogeneous functions - Chain rule of partial differentiation - Applications in errors and approximations - Change of variables - Jacobians - Maxima and minima of functions of two or more variables - Method of Lagrange multipliers

Module II: Infinite Series (15 hours)Notion of convergence and divergence of infinite series - Ratio test - Comparison test - Raabe`s test - Root test - Series of positive and negative terms - Idea of absolute convergence - Test for alternating series - Power series - Interval of convergence - Taylors and Maclaurins series representation of functions - Leibnitz formula for the nth derivative of the product of two functions - Use of Leibnitz formula in the Taylor and Maclaurin expansions

Module III: Matrices (21 hours)Concept of rank of a matrix -Reduction of a matrix to echelon and normal forms - System of linear equations - Consistency of linear equations - Gauss` elimination - Homogeneous linear equations - Fundamental system of solutions - Inverse of a matrix - Solution of a system of equations using matrix inversion - Eigen values and eigen vectors - Cayley-Hamilton theorem - Eigen values of Hermitian, skew-Hermitian and unitary matrices - quadratic forms - Matrix associated with a quadratic form - Technique of diagonalization using row and column transformations on the matrix - Definite, semidefinite and indefinite forms – Their identification using the eigen values of the matrix of the quadratic form

Module IV: Fourier series and harmonic analysis (15 hours)Periodic functions - Trigonometric series - Fourier series - Euler formulae - Even and odd functions - Functions having arbitrary period - Half range expansions - Approximation by trigonometric polynomials - Minimum square error - Numerical method for determining Fourier coefficients - Harmonic analysis

Reference books1. Piskunov N., Differential and Integral calculus, MIR Publishers2. Wylie C.R., Advanced Engineering Mathematics, McGraw Hill3. Ayres F., Matrices, Schaum's Series, McGraw Hill4. Kreyszig E., Advanced Engineering Mathematics, Wiley Eastern5. Thomas G.B., Calculus and Analytic Geometry, Addison Wesley

Sessional work assessmentAssignments 2x10 = 202 tests 2x15 = 30Total marks = 50

University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15marks from module III with choice to answer any oneQ V - 2 questions A and B of 15marks from module IV with choice to answer any one


EN2K 102 : MATHEMATICS II(common for all B. Tech. programmes)


Module I: Ordinary differential equations (21 hours)A brief review of the methods of solutions of first order equations - Separable, homogeneous and linear types - Exact equations - Orthogonal trajectories - General linear second order equations - Homogeneous linear equation of the second order with constant coefficients - Fundamental system of solutions - Method of variation of parameters - Cauchy's equation - Simple applications of differential equations in engineering problems, including problems in mechanical vibrations, electric circuits and bending of beams

Module II: Laplace transforms (15 hours)Gamma and Beta functions – Definitions and simple properties - Laplace transform - Inverse transform – Laplace transform of derivatives and integrals - Shifting theorems - Differentiation and integration of transforms - Transforms of unit step function and impulse function - Transform of periodic functions - Solution of ordinary differential equations using Laplace transforms

Module III: Vector differential calculus (15 hours)Vector function of single variable - Differentiation of vector functions - Scalar and vector fields - Gradient of a scalar field - Divergence and curl of vector fields - Their physical meanings - Relations between the vector differential operators

Module IV: Vector integral calculus (15 hours)Double and triple integrals and their evaluation - Line, surface and volume integrals - Green`s theorem - Gauss` divergence theorem - Stokes` theorem (proofs of these theorems not expected) - Line integrals independent of the path

Reference books1. Wylie C.R., Advanced Engineering Mathematics, McGraw Hill2. Spiegel M.R., Vector Analysis, Schaum Series, McGraw Hill3. Kreyszig E., Advanced Engineering Mathematics, Wiley Eastern4. Thomas G.B., Calculus and Analytic Geometry, Addison Wesley

Sessional work assessmentAssignments 2x10 = 20 2 tests 2x15 = 30Total marks = 50



EN2K 103A : ENGINEERING PHYSICS(A)(common for AI, CS, EE, EC, IT, IC, PT)


Module I (11 hours)Interference of light - Interference from plane parallel thin films - Colours of thin films by reflected light - Newtons rings - Measurement of wave length - Thin wedge shaped air film - Air wedge - Testing of optical planes of surfaces - Diffraction of light - Introduction of Fresnel and Fraunhofer diffraction - Distinction between the two diffractions - Simple theory of plane transmission grating - Polarisation of light - Double refraction - Nicol prism - Quarter and half wave plates - Production and detection of elliptically and circularly polarised light - Rotatory polarisation - Lawrent’s half shade Polarimeter - Applications of polarised light

Module II (11 hours)Quantum mechanics - Newtonian mechanics and quantum mechanics - The wave function - Schrodinger’s wave equation for free particle - Potentials in Schrodinger equation - Time dependent Schrodinger equation - Time independent Schrodinger equation - Expectation values - Derivation of Schrodinger equation -Application - Particle in a box (motion in one dimension) - Ultrasonics - Piezo effect - Piezo electric crystal production and detection of ultrasonics - Applications of ultrasonics - NMR and ESR - Basic principles of Nuclear Magnetic Resonance (NMR) and Electron Spin Resonance (ESR) - Experimental method for detection of NMR and ESR - Applications

Module III (11 hours)Laser physics - Basic concepts of laser - Spontaneous and stimulated emission - Absorption - Population inversion - Optical pumping - Construction and components of laser - Ruby laser - Helium - Neon laser and semiconductor laser - Applications - Basic principle of holography and its application - Fibre optics - Basic principle - Fibre constructions - Fibre dimensions - Light propagation in fibre - Signal distortion in optical fibres and transmission losses (brief ideas only) - Light wave communication using optical fibres and its advantages - Applications

Module IV (11 hours)Semiconductor physics - Energy band diagrams - Classifications of semiconductors on the basis of Fermi level and Fermi energy - Impurity level in N-type and P-type semiconductors - Applications of semiconductors - Zener diode, light emitting diode, solar cell, phototransistor, photo resister (LDR) - Hall effect introduction - Measurement of hall voltage and hall coefficient - Importance of hall effect - Super conductivity - Properties of superconductors - Josephson effect and tunnelling (qualitative) - BCS theory of superconductivity (qualitative) - Applications of superconductivity

Text and reference books1. Sreenivasan, M .R, Physics for Engineers, New Age International 2. Vasudeva, A.S; Modern Engineering Physics, S. Chand 3. Brijlal & Subrahmanyam, N, Text book of Optics, S.Chand 4. Jenkins, F.A & White, H.E, Fundamentals of Optics, McGraw Hill5. Kale Gokhale; Fundamentals of Solid State Electronics, Kitab Mahal6. Gupta, S. L & Kumar, V; Solid State Physics, K.Nath 7. Srivastva, C. M.& Srinivasan, C; Science of Engineering Materials, New Age International8. Rajam, J. B; Modern Physics, S. Chand




EN2K 103A(P) : PHYSICS LAB(A)(common for AI, EE, EC, IC)

1 hour lab per week or 2 hours lab per alternate weeks

List of experiments (Any 10 experiments should be given)1. Refractive index of a liquid using hollow prism and spectrometer2. Wavelength of mercury spectral lines using diffraction grating and spectrometer3. Ordinary and extraordinary refractive indices (µO and µe) of calcite (or quartz) using spectrometer and

sodium light4. Thickness of a wire using optical bench5. Radius of curvature of convex lens by Newton’s rings method6. Diameter of a wire by Air-wedge method7. Specific rotation of cane sugar solution using polarimeter8. Velocity and Wavelength of ultrasonics using ultrasonic diffractometer9. Band gap energy in a semiconductor using a reversed biased p-n junction10. Hall effect in a semi conductor11. Characteristic of Light Dependent Resistor (LDR)12. Characteristic of a Light Emitting Diode (LED)13. Characteristic of a zener diode14. Characteristic of a phototransistor15. Divergence of laser beam using He=Ne Laser16. Wavelength of laser light with a transmission grating17. Measurement of numerical aperture and attenuation in optical fibres18. Measurement of displacements using fibre optic sensor

Reference books1. Gupta, S.L & Kumar, V, Practical Physics with Viva-voce, Pragati Prakashan2. Avadhanulu, M. N, Dani, A. A & Pokley, P. M; Experiments in Engineering Physics, S.Chand

Sessional work assessmentLab practicals and record = 15Test/s = 10Total marks = 25


EN2K 104A : ENGINEERING CHEMISTRY(A)(common for AI, CS, EE, EC, IT, IC, PT)


Module I (13 hours)Structure of solids - Geometry of crystalline solids - Space lattices - Crystal structure - Bragg's law of X-ray diffraction - Covalent solids - Ionic solids - Metals and alloys - Noncrystalline states - Crystal imperfections - Point defects – Dislocations - Conductors and resistors - Free electron theory - Super conductors - Semiconductors - Intrinsic and extrinsic - Semiconductor materials and their fabrication - Liquid crystals - Dielectric materials - Polarization - Feroelectric materials

Module II (9 hours)Electrochemistry - Electrode potentials - Types of electrodes - Salt bridge - emf measurement - Concentration cells - Acids and bases - Buffer solutions - pH measurement - Glass electrode - Polarization - Over voltage - Secondary cells and fuel cells

Module III (9 hours)Corrosion - Protective coatings and pollution - Dry corrosion - Oxidation processes - Wet corrosion - Electrochemical theory - Different forms of corrosion - Prevention and control - Protective coating - Pretreatment of surface - Metallic and nonmetallic coatings - Electro deposition - Cementation - Metal spraying - Air pollution - Types - Causes - Power generation pollution - Thermal pollution - Petrochemical smog - Methods of control

Module IV (13 hours)High polymers and lubricants - Polymerisation and functionality - Chain, condensation and copolymerisation - Mechanism - Coordination polymerisation - Polymerisation processes - Structure, properties and molecular weight of polymers - Thermosetting and thermoplastics materials - Application in electrical and electronic industries - Elastomers - Vulcanization - Synthetic rubbers - Lubricants - Theory of friction - Mechanisms of lubrication - Classification and properties of lubricants - Additives - Synthetic lubricants - Solid lubricants

Reference books1. Kuriakose J. C & Rajaram J, Chemistry in Engineering and Technology Vols 1 & 2, Tata McGraw Hill2. Raghavan V, Materials Science and Engineering - A First Course, Prentice Hall3. Sawyer C. N & McGarpy P L, Chemistry for Environmental Engineering, McGraw Hill




EN2K 104A(P) : CHEMISTRY LAB(A)(common for AI, EE, EC, IC)

1 hour lab per week or 2 hours lab per alternate weeks

List of experiments

1. Estimation of copper in a given sample of brass

2. Estimation of Iron in a given sample of iron ore

3. Estimation of total hardness of a given sample of water using EDTA solution

4. Determination of chloride ions in a sample of water for domestic use

5. Determination of dissolved oxygen present in given water sample (Winkler's method)

6. Determination of flash point and fire point of a given oil by Pensky Martens flash point apparatus

7. To prepare buffers and standardisation of pH meter

8. Determination of molarity of HCI pH - metrically, provided M/10 Na OH

9. Preparations of urea formaldehyde resin and phenol formaldehyde resin (Bakelite)


EN2K 105 : HUMANITIES(common for all B. Tech. programmes)


Module I (10 hours)Introduction to English usage and grammarReview of grammar - Affixes, prefixes, suffixes, participles and gerunds - Transformation of sentences - Commonly misspelt words - Correction of mistakes - Punctuation - Idioms - Style - Vocabulary buildingReading comprehensionExposure to a variety of reading materials, articles, essays, graphic representation, journalistic articles, etc.Writing comprehensionSkills to express ideas in sentences, paragraphs and essays

Module II (10 hours)Technical communication and report writingGrowing need and importance of technical communication - aspects of technical description of machinery, equipment and processes - Giving instructions in an industrial situation - Note taking and note making - Correspondence on technical topics - Different types of technical reports

Module III (10 hours)Humanities in a technological ageImportance of humanities to technology, education and society - Relation of career interests of engineers to humanities - Relevance of a scientific temper - Science, society and culture Introduction to writings of modern thinkers on society and cultureTechnologyHistorical concepts and current usage (This module should be a window to the world of western and eastern mind with an emphasis on exposition of topical ideas through coherent language)


Module IV (14 hours)History of science and technologyScience and technology in the primitive society - Development of science and technology in early civilised societies - Science and classical Greece - The rise and development of early Indian science - Contributions of the Arabs to science and technology - European science and the revolutionary (industrial, American and French revolutions) era - Recent advances in Indian science

Reference books1. Huddleston R, English Grammer - An outline, Cambridge University Press2. Pennyor, Grammar Practice Activities, Cambridge University Press3. Murphy, Intermediate English Grammar, Cambridge University Press4. Hashemi, Intermediate English Grammar - Supplementary Exercises with answers", Cambridge

University Press5. Vesilind; Engineering, Ethics and the Environment, Cambridge University Press6. Larson E; History of Inventions, Thompson Press India Ltd.7. Bernal J. D, Science in History, Penguin Books Ltd.8. Dampier W. C, History of Science", Cambridge University Press9. Encyclopedia Britannica, History of Science, History of Technology10. Subrayappa; History of Science in India, National Academy of Science, India.11. Brownoski J, Science and Human Values, Harper and Row12. Schrodinger, Nature and Greeks and Science and Humanism, Cambridge University Press13. Bossel, H, Earth at a Crossroads – paths to a sustainable Future, Cambridge University Press14. McCarthy, English Vocabulary in Use, Cambridge University Press



EN2K 106A : ENGINEERING GRAPHICS(A)(common for AI, CS, EE, EC, IT, IC, PT)

1 hour lecture and 3 hours drawing

Module 0 (12 hours - 1 drawing exercise)Introduction to engineering graphics - Drawing instruments and their uses - Different types of lines - Lettering and dimensioning - Familiarisation with current Indian standard code of practice for general engineering drawing - Construction of ellipse, parabola and hyperbola. Construction of cycloid, involute and helix (Only practice, no University examination)

Module I (18 hours - 3 drawing exercises)a) Introduction to orthographic projections - Vertical, horizontal and profile planes - Principles of first angle and third angle projections - Projections of points in different quadrants - Orthographic projections of straight lines parallel to one plane and inclined to the other plane - Straight lines inclined to both the planes - True length and inclination of lines with reference planes - Traces of lines.


b) Projections of polyhedra and solids of revolution - Frustums - Projections of solids with axis parallel to one plane and paralel to or perpendicular to the other plane - Projections of solids with the axis inclined to both the planes (Solids to be drawn - Cube, prism, pyramid, tetrahedron, cone and cylinder)

Module II (18 hours - 3 drawing exercises)a) Sections of solids - Sections by planes parallel to the horizontal or vertical planes and by planes inclined to the horizontal or vertical planes - True shape of section by projecting on auxiliary plane (Solids to be drawn: - Cube, prism, pyramid, tetrahedron, cone and cylinder)b) Development of surfaces of solids - Method of parallel line, radial line, triangulation and approximate developments - Development of polyhedra, cylinder, cone and sectional solids - Development of solids having hole or cut

Module III (18 hours - 3 drawing exercises) a) Introduction to isometric projection - Isometric scale - Isometric views - Isometric projections of prisms, pyramids, cylinders, cones, spheres, sectioned solids and their combinations - Principle of oblique projection - Cavalier, cabinet and general oblique projections of solids and simple objectsb) Introduction to multiview projection of objects - Principle of six orthographic views - Conversion of pictorial views of simple engineering objects into orthographic views

Module IV (22 hours - 6 drawing exercises)a) Introduction to machine drawing - Types of sectional views - Full-sectional and half-sectional views of simple machine componentsb) Conventional representation of threaded fasteners - Drawing of nuts, bolts, washers and screws - Locking arrangements of nuts - Bolted and screwed joints - Foundation bolts of eye end type, hook end type and split end type

Note: All drawing exercises mentioned above are for class work. Additional exercises wherever necessary may be given as home assignments

Reference books1. John K. C. & Varghese P. I, Engineering Graphics, Jet Publications2. Bhatt N. D, Elementary Engineering Drawing, Charotar Publishing House3. John K. C. & Varghese P. I, Machine Drawing, Jovast Publishers4. Bhatt N. D, Machine Drawing, Charotar Publishing House1.5. Narayana K. L & Kannaiah, P, Engineering Graphics, Tata McGraw Hill 6. Luzadder W. J, Fundamentals of Engineering Drawing, Prentice Hall of India

Sessional work assessmentDrawing exercises (Best 10) 10x3 = 302 tests 2x10 = 20Total marks = 50

University examination patternNo question from module 0Q I - 2 questions A and B of 20marks from module I with choice to answer any oneQ II - 2 questions A and B of 20marks from module II with choice to answer any oneQ III - 2 questions A and B of 20marks from module III with choice to answer any oneQ IV - 2 questions A and B of 40marks from module IV with choice to answer any one


EN2K 107A : ENGINEERING MECHANICS(A)(common for AI, CH, CE, CS, EE, EC, IT, IC, PT

2 hours lecture and 1 hour tutorial per week

ObjectivesTo build a strong foundation in Engineering Mechanics to serve as a basis for strength of materials, Mechanics of Solids and Structural AnalysisTo acquaint the student with general methods of analysing engineering problemsTo illustrate the application of the methods to solve practical engineering problems

Module I (17 hours)Principles of statics - Freebody diagrams - Composition and resolution of forces - Resultant and equilibrant- Concurrent forces - Triangle of forces - Lami’s therem - Method of projections - Method of moments-Theorem of varignon - Parallel forces - Couples - Centre of parallel forces and centre of gravity - Conditions of equilibrium for general system of coplanar forces - Polygon of forces - Resultant of a system of coplanar forces - Friction - Laws of friction - Angle of friction - Equilibrium of a body on a rough inclined plane

Module II (17 hours)Plane trusses - Different types of supports - Reactions at supports - Method of joints - Method of sections -Graphical method - Funicular polygon - Maxwell diagrams - Distributed forces in a plane - Flexible suspension cables - Introduction to vector approach - Concurrent and parallel forces in space - Couples in space - Equilibrium of general system of forces in space - Solution of problems by scalar and vector approach. Module III (16 hours)Principle of virtual work - Application to practical problems - Stable and unstable equilibrium - Simple machines - Centroids and moments of inertia of plane figures of various shapes-rectangle, triangle, circle, semicircle and builtup sections - Parallel and perpendicular axes theorems - Product of inertia - Principal axes and principal moments of inertia - Moment of inertia of a rigid body - Moment of inertia of a lamina -Moment of inertia of three dimensional bodies

Module IV (16 hours)Principles of dynamics - Differential equation of rectilinear motion - Motion of a particle acted upon by a constant force - Force as a function of time - Force proportional to displacement - Free vibrations- D’Alembert’s principle - Momentum and impulse - Work and energy - Ideal systems - Conservation of energy - Impact - Plastic, semielastic and elastic - Curvilinear motion - Differential equation - D’ Alembert’s principle - Work and energy - Moment of momentum - Projectiles - Rotation - Equation of motion - D’ Alembert’s principle - Rotation under the action of constant moment - Torsional vibration - Compound pendulum.

Text books1. Timeshenko & Young; Engineering Mechanics, McGraw Hill2. Shames I. H, Engineering Mechanics - Statics and Dynamics, Prentice Hall of IndiaReference books1. Beer F. P & Johnston E. R, Mechanics for Engineers - Statics and Dynamics, McGraw Hill2. Meriam J. L & Kraige L. G, Engineering Mechanics - Statics and Dynamics, John Wiley3. Langhaar H. L & Boresi A. P, Engineering Mechanics, McGraw Hill4. Rajasekaran & Sankarasubramanian, Engineering Mechanics, Vikas Publishing Company




EN2K 108 : COMPUTER PROGRAMMING IN C(common for all B. Tech. programmes)

2 hours lecture and 1 hour practical per week

Module I (11 hours)Programming and problem solving - Computer organisation - High level and low level languages - Steps involved in computer programming - Developing algorithms and flow charts - Efficiency of algorithms - Running - Debugging and testing of programs - Program design methods - Top-down modular programming - Measures of program performance

Module II (20 hours) Basics of C - Overview of C - Lexical elements - Operators and the C system - Fundamental data types - Flow of control - Functions Module III (20 hours)More on C - Arrays - Pointers and strings - Bit-wise operators and enumeration types - Structures and unions - Linear linked lists and list operations - Basic I/O functions

Module IV (15 hours)Introduction to object oriented programming - Principles of OOP - Object oriented programming paradigm - Basic concepts of OOP - Benefits of OOP - Object-oriented languages - Applications of OOP - Moving from C to C++ - Input /output functions - Classes and abstract data types - Overloading - Constructors and destructors - Inheritance - Polymorphism - Templates

Text bookKelley A & Pohl I, A Book on C, Addison WesleyReference books1. Schneider G. M, Weigngart S.W & Perlman D. M; An introduction to Programming and Problem

Solving with Pascal, John Wiley2. Balagurusamy E, Object Oriented Programming with C++", Tata McGraw Hill3. Venugopal K. R. & Prasad S. R, Programming with C, Tata McGraw Hill4. Gotfried B, Programming in C++, Schaum's Outline Series, McGraw Hill


University examination patternQ I - 8 short type questions of 5 marks, 2 from each module


Q II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15marks from module III with choice to answer any oneQ V - 2 questions A and B of 15marks from module IV with choice to answer any one

EC2K 109 : BASIC ELECTRICAL ENGINEERING(common with AI2K 109, EE2K 109, IC2K 109)


Module 1 (20 hours) Introductory circuit analysis - Two terminal resistance - Independent voltage and current sources -Dependent voltage and current sources - Ohm’s law - Kirchoff’s laws - Solution of simple series, parallel, series-parallel circuits with DC excitation - Solution of resistive circuits with dependent sources - Node analysis and mesh analysis - Nodal conductance matrix and mesh resistance matrix and effect of dependent sources on these matrices - Source transformation - Thevenin’s theorem and norton’s theorem - Magnetic circuits - MMF - Magnetic flux - Reluctance - Comparison of ferromagnetic material - Magnetisation curves of ferromagnetic materials - Energy stored in a magnetic field - Solution of magnetic circuits - Inductance - Faraday’s law of electromagnetic induction - Lenz’s law - Statically and dynamically induced e.m.f - Self and mutual inductance - Inductances in series and parallel - Mutual flux and leakage flux -Coefficient of coupling - Dot convention - Cumulative and differential connection of coupled coils - BH curve and inductance - Hysteresis loop - Capacitance - Electrostatics - Capacitance - Parallel plate capacitor - Capacitors in series and parallel - Charging and discharging of capacitor - Energy stored in electrostatic fields - Potential gradient - Dielectric strength

Module II (16 hours)Two terminal element relationships - v-i relationship for inductance and capacitance - Constant flux linkage theorem and constant charge theorem - v-i relationship for independent voltage and current sources - v-i relationship for dependent voltage and current sources - Source functions - Unit impulse - Unit step - Unit ramp and inter relationship - Sinusoidal input - Generalised exponential input - Linearity - Concept of a linear element - Concept of time invariance - Concept of a linear circuit - Superposition theorem - Substitution theorem - Passive vs active elements - Bilateral elements - Time domain analysis of circuits - Linear differential equations for series RC, parallel RC, series RL, parallel RL, series RLC, parallel RLC and coupled circuits - Complete solution for step/impulse/sinusoid voltage/current inputs - Natural response - Transient response - Time constant - Rise and fall times - Concept of d.c steady state and sinusoidal steady state - Frequency response of simple circuits from steady state solution - Solution of two mesh circuits by differential equation method - Determination of initial conditions

Module III (15 hours)Single phase a.c circuits - Alternating quantities - Generation of sinusoidal e.m.f - Average value - Effective value - Form and peak factors for square, triangle, trapezoidal and sinusoidal waveforms - Phasor representation of sinusoidal quantities - Phase difference - Addition and subtraction of sinusoids - Symbolic representation - Cartesian, polar and exponential forms - Analysis of a.c circuits R, RL, RC, RLC circuits using phasor concept - Concept of impedance, admittance, conductance and susceptance - Relation between s-domain immittance functions and phasor impedance/admittance - Power in single phase circuits - Instantaneous power - Average power - Active power - Reactive power - Apparent power - Power factor - Complex power - Solution of series, parallel and series-parallel a.c circuits - Application of Thevenin’s theorem and Norton’s theorem for a.c. circuits - Maximum power transfer theorem - Series and parallel RLC resonant circuits - Frequency response - Resonance - Q factor - Half power frequencies – Bandwidth


Module IV (15 hours)Analysis of polyphase circuits - Polyphase working - Two phase and three phase systems - 3 phase a.c systems - Balanced system - Phase sequence - Star delta transformation theorem - Balanced 3 phase a.c source supplying balanced 3 phase star connected and delta connected loads - Three phase loads with mutual coupling between phases - 3 wire and 4 wire systems - Neutral shift - Neutral current - Active power, reactive power, complex power, apparent power and power factor in balanced and unbalanced three phase systems - Measurement of power in balanced and unbalanced systems - Symmetrical components - Analysis of unbalanced systems using symmetrical components - Sequence impedances - Analysis of three phase unbalanced systems with mutual coupling between phases using symmetrical components - Sequence coupling

Reference books1. Kothari D. P & Nagarath I. J, Theory & Problems of Basic Electrical Engineering, Prentice Hall of India2. Hayt & Kimmerly; Engineering Circuit Analysis, McGraw Hill3. Siskind C. S, Electric Circuits, McGraw Hill4. Nilsson J. W & Riedel S. A, Electric Circuits, Addison Wesley5. Edminister J A, Electric Circuits, Schaum’s Series, McGraw Hill 6. Desoer C. A &Kuh E. S, Basic Circuit Theory, McGraw Hill



EC2K 110(P) : MECHANICAL WORKSHOP[common with AI2K 110(P), EE2K 110(P), IC2K 110(P)]

2 hours practicals per week

Module I (12 hours)Machine shop practice - Study of different machine tools - Lathe - Shaper - Milling machine - Drilling machine - Grinding machine - Exercises on lathe-models involving straight turning straight turning, taper turning, facing, knurling, boring and thread machining - Thread standards and specifications

Module II (12 hours)Fitting Practice - Study of hand tools and measuring tools used in fitting work - Fabrication exercises involving cutting, chiseling, filing and drilling - Use of thread dies and taps

Module III (10 hours)Welding Practice - Study of electric arc welding and gas welding equipment, accessories and tools - Safety practices - Exercises involving preparation of different types of welded joints - Lap and butt joints - Defects in welding - Testing of welded joints - Gas cutting equipment and demonstration

Module IV (10 hours)Sheet Metal practice - Study of shearing bending and folding machines, press brake etc. used in sheet metal work - Hand tools in sheet metal work - Development and fabrication of simple sheet metal components like


cylindrical dish, funnel, rectangular duct, tray, panel board etc, - Soldering and brazing of joints - Die cutting operations

Sessional work assessmentWorkshop practicals and record = 302 tests 2x10 = 20Total marks = 50

EC2K 111(P) : ELECTRICAL & ELECTRONICS WORKSHOP[common with AI2K 111(P), CS2K 111(P), IT2K 111(P), IC2K 111(P), PT2K 111(P)]

2 hours practicals per week for AI, EC, IC3 hours practicals per week for CS, IT, PT

Part A: Electrical Workshop (2/3 hours per alternate weeks)

1. Familiarisation of various types of Service mains - Wiring installations - Accessories and house-hold electrical appliances

2. Methods of earthing - Measurement of earth resistance - Testing of electrical installations - Precautions against and cure from electric shock

3. Practice of making Britannia joints on copper / aluminium bare conductors

4. Practice of making Married joints on copper / aluminium conductors

5. Practice of making T joints on copper / aluminium conductors

6. Wiring practice of a circuit to control 2 lamps by 2 SPST switches

7. Wiring practice of a circuit to control 1 lamp by 2 SPDT switches

8. Wiring practice of a circuit to control 1 fluorescent lamp and 1 three-pin plug socket

9. Wiring practice of a main switch board consisting of ICDP switch, DB, MCB's, and ELCB's

10. Familiarisation of various parts and assembling of electrical motors and Wiring practice of connecting a 3-phase / 1-phase motor with starter

Sessional work assessmentWorkshop practicals and record = 15Test/s = 10Total marks = 25

Part B – Electronics Workshop (2/3 hours per alternate weeks)

1. Familiarisation of various electronics components such as resistors, capacitors, transistors, diodes, IC’s and transformers

2. Assembling and soldering practice of single phase full wave bridge rectifiers circuit with capacitor filter

3. Assembling and soldering practice of common emitter amplifier circuit

4. Assembling and soldering practice of common emitter amplifier circuit on PCB

5. Assembling and soldering practice of non inverter amplifier circuit using OPAMP on PCB

6. Assembling of a timer circuit IC555, phase shift oscillator circuit using OPAMP and JK flip-flop using NAND gates on a bread-board

7. Coil winding - Single layer and multi layer - Demonstration


8. Miniature transformer winding - Demonstration

9. PCB fabrication - Demonstration

Sessional work assessmentWorkshop practicals and record = 15Test/s = 10Total marks = 25

3 RD SEMESTER

BT 301 ENGINEERING MATHEMATICS III(same as AI2K 301, CH2K 301, EC2K 301, EE2K 301, IC2K 301, ME2K 301, PE2K 301, PM2K 301)

3 hours lecture and 1-hour tutorial per week

Module I: Linear algebra IVector spaces - Subspaces - Linear dependence and independence - Bases and dimension - Linear transformations - Sums, products and inverses of linear transformations - Linear operator equations

Module II: Linear algebra IIRank and equivalence of matrices - Quadratic forms - Characteristic values and characteristic vectors of a matrix - Transformation of matrices - Functions of a square matrix

Module III: Probability distributions Random variables - Binomial distribution - Hypergeometric distribution - Poisson distribution - Mean and variance of probability distribution - Chebyshev's theorem - Poisson processes - Geometric distribution - Continuous random variables - Normal distribution - Uniform, log-normal, gamma, beta and Weibull distributions

Module IV: Statistical inference Populations and samples - Sampling distributions of mean and variance - Point estimation - Interval estimation - Bayesian estimation - Null hypotheses and significance tests - Hypothesis concerning one mean - Relation between tests and confidence intervals - Operating characteristic curves - Inferences concerning two means - Randomization and pairing - Estimation of variances - Hypotheses concerning one variance - Hypotheses concerning two variances - Test of goodness of fit

Text books1. Wylie C.R. & Barrett L.C., Advanced Engineering Mathematics, McGraw Hill (Chapters 13 & 14

excluding sections 14.1, 14.2 & 14.4 for modules I & II)2. Johnson R.A., Miller & Freund's Probability & Statistics for Engineers, Prentice Hall of India (Chapters

4, 5, 6, 7, 8 & section 9.6 excluding sections 4.9, 4.10, 5.10 & 5.13 for modules III & IV)Reference books1. Hadley G., Linear Algebra, Addison Wesley2. Kreyszig E., Advanced Engineering Mathematics, Wiley Eastern3. Kreider D.L., Kuller R.G., Osterberg & Perkins F.W., Introduction to Linear Analysis, Addison Wesley4. Levin R.I. & Rubin D.S., Statistics for Management, Prentice Hall of India5. Lipschutz S., Linear Algebra - Schaum's Outline Series, McGraw Hill6. Chatfield C., Statistics for Technology, Chapman & Hall7. Walpole R.E. & Meyers, Probability & Statistics for Engineers & Scientists, Prentice Hall of India



University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15 marks from module I with choice to answer any oneQ III - 2 questions A and B of 15 marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15 marks from module III with choice to answer any oneQ V - 2 questions A and B of 15 marks from module IV with choice to answer any one

BT 302 INSTRUMENTAL METHODS OF ANALYSIS


Module 1Absorption of radiation:

Absorptivity, Lambert Beers law, Deviations, Instrumentation, Double beam and single beam spectrometers, photometric – accuracy.

Spectrophotometer operation and instrumentation - optical materials sources, detectors spectrophotometers: Fourier transform spectrophotometers, calibration and standardization, atomization, flame atomization, background correction, detection limits, applications.

Module 2Scattering of radiation: Rayleigh scattering, instruments, analytical, applications molecular weights

and particle sizes, scattering in gases, turbidmetric and nephalometric titration.X-ray methods: The absorption of x-rays, monochromatic X-ray sources, X-ray detectors, x-ray

diffraction, and X-ray fluorescence.

Module 3Electrons and ion spectroscopy: X-ray photoelectron spectroscopy (XPS) ultraviolet photo electron

spectroscopy (UPS), electron impact spectroscopy, and auger electron spectroscopy, instrumentation radiation sources, energy analysis, detectors and auxiliary systems.

Module 4Thermometric methods, Thermo gravimetric analysis - thermo balance, derivative

thermowavimetric analysis - differential thermal analysis, DTA apparatus scanning calorimetric DTA.

References1. Willard and Merrit Instrumental Methods and Analysis, CBS Publishers & Distributors.2. Ewing GW, Instrumental Methods of Chemical Analysis, McGraw Hill Book Company.


University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any one


Q IV - 2 questions A and B of 15marks from module III with choice to answer any oneQ V - 2 questions A and B of 15marks from module IV with choice to answer any one


BT 303 CELL BIOLOGY


Module 1Cell as basic unit of living systems.

Eukaryotic and prokaryotic cells – Principles of membrane organisation – membrane proteins – cytoskeletal proteins – type of cell function Cell division:

Mitosis & meosis – extra cellular matrix

Cell cycle:

Cell cycle and molecules that control cell cycle

Cell culture:

Technique of propogation of prokaryotic and eukaryotic cells – contamination – differentiation

Module 2 Transport across cell mebranes

Passive and active transport – permeases, sodium-potassium pump – Ca2+-ATPase pumps – Lysosomal and vacular membrane ATP dependend proton pumps – Co-transport – symport – antiport – transport into prokaryotic cells – exocytosis and endocytosis – entry of viruses and toxins into cells

Module 3Receptors and models of extra cellular signalling

Cytosolic – nuclear and membrane bound receptors – examples of receptors – autocrine, paracrine and endocrine modes of action – quantification and characterisation of receptors

Module 4Signal transduction

Signal amplification – different models of signal amplification – cyclic AMP – role of inositol-phosphatase as messengers – biosynthesis of inositol tri-phosphates – cyclic GMP and G proteins – role in signal transduction – calcium ion flux and its role in cell signalling – current models of signal amplification – phosphorelation of protein kinases

References1.Darnell J, Lodish H, Baltimore D, Molecular Cell Biology, W.H .Freeman2.Kimball T.W. Cell Biology, Wesley Publishers 3.Charles Herbal Best and Noorman Burke Taylor, Living Body”,Chapman& Hall Ltd.


University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15marks from module III with choice to answer any one


Q V - 2 questions A and B of 15marks from module IV with choice to answer any one

BT 304 CHEMICAL ENGINEERING I


Module 1 Overview of process industry - unit operations and process conservation of mass and energy -SI units and conversion factors.

Module 2 Material balances

Overall and component material balances - Material balances. Without chemical reactions - Chemical reactions - stoichiometry - Conversion and yield - Material balance calculations with chemical reactions - combustion calculations - recycle operations.Energy balances

Entropy - Latent heat - Chemical reactions –combustion.

Module 3 Momentum transport:

Newton’s law of viscosity - Fluids - Types - Nature of flow - Momentum balance – Mechanical energy balance Macroscopic - differential balances - concepts

Pressure losses in flow systems - incompressible and compressible fluid flows

Module 4Dimensional analysis - Mixing and agitation - power consumption - scale up. Pumps and gas moving machinery – Pump characteristics -- Work of Consumption.

References1. Reynolds and Colburn, Momentum, Heat and Mass Transfer.2. W.L.McCabe & J.C.Smith , Unit Operations in Chemical Engineering, McGraw Hill 3. Foust CH .Durgaprasad & DVS Murthy,Process Calculation for Chemical Engineers.




BT 305 MICROBIOLOGY


Module 1Introduction – aims and scope, History of Microbiology, organization and function of prokaryotic and

eukaryotic cells; structure and function of prokaryotic cell organelles, cellular reserve materials, nucleus, effects of physical and chemical factors on microbial growth, control of microorganisms

Module 2 Distinguishing features of various groups of microorganisms, bacteria, molds, yeast and algae and their classification; characteristics of selected groups of microbes including archaebacteria and microorganisms of extreme environments

Module 3 Microbial growth

Different phases of growth, measurement of growth, uptake of nutrients, passive diffusion, facilitated diffusion, active trans port and group translocation, bacterial cell wall synthesis, bacterial respiration: anaerobic and aerobic

Module 4Microorganisms in soil, microorganisms in biogeochemical activity: carbon cycle, nitrogen cycle Microbes and industry, microbiology of air and wastewaterRole of microorganism in agriculture – nitrogen fixing microbes – phosphate solubility –

biopesticides Role of microorganism in public health, medicine – common diseases caused by microbes – TB,

leprosy, diahorrea, microbial production of antibiotics, vitamins.

Reference:1. Talaro K ,Talaro A Cassida Pelzar and Reid, Foundations in Microbiology, W.C.Brown Publishers.2. Pelzar M.J. Chan ECS and Krieg NR, Microbiology, Tata McGraw-Hill Edition, New Delhi.




BT 306 BIOCHEMISTRY


Module 1 Chemical bonds:

Ionic bond, covalent bond, co-ordinate covalent bond, metallic bonds, hydrogen bonds, hydrophilic interaction, Vander Vaal forces, ionization of water pH & pOH, Buffers, titration, pH meter and measurement of pH. Chemical reactions:

Chemical equations, oxidation-reduction reactions, oxidation number, molecular wt. calculations, solutions, solvent & solute, concentrations in solutions.

Module 2 Chemical composition of organic molecules, carbon as a unique bio-element.

Hydrocarbons : Alkenes, reactions of alkenes, polyenes, alkynes, reactions of alkynes, polymers.Alcohols: General formula, classifications, reactions, oxidation catalytic oxidation, replacement of

OH by halogens.Aldehyde & Ketones - Reactions of the carbonyl group, addition of HCN, reaction with NH 4CN,

Oxidation, peroxide oxidation

Module 3 Classes of biologically important compounds:

Carbohydydrates Classification, occurrence, structure and function of monosacharides, oligosaccharides and polysaccharides.

Amino Acids: Classification based on polarity, structure, amphoteric property of amino acids, peptide formation,

Proteins: Classification based on function, based on physical and chemical properties, structure, roles of the weak interaction in the stabilization of protein structure, Hydrolysis of proteins.

Lipids: Classification of lipids, fatty acids, fats, waxes, phospholipids, sphingolipide, glycolipids. Terpenes and steroids.

Module 4Secondary metabolites – classification and distribution, biological role of secondary metabolites. Enzymes: general account, co-enzymes and co-factors, classification and nomenclature of mechanism

of enzyme action.

Text Book1.Lehninger A.L.,Nelson D.L.,M.M cox, Principals of Biochemistry, CBS Publications,1993.2.Voet D,Voet G, Biochemistry, John Wiley and Sons.3.Stryer L ,Biochemistry.




BT 307 MICROBIOLOGY PRACTICAL

3 hours per week

1. Sterilization techniques (lecture & demonstration)) wet heat, dry heat, filtration, disinfection.2. Preparation of culture media ,cotton plugging and sterilization.3. Culturing of microorganisms: broth, agar, pure culture technique, streak plate, pour plate, Isolation

and preservation of bacterial culture.4. Identification of microorganisms: staining techniques, spore, capsule, fungal staining, biochemical

tests.5. Quantification of microorganisms: counting microscopy, nephalometry/ turbidometry ,total N or dry

weight.6. Environmental sample analysis, bacteriological analysis of water, SPC, presumptive test, confirmed

test, IMVic test7. Food microbiology: milk, fermented food.8. Cultivation of moulds and yeast.9. Growth curve of bacteria.10. Clinical Microbiology.


BT 308 BIOCHEMISTRY LAB

3 hours per week

1. Units, Volume/Weight measurements, concentrations units, pH. measurements. Preparation of buffers, Sensitivity, Specificity, precision and Accuracy. .

2. Qualitative tests for Carbohydrates. Estimation of. Reducing sugars by the Benedict's method.3. Qualitative tests for Amino Acids.4. Quantitative method for Amino Acids, Ninhydrin method .5. Protein estimation Biuret, Folin's, Spectrophotometry and Bradford Assay6. Acid hydrolysis of Proteins and Estimation of Amino acids by Ninhydrin, oPA, PTH.7. Extraction of lipids.8. Saponification of Fats.9. Phospholipids: Ashing and estimation of phosphate.10. Estimation of cholesterol11. Estimation of Nucleic Acids, Precipitation by sodium sulphate, Test for ribose and deoxyribose12. Enzyme assays: Phosphatase from potato, Amylase from sweet potato, Trypsin digestion of proteins



4 TH SEMESTER BT 401 ENGINEERING MATHEMATICS IV


Module I: Functions of a complex variable & applications I Functions of a complex variable - Analytic functions - Cauchy-Riemann equations - Elementary functions of z - Conformal mapping - Bilinear transformation - Schwarz-Christoffel transformation - Transformation by other functions

Module II: Functions of a complex variable & applications II Integration in the complex plane - Cauchy's integral theorem - Cauchy's integral formula - Series of complex terms - Taylor's series - Laurent's series - Residue theorem - Evaluation of real definite integrals - Complex inverse integral

Module III: Ordinary differential equations & special functions Power series method of solving ordinary differential equations - Theoretical preliminaries - Series solution of Bessel's equation - Modified Bessel functions - Equations solvable in terms of Bessel functions - Identities for Bessel functions - Orthogonality of Bessel functions - Applications - Legendre polynomials

Module IV: Partial differential equations Derivation of equations - D'Alembert's solution of the wave equation - Characteristic and the classification of partial differential equations - Separation of variables - Orthogonal functions and the general expansion problem - Further applications - Laplace transform methods

Text bookWylie C.R. & Barrett L.C., Advanced Engineering Mathematics, McGraw Hill (Chapters 11,12,17,18,19 & 20 excluding Section 11.9)Reference books1. Churchill R.V., Brown J.W.& Verhey R.F., Complex Variables & Applications, McGraw Hill2. Kreider D.L., Kuller R.G., Ostberg D.R & Perkins F.W., An Introduction to Linear System Analysis,

Addison Wesley3. Kreyszig E., Advanced Engineering Mathematics, John Wiley4. Pipes L.A & Harvill L.R., Applied Mathematics for Engineers & Physicists, McGraw Hill5. Sokolnikoff I.S. & Redheffer R.M, Mathematics of Physics & Modern Engineering, McGraw Hill


University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15 marks from module I with choice to answer any oneQ III - 2 questions A and B of 15 marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15 marks from module III with choice to answer any oneQ V - 2 questions A and B of 15 marks from module IV with choice to answer any one


BT 402 CHEMICAL ENGINEERING II


Module 1Heat transport:

Mechanism of Heat Transfer – thermal conductivity, Fourier’s law Conduction

Heat Conduction - Dimensional Analysis - Conduction through series resistances - Two-dimensional conduction

RadiationAbsorptivity, Reflectivity, transmissivity – black and grey body – laws of radiation

Module 2 Convection

Film concept- individual and overall heat transfer coefficient- Forced Convection

Forced Convection in tubes and other geometries – Combined conduction - extended surfaces - shape factors.Natural convection

Mechanism – dimensional analysisBoiling and condensation - Heat transfer to Non-Newtonian Fluids.

Module 3 Heat Exchanger

Design of heat exchangers - Evaporators - Overall heat transfer coefficients - Calculation for single and multiple effects. Drying

Air Properties - Drying Equipments - Drying rates and drying time - Drying & Thermal Processing of biological materials.

Module 4 Particle Size

Particle size distribution – Methods of size analysisMechanical separations Filtration

Constant pressure and constant rate filtration - Industrial Filters - Design - Centrifugal separation Settling and sedimentation

Text Book1. W.L.McCabe & J.C.Smith , Unit Operations in Chemical Engineering, McGraw Hill 2. Christe J.Geankopies, Transport Process and Unit Operations, Prentice Hall India Pvt.Ltd.

References1. Robert E Traybal, Mass Transfer Operations McGraw-Hill International editions.


University examination patternQ I - 8 short type questions of 5 marks, 2 from each module


Q II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15marks from module III with choice to answer any oneQ V - 2 questions A and B of 15marks from module IV with choice to answer any one

BT 403 BIOCHEMISTRY II


Module 1Introduction to biomolecules

Structure and properties of Mono, Di Oligo and polysaccharides, complex carbohydrates, Structure and properties of Fatty acids, Glycerolipids, phospholipids, sphingolilpids, glycolipids, steroids, Structure and properties of amino acids, Peptides, proteins and conjugated proteins. Structure and properties of purines, pyrimidines; nucleosides, nucleotides, polynucleotides, Ribonucleic acids, and deoxy ribonucleic acids, nucleoprotein complexes.

Module 2Metabolic pathways:

TCA cycle, glycolysis, gluconeogenesis, Pentose phosphate shunt, Embden Meyerhof pathway, urea cycle, interconnection of pathways

Module 3Metabolism: Biosyntheses and degradation of fatty acids and cholesterol biosyntheses and degradation of amino acids, peptides and proteins; Biosynthesis and degradation of amino acids, peptides and proteins, Biosyntheses and degradation of Purines, pyrimidines and nucleic acids

Module 4Metabolic regulation and Bioenergetics:

Respiratory chain, TCA cycle, energy rich compounds – Entropy Free energy concept. Energy of activation - standard free energy changes in chemical reactions. Energy production in biological reaction. High energy and low energy phosphate compounds. Free energy of hydrolysis of ATP.

References

1. Zubay G, Biochemistry, Maxwell Macmillan International Editions.

2. Stryer L, Biochemistry.




BT 404 MOLECULAR BIOLOGY


Module 1DNA

Structure of DNA - different forms of DNA and RNA - Secondary structure in single stranded nucleic acids.

GeneThe concept of gene – gene structure – genetic code

Module 2Replication

Experiments of Meselson and StahlMechanism of Replication – rolling circle model - concurrent/simultaneous DNA replication-

enzymes and proteins involved in replication - regulation – differences in DNA and RNA synthesis

Module 3

Gene expression in prokaryotes:

Transcription - Translation, codon usage, inhibitors of transcription and translation.

Gene expression in eukaryotes:

Exon - intron concepts, transcription initiation factors and characteristics motifs in these factors, promoters and enhancers

Module 4Mutation - Gene regulation - operon concept gal, lac, trp – Eukaryotes : Organization

of genome - interaction with histones. RNA splicing - Retroviruses, retroposons and oncogenes.

References

1. Freifelder D. Molecular Biology, Jones and Bartlett Publishers Inc.

2. Benjamin Lewin, Genes VI, Oxford University Press, Oxford ,New York




BT 405 BIOPROCESS PRINCIPLES


Module 1Introduction to bioprocesses:

Historical development of bioprocess technology, an overview of traditional and modern applications of biotechnological processes, role of bioprocess engineer in the biotechnology industry, outline of an integrated bioprocess and the various (upstream and downstream) unit operations involved in bioprocesses, generalized process flow sheets

Module 2Fermentation processes:

General requirements of fermentation processes, Basic design and construction of fermentor and ancillaries, Main parameters to be monitored and controlled in fermentation processes, An overview of aerobic and anaerobic fermentation processes and their application in the biotechnology industry, solid-substrate fermentation and its applications

Module 3Metabolic stoichiometry and energetics:

Stoichiometry of Cell growth and product formation, elemental balances, degrees of reduction of substrate and biomass, available, electron balances, yield coefficients of biomass and product formation, maintenance coefficients Energetic analysis of microbial growth and product formation, oxygen consumption and heat evolution in aerobic cultures, thermodynamic efficiency of growth.

Enzymatic bioconversion processes: Kinetics and thermodynamics of enzyme-catalyzed reactions. Techniques of enzyme

immobilization, basic design and configuration of immobilized enzyme reactors, applications of immobilized enzyme technology.

Module 4

Media design and sterilization for fermentation processesMedium requirements for fermentation processes, carbon, nitrogen, minerals, vitamins and other complex nutrients, oxygen requirements, medium formulation for optimal growth and product formation, examples of simple and complex media, design and usage of various commercial media for industrial fermentations, thermal death kinetics of micro organisms,- batch and continuous heat, sterilization of liquid media, filter sterilization of liquid media, Air, Design of sterilization equipment.

References

1. Bailey and Ollis, Biochemical Engineering Fundamentals, McGraw Hill

Shule and Kargi, Bioprocess Engineering ,Prentice Hall.




BT 406 GENETICS


Module 1Classical geneticsMendelian laws of inheritance – monohybrid and dihybrid inheritanceThe genetic material

Identification of the genetic material - classical experiments, Hershey Chase, Avery McLeod etc

Nature of genetics material - nucleic acids - DNA replication

Module 2Chromosomes:

Chemical composition, structural organization of chromatids, centromeres, telomeres, chromatin, nucleosome organization, eu-and heterochromatin, special chromosomes (eg., polytene and lampbrush chromosomes), Banding patterns in human chromosomes.

Multiple alleles and blood group antigens Sex chromosomes and sex linked inherited disorders

Module 3Genetic mapping

Linkage, mapping genes, interference, coincidence in prokaryotes and eukaryotesModern genetics

Gene interactions - sex determination in plants and animals’ - sex linkage, nondisjunction (as a proof of chromosomal theory of inheritance)

Structural and numerical aberrations involving chromosomes, hereditary defects –Kleinfelter, turner, cri-du-chat and down syndromes.

Module 4Mutations:

Spontaneous and induced, chemical and physical mutagens, induced mutation.Genetic transfer:

Conjugation, Transduction and Transformation.

References

1. Gardener EJ, Simmons MJ, Slustad DP, Principals of Genetics.

2. Goodenough U, Genetics, Hold Saunders International.




BT 407 MOLECULAR BIOLOGY LAB

3 hours per week

1. DNA isolation from suitable materials.2. Biochemical estimations:DNA estimation(colourimetry method),RNA,proteien3. Bacterial titration & Viable counting.4. Conjugation in E.coli5. Transformation in E.coli6. Phage infection in E.coli7. Induction of Lac operon.8. Complementation experiments.


BT 408 CHEMICAL ENGINEERING LABORATORY I

3 hours per week

1. Calibration of orifice meter and rotameter2. Flow trough straight pipe, annular pipe, packed bed 3. Fluidization4. Jaw crusher, crushing tools5. Size analysis.6. Leaf filters, filter press, rotary drum filters7. Heat loss in pipes8. Heat exchanges9. Film type evaporator.



5 TH SEMESTER

BT 501 : SOFTWARE ENGINEERING (common for all programmes)


Module I Introduction - FAQs about software engineering - professional and ethical responsibility - system modeling - system engineering process - the software process - life cycle models - iteration - specification - design and implementation - validation - evolution - automated process support - software requirements - functional and non-functional requirements - user requirements - system requirements - SRS - requirements engineering processes - feasibility studies - elicitation and analysis - validation - management - system models - context models - behavior models - data models - object models - CASE workbenches

Module II Software prototyping - prototyping in the software process - rapid prototyping techniques - formal specification - formal specification in the software process - interface specification - behavior specification - architectural design - system structuring - control models - modular decomposition - domain-specific architectures - distributed systems architecture - object-oriented design - objects and classes - an object oriented design process case study - design evolution - real-time software design - system design - real time executives - design with reuse - component-based development - application families - design patterns - user interface design - design principles - user interaction - information presentation - user support - interface evaluation

Module III Dependability - critical systems - availability and reliability - safety - security - critical systems specifications - critical system development - verification and validation - planning - software inspection - automated static analysis - clean room software development - software testing - defect testing - integration testing - object-oriented testing - testing workbenches - critical system validation - software evolution - legacy systems - software change - software maintenance - architectural evolution - software re-engineering - data re-engineering

Module IV (13 hours)Software project management - project planning - scheduling - risk management - managing people - group working - choosing and keeping people - the people capability maturity model - software cost estimation - productivity estimation techniques - algorithmic cost modeling, project duration and staffing quality management - quality assurance and standards - quality planning - quality control - software measurement and metrics - process improvement - process and product quality - process analysis and modeling - process measurement - process CMM - configuration management - planning - change management - version and release management - system building - CASE tools for configuration managementText book1. Ian Sommerville, Software Engineering, Pearson Education AsiaReference books1. Pressman R. S., Software Engineering, McGraw Hill2. Mall R., Fundamentals of Software Engineering, Prentice Hall of India3. Behferooz A. & Hudson F.J., Software Engineering Fundamentals, Oxford University Press4. Jalote P., An Integrated Approach to Software Engineering, NarosaSessional work assessmentAssignments 2x10 = 202 tests 2x15 = 30


Total marks = 50


BT 502 INDUSTRIAL BIOTECHNOLOGY


Module 1Introduction to industrial bioprocess:

A historical overview of Industrial fermentation processes and products - Role of a bioprocess engineer in the Biotechnology Industry - Outline of the various unit operations involved in an integrated bioprocess - Process Flow-Sheeting - a brief survey of organisms, processes, products and market economics relating to modern industrial biotechnology.Raw materials for fermentation process:

Isolation, Preservation and Improvement of Industrial Microorganisms for overproduction of Primary and Secondary metabolites - Medium requirements for fermentation process: carbon, nitrogen, minerals, vitamins and other nutrients - examples of simple and complex media.

Module 2Production of primary metabolites:

A brief outline of processes for the production of some commercially important organic acids (e.g. citric acid, lactic acid, acetic acid, gluconic acid, etc) - Amino acids (glutamic acid, lysine, aspartic acid, phenylalanine etc) - Alcohols (ethanol, 2,3butanediol etc.)

Module 3Production of secondary metabolites:

Study of production processes for various classes of low molecular weight secondary metabolites – Antibiotics – beta-lactams (Penicillins, Cephalosporins etc.), amino glycosides (streptomycin,kanamycin etc.), macrolides (erythromycin), quinones, aromatics etc. - Vitamins and Steroids.Production of commercially important enzymes: Proteases, Amylases, Lipases, Cellulases, Pectinases, Isomerases and other commercially important enzymes for the food and pharmaceutical industries

Module 4Production of recombinant proteins

Proteins having therapeutic and diagnostic applications - production of vaccines.Specialty bioproducts

Bioproducts for agricultural food and pharmaceutical industries - Biopesticides, Biofertilizers and Plant Growth Factors - Natural Bio-preservatives (Nisin), Biopolymers ( Xanthan Gum and PHB) - Single Cell Proteins.Enzymatic bioconversion processes:

Production of synthetic Penicillins and Cephalosporins - Racemically-pure Drug Intermediates - Steroid Bioconversions - High -Fructose Corn syrup - Bioconversion of Vegetable Oils.

References1. Moorray-Mu-Young. Comprehensive Biotechnology, Pergamon Press.2. Prescott and Dunn, Industrial Microbiology, C.B.S.Publishers & Distributors.


3. Cascida, L.E., Industrial Microbiology, New Age InternationalSessional work assessmentAssignments 2x10 = 202 tests 2x15 = 30Total marks = 50


BT 503 CHEMICAL REACTION ENGINEERING


Module 1Basics of kinetics: Introduction, Kinetics of Homogeneous reactions - searching for mechanism -

Arrhenius equation - Batch reactor analysis (integral and differential methods) for kinetics.Multiple reactions - parallel, series and series-parallel

Module 2Reactor Design: Introduction to reactor designIdeal reactors - Single reactor and multiple reactor design - Design Principles

Module 3Non Isothermal reactors and pressure effectsNon-ideal flow - Non-ideal flow models and reactor performance.

Module 4Biochemical Reactions - Cell growth - Rate equations Stoichiometry - Mass balance - Design

Equations.

References1. Octave Levenspiel-Chemical Reaction Engineering, John Wiley2. H.Scott Fogler, Elements of Chemical Reaction Engineering, Prentice Hall India Pvt.Ltd.




BT 504 GENETIC ENGINEERING


Module 1Role of genes within cells - elucidation of the genetic code - genetic elements that control gene

expression - method of creating recombinant DNA molecules

Module 2Basic tools of genetic engineering: Restriction endonucleases, ligases, modifying enzymes -

Restriction enzymes and mapping of DNA.Cloning vectors: salient features of vectors, plasmid and phage vectors – vector design

Module 3Construction of recombinant DNA by various methods - Generation of DNA fragments by

restriction endonuclease digestion - Joining of DNA molecules - homopolymer tailing - ligation of cohesive and blunt ended terminal - linkers and adapters

Module 4c-DNA synthesis -Construction of genomic and cDNA libraries - methods of nucleic acid

sequencing, expression of cloned genes Application of recombinant DNA technology: Cloning in plants, Ti plasmid of agrobacteria,

transgenic animals.

References1. Old RW,Primrose SB, Principals of Gene manipulation, An Introduction to Genetic

engineering,Black well Scientific Publications.2. Sambrook,J.,Fritsch,E.F. and Maniatis, T. Molecular cloning –a Laboratory Manual. Cold Spring

Harbor laboratory Press.




BT 505 MASS TRANSFER AND SEPARATION


Module 1Diffusion in gases, liquids and solids - Convective mass transfer and mass transfer coefficients –

interphase mass transfer Vapour - liquid equilibrium

Absorption and stripping - Simple, steam and flash Distillation - Distillation with reflux - McCabe Thiele method and enthalpy - concentration method.

Module 2Liquid-Liquid equilibrium

Triangular coordinate system - Staged and Continuous extraction Solid -liquid extraction

Equilibrium relation and staged leaching

Module 3Drying

Characteristics of materials - Theory and mechanism of drying - Estimation of drying rates Different types of dryers - Design and performance of continuous and batch dryers.

Module 4Adsorption

Equilibrium - Batch and fixed bed Adsorption -Ion exchange process.Membrane separation processes - Types liquid and gas membrane processes - Complete mixing, cross flow and Counter current flow modals.

References1. Robert E.Treybal ,Mass Transfer Operations,McGraw Hill International Editions.2. Christi J.Geankoplis, Transport Process and Unit Operations, Prentice Hall India Pvt.Ltd.




BT 506 ENZYME ENGINEERING & TECHNOLOGY


Module 1Applications of enzymes:

Classification of Enzymes; Commercial applications of enzymes in food, pharmaceutical and other industries; Enzymes for analytical and diagnostic applications.

Purification and characterization of enzymes from natural sources: Production and Purification of Crude Enzyme extracts from plant, animal and microbial sources -

some case studies - methods of characterization of enzymes - development of enzymatic assays.

Module 2Mechanisms and kinetics of enzyme action:

Mechanisms of Enzyme Action - Concept of active site and energetics of enzyme substrate complex formation - Specificity of enzyme action - Kinetics of single substrate reactions - turnover number - estimation of Michaelis-Menten parameters

Multisubstrate reactions - mechanisms and kinetics - Types of Inhibition kinetic models - Substrate and Product Inhibition - Allosteric regulation of enzymes - Deactivation kinetics.

Module 3Enzyme immobilization

Physical and Chemica1 techniques for enzyme immobilization adsorption, matrix entrapment, encapsulation, cross-linking, covalent binding etc.,-examples - advantages and disadvantages of different immobilization techniques - overview of applications of immobilized enzyme systems.

Mass transfer effects in immobilized enzyme systems: Analysis of Film and Pore Diffusion Effects on Kinetics of Immobilized Enzyme Reactions - Formulation of dimensionless groups and calculation of Effectiveness Factors.

Module 4Design of enzyme reactors for bioconversion processes:

Design of Immobilized Enzyme "Reactors-Packed-bed, Fluidized bed and Membrane reactors - Bioconversion calculations in free enzyme CSTRs and immobilized enzyme reactors.

Enzyme biosensors: Applications of enzymes in analysis; Design of enzyme electrodes and their application as biosensors in industry, health care and environment.

References

1. Zubay G, Biochemistry, Maxwell Macmillan International Editions.

2. Gerharts,W, Enzymes in Industry-Production and Application.

3. Tailer,R.F, Protein Immoblisation-fundamentals and applications.


University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any one


Q IV - 2 questions A and B of 15marks from module III with choice to answer any oneQ V - 2 questions A and B of 15marks from module IV with choice to answer any one

BT 507 CHEMICAL ENGINEERING LABORATORY II

3 hours per week

1. Heater – determination of heat transfer efficiency2. Heat transfer from steam to air – Determination of overall heat transfer coefficient3. Determination of overall heat transfer coefficient by radiation to water flowing through pipe4. Study of long tube evaporator5. Verification of material balance equation and Rayleigh’s equation for simple distillation6. Vaporization efficiency in steam distillation7. Drying – rate of drying curve under constant drying condition8. Leaching – Principles of leaching from leaching a mixture of salt and sand9. Ternary liquid equilibrium10. Adsorption isotherms11. Kinetics of chemical reaction in batch reactors, tubular flow and stirred tank reactors12. Open loop response of a two link liquid level system13. Frequency response of first and second order


BT 508 INSTRUMENTAL METHODES OF ANALYSIS LAB

3 hours per week

1. Precision and validity of an experiment2. Lambert-Beers law using UV-Vis Spectrometer3. Emission spectra of anthracene using spectroflouimeter4. IR of hydrocarbons using IR spectrometer5. Principles of TCA and DSC6. Operation of NMR and EPR spectrometer.



6 TH SEMESTER

BT 601 BIOETHICS & IPR


Module 1The legal and socioeconomic impacts of biotechnology - Public education of the processes of biotechnology involved in generating new forms of life for informed decision making - Biosafety regulation and national and international guidelines - rDNA guidelines

Module 2Experimental protocol approvals - levels of containment - Environmental aspects of biotech applications - Use of genetically modified organisms and their resistance in environment - Special procedures for r-DNA based product production

Module 3Intellectual property rights - TRIP International conventions patents and methods of application of patents - Legal implications - Biodiversity and farmers rights - Beneficial applications’ and development of research focus to the need of the poor - Identification of directions for yield effect in agriculture, aquaculture Bioremediation etc.

Module 4Objectives of the patent system - basic principles and general requirements of patent law - biotechnological inventions and patent law - legal development - patentable subjects and protection in biotechnology - The patentability of microorganisms - IPR and WTO regime - consumer protection and IPR - IPR and plant genetic resources - GATT and TRIPS.

References1. Beier,F.K.,Crespi,R.S. and Straus,J. Biotechnology and Patent protection-Oxford and IBH

Publishing Co.New Delhi.2. Sasson A, Biotechnologies and Development, UNESCO Publications.3. Singh K, Intellectual Property rights on Biotechnology, BCIL,NewDelhi.




BT 602 BIOINFORMATICS


Module 1What is bioinformatics - Scope of bioinformatics - Elementary commands and Protocols – FTP –

Telnet – HTTP - Primer on information theory. Sequencing alignment and dynamic programming - Introduction - Strings - Edit distance between two strings - string similarity - local alignment - gaps - parametric sequence alignments - subtropical alignments - multiple alignment - common multiple alignment methods.

Module 2Sequence databases and their use - Introduction to databases - database search - Algorithms issues in

databases - search sequence database search - FASTA - BLAST - Amino acid substitution matrices PAM and BLOSSUM.

Module 3Evolutionary trees and phylogeny

Phylogenetic trees - parsimony -Ultra metric problem perfect phylogeny - Phylogenetic alignment - connection between multiple alignment and tree construction

Module 4Special topics in bioinformatics

DNA Mapping -and sequencing - Map alignment - Large scale sequencing and alignment - Shotgun - DNA sequencing - Sequence assembly - Gene predictions - Molecular predictions with DNA strings - Neural network and cybernetics - genetic algorithms.

References1. P.Baldi,S.Brunk, Bioinformatics, A Machine Learning Approach. MIT Press.2. Dan Gusfield, Algorithms on Strings Trees and Sequences, Cambridge University Press.




BT 603 BIOPROCESS ENGINEERING


Module 1Design and analysis of bioreactors:

Modelling of Non-Ideal Behavior in Bioreactors - Tanks-in-series and Dispersion models - applications to design of continuous sterilisers - Design and operation of novel bioreactors - Air-lift loop reactors - Fluidized-bed bioreactors - Stability analysis of bioreactors.

Module 2Bioreactor scale-up:

Regime analysis of bioreactor processes - Correlations for oxygen transfer - Scale-up criteria for bioreactors based on oxygen transfer and power consumption.Monitoring of bioprocesses:

On-line data analysis for measurement of important physicochemical and biochemica1 parameters - Methods of on-line and off-line biomass estimation - microbial calorimetry - Flow injection analysis for measurement of starters, products and other metabolites - State and parameter estimation techniques for biochemical processes - Computer-based data acquisition, monitoring and control - Labview Software.

Module 3Modern biotechnological processes

Recombinant cell culture processes - guidelines for choosing host vector systems -plasmid stability in recombinant cell culture - limits to over expressionn - Modelling of recombinant bacterial cultures - Bioreactor strategies for maximising product formation -Bioprocess design considerations for plant and animal cell cultures.

Module 4Modelling and simulation of bioprocesses

Study of Structured Models for analysis of various bioprocess - Model simulation using MATLAB-SIMULINK and ISIM software packages.

References1. Shule and Kargi, Bioprocess Engineering, Prentice Hall2. Baiely and Ollis, Biochemical Engineering Fundamentals., Mc Graw Hill.3. Stanbury,P.F. and Whitaker A, Principles of Fermentation Technology, Pergamon Press.




BT 604 IMMUNOLOGY & IMMUNOTECHNOLOGY


Module 1The immune system:

Introduction – lymphocytes - their origin and differentiation – antigens - their structure and classification - complement and their biological functions.

Types of immune responses - anatomy of immune response

Module 2Humoral immunity:

B-Iymphocytes and, their activation - structure and function of immunoglobulin - Immunoglobulin classes and subclasses - genetic control of antibody production - mono clonal antibodies and diagnosis - idiotypes and idiotypic antibodies - major histocompatibility complex.Cellular immunology:

Thymus derived lymphocytes (T cells) their classification antigen presenting cells (APC) - macrophages,langerhanscells - their origin and functions - mechanisms of phagocytosis - identification of cell types of immune system – immunosuppression - immune tolerance

Module 3Immunity to infection:

Hypersensitivity reactions - mechanisms of T cell activation - cytokines and their role in immune response macrophage activation and granuloma formationTransplantation:

Graft rejection - evidence and mechanisms of graft rejection - prevention of graft rejection - immunosuppressive drugs - HLA and disease - mechanisms of immunity to tumor antigensAutoimmunity:

Autoantibodies in humans - pathogenic mechanisms - experimental models of autoimmune disease treatment of autoimmune disorders.

Module 4Molecular immunology:

Preparation of vaccines - application of recombinant DNA technology for the study of the immune system - production of antiidiotypic antibodies - catalytic antibodies - application of PCR technology to produce antibodies and other immonological reagents - immunotherapy with genetically engineered antibodies.Current topics in Immunology.

Hybridoma techniques and monoclonal antibody production – Diagnostic methods : Immunodiffusion, Immunoelectrophoresis, Radioimmunoassay, ELISA, Western blot, Epitope mapping -Trends in Immunology of infectious diseases and tumours.

References1. Janis Kuby, Immunology, W.H. Freeman & Company2. Roitt, I..M., Brostoff.J., and Male. D.K., Immunology, Mosby Publication.3. Ivan l., Immunological Methods Manual, Accademic Press.




BT 605 ENVIRONMENTAL BIOTECHNOLOGY


Module 1Components of environment and assessment of its quality - Factors of environmental degradation

and pollution - pollutants and their types - nature and source.Microbial biodiversity - strategies for accessing – bioprospecting - recovery by the use of

environmental DNA - Extremophiles and their application.

Module 2Environmental genomics - Deliberate release of recombinant microorganisms - biomarkers and

bioreceptors Bioremediation – bioremediation of petroleum based wastes – phytoremediation – bioleaching -

degradation of pesticides, herbicides, polyaromatic hydrocarbons – xenobiotics - metabolic engineering

Module 3Waste treatment – Waste disposal and mangement - Microbiological and biochemical aspects of

waste treatment processes - Microbial strain improvement with a view to develop scavengers - Characterisitcs of waste water - Aerobic and anerobic waste teratment process (with examples) industrial waste - agricultural waste - municipal waste - Biological treatment of solid wastes.

Module 4Downstream processing in biological waste treatment process - effluent disposal and reuse -

Biofilteration for waste gas treatment - purification of biogas - contaminant of biologically toxic wastes - economy of biological treatment process.

References1. Mooray –Mu- Young, Comprehensive Biotechnology, Premagaon Press.2. Raina M. Mayer., Environmental Microbiology, ASM Press.3. Foster,C.F.,John Ware D.A. Environmental Biotechnology, Ellis Horwood Ltd.




BT606(A) BIOMEDICAL ENGINEERING


Module 1Muscle structure and its attachment with skeleton - rate of contraction and force generation -

Activation contraction – locomotion-stability - forces on ground - forces on muscles - energy requirement - mechanisms of walling, running and trotting - sports

Module 2Biomechanics –

mechanical analysis of performance - rehabilitation biomechanics - mechanics of prosthetics and orthotics - biomechanic of human injury and orthopaedics fixation - mechanics of bones and joint - dynamics of man machine interaction.

Module 3Electrical impedance cephalography – biotelemetry - biosignal analyser - biosystem modelling.

Module 4 Ultrasound in diagonosis - limb prosthetics and orthotics - sensory aids for the blinds - assisting the

heart and kidney – ECG – EEB - Physiological equipments.

References1. Atilla Hincal A., Suheylakas,H., Biomedical Science & Technology, Plenum Press NewYork




BT606(B) CANCER BIOLOGY


Module 1Fundamentals of cancer biology:

Regulation of Cell cycle - mutations that cause changes in signal molecules - effects on receptor - signal switches - tumour suppressor genes - modulation of cell cycle-in cancer - Different forms of cancers - Diet and cancer.

Module 2Principles of carcinogenesis:

Chemical Carcinogenesis - Metabolism of Carcinogenesis - Natural History of Carcinogenesis - Targets of Chemical Carcinogenesis - Principles of Physical Carcinogenesis - X-ray radiation mechanism of radiation carcinogenesis.

Module 3Principles of molecular cell biology of cancer:

Oncogenes - Identification of Oncogenes - Retroviruses and Oncogenes - detection of Oncogenes Growth Factor and Growth Factor receptors that are Oncogenes - Proto Oncogene activity - Growth factors related to transformations.

Module 4Principles of cancer metastasis

Clinical significances of invasion -heterogeneity of metastatic phenotype - Metastatic cascade -

Basement Membrane disruption - Three step theory of Invasion - Proteinases and tumour cell invasion - New

molecules for cancer therapy.Different forms of therapy – Chemotherapy - Radiation Therapy - Detection of Cancers - Prediction

of aggressiveness of Cancer - Advances in Cancer detection.

References1. An Introduction to Cellular and Molecular Biology of Cancer, Oxford Medical Publications.




BT606(C) BIOPHARMACECUTICAL TECHNOLOGY


Module 1Introduction:

Development of Drug and Pharmaceutical Industry - Therapeutic agents - their uses and economics - Regulatory aspects.

Basic concepts of developmental Biology - mosaic and regulative development - pattern formation - positional information.

Module 2Drug metabolism-

Drug metabolism and pharmacokinetics - physico chemical principles - radioactivity pharma kinetics - action of drugs on human bodies.

Bulk drug Manufacturing - Types of Reactions in Bulk drug Manufacture and Processes - Special Requirements for Bulk Drug Manufacture.

Module 3Important unit processes and their applications

Compressed tables - wet granulation - dry granulation or slugging - direct compression - tablet presses - coating of tablets - capsules sustained action dosage forms - parental solutions – oral liquids – injections – ointments - Topical Applications

Preservation - analytical methods and test for various drugs and pharmaceuticals Packing - Packing Techniques - Quality Management, GMP

Module 4Pharmaceutical products and their controlTherapeutic - catgories such as vitamins – laxatives – analgesics - nonsteroidal contraceptives –

Antibiotics – biologicals - hormones.

References1. Leon Lachman etal, Theory and Practice of Industrial Pharmacy, Lea and Febiger.




BT606(D) ANIMAL BIOTECHNOLOGY


Module 1Introduction:

What is Animal Biotechnology and its scope - animals in Biotechnology - State of the Art.

Module 2Animal cell culture:

Principles of sterile techniques and cell propagation - Chemically defined and serum Free media for membrane cell culture - scaling up of animal cell cultures - preservation and characterisation of animal cells - organ culture - cytotoxity and viability assays - Cell cultures as sources of valuable products.

Module 3Genetic recombination techniques:

Mammalian genome, genetic recombination in mammalian cells and embryos Cloned animals

Module 4Protein production by genetically engineered mammalian cell lines - optimisation of animal cells

growth in bio reactors - Emission.

References1. Bernur,R,Pastrnek,J.J, Molecular Biology ,Principles and Applications in Recombinant DNA,

Panima Publishing Cooperation, New Delhi.




BT 607 BIOPROCESS LAB

3 hours per week

1. Isolation of microbes for the production of antibiotics; Antibiotic sensivity test against common microbes

2. Enzyme isolation and assay3. Enzyme kinetics4. Enzyme immobilization.5. Production of secondary metabolites and assay.6. Estimation of Michaelis Menton parameters,effect of pH and temperature on enzyme activity,

kinetics of inhibition.7. Estimation of biomass8. Growth of micro-organisms and estimation of Monod parameters.9. Production of citric acid and alcohol and their estimation.


BT 608 IMMUNOLOGY LAB

3 hours per week

1. Histology of lymphoid organs.2. Blood grouping3. Preparation of antigens-protocol of immunization in rabbits, methods of bleeding, purification and

production of polyclonal antibodies.4. Separation of lymphocytes from blood5. Antigen –antibody reactions-Haemagglutination, Immunodiffusion, Immunoelectrophorosis6. Affinity chromatography for Ab purification7. Flurochrome-Ab conjugation-Biotin Ab conjugation and Ab-enzyme conjugation.8. Enzyme linked Immunosorbant Assay(ELISA)9. Immunoprecipitation10. Isolation of Immunoglobulins and characterisation11. RIA.



7 TH SEMESTER

BT 701 DOWN STREAM PROCESSING


Module 1Role of downstream processing in biotechnology - Role and importance of downstream processing

in biotechnological processes - Problems and requirements of bioproduct purification. Economics of downstream processing in Biotechnology - cost cutting strategies -characteristics of

biotechnological mixtures – process design criteria for various classes of bioproducts (high volume, low value products and low volume, high value products) - physicochemical basis of bioseparation processes.

Module 2Primary separation and recovery processes.

Cell disruption methods for intracellular products - removal of insolubles - biomass (and particulate debris) separation techniques - flocculation and sedimentation - centrifugation and filtration methods.

Module 3Enrichment operations

Membrane-based separations - micro and ultrafiltration theory - design and configuration of membrane separation equipment – applications - precipitation methods (with salts, organic solvents, and polymers, extractive separations, aqueous two-phase extraction, supercritical extraction) - in situ product removal - integrated bioprocessing.

Product resolution fractionation.

Module 4Adsorptive chromatographic separations processes - electrophoretic separations (all electrophoresis

techniques including capillary electrophoresis) - hybrid separation technologies (membrane chromatography, electro chromatography etc)

Product polishing: gel Permeation Chromatography, dialysis, Crystallization.

References1. Belter PA and Cussler E, Bioseparations, Wiley.2. Product Recovery in Bioprocess Technology, BIOTOL series.VCH.3. Asenjo,J.M., Separation Process in Biotechnology ,Marcel Dekker Inc.




BT 702 Recombinant DNA Technology


Module 1rDNA methodologies

Introduction of recombinant DNA into a host (bacteria, plants & animals by various methods) – Transformation - in vitro packaging into phages – transsfection - reporter genes and gene targeting.

Recombinant selection and Screening - use of probes-RNA,cDNA,and DNA - nucleic acid hybridizations - southern,northern blotting - colony and plaque hybridization - Screening by immunochemicalmethods.

Module 2Expression of cloned genes:

Salient features of prokaryotic and eukaryotic expression systems - fusion proteins - secreted proteins - in vitro gene expression.

DNA amplification – Polymerase chain reaction (PCR) - basic reactions - inverse PCR - RT PCR – RACE -applications of

PCR.Gene modification:

Mutagenesis - deletion mutagenesis - oligonucleotide directed mutagenesis - PCR based mutagenesis - Site directed mutagenesis and its applications

Module 3DNA sequencing

Chemical method of Maxam & gilbert – enzymatic (diddeoxy chain termination) method of Sanger - automated sequencing.

DNA mapping and analysis of DNA sequencesRestriction mapping - DNA fingerprinting - chromosome walking - chromosome jumping

Module 4Safety aspects of recombinat DNA technology.

Applications of r-DNA technology: Diagnostics – pathogenesis - genetic diversity - RELP analysis and DNA finger printing -

Theraputic proteins, novel proteins, vaccines, antibodies, herbicide resistance, insecticides. Gene transfer techniques –

CaPO4-coprecipitation – electroporation – lipofection - microinjection Transgeneic technology

Transgenic mouse - transgenic fish – Antisense technology and applications

References2. Watson,J.D, Gliman,N, Recombinant DNA. Scientific American Books, W.H.Freeman and Co.New

York.3. Bernur,R,Pastrnek,J.J, Molecular Biology ,Principles and Applications in Recombinant DNA,

Panima Publishing Cooperation, New Delhi.




BT 703 PROTEIN ENGINEERING


Module 1Structure of proteins:

Primary structure and. its determination – secondary structure - prediction and determination of super secondary structures - protein folding pathways - tertiary structure and domain in proteins - quaternary structure - methods to determine tertiary and quaternary structures - post translational modifications

Module 2Structure function relationship of proteins:

DNA binding proteins - prokaryotic and eukaryotic transcription factors - DNA polymerases - Membrane proteins and receptors – bacteriorhodopsin - photosynthetic centres - epiderrmal growth factor - insulin and PDGF receptors and their interaction with effectors

Module 3Protein phosphorylation – immunoglobulins - Nucleotide binding proteins - enzyme serine proteases

– ribonuclease - lysozyme Module 4Protein engineering and protein design:

Protein data base analysis - methods to alter primary structure of proteins - Examples of engineered proteins - Protein design, principles and examples.

References1. Moody PCE, and AJ Wilkinson, Protein Engineering, IRL Press, Oxford.2. Creighton TE, Proteins, Freeman WH.




BT 704 ECONOMICS IN INDUSTRIES


Module 1Equivalence and cost comparison

Time value of money and equivalence – equations used in economic anlysis – compound interest as operator – unacost – Hoskold’s formula – Cost comparison – comparison with equal duration – comparison with unequal duration – common denominator of service lives – unacost and capitalized costDepreciation and taxes

Nature of depreciation, method of determining depreciation – straight line method, declining balance method, sinking fund method, declining balance method, double declining balance method, sum-of-digits method and units of production method – taxes and depreciation – comparison of depreciation methods, cost comparison after taxes

Module 2Capital requirements and cost of production for process plants

Equipment for process plants, cost indices: engineering news-record construction – cost index – material cost indices, labour cost index equipment costs – William’s six-tenth factorCapital requirements

Fixed capital investment and working capital estimation of capital investment – direct and indirect costs – Types of capital cost estimates – order of magnitude estimate, definitive estimate and detailed estimateCost factors in capital investment

Cost and installation of purchased equipment, insulation costs, instrumentation and control, piping, electric installations, building, yard improvements, service facilities, land, design engineering and supervision, construction expenses, contract fees, contingencies, start up expense – methods for estimating capital investmentEstimation of total product cost

Manufacturing costs – general expenses, direct production costs, fixed charges, plant overhead costs, administrative expenses, distribution and marketing expenses.

Module 3Continuous interest and discounting

Logic for continuous interest, continuous interest as an operator, uniform flow – Flow changing at an exponential rate, flow declining in a straight line to zero, discounting with improving performance – Uniflow capital recovery factor, capitalized cost, taxesBreak even and minimum cost analysis

Types of cost – variable and fixed costs – economic production charts – above 100% capacity, dumping non-linear, differential analysis of economic production charts.

Module 4Profitability investment equation, mathematical methods for profitability evaluation – payout time,

payout time with interest return on original investment, return on average investment, discounted cash flow and venture worthFinancial statement

Balance sheet and profit and loss account ratios that are used to compare the balance sheet and the profit and loss account.

References1. Jelen F C, Cost and Optimization engineering2. Peters and Timmerhaus, plant design and economics for chemical engineers3. Schweyer, Process Engineering Economics4. Tyler, Chemical engg cost estimation


5. Bhattacharya A.K., Principles and Practice of Cost Accounting, Wheeler PublishingSessional work assessmentAssignments 2x10 = 202 tests 2x15 = 30Total marks = 50


BT705(A) GENOMICS AND PROTEOMICS


Module 1Principles of gene Expression - Genome Mapping - Human Genome Project -Genomes of other

organisms - Role of genomics in Drug discovery and development - peptide nucleic acid technology.

Module 2Genomics in Biopharmaceutical Industry - Functional Genomes - Pharmacogenetics Genomics in relation to molecular diagnosis

Module 3 Molecular Therapeutic technologies. Gene Therapy - New Targets for drug discovery

Module 4

Proteomics:

Proteomic Techniques - Pharmaceutical Applications - Proteomics in drug discovery - in human.

Role of animal models in identification of genes for disorders knockout mice.

Refernces

1. S.Sahai, Genomics and Proteomics, Functional and Computational Aspects, Plenum Publications.




BT705(B) MOLECULAR MODELLING AND DRUG DESIGN


Module 1Empirical force fields molecular mechanisms : Bond Stretching - Angle Bending - Torsional I terms

- Out of plane bonding motions - Electrostatic interactions - Van der Waals , interactions - Effective pair Potentials - Hydrogen Bonding

Module 2Simulation of liquid water - Computer simulation methodsCalculation of thermodynamic properties - Phase space - Practical aspects of computer simulation -

Boundaries monitoring Equilibrium - Long range process - Analyzing results of simulation and estimating errors.

Module 3Molecular dynamics simulation methods.

Molecular Dynamics using simple modules - Molecular Dynamics with continuous potentials - Running Molecular Dynamics simulation - Constant dynamics - Time dependent properties - Molecular Dynamics at constant temperature and pressure. Drug metabolism

Physico chemical principles, radioactivity pharma kinetics. Action of drugs on human bodies..Important unit processes and their applications Bulk drug Manufacturers, Types of Reactions in Bulk drug Manufacture and Processes - Special Requirements for Bulk Drug Manufacture - Manufacturing principles.

Module 4Monte carlo simulation methods:

Metropolis methods - Monte Carlo simulation of molecules - Monte Carlo simulation of polymers - Calculating chemical potentials Monte Carlo or Molecular Dynamics. Molecular modelling to discover and design new molecules:

Molecular modelling in drug discovery - Deriving and using 3D Pharma cores - Molecular docking - Structure Based methods to identity lead components - Denovo ligand design.

References2. A.R.Leach., Molecular Modelling Principles and Applications, Longman.





BT705(C) BIOPHYSICS


Module 1Levels of structures in Biological macromolecules - Central questions in biophysics - Basic

strategies in biophysics - Conformational analysis: Forces that determine protein and nucleic acid structure, basic problems - polypeptide chains geometries - potential energy - calculations, observed values for rotation angles, hydrogen bonding, hydrophobic interactions and water. Structures ionic interactions, disulphide bonds.

Module 2Structural analysis of macromolecules: Prediction of proteins structure nucleic acids, general

characteristics of nucleic acid structure, geometries, glycosidic bond rotational isomers and those puckering backbone rotational isomers and ribose puckering backbone rotational isomers and ribose puckering forces stabilizing ordered forms, base pairing, base stacking tertiary structure of nucleic acids

Module 3Kinetics of ligand interactions: Biochemical Kinetics studies, uni molecular reactions, simple

bimolecular multiple intermediates, steady state kinetics, catalytic efficiency, relaxation spectrometry, riboriuclease as an example.

Module 4Techniques for the study of biological structure & function: Size and shape of macromolecules-

methods of direct visualization macromolecules as hydrodynamic particles- macromolecular diffusion- ultra centrifugation- viscometry x-ray crystallography determination of molecular structures, X-ray fibre diffraction electron microscopy neutron scattering- light scattering.

References1. Cantor R, Samuuel P.R. ,Biophysical Chemistry, W. H. Freeman & Co.




BT 705(D) FOOD BIOTECHNOLOGY


Module 1Technology of conventional and non-conventional fermentation based food products from cereals,

legumes, fruits, vegetables, milk, fish and meat Role of microorganisms in manufacture and spoilage of fermented products

Module 2Biotechnological processes in conventional and non-conventional fermentation - secondary

fermentation of waste generated in selected food fermentationPilot and large-scale fermentation, continuous and batch cultures process monitoring and control

Module 3New and modified carbohydrates, lipids, polysaccharides, proteins and nucleotides - New protein

foods : SCP, mush room, food yeasts, algal proteins - Production of microbial biomass and economic aspects.

Module 4Genetically modified and transgenic food - development processing - nutrition and aspects -Protein

engineering in food biotechnology - Biotechnology of food preservation - Genomics for food biotechnology - Food biotechnology additives like colors, flavours,and vitamins.

References1. Roger A., Gordan B.,and John T.,Food Biotechnolgy.2. Lindsay,Willis ,Biotechnology, challenges for the flavor and food industries, Elsvier Applied

Science.3. Stanbury,P.F. and Whitaker A, Principles of Fermentation Technology, Pergamon Press.



BT 706 SEMINAR

Each student can take seminars on topics of interest in the field, which will be assessed by the faculty members.Sessional work assessmentPresentation = 20Discussion = 10Report = 20Total marks = 50


BT 707 BIO PROCESS LAB II

3 hours per week

1. Recovery of products2. Extra cellular enzyme production and purification3. Production of intracellular products4. Cell disruption techniques, solid –liquid separation methods5. Filtration, sedimentation, centrifugation, product enrichment operations. 6. Chromatographic techniques7. Ultrafilteration, two phase aqueous extraction8. Product crystallization and drying.


BT 708 : PROJECT

4 hours practical per week

This project is for a duration of two semesters - each student group (not more than 5 members in a group) is

expected to develop a complete project - the seventh semester is mainly for reference and design of

experiments- an interim report is to be submitted at the end of the semester - the assessment may be made

individually and in groups

Sessional work assessmentDesign = 25Attendance = 10Report = 15Total marks = 50


8 TH SEMESTER BT 801 INSTRUMENTATION AND PROCESS CONTROL


Module 1Functions and elements of instruments – static and dynamic characteristics of instruments

– sensing elements – transducers – measuring and transmission methods – indicating and recording means – piping and instrumentation diagrams.Temperature measurement

Working principle of thermocouple – resistance thermometers – thermistors – optical and radiation pyrometers.

Module 2Pressure Measurement

Working principle of manometers – Bourdon gauge – bellows – type gauge and vacuum measuring instrumentsFlow Measurement

Use of obstruction type meters – variable area meter – pressure probe and positive displacement type meters.

Liquid level measurements in open and pressure vesselsMeasurement of viscosity, conductivity and pH.

Module 3General principles of process control

Basic control elements – degree of freedom and fixing of control parametersSimple system analysis - Laplace transforms and transfer functions block diagrams – linearization First and higher order systems – interacting and non-interacting systems – distributed and lump parameter systems – dead time

Module 4Control systems

Different modes of control and their basic characteristics – controller characteristics – process characteristics

Optimization of control system response – stability analysisIntroduction to advanced control techniques as feed forward feedback, cascade, ratio,

adaptive and digital computer controlInstrumentation and control of bioreactors and fermentor

Text/Reference1. Eckman D P: Industrial Instrumentation, Wiley eastern Ltd2. Kerk F W et al: Instrumentation, Wiley & sons3. D R Coughnower and L B Koppel: Process system analysis and control, McGraw Hill

Kogakusha4. A Pollard: Process Control for Chemical and Allied Industries, Heinemann Education Co.


University examination pattern


Q I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15marks from module III with choice to answer any oneQ V - 2 questions A and B of 15marks from module IV with choice to answer any one

BT 802 INDUSTRIAL MANAGEMENT


Module 1

Principles of management - management functions - planning - organising - organisation structures - span of control - delegation - directing - leadership and motivation - controlling - decision making - single stage decision making under risk - multistage decision making - decision tree - decision making under uncertainty - equally likely, minimax and maximin criteria

Module 2 Operation management - production systems and functions - product design and selection - concept of total quality management and ISO 9000 system of standards - concept of supply chain management - project management - projects and management - network analysis - critical path method (CPM) network - finding critical path - slacks - crashing (time-cost trade off) - PERT network

Module 3 Marketing management - concept of market and marketing - marketing function - marketing mix - market research - advertising and sales promotion - human resources management - manpower requirement analysis - recruitment and training - job analysis - job evaluation - wages and incentives

Module 4 Financial management - objectives/functions - concept of time value of money - basics of financial accounting - profit and loss account - balance sheet - costing - elements of costs - cost sheet - allocation of overheads - break-even analysis depreciation - significance and methods of depreciationText books

1. Mazda F., Engineering Management, Addison Wesley2. Buffa E.S. & Sarin R.K., Modern Production/Operations Management, John Wiley3. Chase R.B., Aquilano N.J. & Jacobs F.R., Production and Operations Management Manufacturing

and Services, Tata McGraw Hill Publishing Company Limited4. Kolter P., Marketing Management: Analysis, Planning, Implementation and Control, Prentice Hall

of India Private Limited5. Venkata Ratnam C.S. & Srivastava B.K., Personnel Management and Human Resources, Tata

McGraw Hill Publishing Company Limited6. Pandey I.M., Financial Management, Vikas Publishing House Pvt. Ltd




BT 803 PLANT BIOTECHNOLOGY & TISSUE CULTURE


Module 1An outline of molecular biology: DNA Replication, translation, transcription, and fundamentals of

recombinant DNA technology, Gene regulation.Agrobacterium and plant genetic engineering: Agrobacterium mediated gene transfer and cloning. Types of plant vectors and their use in gene manipulation.

Module 2Plant viruses: Classification diagnosis - remedy - viruses as a tool to deliver foreign DNA.Developmental aspects of rhizobium: Legume Symbiosis, Symbiotic Nitrogen fixation, Regulation

of nif and nod gene

Module 3Molecular aspects of disease susceptibility and resistance: Transposable elements, factors

influencing disease resistance and susceptibility RFLP.Transgenics Herbicide tolerance insect resistance, viral resistance stress tolerance development of

disease resistance plants by introducing Bacillus thuringiensis genes.

Module 4Fundamentals of plant tissue culture, plant regeneration ,organogenesis. Role of tissue culture in

rapid clonal propagation, production of pathogen free of pathogen free plants and synthetic seeds. Protoplast technology: isolation, culture and plant regeneration, protoplast fusion, identification and characterization of somatic hybrids, applications of protoplast technology.

References1. Dodds J.H., Plant Genetic Engineering, Cambridge University Press.2. Mantal S.H., Mathews J.A., Mickee R.A. Principles of Plant Biotechnology .An Introduction to

Genetic Engineering in Plants., Blackwell Scientic Publications.



.


BT 804 METABOLIC ENGINEERING


Module 1Introduction - Jacob Monod model, catabolite regulation, glucose effect, camp deficiency, feed back

regulation, regulation in branched pathways, differential regulation by isozymes, concerted feed back regulation. Cumulative feed back regulation. Amino acid regulation of RNA synthesis. Energy charge regulation, amino acid regulation of RNA synthesis, energy charge, regulation, permeability control passive diffusion, facilitated diffusion, active transport group transportation

Module 2Synthesis of primary metabolites: Alteration of feed back regulation, limiting accumulation of end

products feed back, resistant mutants, alteration of permeability.Biosynthesis of secondary metabolites: Precursor effects, prophophase, idiophase relationship,

enzyme induction, feed back regulation, catabolite regulation by passing control of secondary metabolism, producers of secondary, metabolites.

Module 3Bioconversions: Advantages of Bioconversions, specificity, yields, factors Important to

bioconversions, regulation of enzyme synthesis, mutation, permeability, co-metabolism, avoidance of product inhibition, mixed or sequential bioconversions, conversion of insoluble substances.

Module 4Regulation of enzyme production: Strain selection, improving fermentation, recognizing growth

cycle peak, induction, feed back repression, catabolite repression, mutants resistant to repression, gene dosage.

References2. Wang,D.I.C., Cooney C.L., Demain AL, Dunnil.P., Humphery A.E. Fermentation and Enzyme

Technology, John Wiley and Sons.




BT 805(A) CHROMATOGRAPHIC SEPARATION


Module 1Introduction

Classification of techniques – distribution coefficient – retention chromatography – sorption mechanisms – retention parameters – factors affecting retention – qualitative and quantitative aspects of chromatography – peak shape sorption isotherms – column efficiency – band broadening processes – selectivity and resolution

Module 2Classical chromatography

Stationary phases – application of ion-exchange size exclusion – Thin Layer Chromatography (TLC) – HPTLCChiral chromatography

Principles – types of chromatography – scopes and limitations – applications – capillary electrophoresis

Module 3Gas chromatography

Introduction – instrumentation – columns – qualitative and quantitative aspects of gas chromatography – quantitative analysis of GC

Module 4High performance liquid chromatography

Introduction – design of typical HPLC machine – types of columns – application

Reference1. Sewell P A, Clarke B, Chromatographic Separartions, John Wiley and Sons, 19912. Lindsay B, High Performance Liquid Chromatography, John Wiley and Sons




BT 805(B) TRANSPORT PHENOMENA


Module 1Transport properties

Theory of viscosity of gases and liquids – thermal conductivity of gases and liquids – theory of diffusion in gases and liquids

Module 2Shell momentum balances

Equation of continuity – momentum equation – energy for three dimensional flow – application of differential equation of fluid flow to specific problems

Module 3Shell energy balances

Boundary conditions and temperature distribution in solids and laminar flow – free and forced convectionMass transport

Molar fluxes – Fick’s law of diffusion – diffusion through a stagnant gas film – diffusion into a falling film

Module 4Analogy between momentum, heat and mass transfer – mechanism of interphase transport – two film

theory – penetration theory Application of transport phenomena in bioprocess engineering

Reference1. Bird Stewart and Lightfoot: Transport Phenomena




BT 805(C) NUMERIC ANALYSIS


Module 1Errors in numerical calculation – sources of errors – significant digit – numerical solution of polynomial and transcedental equation – bisection method – regular falsi method – newton rapson method – method of iteration – rate of convergence of these methodsSolution of system of linear algebraic equationExact method – gauss elimination – Crout’s triangularization method – iterative methods – Gauss-Jacobi and Gauss – Seidel iteration methods – relaxation methods

Module 2Polynomial interpolation – Lagrange interpolation polynomial – divided differences – Newton’s

divided difference intrapolation polynomial – finite differences – operators – E, K Gregory-Newton forward and backward difference polynomials – Central differences – Stirling’s interpolation formulaNumerical differentiation

Differential formulae in the case of equally spaced pointsNumerical integration

Trapezoidal and simpson’s rules – compounded rules – errors of interpolation and integration formula

Module 3Numerical solution of ordinary differential equations – single step method – Taylor series methods –

Euler’s method – modified Euler’s method – Picard’s iteration methods – Runga-Kutta method (2nd, 3rd and 4th

order formula – derivation not required) - multi-step methods – Milne’s predictor-corrector formula – solution of linear differential equation with constant coefficients – numerical solution of boundary value problems – ordinary differential equation – method of finite differences – defenote difference methods for solving two dimensional Laplace equation for a rectangular region – finite difference method of solving the

heat equation = 2 with IC and BC

Module 4Single Variable Optimization

Analytical methods – necessary and sufficient conditions for optimum numerical methods – direct search, direct search with acceleration, gradient search, dichotomous search, Fibonacci search, dolden section methodMulti variable optimizationDirect substitution methods - Numerical methods – direct search methods – gradient search methods

References1. E Kreyszig, Advanced engineering mathematics (5th ed)2. SS Sastry, Numerical mathematical analysis (7th ed.)3. Rao SS, Optimization- theory and application


University examination patternQ I - 8 short type questions of 5 marks, 2 from each moduleQ II - 2 questions A and B of 15marks from module I with choice to answer any oneQ III - 2 questions A and B of 15marks from module II with choice to answer any oneQ IV - 2 questions A and B of 15marks from module III with choice to answer any one


Q V - 2 questions A and B of 15marks from module IV with choice to answer any one

BT 805(D) SAFETY IN PROCESS PLANTS


Module 1Origin of process hazards, laws, codes, standards, case history

HazardsChemical, mechanical and physical – health hazard of industrial substances

Module 2Explosion and hazards due to chemical reaction – Identification of hazards – fire and

explosion hazard rating of process plants – HAZOP and HAZAN – importance of risk analysis

Module 3Consequence analysis – modeling of fire , explosion and toxic gas dispersionEvent probability and failure frequency analysis – individual risk and societal risk – reliability and

risk analysis

Module 4Designing for safety – safety training – emergency planning and disaster management – case studies

References1 G L Wells: Safety in Process Plant Design, IchemE/Godwin2 F P Lees: Loss Prevention in Process Industries, Butterworth3 A E Green: High Risk Technology, Wiley




BT 806 GENETIC ENGINEERING LAB

3 hours per week

1. Preparation of DNA-genomic and plasmid.2. Agarose gel electrophorosis of DNA3. Restriction enzyme digestion 4. Preparation of competent cells5. Gel electrophoresis of proteins6. Induction of Lac operon (expression of beta-galactosidase and assay).7. Cloning of DNA into plasmid vector.

Sessional work assessmentLab practical and record = 15Test/s = 10Total marks = 25

BT 807 PROJECT

7 hours per weekThis project is the continuation of the seventh semester project - the eighth semester is for the development of

the project-a detailed report is to be submitted at the end of the semester - the assessment may be made

individually and in groups

Sessional work assessmentDesign & development = 40Testing and installation = 40Report = 20Total marks =100

BT 808 VIVA VOCE

There is only university examination for this - the university will appoint examiners for conducting the viva

voce examination - the examiners will ask questions from subjects studied for the B.Tech course, project and

seminar reports of the student - the relative weightages should be as follows

Sessional work assessmentSubjects ` = 40Project = 40Seminar = 20Total marks =100


Documents

Are You suprised ?220.225.200.252/photoupload/syllabus/sybt.old.doc · Web viewQ I - 8 short type questions of 5 marks, 2 from each module Q II - 2 questions A and B of 15marks from