Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for

inflammation

by Jesper Hjortnaes, Jonathan Butcher, Jose-Luiz Figueiredo, Mark Riccio, Rainer H. Kohler, Kenneth M. Kozloff, Ralph Weissleder, and Elena Aikawa

EHJVolume 31(16):1975-1984

August 14, 2010

Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: [email protected]

Induction of osteogenesis in carotid arteries and aortic valves of apoE−/− and chronic renal disease apoE−/− mice, detected by intravital fluorescence microscopy.

Jesper Hjortnaes et al. Eur Heart J 2010;31:1975-1984


Loss of bone mineral density and alterations in microarchitecture in mouse femurs, detected by 3D micro-computed tomography and molecular imaging.



Inverse correlation of bone tissue mineral density with arterial and aortic valve calcification.



Induction of inflammatory signal in carotid arteries and aortic valves of apoE−/− and chronic renal disease apoE−/− mice, detected by intravital fluorescence microscopy.



Correlation of long bone inflammation with osteogenic activity.



Relationship between bone osteogenic activity and inflammation.



Schematic presentation of a hypothetical model on the paradoxical relationship between cardiovascular calcification and bone mineral loss, associated with local and systemic

inflammation.



Documents

Arterial and aortic valve calcification inversely correlates with osteoporotic bone remodelling: a role for inflammation by Jesper Hjortnaes, Jonathan