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Pre-exposure prophylaxis may be beneficial for people who will be experiencing exposures that

carry a high risk of infection. These include soldiers training in tropicalregions, adventure

tourists who will have freshwater exposure (especially tropical) and veterinarians who will be

working with infected animals. oxycycline at !""mg once for a single exposure or once a week 

throughout ongoing exposure is recommended

(#rown !""$, %uidugli !""", &eymann !""').

ntibiotic post-exposure prophylaxis (e.g. doxycycline at !"" mg) is indicated for persons who

have been exposed to leptospires. &owever, antibiotic prophylaxis is not routinely offered to

 protect owners of animals which have been infected with leptospirosis as the risk of transmission

through normal human contact with animals is considered low (e.g. if there is no physical contact

with the animals urine)

(#rown !""$, &eymann !""').

oxycycline prophylaxis is contra-indicated in pregnant or breast-feeding women and children

under the age of $. s indicated, it may be prudent for these individuals to avoid clean-up of

animal wastes and contact with pets during peak periods of transmission (*-+ weeks after onset).

Prompt antibiotic treatment of human cases can reduce the duration of fever, but may not reduce

mortality. Penicillin is the drug of choice, but alternatives are doxycycline, ampicillin,

erythromycin, cephalosporins and uinalone antibiotics (&eymann !""').

ny suspected case of leptospirosis presenting with acute febrile illness

and various manifestations #T with stable vital signs, anicteric sclerae,

with good urine output, and no evidence of meningismus meningeal

irritation, sepsis septic shock, difficulty of breathing nor /aundice and can

take oral medications is considered 012 23PT45P164515 and can be

managed on an 4T-PT137T 53TT17%. 8%rad e 9

ny suspected case of leptospirosis presenting with acute febrile illness

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associated with unstable vital signs, /aundiceicteric sclerae, abdominal

 pain, nausea, vomiting and diarrhea, oliguriaanuria, meningismus

meningeal irritation, sepsis septic shock, altered mental states or difficulty

of breathing and hemoptysis is considered 0436T3 : 53;363

23PT45P164515 and #35T managed in a &32T&

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E. 5uputtamongkol K, 7iwattayakul G, 5uttinont