BACKGROUND

Double-blinded, randomized, 6-days, crossover study

Patients were admitted to the Department of Pediatric Federico II University, Naples Italy

Experimental preparation was given in the same amount of conventional starch according to patients’ diet

Glucose, lactate, venous pH, serum insuline were measured before and after each meal

72h continuous glucose monitoring was performed

The participants were asked to reproduce the everyday life as much as possible

STUDY DESIGN

GSD1aG I 16 yearsI AM 13 years C P 18 yearsR C 12 yearsA L 12,5 years S G 24 years

GSD1bC M 14 yearsM V 14 years M A 25 years O N 30 years

PATIENTS

6 GSD1a

4 GSD1b

AL

1

2

RC

1

2

IAM

1

2

The experimental starch maintained blood glucose concentrations longer than did the traditional therapy in 2/3 GSD1a1/2 GSD1b

The daily amount of starch was reduced in 2/3 GSD1a, 1/2 GSD1b

No significant effect was observed on insulin, lactic acid levels and venous pH

No side effect was observed

…not so tasty

PRELIMINARY RESULTS

RISULTATI

RISULTATI

RISULTATI

CONCLUSIONI

AMIDO FISICAMENTE MODIFICATO VS AMIDO STANDARD

Migliore controllo della glicemia

Maggior riduzione dell’acido lattico plasmatico

Miglior assorbimento con minore fermentazione colica dell’amido non digerito

Nessuna differenza statisticamente significativa del profilo insulinico