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Copyright © 2009 Thomas F. Plaut M.D. May be copied for personal use. Contact [email protected] for permission to publish. ASTHMA CLINICIANS WORK TOO HARD Thomas F. Plaut, MD Most asthma clinicians work too hard. They could make this job easier by enlisting patients as their colleagues. After practicing pediatrics for 20 years, I spent 25 years developing materials and methods for improving asthma care. The Expert Panel Report 3 (EPR‐3) 1 states that patient education should occur at all points of care including clinic settings, Emergency Departments, hospitals, pharmacies, schools and patient homes. Thousands of professionals have used my methods materials in these venues to care for asthma more efficiently and effectively. My major techniques include the use of: Asthma booklets Peak flow monitoring Asthma diaries Asthma action plans Asthma learning tools ASTHMA BOOKLETS. When I published One Minute Asthma: What You Need to Know in 1991, Dr. Albert Sheffer, chair of the 1991 NHLBI Expert Panel on Asthma, called it “… accurate, clear and concise… an ideal guide for patients and parents starting to learn about asthma.” The eighth edition, published in 2008, is the nation’s most comprehensive and current asthma booklet. Clinicians can reduce their workload, increase patient satisfaction and increase their revenue by using One Minute Asthma. In 2001 I encouraged a pediatric group to use the booklet in the exam room and to assign reading between visits. This helped their patients learn more effectively and reduced the length of a 15‐minute visit by three minutes. They calculated that this would enable them to increase their practice income by $14,000 each year. 2 After patients learn basic information from One Minute Asthma a professional can provide additional information that is specific to them or their child. For example, when you decide to prescribe an inhaled steroid during an office visit the patient doesn’t realize that an inhaled steroid is the most effective medicine used to treat asthma. They may have heard that steroids can interfere with a child’s growth in height or cause osteoporosis. They don’t know that taking an inhaled steroid daily causes only a tiny fraction of the problems caused by oral steroids. They do not know that, if they decline to use inhaled steroids, their chance of needing treatment with an oral steroid will increase greatly. A pediatrician can ask a parent to read one page about inhaled steroids in the exam room while he leaves to see another patient. When he returns he will have a much easier time discussing this complex subject. The same is true for other medicines and devices. There is a lot of detail to be covered when explaining the use of a peak flow meter, a holding chamber, a dry powder inhaler or a compressor driven nebulizer. Each of these topics is covered in one or two pages of One Minute Asthma.

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Copyright©2009ThomasF.PlautM.D.Maybecopiedforpersonaluse.Contactjtplaut@pedipress.comforpermissiontopublish.

ASTHMACLINICIANSWORKTOOHARDThomasF.Plaut,MD

Mostasthmacliniciansworktoohard.Theycouldmakethisjobeasierbyenlistingpatientsastheircolleagues.Afterpracticingpediatricsfor20years,Ispent25yearsdevelopingmaterialsandmethodsforimprovingasthmacare.TheExpertPanelReport3(EPR‐3)1statesthatpatienteducationshouldoccuratallpointsofcareincludingclinicsettings,EmergencyDepartments,hospitals,pharmacies,schoolsandpatienthomes.Thousandsofprofessionalshaveusedmymethodsmaterialsinthesevenuestocareforasthmamoreefficientlyandeffectively.Mymajortechniquesincludetheuseof:

• Asthmabooklets• Peakflowmonitoring• Asthmadiaries• Asthmaactionplans• Asthmalearningtools

ASTHMABOOKLETS.WhenIpublishedOneMinuteAsthma:WhatYouNeedtoKnowin1991,Dr.AlbertSheffer,chairofthe1991NHLBIExpertPanelonAsthma,calledit“…accurate,clearandconcise…anidealguideforpatientsandparentsstartingtolearnaboutasthma.”Theeighthedition,publishedin2008,isthenation’smostcomprehensiveandcurrentasthmabooklet.

Clinicianscanreducetheirworkload,increasepatientsatisfactionandincreasetheirrevenuebyusingOneMinuteAsthma.In2001Iencouragedapediatricgrouptousethebookletintheexamroomandtoassignreadingbetweenvisits.Thishelpedtheirpatientslearnmoreeffectivelyandreducedthelengthofa15‐minutevisitbythreeminutes.Theycalculatedthatthiswouldenablethemtoincreasetheirpracticeincomeby$14,000eachyear.2AfterpatientslearnbasicinformationfromOneMinuteAsthmaaprofessionalcanprovideadditionalinformationthatisspecifictothemortheirchild.Forexample,whenyoudecidetoprescribeaninhaledsteroidduringanofficevisitthepatientdoesn’trealizethataninhaledsteroidisthemosteffectivemedicineusedtotreatasthma.Theymayhaveheardthatsteroidscaninterferewithachild’sgrowthinheightorcauseosteoporosis.Theydon’tknowthattakinganinhaledsteroiddailycausesonlyatinyfractionoftheproblemscausedbyoralsteroids.Theydonotknowthat,iftheydeclinetouseinhaledsteroids,theirchanceofneedingtreatmentwithanoralsteroidwillincreasegreatly.Apediatriciancanaskaparenttoreadonepageaboutinhaledsteroidsintheexamroomwhileheleavestoseeanotherpatient.Whenhereturnshewillhaveamucheasiertimediscussingthiscomplexsubject.Thesameistrueforothermedicinesanddevices.Thereisalotofdetailtobecoveredwhenexplainingtheuseofapeakflowmeter,aholdingchamber,adrypowderinhaleroracompressordrivennebulizer.EachofthesetopicsiscoveredinoneortwopagesofOneMinuteAsthma.

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Readinginthewaitingroomcanalsostreamlinevisits.IstudiedtheuseofOneMinuteAsthmainthewaitingroomofeightpractices.3Areceptionistgavethebooklettoeachnewasthmapatient.Alabelonthefrontcoverdirectedthemtoreadfourpagesdescribingasthmacontrol,asthmamedicinesandchangesintheairwayduringanepisode.Patientswhoreadthesepagesinthewaitingroomaskedbetterquestionsandhadamorefocusedvisitthancontrols.Thistacticincreasedofficeefficiencyyetcostnomoneyorstafftime.PEAKFLOWMONITORING.Thepeakflowscore4isanobjectivemeasureofairflow.Itisthefastestspeedatwhichthepatientcanblowairout.Peakflowcanbemeasuredwithasmallhandheldmeter.Itfrequentlydetectsadropinairflowbeforeadoctorcanhearawheezewithastethoscope,addingimportantobjectiveinformationtothehistoryandphysicalexam.Ihaveusedapeakflowmeterformorethan25yearstomonitorandtreatasthmaintheofficeandathome.Instructionsare:

• Movethepointertozero.• Standup,holdthemeterstraight.• Openyourmouthwideandslowlybreatheinasmuchairasyoucan.• PlacethemouthpieceFLATonyourtongue.• Closeyourlipssnuglyaroundit.• Blowoutashardasyoucan.• Movethemarkertozero.• Waitatleast15seconds.• Recordthebestofthreetries.

Youcanusepeakflowscorestoguidetreatmentwithnebulizedalbuterolinyouroffice.Thescorewillincreaseasthechildimproves.Thechangeisobvious.Astethoscopewillnotgivethesameclear‐cutinformationbecausewheezingmaydecreaseastheairwaysopenORastheyclose.Youshouldcheckpeakflowfiveminutesaftereachalbuteroltreatmenttoassessprogressand30minutesafterthefinaltreatmenttomakesurethattheimprovementissustained.Apeakflowscorewillbefalselyhighifpatientsblockairflowwiththeirlips,theirtongueortheirglottis.Whentheblockisremoved,airwillshootoutunderhighpressure.5The“spit”orthe“peashooter”techniquecanraisepeakflowby300pointsoverthescoreobtainedusingpropertechnique.Sixsubjectsblewpeakflowwitheachof10differentpeakflowmeterbrandsusingthespitandpeashootermaneuvers.Whentheyusedimpropertechniqueallincreasedtheirpeakflowscoresby100to300liters/min.inatleasteightoftenbrands(Plaut,TF.personalobservation).Whenapatient,whowaspreviouslyabletoblowanormalscore,blowsaverylowscoreorisunabletomovethemarker,shemayhaveaveryseriousproblem.Neverblamealowscoreonpoortechniqueoreffort.Youshouldbeabletocorrecthertechniqueonthenextblow.Ifthescoredoesn’tincrease,thepatient’sconditionmaybeworsethanyouthink.Youmaybedealingwithfatiguedrespiratorymuscles,alifethreateningemergency.

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Allofmypatientsagefiveandoverchecktheirpeakflowathome.Thepersonalbestscoreisthereferencepointformakingtreatmentdecisions.Itisthehighestscoreapatientcanblowwhen:

• theyarehavingnosignorsymptomofasthma,• havetakenamoderatedoseofaninhaledsteroidandotherneededmedicinesfortwo

months,and• theirscoreshavestayedattheirhighestlevelforaweek.

Patientscanusuallyestablishtheirpersonalbestwithinamonthoffulltreatmentwithaninhaledsteroid.BeforethattimeIusetheirhighestscoreorapredictedscorefromatableofaverages,whicheverishigher.Iadjustthepersonalbestscorewheneverthepatientblowsahigherscoreontwodifferentdays.Achild’spersonalbestincreaseswithgrowthinheight.TheinstructionsforestablishingthepersonalbestinEPR‐3andmanyotherpublicationsareflawed.EPR‐3identifiesthepersonalbestasthe“highestpeakflownumberyoucanachieveoveratwoweekperiodwhenyourasthmaisundergoodcontrol.Goodcontroliswhenyoufeelgoodanddonothaveanyasthmasymptoms.”6However,somepeoplecan’tnoticesymptomswhentheirairflowissignificantlyreduced.Fifteenpercentof82patientsinonestudywerenotabletosenseareductioninairflowunlessitwasgreaterthan50percentoftheirpredictedvalue.7Astudyoftreatedhospitalizedpatientsfoundthattheywerenotabletofeelsymptomswhentheirpulmonaryfunctionwas50percentofpredicted.8Anasthmaactionplanbasedonafalselylowpersonalbestmayleadtotardyorinadequatetreatment.ASTHMADIARIES.Anasthmapeakflowdiary(seeFig.4)givestheclinicianandthepatientorparentagoodunderstandingofrecenthistory.Youcanscanatwo‐weekrecordinabouttwominutes.Mypatientsoftenbringindiariesspanningseveralmonths.TheinformationrecordedinthePedipressAsthmaPeakFlowDiaryismoreaccurateanddetailedthanapatientcanrecallorthancanberecordedinanyotherdiary.Iftheypayattentiontothesedetails,clinicianscanprovidebettercare.Parentsandpatientsusethediarytolearnaboutasthmaandtoguidetheirtreatmentathome.AcombinationoffivedesignfeaturesisuniquetothecurrentPedipressAsthmaPeakFlowDiary.9

• Thegraphicformatdisplaystrendsbasedonthepersonalbest.Thisiseasiertoanalyzethanaseriesofnumbers.

• Twoyellowzonesidentifymildandmoderateepisodes• Thereisamplespacetorecordsigns• Relationshipsamongtriggers,medicines,peakflowandsignsareeasytosee.• Coloredzoneshighlightthechangefromonetreatmentzonetoanother.

Thefourzonesnotedonthediaryare:

• Greenzone,80‐100percentofthepersonalbest.Thisindicatesthatcurrenttreatmentisadequate.

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• Highyellowzone,65‐80percentofthepersonalbest.Thisindicatesamildepisode• Lowyellowzone,50‐65percentofthepersonalbest.Thisindicatesamoderateepisode.• Redzone–lessthan50%ofthepersonalbest.Thisindicatestheneedforemergency

treatment.

Figure 1. The Asthma Peak Flow Diary

ThesampleAsthmaPeakFlowDiarydisplayedaboveandinOneMinuteAsthma10showsapatientwhohasapersonalbestpeakflowof650.Thetopofhishighyellowzoneis520.Thetopofhislowyellowzoneis420andthetopofhisredzoneis325.Peakflowscoresbeforebronchodilatorarerecordedwitha0.ThescoresafteralbuterolaremarkedwithanX.Whenyouconnectthe0sortheXsyoucanseeatrend.Thenameanddoseofeachmedicineareenteredintheleftcolumn.Acheckmarkindicatesthatadosehasbeengiven.Thescoresoftheasthmasignsshouldbeconsistentwiththepeakflowscore.Ifnot,youneedtodeterminethereason.Mypatientsrecordtheirpeakflow,signs,medicines,triggersandnotableevents(suchasanupperrespiratoryinfection,exposuretotobaccosmokeoratriptothezoo)eachmorninguntiltheyhavebeeninthegreenzonefortwomonths.Theycontinuerecordingdailyifthediary

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helpsthemmanagetheirasthmaorbecauseitremindsthemtotaketheirmedicinesoridentifytriggers,otherwisetheystop.Theyrestartrecordingwhentheyhaveanysignorsymptomofasthma,atthefirstsignofacold,whentheyenterathreateningarea,goonvacationandfortheweekbeforetheyseeme.Theyusuallyrecorddataintheirdiariesabout30dayseachyear.FifteenyearsagoIwasinvitedtospeakabouttheuseofpeakflowandasthmadiariestotheallergystaffatamajorteachinghospital.MostphysiciansintheroomknewmoreaboutasthmathanIdid.Oneallergistaskedmehowmanyofmypatientskeepadiary.“Allofthem,”Ianswered.“Howdoyoumakethemkeepadiary?”heasked.ItoldhimthatIcouldn’tmakemypatientsdoanything.Theyuseadiarybecausetheyfindithelpsthemincreasetheirunderstandingofasthma.Coupledwithanasthmaactionplan,thediaryenablesthemtotreatmostepisodesathome.Manydoctorssaythattheirpatientswon’tkeepadiary.Isitpossiblethatthesedoctors:

• failtopointoutthebenefitsofusingadiary,• failtolookatthediarysheetthatthepatientbringsin,• failtousethedatainthediarytoincreasethepatient’sunderstandingor• failtorelatethedatainthediarytoanactionplan?

Adiaryisanextremelyhelpfultoolasphysicianspartnerwithpatientsintheircare.The1997NHLBIGuidelinesfortheDiagnosisandManagementofAsthmadisplayedasinglediary.11Thatdiarywasfirstpublishedinmybook,ChildrenwithAsthma:AManualforParents.12ThecurrentEPR‐313notesthat“Patientsdetailedrecallofsymptomsdecreasesovertime,thereforetheclinicianmaychoosetoassessovera2‐week,3‐week,or4‐weekrecallperiod.”EPR‐3mentionsadiaryonsixseparatepagesbutdoesn’tdisplayoneormentionthatpatientswhokeepadiaryhavefarbetterrecallthanthosewhodon’t.PedipressdiarieshavebeentranslatedintoSpanish,depictedinseveralarticles14,15,16,17,18,19andbooks20,21,22andpurchasedforusebythousandsofprofessionals.ASTHMASIGNSDIARY.Patientslessthanfiveyearsofagecan’tblowaconsistentpeakflow.IdevelopedtheAsthmaSignsDiary(seeFig2)tohelpparentsofyoungchildrenlearnaboutasthmaandmanageepisodesathome.Signsaremoreaccurateandreliablemarkersthansymptoms.Theyareobjectiveandcanbescoredbyanobserverusingaprecisescale.InconstructingtheAsthmaSignsDiary,Ichosesignsthatarecommon,appearearly,changewiththeworseningorimprovementofanepisodeandareeasytoscore.Theyarecough,wheeze,suckinginthechestskinandincreaseinbreathingrate.PleaseseethescoringsystemontherightsideoftheAsthmaSignsDiary.23Atotalsignsscorebetween1and4fallsintheHighYellowZone(mildepisode);atotalbetween5and8isintheLowYellowZone(moderateepisode)and9oroverisintheRedZone(severeepisode).EPR‐3notes“Itisoftendifficultforphysiciansandparentstoassesstheseverityofanasthmaepisodeinaninfantorayoungchild.”24Thisstatementistrueifthesephysiciansandparents

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don’tknowhowtoscorethefoursignsofasthma.Oncetheylearn,theycaneasilyassesstheseverityofanepisode.Toprovethis,trytoscoreayoungchildwhois:coughingtwiceaminute,wheezingthroughoutexhale,suckinginthechestskinslightlyandhasaslightincreaseinbreathingrate.Itisnotdifficulttocalculatethatthetotalscoreisseven,whichplaceshiminthelowyellowzone.

Figure2.TheAsthmaSignsDiary

.Parentsneedtoknowhowtoassesstheirinfantoryoungchildinordertostarttreatmentearly.Theyneedguidancefromtheirdoctorastheylearn.Thisknowledgeisparticularlyimportantbecauseinfantsandyoungchildren:

• don’tcomplain,• can’tdescribetheirsymptomsand• getintotroublemorequicklybecausetheyhavesmallairways.• arenotoldenoughtouseapeakflowmeter.

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ASTHMAACTIONPLANS.Agoodasthmaactionplan25(Seefigures3and4)willtellpatientsandparentswhattodoineveryasthmasituation.Whento:

• reduceactivity,• changemedicinedose,• addamedicine,• callthedoctorand• gototheER.

Theplanshouldbeclearenoughsothatpatientsandparentswillrarelyneedtocallforadvicebetweenvisits.Itcanbebasedonpeakflowscoresorthefoursignsofasthma.26Eachplancallsforearlyactionateachlevelofanepisode’sseverity.Youcandownloadandcustomizetheseplansfromwww.pedipress.comforuseinyouroffice.

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Figure3.ThePeakFlowAsthmaActionPlan

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Figure4.TheSignsAsthmaActionPlan

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Abasicasthmaactionplanforpersistentasthma27mayincludethefollowing:

• Greenzone(maintenance):Takeaninhaledsteroidorothercontrollerdaily.Takealbuterolbeforestrenuousexerciseorwhenincontactwithatrigger.

• Highyellowzone:Avoidtriggers,givealbuterolonetofivetimesadayasneeded,startaninhaledsteroidorquadruplethecurrentdose.

• Lowyellowzone:Continuehighyellowzonemedicines.Givefourpuffsofalbuteroltoseeifpeakfloworsignswillenterthehighyellowzoneandstaythereforfourhours.Ifnotthepatientisstuckandneedstostartprednisone.

• Redzone:Ifpatientisstuckinredzoneafterfourpuffsofalbuterol,giveadoseofprednisoneandgotoER.

Ifsignsorsymptomsoccurwhenpeakflowisingreenzone,eitherthepersonalbesthasbeensettooloworthesmallairwaysareinflamed.Thelatterdoesnotreducepeakflow.Ineithercasetheparentshouldfollowthehighyellowzoneplan.Thepersonalbestshouldtheneitherbeconfirmedorrecalculated.ASTHMALEARNINGTOOL(ALT)Idesignedthistooltohelpalliedhealthprofessionalslearnbasicfactsaboutasthma.TheALTisfree,effectiveandtakes30to90minutes.Morethan200nurses,studentnurses,schoolnurses,pharmacistsandrespiratorytherapistshavedownloadedtheALTfromwww.pedipress.comorreceivedahardcopyfromacolleagueoraninstructor.Theyanswered40questionsandthenlookeduptheanswersinOneMinuteAsthma.Themediantimeforansweringthequestionswas30minutesandforlookinguptheanswerswas20minutes.Ninety‐eightpercentsaiditwasworththetimetheyspent.Almostallnamedatleastonethingtheylearnedthatwouldhelpthemteachotherstocareforasthma.PracticesthataskstafftousethewordsandconceptsintheALTandOneMinuteAsthmaimprovecommunicationamongstaffandwiththeirpatients.Useofseveraltermswiththesamemeaningoftencausesconfusion.Forexample,thereareatleasteighttermsforalbuterol:quickrelief,reliever,rescue,fastactingbeta‐agonist,quickactingbetaagonist,shortactingbetaagonist,ProventilandVentolin.Patientswhohearmorethanonetermforalbuterolmaythinkthattheyaredifferentmedicines.Theymaythinkthatoneclinicianischangingthemedicinethatanotherprescribed.SUMMARYHealthprofessionalscanusefivesimpletoolstoimprovetheefficiencyandeffectivenessoftheirasthmacare.

• Askpatientsandparentstoreadapageortwofromanaccurateandcurrentasthmabookintheexamroom,thewaitingroomandbetweenvisits.

• Teachpatientsandparentshowtouseapeakflowmetertolearnaboutandmonitorasthma.

• Teachpatientsandparentshowtouseacomprehensiveasthmadiary.

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• Usefour‐zoneasthmaplansbasedonpeakfloworasthmasignsscorestoguidetreatmentintheofficeandathome.

• EmploythefreeAsthmaLearningTooltoincreasestaffknowledgeandimprovecommunicationintheirpractice.

Professionalswhousethesetoolsareabletoprovidemoreeffectivecare,increasepatientsatisfactionandboostpracticerevenue.Endnotes 1 EPR‐3:ExpertPanelReport3:GuidelinesfortheDiagnosisandManagementofAsthma.2007,NIHPublicationNumber08‐

5846.Availableat:http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm.AccessedJuly27,2009. 2Plaut,TF,Hartman,L.Asthmadistancelearningprogramforstaffincreasespracticeeffectivenessandrevenue.Annalsof

AsthmaAllergyandImmunology.2003.Vol.92,Jan.2004,No.1,pages109‐110

3Plaut,TF.AsthmaEducationintheWaitingRoom.AnnalsofAsthmaAllergyandImmunology.Vol.90,No.1,Jan.2003,page

141

4Ibid.28‐31.

5StrayhornV,Leeper,K,TolleyE,SelfT.ElevationofPeakExpiratoryFlowbya“Spitting”Maneuver.CHEST.1998:1134‐46.

6NationalInstituteofHealthPublication.EPR‐3:ExpertPanelReport3:GuidelinesfortheDiagnosisandManagementof

Asthma.2007:122.Availableat:http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm.AccessedJuly2,2009.

7PerceptionofAsthma.Rubinfield,AR.Pain,MC,Lancet.1976Apr24;1(7965):882‐4.

8Acutebronchialasthma.Relationsbetweenclinicalandphysiologicmanifestations.McFaddenERJr,KiserR,DeGrootWJ.N

EnglJMed.1973Feb1;288(5):221‐5.

9Plaut,TF.OneMinuteAsthma:WhatYouNeedtoKnow.Amherst,MA.Pedipress;2008:32.

10Ibid.34.

11EPR‐2:ExpertPanelReport2:GuidelinesfortheDiagnosisandManagementofAsthma.1997.NIHPublicationNo.97‐4051.

p37.

12Plaut,TF.ChildrenwithAsthma:AManualforParents.Amherst,MA.Pedipress,1985.

13EPR‐3:ExpertPanelReport3:GuidelinesfortheDiagnosisandManagementofAsthma.2007,NIHPublicationNumber08‐

5846.Availableat:http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm.AccessedJuly27,2009.

14PlautTF.Thepeakflowdiary:Apowerfultoolforasthmamanagement,ContemporaryPediatrics,1993;10:61.

15Plaut,TF.ThePeakFlowDiary,AmericanJournalofAsthma&AllergyforPediatricians,1994;7:37‐39.

16Plaut,TF.AsthmaPeakFlowDiaryImprovesCare”(letter)AnnalsofAllergy,Asthma,&Immunology,1996;76:476‐8.

17Plaut,TF.ThePeakFlowDiary,AmericanJournalofAsthma&AllergyforPediatricians,1994;7:37‐39.

18Plaut,TF.ManagingAsthmaCare,AmericanJournalofManagedCare,1997;3:485‐490.

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19Plaut,TF.ASystemsApproachtoAsthmaCare,withHowellT,WalshS,PastorM,JonesT,ManagedCareQuarterly,1996;

4:6‐18.

20BiermanWC,PearlmanDS,ShapiroGG,BusseWW.Allergy,Asthma,andImmunologyfromInfancytoAdulthood.

Philadelphia,PA.WBSaunders;1996:277.

21Berkowitz,CarolD.Pediatrics:APrimaryCareApproach.Philadelphia,PA.WBSaunders;2000:270

22 Govias,G,MitchellI.AsthmaEducation:PrinciplesandPractices.Edmonton,Alberta.TheAsthmaEducationClinic;

2005:245.

23Plaut,TF.OneMinuteAsthma:WhatYouNeedtoKnow.Amherst,MA.Pedipress,Inc;2008:42.

24NationalInstituteofHealthPublication.EPR‐3:ExpertPanelReport3:GuidelinesfortheDiagnosisandManagementof

Asthma.2007:392.Availableat:http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.htm.AccessedJuly2,2009.

25Plaut,TF.OneMinuteAsthma:WhatYouNeedtoKnow.Amherst,MA.Pedipress,Inc;2008:30.

26ibid.42

27ibid.40