Author Index

Page numbers printed in italics refer to References

Abal, M. 215,220,224 Abela-Medici, A. 45 Abouabdellab, A. 211 Acuna, A.V. 215,220,224 Agius, L. 45 Ahem, D.O. 215 Ahn, Y-O. 208 Ahond, A. 149,204, 216, 222 Aizpurua, J.M. 206 Akhtar, M. 44 Alaimo, C.A. 217 Albrecht, P. 44 Alderfer, J.L. 220 Ali, S.M. 198-201, 204, 211 Altstadt, T.J. 203, 222 Amano, T. 222 Amat-Ouerri, E 146,215,220, 224 An, K.M. 223 Anderson, L.W. 212 Ando, A. 213 Ando, S. 201 Andreu, J.M. 146, 190,215, 219, 220, 224 Andruszkiewicz, R. 206 Angelucci, E 214 Angst, C. 50 Ankel-Fuchs, D. 49 Anraku, Y. 46 Anthony, EH. 223 Anziano, D.J. 212 Aoyagi, Y. 223 Aparicio, PJ. 47 Appendino, O. 58,63,71,72, 134, 154,

186, 194-196, 198, 203-206, 212, 216, 220, 223

Arai, H. 49 Arakawa, H. 210, 213 Arigoni, D. 17, 37,42, 45, 50, 51 Arlandini, E. 196 Armstrong, D.K. 194 Arnold, J.M. 213 Amott, D.M. 46

Atshaves, B.P. 50 Aube,l. 196, 198, 211 Aubert, E 219 Aucken, C.l. 48 Axelsen, P.H. 176, 221 Ayer, WA. 46 Azerad, R. 207

Babcock, O.T. 43 Badham, N.E 217 Bagnoli, L. 209 Baker, D.C. 49 Baker, E.W 43 Baker,l.K. 173,219 Baker, S.D. 223 Balachandran, S. 205 Balasubramanian, S.Y. 173, 220 Baidon, C. 49 Ballantine, J.A. 45 Ballini, R. 212 Baloglu, E. 194, 210, 224 Bane, S. 146,172,189,215,219,220,224 Banerjee, A. 209 Banik, B.K. 207 Barasoain, I. 215, 220, 224 Barboni, L. 205, 212, 222, 223 Bardeen, K. 47 Barret, 1. 45 Barron, D.M. 224 Barynin, Y. 45 Bastow, K.E 223 Bats, J.W 48, 51 Battersby, A.R. 21,27,29, 31, 32, 37,

42, 46, 48, 49, 51 Bauder, C. 44 Baumes, J. 200 Beaton, I.M. 46 Beaulieu, N. 51 Bechtel, M. 218 Beckmann, M. 48 Beckvermit, J. T. 212

228 Author Index

Begue, J.-P. 211, 220 Beidiger, RJ. 210 Beijnen, J .H. 212, 225 Belloro, E. 198, 203, 216 Benesi, A.J. 219 Benigni, D. 200 Berg, K. 44 Bergmann, K.H. 45 Bergquist, P.R. 44 Berman, J.W. 219 Bernacki, R.J. 195-197,201,210,211,

218, 220, 224 Besenval, M. 225 Betoeil, J.-e. 219 Beusker, P.H. 206, 222 Beutler, J.A. 220 Bezard, D. 199, 212 Bhakuni, R.S. 197 Bhalla, K. 219 Bhat, L. 202 Bhatia, S. 213 Bhattacharyya, S. 195 Bhushan, V. 207 Biasoli, G. 201, 214 Bible, K.e. 44 Bickelhaupt, F 46 Biediger, RJ. 204, 211, 217 Bisht, K.S. 194 Bisi, A. 221 Bissery, M.-e. 195, 197 Blackburn, B. 214 Blagosklonny, M.V. 218 Blanche, F 42, 50, 51 Blechert, S. 153, 197, 216 Block, M.H. 46, 48 Boatman, P.D. 204,217 Bocca, e. 221 Boesen, J.J.B. 212 Boge, T.e. 195, 199-202, 204, 205, 210,

212,215, 221 Bolikal, D. 214 Bollag, D.M. 220 Bollbuck, B. 221 Bombardelli, E. 195, 196, 198, 203, 205,

206, 212, 216, 223 Bondoc, L.L. 49 Bonini, C. 207 Bonner,l.A. 214 Bonnet-Delpon, D. 211 Bonnett, R. 42,43, 44, 46, 51

Borella, e.P. 201, 221 Bornmann, W.G. 217 Bose, A.K. 115, 207 Botta, M. 153,203,216, 221 Bouchard, H. 69, 197-199, 202, 203 Boullais, C. 214 Bounaud, P.-Y. 197,201,202,215,218 Bourzat, J.-D. 67, 197-199, 202, 203, 206,

211,212 Bowman, M.K. 47 Boyer, P.D. 43 Braamer, L. 197, 213 Bradley, M.O. 201, 223 Braun, P.D. 217 Bravo, J. 45 Bressi, J.e. 223 Bricard, L. 195, 204, 205 Brielmann, H.L. 51 Brieva, R. 207 Brigaud, T. 206 Brinen, L.S. 45 Brinkman, H.R. 197 Brunt, R.D. 46 Brzozowski, D. 209 Buchsbaum, D.J. 214 B uchschacher, P. 46 Buckleton, J.S. 44 Budde, e. 213 Buisson, D. 207 Bukin, V.N. 48 Burkhalter, R.S. 49 Burkhart, C.A. 219 Bushell, M.J. 51 Bushey, M.L. 208 Buytendorp, M. 44 Buzdar, A.U. 194 Bykhovsky, v.Y. 27, 37, 48

Cabon, O. 207 Cabri, W. 211 Cachau, R.E. 173, 220 Callot, HJ. 43, 44 Cambie, R.e. 16,44 Cameron, B. 42, 50 Caplan, FR. 47 Carboni, J. 204, 221 Carboni, 1.M. 219 Carcano, M. 210 Caron, G. 205, 216 Carroll, BJ. 224

Author Index 229

Carter, P. 214 Casazza, A.M. 202, 204, 213, 221 Castedo, L. 200, 216 Castillo, E. 208 Ceccarelli, W. 196, 203, 206 Cegelski, L. 220 Chadha, R. 217 Chai, K.-B. 198-200,204,210, 2Il Chakravarty, S. 195, 196, 211, 219, 220 Chan, W.H. 51 Chander, M.e. 197, 223 Chandrasekhar, S. 208 Chang, e.K 27,31,43,48 Chang, e.KJ. 47 Chapman, 1.D. 47 Chatterjee, A. 195 Chatterjee, S.K 224 Chaudhary, A.G. 78, 198-202, 204, 209,

215,219 Chen, K 223 Chen, S.-H. 61,79,80,88,91,97,98,101,

134,196-205, 210, 212, 213 Chen, S.-T. 214 Chen, Y. 218 Cheng, e.e. 221 Cheng, Q. lSI, 154,200,216,217,

222, 223 Cheng, X. 197 Cheong, e.-S. 201 Cherestes, A.D. 206, 216 Cheruvallath, Z.S. 195, 198, 205, 206,

210, 211 Chi, D.Y. 214 Chiaroni, A. 204, 216 Chiba, 1. 222 Chidester, e.G. 203, 206 Chirlian, L.E. 219 Chmurny, G.N. 212, 219, 220 Cho, G.Y. 223 Choe, Y.S. 214 Choi, 1.H. 208 Choi, K-M. 200 Choi, S.U. 210 Chordia, M.e. 215 Chordia, M.D. 78, 107, 195, 199, 200,

204, 205, 212, 215, 219 Chu, P. 221 Chu, 1.-1. 214 Chung, H.-T. 210 Chung, W.-K 218

Cicero, D.O. 220 Ciomei, M. 196, 201, 203, 214 Claiborne, e.p. 217 Clardy, 1. 45 Clark, D.S. 213 Clark, G.R. 44 Clarke, P.A. 197 Closs, G.L. 46 Clowers,l.S. 195, 211 Coates, R.M. 224 Coburn, e.A. 217 Coggon, P. 193 Colin, M. 195, 197 Collins, 1.M. 212 Colombo, A. 212 Colombo, M. 196 Colombo, T. 196 Combeau, e. 195, 197, 219 Combs, e.M. 205 Commen;:on, A. 77,92, 113, 131, 137,

197-199, 202, 203, 206, 209, 211, 212, 219

Conover, e.D. 214 Conway, S.P. 217 Cook-Blumberg, L. 43 Corelli, P. 153,203, 216 Cork, M.S. 48 Cornaz, P. 44 Cornett, B. 203, 224 Correa, A. 208 Couladouros, E.A. 200, 217 Coutterez, e. 211 Cravallee, e. 197 Cravotto, G. 195, 198, 203, 205, 206 Cresteil, T. 220 Crich,l.Z. 207 Crommentuyn, KM.L. 212 Crosswell, A.R. 202, 213 Croteau, R. 194, 195, 224 Crouzet, 1. 42, 50 Crull, G. 200 Crumbliss, A.L. 50 Cryczynski, Z. 220 Curini, M. 211 Czaplinski, K-H.A. 221

Daigneault, L. 225 D' Aloisio, S. 225 D' Ambrosio, M. 43 Damen, E.W.P. 197, 213, 224

230 Author Index

D' Anello, M. 203 Danieli, B. 154,198,203,216 Daniewski, A. 51 Danishefsky, S.J. 161, 163, 217, 220 Darbie, L.G. 197 Da Re, P. 221 Das, B. 194 Das, R. 194 Dasgupta, D. 215 Datta, A. 197-200,203,204,211,222,223 Datta, D. 198 Dauter, Z. 45 Davidson, B.S. 221 Davidson, M.W. 218 Day, B.W. 178,220, 221 Debitus, C. 43 De Bont, D.B.A. 214 Debussche, L. 42, 50, 51 Deeg, R. 45 De Forges, B.R 43 De Groot, A. 206 De Groot, EM.H. 214, 216, 224 Deisenhofer, J. 44 De Koning, T.E 203 Delaloge, E 212 De Mattei, J.A. 223 Deng, L. 207 Denis, J.-N. 60, 195, 197, 207-209, 211 Deprez, D. 199 Desai, N.P. 211 De Suzzoni, S. 214 Deutsch, H.M. 213 Devanesan, P. 223 De Vos, D. 213 Dextraze, P. 202 Diaz, J.E 219 Dickerson, RE. 43 Di Cosmo, E 215 Didier, E. 197, 209 Dieden, RA. 219 Diekert, G. 49, 50 Di Grandi, MJ. 217 Dillon, J. 200 Dillon, J.L. 222 D'Incalci, M. 196, 212 Di Nello, R.K. 43 Ding, A. 219 Dischino, D.D. 213 Dobrowolski, PJ. 195, 196, 203, 206 Dolphin, D. 42, 44

Donati, M.B. 196 Dondoni, A. 122, 209 Donehower, R.C. 194, 212, 223 Donghi, M. 210 Dordick, J.S. 213 Dorman, G. 215 Doubek, D.L. 44 Douglas, RH. 44 Douglass III, J.G. 223 Downing, K.H. 170,218, 221, 224 Doyle, T.W. 196, 199, 202, 204, 205, 213 Dubois, J. 173,195,204,205, 212, 215,

219, 222 Dubs, P. 47 Duclos, O. 195,200, 207, 210, 215 Dulai, K.S. 44 Dupont, C. 221 Dutler, H. 46 Dutta, D. 222 Dutton, CJ. 46

Edsall, J.R. 215 Eisenhauer, E. 225 El-Deiry, W.S. 218 Ellefson, W.L. 50 Elsohly, H.N. 195 Engelborghs, Y. 219 Emiu, R. 195, 198, 203 Erhardt, P.W. 223 Erickson, J.W. 220 Eschenmoser, A. 16,21,25,29,33,35,37,

42, 44, 47, 49-51 Etoh, H. 45 Ettinger, D.S. 194 Evangelio, J.A. 215, 220

Fagemess, P.E. 50 Faigle, G. 200 Fairchild, C. 196-199, 210, 211, 213, 222 Fairchild, c.A. 203-205, 212 Fairchild, C.R 199, 200, 202, 204, 221 Fajer, J. 50 Falborg, L. 199, 204 Falk, H. 44 Falzone, c.J. 173, 219 Fan, W. 218 Fanelli, R 212 Fang, K. 215 Fang, Q.-c. 196, 197, 202, 222 Fang, W.-S. 87, 196, 197, 202, 222

Author Index 231

Fant, J. 194 Farber, G. 49 Farina, V. 102, 113, 196-206, 211, 213 Farooq, S. 49 Fassler, A. 49, 50 Fattori, D. 216 Feicht, A. 207 Fenical, W. 221 Fenning, M.e. 47 Fenoglio, I. 102, 195, 196, 204, 206 Ferlini, e. 197 Ferran, J.M. 45 Ferrer, J.e. 45 Ferrito, V. 45 Fisher, B. 225 Fita, I. 45 Fkyerat, A. 211 Floreancig, P.E. 217 Floss, H.G. 194, 224 Fluks, L. 216 Fojo, T. 218, 221 Folkers, K. 50 Fontana, E. 214 Fookes, e.J.R. 43, 46 Forand, D. 225 Ford, S. 45 Forman, A.D. 194 Fouque, E. 209 Franc!, M.M. 219 Franco, S. 208 Franklin, J.C. 213 Franzoi, L. 196 Frechard-Ortuno, I. 218 Friedman, H.C. 50 Friedrich, W. 42 Fromme, P. 44 Frye, D.K. 194 Fuero-Oderda, e. 219 Fuji, K. 153,216 Fujisawa, T. 114, 207 Fukunishi, K. 43 Furenlid, L.R. 50 Furu, E. 208 Fusar-Bassini, D. 196, 201, 203, 206, 216

Gabetti, B. 196, 205 Gabriel, L. 221 Gadoni, E. 221 Gaedicke, G. 223 Gaillard, e. 212

Gallagher, D. 207 Gao, Q. 198, 200, 203, 205, 211, 222 Garcia-Arenas, R. 201, 223 Gariboldi, P. 196, 205 Garrett, R.H. 47 Gebhard, I. 195, 196, 203 Gelmon, K.A. 225 Geng, C. 207 Geng, X. 201, 221, 224 Genier, L. 225 Gennari, C. 127,210 Gentile, G. 216 Gentile, L.N. 204, 217 Georg, G.I. 57,58,61,66,69,71,72,78,

84, 97, 98, 107, liS, 126, 129-133, 137, 144-146, 170, 172, 173, 177, 184, 195-207,210-212, 215, 218, 220-223

Gerlach, B. 43 Gest, H. 47 Gharpure, M.M. 195, 199, 200, 203, 212 Giannakakou, P. 177, 178,199,218,

220, 221 Giavazzi, R. 196 Gibson, ES. 222 Gilbert, e.w. 214 Gilles, H.H. 49 Gillet, B. 219 Gimbert, Y. 211 Gimi, R.H. 196, 211 Giribone, D. 214 Glasenapp-Breiling, M. 43 Glass, T.E. 217, 224 Glinski, J.A. 213 Goeldner, M. 219 Goetz, M. 220 Golberg, J.L. 47 Golding, B.T. 42 Golik, J. 198, 200, 202, 205, 213 Gonda, A. 221 Goodman, J. 222 Gordon, M.A. 221 Gorodetsky, R. 220 Giitschi, E. 47 Graf, H. 216 Grampovnik, D.J. 199, 201, 203, 205 Granicher, C. 217 Gray, H.B. 43 Grebenko, A.I. 45 Greene, A.E. 60, 116, 120, 127, 134,

195, 197, 207-209, 211

232 Author Index

Greenwald, R.B. 140,214 Grgurina, I. 46 Griffiths, WT. 46 Grover, S. 199, 201, 202, 215 Grumbine, F.e. 194 Grunewald, G.L. 195. 205, 220, 221 Gu, R.L. 209 Guedira, N. 219 Guenard, D. 146, 195, 197, 201. 204,

205, 210, 215, 219, 221, 222 Gueritte, F. 195, 204, 205, 221, 222 Gueritte-Voegelein, F. 195, 197,201,

204.205,210,215,219 Guerriero, A. 43 Guilard, R. 44 Gunasekera, S.P. 220 Gunatilaka, A.A.L. 103, 104, 199. 205,

209, 212 Gunn, e.W 205, 220 Guo,l.-Y. 216 Guo, Z. 221 Gussio, R. 220, 221 Guy, R.K. 199, 200, 215, 217, 220

Ha, H.-I. 208 Habus, I. 206 Hadd, H. 198 Hader, D.P. 44 Hadi, H.A. 221 Haines, K. 200 Haisma, H.J. 214 Hakimelahi, G.H. 213 Ham, W-H. 209 Hamajima, Y. 216 Hamamoto, H. 223 Hamel, E. 199, 201-205, 215, 220 Hamilton, e.L. 49 Hammink,l.B. 216 Han, F. 195 Han, Y. 215,219 Hanaoka, M. 208 Hannah,l. 46 Hansel, S.B. 202, 222 Hara, K.-l. 210, 222 Hara, K.-Z. 210, 222 Hara, R. 217 Harada, N. 210, 213 Harmon, P.A. 213

Harriman, G.e.B. 195, 198, 200, 202, 206, 207,210,211, 215

Harris,l.W. 212 Harrison, P.l. 46 Harusawa, S. 217 Hasegawa, M. 208, 217. 218 Hashimoto, M. 215. 219 Hashiyama, T. 210, 213 Hassner, A. 217 Hatano, M. 45 Hattori, K. 208 Hauck, F.P. 46 Hauck, S. 202 Hauck, S.l. 51, 206 Haugwitz, R.D. 213 Haukaas, M.H. 208 Hayashi, M. 210 Hayashi, N. 223 He, L. 219-221, 223 Hebbler, A. 49 Heerding,l.M. 211. 215, 219 Heinrich, H.e. 51 Hemamalini, S. 223 Henderson, G.B. 46 Henry, R.F. 203, 205 Hensens, O. 220 Hepperle, M. 195, 197, 200, 205, 206,

210-212,215,218 Hernandez, A.H. 221 Hernandez, M. 213 Hertle, R 51 Heys, J.R 214 Hezari, M. 194 Higgs, P.l. 199, 218 Hill, e. 219 Hill, S.E. 205 Hilton, B.D. 173, 219, 220 Himes, RH. 172, 198-202, 204, 205, 207,

210-213, 215, 221-223 Hirai, Y. 218 Hirofumi, T. 69, 198 Hirota, Y. 201, 211 Hiyama, T. 197 Hoch,l. 224 Hodgkin, D.e. 50 Hoemann, M.Z. 196, 211 Holliger, e. 50 Holmes, F.A. 194 Holton, R.A. 71, 77, 97, 114, 126, 130,

131, 157, 158, 163,197-200, 204, 207,210, 211, 217, 218

Hoornaert, G. 44

Author Index 233

Hooser, S.B. 222 Hoper, E 43 Horiguchi, T 200, 216, 217, 222, 223 Horiguchi, Y. 216, 218 Hortobagyi, G.N. 194, 222 Horwitz, S.B. 56,144,170,178,

194,201-203, 209, 211, 215, 218-221, 223

Hosoyama, H. 206 Houze, J.B. 217 Howell, J.M. 209 Huang, C.-M. 141,214 Huang, N. 221 Huang, Q. 224 Huang, S. 198-200, 202-205, 211,

212,222 Huinink, WWTB. 225 Huizing, M.T. 212 Hunt, D.M. 44 Hunt, J .E. 47 Hunter, N.R 214, 218 Hwang, c.-K. 217 Hwang, D. 221 Hwu, J.R 140,213 Hynninen, P.H. 44, 47

Idmoumaz, H. 211 Igarashi, Y. 49 Ihshikawa, H. 44 Iida, K. 50 Iimura, S. 198, 211, 222 Imfeld, M. 45, 50, 51 Ina, K. 45 Innertsberger, C. 208 Inoue, T 214, 220, 221 Isaacs, R.C.A 217 Isenring, H.P. 44 Ishibuchi, S. 209 Ishida, T 207 Ishikawa, H. 45 Ishimoto, M. 48 Ishitani, H. 208 Ishiyama, T 204, 211 Ishizuka, T 209 Ito, S. 46 Itokawa, H. 221 lvey, C.A 195, 201, 212 Iwadare, H. 208, 218 Iwahana, M. 222 lwatani, W. 222

Jaccarini, V. 45 Jacobi, P.A. 42,51 Jacobsen, E.N. 117, 207 Jaenchen, R 49 Jagtap, P.G. 199,200, 204, 212, 215,

220,221 Jain, R 194 Jain, RP. 223 Jakupovic, J. 195, 198, 203, 206, 216 Jakupovic, S. 216 Jalluri, RK. 195 Janes, R.W. 218 Janichen, J. 217 Janoff, AS. 213 Jansen, J.M. 220, 221 Jansen, R 216 Jaun, B. 33, 49 Jayasinghe, L.R. 196, 199, 203, 204, 211 Jeffry, S. 43 Jensen, P.R. 221 Jha, A. 194 Jiang, Y.Q. 199, 203, 204 Jimbo, T 222 Jimenez-Barbero, J. 173, 220 Jin, Q. 224 Jitrangsri, C. 195, 196 Johansen, J .E. 50 Johnson, J. 197 Johnson, K. 203 Johnson, M.K. 49 Johnson, RA. 66, 91, 195, 196, 203, 206 Johnson, TD. 222 Johnston, K.A 197, 199, 200, 202-205,

210,222 Jolik, J. 205 Jones, C. 51 Jones, K. 48, 49 Jordan, P. 44 Jordan, P.M. 43 lost, S. 211 Jun, S.-J. 200 Jung, D.-I. 200 Jung, D.K. 217 Juo, R.R. 217

Kadish, M.K. 44 Kadow, J.E 197, 199, 202-204,

210-212, 222 Kajiro, H. 197 Kajiwara, M. 51

234 Author Index

Kameo, K. 200 Kamin, H. 47 Kanazawa, A.M. 208, 209 Kant, J. 67, 133, 134,197, 198, 201,

202, 206, 211, 214 Kantoci, D. 44 Kar, A.K. 217 Karuso, P. 44 Karvinen, E.K. 207 Kashima, H. 217 Katki, A 212 Katz, J.J. 47 Kawahara, S. 217 Kawasaki, S. 49 Kayser, M.M. 207, 209 Kazuya, K. 216 Keams, J. 207, 209 Keefer, CJ. 218 Keller, W 49 Kelly, R.C. 66, 129, 195, 196, 203,

206,210 Kepler, J.A. 142, 214 Kerns, E.H. 213 Khazaeli, M.B. 214 Khmelnitsky, YL. 213 Khuong-Huu, F. 81, 198, 200 Kim, B.-T. 214 Kim, D. 210, 214 Kim, E.E. 214 Kim, H.-B. 204, 217 Kim, H.-K. 200. 223 Kim, I. 208 Kim, K.-c. 197 Kim, M.-J. 125, 197, 206, 209 Kim, S. 199, 204, 210, 217 Kim, S.-c. 97, 99, 199-201, 204, 223 Kim, Y 221 Kim, Y.-H. 209 Kingston, D.O.1. 78, 79, 82, 97, 103, 107,

145, 146, 172, 177, 178,194-196, 198-205,209,210,212,213,215, 218-224

Kirikae, F. 218, 219 Kirikae, T. 218, 219 Kishi, K. 218 Kishi, Y 25, 43, 47 Kishore, V. 44 Kita, K. 46 Kitamoto, M. 223 Klar, U. 216

Klein, A. 50 Klein, L.L. 73, 83, 199, 201. 203, 205 Kleine-Klausing, A 216 Klis, WA 223 Klukas, O. 44 Knaff, D.B. 47 Knipe, J.O. 202, 213 Ko, S.Y 223 Kobayashi, J. 206 Kobayashi, R. 213 Kobayashi, S. 208 Kobelt, A. 49 Kodama, T. 49 Koerner, H. 49 Kohno, M. 153,216 Kojo, S. 43 Kolm, R.H. 45 Konishi, K. 46 Koopman, FJ. 225 Koskinen, AM.P. 207 Kouichi, U. 198 Koupal, L. 220 Kowalski, RJ. 220 Kramer, R.A 202 Kratky, C. 49-51 KrauB, N. 44 Krauss, N.E. 209,211,215,217,219 Kriiutler, B. 42, 49-51 Kriemler, H.P. 45, 50 Krone, U.E. 50 Kudo, T. 222 Kuduk, S.D. 195-197, 201, 202, 207,

210, 211, 218, 220 Kumar, A 194 Kunieda, T. 122,209 Kuroda, A 210 Kusama, H. 216-218 Kusch, D. 43, 48 Kuwajima, I. 165, 171,216-218

Lai, Y-K. 147,213,214 Lakdawala, A. 224 Lal, T.K. 203 Lamba, D. 216 Lambertucci, C. 205, 212, 223 Langemann, A. 46 Langley, D.R. 211 Larcheveque, M. 207 Larsen, L.K. 43, 47 Lartey, P.A. 199

Author Index 235

Lataste, H. 201 Latreille, 1. 225 Laufer, K 50 Lavelle, F. 195, 197, 200, 201, 210, 211 Lazarides, E. 220 Leach, S.D. 218 Leanna, M.R 223 Lebecq, A. 225 Lederer, E. 17,45 Lee, A. 214 Lee, C.O. 210 Lee, D. 125, 197, 203, 206, 209, 217 Lee, F.L. 222 Lee, F.-Y. 188,202,223 Lee, G.S. 208 Lee, J.P. 47 Lee, K.-H. 223 Lee, K.-S. 200, 210 Lee, K-Y. 209 Lee, S. 223 Lee, S.-G. 115, 207, 208 Lee, S.-H. 209 Lee, S.w. 207 Lee, W.-K 207 Lee, Y.-S. 209 Leenders, RG.G. 214 Leeper, F.J. 42, 46, 48 Le Gall, J. 47 Le Goff, E. 46 Le Goff, M. 204 Le Goff, M.-T. 201, 215 Leimgruber, W. 46 Lemberg, R 45 Lenger, S.R 224 Lerro, KA. 215 Lesser, G.J. 212 Lever, A.B.P. 43 Lewis, N.G. 51 Lewis, N.J. 51 Li, C. 140, 214 Li, D. 224 Li, G. 208 Li, KM. 44 Li, L. 199, 201, 203, 205 Li, W. 223 Li, Y. 215, 220 Liang, F. 200, 204, 217 Liang, J. 200, 213 Liang, X. 197, 202, 203 Liang, X.-T. 196, 197, 202, 216, 222

Liesch, J. 220 Lieu, C.-H. 213 Lillo, M.P. 215 Lin, C.M. 199, 202, 205, 220 Lin, D.-L. 216 Lin, H.-Y. 200 Lin, S. 195-197, 201, 206, 207, 210, 215,

219-221, 224 Lincke, A. 45, 48 Lindel, T. 221 Link, J.T. 217 Liotta, D.C. 203, 221 List, B. 51 Liu, I.H. 204, 207, 217 Liu, J.-J. 217 Liu, R-S. 214 Liu, R.-W. 216 Liu, Y. 201, 202, 215, 218, 219 Liu, Z.-Y. 205 Livingston, D.A. 49 Lode, H.N. 223 Loewen, P. 45 Loewen, P.C. 45 Lohray, B.B. 207 Lombardi Borgia, A. 214 Long, B.H. 196, 197, 199, 200, 202-205,

210-213, 221, 222 Longley, RE. 220 Lopes, N.M. 203 Lowenthal, RE. 217 Luche, M.-J. 207, 208 Lund, M. 205 Lwowski, W. 46

Ma, L. 44 Ma, Z. 218 Mackenzie, N.E. 50 Mackman, RL. 48 Magee, T.V. 217 Magri, N.F. 195, 196, 201, 202, 223 Mai, G. 48 Maj, M. 45 Makowski, L. 218 Malak, A.G. 219 Malkin, R 47 Mamber, S.w. 198, 199, 201, 202, 204,

213 Mamedov, V.A. 223 Marner, O. 205, 206, 216, 223 Mandai, T. 180,210, 222

236 Author Index

Mandjes, I.A.M. 225 Manfredi, JJ. 218 Mangatal, L. 197, 201 Manhas, M.S. 207 Mantellier, P. 211 Marcotullio, M.e. 211 Marder, R. 195, 205 Marder-Karsenti, R. 103, 204 Margraff, R. 199 Maring, CJ. 199, 201, 203, 205 Marini, F 209 Marquess, D.G. 217 Marshall, D.R. 201, 203 Martinez, A. 214 Mascarenas, J.L. 200, 216 Mason, KA. 218 Mastalerz, H. 182,222 Masters, JJ. 217 Mathew, A.E. 201,213 Matiskella, J.D. 202, 213 Matovic, R. 150,216 Mattern, SJ. 203 Matthews, J.e. 49 Mayhew, E. 213 Mays, D. 218 Maziere, J.e. 47 McChesney, J.D. 116,195, 197, 207 McDonald, E. 48 McGovren, J.P. 203 McGrane, P.L. 217 McGuire, WP. 194 McLachlan, KL. 50 McNamee, C.G. 209 McPhail, AT. 193 McQueney, P.A. 220 Mejillano, M.R. 199, 201, 205, 213 Melik-Adamyan, W 45 Mellado, W 201, 223 Meng, W 217 Menichincheri, M. 61, 196, 201, 203, 206 Merchan, FL. 208 Merckle, L. 204, 222 Merino, P. 208 Metaferia, B.B. 224 Michaelis, M.L. 218 Michalski, TJ. 47 Michaud, E. 197 Michaud, L.B. 222 Micklefield, J. 48 Middleton, M.L. 209

Mielgo, A. 206 Miglietta, A. 221 Mihovilovic, M.D. 207 Mikkilineni, A.B. 202, 213 Mikuni, K 210, 222 Milanesio, M. 173, 220 Milas, L. 214, 218 Miller, M.L. 201,221 Milligan, R.A. 218 Milross, e.G. 218 Min, e. 51 Minehan, T.G. 43, 47 Minoia, e. 212 Mioskowski, e. 219 Miranda, J.I. 206 Mitamura, S. 197 Mitscher, L.A 198. 205, 211, 220 Mitsui, I. 196, 198, 201, 21/ Miyata, M. 208 Mizsak, SA 206 Moan, J. 44 Mocek, U. 194 Mohapatra, S. 208 Molinero, A.A. 194, 195, 201, 212 Moll, J. 49 Mombelli, L. 51 Monardo, e. 196 Monegier, B. 212 Mong, Y. 216 Mongelli, N. 196, 201, 203, 206, 210, 214 Monsarrat. B. 212, 220 Montforts, FP. 21, 31, 43, 45, 46, 48, 49 Mooberry, S.L. 221 Moon, M.-S. 200, 201 Moore, R.E. 43, 47 Morazzoni, P. 196 Mori, A 197 Morihira, K 216-218 Morita, H. 221 Morliere, P. 47 Morooka, K. 209 Morris, H.R. 48 Morton, H.E. 223 Mourabit, A.A. 204, 216 Moyna, G. 220 Mucciaro, T.P. 217 Muhlebach, M. 217 Mukai, e. 208 Mukaiyama, T. 121,167,208,217,218 Mulders, S.J.E. 216

Milller, CM. 45 Milller, G. 17, 37,45, 50, 51 Milller, P.M. 49 Muller, R. 205 Mullineaux, CW. 44 Mullins, S. 214 Mulzer, J. 42,51 Murphy, MJ. 47 Murray, C.K. 195, 197, 212 Murray-Rust, P. 45 Murshudov, G.N. 45 Murthi, K.K. 204, 217 Muschik, G.M. 219, 220

Nadizadeh, H. 204, 210, 211, 217 Nagura, M. 222 Nakada, M. 217 Nakamura, K. 209, 222 Nakamura, N. 217 Nakanishi, K. 210, 215, 222 Nakanishi, N. 213 Nakano, M. 218, 219 Nakata, T. 213 Nakayama, K. 198 Nandanan, E. 208 Nanduri, Y. 209 Nano, G.M. 204 Nantermet, P.G. 199, 200, 217 Narayanan, y.L. 213 Natchus, M.G. 217 Nath, J.P. 201, 213 Nathan, CF. 219 Neckers, L. 218 Nedea, M.E. 205 Neidigh, K.A. 196, 203 Neier, R. 43 Nettles, J.H. 203, 224 Nevalainen, TJ. 224 Nevins, N. 220 Newton, L.K. 194 Nicholls, P. 45 Nicholov, R. 215 Nichols, P.J. 223

Author Index

Nishimura, K. 208 Nishimura, T. 208 Noel, J.P. 214 Nogales, E. 218, 221, 224 Nooijen, w.J. 212 Norris, J.R. 44, 47 Northuis, J.M. 209 Nozawa, T. 45 Nuruzzaman, M. 216 Nussbaumer, C 51 Nussberger, R. 51

Obinger, C 45 Ocampo, R. 43, 44 Oda, K. 213 O'Doherty, G.A. 208 Odriozola, J.M. 206 Ofner, S. 49 Oh, CR. 208 Oh, S.-J. 214 Ohashi, M. 213 Ohkawa, N. 208 Ohmori, H. 213 Ohsuki, S. 198, 211, 222 Ohtsubo, T. 216

237

Ojima,l. 57,62-64,67,68,78,83,84, 113, lIS, 116, 126, 130-132, 134, 144, 171,173,176,178,191,195-197, 200-202, 206, 207, 210-212, 215, 218-221, 224

O'Keeffe, W.S. 197 Okumoto, H. 210, 222 Olsen, C.E. 194 Orii, Y. 45 Oritani, T. 185,200,216, 217, 222, 223 Orr, G.A. 201,202,215,219,221,223 Oruganti, R.S. 197 Oshitari, T. 222 Ouellet, C 202 Ourevitch, M. 2ll, 220 Ozaki, K. 210, 213 Ozaki, S.l. 50, 51

Nicolaou, K.C 77,78, 147, 157, 158, 163, Pace, P. 196 199, 200, 215, 217, 220, 221

Nicoletti, M.l. 196 Nidy, E.G. 195, 196, 203, 206 Niethammer, A. 223 Nikolakakis, A. 205, 206, 216, 223 Nishimori, T. 216-218

Pae, H.-O. 210 Pais, M. 221 Palmedo, G. 49 Palmer, S.E. 43 Paloma, L.G. 173, 220 Palomo, C 114,206

238 Author Index

Pan, J.-w. 200 Park, G.-S. 208 Park, H. 180,195, 199, 206,207,

210-212, 215, 222 Park, M.-S. 209 Park, YH. 195, 196, 206, 207, 214 Pannar, Y.S. 194 Partridge, J.e. 44 Patel, H.Y. 213 Patel, P. 224 Patel, R.N. 124, 209 Patterson, G.M.L. 43, 47 Paukstelis, J. Y. 212 Paulsen, H. 217 Paulvannan, K 217 Payn~, C. 204 Peck jr., H.D. 47 Pecquet, P. 197 Pelter, A. 17, 45 Pendri, A. 214 Pera, P. 195-197, 201, 211, 220, 224 Perez-Ramirez, B. 215 Perrone, D. 209 Perrone, RK 202 Pesenti, E. 203, 214 Peters, L.J. 218 Peterson, J.R. 207 Pettit, G.R 44 Pfaltz, A. 33, 49-51 Pfenniger, A. 5] Phukan, P. 208 Piccariello, T. ] 95 Pichon, C. 51 Picot, E 197 Pietenpol, J.A. 218 Pietra, E 43 Pinciroli, Y. 196, 203, 206 Piotrowska, D.G. 209 Piszczek, G. 220 Pitts, T.w. 203 Place, E. 205, 222 Plaquevent, I.e. 50 Plattner, J.J. ]99, 20], 203, 205 Plubrukarn, A. 221 Poliks, B. 220 Poliks, M. 220 Pollina, E. 207 Porra, R.I. 47 Potier, P. 58, 59, 195, 197, 201, 204, 205,

210, 216, 219, 222

Poujol, H. 216 Poupat, e. 103, 149,204, 216, 222 Poy, G. 221 Prestwich, G.D. 215 Priest, D.G. 219 Prinsep, M.R 43, 47 Procter, D.I. 197 Psaila, A.E 45 Pulicani, J.-P. 198, 199, 202, 203 Puustinen, A. 43 Py, S. 198, 200

Qu, C. 207 Qualls, S.I. 195, 196, 203, 206

Raatz, D. 208 Raber, M.N. 194 Rafaiani, G. 205 Ragan, R. 218 Raisch, KP. 214 Ramdayal, ED. 205 Rampa, A. 221 Ranciat, N. 2] 8 Rao, C.S. 214 Rao, K.Y. 67,68,197, 215 Rao, S. 203, 215, 219 Rao, S.P. 194 Rasetti, Y. 49, 5] Rasmussen, M.W. 223 Rawlins, D.B. 217 Reddy, S.H.K. 223 Reibig, H.-U. 208 Reiser, O. 208 Reiter, L.A. 46 Remy,E. 50 Renaud, J. 200, 217 Rengan, K 210, 211 Renner, M.W. 50 Ribes, O. 43 Riche, e. 204, 216 Rickard, e.E.E 44 Riether, D. 51 Righi, G. 207 Rimoldi, J.M. 194, 195, 199, 201-203,

212,215 Rinehart, KL. 44 Ringel,1. 209, 211, 215, 219, 220 Riou, J.E 197 Riou, J.G. 195 Rithner, e.D. 224

Author Index 239

Riva, A. 196 Robinson, J.A. 48 Rocchetti, M. 225 Rodi, D.J. 218 Rodrigues, M.L. 141,214 Rodriguez, I. 214 Roers, R. 223 Roessner, e.A. 48, 50, 51, 224 Roh, E.J. 207, 208, 210, 214 Rohr, B. 216 Rohy, J. 194 Romanowski, F. 48 Rosati, O. 211 Rose, We. 202, 204, 205, 210, 212,

213, 222 Rosenkranz, H.S. 220 Rosenshein, N.B. 194 Rosing, H. 225 Rossi, C. 196 Roth, G.P. 201, 203 Roth, M. 47 Rourick, R. 200 Rousseau, B. 219 Rouz, D. 221 Rowinsky, E.K. 194, 212 Royer, I. 212 Rudiger, W 46 Rumboldt, G. 207 Runge, TA. 206 Rutter, J. 207

Sable, S. 212 Sackett, D. 221 Sackett, D.L. 205,215 Saenger, W. 44 Safavy, A. 141,214 Saicic, R.N. 150, 216 Saitoh, K. 208, 217, 218 Saitoh, M. 208 Sakai, R. 44 Sakata, K. 45 Sakoh, H. 208, 217, 218 Samala, L. 199 Samaranayake, G. 195, 196, 201, 202,

215 Sambaiah, T 213 Sanchez, E. 219 Sanderink, G.J. 212 Sandford, P.A. 211 Sanganee, H.J. 218

Santander, P.J. 42, 50, 51 Santi, e. 209 Santus, R. 47 Sarragiotto, M.H. 205 Sarver, J.G. 223 Satkofsky, J. 2 J 7 Sauer, J. 46 Sauer, J.-M. 222 Sauriol, F. 205, 206, 216, 223 Savidis, L. 50 Scambia, G. 197, 203 Scatena, C.D. 218 Schade, W 208 Schaefer, J. 220 Scheer, H. 42, 43 Scheeren, H.W. 141, 142, 148, 150, 151,

188, 197, 206, 213, 214, 216, 222, 224 Schellens, J.H.M. 212, 225 Schembri, P.J. 45 Schenk, O. 216 Schiff, P.B. 194 Schimming, R 218 Schmiedl, J. 50 Schneider, E. 50 Schoch, S. 46 Schoendorf, A. 224 Schot, M. 225 Schraa, G. 50 Schreiber, J. 49, 50 Schroeder, D.R. 214 Schulz, G. 43 Schulz, H. 216 Schulze, G.E. 202 Schwartz, U.M. 46 Schwartz, W.S. 211 Scott, A.I. 37,42, 43, 48, 50, 51, 219,

220,224 Scott, RA. 49 Scott, Z.A. 215 Sedlmeier, R 50 Seely, G.R. 42 Seither, P. 49 Seki, Y. 48 Sekiguchi, Y. 200 Seligson, A.L. 223 Semola, T 209 Sengupta, S. 215 Senilh, V. 195, 197, 201 Serra, A.A. 207 Sessler, J.L. 44

240 Author Index

Sevenet, T. 221 Sharpless, K.B. 208 Shashoua, VE. 201 Shen, H.-J. 221 Shen, y-e. 200 Sheng, z.e. 46 Shi, Q. 223 Shibayama, K. 217 Shigemori, H. 206 Shiina,1. 208,217, 218 Shimada, H. 45 Shimizu, M. 207 Shimizu, T. 213 Shindo, M. 204, 217 Shu, AYL. 214 Shuker, A.J. 217 Shultis, K. 200 Siegel, L.M. 27,47 Sih, C.J. 115, 207 Siirila, J.P. 207 Simonot, B. 215 Singh, C. 219 Singh, S.K. 194 Sings, H.L. 44 Sisti, N.J. 197 Skyring, G.w. 47 Slater, J.C. 196, 197, 210, 211, 218, 220 Sloboda, R.D. 215 Smith, e.e. 204, 217 Smith, e.D. 43, 47 Smith, K.M. 42, 44, 50 Smith, U. 47 Snow, R.J. 46 Snyder, J.P. 96, 105, 173, 178, 203,

220-224 Snyder, L.B. 217 Soga, T. 65, 84, 100, 180, 196, 198, 199,

201, 204, 211, 222 Sogawa, N. 48 Somoza, e. 198, 200, 204, 217 Song, e.E. 130, 207, 208, 210, 214 Soong, Y.-K. 218 Soon-Shiong, P. 211 Sorensen, E.J. 217, 221 Sotiriou, e. 47, 48 Soto, J. 200, 216 Sottani, C. 212 Souto, A.A. 215,219,220, 224 Sovak, M. 223 Sparreboom, A. 212

Spencer, J.B. 48, 51 Sperling, D. 213 Spinner, e. 49 Srivastava, R.P. 207 Starns, A.J.M. 50 Standridge, R.T. 214 Stella, VJ. 201, 213 Stevens, R. V 42, 51 Stewart, J.D. 207 Stewart, Z.A. 218 Stobbe, e.e. 47 Stoll, A. 42 Stoller, M.L. 47 Stolowich, N.J. 48, 50, 51 Stolzenberg, AM. 45 Straubinger, R.M. 220 Strauss, S.H. 45 Strobe, R. 219 Studelska, D.R. 220 Stupperich, E. 50 Stura, S. 196 Sudalai, A 208 Suffness, M. 138, 193,194, 213 Sullins, D.W. 44 Sun, e.-M. 195, 196, 206, 207, 210, 211 Sun, D.-A 223 Sutton, J.e. 217 Suzuki, Y 204, 2lJ, 217 Swigor, J.E. 214 Swindell, e.S. 124, 131, 143, 201, 209,

211,215,219, 220, 223 Switala, J. 45 Szarka, L.J. 209

Tachibana, Y 223 Tali, A. 203 Takatori, K. 51 Takeda, T. 51 Takenoshita, H. 201, 204, 211 Takeuchi, e.S. 196, 201, 218 Takeya, K. 221 Tallent, C.R. 214 Taneja, P. 194 Tang, L.J. 218 Tang, S. 200, 204, 217 Tani, Y-1. 208, 217, 218 Tao, e. 204, 211, 217 Tao, M. 209 Tauber, A 44 Taylor, G.F. 214

Author Index 241

Taylor, H.L. 193 Taylor, P.v. 48 Taylor, RE. 217 Tchertanov, L. 221 Tejero, T. 208 Temperini, A. 209 Tepper, M.A. 2 J 9 Terasawa, H. 196, 198, 199, 201, 204,

211, 222 Ter Haar, E. 57, 195, 220 Terry, RC. 223 Terwogt, J.M.M. 225 Testaferri, L. 209 Thauer, RK. 33, 49, 50 Thayer, A.M. 194 Theriault, RL. J 94 Thibaut, D. 37, 42, 50, 51 Thoison, O. 221 Thomas, S.A. 199, 201, 203, 205 Thompson, M. 48 Thoret, S. 205, 221, 222 Thornton, S.S. 214 Thottathil, J.K. 209 Tiecco, M. 209 Tien, G. 221 Tietze, L.F. 43 Timkovich, R 27,43, 48, 49 Tokiwa, S. 51 Tolcher, A. 225 Tiillner, E. 48 Tollon, Y. 215 Tommoka, K. 217 Torregiani, E. 205 Tove, S.R 47 Townsend, C.A. 50 Toy, A. 206 Tsay, S.-C. 213 Tsuboi, S. 223 Tsuchiya, Y. 222 Tsujihara, K. 213 Tsukamato, I. 43 Tsunehiko, N.K. 199 Tsunehiko, S. 198 Tsuruo, T. 216, 218 Tucker, B.E. 44 Turner, S.P.D. 46 Tynebor, R 207

Veda, Y. 202, 213 Veno, H. 199, 217

Veno, M. 119,208 Vgliengo, P. 220 Voto, K. 133, 196, 198, 201, 204,

211,222 Vsyatinsky, A. 213

Vainshtein, B.K. 45 Valenta, Z. 46 Valenti, P. 221 Valero, V. 222 Van Beek, T.A. 206 Van Berkom, L.W.A. 214 Vandais, A. 214 Van den Berg, J.D. 212 Van den Bergh, P. 44 Van den Bergh, TJ.M. 224 Van den Bossche, B.A.C. 222 Van der Mculen-Muileman, I. 214 Vander Velde, D.G. 173,195, 196, 198,

200, 204, 205, 206, 211, 220-223 Vanderwal, C.D. 221 Vanotti, E. 196, 203, 206, 210 Van Rozendaal, E.L.M. 206 Van Rozendaal, H.L.M. 216 Van Tellingen, O. 212 Van Veldhuizen, B. 206 Varenne, P. 197 Varese, M. 195, 198, 203, 205, 206 Vartosis, C. 43 Vega, J.M. 47 Veith, J.M. 195-197, 201, 210, 211 Velde, D.V. 205 Velder, J. 216 Veldhuis, H. 206, 222 Vemishetti, P. 222 Verdine, G.L. 186,223 Vernillet, L. 225 Vernon, L.P. 42 Victory, S.F. 202 Vishwakarma, RA. 205 Viterbo, D. 196, 220 Voges, R. 214 Volz, H. 46 Vorella, c.P. 224 Vos, S. 224 Vosburg, D.A. 221 Vrignaud, P. 195, 197 Vu, P. 204, 217 Vuilhorgne, M. 42, 50, 212 Vulpetti, A. 196,210

242

Vyas, D.M. 196, 197, 199, 201-204, 210-213, 222

Waditschatka, R. 50 Wahl, A. 102,204, 205 Waldner, A. 51 Walker, D.O. 206, 214 Walker, D.W. 213 Walker, K. 195, 224 Walker, M.A. 181,222 Wall, M.E. 193, 194 Wallace, B.A. 218 Wallace, S. 214 Walsh, J.J. 220, 221 Walsh, V. 222 Walters, R.S. 194 Wandless, TJ. 155,217 Wang, D.-H. 216 Wang, H.-K. 223 Wang, H.-S. 218 Wang, M. 203, 221-223 Wang, T. 197,201,206,212 Wang, T.-H. 218 Wang, W 43 Wani, M.e. 193, 194 Warren, MJ. 50 Watanabe, N. 44, 45 Watanabe, Y. 216 Weaver, D. 200 Webb, N.L. 201, 223 Weber, B. 50 Weber, H. 51 Weed, S.D. 203 Weghom, SJ. 44 Wei, J.-M. 198-204,222 Wei, L. 221 Weil, M. 218 Weiler, S. 221 Wender, P.A. 95, 163,203, 217 Westwood, S.W. 46,49 Whittaker, M. 218 Wicnienski, N.A. 195, 196, 203, 206 Wiedemann, E. 42 Wiegerinck, P.H.O. 213, 216 Wikstrom, M. 43 Wildung, M.R. 224 Williams, A.D. 217 Williams, D.e. 48, 224 Williams, H.J. 50, 173,219,220 Williams, R.M. 186,223, 224

Author Index

Williamson, I.S. 195 Williard, P 51 Wilson, C.R. 222 Wilson, K.S. 45 Winkler, J.D. 176, 221 Wintner, e.E. 47, 50 Wirth, e. 214 Wirth, O. 50 Witman, PA. 223 Witt, H.T. 44 Wittman, M.D. 202, 203, 222 Woerner, O. 51 Woggon, WD. 49 Wolf, S.O. 218 Wolfe, R.S. 33, 50 Wolff, A.C. 223 Wong, H. 202,211,213 Wong, H.S.L. 213 Woods, e.M. 220 Woodward, R.B. 20,21, 37, 46, 50 Womer, O. 50 Wrasidlo, W 200, 220, 223 Wright, J.J.K. 202, 213 Wright, M. 201, 212, 215 Wroblewski, A.E. 209 Wu, J.H. 224 Wu, M.-J. 222 Wu, Q. 202 Wu, W 43,48 Wu, Y.-T. 214 Wu, Z.-J. 221 Wuts, P.O.M. 125, 129,209, 210

Xia, J. 214 Xia, X. 221 Xue, M. 202, 210, 212

Yagi, A. 44, 45 Yamada, K. 208 Yamada, T. 216, 217 Yamaguchi, M. 222 Yamaguchi, T. 210, 213 Yamamoto, H. 119,208 Yamamoto, K. 44, 45 Yang, e.-P.H. 202, 219 Yang, DJ. 214 Yang, Z. 217 Yap-Bondoc, F. 49 Ye, Q.-M. 205 Yeung, e.M. 199, 201, 203, 205

Author Index

Yin, D. 216 Yin, D.L 200 Yogai, S. 217 Yoon,l. 209 Yoshino, T. 201, 222 Yoshinori, S. 216 Young, W.B. 217 Yu, c.-Z. 205 Yu, D. 214 Yuan, H. 177,203,204,221

Zagalak, B. 42 Zaharevitz, D. 221 Zaitseva, N.!. 48 Zalkow, LH. 213 Zamir, LO. 107, 185, 189,205, 206, 216,

223,224 Zehnder, Al.B. 50 Zhang, O. 222

Zhang, P. 204, 217 Zhang, Z. 197 Zhao, M. 206 Zhao, Z. 213 Zheng, Q.Y 195, 197 Zheng, YF. 205 Zhu, 1. 220 Zhu, Q. 221 Zierath, P.D. 44 Zimmermann, S.c. 46 Zipfel, F. 51 Zjawiony, 1.K. 207 Zoeckler, M.E. 202, 222 Zucchetti, M. 196, 212 Zucco, M. 195, 199, 200, 206, 207 Zumft, W.O. 49 Zurio, M.O. 225 Zutter, UJ. 51 Zygmunt, 1. 197, 201, 211

243

Subject Index

11(15---+ 1)-Abeo-5-epi-20,0-secotaxol 106 11(15---+ l)-Abeotaxoids 57 II (15---+ I)-Abeotaxols 106 Absidia coerula 185 ABT-27I 185 Acetaldehyde 41 Acetic acid 6,7,12,13,39-41,58,59,126 Acetic anhydride 67, 74, 150 Acetone 107, 162, 164, 165 Acetonitrile 71, 88, 92 Acetoxy acetyl chloride 113 Acetoxy acyl chloride 113 13-Acetylbaccatin III 74 Acetyl chloride 67, 99, 106 13-Acetyl-IO-deacetoxy-7-methoxycarbo-

nylbaccatin III 82 13-Acetyl-lO-deacety 1-7 -epibaccatin III 81 13-Acetyl-9-dihydrobaccatin III 92, 109,

III lO-Acetyldocetaxel 66, 130 13-Acetyl-7-epibaccatin III 148 2-Acetyl-7-epi-taxol 90 13-Acetyl-7-(triethylsilyl)baccatin III 61 Acrolein 121 Acrylic acid 28 17 -Acrylic acid 28 Acyltunichlorin 15 Acyltunichlorinmethylester 15 Adenosylcobinamide 38, 40 S-Adenosyl methionine 19,29,34-37,

39,41 S-Adenosyl methionine uroporphyrinogen

III methyl transferase 34, 35 Adriamycin 25 lO-Allyl docetaxel 69 Am berli te 400 116 3'-N-(m-Aminobenzoyl)taxol 172 Aminolevulinic acid 8 D-Aminolevulinic acid 6, 7, 29, 36, 39 Aminophosphates 140 l-Amino-2-propanol 40 Ammonium chloride 71

Ammonium persulfate 123 ,i)-Amyloid toxicity 171 Antibiotics 11 Anticancer activity 56, 64, 129, 137,

170 Antileukemic activity 56, 170 Antipemicious activity 2 Antiproliferative activity 153 Antitumor activity 65, 139, 140, 170 Apoptosis 170 Archaebacteria 41 13-Azabaccatins 62 13-Azataxol analogs 61 13-Azidobaccatin III 61 3'-(p-Azidobenzamido)taxol 171 2-(m-Azidobenzoyl)baccatin III 178 2-(m-Azidobenzoyl)taxol 171

Baccatin III 57, 58, 60, 61, 66-68, 71,74,80,87,88,96,97, 100-102, 108, 111-113, 119, 122, 124, 126--129, 137, 148, 156, 160, 162-165,168,179,181,186, 189-192

Baccatin VI 80 Bacteriochlorins 4, 23, 25, 27 Bacteriochlorophyll a 2, 23 Bacteriochlorophyll b 23 Bacteriochlorophyll c 15 Bacteriochlorophyll d 15 Bacteriochlorophyll e 15 Bacteriochlorophyll g 23 Bacteriochlorophylls 14, 23, 25 Barton procedure 75, 79, 80 Barton's deoxygenation protocol 133 Barton's radical deoxygenation reaction 88 Barton's reagent 70 Bayer-Villiger oxidation 16 Benzaldehyde 121 Benzene 166 Benzeneseleninic anhydride 159 Benzoy I chloride 99

246 Subject Index

I-Benzoyl-2-debenzoyloxytaxol 79 Benzoyl peroxide 87 N-Benzoyl-3-phenylisoserine 124 Benzylamine 103 O-Benzylhydroxylamine 72 2' -(Benzyloxycarbonyl)-7 -epi-taxol 90 2' -(Benzyloxycarbonyl)-7 -(triethylsilyl)-

taxol 136 Benzyloxymethyl chloride 159 Bilanes 14 Biological activity 3, 16, 72, 183, 191 7,13-Bis(triethylsilyl)baccatin III 97 2',7 -Bis(triethylsilyl)taxol 106 7,10-Bis(triethylsilyl)-13-(trimethylsilyl)-

10-deacetylbaccatin III 97 7,IO-Bis-troc-lO-deacetylbaccatin III 127 Bonellia viridis 16 Bonellin 16, 17,20,21 Bonellin dimethylester 2 1, 22 (-)-Borneol 157 Borohydride 148, 150 Boron trifluoride etherate 103, 112 Breast cancer 56 Breast cancer LCC6 83, 176 Breast cancer MCF7 86 Breast cancer MCF7-ADR 84 Breast cancer MCF7-R 84 Bromine 93 I-Bromo-3-methyl-2-butene 164 3"-Bromotaxol 142 Burgess' reagent 159 Butitaxel 132 3-(t-Butoxycarbonylamino)-2,2-difluoro-

3-phenylpropanoic acid 133 t-Butyl alkoxide 22 t-Butylamine 135 2' -(tert-Butyldimethylsilyl)-l O-deacetyJtaxol

66 2' -(t-Butyldimethylsilyl)-7-epi-lO-deacetyl­

taxol 65 2'-(tert-Butyldimethylsilyl)taxol 66 2' -(tert-Butyldimethylsilyl)-7 -(triethylsilyl)-

2-debenzoyltaxol 82 2' -(tert-Butyldimethylsilyl)-7 -( triethylsilyl)-

taxol 72 7-(t-Butyl diphenylsilyl)baccatin III 148 t-Butylhydroperoxide 149, ISO 2-(tert-Butylimino )-2-( die thy lamino)-

I ,3-dimethylperhydro- I ,2,3-diazophos­phorine 22

Camphorsulfonyloxazidiridine 158 (+ )-Camphorsulfonyl oxazidiridine 158 Camphor sulfuric acid I I I Carbon disulfide 88 [Carbonyl-14C]-acetic anhydride 143 7 -([Carbonyl-14C]-acetyl)taxol 143 Carbonyl- 14C-benzaldehyde 143 N-3'-[Carbonyl- 14C]-taxol 143 Carboxylic acid 6, 21, 40, 123 7 -( 4-Carboxy-2,2,6,6-tetramethyl-I-piperidi-

nyloxy)-taxol 147 Catalases 9 Cephalomannine 58, 135, 136 Ceric chloride 72, 73, 96 Chiral diamine 168 Chiral sulfonamide esters I 13 Chlorins 4, 14, 16, 20, 2 I Chloroacetic acid 87 Chloroacetic anhydride 67 Chlorobiaceae 14 Chlorocruorin 10 Chlorocruoro heme 9, 10 Chloroflexaceae 14 Chloroform 93, 173, 178 Chlorohydrin 116 anti-3-Chloro-2-hydroxy-3-phenylpropano-

ate 186 syn-3-Chloro-2-hydroxy-3-phenylpropano-

ate 186 Chloromethyl methyl ether 87 m-Chloroperoxybenzoic acid 183 Chlorophyll a 2, 14-16, 18-22,33 Chlorophyll b 14, 15 Chlorophyll CI II Chlorophyll C2 1 I Chlorophyll C3 II Chlorophyll d 14, 15 Chlorophylls 4, 6, 12, 13, 20, 25, 39 Chlorophyllase 19 Chlorophyllide a 18, 19, 23, 24 Chlorophyll one a 15, 16 Chlorophyl\one lactone a 16 Chromatium vinosum 41 5-Cinnamoyltaxicin I 188 O-CinnamoyJtaxicin I 110 Cinnamoyltaxicin I acetates 1 10 5-Cinnamoyltriacetyltaxicin I lSI Cinnamyl acetate 123 Cinnamyl alcohol 123 cis-Cinnamyl alcohol 116

Subject Index 247

trans-Cinnamyl alcohol 116 Claisen rearrangement 31 Clostridium tetanomorphum 17 Cobalt 41 Cobalt(I) 41 CobaIt(Il) 40 Cobalt(IlI) 41 Cobyrinic acid-a,c-diamide 38-41 Cobyrinic acid heptamethylester 29 Collidine 140 Collins reagent 61 Comparative molecular field analysis 178 Compound-4 34, 35 Copper deuteroporphyrin dimethylester 32 Co-Precorrin-3A 40, 41 Co-Precorrin-4 40, 41 Co-Precorrin-5 40,41 Co-Precorrin-6X 41 Coproporphyrin III 9, 10 Coproporphyrinogen III 13 Corallistes sp. 11 Corallistin a 11 Corallistin b II Corallistin c 11 Corallistin d 11 Corallistin e 11 Corphin 4, 5, 35 Corrinoids 41 Corrins 3, 5, 29, 36, 41 Cosynthase 8 Crabtree's catalyst 164 Cupric acetate 65, 96 Cupric chloride 122 Cuprous bromide 58 Cyc1opheophorbide 15, 16, 20, 22 7,8-Cyc1opropataxol products 90 Cytochrome cd! 27 Cytochrome d 18 Cytochrome 0 18 Cytochrome P450 191 Cytochromes 9 Cytochromes c 10 Cytotoxic activity 56,58-61,63-65,68,70,

72-75,78-80,83,84,87-91,93,95,96,99, 100,103,104,107,109,130--133,135,137, 141,143,144,149-152,154,155,170,176, 177,180--184,186,188,189

Darwinella oxeata 16 Daunorubicin 155

Davis' oxaziridine 164 2'-Deacetoxyaustrospicatine 102, 154 IO-Deacetoxybaccatin III 58,74, 88, 107,

109 I O-Deacetoxy-13, 14-dehydro-13-

azataxol 62 IO-Deacetoxy-9-dihydrobaccatin III 71 2-Deacetoxytaxinine J 81, 183 IO-Deacetoxytaxol 58, 70 IO-Deacetylbaccatin III 59-61, 66, 67,

69-71,74,78, 81, 89, 96, 103, 110, 148, 165, 181, 191

I O-epi- IO-Deacetylbaccatin III 73 1 O-Deacetylbaccatin III-I O-O-acetyItransfer­

ase 191 10-Deacetylbaccatin III-I0f3-0-acetyltrans-

ferase 192 4-Deacetyldocetaxel 97 IO-Deacetyl-19-hydroxybaccatin III 75 4-Deacetyl-13-oxo-7 -(triethylsilyl)baccatin

III 61 4-Deacetyltaxol 96, 97 IO-Deacetyltaxol 61,66,67 10-Deacetyltaxol-7-xyloside 148 Deaminase 8 Deaminoacyltaxine A 154 2-Debenzoylbaccatin III 79 2-Debenzoylbaccatins 77 3'-N-Debenzoyl-3'-dephenyl-3'-t-butyl-10-

deacetyltaxol 132 2-Debenzoyl-4,13-dideacetyl baccatin VI

111 N-Debenzoyl-N-(3-furoyl)taxol 132 2-Debenzoyl-2-oxobaccatin III 80 2-Debenzoyloxytaxol 79 N-Debenzoyltaxol 132 2-Debenzoyltaxols 77, 137 N-Debenzoyl-N-(2-thienoyl)butitaxel

132 IO-Dehydro- IO-deacetylbaccatin III III Dehydrotaxol 91 IO-Dehydroxydocetaxel 70 7-Deoxobaccatin III 103 Deoxophylloerythrin 11, 12 Deoxophylloerythroetioporphyrin 11, 12 9-Deoxotaxol 75 I-Deoxybaccatin III 81 7-Deoxybaccatin III 150, 151 2'-Deoxy-2'-(difluoro )docetaxel

derivatives 133

248 Subject Index

7 -Deoxydocetaxel 150 I-Deoxytaxol 80, 81, 83 2' -Deoxytaxol 133, 174 7 -Deoxytaxol 70, 88, 150, 151 3' -Dephenyl-3' -(2-furyl)-N-(hexanoyl)­

taxol 132 3' -Dephenyl-3' -(2-furyl)taxol 132 N-t-BOC-3' -Dephenyl-3' -(2-furyl)-

taxol 132 3' -Dephenyl-3' -(2-pyridyl)taxol 132 Dess-Martin periodinane 164 Dess-Martin reagent 89 7,I3-Diacetylbaccatin III 76, 102 1,2-Dichloroethane 91 7,9-Didcoxytaxol 75 7,10-Dideoxytaxol 70, 88 Diels-Alder cyclization 154 Diels-Alder cycloaddition 155 Diels-Alder reaction 158 Diels-Alder type reaction 124 Diethyl L-tartrate 186 9-Dihydro-13-acetylbaccatin III 148 (9R)-Dihydro-13-acetylbaccatin III 107 9-Dihydrobaccatin 73 (9R)-Dihydrobaccatin 75, 107 9-Dihydrobaccatin III 92 9cx-Dihydrodocetaxel 71 9;3-Dihydrodocetaxel 71 2,3-Dihydroporphyrin 4 Dihydrotaxol 59 9-Dihydrotaxol 73 Dilithium sulfide 103 Dimethoxypropane 122 2,2-Dimethoxypropane 160 Dimethyldioxirane 81,93 3,3-Dimethyldioxirane 162 Dimethylformamide 67 Dimethyl phosphite 126 2,2-Dimethylpropane-l ,3-diol 160 Dimethyl sulfide 87 Dimethylsulfonium ylide 181 1-(Dimethylsilyl)-7 -(triethylsilyl)-baccatin

III 61 Dimethyltunichlorin 15, 16 Dioxo-oxathiazolidine 127 Diphenyldiselenide 123 Di-2-pyridylcarbonate 133 Dipyrrylmethanes 14 Dipyrrylmethenes 14 Discodermolide 175

7, I O-Di(trichloroethoxycarbonyl)-l O-deace-ty Ibaccatin III 106

7,1 3-Di(triethylsilyl)baccatin III 65,76,82 2',7-Di(triethylsilyl)taxol 79 7, IO-Di(triethylsilyl)-13-trimethylsilyl-1 0-

deacetylbaccatin III 76 7,IO-Di-troc-baccatin III 69, 126, 128 7, I O-(Di-troc )-IO-deacetylbaccatin III 133,

143 2',7-Di-troc-10-deacetyltaxol 70 7, I O-Di-troc-docetaxel 106 7,IO-Di-troc-taxol 67 Docetaxel 56-60,66,68,69,71,74,75,

77, 78, 84, 88, 89, 91, 98, 103, 106, 115, 118, 121-123, 126, 128-132, 134, 136, 137,148,150,170,181,184,193

[3,_14C]-Docetaxel 143 DOCK protocol 191 Docosahexaenoic acid 187 Dodecahydroporphyrin 33

Electron crystallography 170 Eleutherobin 17 5 Enzyme prodrug therapy 141 ( + )-Ephedrine 121 7 -Epi -I O-dehydro-I O-deacety Ibaccatin III

III 7 -Epi-lO-deoxytaxol 88 Epipodophyllotoxin 188 2-Epitaxol 78 2' -Epitaxol 133 7-Epitaxol 87, 88 13-Epitaxol 61 Epothilone 176-178 Epothilone A 175 Epothilone B 175 Eschenmoser's salt 164 Escherichia coli 10, 17, 18,27,29,34,

191, 192 Ethanol 66 Ether 97 n-Ethylacetamide 67 Ethyl cinnamate 118, 186 Ethyl cis-cinnamate 117 Ethyl trans-cinnamate 117 Ethyl propiolate 164 Etoposide 188

Factor F 430 33, 36 Factor I 17-21,27,29,31,37

Subject Index 249

Factor I octamethylester 21 Factor n 27, 29, 37 Factor ill 27, 29 Factor SI 34,35 Factor S3 34, 35 Auorescence activity 145 Auorescence spectroscopy 171 Auorescent taxol derivatives 190 3' -( 4-Auorophenyl)-1 0-

acetyldocetaxel 131 3'-( 4-Auorophenyl)docetaxel 131 3' -( 4-Auorophenyl)-N-( 4-fluorobenzoyl)-

taxol 132 Auorotaxol 91 2' -Auorotaxol 133 Autax-l 146, 173 Autax-2 146, 173 Formic acid 130 IO-Formyl-lO-deacetylbaccatin ill 67 Friedel-Crafts acylation 32

Geiparvin 176 Geoporphyrins 12 Geranylgeranyl diphosphate 191, 192 Geranylgeranylpyrophosphate 19 Girard's reagent 136 Glutamic acid 6 L-Glutamic acid 32 Glutamine 40 cis-Glycidic acids 128 Glycine 6 Grignard reagent 134 Guttiferone E 176

6a-Halotaxols 183 Hansenula fabianii 124 Hansenula polymorpha 124 Hansenula sp. 124 Harderoporphyrin 9, 10 Harderoporphyrinogen 12 Heck reaction 162 Hematoporphyrin 9, 10 Hematoporphyrin dimethylester 32 Heme 2,9, 10, 13, 14, 19, 32, 39 Heme a 9,10 Heme c 9, 10 Heme d 17, 18,20,22 Heme d l 27-29,31, 32 Heme 0 9,10 Hemes 6,9, 10, 12, 18

Hemoglobin 9, 10 Hemoproteins 10 2-0-Heteroaroyl taxanes 78 Hexahydrobaccatin ill 96 Hexahydroporphyrinoids 5 Hexahydroporphyrins 5, 25 Homoallyl iodide 169 Human breast cancer LCC6-WT 176 Human breast cancer MDA-435 176 Human colon carcinoma HCT-116 93,

134 Human lung cancer H-1299 141 Human ovarian adenocarcinoma 24 Hiinig's base 135 Hydrazine 65,72 Hydrochloric acid 27, 89 Hydrogen donors 14 Hydrogenobyrinic acid 38 Hydrogenobyrinic acid-a,c-diamide 40 Hydrogen peroxide 66 Hydrogensulfide 14 Hydroporphyrinoids 3 Hydroporphyrins 14, 21, 32 a-Hydroxy-j3-amino acids 186 14j3-Hydroxybaccatin ill 68 14j3-Hydroxy-lO-deacetylbaccatin ill 62,

63, 110 12-Hydroxy-11,12-dihydrobaccatin 59 20-Hydroxy-4,5-ene-7-oxotaxinine 154 a-Hydroxy-a-methyl-j3-amino acids 186 14j3-Hydroxy-13-oxo-baccatin ill 180 14-Hydroxytaxoids 62 6a-Hydroxytaxo1 93, 136, 182

Imidazole 160, 167, 168, 181 lodobromide 104 N-Iodosuccinimide 26, 87 Isobacteriochlorins 4, 27, 29 Isolaulimalide 176 Isopropanol 181 12,13-lsotaxanes 91 Isotaxine B 149 Isotaxoids 91 Isotaxol 59 12,13-Isotaxol 91 Isothiocyanate 147

Jones' reagent 148

a-Keto-j3-amino esters 124

250 Subject Index

Laulimalide 176 Lawesson's reagent 22, 26, 30 Lead tetracetate 95 L-Leucine 185 Leukemia L-1210 137 Leukemia P-388 79 Lewis acid catalyst 67, 166 Lipase MAP-IO 125 Lithium aluminum hydride 97 Lithium chloride 61,67 Lung carcinoma M-109 135, 139, 140,

182, 183 2,6-Lutidine 160, 162, 164, 166-168

Magnesium 19 Malacosteus niger 15 Mammalians 10 McMurry coupling 159 Meerwein's reagent 101 Melanoma B-1 137 Melanoma B-16 58,91,131,132,

180 Mercuric chloride 122 Mesyl chloride 67, 103, 106 Methane 33 Methanol 21, 22, 58, 66, 76, 107 Methanolic ammonia 61 Methionine 36 13C_ Methionine 36 4-Methoxy-2-oxazolidinones 122 2-Methoxypropene 159, 164, 167 2'-Methoxytaxol 133, 174 Methylated hydroporphyrins 34 Methyl cinnamate 118 2'-Methyldocetaxel 134 Metbyl iodide 88, 110, 133 N-Methylmaleimide 155 (S)-O-Methylmandelate esters 126 Methylpheophorbide a 22 N-Methylpiperazine 87 2'-Mcthyltaxol 134 2-(Methylthio )-cthanesulfonate 33 Methyl triflate 98 Mg-porphyrin 19 Microtubule dcpolymerization activity

154 Microtubule-stabilizing activity 154 Mitsunobu procedure 117 Mitsunobu-type reaction 121 Multidrug resistance 24, 171

Murine tumor M-I09 135, 139, 140, 182, 183

Myoglobin 9, 10

Naphthalene sulfonic acid 162 10-O-Nicotinyltaxol 180 Niobium trichloride 134 Nitric oxide 27, 171 Nitrogen 130 p-Nitrophenylchloroforrnate 135 Nitrous oxide 27 Noesy experiment 69 Nonataxel 176 19-Nor-7,8-cyclopropataxol 91 A-Nortaxanes 108 A-Nortaxoids 57 A-Nortaxols 106-108 Nuclear Overhauscr effect 174 9-(Nucleosidosuccinoyl)-7 -deoxytaxol

analogs 151

Octreotide 141, 142 Optical activity 10, 21, 115 Organosilanes 69 Organostannanes 69 Ovarian cancer 56 13-0xobaccatin III 110 1 O-Oxo-l O-deacetylbaccatin III 72 13-0xo-lO-deacetylbaccatin III 58, 61 7 -Oxotaxol 89 13-0xo-7-triethylsilyl-10-deacetylbac-

catin 76

Paclitaxel 56, 72, 130 Palladium 142 Paracoccus denitrificans 27, 35 H-Patchino 157 Pemptoporphyrin 9, 10 Penicillium vitale 17 Peracetic acid 158 Periodate 63, 82 Peroxidases 9 Phenylboronic acid 158 Phenyldimethylsilane 101 o-Phenylenediamine 135 N-Boc-Phenylglycinal 126 (L)-Phenylglycine 123 Phenylhydrazine 148 Phenyllithium 98, 100 Phenyl magnesium bromide 121

Subject Index 251

Phenylselenyl triflate 123 3'-Phenyl taxanes 132 Photodynamic tumor therapy 14 Photosensitizing activity 25 Photosynthesis 14 Photosynthetic activity 16 Phototoxic activity 10 Phytylpyrophosphate 19 Pinacol 166 Pinene 164 Plasmin 142 P~-105298 143 PNU-166945 192 2' -(Polyethyleneglucol) esters 140 Porphobilinogen 6--8 Porphobilinogen desaminase 6 Porphobilinogen synthase 6 Porphyrin d 1 28, 31, 32 Porphyrin SAIl 9, 10 Porphyrins 3,4, 6, 8-14,21, 33, 36 Porphyrinogen 4, 5, 35 Porphyrinogens 6, 8, 10 Porphyrinoids 3, 5, 14, 24 Potassium tert-butoxide 69, 77, 96, 97 Potassium carbonate 110 Potassium osmate 118 Potassium thioacetate 182 Precorrin-l 17, 29, 37 Precorrin-2 29, 35, 37 Precorrin-2 type I 34 Precorrin-3 29, 41 Precorrin-3A 38, 39 Precorrin-3B 38, 39, 41 Precorrin-4 39 Precorrin-5 38, 39 Precorrin-6A 38, 39,41 Precorrin-6B 39 Precorrin-6X 38 Precorrin-8 38 Precorrin-8X 38, 40 Propargyl alcohol 166 Propionibacterium shermanii 17, 35, 40 Propionic acid 6,7, 12, 13,29,40 13-Propionic acid 19 17-Propionic acid 14, 16, 19 Protaxel 188 Protaxols 140 Protein Bcl-2 170 Protochlorophyllide 18, 19 Protoporphyrin IX 9, 10, 12, 13, 18, 19,28

Protoporphyrin IX dimethylester 22 Protoporphyrinogen IX 12, 13 Pseudomonas aeruginosa 27 Pseudomonas cepacia 67, 110 Pseudomonas denitrificans 39 Purpurin 18 16 Pyridine 92, 109, 150 Pyridinium p-toluene sulfonate 106 Pyrrocorphin 4, 5, 35 Pyrrole D 6 Pyrroles 14 Pyrrolidine 72 Pyruvic acid 134

Racemic oxazoline 123 Raf-l kinase 170 Raney nickel 62 REDOR technique 174 Redox enzymes 3 Rhazinilam 176 Rhodamine B 147 Rhodophytes 14 Rhodospirillum rubrum 41 Ruditapes philippinarum 16

Salmonella typhimurium 35 Samarium iodide 71 Scandium trifluoromethane sulfonate 67 Schotten-Baumann acylation 132 A-Seco derivatives 63 D-Secotaxol 105 D-Secotaxol analogs 174 K-Selectride 169 L-Selectride 162 Selenium 107 Shapiro reaction 159 Sharpless catalytic asymmetric aminohy-

droxylation 118 Sharpless epoxidation 116 Sharpless protocol 135 Silica gel 59, 91, 114, 161 Sil ver nitrate 114 Silver oxide 133 Silver triflate 87 7-Silyl-baccatin III 129 Sinenxan A 152 Siroheme 27-29, 34 Siroheme synthase 29 Sirohydrochlorin 27, 31, 32 Sirohydrochlorin octamethylester 31

252 Subject Index

Sirohydrochlorins 29 Sodium acetate 67 Sodium azide 128 Sodium bicarbonate 66 Sodium borohydride 58, 72, 74, 96 Sodium eHJ-borohydride 145 Sodium hydride 69, 87, 88, 110 Sodium hypochlorite 117 Sodium iodide 88 Sodium e23IJ-iodide 143 Sodium methoxide 110, III Sodium periodate 94 Sodium triacetoxyborohydride 94 Somatostatin 141, 142 Soret band 3 Spirographis heme 9 Succinyl CoA 6 Sulfide contraction procedure 26 Sulfur 21 Swern oxidation 134, 158 Synthon 143, 167, 168

Taxacin I derivatives 154 Taxadiene 192 Taxa-4(5),1I(l2)-diene 191 Taxadiene 5a-hydroxylase 191 Taxadiene synthase 191, 192 Taxa-4(20),11 (l2)-dien-5a-ol 191 Taxadien-5a-ol-O-acetyltransferase 192 Taxa-4(20), II (l2)-dien-5a-ol-O-acetyltrans-

ferase 191 Taxagifine 60 Taxane 2a-O-benzoyltransferase 192 Taxane diterpenoids 57 Taxane 10;3-hydroxylase 191, 192 Taxanes 132,141,154,171,179,181,185,

192 Taxicin I Taxine Taxine B Taxinine

110 148, 150, 183

103, 108, 149 152

Taxinine B 154 Taxoids 57,58,68, 105, 108, 113, 131 Taxol 56-58, 60, 61, 63-88, 90-93,

95-109,112,113,115-119,121, 122, 124, 126-148, 151, 153-157, 161,165,169-179,181-193

[3'_14C]_ Taxol 143 [2' ,3' -14C2J_ Taxol 143 T-Taxol 191

Taxotere 56, 129 Taxus baccata 154 Taxus brevi/olia 56, 170 Taxus canadensis 73 Taxusin 157 Taxuspine 189 Tetraaza[ 16Jannulene 4, 5 Tetrabutylammonium acetate 150 Tetrabutylammonium borohydride

59,61 Tetrabutylammonium bromide 103 Tetrabutylammonium fluoride 121 Tetrabutylammonium iodide 104 Tetrabutylammonium nitrate 94 Tetradecarboxylated coproporphyrinogen

III 12 2,3,7,8-Tetrahydroporphyrin 4 2,3,12,13-Tetrahydroporphyrin 4 Tetramethylammonium triacetoxyborohy-

dride 61 Tetrapropylammonium perruthenate 95 Thiobacillus denitrificans 27 Thionyl chloride 94, 117 Thiourea 67 Thio-Wittig reactions 30 Titanium trichloride 159 Toluene 159, 165-169 p-Toluenesulfonic acid 107, 110 Tolyporphin A 24, 25, 27 Tolyporphin B 24, 25 Tolyporphin C 24, 25 Tolyporphin D 24, 25 Tolyporphin E 24, 25 Tolyporphin F 24, 25 Tolyporphin G 24, 25 Tolyporphin H 24, 25 Tolyporphin I 24, 2S Tolyporphin J 24, 25 Tolyporphin K 24, 25 Tolyporphins 24 Tolypothrix nodosa 24 Topliss approach 129 Topoisomerase II 188 (2R,3S)-N-Tosyl-3-phenyl isoserine 118 Tributyltin hydride 88 Tributyltin methoxide 76, 102 Trichloroacetic acid III Trichloroethoxy carbonyl chloride 63 7,9,10-Trideoxytaxol 75 Trididemnum solidum 16

Subject Index 253

Triethylamine 106 Triethylphosphite 26 7-(Triethylsilyl)baccatin III 78, 96, 97,

108, 133, 143 13-eHJ-7-Triethylsilylbaccatin III 142 7 -(Triethylsilyl)-l O-deacetylbaccatin

III 68, 76, 102 2'-Triethylsilyl-l0-deacetyl-7-epitaxol 68 2'-Triethylsilyl-7-epitaxol 88 7-(Triethylsilyl)hexahydrobaccatin III 66 7-(Triethylsilyl)-13-oxobaccatin III 59,

109, 142 7 -(Triethylsilyl}-13-oxo-1 O-deacetylbaccatin

III 100 5-0-(Triethylsilyl)taxinine A 112 2'-(Triethylsilyl}taxol 88, 143 Triflic anhydride 65, 67, 92 Trifluoroacetic acid 27, 10 I, 106 Trifluoroacetic anhydride 109 Trifluoromethane sulfonic anhydride 109 2,4,6-Triisopropylbenzenesulfonylhydrazide

160 Trimethylpyrrocorphin 34, 35 Trimethylpyrrocorphin type I 34, 35 Trimethylsilyl chloride 10 I Triphosgene 164-167 Tritium 142 Triton B 77 Tubulin 56, 90, 105, 142, 144, 145, 147,

153, 154, 169-177, 184, 189, 190 Q-Tubulin 171 i3-Tubulin 171, 189

Qi3-Tubulin 189 Tubulin-assembly activity 152, 154, 170,

176, 184 Tubulin inhibitory activity 153 Tumor necrosis factor 171 Tumor P-388 133 Tunichlorin 15, 16, 20, 22 Tyrosine phosphorylation 171

Uroporphyrin I 10 Uroporphyrin III 10 Uroporphyrinogen I 7, 8, 34, 35 Uroporphyrinogen III 5-8, 12, 13, 17, 19,

20, 27, 29, 33-39 Uroporphyrinogen III methylase 34 Uroporphyrinogens 8, 9

Verapamil 154 Verbenone 164, 165 Vinblastine 25 Vitamin BIZ 2,3,5,17,18,27,29,32,33,

35-37, 39-42

Woodward-Hoffmann rules 37 WS9885B 176

Yarovenko's reagent 70 Yew alkaloids 179

Zinc 58, 59, 104, 126 Zinc(II) 22, 26 Zinc bromide 66

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