Details of Application for Doctorate by Students Expected to Complete the Doctoral Course of the Graduate School of Medical

Sciences in 2020 【A. Submitting a paper written by them as the first authors and published in a

Western scientific journal】

１．Requirements for Application for Doctorate （1） Students who are in the fourth year of the doctoral course and will be attending the school for more than

four years by the end of September or March.

（2） Students who are expected to earn the necessary credits for completion by the day of each review.

（3） The Interim review have been completed and The Research Proposal have been submitted.

（4） In order to apply for a doctorate, students are required to submit a Thesis.

２．Preliminary review Students who seek to apply for thesis defense must pass preliminary review by the Committee Professors

before applying for thesis review.

Please submit the following application documents to the Student Affairs Office of GSMS by the deadline. In addition, please inform us of the title of the paper by e-mail. ※Before submitting the application documents, please confirm with your supervisor whether you can publish

thesis or not.

※Please refer to Attachment 1 ”Deadline of Application for Doctoral degree in AY2020”.

◎Documents to Submit in Preliminary review

The documents can be downloaded from the website of GSMS.

http://www.medphas.kumamoto-u.ac.jp/medgrad/gakunai/sinsei/

「For Current Students」→「Degree application, Interim review」

（1） Check sheet （For Preliminary review） ・・・・・・・・・・・・・・・ 1 copy

（2） Application Form for Doctorate ・・・・・・・・・・・・・・・・・・・・・ 1 copy

（3） Letter of Consent for Submission of Thesis ・・・・・・・・・・・・ 1 copy

（4） Thesis（Including cover） ※1 ・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（5） Resume ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（6） Index of Thesis ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（7） Cover of Abstract ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（8） Abstract of Thesis (English version) ・・・・・・・・・・・・・・・・・ 1 copy

（9） Abstract of Thesis (Japanese version) ※2 ・・・・・・・・・・・・ 1 copy

（10） A pledge regarding research ethics ・・・・・・・・・・・・・・・・・・・ 1 copy

甲（A）

Please send the author name and the title of the Thesis with the sending title “Application for Doctorate:

XXXX (name of applicant)” via e-mail to the following address without attaching anything

Address： iyg-igaku-3@jimu.kumamoto-u.ac.jp

-1-

※1 If the thesis has not been published in a printed form, the manuscript of the thesis and a copy of a

letter or email stating that its publication has officially been decided shall be enclosed.

※2 Foreign students are not required to submit an abstract of the thesis (Japanese version).

Even if the publication of related papers has not been decided yet at the time of the preliminary review, we

will accept an application for the review if their publication is expected to be decided by the time of their

formal submission.

３．Formal submission Please revise the places which pointed out by committee, and prepare for the formal submission by the deadline.

※Please refer to Attachment 1 ”Deadline of Application for Doctoral degree in AY2020”.

◎Formal submission documents

（1） Check sheet（Formal submission） ・・・・・・・・・・・・・・・・・・・・・ 1 copy

（2） Application Form for Doctorate ・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（3） Letter of Consent for Submission of Thesis ・・・・・・・・・・・・・ 1 copy

（4） Thesis（Including cover） ※1 ・・・・・・・・・・・・・・・・・・・・・・・ 1 copy

（5） Resume ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 3 copy ［with signature and seal］

（6） Index of Thesis ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 3 copy ［with signature and seal］

（7） Cover of Abstract ・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・・ 3 copy

（8） Abstract of Thesis (English version) ・・・・・・・・・・・・・・・・・・ 3 copy ［About 300 words,

1 sheet］

（9） Abstract of Thesis (Japanese version) ※2 ・・・・・・・・・・・・・ 3 copy ［About 1200 characters,

1 sheet］

（10） A pledge regarding research ethics ・・・・・・・・・・・・・・・・・・・ 1 copy

（11） Statement of Depositing Doctoral Thesis ・・・・・・・・・・・・・・ 1 copy

（12） Statement of Depositing Abstract of Doctoral Thesis ※3 ・・ 1 copy

※1 If the thesis has not been published in a printed form, the manuscript of the thesis and a copy of a letter

or email stating that its publication has officially been decided shall be enclosed.

※2 Foreign students are not required to submit an abstract of the thesis (Japanese version).

※3 When applicants publish only a summary of the thesis for “unavoidable reasons”, they shall submit a

summary of the doctoral thesis in addition to this Application Form.

If the title is changed after publication, send the corrected title and promptly submit 3 copies of the corrected

application documents (with signature and seal) to Student Affairs Office.

４．Location to Submit Documents Student Affairs Office, Graduate School of Medical Science (Medical Education & Library Building 3F)

５．Schedule of Review of Thesis ※Please refer to Attachment 2 “Degree Application Schedule”

（1）Preliminary review

-2-

1st to 10th of every month from April 2020 to November 2020, "Documentary examination " by committee

professors.

（2）First Review

Documentary examination conducted at the educational committee on the third Wednesday and the Faculty

meeting on the fourth Wednesday, from April 2020 to November 2020 (this may be changed depending on

circumstances).

（3）Public Presentation

The date and place, and examiners will be announced after the first review.

（4）Second Review

Conducted at a faculty meeting on the fourth Wednesday of the month from May 2020 to February 2021 (this

may be changed depending on circumstances). The result of the review will be announced after the second

review.

◎Note （1）The Public Presentation will have 20 minutes of presentation and 10 minutes of discussion.

（2）Submit the Thesis and abstract to all the examiners one week prior to the public presentation (review).

６．Documents to be submitted after Second Review Students who pass Second Review are required to submit the following documents to the Student Affairs office

of GSMS. The method of submission will be notified when the test results are notified.

◎Documents to Submit

（1）Soft copy of doctoral thesis (full text) ・・・ For all Applicants

（2）Summary of the doctoral thesis (PDF) ・・ For Applicants who wish to publish thesis abstract

-3-

F o r m a t o f D o c u m e n t s t o b e S u b m i t t e d

１．Application Form for Doctorate

（1） Please sign and seal. (International Students may use their signatures instead of a seal.)

（2） Please write one of the following: “Medical Sciences”, “Life Sciences” and “Health Life Science” in the

parentheses.

２．Letter of Consent for Submission of Thesis

（1） The Academic advisor’s signature and seal are required.

If you have two professors, please get both of their signature.

（2） Please write candidate’s names of examiners.

A Chief examiner must be selected from professors in the GSMS.

Choose a professor for at least two of the four examiners.

An academic advisor, an introductory advisor, coauthors of Thesis, and advisors who belong to the same

department of applicant are not permitted to be examiners.

（3） Please write Co-authors of Thesis who belong to Kumamoto University as academic advisors.

Please be aware that the academic advisors whose name are not stated in the column might be selected as

your examiner.

３．Thesis

（1） To apply for a doctorate, applicants shall submit a thesis written by themselves as the lead authors.

（2） The thesis must be an article published in one of the “Western-language journals for application for a

doctorate”.

（3） Up to five published papers written by applicants themselves can be included in reference papers.

（4） If a paper was jointly written with other researchers based on equal contribution, both the applicant and

other researchers will regarded as the lead authors, if this is specified in the paper. (Consent to the

submission of the paper as a thesis must be obtained from other researchers in advance.)

４．Resume （1） Prepare the margins: top 25 mm, bottom 15 mm, left 25 mm, right 15 mm.

（2） The font size of the title should be 12 point, while the size of the text should be 10 point.

（3） Signature and seal using black ink or a black ballpoint pen and submit 3 original copies.

（4） The resume should be no more than one page each.

（5） Kana over name to indicate pronunciation.

（6） International Students shall enter their nationality.

-4-

（7） Please state your educational background starting from graduation of bachelor’s degree of the University.

※Please provide the exact date of graduation, which stated on the graduation certificate etc.

（8） Your research history should include only student registration period at graduate school of Medical

Sciences.

５．Index of Thesis

（1） Prepare the margins: top 25 mm, bottom 15 mm, left 25 mm, right 15 mm.

（2） The font size of the title should be 12 point, while the size of the text should be 10 point.

（3） Signature and seal using black ink or a black ballpoint pen and submit 3 original copies.

（4） The index of Thesis should be no more than one page each.

（5） Kana over name to indicate pronunciation.

（6） A Japanese translation of the title enclosed in brackets shall be added to the English title.

（7） Titles written on the “thesis”, “index of theses”, and “cover of the abstract” must be the exact same, every

single word and phrases.

（8） When there are published articles other than Thesis, indicate up to five.

The titles of reference articles should correspond with those in the printed matter (use of upper and lower

case letters, italics, and others) as shown in a sample.

６．Abstract of Thesis

（1） A cover should be attached to the Abstract of Thesis.

Titles written on the “thesis”, “index of theses”, and “cover of the abstract” must be the exact same.

（2） Abstract should be summarized simply and clearly in about 300 words in English.

（3） As the sample shows, it is recommended in principle that the abstract be divided into objective, method,

results, discussion, and conclusion.

（4） Minimize the use of abbreviations. When using an abbreviation for the first time, write the words in full

followed by the abbreviation in parentheses. Example: Duchenne muscular dystrophy (DMD). However, this

does not apply to abbreviations widely recognized in medical science and biology (for instance: DNA, ATP).

（5） After graduation, in principle abstract of thesis will be published on Kumamoto University website within

3 months.

Especially, please note about the description of research results involving intellectual property.

７．Statement of Depositing Doctoral Thesis In accordance with a recent partial revision of the rules for the granting of academic degrees,

persons who have been granted a doctoral degree on April 1, 2013, or later (the recipients of degrees) shall, in principle, register the full text of the thesis for which they have received the

-5-

degree in the Kumamoto University Academic Repository and publish it on the Internet. （1） The application must be signed (sealed) by the supervisor.

（2） Prior to the publication of the full text of the doctoral thesis, applicants shall confirm that the publication

will not affect the publisher, co-authors, co-researchers, collaborative companies, or other related people.

（3） If the applicant publishes only the abstract of the dissertation due to "unavoidable reasons", submit " Statement of Depositing Abstract of Doctoral Thesis " together.

（4） Please check the Kumamoto University Academic Repository homepage for notes on Internet publication.

（https://www.lib.kumamoto-u.ac.jp/collections/repository/about）

-6-

※Submit the thesis using this check sheet as the cover.

（甲）Check sheet（Preliminary review） A. Submitting a paper written by them as the first authors and published

in a Western scientific journal

Name of the applicant

Student number

Affiliation

Contact 1 (mobile phone)

Contact 2 (Affiliation)

Email address (valid address)

Confirm the following documents before you submit them, and check the box ( □ ) for each document.

※Please be sure to submit documents in hard copy.

Documents Number Confirmation items

□ Interim review － □The Interim review have been completed and The Research Proposal have been submitted.

□ Application form 1copy □Signed and stamped by yourself. □Write the degree type.

□ Letter of consent for Submission of

Thesis 1copy

□Signed and stamped by the Academic advisor. □The Chief examiner is one of the professors from the

GSMS. □Choose a professor for at least two of the four

examiners. □Examiner candidates do not include co-authors.

□ Cover of Thesis 1copy □The title matches index of thesis and abstract .

□ Thesis 1copy

□Ensure that the thesis is not classified as a short communication.

□The thesis must be an article published in one of the “Western-language journals for application for a doctorate”.

□In the case of related papers in press or posting: A copy of an email stating that the thesis has been posted its publication has officially been decided must be enclosed.

□ Resume 1copy

□Academic background is listed from graduation of Bachelor’s degree. □Research history should include only research history

during graduate school. □The date of submission is described. □Signed and stamped by yourself.

□ Index of thesis 1copy □The title matches thesis and abstract . □The date of submission is described. □Signed and stamped by yourself.

□ Cover of Abstract 1copy □The title matches thesis and index of thesis .

□ Abstract of Thesis 1copy □About 300 words, 1 sheet.

□ A pledge regarding research ethics 1copy □Check the check box (applicant, supervisor) □Signed (applicant, supervisor)

□ Send the author name and the title of the Thesis with the sending title “Application for doctoral degree: XXXX (name of applicant)” via e-mail to the following address without attaching anything. Address：iyg-igaku-3@jimu.kumamoto-u.ac.jp

-7-

※Submit the thesis using this check sheet as the cover.

（甲）Check sheet（Formal submission） A. Submitting a paper written by them as the first authors and published

in a Western scientific journal

Name of the applicant

Student number

Affiliation

Contact 1 (mobile phone)

Contact 2 (Affiliation)

Email address (valid address)

Confirm the following documents before you submit them, and check the box ( □ ) for each document.

※Please be sure to submit documents in hard copy.

Documents Number Confirmation items

□ Check if all mistakes and errors pointed out by the preliminary review have been corrected.

□ Application form 1copy □The date of submission is described.

□ Letter of consent for Submission of

Thesis 1copy □The date of submission is described.

□ Cover of Thesis 1copy

□ Thesis 1copy

□In the case of related papers in press or posting: A copy of an email stating that the thesis has been posted its publication has officially been decided must be enclosed.

□ Resume 3copy □3 original copies with signature and seal.

□ Index of thesis 3copy □3 original copies with signature and seal.

□ Cover of Abstract 3copy

□ Abstract of Thesis 3copy

□ A pledge regarding research ethics 1copy

□ Statement of Depositing Doctoral Thesis

1 copy □Signed and stamped by yourself. □Stamped by the Academic advisor.

□

Statement of Depositing Abstract of

Doctoral Thesis

※If applicants publish only a summary of

the thesis for “unavoidable reasons”.

1 copy

□Signed and stamped by yourself. □Stamped by the Academic advisor. □Submit a publication of summary.

-8-

Year/Month/Day

To the Dean of the Graduate School of Medical Sciences Applicant FAMILY First Middle Seal （Sign）

Application for Doctorate I hereby apply for the Doctorate of ( Medical Sciences ) with the Thesis, the resume and the index of the Thesis attached.

-9-

Year/Month/Day

To the Dean of the Graduate School of Medical Sciences

Letter of Consent for Submission of Thesis

With regard to the submission of the Thesis written by (Applicant name) FAMILY First Middle , I confirm that the documents to be submitted, such as the Thesis, the index of the Thesis, and the abstract of the Thesis, are appropriately made in accordance with the format stated in “How to Make Application Documents for Thesis,” and agree to submit the Thesis

Academic (introductory) advisor Name 山田 一郎 Seal

（Sign）

Please write candidate’s names for examiners

Head of examiner Professor ◯◯ ◯◯

E x a m i n e r Professor △△ △△

E x a m i n e r Professor □□ □□

E x a m i n e r Professor ◇◇ ◇◇ ※ An academic advisor, an introductory advisor, coauthors of Thesis, and advisors who belong to the same

department of applicant are not permitted to be examiners.

Co-authors of Thesis who belong to Kumamoto University as academic advisors are as below.

◯◯ ◯◯、 ◯◯ ◯◯、 ◯◯ ◯◯、 ◯◯ ◯◯

◯◯ ◯◯、 ◯◯ ◯◯、 ◯◯ ◯◯、 ◯◯ ◯◯

（※Please be aware that the academic advisors whose name are not stated above might be selected as your examiner.）

-10-

学位論文

Diversity in antigen recognition by and immune response of the human CD4+ T cell clone

（ヒト CD4 陽性 T 細胞クローンの認識抗原ペプチドと免疫応答の多様性）

Kana pronunciation Name

（FAMILY First Middle）

Department of XX, Medical Sciences Major, Doctoral Course of the Graduate School of Medical Sciences,

Kumamoto University

Academic advisor

(Associate) Professor YAMADA Ichiro Department of XX, Medical Sciences Major,

Doctoral Course of the Graduate School of Medical Sciences, Kumamoto University

September 2021

Use this format for the application for the Thesis.

※If the Thesis is written in English, its title should be English with a Japanese

translation provided in parentheses.

※Names should be centered

＜In the case you belong to the Course＞ Course of XX, Medical Sciences Major,

Doctoral Course of the Graduate School of Medical Sciences, Kumamoto University

※Academic advisors should indicate their present affiliation

-11-

[If all of your academic advisors are professors who have retired or left Kumamoto University]

Academic advisor

Former Professor XXX XXX

Department of XX, Medical Sciences Major Doctoral Course of the Graduate School of Medical Sciences,

Kumamoto University

Introductory Professor Professor XXX XXX

Department of XX, Medical Sciences Major,

Doctoral Course of the Graduate School of Medical Sciences, Kumamoto University

○If your academic advisors include instructors who do not belong to your major department, write all of

their names. When doing so, write the name of the person in charge of research guidance in your

official affiliation at the top of the list.

○Even if your academic advisors are instructors who have retired or left Kumamoto University, from a

practical standpoint, write their names as if they still belonged to Kumamoto University.

○If all your academic advisors are instructors who have retired or left Kumamoto University, submit

your application through an introductory professor (who must be a member of the faculty council of

the Graduate School of Medical Sciences) and also record his/her name on the abstract.

-12-

履 歴 書 Resume

Account No. 甲 第 号

Name Kana pronunciation

FAMILY First Middle

Female

Date of birth September 25, 1981

Nationality Myanmar

Present address Honjo 1-1-1, Chuo-ku, Kumamoto-shi Kumamoto, JAPAN

Educational Background

2010/6/25 Graduate: Bachelor of Medicine and Bachelor of Surgery, University of Medicine, Yangon, Myanmar 2010/7/1 Enrolled: Master of Medical Science, Department of Microbiology, University of Medicine, Yangon, Myanmar 2012/6/30 Post Graduate, Master of Medical Science, Department of Microbiology, University of Medicine, Yangon, Myanmar 2017/4/1 Enrolled: Graduate School of Medical Sciences, Kumamoto University (Doctoral couese)

2021/3/25 Expect to complete the above course

Research History

From 2017/4/1 Graduate School of Medical Sciences, Kumamoto University (Doctoral couese) To 2021/3/25 received guidance from professor Ichiro yamada

Work Experience From 2012/7/1 Assistant Lecture, Department of Microbiology, University of Medicine, To 2014/9/30 Yangon, Myanmar

From 2014/10/1 Lecture, Department of Microbiology, University of Medicine, Mandalay, Myanmar

To the present date

The above statement is true and correct

2020/◯◯/◯◯

Name Kyu Kyu Maung Seal

（Sign）

※Please fill in from university graduation of Bachelor’s degree.

＜For withdrawal in 2020＞

2020/3/24 Complete the above course without degree

※If you have two professors, write both of their names.

A4 1sheet

*When the name is written in kanji,

spelling in Latin letters is unnecessary.

-13-

論文目録 Index of Thesis Account No.

甲第 号

Name Kana pronunciation

FAMILY First Middle

Main T hesis

冊 数

１編 １冊

Author

Hanako Kumamoto, Taro Fukuoka, Jiro Miyazaki

T i t le o f Thes is

Diversity in antigen recognition by and immune response of the human CD4+ T cell clone

（ヒトCD4 陽性T細胞クローンの認識抗原ペプチドと免疫応答の多様性）

Journal

J.Immunol. 157: 3783-3790, 2018

Reference articles

冊 数

２編 ２冊 1．Hanako Kumamoto, Taro Fukuoka and Jiro Miyazaki. Response of a human T cell clone to a large panel of altered peptide ligands carrying single residue substitutions in an antigenic peptide; characterization and frequencies of TCR agonism and TCR antagonism with or without partial activation. J.Immunol. 157: 3783-3790, 1996. 2. Kumamoto, H., Kagoshima, S., and Nagasaki, S., Miyazaki, J., Modulation of calcium response by altered peptide ligands in a human T cell clone. Eur.J.Immunol. 28: 3929-3939, 1998.

The above statement is true and correct.

2020/◯◯/◯◯

Name Seal

（Signature）

※Fill in all members in the order they were published.（except “and”） ※In case the paper is a joint work between the applicant and another researcher on equal contribution basis, please indicate that.

※If you enter the thesis title in a foreign language, its Japanese translation has to be added in parentheses( ). ※The titles recorded in the Thesis, the index of the Thesis, and

the cover of the abstract should correspond with one another.

※The titles of reference articles should correspond with those in the printed matter (use of upper and lower case letters, italics, and others) as shown in a sample.

※When there are published articles other than Thesis, indicate up to five.

A4 1Sheet

-14-

学位論文抄録 Abstract of Thesis

Diversity in antigen recognition by and immune response of the human CD4+ T cell clone

(ヒト CD4 陽性 T 細胞クローンの認識抗原ペプチドと免疫応答の多様性)

Kana pronunciation

Name （FAMILY First Middle）

Department of XX, Medical Sciences Major, Doctoral Course of the Graduate School of Medical Sciences,

Kumamoto University

Academic advisor

(Associate) Professor XXX XXX

Department of XX, Medical Sciences Major, Doctoral Course of the Graduate School of Medical Sciences,

Kumamoto University

※If the Thesis is written in English, its title should be English with a

Japanese translation provided in parentheses

※If all of your academic advisors are professors who have retired or left Kumamoto

University, Please write together former professor and introductory professor.

＜In the case you belong to the Course＞ Course of XX, Medical Sciences Major,

Doctoral Course of the Graduate School of Medical Sciences, Kumamoto University

※Academic advisors should indicate their present affiliation

-15-

Abstract of the Thesis Background and Purpose: In order to establish cancer immunotherapy, it is important to identify the tumor-associated antigens (TAAs) that are strongly expressed in the tumor cells but not in the normal cells. In this study, to establish an effective anticancer immunotherapy, we tried to identify the ideal TAA of pancreatic cancer. Methods: Based on a previous genome-wide cDNA microarray analysis of pancreatic cancer, we focused on Cadherin 3 (CDH3)/P-cadherin as a novel candidate TAA for anticancer immunotherapy. To identify the HLA-A2 (A*0201)-restricted CTL epitopes of CDH3, we used HLA-A2.1 (HHD) transgenic mice (Tgm). Furthermore, we examined the cytotoxicity against the tumor cells in vitro and in vivo of CTLs specific to CDH3 induced from HLA-A2-positive healthy donors and cancer patients. Results: CDH3 was overexpressed in the majority of pancreatic cancer and various other malignancies, including gastric and colorectal cancers, but not in their non-cancerous counterparts, or in many normal adult tissues. In the experiment using HLA-A2.1 Tgm, we found that the CDH3-4655-663 (FILPVLGAV) and CDH3-7757-765 (FIIENLKAA) peptides could induce HLA-A2-restricted CTLs in Tgm. In addition, peptides-reactive CTLs were successfully induced from PBMCs by in vitro stimulation with these two peptides in HLA-A2 positive healthy donors and cancer patients, and these CTLs exhibited cytotoxicity specific to cancer cells expressing both CDH3 and HLA-A2. Furthermore, the adoptive transfer of the CDH3-specific CTLs could inhibit the tumor growth of human cancer cells engrafted into NOD/SCID mice. Conclusions: The CDH3 is a novel TAA useful for broad-spectrum cancer immunotherapy for pancreatic, gastric and colorectal cancers.

A sample of an abstract written in English A4 版

-16-

(English)

A Pledge Regarding Research Ethics

To the Dean of the Graduate School of Medical Sciences:

I hereby pledge that there is no violation of research ethics with respect to the dissertation I have submitted, as

described in the following table; “the papers” in this document refer to both “the dissertation” and “its related papers”:

Confirmation items

Field to be

checked by the

applicant

Field to be

checked by the

supervisor

1

There are laboratory notebooks to confirm the experiments and data

analyses described in the papers. Experimental procedures and methods

are appropriately described in the papers.

☑ ☑

2 All data included in the dissertation have been stored as raw data. ☑ ☑

3 Images, tables, figures, and sentences created or written by other people

have not been quoted in the dissertation without permission. ☑ ☑

4 Images, tables, figures, and sentences have not been reused improperly. ☑ ☑

5 Images have not been processed improperly: deletion of part of images

or addition to images. ☑ ☑

6

As for each single panel consisting of multiple electrophoresis

photographs and microscopic images, the borders have been clearly

presented.

☑ ☑

7

Images from experiments conducted under different conditions have not

been arranged to guide the readers of the dissertation to think that the

experiments were implemented under the same conditions.

☑ ☑

*8 The dissertation complies with the ethical guidelines for clinical

research. □ □

*8 applies to the dissertation of research in which human specimens were used.

(Signature) Kyu Kyu Maung Date: 2020/◯◯/◯◯

Degree applicant

(Signature) Ichiro Yamada Date: 2020/◯◯/◯◯

Supervisor

-17-

博士論文のインターネット公表について

Publication of doctoral thesis on the Internet

このたび、学位規則が一部改正され、平成２５年４月１日以降に博士の学位を授与された者（以下「学位被授与

者」）は、博士の学位を授与された日から 1 年以内に、当該博士の学位の授与に係る論文全文を熊本大学学術リ

ポジトリ（以下「リポジトリ」）に登録し、インターネット公表することが原則となりました。 In accordance with a recent partial revision of the rules for the granting of academic degrees, persons who have been

granted a doctoral degree on April 1, 2013, or later (the recipients of degrees) shall, in principle, register the full text of the thesis for which they have received the degree in the Kumamoto University Academic Repository and publish it on the Internet.

また、博士論文をインターネット公表するにあたり、博士論文に関する権利関係や各種申請等※1 について、学

位被授与者自身が必ず事前に確認・申請をしておく必要があります。 Prior to the publication of doctoral theses, the recipients of degrees must confirm relevant rights and submit required

applications in relation to the doctoral theses*1 in advance. なお、学位被授与者が権利関係等の確認後、博士論文の全文が公表できない「やむを得ない事由」（全文をイ

ンターネット公表することによる不利益）があると判断した場合※2 は、所属する研究科（又は教育部）長の承認を得

て、全文に代えてその内容の要約をインターネット公表することになります。ただし、「やむを得ない事由」が解消し

た場合は、博士論文の全文をインターネット公表しなければなりません。 If the recipients of degrees have decided that they cannot publish the full text of the doctoral thesis for “unavoidable

reasons” (the recipients will be disadvantaged by publishing the full text on the Internet) after confirming relevant rights,*2 they may publish a summary, rather than the full text, of the doctoral thesis with the approval of the graduate school (Graduate School of Medical Sciences). However, the recipients must publish the full text of the doctoral thesis when “unavoidable reasons” no longer exist.

ついては、学位被授与者は下記の博士論文のインターネット公表手続きを必ず行ってください。 The recipients of degrees must go through the procedures for the publication of doctoral theses on the Internet. 学位論文をインターネット公表する前に、関連論文掲載雑誌の著作権ポリシーをよく理解し、同ポリシーに従っ

て下さい。主な科学雑誌の著作権ポリシーは、SHERPA/RoMEO(http://www.sherpa.ac.uk/romeo/index.php)で

検索することができます。ただし、同ウェブサイトに掲載されているものが最新の著作権ポリシーとは限りませんの

で、各雑誌に掲載されている著作権ポリシーを読むことをお勧めします。 Prior to the publication of theses, the recipients shall read, understand, and comply with the copyright policies of

journals in which related papers have been published. The recipients can conduct searches for the copyright policies of principal journals on the website: “SHERPA/RoMEO (http://www.sherpa.ac.uk/romeo/index.php)”. However, the copyright policies published on the website may not be the latest ones. The recipients are advised to read the copyright policies published in each relevant journal.

【博士論文のインターネット公表手続き】 [Procedures for the publication of doctoral theses on the Internet] １．「博士論文インターネット公表申請書」を作成する。

Create “an application for the publication of doctoral theses on the Internet”. 申請書については、指導教員（論文博士の場合は、関係教員）の押印が必要です。必ず、指導教員に確認

した上で作成してください。（学位の種類、学位記番号、学位授与年月日は記入不要です。） The application must be signed (sealed) by the supervisor (a relevant academic staff in the case of the receipt of a doctorate by submitting a thesis). The application must be confirmed by the supervisor (the type of the thesis, its number, and the date of its receipt do not have to be stated).

２．以下に掲載する①、②を所属する研究科（教育部）の教務担当に提出する。 Submit the following ((1) and (2)) to the Student Affairs Section of the graduate school (Graduate School of Medical Sciences): ①博士論文全文（PDF 形式に変換し、CD-R や USB メモリ等、電子形態で提出）

Full text of the doctoral thesis (converted into PDF format and submitted in an electronic format, including CD-R and USB memory)

②博士論文インターネット公表申請書（要押印） Application for the publication of doctoral theses on the Internet (signed).

ただし、「やむを得ない事由」により論文の要約のみを公表する場合は、上記①、②に加え、下記③博士論

文の要約を併せて提出する。 When applicants publish only a summary of the thesis for “unavoidable reasons”, they shall submit a summary of the doctoral thesis as stated in (3), in addition to the documents explained in (1) and (2).

③博士論文要約（PDF 形式に変換し、CD-R や USB メモリ等、電子形態で提出） Summary of the doctoral thesis (converted into PDF format and submitted in an electronic format, including CD-R and USB memory)

-18-

なお、「やむを得ない事由」がなくなり、全文が公表できるようになった場合は、「博士論文インターネット公

表申請書」を再度、作成し提出する。 When “unavoidable reasons” no longer exist and the full text of the thesis can be published, applicants shall recreate and submit “an application for the publication of doctoral theses on the internet”.

※提出する PDF ファイルや媒体には、パスワードの設定を行わないでください。また、外部情報源（外部

フォント等）を参照しないようにしてください。 *Do not set passwords for PDF files and other media to be submitted. Do not refer to external information

sources (including external fonts).

【リポジトリへの登録及び公表について】[Repository registration and publication] 提出された博士論文インターネット公表申請書は、関連資料とともに附属図書館に送付されます。その申請書

にもとづき、附属図書館は博士論文全文または博士論文要約をリポジトリに登録し、インターネット公表を行いま

す。

リポジトリ登録およびインターネット公表に関する Q&A を、熊本大学学術リポジトリ FAQ※3 をホームページに掲

載していますので参照してください。 The submitted application for the publication of doctoral theses on the Internet along with related documents will be

sent to the university library. The library will register the full text or a summary of the doctoral thesis in the repository based on the application, and publish it on the Internet.

Please refer to the Q&A section related to repository registration and Internet publication on the website Kumamoto University Academic Repository FAQ.*3

【国立国会図書館における利用】[Utilization of the National Diet Library] 提出された博士論文全文は、インターネット公表の有無に関わらず国立国会図書館へ送付され、国立国会図

書館法及び著作権法が定める範囲において、閲覧、複写等に利用されます。

なお、博士論文要約を公表する者で全文閲覧に支障を来す場合（特許出願の手続中等）は、その旨を申し出て

ください。本学から国立国会図書館へ利用に制限が必要である旨を要望します。 The submitted full texts of doctoral theses will be sent to the National Diet Library, regardless of whether they are

published on the Internet or not, for viewing and copying under the National Diet Library Act and the Copyright Act. Applicants who wish the publication of a summary, rather than the full text, of the doctoral thesis (for patent pending or

other reasons) shall inform the university. The university will inform the National Diet Library of the necessity of its usage restrictions.

※１ 博士論文に関する権利関係や各種申請等について *1 Rights and applications related to doctoral theses

博士論文全文を公表するにあたって、関係者（出版社・共著者・共同研究者・共同研究企業等）へ公表の

支障の有無について事前確認を行うこと。

特に、共同研究契約等の契約がある場合は、当該契約内容を確認し、必要があれば事前に承諾を得るこ

と。

なお、特許出願等が必要な場合は、必ず学位申請前に手続き等を行うこと。 Prior to the publication of the full text of the doctoral thesis, applicants shall confirm that the publication will not

affect the publisher, co-authors, co-researchers, collaborative companies, or other related people. Written agreements, including those on collaborative research in particular, must be checked, and consent shall be

obtained in advance if necessary. If graduate students are required to submit patent and other applications, they must undergo the procedures prior

to applying for the degree.

※２ 権利関係等確認後、「やむを得ない事由」があり、全文に代えてその内容の要約を公表する場合には、原則、

学位申請時に「博士論文要約公表申請書」を提出し、研究科長（又は教育部長）の承認を得ておかなければ

なりません。 *2 If applicants publish a summary of the thesis, rather than its full text, for “unavoidable reasons” after confirming

relevant rights, they must submit an “application for the publication of summaries of doctoral theses” at the time of applying for the degree to obtain the approval of the head of the graduate school (Graduate School of Medical Sciences).

「やむを得ない事由」の判断基準 Criteria for “unavoidable reasons”

（１）本論文に立体形状等を含み、インターネット上で公表できないため It is difficult to understand 3D illustrations included in the thesis published on the Internet. （２） 雑誌への投稿及び図書刊行に支障をきたすため

Authors may have difficulty submitting their theses to journals or publishing them in book form.

-19-

（３） 雑誌へ投稿済みかつ雑誌出版社の方針で多重公表を禁止しているため The thesis has already been submitted to journals and their policies ban any other publications. （４） 共著者、共同研究者、共同研究企業の承諾が得られないため Co-authors, collaborators, and collaborative companies do not consent to its publication on the Internet. （５） 特許等の申請に支障をきたすため Authors have difficulty applying for patents. （６） 共同研究者等の他者における知的財産権を侵害する場合 The publication may infringe the intellectual property rights of others including collaborators. （７） 論文中に個人情報を含み、インターネット上で公表できないため The thesis cannot be published on the Internet because it includes personal information. （８） その他公表により不利益が生じるため The publication of the thesis on the Internet may create other disadvantages.

※３ 熊本大学学術リポジトリ FAQ（随時更新） *3 Kumamoto University Academic Repository FAQ (updated on an as-required basis)

http://www.lib.kumamoto-u.ac.jp/collections/repository/faq

その他、不明な点がある場合は、下記担当までお問い合わせください。 If you have any inquiries, please contact the following offices:

【博士論文のインターネット公表に関する問い合わせ先】 Contacts regarding the publication of doctoral theses on the Internet ○博士論文の公表手続き等に関すること

Procedures for the publication of doctoral theses 所属する研究科（教育部）の教務担当

Persons in charge of student affairs in the graduate school (Graduate School of Medical Sciences)

○博士論文の学術リポジトリ登録・公表内容及び著作権に関すること

Registration of doctoral theses in the academic repository, their publication, and copyrights 熊本大学教育研究推進部図書館課 電子情報担当

Persons in charge of electronic information, the Library Section, Advanced Research/Education Promotion Division, Kumamoto University TEL：096-342-2224 E-mail：denjo@lib.kumamoto-u.ac.jp

○特許及び知財の取扱いに関すること

Handling of patents and intellectual properties 熊本大学マーケティング推進部社会連携課

Social Collaboration Section, Marketing Promotion Office, Kumamoto University TEL：096-342-3145 E-mail：sangaku-renkei@jimu.kumamoto-u.ac.jp

-20-

博士論文を学術雑誌へ投稿中もしくは投稿予定の方へ （チェックシート含む）

博士論文を学術雑誌等へ投稿する場合、掲載要件として未発表の論文と条件を付される場合があ

ります。よって、学術雑誌へ投稿中もしくは投稿予定の方は、掲載要件に反することが無いように、

博士論文のリポジトリ登録手続きを行うようにしてください。また、雑誌掲載後に、原稿となった博士

論文をリポジトリに登録できるかどうか、確認を行うようにしてください。

投稿中・投稿予定雑誌の情報

雑誌名 論題 １．雑誌掲載前に、リポジトリへ登録しインターネット公表ができますか？ （出版社等へご確認ください） □可能 → リポジトリに登録できます □不可 → 本シート作成時点ではリポジトリへの登録はできません ２．雑誌掲載後、原稿（博士論文）をリポジトリへ登録し、インターネット公表ができますか？ （出版社等へご確認ください） □可能 → リポジトリに登録できます □掲載条件付きで可能

□条件を許容できる → リポジトリに登録できます □条件を許容できない → リポジトリへの登録はできません（要約公表）

□不可 → リポジトリへの登録はできません（要約公表） 作業欄

出版社の連絡先・担当者 許諾状況・掲載条件 □登録猶予期間の設定（ ヶ月） □出典の明記 （ 掲載誌情報 ・ DOI ・ Pubmed-ID ） □原稿種別の指定（ 出版社版 ・ 著者版 ）

□出版社版へのリンク □著作権者の明記 □許諾書等の提出 （→□提出完了）

□その他

本人確認用

（提出不要）

-21-

博士論文インターネット公表申請書

Statement of Depositing Doctoral Thesis

年/Y 月/M 日/D

熊本大学附属図書館長 殿 To Director of Kumamoto University Library

学生番号 student number

氏名（自署）name (signature) 印seal

指導教員名 supervisor 印seal

下記の博士論文について、附属図書館において熊本大学学術リポジトリに登録し、インターネット公表

することを申請します。I hereby agree to deposit the electronic copy of my doctoral thesis into Kumamoto University Academic Repository at the university library and publicize the data to be freely available via internet.

1. 博士論文題目 Thesis title

Diversity in antigen recognition by and immune response of the human CD4+ T cell clone （ヒト CD4 陽性 T 細胞クローンの認識抗原ペプチドと免疫応答の多様性）

2. 公表の種別 Publication

全文 All contents ／ 要約 Abstract (○で囲んでください。)

3. 博士論文が既に学術雑誌等で印刷公表されている場合の論文タイトル、著者名、雑誌名、

巻・号・ページ、年次など If your thesis is to be published, please state the title, author, publisher, Vol. no., page, date, etc.

Journal of AAAA 40(1) 2013.1 p40-93

4. その他連絡事項等 others

附属図書館はこの申請書に基づき、熊本大学学術リポジトリ登録及びインターネット公表にかかる作業を

行います。申請者は、下記の事項について、承諾したものとみなします。 The university library will prepare for Kumamoto University Academic Repository and publication on the internet according to this application so you agreed the following.

(1) データベース化について Compiling a database a) 博士論文のページイメージを PDF データとしてハードディスク等に蓄積すること。

Compile the doctoral thesis electronic copy in PDF file. b) 博士論文の目録情報・抄録情報をテキストデータとしハードディスク等に蓄積すること。 Compile the contents or abstract of the thesis in text data. c) 上記により作成されるPDFデータとテキストデータを関連づけて熊本大学学術リポジトリに登録

しデータベースとして作成すること。Deposit the both a) and b) into Kumamoto University Academic Repository and compile in database.

学位の種類 博士（ ）

学位記番号

学位授与年月日 年 月 日

000A0000

○○ ○○

○○ ○○

-22-

(2) 利用について Database use a) 学内外の利用者が、インターネットなどのネットワークを経由して、熊本大学学術リポジトリを

検索し本文ページの閲覧及び印刷をすること。 Internal and external users can search, browse and print the repository via internet then.

b) 博士論文のメタデータ（書誌情報）を、学外のシステムが収集して公開すること。 External system collects and publicizes the metadata of the thesis.

(3) その他 Others その他詳細については、熊本大学学術リポジトリ運用指針によること。 The others will be followed Kumamoto University Academic Repository Policy.

-23-

博士論文要約公表申請書 Statement of Depositing Abstract of Doctoral Thesis

年/Y 月/M 日/D

医学教育部長 殿 To Dean of Graduate School of Medical Sciences

学生番号 Student ID

氏名 Name（自署 signature） 印

指導教員名 Supervisor 印 提出しました博士論文について、下記のやむを得ない事由に該当するため、博士学位を授与された後の熊本

大学学術リポジトリでの公表を全文に代えて内容を要約したものとすることを申請します。I declare to deposit the abstract of my doctoral thesis into Kumamoto University Academic Repository after conferment of degree due to the compelling reasons below.

記

□本論文に立体形状等を含み、インターネット上で公表できないため Works of art □雑誌への投稿及び図書刊行に支障をきたすため Affect publication ☑雑誌へ投稿済みかつ雑誌出版社の方針で多重公表を禁止しているため

Duplicate publication has been prohibited when previous journal disclosed □共著者、共同研究者、共同研究企業の承諾が得られないため

Unauthorized by coauthor and collaborator □特許等の申請に支障をきたすため Patent infringement

□申請済 date of application（ 年 月 日） □申請予定 date of expecting to apply（ 年 月頃）

□共同研究者等の他者における知的財産権を侵害する場合 Intellectual property right of collaborated company

□論文中に個人情報を含み、インターネット上で公表できないため Including personal information ページ及び概要 Page and contents

□その他の事由 Others

○該当する事由を選択または記入してください。（必須・複数選択可）

Please choose the compelling reasons. (multiple selection is accepted)

000A0000

○○ ○○

○○ ○○

-24-

Abstract Sample Diversity in antigen recognition by and immune response of the human CD4+ T cell clone （ヒト CD4 陽性 T 細胞クローンの認識抗原ペプチドと免疫応答の多様性） The title of thesis must be specify both English and Japanese.

Background and Purpose: In order to establish cancer immunotherapy, it is important to identify the tumor-associated antigens (TAAs) that are strongly expressed in the tumor cells but not in the normal cells. In this study, to establish an effective anticancer immunotherapy, we tried to identify the ideal TAA of pancreatic cancer. Methods: Based on a previous genome-wide cDNA microarray analysis of pancreatic cancer, we focused on Cadherin 3 (CDH3)/P-cadherin as a novel candidate TAA for anticancer immunotherapy. To identify the HLA-A2 (A*0201)-restricted CTL epitopes of CDH3, we used HLA-A2.1 (HHD) transgenic mice (Tgm). Furthermore, we examined the cytotoxicity against the tumor cells in vitro and in vivo of CTLs specific to CDH3 induced from HLA-A2-positive healthy donors and cancer patients. Results: CDH3 was overexpressed in the majority of pancreatic cancer and various other malignancies, including gastric and colorectal cancers, but not in their non-cancerous counterparts, or in many normal adult tissues. In the experiment using HLA-A2.1 Tgm, we found that the CDH3-4655-663 (FILPVLGAV) and CDH3-7757-765 (FIIENLKAA) peptides could induce HLA-A2-restricted CTLs in Tgm. In addition, peptides-reactive CTLs were successfully induced from PBMCs by in vitro stimulation with these two peptides in HLA-A2 positive healthy donors and cancer patients, and these CTLs exhibited cytotoxicity specific to cancer cells expressing both CDH3 and HLA-A2. Furthermore, the adoptive transfer of the CDH3-specific CTLs could inhibit the tumor growth of human cancer cells engrafted into NOD/SCID mice. Conclusions: The CDH3 is a novel TAA useful for broad-spectrum cancer immunotherapy for pancreatic, gastric and colorectal cancers.

-25-

【令和2年度】 医学教育部博士課程・修士課程 学位論文審査申請期限 Deadline of Application for Doctoral degree or Master’s degree in AY 2020

申請者は各自提出締め切りを確認し、期限に間に合うよう、申請をしてください。 申請区分ごとの申請要項等は別に定められています。申請資格や提出物などは、必ずそちらを確認してください。

【医学教育部ウェブサイト】 学生教職員へのお知らせ > 学位申請・中間審査について http://www.medphas.kumamoto-u.ac.jp/medgrad/gakunai/sinsei/

The deadline or period of degree application in this year are as follows. Please refer to these deadlines, make sure to submit the required documents before the due date. In addition, the application guidelines for each category are specified separately. Please make sure to confirm the Assessment Criteria, Detail of Application, Application Form, etc.

【Website of GSMS】 For Current Students > Degree application, Interim review http://www.medphas.kumamoto-u.ac.jp/en/medgrad/gakunai/sinsei/ ＜博士課程4年生及び3年生（甲）/ 4th and 3rd year Doctoral Course ‘甲’＞

事前審査申請締切 Deadline of application of Preliminary review

本審査提出締切 Deadline of Submission

令和2年 9月修了希望者 For graduation in September 2020

令和2年 5月18日（月） May 18 (Mon), 2020

令和2年 6月 5日（金） June 5 (Fri), 2020

令和３年 3月修了希望者 For graduation in March 2021

令和2年11月20日（金） November 20 (Fri), 2020

令和2年12月21日（月） December 21 (Mon), 2020

※通常の修了期以外(6 月・12 月)の修了を希望する場合は、修了予定月の 3 ヶ月以上前に医学教務担当まで申し出 ること。 * Students who prefer to complete in June or December shall inform to student affairs office by 3-month notice.

＜令和元年度単位修得退学者 （甲（遡及）） / For withdrawal in 2019 ‘甲(遡及)’＞ 単位修得退学後、1年以内の方が対象です。You can apply for doctoral degree as ‘甲(遡及)’ if it within one year after you complete coursework without degree.

事前審査申請締切 Deadline of application of Preliminary review

本審査提出締切 Deadline of Submission

令和元年 9月単位修得退学者 For withdrawal in September 2019

令和2年 5月18日（月） May 18 (Mon), 2020

令和2年 6月 5日（金） June 5 (Fri), 2020

令和2年 3月単位修得退学者 For withdrawal in March 2020

令和2年11月20日（金） November 20 (Fri), 2020

令和2年12月21日（月） December 21 (Mon), 2020

＜論文博士・乙 / Doctoral Dissertation ‘乙’＞ 事前審査申請締切

Deadline of application of Preliminary review 本審査提出締切

Deadline of Submission 令和2年度中に学位を取得する場合 For receiving a doctor's degree in AY 2020

令和2年11月20日（金） November 20 (Fri), 2020

令和2年12月21日（月） December 21 (Mon), 2020

＜修士課程/ Master’s Course＞ ※修士課程の場合、事前審査はありません。 * In Master’s Course, there is no Preliminary review.

提出締切 Deadline of Submission

令和2年 9月修了希望者 For graduation in September 2020

令和2年 6月 8日（月） June 8 (Mon), 2020

令和3年 3月修了希望者 For graduation in March 2021

令和2年12月 9日（水） December 9 (Wed), 2020

-26-

【Attachment 1】

Schedule

By 5 p.m. 【Doctoral Course】＊

May 18, 2020 Deadline of Application ◎Submissions can be accepted for Preliminary review at anytime before the deadline. （To Student Affairs office of GSMS）

　

May 25, 2020 Preliminary reviewby Committee Professors

Return the documents for revision◎After preliminary review, the documents will be back

to you. Please revise the places which pointed out by

committee, and prepare for the formal submission.

By 5 p.m. 【Doctoral Course】June 5, 2020 Deadline of formal submission

for Doctoral degree（To Student Affairs office of GSMS）

By 5 p.m. 【Master Course】＊

June 8, 2020 Deadline of Application for Master's degree

（To Student Affairs office of GSMS）

June 17, 2020 Educational committee ◎We officially receive your application and arrange

examiners for final defense.(Public presentation)

Jun 24, 2020 Faculty meeting=First Review=

　　◎Your examiners are decided.

June 26, 2020 ～ As soon as the examiner and schedule of public presentation is confirmed,we will inform it by email.◎Bring a thesis and abstract to your examiners

in person promptly.

July 1, 2020 ～ Public Presentation (Doctoral Course)July 31, 2020 Public Presentation (Master’s Course)

August 26, 2020 Faculty meeting=Second Review=

◎Deliberation your result: pass or fail

Around the early We will announce you result by emailSeptember ◎In accordance with the notification, please submit

necessary data and documents before you graduate.

On September 25, 2020 Completion Ceremony (expected)

＊Including students expected to complete earlier

Degree Application Schedule(For Students who Expected to Complete in September 2020)

Degree Applicant Committee・Faculty Meeting

-27-

【Attachment 2】

Schedule

By 5 p.m. 【Doctoral Course】＊

November 20, 2020 Deadline of Application ◎Submissions can be accepted for Preliminary review at anytime before the deadline. （To Student Affairs office of GSMS）

　

November 26, 2020 Preliminary reviewby Committee Professors

Return the documents for revision◎After preliminary review, the documents will be back

to you. Please revise the places which pointed out by

committee, and prepare for the formal submission.

By 5 p.m. 【Master Course】＊

December 9, 2020 Deadline of Application for Master's degree

（To Student Affairs office of GSMS）

By 5 p.m. 【Doctoral Course】December 21, 2020 Deadline of formal submission

for Doctoral degree（To Student Affairs office of GSMS）

December 25, 2020 Educational committee ◎We officially receive your application and arrange

examiners for final defense.(Public presentation)

January 6, 2021 Faculty meeting=First Review=

　　◎Your examiners are decided.

January 13, 2021 ～ As soon as the examiner and schedule of public presentation is confirmed,we will inform it by email.◎Bring a thesis and abstract to your examiners

in person promptly.

January 27, 2021 ～ Public Presentation (Doctoral Course)February 5, 2021 Public Presentation (Master’s Course)

February ●, 2021 Faculty meeting"Schedule is being adjusted" =Second Review=

◎Deliberation your result: pass or fail

Around the end of We will announce you result by emailFebruary ◎In accordance with the notification, please submit

necessary data and documents before you graduate.

On March 25, 2021 Completion Ceremony (expected)

＊Including students expected to complete earlier

Degree Application Schedule(For Students who Expected to Complete in March 2021)

Degree Applicant Committee・Faculty Meeting

-28-

【Attachment 2】