Author Year Journal Total · 2013. 11. 12. · CV mortality Diabetes Mellitus (DM) Ahdout J 2012 Clin Exp Dermatol Alexander E 2001 IJDVL Al-Mutairi N 2010 J Dermatol Armesto S 2011

Author Year Journal Total

Cardiovascular disease (CVD)Choi WJ 2010 Ann DermatolMcDonald CJ 1978 British Journal of Dermatology

CVD TotalCVD in total (CVD+IHD+ cerebrovascular disease)

HosPop (Overall)Pop-EI (ExcludinPop (Health insuPsAPsO

Ischemic Heart Disease (IHD)Ahlehoff O 2010 J Int MedAl-Mutairi N 2010 J DermatolArmesto S 2011 JEADVChen YJ 2008 Arch DermatolCohen AD 2007 G Ital Dermatol VenereolDriessen RJB 2009 J Dermatolog TreatEna P 1985 Acta CardiolGelfand JM 2006 JAMAGerdes S 2008 BJDGladman DD 2009 Ann Rheum DisHan C 2006 J RheumatolKadry D 2012 JEADVKimball AB 2008 DermatolNaldi L 2008 DermatolMebazaa A 2011 JEADVPereira RR 2011 Indian J DermatolSchmitt J 2009 JEADVSommer DM 2006 Arch Dermatol ResSu YS 2012 JEADVWakkee M 2009 J Invest DermatolWarnecke C 2011 Eur J DermatolXiao J 2009 JEADV

Total IHDHosPop (Overall)Pop-EIPop (health insuPsAPsO

Cerebrovascular DiseaseAhdout J 2012 Clin Exp DermatolAhlehoff O 2010 J Int MedCohen AD 2007 Acta Derm VenereolDriessen RJB 2009 J Dermatolog TreatGelfand JM 2009 J Invest DermatolGerdes S 2008 BJDGladman DD 2009 Ann Rheum DisHan C 2006 J RheumatolKimball AB 2008 DermatolMebazaa A 2011 JEADV

Schmitt J 2009 JEADVSu YS 2012 JEADVWarnecke C 2011 Eur J Dermatol

Total cerebrovasHosPop (Overall)Pop-EIPop (health insuPsAPsO

Peripheral Vascular Disease PVD)Cohen AD 2007 Acta Derm VenereolHan C 2006 J RheumatolWarnecke C 2011 Eur J DermatolYang YW 2011 BJD

Total PVD

AtherosclerosisHan C 2006 J RheumatolShapiro J 2007 JAAD

Total atheroscler

Cardiovascular (CV) mortalityAhlehoff O 2010 J Int MedMehta NN 2009 Eur Heart J

CV mortality

Diabetes Mellitus (DM)Ahdout J 2012 Clin Exp DermatolAlexander E 2001 IJDVLAl-Mutairi N 2010 J DermatolArmesto S 2011 JEADVAzfar RS 2012 Arch DermatolBalci A 2009 DermatolBinazzi M 1975 Arch Dermatol ResBongiorno MR 2010 JEADVBrownstein MH 1966 Arch DermatolChen YJ 2008 Arch DermatolChoi WJ 2010 Ann DermatolCohen AD 2008 JEADVDriessen RJB 2009 J Dermatolog TreatEna P 1985 Acta CardiolFisher JE 1928 Arch Derm SyphilolGelfand JM 2009 J Invest DermatolGerdes S 2008 BJDGhiashi M 2011 Indian J DermatolGibson SH 1956 AMA Arch DermGisondi P 2007 BJDGoulding JMR 2010 BJDHan C 2006 J RheumatolInerot A 2005 BMC DermatolKadry D 2012 JEADVKaradag AS 2010 Int J DermatolKimball AB 2008 DermatolKimhi O 2007 Semin Arthritis Rheum

Lojander W 1928 Acta Derm VenereolLudwig RJ 2007 BJDLutsey PL 2012 J Thromb HaemostLynch PJ 1967 Arch DermatolMadagobalane S 2012 Indian J Dermatol Mebazaa A 2011 JEADVMehta NN 2012 AtherosclerosisNaldi L 2008 DermatolNisa N 2010 Indian J Dermatol Venereol LeprolOllendorff-Curth 1966 Arch klin Exp DermPereira RR 2011 Indian J DermatolPick W 1921 Dermatologische WochenschriftProdanovich S 2009 Arch DermatolQureshi AA 2010 Arch DermatolSundharam JA 1980 Indian J Dermatol Venereol LeprolSchmitt J 2009 JEADVShapiro J 2007 JAADSolomon DH 2010 Ann Rheum DisSommer DM 2006 Arch Dermatol ResSu YS 2012 JEADVTam L 2008 RheumatologyWakkee M 2009 Acta Derm VenereolWarnecke C 2011 Eur J DermatolXiao J 2009 JEADVZindanci I 2012 The scientific world journalTobin AM (Excluded in STATA) 2011 Clin Exp Dermatol

Total DMHosPop (Overall)Pop-EIPop (health insuPsAPsO

Hypertension (Hyp)Ablin JN 2009 Rheumatol IntAblin JN 2009 Rheumatol IntAhdout J 2012 Clin Exp DermatolAlexander E 2001 IJDVLAl-Mutairi N 2010 J DermatolArmesto S 2011 JEADVAzfar RS 2012 Arch DermatolBalci A 2009 DermatolBongiorno MR 2010 JEADVChen YJ 2008 Arch DermatolChoi WJ 2010 Ann DermatolCohen AD 2008 DermatolDe Simone C 2011 Eur J DermatolDriessen RJB 2009 J Dermatolog TreatEna P 1985 Acta CardiolGelfand JM 2009 J Invest DermatolGerdes S 2008 BJDGisondi P 2007 BJDGhiashi M 2011 Indian J DermatolGladman DD 2009 Ann Rheum DisGoulding JMR 2010 BJD

Han C 2006 J RheumatolKadry D 2012 JEADVKimball AB 2008 DermatolKimhi O 2007 Semin Arthritis RheumLudwig RJ 2007 BJDMadagobalane S 2012 Indian J Dermatol Mebazaa A 2011 JEADVMehta NN 2012 AtherosclerosisNaldi L 2008 DermatolNisa N 2010 Indian J Dermatol Venereol LeprolPereira RR 2011 Indian J DermatolProdanovich S 2009 Arch DermatolQureshi AA 2010 Arch DermatolSchmitt J 2009 JEADVSommer DM 2006 Arch Dermatol ResSu YS 2012 JEADVTam L 2008 RheumatologyTobin AM 2011 Clin Exp DermatolWarnecke C 2011 Eur J DermatolXiao J 2009 JEADVZindanci I 2012 The scientific world journal

Total HypHosPop (Overall)Pop-EIPop (health insuPsAPsO

DyslipidemiaAblin JN 2009 Rheumatol IntAblin JN 2009 Rheumatol IntAhdout J 2012 Clin Exp DermatolAl-Mutairi N 2010 J DermatolArmesto S 2011 JEADVAzfar RS 2012 Arch DermatolBongiorno MR 2010 JEADVBrustein DM 1976 LancetChen YJ 2008 Arch DermatolChoi WJ 2010 Ann DermatolCohen AD 2010 Acta Derm VenereolDe Simone C 2011 Eur J DermatolDriessen RJB 2009 J Dermatolog TreatEna P 1985 Acta CardiolGelfand JM 2009 J Invest DermatolGerdes S 2008 BJDGisondi P 2007 BJDGoulding JMR 2010 BJDHan C 2006 J RheumatolKadry D 2012 JEADVKimball AB 2008 DermatolKimhi O 2007 Semin Arthritis RheumLea WA 1958 J Invest DermatolMadagobalane S 2012 Indian J Dermatol Mebazaa A 2011 JEADVNaldi L 2008 Dermatol

Nisa N 2010 Indian J Dermatol Venereol LeprolOzturkcan S 2006 Annals of Saudi MedicinePereira RR 2011 Indian J DermatolProdanovich S 2009 Arch DermatolSchmitt J 2009 JEADVSommer DM 2006 Arch Dermatol ResSu YS 2012 JEADVTam L 2008 RheumatologyTobin AM 2010 Clin Exp DermatolWakkee M 2009 Acta Derm VenereolWarnecke C 2011 Eur J DermatolXiao J 2009 JEADVZindanci I 2012 The scientific world journal

Total dyslipidemHosPop (Overall)Pop-EIPop (health insuPsAPsO

Obesity by Body Mass Index (BMI)Al-Mutairi N 2010 J DermatolAhdout J 2012 Clin Exp DermatolArmesto S 2011 JEADVBongiorno MR 2010 JEADVChen YJ 2008 Arch DermatolChoi WJ 2010 Ann DermatolCohen AD 2008 DermatolDriessen RJB 2009 J Dermatolog TreatGelfand JM 2009 J Invest DermatolHerron MD 2005 Arch DermatolJin Y 2008 Journal of Dermatological ScienceMcGowan JW 2005 Arch DermatolKadry D 2012 JEADVNaldi L 2008 DermatolPedreira PG 2011 Arthritis Research & TherapyPedreira PG 2011 Arthritis Research & TherapyPereira RR 2011 Indian J DermatolSchmitt J 2009 JEADVTam L 2008 RheumatologyTobin AM 2011 Clin Exp DermatolWarnecke C 2011 Eur J DermatolWolk K 2009 Acta Derm VenereolZhang C 2010 JEADVXiao J 2009 JEADV

Total obesebmiHosPop (Overall)Pop-EIPop (health insuPsAPsO

Obesity by abdominal fat

Al-Mutairi N 2010 J DermatolArmesto S 2011 JEADVBongiorno MR 2010 JEADVGisondi P 2007 BJDMadagobalane S 2012 Indian J Dermatol Mebazaa A 2011 JEADVNisa N 2010 Indian J Dermatol Venereol LeprolPereira RR 2011 Indian J DermatolTam L 2008 RheumatologyZindanci I 2012 The scientific world journal

Total obesefatHosPsO

Metabolic SyndromeAl-Mutairi N 2010 J DermatolBalci A 2009 DermatolBongiorno MR 2010 JEADVChen YJ 2008 Arch DermatolChoi WJ 2010 Ann DermatolGisondi P 2007 BJDKadry D 2012 JEADVMadagobalane S 2012 Indian J Dermatol Mebazaa A 2011 JEADVNisa N 2010 Indian J Dermatol Venereol LeprolPereira RR 2011 Indian J DermatolSommer DM 2006 Arch Dermatol ResArias-Santiago S 2012 Eur J DermatolTam L 2008 RheumatologyZindanci I 2012 The scientific world journal

Total MetsPsO

AbbriviationsNS Non-specifiedHos Hospital-based studiesPop (Overall) Population-based studies (Overall)Pop-EI Population-based studies (Excluding health Insurance databPop (health Insurance database) Population-based studies (Health insurance database studiePsA Studies where inclusioncriteria was psoriasis and/or psoriaticPsO Studies where inclusion criterai was psoriatic arthritis

Study design Cases in total Controls in total Cases exposed in total Cases not exposed in total

case control 197 401 9 188case control 323 325 26 279

520 726 35 467503686 29686694 17260 47937611843 19777018 719 11106491843 9909676 16541 468270

ng health Insura370717 9183728 9664 361053urance databas 121126 725948 6877 107217

10520 19780633 625 9895493166 9906061 16635 469481

Cohort 36992 4003265 609 36383case control 1790 1835 79 1711case control 661 661 43 618case control 77 81 7 70case control 16851 74987 2393 14458case control 107 396 4 103case control 100 100 26 74case control 130976 556995 2337 128639case control 1131 7099 94 1037case control 648 9877292 83 565case control 3066 12264 224 2842case control 20 10 1 19case control 46170 183963 2931 43239case control 560 690 10 550case control 164 216 11 153case control 77 92 2 75case control 3147 3147 73 3074case control 581 1044 32 549Cohort 8180 163600 695 7485Cohort 15820 27577 583 15237case control 100 100 7 93case control 3092 1521 215 2877

270310 14916935 10459 2598519108 9891137 614 8494261202 5025798 9845 251357200639 4662824 5922 194717

rance database60563 362974 3923 566406806 9891077 522 6284263504 5025858 9937 253567

case control 65 52 5 60Cohort 36992 4003265 932 36060case control 340 6643 15 325case control 107 396 4 103case control 132746 510996 2795 129951case control 1131 7099 46 1085case control 648 9877292 8 640case control 3066 12264 95 2971case control 46170 183963 2128 44042case control 164 216 4 160

case control 3147 3147 36 3111Cohort 8180 163600 695 453case control 100 100 3 97

scular disease 232856 14769033 6766 2190582215 9885155 70 2145230641 4883878 6696 216913170078 4520904 3742 166336

rance database60563 362974 2954 505773714 9889556 103 3611229142 4879477 6663 215447

case control 340 6643 15 325case control 3066 12264 89 2977case control 100 100 3 97case control 1685 5055 37 1648

5191 24062 144 5047

case control 3066 12264 31 3035case control 46095 1579037 3595 42500

rosis 49161 1591301 3626 45535

Cohort 36992 4003265 1003 35989Cohort 3603 14330 108 3495

40595 4017595 1111 39484

case control 65 52 4 61case control 61 61 8 53case control 1790 1835 702 1088case control 661 661 79 582case control 108132 430716 3992 104140case control 46 46 7 39case control 200 280 83 117case control 400 348 100 300case control 94 94 18 76case control 77 81 20 57case control 197 401 17 180case control 16851 74987 2326 14525case control 107 396 14 93case control 100 100 14 86case control 13 39 2 11case control 132746 510996 6128 16926case control 1131 7099 104 1027case control 304 300 54 250case control 29 27 2 27case control 338 334 65 273case control 92 130 11 81case control 3066 12264 347 2720case control 536 202 11 525case control 20 10 7 13case control 75 50 11 64case control 46170 183963 5355 40815case control 47 100 5 42

case control 15 10 8 7case control 32 32 4 28case control 859 37749 94 765case control 213 358 61 152case control 118 120 72 46case control 164 216 30 134case control 122 134 10 112case control 560 690 21 539case control 150 150 27 123case control 65 65 3 62case control 77 92 25 52case control 17 12 14 3case control 3236 2500 883 2353case control 1813 76248 60 1753case control 20 20 6 14case control 3147 3147 421 2726case control 46095 1579037 3918 42177case control 40346 442033 1564 38782case control 581 1044 68 513Cohort 8180 163600 892 7288case control 102 82 19 83case control 9804 15288 706 9098case control 100 100 21 79case control 3092 1521 412 2680case control 115 140 56 59case control 20 20 0 20

432371 3549960 28881 29379914626 19730 3067 11559310274 3100175 21901 178682209365 2295168 13322 86351

rance database100909 805007 8579 923316307 13967 783 5525426064 3535993 28098 288274

case control 10 16 1 9case control 22 16 8 14case control 65 52 21 44case control 61 61 5 56case control 1790 1835 583 1207case control 661 661 200 461case control 108132 430716 27182 80950case control 46 46 4 42case control 400 348 109 291case control 77 81 26 51case control 197 401 64 133case control 16851 48681 4627 12223case control 32 31 6 26case control 107 396 37 70case control 100 100 37 63case control 132746 510996 23387 109059case control 1131 7099 286 845case control 338 334 138 200case control 304 300 53 251case control 648 9877292 206 442case control 92 130 29 63

case control 3066 12264 874 2192case control 20 10 3 17case control 46170 183963 14805 31365case control 47 100 12 35case control 32 32 5 27case control 118 120 36 82case control 164 216 82 82case control 122 134 39 83case control 560 690 50 510case control 150 150 74 76case control 77 92 10 67case control 3236 2500 1945 1291case control 1813 76248 386 1427case control 3147 3147 1340 1807case control 581 1044 127 454Cohort 8180 163600 1603 6577case control 102 82 50 52case control 20 20 3 17case control 100 100 60 40case control 3092 1521 525 2567case control 115 140 47 68

334722 11325765 79085 25533614617 9896150 4881 9736320105 1429615 74204 245600262608 1078905 56456 205851

rance database57497 350710 17748 39749 6977 9891275 1675 5302

327745 1434490 77410 250034

case control 10 16 1 9case control 10 22 3 19case control 65 52 15 50case control 1790 1835 278 1512case control 661 661 168 493case control 108132 430716 10809 97323case control 400 348 108 292case control 93 48 17 76case control 77 81 6 71case control 197 401 44 153case control 12502 24285 6078 6424case control 32 31 8 24case control 107 396 22 85case control 100 100 19 81case control 132746 510996 7025 125721case control 1131 7099 87 1044case control 338 334 128 210case control 92 130 25 67case control 3066 12264 852 2214case control 20 10 11 9case control 46170 183963 14497 31673case control 47 100 14 33case control 18 10 9 9case control 118 120 41 77case control 164 216 44 120case control 560 690 36 524

case control 150 150 73 77case control 36 20 14 22case control 77 92 25 52case control 3236 2500 1023 2213case control 3147 3147 308 2839case control 581 1044 30 551Cohort 8180 163600 1055 7125case control 102 82 12 90case control 20 20 9 11case control 9804 15288 1521 8283case control 100 100 48 52case control 3092 1521 828 2264case control 115 140 52 63

ia 337286 1362628 45343 29195513539 18369 3198 10353323747 1344259 42145 281602266250 993549 26285 239965

rance database57497 350710 15860 416376317 13989 1709 4620330969 1348639 43634 287335

case control 1264 1150 421 843case control 65 52 20 45case control 661 661 182 479case control 400 348 67 333case control 77 81 14 63case control 197 401 58 139case control 16851 48681 1419 15431case control 107 396 38 69case control 84358 322868 14166 70192case control 557 4080 192 365case control 466 177 95 371case control 400 60580 89 311case control 20 10 11 9case control 550 685 71 479case control 45 52 21 24case control 45 52 21 31case control 77 92 32 45case control 3147 3147 490 2657case control 102 82 14 88case control 20 20 5 15case control 100 100 44 56case control 373 373 56 317case control 4452 1166 179 4273case control 3092 1521 523 2569

117426 446775 18228 9920412297 11126 2008 10296105129 435649 16220 88908101982 432502 15730 86251

rance database3147 3147 490 26573239 1655 558 2681114187 445120 17670 96523

case control 1264 1150 489 775case control 661 661 315 346case control 400 348 185 215case control 338 334 193 145case control 118 120 41 77case control 164 216 93 71case control 150 150 42 108case control 77 92 47 30case control 102 82 41 61case control 115 140 84 31

3389 3293 1530 18593389 3293 1530 18593287 3211 1489 1798

case control 1790 1835 299 1491case control 46 46 8 38case control 400 348 103 297case control 77 81 10 67case control 197 401 35 162case control 338 334 102 236case control 20 10 7 13case control 118 120 52 66case control 164 216 58 106case control 150 150 42 108case control 77 92 14 63case control 581 1044 25 556case control 133 61 54 79case control 102 82 24 78case control 115 140 61 54

4308 4960 894 34144206 4878 870 3336

base studies)es)c arthritis

Controls exposed in total Controls not exposed in total country ethnic ethnicGender

7 394 Korea (Asian) 1 F & M9 316 USA (Mixed) 2 F & M16 710805836 28731040521149 19255870284687 9475170248034 893569436653 539476521217 19259418284619 9471622

87551 3915714 Denmark (Caucasian) 3 F & M26 1809 Kuwait (Arabs) 4 F & M33 628 Spain (Caucasian) 3 F & M7 74 Taiwan (Asian) 1 F & M4049 70938 Israel (Jewish: Ashk 5 F & M19 377 Netherlands (Caucasian) 3 F & M7 93 Italy (Caucasian) 3 F & M7780 549215 UK (Mixed) 2 F & M513 6586 Germany (Caucasians) 3 F & M409338 9467955 Canada (Caucasians) 3 F & M675 11590 USA (Mixed) 2 F & M1 9 Egypt (Arabs) 4 F & M9931 174032 USA (Mixed) 2 F & M9 681 Italy (Caucasians) 3 F & M19 197 Tunisia F & M3 89 India (Asian) 1 F & M64 3083 Germany (Caucasians) 3 F & M 38 1006 Germany (Caucasians) 3 F & M10470 153130 Taiwan (Asian) 1 F & M846 26731 Netherlands (Caucasians) 3 F & M 1 99 Germany (Caucasians) 3 F & M45 1476 China (Asian) 1 F & M531425 14385512410059 9481079121366 4904433100226 456259821140 341835410058 9481021121367 4904491

1 51 USA (Mixed) 2 F & M135219 3868046 Denmark (Caucasian) 3 F & M256 6387 Israel (Jewish: Ashk 5 F & M17 379 Netherlands (Caucasian) 3 F & M12333 498663 UK (Mixed) 2 F & M178 6921 Germany (Caucasian) 3 F & M110877 9766415 Canada (Caucasian) 3 F & M282 11982 USA (Mixed) 2 F & M7467 176496 USA (Mixed) 2 F & M0 216 Tunisia F & M

37 3110 Germany (Caucasians) 3 F & M7727 6053 Taiwan (Asian) 1 F & M1 99 Germany (Caucasians) 3 F & M274395 14344818111074 9774081163321 4570737147808 437309615513 197641111159 9778397163236 4566421

242 6401 Israel (Jewish: Ashk 5 F & M233 12031 USA (Mixed) 2 F & M0 100 Germany (Caucasians) 3 F & M75 4980 Taiwan (Asian) 1 F & M550 23512

98 12166 USA (Mixed) 2 F & M108954 1470083 Israel (Jewish: Ashk 5 F & M109052 1482249

183665 3819600 Denmark (Caucasian) 3 F & M301 14029 UK (Mixed) 2 F & M183966 3833629

1 51 USA (Mixed) 2 F & M3 58 India (Asian) 1 F & M318 1517 Kuwait (Arabs) 4 F & M40 621 Spain (Caucasian) 3 F & M14537 416179 UK (Mixed) 2 F & M1 45 Turkey (caucasian) 3 F & M68 212 Italy Caucasian 3 F & M31 317 Italy, Sicily (Caucasian) 3 F & M19 75 USA (Mixed) 2 M17 64 Taiwan (Asian) 1 F & M23 378 Korea (Asian) 1 F & M4013 70974 Israel (Jewish: Ashk 5 F & M35 361 Netherlands (Caucasian) 3 F & M4 96 Italy (Caucasian) 3 F & M14 25 USA (Mixed) 2 F & M23033 487963 UK (Mixed) 2 F & M210 6889 Germany (Caucasians) 3 F & M34 266 Iran (Arabs) 4 F & M 0 27 USA (Mixed) 2 F & M70 264 North italy (Caucasians) 3 F & M6 124 England (Mixed) 2 M895 11369 USA (Mixed) 2 F & M8 194 Sweden (Caucasian) 3 F & M

1 9 Egypt (Arabs) 4 F & M3 47 Turkey (Caucasian) 3 F & M17734 166229 USA (Mixed) 2 F & M1 99 Israel (Jewish: Ashk 5 F & M

4 6 Finland (Caucasian) F & M3 29 Germany (Caucasian) 3 F & M3416 34333 USA (Mixed) 2 F84 274 Michigan, USA(Mixed) 2 F & M57 63 India (Asian) 1 F & M39 177 Tunisia (Arabs) 4 F & M5 129 USA Caucasian 3 F & M 22 668 Italy (Caucasian) 3 F & M8 142 India (Asian) 1 F & M5 60 USA (Mixed) 2 F & M14 78 India (Asian) 1 F & M5 7 Prag (Caucasian) 3 F & M225 2275 USA (Mixed) 2 F & M1500 74748 USA (Mixed) 2 F1 19 India (Asian) 1 F & M357 2790 Germany (Caucasian) 3 F & M116849 1462188 Israel (Jewish: Ashk 5 F & M10732 431301 Canada (Mixed) 2 F & M61 983 Germany (Caucasian) 3 F & M12597 151003 Taiwan (Asian) 1 F & M2 80 China (Asian) 1 F & M939 14349 Netherlands (caucasian) 3 F & M10 90 Germany (Caucasians) 3 F & M107 1414 China (Asian) 1 F & M49 91 Tyrkey (Caucasian) 3 F & M

0 20 Ireland (Caucasian) 3 F & M208210 33417501600 18130192113 2908062149798 214537042315 7626921005 12962207205 3328788

0 10 Israel (Jewish: Ashk 5 F & M0 10 Israel (Jewish: Ashk 5 F & M10 42 USA (Mixed) 2 F & M5 56 India (Asian) 1 F & M212 1623 Kuwait (Arabs) 4 F & M141 520 Spain (Caucasian) 3 F & M117795 312921 UK (Mixed) 2 F & M5 41 Turkey (caucasian) 3 F & M60 288 Italy, Sicily (Caucasian) 3 F & M16 65 Taiwan (Asian) 1 F & M55 346 Korea (Asian) 1 F & M7017 41660 Israel (Jewish: Ashk 5 F & M7 24 Italy (Caucasians) 3 F & M96 300 Netherlands (Caucasian) 3 F & M14 86 Italy (Caucasian) 3 F & M91446 419550 UK (Mixed) 2 F & M987 6112 Germany (Caucasian) 3 F & M132 202 North italy (Caucasians) 3 F & M27 273 Iran (Arabs) 4 F & M 1288258 8589035 Canada (Mixed) 2 F & M32 98 England (Mixed) 2 M

2735 9529 USA (Mixed) 2 F & M1 9 Egypt (Arabs) 4 F & M52923 131040 USA (Mixed) 2 F & M3 97 Israel (Jewish: Ashk 5 F & M9 23 Germany (Caucasian) 3 F & M27 93 India (Asian) 1 F & M86 130 Tunisia F & M27 107 USA Caucasian 3 F & M 61 629 Italy (Caucasian) 3 F & M24 126 India (Asian) 1 F & M8 84 India (Asian) 1 F & M533 1967 USA (Mixed) 2 F & M15338 60910 USA (Mixed) 2 F1166 1981 Germany (Caucasian) 3 F & M106 938 Germany (Caucasian) 3 F & M25685 137915 Taiwan (Asian) 1 F & M16 66 China (Asian) 1 F & M0 20 Ireland (Caucasian) 3 F & M50 50 Germany (Caucasians) 3 F & M153 1368 China (Asian) 1 F & M33 107 Tyrkey (Caucasian) 3 F & M1605299 97204511291194 8604945314105 1115506234331 84457079774 2709361291165 8600105314134 1120346

0 10 Israel (Jewish: Ashk 5 F & M0 10 Israel (Jewish: Ashk 5 F & M11 41 USA (Mixed) 2 F & M91 1744 Kuwait (Arabs) 4 F & M142 519 Spain (Caucasian) 3 F & M45800 384916 UK (Mixed) 2 F & M36 312 Italy, Sicily (Caucasian) 3 F & M4 44 USA (Mixed) 2 F & M23 58 Taiwan (Asian) 1 F & M60 341 Korea (Asian) 1 F & M9215 15070 Israel (Jewish: Ashk 5 F & M11 20 Italy (Caucasians) 3 F & M68 328 Netherlands (Caucasian) 3 F & M10 90 Italy (Caucasian) 3 F & M23681 487315 UK (Mixed) 2 F & M304 6795 Germany (Caucasian) 3 F & M78 256 North italy (Caucasian) 3 F & M31 99 England (Mixed) 2 M2907 9357 USA (Mixed) 2 F & M3 7 Egypt (Arabs) 4 F & M50180 133783 USA (Mixed) 2 F & M13 87 Israel (Jewish: Ashk 5 F & M3 7 USA (Mixed) 2 F & M24 96 India (Asian) 1 F & M68 148 Tunisia (Arabs) 4 F & M39 651 Italy (Caucasian) 3 F & M

24 124 India (Asian) 1 F & M7 13 Turkey (Caucasian) 3 F & M38 54 India (Asian) 1 F & M240 2260 USA (Mixed) 2 F & M246 2901 Germany (Caucasian) 3 F & M29 1015 Germany (Caucasian) 3 F & M15215 148385 Taiwan (Asian) 1 F & M18 64 China (Asian) 1 F & M9 11 Ireland (Caucasian) 3 F & M2062 13226 Netherlands (Caucasian) 3 F & M31 69 Germany (Caucasians) 3 F & M275 1246 China (Asian) 1 F & M55 85 Tyrkey (Caucasian) 3 F & M

151051 12115571745 16604149306 119495383665 90988465641 2850693213 10764147838 1200793

195 955 Kuwait (Arabs) 4 F & M19 33 USA (Mixed) 2 F & M91 570 Spain (Caucasian) 3 F & M37 311 Italy, Sicily (Caucasian) 3 F & M8 73 Taiwan (Asian) 1 F & M110 291 Korea (Asian) 1 F & M1768 46909 Israel (Jewish: Ashk 5 F & M41 355 Netherlands (Caucasian) 3 F & M47499 275369 UK (Mixed) 2 F & M735 3345 USA (Mixed) 2 F & M24 153 China (Asian) 1 F & M11741 48839 USA (Mixed) 2 F & M3 7 Egypt (Arabs) 4 F & M57 628 Italy (Caucasian) 3 F & M33 65 Brazil (Mixed) 2 F33 65 Brazil (Mixed) 2 F36 56 India (Asian) 1 F & M329 2818 Germany (Caucasian) 3 F & M2 80 China (Asian) 1 F & M0 20 Ireland (Caucasian) 3 F & M33 67 Germany (Caucasian) 3 F & M34 339 Sweden (Caucasian) 3 F & M30 1136 China (Asian) 1 F & M183 1338 China (Asian) 1 F & M63041 3838221670 954861371 37427461042 371456329 2818218 148362823 382339

218 932 Kuwait (Arabs) 4 F & M205 456 Spain (Caucasian) 3 F & M89 259 Italy, Sicily (Caucasian) 3 F & M159 175 North italy (Caucasian) 3 F & M39 81 India (Asian) 1 F & M120 96 Tunisia F & M9 141 India (Asian) 1 F & M55 37 India (Asian) 1 F & M38 44 China (Asian) 1 F & M117 23 Tyrkey (Caucasian) 3 F & M1049 22441049 22441011 2200

124 1711 Kuwait (Arabs) 4 F & M5 41 Turkey (Caucasians) 3 F & M32 316 Italy, Sicily (Caucasians) 3 F & M13 68 Taiwan (Asian) 1 F & M44 357 Korea (Asian) 1 F & M236 265 North italy (Caucasian) 3 F & M0 10 Egypt (Arabs) 4 F & M36 84 India (Asian) 1 F & M67 149 Tunisia F & M9 141 India (Asian) 1 F & M16 76 India (Asian) 1 F & M11 1033 Germany (Caucasian) 3 F & M8 53 Spain (Caucasian) 3 F & M 13 69 China (Asian) 1 F & M59 91 Tyrkey (Caucasian) 3 F & M673 4464660 4395

totfemcas totmalecas totfemcon totmalecon femcasexp femcasnot malecasexp

83 114 158 243 NS NS NS182 141 194 131 10 172 16

18642 18350 2060717 1942548 NS NS NS871 964 871 964 NS NS NS311 350 311 350 NS NS NS20 57 26 55 NS NS NS8402 8449 38681 36304 798 7604 158870 37 170 226 NS NS NS44 56 44 56 NS NS NS68007 62969 295972 261023 NS NS NS531 672 NS NS NS NS NS284 364 5030857 4846435 NS NS NS1561 1505 6242 6022 NS NS NS8 12 4 6 NS NS NS23950 22220 95426 88537 NS NS NS242 318 345 345 NS NS NS83 81 117 99 NS NS NS15 62 29 63 NS NS NS1741 1406 1741 1406 NS NS NS273 308 566 478 NS NS NSNS NS NS NS NS NS NS8237 7583 14271 13306 NS NS NS48 52 27 72 NS NS NS1561 1531 763 758 NS NS NS

28 37 27 25 NS NS NS18642 18350 2060717 1942548 NS NS NS169 171 3185 3458 NS NS NS70 37 170 226 NS NS NS69040 63706 306715 204281 NS NS NS531 672 NS NS NS NS NS284 364 5030857 4846435 NS NS NS1561 1505 6242 6022 NS NS NS23950 22220 95426 88537 NS NS NS83 81 117 99 NS NS NS

1741 1406 1741 1406 NS NS NSNS NS NS NS NS NS NS48 52 27 72 NS NS NS

169 171 3185 3458 NS NS NS1561 1505 6242 6022 NS NS NS48 52 27 72 NS NS NS549 1136 3408 1647 NS NS NS

1561 1505 6242 6022 NS NS NS23064 23031 812664 766373 646 22418 1152

18642 18350 2060717 1942548 NS NS NS1853 1750 8547 5783 NS NS NS

28 37 27 25 NS NS NS7 54 7 54 NS NS NS871 964 871 964 NS NS NS311 350 311 350 NS NS NSNS NS NS NS NS NS NS17 29 17 29 NS NS NS73 127 140 140 NS NS NS162 238 162 186 NS NS NS0 94 0 94 0 0 1820 57 26 55 NS NS NS83 114 158 243 NS NS NS8402 8449 38681 36304 1125 7277 119970 37 170 226 NS NS NS44 56 44 56 NS NS NSNS NS NS NS NS NS NS67187 61956 298168 198498 NS NS NS531 672 NS NS NS NS NS155 149 147 153 38 117 1616 13 16 11 NS NS NS178 160 184 150 NS NS NS0 92 0 130 Ns NS NS1561 1505 6242 6022 NS NS NSNS NS NS NS NS NS NS8 12 4 6 NS NS NS27 48 12 38 NS NS NS23950 22220 95426 88537 NS NS NS52 48 51 48 NS NS NS

6 9 7 2 NS NS NS6 26 6 26 NS NS NS

NS NS NS NS NS NS NS48 80 54 66 NS NS NS

83 81 117 99 13 70 171 NS NS NS NS NS NS242 318 345 345 NS NS NS43 107 50 100 NS NS NS27 38 32 33 NS NS NS15 62 29 63 NS NS NSNS NS NS NS NS NS NS146 3090 295 2205 NS NS NS1813 0 76248 0 60 1753 0NS NS NS NS NS NS NS1741 1406 1741 1406 NS NS NS23064 23031 812664 766373 946 22118 101320038 20038 262914 179119 730 1938 834273 308 566 478 NS NS NSNS NS NS NS NS NS NS54 48 48 34 NS NS NS5197 4607 8158 7130 NS NS NS48 52 27 72 NS NS NS1561 1531 763 758 NS NS NS

64 51 70 70 NS NS NS11 9 11 9 NS NS NS

4 6 12 4 NS NS NS10 10 12 4 NS NS NS28 37 27 25 NS NS NS7 54 NS NS NS NS NS871 964 871 964 NS NS NS311 350 311 350 NS NS NSNS NS NS NS NS NS NS17 29 17 29 NS NS NS162 238 162 186 NS NS NS20 57 26 55 NS NS NS83 114 158 243 NS NS NS8402 8449 25318 23363 NS NS NS11 21 10 21 NS NS NS70 37 170 226 NS NS NS44 56 44 56 NS NS NS67187 61956 298168 198498 NS NS NS531 672 NS NS NS NS NS178 160 184 150 NS NS NS155 149 147 153 24 131 29284 364 5030857 4846435 NS NS NS0 92 0 130 Ns NS NS

1561 1505 6242 6022 NS NS NS8 12 4 6 NS NS NS23950 22220 95426 88537 NS NS NS52 48 51 48 NS NS NS6 26 6 26 NS NS NS48 80 54 66 NS NS NS83 81 117 99 NS NS NSNS NS NS NS NS NS NS242 318 345 345 NS NS NS43 107 50 100 NS NS NS15 62 29 63 NS NS NS146 3090 295 2205 NS NS NS1813 0 76248 0 386 1427 01741 1406 1741 1406 NS NS NS273 308 566 478 NS NS NSNS NS NS NS NS NS NS54 48 48 34 NS NS NS11 9 11 9 NS NS NS48 52 27 72 NS NS NS1561 1531 763 758 NS NS NS64 51 70 70 NS NS NS

4 6 12 4 NS NS NS10 10 12 4 NS NS NS28 37 27 25 NS NS NS871 964 871 964 NS NS NS311 350 311 350 NS NS NSNS NS NS NS NS NS NS162 238 162 186 NS NS NSNS NS NS NS NS NS NS20 26 57 55 NS NS NS83 114 158 243 NS NS NS5986 6516 12088 12197 NS NS NS11 21 10 21 NS NS NS70 37 170 226 NS NS NS44 56 44 56 NS NS NS67187 61956 298168 198498 NS NS NS531 672 NS NS NS NS NS178 160 184 150 NS NS NS0 92 0 130 NS NS NS1561 1505 6242 6022 NS NS NS8 12 4 6 NS NS NS23950 22220 95426 88537 NS NS NS52 48 51 48 NS NS NS5 13 4 6 2 3 748 80 54 66 NS NS NS83 81 117 99 22 61 22242 318 345 345 NS NS NS

43 107 50 100 NS NS NS21 15 NS NS NS NS NS15 62 29 63 NS NS NS146 3090 295 2205 NS NS NS1741 1406 1741 1406 NS NS NS273 308 566 478 NS NS NSNS NS NS NS NS NS NS54 48 48 34 NS NS NS11 9 11 9 NS NS NS5197 4607 8158 7130 NS NS NS48 52 27 72 NS NS NS1561 1531 763 758 NS NS NS64 51 70 70 NS NS NS

NS NS NS NS NS NS NS28 37 27 25 NS NS NS311 350 311 350 NS NS NS162 238 162 186 NS NS NS20 26 57 55 NS NS NS83 114 158 243 NS NS NS8402 8449 25318 23363 NS NS NS70 37 170 226 NS NS NSNS NS NS NS NS NS NS282 275 2336 1925 102 180 90208 258 78 99 NS NS NSNS NS NS NS NS NS NS8 12 4 6 NS NS NSNS NS NS NS NS NS NSNS NS NS NS NS NS NSNS NS NS NS NS NS NS15 62 29 63 NS NS NS1741 1406 1741 1406 NS NS NS54 48 34 48 NS NS NS11 9 11 9 NS NS NS48 52 27 72 NS NS NS212 161 NS NS 28 184 271891 2561 498 668 NS NS NS1561 1531 763 758 NS NS NS

NS NS NS NS NS NS NS311 350 311 350 NS NS NS162 238 162 186 NS NS NS178 160 184 150 NS NS NS48 80 54 66 NS NS NS83 81 117 99 62 21 3143 107 50 100 NS NS NS15 62 29 63 NS NS NS54 48 48 34 NS NS NS64 51 70 70 NS NS NS

NS NS 871 964 NS NS NS17 29 17 29 NS NS NS162 238 162 186 NS NS NS20 26 57 55 NS NS NS83 114 158 243 13 70 22178 160 184 150 NS NS NS8 12 4 6 NS NS NS48 80 54 66 NS NS NS83 81 117 99 NS NS NS43 107 50 100 NS NS NS15 62 29 63 NS NS NS273 308 566 478 NS NS NSNS NS NS NS NS NS NS54 48 48 34 NS NS NS64 51 70 70 NS NS NS

malecasnot femconexp femconnot maleconexp maleconnot

NS NS NS NS NS125 5 189 4 127

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS6861 1663 37018 2360 33944NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS 61066 4969791 49811 4796624NS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NS21879 19504 793160 34487 731886

NS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS76 0 0 19 75NS NS NS NS NSNS NS NS NS NS7250 2089 34592 1924 34380NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS133 19 128 15 138NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NS64 21 96 18 81NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS0 1500 74748 0 0NS NS NS NS NSNS NS NS NS NS22018 27631 785033 30655 73571819204 6299 262184 4433 174686NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS120 15 132 12 141NS 699573 5730430 588685 4257750NS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS0 15338 60910 0 0NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS6 0 4 3 3NS NS NS NS NS59 37 80 31 68NS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS185 348 1988 378 1547NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS134 NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS50 65 52 55 44NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

NS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS92 NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NSNS NS NS NS NS

PsA as Inclusionscriteria (0=no, 1=yes)

00

0000000001100000000001

0000001100

000

0100

10

00

00000000000000NS000000100001

00000000000000000000100100

010000000000000000010

100100000000000010010

0100000NS000000000010010000

0000000100010

000000000000001000100001

0000000010

000000000000010

Method

Registrered diagnosis of cardiovascular diseases. NS if it is self-reported or from medical records.Diagnosis of arterial vascular diseases in medical records

Diagnosis of MI in Danish National Patient RegisterDiagnosis of coronary heart disease in medical recordNSDiagnosis og ischemic heart disease in medical recordRegistrered diagnosis of IHD in database and by physicianSelf-reported diagnosis of myocardial infarction, if possible checked with medical recordSelf-reported diagnosis of ischemic heart disease to a physicianRegistrered diagnosis of MI in database by general practitionersRegistrered drug-treated diagnosis of MI and coronary artery disease in medical recordsRegistrered diagnosis of MI by physician and checked with medical recordsRegistrered diagnosis of IHD and drugs prescribed for this diagnosis in database based on data from health planSelf-reported diagnosis of idchemic heart diseaseDiagnosis of ishemic heart disease in health care registerSelfreported diagnosis of ischemic heart diseaseDiagnosis of ishemic heart disease. Unknown whether this was selfreported or obtained from medical records.Diagnosis of IHD self-reported to medical doctor or from medical recors Registry diagnosis of myocardial infarction in health care databaseDiagnosis of coronary heart disease in medical chartsHealth insurance database diagnose code of cardiovascular diseaseHospital discharge diagnosis of acute IHD (AMI, other acute IHD, angina pectoris) and acute MI in medical charts andSelf-reported diagnosis of myocardial infarction Diagnosis of MI in medical records

Self-reported strokeDiagnosis of stroke in Danish National Patient RegisterDiagnosis of cerebrovascular accident from medical recordSelf-reported diagnosis of cerebrovascular disease, if possible checked with medical recordsDiagnosis of stroke and TIA based on medical records of general practionersDiagnosis of stroke or TIA in patients medical records Diagnosis of cerebrovascular accident by physician and checked with medical recordsRegistrered diagnosis of cerebrovascular disease and drugs prescribed for this diagnosis in database based on data fDiagnosis in health care registerDiagnosis of cerebrovascular disease. Unknown whether this was selfreported or obtained from medical record.

Registry diagnosis ofcerebral apoplexia in health care databaseHealth insurance database diagnose code of cerebrovascular diseaseSelf-reported diagnosis of stroke

Diagnosis of peripheral vascular disease from medical recordRegistrered diagnosis of peripheral vascular disease and drugs prescribed for this diagnosis in database based on daSelf-reported diagnosis of peripheral artery occlusive disease in database based on data from health planDiagnosis of peripheral vascular disorders in Taiwans national health programme

Diagnosis of atheroschlerosis and drugs prescribed for these diagnosisDiagnosis of atheroschlerosis from medical and pharmaceutical database (peripheral vascular disease and cerebrova

Diagnosis of cardiovascular death in Danish National Patient RegisterDeaths due to cardiovascular disease (MI, stroke, peripheral vascular disease, arrythmia, left ventricular thrombus) fro

Self-reported diabetesSelf-reported diagnosis to a physician and blood samples in some patientsBlood samples (fasting blood glucose)NSDiagnosis of diabetes from general practioners database (THIN)Blood samples (fasting blood glucose +/- oral glucose tolerance test)Blood samples (fasting blood glucose, oral glucose tolerance test, cortisone-glucose tolerance test, urine glucose)Blood samples (fasting blood glucose)Blood samples (fasting blood glucose)Diagnosis of Diabetes (known whether this was self-reported or from medical records) or blood sample(fasting blood gBlood samples (fasting blood glucose)Diagnosis of Diabetes based on medical records and utilization of diabetic drugsSelf-reported diagnosis of DiabetesRelevant blood samplesBlood samples (blood glucose)Diagnosis of Diabetes in medical recordsDiagnosis of diabetes and drugs specific for diabetes in medical recordsDiagnosis of diabetes from medical chart or blood sample (glucose> 126)Self-reported diagnosis of DiabetesBlood samples (fasting glucose)Self-reported diagnosis of DiabetesDiagnosis of Diabetes and Drugs prescribed for these diagnosis based on health care claims databaseSelf-reported diagnosis of diabetesSelf-reported diagnosis of diabetesBlood samples (fasting blood glucose, insulin, c-peptid)Diagnosis of diabetes in health care registerBlood samples (fasting glucose) and self-reported diagnosis of diabetes

Blood samples (fasting glucose)Self-reported diagnosis of diabetes to a phycisianSelf-reported diagnosis of diabetesBlood samples (fasting blood glucose, oral glucose tolerance test) and/or diabetes medication based on medical recoBlood samples ( faste glucose> 6.1 mmol/l)Blood samples (fasting glucose>=6,1 mmol/L)Blood samples (glucose)Self-reported diagnosis of diabetes and/or anti-diabetic drugs, information obtained by physician using a questionaireBlood samples (fasting blood glucose)Blood samples (glucose) and urin-glucoseBlood samples and self-reported diabetesBlood samples (Blood glucose)Diagnosis of diabetes in medical recordSelf-reported diagnosis of diabetesBlood samples (Oral GTT + Steroid GTT)Registry diagnosis of diabetes in health care databaseBlood samples(HbA1c, fasting glucose, insulin) or anti-diabetic drug information in MHS diabetes registryDiagnosis of Diabetes or prescription for Diabetes medicineDiagnosis of diabetes type 2 in medical recordsHealth insurance database diagnose code of diabetesDiagnosis of diabetes in medical recordsPrescribed antidiabetic drugsPrevious physician-diagnosed diabetes and/or fasting glucose repeatedly >=126 mg/dL and/or HbA1c>= 6,5% and/orDiagnosis of Diabetes in medical recordsBlood samples (Fasting blood glucose >= 100mg/dL)Blood samples (glucose) and self-reported diabetes?

Medical history of hypertension. Unknown whether it is self-reported or from medical records.Medical history of hypertension. Unknown whether it is self-reported or from medical records.Self-reported hypertensionMedical history and systemic physical examination Physical examination (measurement of blood pressure>=140/90)Diagnosis at primary care visit or physical examination (Blood pressure >135/85 mmHg)Diagnosis of hypertension from general practioners database (THIN)Physical examination (measurement of blood pressure >= 130/85)Physical examination(blood pressure>130/85)Diagnosis of Hypertension from medical recordsPhysical examination (measurement of blood pressure >130/85)Diagnosis of hypertension based on pharmaceutical and medical databaseUnknownSelf-reported diagnosis of HypertensionPhysical examination (measurement of blood pressure>160/95)Diagnosis of hypertension in medical recordsDiagnosis of hypertension and drugs specific for hypertension in medical recordsPhysical examination (measurement of blood pressure>135/85)Diagnosis of hypertension from medical chart or physical examination (>= 140/90)Physical examination (measurement of blood pressure>=140/90) or use of antihypertensive drugs. (self-report and chSelf-reported diagnosis of hypertension

Diagnosis of Hypertension and Drugs prescribed for these diagnosis based on health careclaims databaseSelf-reported diagnosis of hypertensionDiagnosis of hypertension in health care registerPhysical examination (measurement of blood pressure>140/90) Physical examination (measurement of blood pressure)Physical examination (measurement of blood pressure > 135/85)Physical examination (Blood pressure > 135/85)NSSelf-reported diagnosis of diabetes and/or anti-diabetic drugs, information obtained by physician using a questionairePhysical examination (measurement of blood pressure >130/85)Physical examination (BP > 130/85 mmHg) and self-reportedDiagnosis of hypertension in medical record Self-reported diagnosis of HypertensionRegistry diagnosis in health care databaseDiagnosis of arterial hypertension in medical recordsHealth insurance database diagnose code of hypertensionDiagnosis of hypertension in medical recordsPhysical examination (measurement of blood pressure > 160/90) or known diagnosis of hypertension(self-reported?) Self-reported diagnosis of hypertension, intake of antihypertensive medication, repeated resting diastolic blood pressuDiagnosis of Hypertension in medical recordsPhysical examination( BP> 130/85)

Medical history og hyperlipidemia. Unknown whether this is self-reported or from medical reports.Medical history og hyperlipidemia. Unknown whether this is self-reported or from medical reports.Self-reported high cholesterolDiagnosis in medical record or blood sample (lipids)Triglyceridemia if blood sample triglycerid <1,7 mmol/LDiagnosis of hyperlipidemia from general practioners database (THIN)Physical examination(blood pressure>130/85)Blood samples (cholesterol)Diagnosis of hypertriglyceridemia in either medical records or blood sampleBlood sample (Serum lipid unspecified) Diagnosis of dyslipidaemia based on pharmaceutical and medical databaseUnknownSelf-reported diagnosis of HyperlipidemiaBlood samples (total cholesterol) Diagnosis of hyperlipidemia from medical recordDiagnosis of hyperlipoproteinaemia and drugs specific for this in medical recordsBlood samples (fasting blood triglyceride) Self-reported diagnosis of HyperlipidemiaDiagnosis of Hyperlipidaemia and Drugs prescribed for this diagnosis based on health careclaims databaseSelf-reported diagnosis of dyslipidemiaDiagnosis of Hyperlipidemia in health care registerDiagnosis of hyperlipidemia from blood samplesBlood sample (Total cholesterol)Blood sample (Triglyceride>1,7 mmol/l)Blood samples (hypertriglyceridemia >=1,7 mmol/L)Self-reported diagnosis of hyperlipidemia and/or anti-lipid drugs, information obtained by physician using a questionai

Blood samples (fasting blood triglyceride)Blood samples (total cholesterol)Blood samples (TG >= 150 mg/dL)Diagnosis of dyslipidemia in medical record Registry diagnosis of dyslipidemia in health care databaseDiagnosis of hyperlipoproteinemia in medical recordsHealth insurance database diagnose code of dyslipidemiaBlood samples (total cholesterol)Physical examination (measurement of blood pressure > 160/90) or known diagnosis of hypertension(unknown ehethPrescibed lipid-lowering drugsBlood samples (fasting LDL/HDL ratio >3)Diagnosis of Hyperlipidemia in medical recordsBlood samples (TG >= 150 mg/dL)

Physical examination (BMI>30)Self-reported obesity (BMI> 30 kg/m2)BMI>30 (unknown ehether this is selfreported or by physical examination)Physical examination (BMI > unknown)Physical examination (BMI>28)Physical examination (BMI>25)Diagnosis of obesity based on medical databaseSelf-reported height and weight (BMI>30), if possible checked with medical recordsDiagnosis of obesity (BMI>30) from medical recordSelf-reported height and weight (BMI>30)Physical examination (BMI>25)Self-reported weight (BMI>30)Self-reported diagnosis of dyslipidemiaBMI >30. Unknown whether this is selfrapported or by physical examinationBMI>30 (unknown whether this is selfreported or by physical examination)BMI>30 (unknown whether this is selfreported orby physical examination)Physical examination (BMI > 27,5 kg/m2)Registry diagnosisof obesity in health care databasePhysical examination (BMI>30)Physical examination (BMI>30) Physical examination (BMI >30)Self-reported weight and height (BMI>30)Physical examination (BMI>30)Diagnosis of obesity in medical records

Physical examination (Waist circumference >102cm in men or >88cm in women)Waist male >102 cm female >88 cm. Unknown whether this is by physical examination or self-reported.Physical examination (waist circumference > 94cm in men or >80 cm in women)Physical examination (waist circumference>102cm for men or >88 cm for women)Physical examination (waist circumference>90cm for men or >80 cm for women)Physical examination (waist cicumference female >102cm male >88cmPhysical examination (Waist circumference >102 cm in men or > 88 cm in women)Physical examination (Waist >=120 men and >=88 women)Physical examination ( waist circumference >80 in women or >90 in men according to International Association for thePhysical examination ( waist circumference >80 cm in women or >94 cm men)

ATPII (physical examination; blood pressure, waist circumference) and blood samplesATPII (physical examination; blood pressure, waist circumference) and blood samplesATPII (physical examination; blood pressure, waist circumference unknown) and blood samplesATPII (physical examination; blood pressure,BMI>28 instead of waist circumference) and blood samplesInternational Diabetes Federation 2004 ATP III (physical examination? And blood samples) IDFATP III (physical examination and blood samples) ATP III (physical examinaton and blood samples)ATPII (physical examination; blood pressure, waist circumference) and blood samplesATPIII (physical examination, blood samples and self-reported)WHO (DM type 2) based on diagnosis on medical recordsATPIII ATP III (physical examination and blood samples)IDF

Recruitment of cases A

Hospital-basedHospital-based

Population-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedPopulation-based (health insurance) Hospital-basedPopulation-based (health insurance) Hospital-basedHospital-basedHospital-basedPopulation-based (health insurance)Hospital-basedPopulation-based (health insurance)Population-basedHospital-basedHospital-based

Hospital-basedPopulation-basedPopulation-basedHospital-basedPopulation-basedHospital-basedHospital-basedPopulation-based (health insurance) Population-based (health insurance) Hospital-based

Population-based (health incurance)Population-based (health insurance)Hospital-based

Population-basedPopulation-based (health insurance)Hospital-basedPopulation-based (health insurance)

Population-based (health insurance)Population-based

Population-basedPopulation-based

Hospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-based (Health insurance)Population-basedHospital-basedHospital-basedPopulation-based (health insurance)Hospital-based

Hospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-based (Female nurses)Hospital-basedPopulation-based (health insurance)Population-basedPopulation-based (health insurance)Hospital-basedPopulation-based (health insurance)Hospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-based

Hospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-based

Population-basedHospital-basedPopulation-based (Health insurance)Hospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-based (Female nurses)Population-based (health incurance)Hospital-basedPopulation-based (health insurance)Hospital-basedHospital-basedHospital-basedHospital-basedHospital-based

Hospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedPopulation-based (Health insurance)Hospital-basedHospital-basedHospital-basedHospital-basedHospital-based

Hospital-basedHospital-basedHospital-basedHospital-basedPopulation-based (health insurance)Hospital-basedPopulation-based (health insurance)Hospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-based

Hospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedPopulation-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedPopulation-based (health insurance)Hospital-basedHospital-basedHospital-basedPopulation-basedHospital-basedHospital-based

Hospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-based

Hospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-basedHospital-based

Recruitment of cases B

Hallym Sacred heart hospital, Dept of DermatologyClinical record at Department of Dermatology in a hospital

Danish National Patient RegisterTwo hospitals in KuwaitTwo University Hospitals, North SpainDermatology outpatient departments of Taichun Veterans general Hospital and Taipei veterans General Hospital, TaiwCHS Database (Clarit Health Services database)Radboud University Nijmegen Medical Center, Department of DermatologyHospitalized in the Dermatology Department of the University of SassariGPRD (General Practitioners Research Database)Ps patients admitted for inpatient hospital treatment in 9 different departments of Dermatology in GermanyThe University of Toronto Psoriatic Arthritis ClinicPharMetrics Patients-centric DatabaseDepartment of dermatology, EgyptTwo USA healthcare claims databases (IMS health and Marketscan)20 Italian hospitalsDepartment of Dermatology in rabta Hospital, TunesiaDepartment of dermatology, Mumbai, aug 2007 to sept 2008GKV-database Saxony: outpatient database from germanyHospitalised pt with chronic plaque psoriasis in the dept of dermatology in Kiel, Germany 1996-2002Taiwan national health insurance databasePHARMO Record Linkage System (database): sample of dutch population from hospitalisation and pharmacy databasDepartment of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General Hospit

UCLA General medical dermatology clinic Danish National Patient RegisterCHS database (southern district of Clarit Health Services)Ps patients treated with biologics at Radboud University Nijmegen medical center Department of DermatologyGPRD Ps patients admitted for inpatient hospital treatmentThe University of Toronto Psoriatic Arthritis ClinicPharMetrics Patients-centric DatabaseTwo USA healthcare claims databases (IMS health and Marketscan)Department of Dermatology in rabta Hospital, Tunesia

GKV-database Saxony: outpatient database from germanyTaiwan national health insurance databaseDepartment of Dermatology of University Medical Centre Mannheim, Germany

CHS DatabasePharMetrics Patients-centric DatabaseDepartment of Dermatology of University Medical Centre Mannheim, GermanyLongitudinal helath insurance database 2000 (LHID2000), Taiwans national helath programme(NHI)

PharMetrics Patients-centric DatabaseMHS database

Danish National Patient RegisterGPRD (General Practitioners research database)

UCLA General medical dermatology clinic Department of Dermatology Two hospitals in KuwaitTwo University Hospitals, North SpainTHIN Database from UKDermatology outpatient from Department of Dermatology Antakya, TurkeyHospitalised, Umbria, ItalyDepartment of Dermatology, University of Palermo, ItalyThe section of dermatology of the Mnhatten Veterans Administration Hospital, New York, USADermatology outpatient departments of Taichun Veterans general Hospital and Taipei veterans General Hospital, TaiwHallym sacred heart hospital, dept of dermatologyCHS databasePatients treated with biologics at Radboud University Nijmegen medical center Department of dermatologyHospitalized in the Dermatology Department of the University of Sassari, ItalyDermatological Practice in ClevelandGPRDPatients admitted for inpatient hospital treatment, GermanyHospital of dermatology, IranPatients amitted to hospital for treatment of psoriasis, Minnesota, USAOutpatient clinics in 3 university hospitals, ItalyTwo teaching hospital dermatology departmentsPharMetrics Patients-centric DatabaseMembers of the Swedish Psoriasis AssociationDepartment of dermatology, EgyptOutpatient clinicTwo USA healthcare claims databases (IMS health and Marketscan)Department of Rheumatology, Israel

Department of Dermatology, Helsingfors.Inpatients treated at the Department of Dermatology, GermanyThe IWHS CohortPsoriatic patients hospitalized at the University of Michigan Hospital, USAOutpatients clinic, department of dermatology, indiaDepartment of Dermatology in rabta Hospital, TunesiaDepartment of dermatology, USA20 Italian hospitalsDepartment of Dermatology, STD and leprosy, SMHS hospital. IndiaDepartment of dermatology at Columbia University Hospital, New York, USADepartment of dermatology, Mumbai, aug 2007 to sept 2008Der Deutschen dermatologische Klinik and der deutschen Medizinischen Klinik in PragMiami VA Medical center, USANHS IIDerpartment of Dermatology and Venereology OPD of LNJPN Hospitals, New Delhi, IndiaGKV-database Saxony: outpatient database from germanyMHS databasePharmaNet - a populationbased insurance programmeHospitalised pt with chronic plaque psoriasis in the Department of Dermatology in Kiel, Germany 1996-2002Taiwan national health insurance databaseTwo regional hospitals in China, Hong KongPHARMO linkage system (databases)Department of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General HospitDepartment of dermatology, TyrkeyOutpatient Department of Dermatology

Department of Dermatology, Tel-Aviv Sourasky Medical Centre, Israel Referred to rheumatology clinicUCLA General medical dermatology clinic Department of Dermatology Two hospitals in KuwaitTwo University Hospitals, North SpainTHIN Database from UKDermatology outpatient from Department of Dermatology Antakya, TurkeyDepartment of Dermatology, University of Palermo, ItalyDermatology outpatient departments of Taichun Veterans general Hospital and Taipei veterans General Hospital, TaiwHallym sacred heart hospital, Department of DermatologyCHS databaseDepartment of Dermatology, Catholic University of the Sacred Heart, ItalyPs patients treated with biologics at Radboud University Nijmegen medical center Department of dermatologyHospitalized in the Dermatology Department of the University of SassariGPRD Ps patients admitted for inpatient hospital treatmentOutpatient clinics in 3 university hospitals, ItalyHospital of dermatology, IranThe University of Toronto Psoriatic Arthritis ClinicTwo teaching hospital dermatology departments

PharMetrics Patients-centric DatabaseDepartment of dermatology, EgyptTwo USA healthcare claims databases (IMS health and Marketscan)Department of Rheumatology, IsraelInpatients treated at the Department of Dermatology, GermanyOutpatients clinic, department of dermatology, indiaDepartment of Dermatology in rabta Hospital, TunesiaDepartment of dermatology, USA20 Italian hospitalsDepartment of Dermatology, STD and leprosy, SMHS hospital, IndiaDepartment of dermatology, Mumbai, aug 2007 to sept 2008Miami VA Medical centerNHS IIGKV-database Saxony: outpatient database from germanyHospitalised pt with chronic plaque psoriasis in the dept of dermatology in Kiel, Germany 1996-2002Taiwan national health insurance databaseTwo regional hospitals in China, Hong KongOutpatient Department of DermatologyDepartment of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General HospitDepartment of dermatology, Tyrkey

Department of Dermatology, Tel-Aviv Sourasky Medical Centre, IsraelReferral rheumatology clinicUCLA General medical dermatology clinic Two hospitals in KuwaitTwo University Hospitals, North SpainTHIN Database from UKDepartment of Dermatology, University of Palermo, ItalyDepartment of Dermatology, New York University, USADermatology outpatient departments of Taichun Veterans general Hospital and Taipei veterans General Hospital, TaiwHallym sacred heart hospital, dept of dermatologyCHS databaseDepartment of Dermatology, Catholic University of the Sacred Heart, ItalyPs patients treated with biologics at Radboud University Nijmegen medical center Department of dermatologyHospitalized in the Department of Dermatology, University of SassariGPRD Ps patients admitted for inpatient hospital treatmentOutpatient clinics in 3 university hospitalsTwo teaching hospital dermatology departmentsPharMetrics Patients-centric DatabaseDepartment of dermatology, EgyptTwo USA healthcare claims databases (IMS health and Marketscan)Department of Rheumatology, IsraelDepartment of Dermatology, University of Michigan, USAOutpatients clinic, department of dermatology, indiaDepartment of Dermatology in rabta Hospital, Tunesia20 Italian hospitals

Department of Dermatology, STD and leprosy, SMHS hospital. IndiaDermatology outpatient clinic of celal bayer universityDepartment of dermatology, Mumbai, aug 2007 to sept 2008Miami VA Medical centerGKV-database Saxony: outpatient database from germanyHospitalised pt with chronic plaque psoriasis in the dept of dermatology in Kiel, Germany 1996-2002Taiwan national health insurance databaseTwo regional hospitals in China, Hong KongOutpatient Department of DermatologyPHARMO linkage system(databases)Department of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General HospitDepartment of dermatology, Tyrkey

Two hospitals in KuwaitUCLA General medical dermatology clinic Two University Hospitals, North SpainDepartment of Dermatology, University of Palermo, ItalyDermatology outpatient departments of Taichun Veterans general Hospital and Taipei veterans General Hospital, TaiwHallym sacred heart hospital, Department of DermatologyCHS databasePs patients treated with biologics at Radboud University Nijmegen medical center Department of dermatologyGPRD UPIThe first affiliated hospital of Anhui Medical University, dermatological clinicsMEPS and MCBS databaseDepartment of dermatology, Egypt20 Italian hospitalsUNIFESP/EPM Dermatology Outpatient Clinic, BrazilUNIFESP/EPM Dermatology Outpatient Clinic, BrazilDepartment of dermatology, Mumbai, aug 2007 to sept 2008GKV-database Saxony: outpatient database from germanyRheumatology clinics in ChinaOutpatient Department of DermatologyDepartment of Dermatology of University Medical Centre Mannheim, GermanyPopulation in Stockholm areaPatients admitted to the outpatients from hospitals in ChinaMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General Hospit

Two hospitals in KuwaitTwo University Hospitals, North SpainDepartment of Dermatology, University of Palermo, ItalyOutpatient clinics in 3 university hospitalsOutpatients clinic, department of dermatology, indiaDepartment of Dermatology in rabta Hospital, TunesiaDepartment of Dermatology, STD and leprosy, SMHS hospital, IndiaDepartment of dermatology, Mumbai, aug 2007 to sept 2008Two regional hospitals in China, Hong KongDepartment of dermatology, Tyrkey

Two hospitals in KuwaitDermatology outpatients from Department of Dermatology, Antakya, TurkeyDepartment of Dermatology, University of Palermo, ItalyDermatology outpatient departments of Taichun Veterans general Hospital and Taipei veterans General Hospital, TaiwHallym sacred heart hospital, dept of dermatologyOutpatient clinics in 3 university hospitalsDepartment of dermatology, EgyptOutpatients clinic, department of dermatology, indiaDepartment of Dermatology in rabta Hospital, TunesiaDepartment of Dermatology, STD and leprosy, SMHS hospital, IndiaDepartment of dermatology, Mumbai, aug 2007 to sept 2008Hospitalised pt with chronic plaque psoriasis in the dept of dermatology in Kiel, Germany 1996-2002Department of dermatology, SpainTwo regional hospitals in China, Hong KongDepartment of dermatology, Tyrkey

Recruitment of controls

Non-ps subjects who had visited the hospitals Health Promotion CentreClinical record at Department of Dermatology in a hospital

Danish National Patient RegisterHospital-basedNon-psoriatics in two University Hospitals, North SpainNon-ps patients from health examine clinics TaiwanCHS Database (Clarit Health Services database)Patients with dermatological disease other than psoriasis from the same hospitalHospitalized in the Dermatology Department of the University of SassariGPRD (General Practitioners Research Database)BGS98 national health survey germanyCanadian Community Health Survey (CCHS)PharMetrics database?Department of dermatology, Egypt, without psoriasisTwo USA healthcare claims databases (IMS health and Marketscan)20Italian hospitalsFrom Tunis populationNon psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008GKV-database SaxonyHospitalised pt due to surgical treatment for stage 1 melanoma during the same period in timeTaiwan national health insurance databasePHARMO Record linkage system - populationNon-psoriatics from Department of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General Hospit

UCLA General medical dermatology clinic, patients without psoriasisDanish National Patient RegisterCHS database ; pt who underwent hernioplasty or appendectomySame hospital, patients with dermatological disease other than psoriasisGPRDBGS98 national health survey germanyCanadian Community Health Survey (CCHS)PharMetrics Patients-centric DatabaseTwo USA healthcare claims databases (IMS health and Marketscan)From Tunis population

GKV-database SaxonyTaiwan national health insurance databaseNon-psoriatics from Department of Dermatology of University Medical Centre Mannheim, Germany

CHS DatabasePharMetrics database?Non-psoriatics from Department of Dermatology of University Medical Centre Mannheim, GermanyLHID2000

PharMetrics database?MHS database

Danish National Patient RegisterGPRD (General Practitioners Research Database)

UCLA General medical dermatology clinic, patients without psoriasisNSHospital-basedNon-psoriatics in two University Hospitals, North SpainTHIN Database from UKDermatology outpatienst (not psoriasis) from Department of Dermatology Antakya, TurkeyNSNon-psoriatics from the Department of Dermatology, University of Palermo Same hospital, pt hospitalized for elective inguinal herniorrhaphy or hemorrhoidectomyHealth examine clinics TaiwanNon-ps subjects who had visited the hospitals health promotion centreCHS databasesame hospital, patients with dermatological disease other than psoriasisHospitalized in the Dermatology Department of the University of Sassari, ItalyEzcema patients at the same practice, ClevelandGPRDBGS98 national health survey, GermanyNSPatients admitted for tretament of other skin diseases tha psoriasis at the Hospital in Minnosota, USAOut patients clinics in 3 university hospitals, ItalyTwo teaching hospital dermatology departmentsPharMetrics databaseSiblings to the members of the swedish psoriasis associationDepartment of dermatology, Egypt, without psoriasisHealthy subject from outpatient clinicTwo USA healthcare claims databases (IMS health and Marketscan)Outpatient department, Tel Aviv Medical center going for routine check up

Patients with Besnier (atopic dermatitis) in the same hospitalDepartment of Radiology, GermanyThe IWHS CohortNon-psoriatic hospital patients fom Michigan hospital, USAOutpatient without psoriasis clinic, department of dermatology, indiaFrom Tunis populationHealthy subjects from Philidelphia, USA20 Italian hospitalsPatients with insignificant complaints + attendants of patients + staff members of the hospitalNon-psoriatics at Department of dermatology at Columbia University Hospital, New York, USANon psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008Lues patients from the same placeMiami VA Medical centre, USANHS II Department of Dermatology and Venereology OPD of LNJPN Hospitals, New Delhi, IndiaGKV-database SaxonyMHS databasePharmaNetHospitalised pt due to surgical treatment for stage 1 melanoma during the same period in timeTaiwan national health insurance databaseHealthy hospital staff, ChinaPHARMO linkage system - populationNon-psoriatics from Department of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General HospitNSOutpatient department of Dermatology

Hospital staffHospital staffUCLA General medical dermatology clinic, patients without psoriasisNSHospital-basedNon-psoriatics in two University Hospitals, North SpainTHIN Database from UKDermatology outpatienst (not psoriasis) from Department of Dermatology Antakya, TurkeyNon-psoriatics from the Department of Dermatology, University of Palermo Health examine clinics TaiwanNon-ps subjects who had visited the hospitals health promotion centreCHS databaseHealthy controles from unknown placeSame hospital, patients with dermatological disease other than psoriasisHospitalized in the Dermatology Department of the University of SassariGPRDBGS98 national health survey GermanyOut patients clinics in 3 university hospitals, ItalyNSCanadian Community Health Survey (CCHS)Two teaching hospital dermatology departments

PharMetrics Patients-centric DatabaseDepartment of dermatology, Egypt, without psoriasisTwo USA healthcare claims databases (IMS health and Marketscan)Outpatient department, Tel Aviv Medical center going for routine check upDepartment of Radiology, GermanyOutpatient without psoriasis clinic, department of dermatology, indiaFrom Tunis populationHealthy subjects from Philidelphia, USA20 Italian hospitalsPatients with insignificant complaints + attendants of patients + staff members of the hospitalNon psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008Miami VA Medical centreNHS II GKV-database SaxonyHospitalised pt due to surgical treatment for stage 1 melanoma during the same period in timeTaiwan national health insurance databaseHealthy hospital staff, ChinaOutpatient department of DermatologyNon-psoriatics from Department of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General HospitNS

Hospital staffHospital staffUCLA General medical dermatology clinic, patients without psoriasisHospital-basedNon-psoriatics in two University Hospitals, North SpainTHIN Database from UKNon-psoriatics from the Department of Dermatology, University of Palermo Department of Dermatology, New York University, USAHealth examine clinics TaiwanNon-ps subjects who had visited the hospitals health promotion centreCHS databaseHealthy controles from unknown placeSame hospital, patients with dermatological disease other than psoriasisHospitalized in the Department of Dermatology, University of SassariGPRDBGS98 national health survey GermanyOut patients clinics in 3 university hospitalsTwo teaching hospital dermatology departmentsPharMetrics database?Department of dermatology, Egypt, without psoriasisTwo USA healthcare claims databases (IMS health and Marketscan)Outpatient department, Tel Aviv Medical center going for routine check upUnknownOutpatient without psoriasis clinic, department of dermatology, indiaFrom Tunis population20 Italian hospitals

Patients with insignificant complaints + attendants of patients + staff members of the hospitalNSNon psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008Miami VA Medical centreGKV-database SaxonyHospitalised pt due to surgical treatment for stage 1 melanoma during the same period in timeTaiwan national health insurance databaseHealthy hospital staff ChinaOutpatient department of DermatologyPHARMO linkage system - populationNon-psoriatics from Department of Dermatology of University Medical Centre Mannheim, GermanyMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General HospitNS

Hospital-basedUCLA General medical dermatology clinic, patients without psoriasisNon-psoriatics in two University Hospitals, North SpainDepartment of Dermatology, University of Palermo - nonpsoriasticsHealth examine clinics TaiwanNon-ps subjects who had visited the hospitals health promotion centreCHS databaseSame hospital, patients with dermatological disease other than psoriasisGPRDNPF+dermatology clinicsThe first affiliated hospital of Anhui Medical University, dermatological clinicsMEPS and MCBS databaseDepartment of dermatology, Egypt, without psoriasis20 Italian hospitalsHealthy controls from?Healthy controls from?Non psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008GKV-database SaxonyStaff from hospitals in ChinaOutpatient Department of DermatologyNon-psoriatics from Department of Dermatology of University Medical Centre Mannheim, GermanySwedish Population RegistryHealth examination centre and outpatient department, ChinaMedical Records Section of Affiliated Union Hospital, Tongij Hospital, Wuhan Iron and Steel Company General Hospit

Hospital-basedNon-psoriatics in two University Hospitals, North SpainDepartment of Dermatology, University of Palermo - nonpsoriasticsOut patients clinics in 3 university hospitalsOutpatient without psoriasis clinic, department of dermatology, indiaFrom Tunis populationPatients with insignificant complaints + attendants of patients + staff members of the hospitalNon psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008Healthy hospital staff ChinaNS

Hospital-basedDermatology outpatient (not psoriasis) from Department of Dermatology, Antakya, TurkeyDepartment of Dermatology, University of Palermo - nonpsoriasticsHealth examine clinics TaiwanNon-ps subjects who had visited the hospitals health promotion centreOut patients clinics in 3 university hospitalsDepartment of dermatology, Egypt, without psoriasisOutpatient without psoriasis clinic, department of dermatology, indiaFrom Tunis populationPatients with insignificant complaints + attendants of patients + staff members of the hospitalNon psoriatics from Department of dermatology, Mumbai, aug 2007 to sept 2008Hospitalised pt due to surgical treatment for stage 1 melanoma during the same period in timeDepartment of dermatology, Spain. Without psoriasisHealthy hospital staff ChinaNS

ps-type Psoriasis severity Mean PASI % Mild psoriasis

Plaque (+others) Mild to severe NS NSNS NS NS NS

NS Mild to severe NS 93vulgaris Mild to severe NS 92,79 mild to moderateNS Mild to severe NS NSNS NS NS NSNS NS NS NSNS Severe: "High need psoriasis" de NS NS"Diffuse" and 5 wSevere NS 0NS Mild and severe NS NS

Mild to severe26 NSPsA NS 5.5 NSPsA NS NS NSNS NS 8.92 NSNS Mild and severe NS NSplaque NS NS NSVulgaris (+othersMild to severe 5.15 68.3Plaque Mild to severe 4.61 87.01NS NS NS NSPlaque NS NS NSNS NS NS NSNS NS NS NSPlaque (+others) NS 16.7 NSNS Mild to severe NS NS

NS NS 4,6 (median) NSNS Mild to severe NS 93NS NS NS NSNS High need psoriasis pt treated witNS NSNS Mild and severe NS NSplaque (+other) Mild to severe 26 NSPsA NS 5.5 NSPsA NS NS NSNS Mild and severe NS NSVulgaris (+othersMild to severe 5.15 68.3

plaque (+other)

NS NS NS NSNS NS NS NSPlaque (+others) NS 16.7 NS

NS NS NS NSPsA NS NS NSPlaque (+others) NS 16.7 NSNS NS NS NS

PsA NS NS NSNS NS NS NS

NS Mild to severe NS 93%NS Severe NS 0

NS NS 4,6 (median) NSVulgaris (+other) NS NS NSvulgaris Mild to severe NS 92,79 mild to moderateNS Mild to severe NS NSNS Mild to severe NS 94Vulgaris NS 6.1 NSNS NS NS NSPlaque Mild to severe 13.21 NSNS NS NS NSNS NS NS NSPlaque (+other) Mild to severe NS NSNS NS NS NSNS High need psoriasis pt treated witNS NSNS Severe NS 0NS NS NS NSNS Mild and severe NS NS

Mild to severe26 NSPlaque (+ others NS NS NSNS NS NS NSPlaque(+others) Mild to severe NS NSPlaque (+others) NS NS NSPsA NS NS NSNS Mostly mild NS NSNS NS 8.92 NSNS NS NS NSNS Mild and severe NS NSPsA NS 2.7 NS

Plaque (+others)

NS NS NS NSPlaque NS NS NSNS NS NS NSNS NS NS NSPlaque Mild to severe 6.2 69.4Vulgaris (+othersMild to severe 5.15 68.3NS Mild to moderate NS NSPlaque NS NS NSPlaque Mild to severe NS NSNS NS NS NSPlaque Mild to severe 4.61 87.01NS NS NS NSNS NS NS NSNS NS NS NSNS Mild to severe NS NSNS NS NS NSNS NS NS NSPsA or PsO NS NS NSPlaque NS NS NSNS NS NS NSPsA NS NS NSNS Mild to severe NS NSPlaque (+others) NS 16.7 NSNS Mild to severe NS NSPlaque Mild to severe NS 66,1 (Mild to moderate)NS Mild to severe NS NS

NS Mild to severe NS NSNS Mild to severe NS NSNS NS 4,6 (median) NSNS NS NS NSvulgaris Mild to severe NS 92,79 mild to moderateNS Mild to severe NS NSNS Mild to severe NS 94Vulgaris NS 6.1 NSPlaque Mild to severe 13.21 NSNS NS NS NSPlaque (+others) Mild to severe NS NSNS NS NS NSPlaque NS 17.9 NSNS High need psoriasis pt treated witNS NSNS Severe NS 0NS Mild and severe NS NS

Mild to severe26 NSPlaque(+others) Mild to severe NS NSPlaque (+ others NS NS NSPsA NS 5.5 NSPlaque (+others) NS NS NS

Plaque (+others)

PsA NS NS NSNS NS 8.92 NSNS Mild and severe NS NSPsA NS 2.7 NSPlaque NS NS NSPlaque Mild to severe 6.2 69.4Vulgaris (+othersMild to severe 5.15 68.3NS Mild to moderate NS NSPlaque NS NS NSPlaque Mild to severe NS NSPlaque Mild to severe 4.61 87.01NS NS NS NSNS NS NS NSNS NS NS NSPlaque NS NS NSNS NS NS NSPsA NS NS NSNS Mild to severe NS NSPlaque (+others) NS 16.7 NSNS Mild to severe NS NSPlaque Mild to severe NS 66,1 (Mild to moderate)

NS Mild to severe NS NSNS Mild to severe NS NSNS NS 4,6 (median) NSvulgaris Mild to severe NS 92,79 mild to moderateNS Mild to severe NS NSNS Mild to severe NS 94Plaque Mild to severe 13.21 NSNS NS NS NSNS NS NS NSPlaque (+others) Mild to severe NS NSNS NS NS NSPlaque NS 17.9 NSNS High need psoriasis pt treated witNS NSNS Severe NS 0NS Mild and severe NS NS

Mild to severe26 NSPlaque(+others) Mild to severe NS NSPlaque (+others) NS NS NSPsA NS NS NSNS NS 8.92 NSNS Mild and severe NS NSPsA NS 2.7 NSNS NS NS NSPlaque Mild to severe 6.2 69.4Vulgaris (+othersMild to severe 5.15 68.3Plaque NS NS NS

Plaque (+others)

Plaque Mild to severe NS NSNS Mild to severe NS NSPlaque Mild to severe 4.61 87.01NS NS NS NSNS NS NS NSPlaque NS NS NSNS NS NS NSPsA NS NS NSNS Mild to severe NS NSNS Mild to severe NS NSPlaque (+others) NS 16.7 NSNS Mild to severe NS NSPlaque Mild to severe NS 66,1 (Mild to moderate)

Vulgaris Mild to severe NS 92,79 mild to moderateNS NS 4,6 (median) NSNS Mild to severe NS NSPlaque Mild to severe 13.21 NSNS NS NS NSPlaque (+others) Mild to severe NS NSNS NS NS NSNS High need psoriasis pt treated witNS NSNS Mild and severe NS NSNS NS NS NSVulgaris NS NS NSNS NS NS NSNS NS 8.92 NSPlaque NS NS NSNS NS 2.2 NSNS NS 3.2 NSPlaque Mild to severe 4.61 87.01NS NS NS NSPsA NS NS NSNS Mild to severe NS NSPlaque (+others) NS 16.7 NSNS NS 3.5 NSVulgaris (+othersMild to severe NS 37.62NS Mild to severe NS NS

Vulgaris Mild to severe NS 92,79 mild to moderateNS Mild to severe NS NSPlaque Mild to severe 13.21 NSPlaque(+others) Mild to severe NS NSPlaque Mild to severe 6.2 69.4Vulgaris (+othersMild to severe 5.15 68.3Plaque Mild to severe NS NSPlaque Mild to severe 4.61 87.01PsA NS NS NSPlaque Mild to severe NS 66,1 (Mild to moderate)

Vulgaris Mild to severe NS 92,79 mild to moderateVulgaris NS 6.1 NSPlaque Mild to severe 13.21 NSNS NS NS NSPlaque (+others) Mild to severe NS NSPlaque(+others) Mild to severe NS NSNS NS 8.92 NSPlaque Mild to severe 6.2 69.4Vulgaris (+othersMild to severe 5.15 68.3Plaque Mild to severe NS NSPlaque Mild to severe 4.61 87.01Plaque NS NS NSNS Mild to severe 19.25 NSPsA NS NS NSPlaque Mild to severe NS 66,1 (Mild to moderate)

% Moderate psoriasis % Severe psoriasis Mean duration of psoriasis (yMean age cases

NS NS NS 45.04NS NS NS NS

0 7 NS 47.0592,79 mild to moderate 7.21 14.5 52.3NS NS NS 47.4NS NS NS 57.39NS NS NS 51NS NS NS 48.50 100 NS NSNS NS NS 48.05NS NS NS 49.7NS NS NS NSNS NS NS NSNS NS 12.45 45.55NS NS NS 47,1 - 54,9NS NS NS NS21.3 10.4 NS 46.2812,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS 57.1NS NS NS NSNS NS NS 47.43NS NS NS 48.9NS NS 19.1 51.8NS NS NS 43,6 - 46,3

Mean age total 49.664

NS NS NS 50.20 7 NS 46,9 - 47,2NS NS NS 47.7NS NS NS 48.5NS NS NS 45,1 - 52,2NS NS NS 49.7NS NS NS NSNS NS NS NSNS NS NS 47,1 - 54,921.3 10.4 NS 46.28

NS NS NS 57.1NS NS NS 47.43NS NS 19.1 51.8


NS NS NS 47.7NS NS NS NSNS NS 19.1 51.8NS NS NS 48.6

Mean age 49.36666667

NS NS NS NSNS NS NS 41.28

0 7 NS 46,9 - 47,20 100 NS 52.2

NS NS NS 50.2NS NS NS NS92,79 mild to moderate 7.21 14.5 52.3NS NS NS 47.40 6 NS 46.03NS NS 11 39.5NS NS NS NSNS NS NS 47.6NS NS NS NSNS NS NS 57.39NS NS NS 45.04NS NS NS 51NS NS NS 48.50 100 NS NSNS NS NS NSNS NS NS 45,1 - 52,2NS NS NS 49.7NS NS NS 41.06NS NS NS NSNS NS NS 62.1NS NS 19.9 46.7NS NS NS NSNS NS 21 40.2NS NS 12.45 45.55NS NS NS 40.4NS NS NS 47,1 - 54,9NS NS NS 50

NS NS NS 54NS NS NS 49NS NS NS NSNS NS NS 4716.9 13.5 NS 46.4321.3 10.4 NS 46.28NS NS NS NS ( median 44,5)NS NS NS NSNS NS NS 37.34NS NS NS NS12,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS 24.5NS NS NS 67.9NS NS NS 36.4NS NS NS 29.7NS NS NS 57.1NS NS NS 41.28NS NS NS 50NS NS NS NSNS NS NS 47.43NS NS NS 48.7NS NS NS 48.9NS NS 19.1 51.8NS NS NS 43,6 - 46,366,1 (Mild to moderate) 33.9 11.4 45.4NS NS NS 41.8


NS NS NS 48.6NS NS NS 47.18NS NS NS 50.2NS NS NS NS92,79 mild to moderate 7.21 14.5 52.3NS NS NS 47.40 6 NS 46.03NS NS 11 39.5NS NS NS 47.6NS NS NS 57.39NS NS NS 45.04NS NS NS 42.7NS NS 12.6 36.2NS NS NS 48.50 100 NS NSNS NS NS 45,1 - 52,2NS NS NS 49.7NS NS NS 62.1NS NS NS 41.06NS NS NS NSNS NS 19.9 46.7

NS NS NS NSNS NS 12.45 45.55NS NS NS 47,1 - 54,9NS NS NS 50NS NS NS 4916.9 13.5 NS 46.4321.3 10.4 NS 46.28NS NS NS NS ( median 44,5)NS NS NS NSNS NS NS 37.3412,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS 67.9NS NS NS 36.4NS NS NS 57.1NS NS NS NSNS NS NS 47.43NS NS NS 48.7NS NS NS 41.8NS NS 19.1 51.8NS NS NS 43,6 - 46,366,1 (Mild to moderate) 33.9 11.4 45.4


NS NS NS 48.6NS NS NS 47.18NS NS NS 50.292,79 mild to moderate 7.21 14.5 52.3NS NS NS 47.40 6 NS 46.03NS NS NS 47.6NS NS NS NSNS NS NS 57.39NS NS NS 45.04NS NS NS 55.8NS NS 12.6 36.2NS NS NS 48.50 100 NS NSNS NS NS 45,1 - 52,2NS NS NS 49.7NS NS NS 62.1NS NS 19.9 46.7NS NS NS NSNS NS 12.45 45.55NS NS NS 47,1 - 54,9NS NS NS 50NS NS NS 36.716.9 13.5 NS 46.4321.3 10.4 NS 46.28NS NS NS NS

NS NS NS 37.34NS NS NS NS12,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS 67.9NS NS NS 57.1NS NS NS NSNS NS NS 47.43NS NS NS 48.7NS NS NS 41.8NS NS NS 48.9NS NS 19.1 51.8NS NS NS 43,6 - 46,366,1 (Mild to moderate) 33.9 11.4 45.4


92,79 mild to moderate 7.21 14.5 52.3NS NS NS 50.2NS NS NS 47.4NS NS NS 47.6NS NS NS 57.39NS NS NS NSNS NS NS 42.7NS NS NS 48.5NS NS NS 45,1 - 52,2NS NS NS 49.8NS NS NS 25.86NS NS NS NSNS NS 12.45 45.55NS NS NS NSNS NS 24.8 60.5NS NS 21.8 61.412,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS 57.1NS NS NS 48.7NS NS NS 41.8NS NS 19.1 51.8NS NS NS 4629.94 32.43 NS 36.54NS NS NS 43,6 - 46,3


92,79 mild to moderate 7.21 14.5 52.3NS NS NS 47.4NS NS NS 47.6NS NS NS 62.116.9 13.5 NS 46.4321.3 10.4 NS 46.28NS NS NS 37.3412,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS 48.766,1 (Mild to moderate) 33.9 11.4 45.4


92,79 mild to moderate 7.21 14.5 52.3NS NS 11 39.5NS NS NS 47.6NS NS NS 57.39NS NS NS NSNS NS NS 62.1NS NS 12.45 45.5516.9 13.5 NS 46.4321.3 10.4 NS 46.28NS NS NS 37.3412,99 (Moderat to severe12,99 (Moderat to se 7.3 46.51NS NS NS NSNS 100 18,64 for men & 18,72 for wo46,87 for men & 4NS NS NS 48.766,1 (Mild to moderate) 33.9 11.4 45.4


Mean age controls Mean BMI cases % Men cases % Women cases % Men controls

46.89 NS 57.87 42.13 60.60NS NS 43.65 56.35 40.31

NS NS 49.61 50.39 48.5252.7 NS 53.85 48.66 52.5347.4 NS 52.95 47.05 52.9555.63 24 74.03 25.97 67.9033.8 NS 50.14 49.86 48.4151.2 28.5 34.58 65.42 57.07NS NS 56.00 44.00 56.0045.72 26.16 48.08 51.92 46.86NS NS 59.42 46.95 NSNS NS 56.17 43.83 49.07NS NS 49.09 50.91 49.1041.8 28.53 60.00 40.00 60.0047,1 - 54,9 NS 48.13 51.87 48.13NS NS 56.79 43.21 50.0048.64 NS 49.39 50.61 45.8343.24 NS 80.52 19.48 68.4857.1 NS 44.68 55.32 44.68NS NS 53.01 46.99 45.7947.47 NS NS (is the % givNS (is the % given NS (is the % give48.1 NS 47.93 52.07 48.2551.9 30.1 52.00 48.00 72.0043.6 NS 49.51 50.49 49.8447.73571429 Mean gender distri56.29 49.15 53.07

51.9 27.73 56.92 43.08 48.0847.3 NS 49.61 50.39 48.5247 NS 50.29 49.71 52.0551.2 28.5 34.58 65.42 57.0746,1 - 49,7 NS 47.99 52.01 39.98NS NS 59.42 46.95 NSNS NS 56.17 43.83 49.07NS NS 49.09 50.91 49.1047,1 - 54,9 NS 48.13 51.87 48.1348.64 NS 49.39 50.61 45.83

57.1 NS 44.68 55.32 44.6847.47 NS NS (is the % givNS (is the % given NS (is the % give51.9 30.1 52.00 48.00 72.0050.31375 Mean gender distri49.86 50.68 50.41

47 NS 50.29 49.71 52.05NS NS 49.09 50.91 49.1051.9 30.1 52.00 48.00 72.00NS NS 67.40 32.60 67.4049.45 Mean gender distri54.70 45.30 60.14

NS NS 49.09 50.91 49.10NS NS 49.96 50.04 48.53

Mean gender distri49.53 50.47 48.82

47.3 NS 49.61 50.39 48.52NS NS 48.57 51.43 40.36

Mean gender distri49.09 50.91 44.44

51.9 27.73 56.92 43.08 48.08NS NS 88.52 11.48 88.5252.7 NS 53.85 48.66 52.5347.4 NS 52.95 47.05 52.9548.4 26.46 49.00 51.00 44.0039.8 26.5 63.04 36.96 63.04NS NS 63.50 36.50 50.0047.6 25.8 59.50 40.50 53.45NS NS 100.00 0.00 100.0055.63 24 74.03 25.97 67.9046.89 NS 57.87 42.13 60.6033.8 NS 50.14 49.86 48.4151.2 28.5 34.58 65.42 57.07NS NS 56.00 44.00 56.00NS NS NS NS NS46,1 - 49,7 NS 46.67 50.61 38.85NS NS 59.42 46.95 NS39.74 26.25 49.01 50.99 51.00NS NS 44.83 55.17 40.7463.8 27.7 47.34 52.66 44.9152.7 NS 100.00 0.00 100.00NS NS 49.09 50.91 49.1041.3 NS NS NS NS41.8 28.53 60.00 40.00 60.0040.1 28.7 64.00 36.00 76.0047,1 - 54,9 NS 48.13 51.87 48.1334.9 27.7 102.13 110.64 48.00

20 NS 60.00 40.00 20.0049.3 28.9 81.25 18.75 81.25NS NS 0.00 100.00 0.0048 NS NS NS NS45.89 NS 67.80 40.68 55.0048.64 NS 49.39 50.61 45.83NS ( median 49) NS ( median 29.5 60.00 40.00 53.00NS NS 56.79 43.21 50.0036.33 23.94 71.33 28.67 66.67NS NS 58.46 41.54 50.7743.24 NS 80.52 19.48 68.4821.75 NS NS NS NS65.1 NS 95.49 4.51 88.2036.2 24.4 0.00 100.00 0.0029.75 NS NS NS NS57.1 NS 44.68 55.32 44.68NS NS 49.96 50.04 48.5353 NS 49.67 49.67 40.52NS NS 53.01 46.99 45.7947.47 NS NS (is the % givNS (is the % given NS (is the % give48.1 25.4 47.06 52.94 41.4648.1 NS 46.99 53.01 46.6451.9 30.1 52.00 48.00 72.0043.6 NS 49.51 50.49 49.8443.4 28.73 44.30 55.70 50.0041.7 NS 45.00 55.00 45.0045.12861111 Mean gender distri57.31 45.38 53.75

0.00 0.00 0.0041.69 NS 60.00 40.00 25.0041.69 NS 45.45 45.45 25.0051.9 27.73 56.92 43.08 48.08NS NS 88.52 11.48 NS52.7 NS 53.85 48.66 52.5347.4 NS 52.95 47.05 52.9548.4 26.46 49.00 51.00 44.0039.8 26.5 63.04 36.96 63.0447.6 25.8 59.50 40.50 53.4555.63 24 74.03 25.97 67.9046.89 NS 57.87 42.13 60.6051 NS 50.14 49.86 47.9941 25 65.63 34.38 67.7451.2 28.5 34.58 65.42 57.07NS NS 56.00 44.00 56.0046,1 - 49,7 NS 46.67 50.61 38.85NS NS 59.42 46.95 NS63.8 27.7 47.34 52.66 44.9139.74 26.25 49.01 50.99 51.00NS NS 56.17 43.83 49.0752.7 NS 100.00 0.00 100.00

NS NS 49.09 50.91 49.1041.8 28.53 60.00 40.00 60.0047,1 - 54,9 NS 48.13 51.87 48.1334.9 27.7 102.13 110.64 48.0049.3 28.9 81.25 18.75 81.2545.89 NS 67.80 40.68 55.0048.64 NS 49.39 50.61 45.83NS ( median 49) NS ( median 29.5 60.00 40.00 53.00NS NS 56.79 43.21 50.0036.33 23.94 71.33 28.67 66.6743.24 NS 80.52 19.48 68.4865.1 NS 95.49 4.51 88.2036.2 24.4 0.00 100.00 0.0057.1 NS 44.68 55.32 44.68NS NS 53.01 46.99 45.7947.47 NS NS (is the % givNS (is the % given NS (is the % give48.1 25.4 47.06 52.94 41.4641.7 NS 45.00 55.00 45.0051.9 30.1 52.00 48.00 72.0043.6 NS 49.51 50.49 49.8443.4 28.73 44.30 55.70 50.0041.88361111 Mean gender distri55.43 42.67 49.99

41.69 NS 60.00 40.00 25.0041.69 NS 100.00 100.00 18.1851.9 27.73 56.92 43.08 48.0852.7 NS 53.85 48.66 52.5347.4 NS 52.95 47.05 52.9548.4 26.46 49.00 51.00 44.0047.6 25.8 59.50 40.50 53.45NS NS NS NS NS55.63 24 33.77 25.97 67.9046.89 NS 57.87 42.13 60.6054.3 NS 52.12 47.88 50.2241 25 65.63 34.38 67.7451.2 28.5 34.58 65.42 57.07NS NS 56.00 44.00 56.0046,1 - 49,7 NS 46.67 50.61 38.85NS NS 59.42 46.95 NS63.8 27.7 47.34 52.66 44.9152.7 NS 100.00 0.00 100.00NS NS 49.09 50.91 49.1041.8 28.53 60.00 40.00 60.0047,1 - 54,9 NS 48.13 51.87 48.1334.9 27.7 102.13 110.64 48.0031.7 NS 72.22 27.78 60.0045.89 NS 67.80 40.68 55.0048.64 NS 49.39 50.61 45.83NS NS 56.79 43.21 50.00

36.33 23.94 71.33 28.67 66.67NS NS 41.67 58.33 NS43.24 NS 80.52 19.48 68.4865.1 NS 95.49 4.51 88.2057.1 NS 44.68 55.32 44.68NS NS 53.01 46.99 45.7947.47 NS NS (is the % givNS (is the % given NS (is the % give48.1 25.4 47.06 52.94 41.4641.7 NS 45.00 55.00 45.0048.1 NS 46.99 53.01 46.6451.9 30.1 52.00 48.00 72.0043.6 NS 49.51 50.49 49.8443.4 28.73 44.30 55.70 50.00

44.29580645 Mean gender distri57.00 45.29 51.99

52.7 NS NS NS NS51.9 27.73 56.92 43.08 48.0847.4 NS 52.95 47.05 52.9547.6 25.8 59.50 40.50 53.4555.63 24 33.77 25.97 67.90NS NS 57.87 42.13 60.6051 NS 50.14 49.86 47.9951.2 28.5 34.58 65.42 57.0746,1 - 49,7 NS NS NS NS45.7 29.1 49.37 50.63 47.1825.44 22.3 55.36 44.64 55.93NS 26.6 NS NS NS41.8 28.53 60.00 40.00 60.00NS NS NS NS NS60.1 29.1 NS NS NS60.1 26.6 NS NS NS43.24 NS 80.52 19.48 68.4857.1 NS 44.68 55.32 44.6848.1 25.4 47.06 52.94 58.5441.7 NS 45.00 55.00 45.0051.9 30.1 52.00 48.00 72.0046 25.7 43.16 56.84 NS36.69 23.29 57.52 42.48 57.2943.6 NS 49.51 50.49 49.8448.17368421 Mean gender distri51.66 46.10 55.70

52.7 NS NS NS NS47.4 NS 52.95 47.05 52.9547.6 25.8 59.50 40.50 53.4563.8 27.7 47.34 52.66 44.9145.89 NS 67.80 40.68 55.0048.64 NS 49.39 50.61 45.8336.33 23.94 71.33 28.67 66.6743.24 NS 80.52 19.48 68.4848.1 25.4 47.06 52.94 41.4643.4 28.73 44.30 55.70 50.0047.71 Mean gender distri57.80 43.14 53.19

52.7 NS NS NS 52.5339.8 26.5 63.04 36.96 63.0447.6 25.8 59.50 40.50 53.4555.63 24 33.77 25.97 67.90NS NS 57.87 42.13 60.6063.8 27.7 47.34 52.66 44.9141.8 28.53 60.00 40.00 60.0045.89 NS 67.80 40.68 55.0048.64 NS 49.39 50.61 45.8336.33 23.94 71.33 28.67 66.6743.24 NS 80.52 19.48 68.48NS NS 53.01 46.99 45.7943,54 for men & 48,4NS 54.00 46.00 51.0048.1 25.4 47.06 52.94 41.4643.4 28.73 44.30 55.70 50.0047.24416667 Mean gender distri56.35 41.38 55.29

% Women controls

39.4059.69

51.4847.4747.0532.1051.5842.9344.0053.14NS50.9350.9040.0051.8750.0054.1731.5255.3254.21NS (is the % given for cases anly or for (cases+cotrols)?)51.7527.0050.1646.88

51.9251.4847.9542.9360.02NS50.9350.9051.8754.17

55.32NS (is the % given for cases anly or for (cases+cotrols)?)27.0049.50

47.9550.9027.0032.6039.61

50.9051.4751.18

51.4859.6455.56

51.9211.4847.4747.0556.0036.9650.0046.550.0032.1039.4051.5842.9344.00NS58.35NS49.0059.2655.090.0050.90NS40.0024.0051.8751.00

70.0018.75100.00NS45.0054.1747.0050.0033.3349.2331.52NS11.80100.00NS55.3251.4759.4854.21NS (is the % given for cases anly or for (cases+controls)?)58.5453.3627.0050.1650.0055.0045.92

0.0075.0075.0051.92NS47.4747.0556.0036.9646.5532.1039.4052.0132.2642.9344.0058.35NS55.0949.0050.930.00

50.9040.0051.8751.0018.7545.0054.1747.0050.0033.3331.5211.80100.0055.3254.21NS (is the % given for cases anly or for (cases+cotrols)?)58.5455.0027.0050.1650.0044.89

75.0054.5551.9247.4747.0556.0046.55NS70.3739.4049.7832.2642.9344.0058.35NS55.090.0050.9040.0051.8751.0040.0045.0054.1750.00

33.33NS31.5211.8055.3254.21NS (is the % given for cases anly or for (cases+cotrols)?)58.5455.0053.3627.0050.1650.00

45.33

NS51.9247.0546.5570.3739.4052.0142.93NS57.2544.07NS40.00NSNSNS31.5255.3241.4655.0027.00NS42.7150.1646.75

NS47.0546.5555.0945.0054.1733.3331.5258.5450.0046.81

47.4736.9646.5570.3739.4055.0940.0045.0054.1733.3331.5254.2149.0058.5450.0047.44

Documents

Author Year Journal Total · 2013. 11. 12. · CV mortality Diabetes Mellitus (DM) Ahdout J 2012 Clin Exp Dermatol Alexander E 2001 IJDVL Al-Mutairi N 2010 J Dermatol Armesto S 2011