44th AnnualBarrow Neurological Institute

Neuroscience Symposium

BARROWNeurological Institute

Tuesday-Friday | May 8-11, 2018Goldman Auditorium

350 West Thomas Road | Phoenix, Arizona

Optional Pre-Symposium Microvascular Bypass Workshop

May 8-9

$75 Discount if you register on or before 4/25/2018

barrowneuro.org/confer-ence/2018neuroscience

FACULTYCourse Directors | Barrow Neurological InstituteTerry Fife, MDDirector, Balance Disorders and Vestibular Neurology ProgramPeter Nakaji, MDDirector, Neurosurgery Residency Program

Michael T. Lawton, MD President & CEO, Barrow Neurological Institute Chair, Department of Neurological SurgeryJeremy Shefner, MD, PhD, FAANChair of Neurology

Allyson Alexander, MD, PhD Assistant Professor University of Colorado Denver School of MedicineM. Ali Aziz-Sultan, MD, MBA Associate Professor, Neurosurgery Harvard Medical SchoolAnne Cress, PhD Professor of Cellular and Molecular Medicine The University of Arizona

Evan Fram, MD, MBA Clinical Professor, Department of Neuroradiology, Retired Bradley Gross, MD Assistant Professor University of PittsburghJohn Hurlbert, MD Professor, College of Medicine University of ArizonaGregory Lekovic, MD Neurosurgeon House Clinic

Kelly Mahaney, MD, MS Assistant Professor Neurosurgery, Pediatric Neurosurgery Stanford UniversityShawn Stevens, MD Otolaryngologist AOC Physicians Krystal Tomei, MD Reinberger Endowed Director in Pediatric Neurological Surgery Rainbow Babies & Children’s Hospital

P. David Adelson, MD Director, Barrow Neurological Institute at Phoenix Children’s HospitalChief, Department of Neurosurgery

Ruth Bristol, MD Assistant Professor, Department of Neurosurgery

Jamal McClendon, MD Pediatric Neurosurgeon

Felipe Albuquerque, MD Director, Division of Endovascular NeurosurgeryKaith Almefty, MD Assistant Professor, Department of NeurosurgeryIgor Barani, MD Director, Artificial Intelligence Center Damian Berezovsky, MD Director of Neuro-Ophthalmology Division Aimee Borazanci, MD Director of Neuro-Immunology and Multiple Sclerosis Fellowship Program Robert Bowser, PhD Chairman, Neurobiology Anna Burke, MD Director of Neuropsychiatry Javier Cárdenas, MD Director, Barrow Concussion and Brain Injury CenterSteve Chang, MD Assistant Professor, Department of NeurosurgeryTsinsue Chen, MD Chief Neurosurgery Resident Christopher Dardis, MD Assistant Professor, Neurology Neuro-Oncology Division Andrew Ducruet, MDAssistant Director, Division of Endovascular NeurosurgeryTomoki Hashimoto, MD Professor, Neuroanesthesia and Neurobiology U. Kumar Kakarla, MD Assistant Professor, Department of NeurosurgeryJohn Karis, MD Director, MRI & Brain Imaging

Brian Kelly, PhD Assistant Professor, Neurobiology Kerry Knievel, DO Director of In-Patient Neurology Michaela Lee, MD Cerebrovascular & Skull Base Fellow Brandon Liebelt, MD Cerebrovascular & Skull Base Fellow Andrew Little, MD Director, Barrow Interdisclinary Skull Base Team & Pituitary Center Justin Macitelli, MD Cerebrovascular & Skull Base Fellow Zaman Mirzadeh, MD, PhD Assistant Professor, Department of NeurosurgeryGuillermo Moguel-Cobos, MD Associate Professor of NeurologySuraj Muley, MD Director of Neuromuscular Diseases CenterRory Murphy, MD Neurosurgeon Surasak Phuphanich, MD Director, Department of Neuro-Oncology Francisco Ponce, MD Director, Barrow Center for Neuromodulation Randall Porter, MD Director, Interdisciplinary Skull Base Program SurgeryMark Preul, MD Newsome Chair, Neurosurgery ResearchChad Quarles, PhD Associate Professor, Imaging Research C. Leland Rogers, MD Radiation Oncologist

Nader Sanai, MD Director, Division of Neurosurgical OncologyHolly Shill, MD Director, Muhammad Ali Parkinson CenterKris Smith, MD Medical Director, Gamma KnifeLaura Snyder, MD Assistant Professor, Department of NeurosurgeryDavid Treiman, MD Director of Epilepsy CenterLuis Tumialan, MD NeurosurgeonJay D. Turner, MD, PhD Assistant Professor, Department of NeurosurgeryJuan Uribe, MD Chief , Spinal DisordersJohn Wanebo, MD Director, Moyamoya Center Michael Waters, MD Director, Neurovascular Division and Stroke Program Jina Youn, MD Assistant Professor of NeurologyKevin Yuen, MDMedical Director, Barrow Pituitary CenterEmad Youssef, MD Assistant Professor, Department of Radiation OncologyJoseph Zabramski, MD Chief, Division of Cerebrovascular SurgeryGlynnis Zieman, MD Assistant Professor of Neurology Concussion and Brain Injury Center

Guest Faculty

Barrow Neurological Institute at Phoenix Children’s Hospital Faculty

Senior Distinguished Faculty | Barrow Neurological Institute

Faculty | Barrow Neurological Institute

Robert F. Spetzler, MD Emeritus President & CEOEmeritus Chair, Department of Neurological Surgery

AGENDA | Tuesday - Friday, May 8-11, 2018PRE-SYMPOSIUM MICROVASCULAR BYPASS WORKSHOP (Optional) | May 8-9 | Goldman AuditoriumTuesday, May 8th12:00 PM Registration and Lunch1:00 PM Welcome Joseph Zabramski, MD Overview of EC-IC/IC-IC Bypass Michael Lawton, MD Low-Flow Bypass Applications and Techniques Joseph Zabramski, MD1:45 PM Break and Move to Laboratory2:15 PM Hands-On Training with Silastic Tubing and Turkey Wing Arteries Joseph Zabramski, MD Michael Lawton, MD Peter Nakaji, MD5:15 PM AdjournmentWednesday, May 9th7:00 AM Registration and Continental Breakfast7:30AM High Flow Bypass Principles, Applications, and Techniques Peter Nakaji, MD Bypass for Moyamoya Disease John Wanebo, MD Bypass Case Review Robert Spetzler, MD8:30 AM Break and Move to Laboratory9:00 AM Hands-On Training with In Vivo Rodent Model and Placenta Models Joseph Zabramski, MD Peter Nakaji, MD John Wanebo, MD12:00 PM Adjournment

44th ANNUAL BARROW NEUROSCIENCE SYMPOSIUM | Wednesday | May 9 | Goldman Auditorium12:00 PM Registration12:50 PM Welcome Michael Lawton, MD 1:00 PM Trauma Controversies in Neurotrauma: Are We Doing Enough? Laura Snyder, MD The Road to Recovery: The Impact of the Barrow Concussion Javier Cardenas, MD and Brain Injury Center Surgical Decision Making in TBI and SCI Rory Murphy, MD The Injured Who Stay Silent: Traumatic Brain Injury in Domestic Glynnis Zieman, MD Violence Survivors Neurotraumatic Sports Injuries: Treating the Professional Players Randall Porter, MD and Those Who Want to Be Practice and Management of Spine Trauma Close to the Border John Hurlbert, MD2:30 PM Break2:45 PM Imaging and Innovation Primer on Non-Cartesian MR Imaging - New Spiral Scans at the BNI John Karis, MD Artificial Intelligence (AI) Primer Igor Barani, MD Dynamic Contrast Imaging (Glial Tumors) C. Chad Quarles, PhD Image Perception and Information Overload Evan Fram, MD, MBA Meningioma Clinical Trials Leland Rogers, MD Dedicated ED MR Imaging at the BNI John Karis, MD Barrow Aneurysm and AVM Center Tomoki Hashimoto, MD5:05 PM Adjournment5:15 PM Welcome Reception – Faculty and Attendees

44th ANNUAL BARROW NEUROSCIENCE SYMPOSIUM | Thursday | May 10 | Goldman Auditorium7:00 AM Registration and Breakfast7:50 AM Welcome8:00 AM Spine MIS Deformity: The Wave of the Future Juan Uribe, MD Open Correction: The Time Proven Gold Standard Udaya Kakarla, MD Debate - Discussion Evaluating Strain in Spinal Instrumentation: Brian Kelly, PhD Are Standardized Test Methods Enough? Optimizing Lumbosacral Biomechanics in Long Segment Constructs: Jay D. Turner, MD, PhD Cadaveric Analysis of Rod and Screw Strain MIS TLIF: Indications and Applications Laura Snyder, MD The Minimally Invasive Lumbar Laminectomy Luis Tumialan, MD Robotics in Spine Steve Chang, MD10:00 AM Break 10:15 AM Pediatric Neurosciences Innovations in Epilepsy Surgery P. David Adelson, MD The Promise of Optogenetics in the Study and Treatment of Epilepsy Allyson Alexander, MD, PhD

Management of the Severely Deformed Spine Jamal McClendon, MD Advances in Treatment Strategies for Complex Syndromic Craniosynostosis Krystal Tomei, MD, MPH Trends in Pediatric Hydrocephalus Kelly Mahaney, MD, MS Considerations in Treatment of Pediatric Brain Tumors Ruth Bristol, MD12:00 PM Lunch Provided1:00 PM Functional Neurosciences Update: Barrow Center for Neuromodulation Francisco Ponce, MD Update: Mohammad Ali Parkinson’s Center Holly Shill, MD Neurosurgical Management of Pain Zaman Mirzadeh, MD, PhD Future of ALS Therapies Robert Bowser, MD Use of Intraoperative Electrocorticography for Parkinson’s Disease Research Tsinsue Chen, MD Current Therapeutics for Dystonia Guillermo Moguel-Cobos, MD Advancing Brain and Spinal Cord Injury Care Rory Murphy, MD2:45 PM Break3:00 PM Skull Base Surgery Treatment Paradigms for Chordoma & Clinical Trial Update Andrew Little, MD Emerging Treatment Targets for Chordoma Anne Cress, PhD Diabetes Insipidus and Obesity in Craniopharyngioma: Kevin Yuen, MD Neuro-Endocrinology Concerns Practical Management of Giant Acoustic Neuromas Randall Porter, MD Nonvestibular Schwannomas Kaith Almefty, MD Hearing Preservation Considerations in Lateral Skull Base Surgery Shawn Stevens, MD Endoscope-Assisted Acoustic Neuroma Surgery Greg Lekovic, MD4:45 PM Adjournment44th ANNUAL BARROW NEUROSCIENCE SYMPOSIUM - Concurrent Programs | Friday | May 117:00 AM Registration and Breakfast7:50 AM Welcome Michael T. Lawton, MDNeurosurgery Breakout Session | Goldman Auditorium8:00 AM Vascular and Stroke BNI Endovascular Stroke Update Andrew Ducruet, MD Management of Complex DAVFs Felipe Albuquerque, MD Technical Nuances of AVM Surgery Michael Lawton, MD Aneurysm Surgery and BRAT Robert Spetzler, MD Cerebrovascular Radiosurgery in 2018 Peter Nakaji, MD Update on the Barrow Emergency Stroke Treatment Unit Michael Waters, MD, PhD Acute Ischemic Stroke Management Jina Youn, MD Endovascular Case Presentation M. Ali Aziz-Sultan, MD Old Tricks for New Dogs: Applications for Thrombectomy Bradley Gross, MD and Intracranial Stenting10:15 AM Break10:30 AM Tumors A Phase 0/II Drug Discovery Program Nader Sanai, MD Radiotherapy Innovations for Brain Tumors Igor Barani, MD Update on Immunotherapy Clinical Trials Surasak Phuphanich, MD Laser Ablation Strategies for Brain Tumor Patients Kris Smith, MD Brachytherapy Emad Youssef, MD Clinical Trials Update for Gliomas Christopher Dardis, MD Neurology Breakout Session | Sonntag Pavilion8:00 AM Cognitive Disorders Anna Burke, MD Rational Polytherapy for Epilepsy David Treiman, MD Options for Intractable Migraine Headache Kerry Knievel, DO Newer Treatments Strategies in Immune Mediated Neuromuscular Disorders Suraj Muley, MD10:00 AM Break10:30 AM Update on Treatment of ALS, SMA Jeremy Shefner, MD, PhD, FAAN Update on MS Treatment Aimee Borazanci, MD Optic Neuropathy Damian Berezovsky, MD12:00 PM Adjournment Agenda is subject to change

WHO SHOULD ATTENDNeurosurgeons, neurologists, residents and other healthcare providers with an interest in the application of best practices in the evaluation and appropriate treatment of patients with aneurysms, neurodegenerative diseases, various causes of stroke and utilizing DBS to treat Alzheimer’s disease.SYMPOSIUM OBJECTIVES1. Discuss the role of extracranial-intracranial bypass

techniques as well as their relevance in the treatment of occlusive cerebrovascular disease.

2. Cite the newest research findings and provide up-to-date protocol for concussions.

3. Describe the benefits of stem cell transplants and treatment for brain tumors and ALS.

4. Discuss the changes in the treatment of epilepsy as it relates to both neurosurgery and neurology.

44th ANNUAL BARROW NEUROSCIENCE SYMPOSIUM

Registration Form44th Annual Barrow Neuroscience Symposium | May 8-11, 2018

Register Early! Take advantage of discounted registration fees. Early Bird Registration Pre and Onsite Registration Deadline 4/25/18 After 4/25/18 Pre-Symposium Microvascular Bypass Workshop (Limited to 20 participants)Tuesday-Wednesday | May 8-9, 2018 Physician $600 $675Resident / Fellow $200 $275 Barrow Neuroscience SymposiumWednesday - Friday | May 9-11, 2018 Physician $350 $425Resident/Fellow $125 $200NP / PA / CNRN $250 $325 Alumni $275 $350

Registration fee includes: Symposium, continental breakfast, lunch (when noted), Welcome Reception, program materials and continuing education credits.

Refund and Cancellation Policy: A refund, less 20% processing fee, will be made for cancellations submitted in writing prior to April 25, 2018. No refunds will be made thereafter. Barrow reserves the right to cancel or change any program for due causes. Cancellation of a program by Barrow will result in a full refund of tuition. Barrow and SJHMC are not responsible for the refund of travel or hotel expenses under any circumstances.

REGISTER NOWhttps://www.barrowneuro.org/conference/2018neuroscience/

For more information, please contact the Barrow Continuing Medical Education Office at CME@BarrowNeuro.org or 602-406-3067.

Visiting Arizona

What to do in ArizonaArizona is known for its natural beauty and outdoor adventures. It’s also home to a bustling metropolitan with some of the world’s finest chefs, shopping and nightlife. Whether you explore Downtown Phoenix, Scottsdale or other surrounding cities, your stay will be filled with memorable experiences. To learn more about the Phoenix area, visit visitphoenix.com or experiencescottsdale.com.

DressDress for all sessions is business casual. Temperatures in Phoenix in April average from 86 degrees during the day to 63 degrees at night. Please keep in mind that meeting room temperatures vary, so wear layered clothing to ensure your comfort.

AccreditationSt. Joseph’s Hospital and Medical Center is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.DesignationSt. Joseph’s Hospital and Medical Center designates this live activity for a maximum of 22.50 AMA PRA Category 1 CreditsTM. Physicians should only claim credit commensurate with the extent of their participation in this activity.

350

Wes

t Tho

mas

Roa

dPh

oeni

x, A

Z 85

013

Non

prof

it O

rg.

U.S

. Pos

tage

PAID

Perm

it N

o. 6

85Ph

oeni

x, A

rizon

a

St. J

osep

h’s

Hos

pita

l and

Med

ical

Cen

ter

- Ja

nuar

y 20

12St

. Jos

eph’

s H

ospi

tal a

nd M

edic

al C

ente

r -

Janu

ary

2012

St. J

osep

h’s

Hos

pita

l and

Med

ical

Cen

ter

- Ja

nuar

y 20

12os

eph’

s H

ospi

tal a

nd M

edic

al C

ente

r -

Janu

ary

2011

StJ

h’H

itl

dM

dilC

tJ

2012

pp

y

Thom

as R

oad

Earll

Driv

e

Cata

lina

Driv

e

Mer

rell

Stre

et

Mercy Way y Mercy Way

7th Avenue

1st Avenue

6th Avenue6th Avenue

3rd Avenue

5th A

venu

e

5th A

venu

e

St. J

osep

h’s

and

Bar

row

Foun

datio

n O

ffic

es

St. J

osep

h’s

Cent

er fo

rEd

ucat

ion

& D

evel

opm

ent

Suite

132

Dig

nity

Hea

lthCo

rpor

ate

Phoe

nix

3rd

Aven

uePa

rkin

g G

arag

e

Patie

nt V

isito

r Par

king

6th

Aven

uePa

rkin

g G

arag

e

Park

ing

Lot J

Que

stLe

arni

ngCe

nter

Pepp

ertr

eeB

uild

ing

Gas

light

Bui

ldin

g

Pool

McA

uley

Off

ice

Bui

ldin

g

Vale

tPa

rkin

g

Bar

row

Neu

rosc

ienc

eTo

wer

Patie

ntTo

wer

Anci

llary

Bui

ldin

g

Conf

eren

ceCe

nter

Chap

el

Radi

atio

nOn

colo

gy

Mai

n B

uild

ing

MR

IB

uild

ing

Heart

& Lung

Tower

3rd

Aven

ue B

ridge

NeuroscienceResearch Center

240

Lonn

ie &

Muh

amm

ad A

liPa

vilio

n

Outp

atie

ntSu

rger

y &

Neu

roRe

habi

litat

ion

222

Med

ical

Off

ice

Bui

ldin

gPh

arm

acy

Hum

anR

esou

rces

Empl

oyee

Hea

lth

124

Child

ren’

sR

ehab

ilita

tive

Serv

ices

114

Out

patie

ntR

ehab

ilita

tion

Patie

nt V

isito

rPa

rkin

g Hos

pita

lM

ain

Entr

ance

Gold

man

Aud

itoriu

mEn

tran

ce o

n 3r

d Av

enue

Emer

genc

yEn

tran

ce Vale

tPa

rkin

g

Reg

iste

r N

ow!

$75

DIS

COU

NT

expi

res

April

25,

201

8

barr

owne

uro.

org/

conf

eren

ce/2

018n

euro

scie

nce