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1 Basic Mechanism for Auto-Urine Therapy: Information in the urine and its control / action mechanism By Yoshitane Ueda ([email protected].jp) In order to treat abnormal metabolism, it is essential to restore the abnormal state of metabolites to a constant (normal) state. There are several metabolites withi n the urine that reflect the condition of the body. Treatment of abnormal metabolism will be possible if the information on abnormal metabolites in the urine can be carried back to stimulate negative feedback control via the hypothalamic region in the brain. Jan. 12, 2004 First Publication Jan.20, 2006 Fi fth Revision Introduction Auto-urine t herapy is also known as “urine therapy” or health management with urine and is a simple therapy of merely “drinking one’s own urine ”. Urine has a wide range of benefits certainly for clinical conditions such as infectious diseases, but also for chronic il lnesses, visceral diseases, cancers, skin diseases, and toothaches. It is also effect ive for health maintenance, beauty, and di eting. Bearing a 5000-year history with records and backed by an accumulation of human experiences, it is known to be a safe, tradit ional therapy. However, the therapeutic mechani sm remains to be a mystery. The purpose of this paper is to scientifically clarify the mystery. The practice of drinking urine requires courage to overcome one’s own disgust and prejudice. My hope is that the scie ntific clarification of urine therapy will help one make a rational decision towards practicing this therapy. 1. Urine is the Final Substance of Information from the Body Urine production takes place in the kidney but prior to that it is blood, and even prior to that it is a metabolite produced by various organs in the body. If a metabolite can be called “informational substance”, urine is the storehouse of “final informational substances ”. A wide variety of metabolites such as biochemical substances, antibodies, hormones, enzymes, and proteins exist as informational substances in urine. The daily fluc tuation of urine composition is significant, where the concentration change is most consi derable. The analytical values can progressively degenerate and modify by the minute because of factors such as contamination due t o sampling, oxygen, heat, or light. It is also easily influenced my medication. If t here are medicinal substance s i n the urine, they may change other substance s as well. The timing of the fluctuation of urine composition and the manifestation of abnormal metabolism is not always the same. The data is often poorly reproducible and the boundary between normal and abnormal i s unclear. Furthermore, even a general urine composition can be influenced by diet and environment and vary between ethnicities.

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Basic Mechanism for Auto-Urine Therapy:I nfor mation in the urine and its control / action mechanism

By Yoshitane Ueda([email protected])

In order to treat abnormal metabol ism, it is essential to restore the abnormal state ofmetabol ites to a constant (normal) state. There are several metabol ites within theurine that reflect the condi tion of the body. Treatment of abnormal metabol ism willbe possible if the information on abnormal metabol ites in the urine can be carriedback to stimulate negative feedback control via the hypothalamic region in the brain.

Jan. 12, 2004 First PublicationJan.20, 2006 Fifth Revision

I ntr oductionAuto-urine therapy is also known as “urine therapy” or heal th

management with urine and is a simple therapy of merely “drinking one’s ownurine”. Urine has a wide range of benefits certainly for cl inical condi tions such asinfectious diseases, but also for chronic il lnesses, visceral diseases, cancers, skindiseases, and toothaches. It is also effective for health maintenance, beauty, anddieting. Bearing a 5000-year history with records and backed by an accumulationof human experiences, it is known to be a safe, traditional therapy.

However, the therapeutic mechanism remains to be a mystery. Thepurpose of this paper is to scientifical ly clarify the mystery.

The practice of drinking urine requi res courage to overcome one’s owndisgust and prejudice. My hope is that the scientific clarification of urine therapywill help one make a rational decision towards practicing this therapy.

1. Urine is the Final Substance of I nfor mation from the BodyUrine production takes place in the kidney but prior to that it is blood, and

even prior to that it is a metabol ite produced by various organs in the body. If ametabol ite can be called “informational substance”, urine is the storehouse of “finalinformational substances”. A wide variety of metabol ites such as biochemicalsubstances, antibodies, hormones, enzymes, and proteins exist as informationalsubstances in urine.

The dai ly fluctuation of urine composi tion is significant, where theconcentration change is most considerable. The analytical values can progressivelydegenerate and modi fy by the minute because of factors such as contamination dueto sampl ing, oxygen, heat, or light. It is also easi ly influenced my medication. Ifthere are medicinal substances in the urine, they may change other substances aswell . The timing of the fluctuation of urine composi tion and the manifestation ofabnormal metabol ism is not always the same. The data is often poorlyreproducible and the boundary between normal and abnormal is unclear.Furthermore, even a general urine composi tion can be influenced by diet andenvi ronment and vary between ethnici ties.

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2. Urine is Absorbed in the Body through Skin / Membr ane

Metabolites contained in dai ly urine are often of infinitesimal quantity asmicro, nano, or pico levels. In addi tion, since the dai ly urine consumption is 100 ccto 200 cc, al l the more.

In addi tion to the smal l quantity of this in urine, metabol ites are affected byoxygen, light, and heat, and furthermore once they enter the stomach most of themare degenerated and modi fied by “stomach acids”. By the time urine metabol itesreach the smal l intestine for absorption, there is a definite reduction in theremaining metabol ites that have not been degenerated or modi fied. Anypharmacological effect cannot be expected from such trace quantity.

Yet, those that practice urine therapy claim that there stil l are benefits. Infact, there are therapeutic effects reported with even “less urine”. Such examplesare:

“A person survived being adri ft at sea for a long period, by licking his urine”(Other sailors had perished).

“By gargl ing with urine, one achieved the same benefits as drinking urine”.This perhaps is the greatest mystery of urine therapy.If these reports are taken as facts, the only common site involved in

“drinking urine”, “ l icking urine” and “gargling with urine” is the oral cavity.Following logic, “Information obtained from the urine composi tion is al readyabsorbed in the body through cells / membrane of the oral cavity” . This iscorroborated by the fact that the osmotic pressure of urine is twice as high comparedwith other bodily fluids.

“Drinking urine” is an expression that depicts an il lusion of urine beingabsorbed in the stomach / smal l intestine much like internal medicine. At the sametime, the general term “urine” can be interpreted as not only one’s own urinebut also the drinking of other people’s urine, or animal urine (biological informationof others). In order to avoid any unnecessary confusion, we would like to give it amore speci fic name: “Auto-urine therapy” (Health management with auto-urine).

Treatment Through The Hypothalamic Region

1. Feedback ControlIn discussing the role of urine as a col lection of “ information”, the idea of

“information and control / adjustment” or the concept of “Cybernetics”, as theysay in the automatic control theory in engineering, must be mentioned. Incybernetics, the action mechanism consists of a “Feedback Control System”.Generally in feedback control, part of the output is sent back to the input of thesystem and becomes part of the signal , thus controll ing the output of the system as“feedback”. The following block diagram describes this model.

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The signal from the controller is sent to the controlled system but the outputof the system gets restricted due to external disturbance that puts things off balanceand causes interference. This output is detected by the signal converter, and thesystem output is converted to a feedback signal , which is then sent to a error detector.At this point, the ini tial first control signal and feedback signal are compared and aresent to the controller as error signals. The error is fixed at the controller and inputto the controlled system is controlled. In other words, the Feedback signal value(Uxf) is compared with the desired value of the control signal (Uxd) and the errorvalue (Uxe) is detected as: Uxe = Uxf – Uxd.

If Uxd > Uxf, then an error signal is expressed as Uxe < 0. And if Uxt < Uxf,then it is expressed as Uxe > 0. In other words, the error signal is opposite indirection to the feedback signal . When one refers to feedback, it is generallyconsidered negative feedback.

The characteristic of this type of envi ronmental control is that the originalcause cannot be controlled in advance based on a predicted outcome. Moreover, atime “delay” is inevitably generated between the original cause and the nextoperation load. Consequently a “deviance” can be generated between the controlload and next operation load. At times, this deviation can connect to excessivecontrol and convert to “positive feedback”.

This idea is the basis of physiology and also an important conceptualfoundation for the action mechanism of the body’s homeostasis.

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2. Function of the Hypothalamus / Homeostasis of the Body

From the perspective of the entire brain, the hypothalamus, along with thebrain stem, is the pil lar of the brain and is located in its central part. The functionof the hypothalamus is humoral control of the endocrine apparatus to the splanchnicorgans/muscles through the pituitary gland using peptide hormones. In this way,the pituitary gland governs the entire body.

The hypothalamus and brain stems regulate the splanchnic organs/musclesthrough the autonomic nervous system (sympathetic/parasympathetic nerves).

The hypothalamus, mediated by the spleen, regulates the activi ty of theimmune system.

The hypothalamus connects with the brain cortex and limbic cortex toadjust the emotional function in the psychological and sensory areas.

The hypothalamus is projected onto the brain stems, which is associatedwith appetite and awareness. For instance, brain stems, mediated by the basalgangl ion and the motor area, adjust motor activi ty by connecting to thecerebel lum.

As shown above, various control functions related to li fe maintenance isconcentrated in the hypothalamus and this conducts comprehensive informationprocessing (maintaining homeostasis).

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Li fe is maintained at a dynamic constant state by the body’s internalenvi ronment. The cells that consti tute the body are al l involved in maintaining thishomeostasis. This is true even at the individual cell level. What supports this is thebody’s feedback system. The fact that the body’s internal envi ronment is at aconstant state means that if there is over activi ty in an organ’s function, it will besuppressed and if there is a lack, it will be stimulated. This kind of automatedregulation mechanism (negative feedback) exists throughout the body. In a healthyperson, a smal l disturbance in value will fal l within a permissible range and can beself-repaired by the automated regulation system.

3. Basic Action Mechanism of the Feedback System and the Auto-UrineTherapy

When food is taken in through the mouth, humoral regulation feedback inthe oral cavity begins and from there on, this system is repeated many times in eachorgan. In the last stage, part of the original urine produced by the glomerulus ofthe kidney is absorbed in the path leading to the bladder by the renal tubules. Thisis the final feedback stage that takes place in the body. The concentrated originalurine is excreted from the body as “urine” and normally leaves the feedback system.

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Homeostasis, as long as one is healthy, is fully maintained by this feedback systemin the body alone.

However, whenever there is an abnormality in the body or a “pathologicalcondi tion” , this information is disseminated in the urine as a metabol ite.Metabolites in the urine carry abnormal values (abnormal metabol ites). Thesepathological condi tions are also known as an “abnormal ____ metabol ite disorder”by bearing the name of the metabol ite or an “abnormal ____ metabol ite syndrome”referring to a group of pathological condi tions.

Abnormal ity in the urine metabol ites is detected in the oral cavity. If thiscan be communicated as a signal /information to the hypothalamus via the thalamus,a regulation command to fix the abnormal metabol ism can be induced by thehypothalamus upon comprehensive read justment. This is the “basic actionmechanism of auto-urine therapy”.

The urine (output) taken in oral ly is in fact the internal body’s finalinformation being reabsorbed (input) by cells in the oral cavity after once beingexternal information. In other words, it provides for the “body’s feedbacknetwork” .

The limitations of the benefits of auto-urine therapy is the same as thelimitations of the functions of the “body’s feedback system” which centers on thehypothalamus.

Feedback of I nformational Substances (Metaboli tes) in the UrineIt is actual ly difficult to understand from the outside how information is

processed in the hypothalamus and hard to interpret in terms of clear values.Instead, using the numerical information of the urine substances (metabol ites) asindicators at the cl inical level (moni toring), is easier. Since here, we are discussingthe “maintenance of homeostasis”, we will refer to these indicators as“homeovalues” . Furthermore, we will refer to the values that indicate pathologicalcondi tions / abnormal metabol ism as “abnormal values”. Abnormal values willhave “high values” and “low values” with the “homeovalues” in between.

From that standpoint, in auto-urine therapy, “the goal of regulating thesystem, restore the abnormal value of the metabol ite to homeovalue” (treatment),* isachieved though the provision of urine (information of metabol ites).

* Urine analysis is used for “ the determination of pathological condi tions based on abnormal values of themetabol ites” (diagnosis). The goal of auto-urine therapy is just the opposite of this. Terms used in urineanalysis are different, where homeovalue is referred to as a “normal” or “standard” value while in feedbackcontrol theory, i t is called a “desired” value.

Negative feedbackMore speci fically, if an abnormal value of a speci fic urinary metabol ite

was:(1) High (excessive), homeovalue can be restored by “promoting metabol ism orsuppressing production”.(2) Low (lacking), homeovalue can be restored by “suppressing metabol ism orstimulating production”.

This process consti tutes an indicator for a treatment process based on a

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speci fic “negative feedback” control by urinary metabol ites.

When one continues with auto-urine therapy, there are times during theadjustment process when a low abnormal value trying to return to a homeovalue,surpasses the homeovalue range instead of reaching and remaining there, and goes toa higher value. This is a temporary phenomenon that always occurs in thetreatment process due to over-regulation caused by a time lag in the body’sinformation system. This biological phenomenon that is seen as a result of over-regulation is also called “favorable reaction” in Oriental medicine. When afavorable reaction occurs, one reportedly experiences “feelings of exacerbation,fatigue, discomfort, exhaustion, depression, irri tabi lity, nausea, and diarrhea” .Normal ly a reversal occurs and homeovalue is eventual ly achieved (Positivefeedback).

4. Sensor System (1) Sensor Function

There are two functions that can be thought to detect information signals:

a) BiosensorIn general, a sensor that is used to detect chemical substances is called a

chemical sensor. These chemical sensors comprise two sites: one thatrecognizes the chemical substances and another that converts changesgenerated from the first site to electrical signals.

Urinary metabol ites are also absorbed by coming in contact with cells and areconverted to electrical signals, which are then communicated to the hypothalamusvia the central nervous system and thalamus.

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b) Sensor cellsThe other route involves communication via humoral substances where

cells act as sensors simi lar to urinary hormones. These cells are called“sensor cells” and information is transmitted to them which are thencommunicated to the hypothalamus via the thalamus.

(2) Recognition by the Sensor System and its SitesThe homeovalue of the osmotic pressure of urine is 500 – 800 mosm/kg

H20. In contrast, the osmotic pressure of much of the bodily fluids is 275 – 295mosm/kg H20. Since the osmotic pressure of urine is approximately twice that ofother bodily fluids, urine has characteristics that are easi ly absorbed by cells in thebody.*

Since the merits of the sensor system primarily involve the merits of therecognition site, any site that obstructs absorption must be avoided.

Absorption by healthy skin and epidermis is especially bad as well as slow.The partition coefficient of the epidermis’ lipid/water is large and non-dissociative.This is because the epidermis functions as a lipid barrier. However, because ofstructural characteristics of the stratified epi thel ium, the absorption takes a long timeunlike a simple lipid barrier. In contrast, most chemical substances easi ly passthrough the mucous membrane and dermis with a fast absorption rate.

There are three absorption modes:a) Transmucosal Absorption

This is an administration method using absorption via the “mucousmembrane”, a site from which highly precise regulatory results can beexpected. It is more accurate, with a fast absorption rate, and contributes tothe body’s overall regulation.

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i) Administration of the urine by absorption via the “oral mucousmembrane”.

Take in a mouthful of urine and keep it in the oral cavity forabout 30 sec. to 1 min. to maintain ample contact with the mucouscells. During this time, rinse and gargle well . Then, spit the urineout. Wai t for the absorption of the remaining urine in the oral mucousto complete without rinsing.

Since urinary metabol ites are easi ly affected by the external envi ronment,it is important to promptly drink the urine col lected in a cup without leaving it outfor a time, to achieve accurate information. Furthermore, the cup used must be thetype that is stable with acid/alkal i such as glass, ceramic, and paper. Do not usemetal cups.

As the name indicates, most people who practice urine therapy ‘drinkurine’ . It is bel ieved that drinking a lot of urine and maintaining ample contact inthe oral mucous membrane is basically equal in effectiveness. However, it isessential to watch the pH of the urine in this case. There is no problem if the urineis on the alkaline side, as the neutralizing effect by the stomach acid (Informationdestroying effect) will take affect; but if the urine is on the acidic side, an excessiveburden will be put on the stomach.

ii ) Absorption by injecting urine in the “nasal mucous membrane”.This is appl icable for people who are unconscious or people

with sinus infection. In addi tion, it is also appl icable at othermucous membrane sites such as the “eyes”, “ears”, “rectum” and“alveus”.

b) Transdermal absorptionIn the case of skin disorders such as inflammation of the face or hai r root,

topical appl ication, bathing, or wet compression with urine can be used topromote absorption. The absorption takes awhile, (generally about 10 min.).It is appl icable for beautifying effects and treating localized disorders.

c) Subcutaneous absorptioni) Urinary absorption from damaged epidermal sites such as “bruises”or “burns” is fast. Topical appl ication, bathing, or wet compressionwith urine can be used to promote absorption.ii ) Urine is absorbed by subcutaneous injection. This al lows forabsorption of urine directly from the “dermis” or even beyond that.The urine absorption rate is faster than that of the mucous membrane.

* Each component that exists in urine was produced after going through the kidney’s fil ter selectively. It cantherefore easi ly pass through the mucous membrane again. Even though specific microbes may be found inurine as in urinary tract infection (Mycobacter ium, N. gonorrhoeae, Salmonella, Leptospi ra, Mycoplasma,Ureaplasma, Chlamydia, T. vaginal is), they multiply wi thin the urinary tract outside of the kidney andtherefore do not enter the oral mucous membrane.

Blood (eg. menstrual blood) and protein that are mixed into the urine from the outside are notabsorbed by the mucous membrane.

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(1) There are some “homeovalues” themselves in the table above that“fluctuatedai ly”. Clinical condi tions appear and abnormal values are seen, but depending onthe time period, the numerical value of the homeovalue itself at the same time movescloser to the abnormal value. Consequently the difference between thehomeovalue and the abnormal value is not recognized as significant and thefeedback control is not induced. In this case, the time period can be moved so thatthe urine can clearly recognize the difference from that of the homeovalue.

(2) The fluctuation period of abnormal urinary metabol ites and the manifestationperiod of abnormal metabol ism may not always match. In auto-urine therapy, thetreatment effect of a cl inical condi tion is seen only after abnormal values appear inmetabol ites.*

(3) We expect more new urinary metabol ites to be discovered in the future. Inaddi tion, among those known abnormal urinary metabol ites, correlation to othercl inical condi tions may be found. As the correlation between abnormal urinarymetabol ites and cl inical condi tions continues to be investigated, that on its own maybecome the evidence that will broaden the range of benefits of auto-urine therapy.

(4) Treatment by auto-urine therapy cannot be dispensed just because thepathological condi tions and abnormal metabol ites that define the condi tion are notunderstood. Since primitive times, abnormal metabol ites responded to manyunknown pathological condi tions and have been recognized immediately by thehypothalamus, upon which information was automatically processed and regulated.

* Auto-urine therapy is a so-called “ fol low-up” treatment method meaning that i t is not applicable for preventionprior to the mani festation of clinical symptoms. For instance, unl ike immunization wi th vaccine, i t is not usedto bui ld immunity in a heal thy person before he is infected by an infectious disease. This is because there areno abnormal metabol ites (antibodies) in a heal thy person’s urine. In auto-urine therapy, the body tries tomaintain i ts homeovalue and i t can be said that this action constitutes the resistance/prevention againstpathological condi tions. However, needless to say for disease prevention, i t is more important to prevent“external disturbance” rather than depend whol ly on auto-urine therapy--that is, protecting and maintaining agood hygienic environment, such as a heal thy mind, a good diet, water, air, exercising, and sleeping.

ConclusionAn injured animal instinctively licked its own urine that col lected in a smal l

hole.Since primitive times, man put his own urine in a container and drank it.Even today, a baby in the womb drinks his/her own urine from the amniotic

fluid and waits for the day of his/her birth.Since primitive times as well as in modern times, “the origin of medicine”

for li fe began by administering one’s own urine into one’s own mouth.Auto-urine therapy, which was thought to be even primitive, is in fact an

informational treatment method in which the function of the hypothalamus inside thebrain is controlled. It automatically responds to unknown pathological condi tionsand can even be a safe and advanced remedy for the next generation.

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Note: "Information processing that brain and nervous system do and the model" Brain and Computer 5.

Gen Matsumoto・ Noriyuki Ohtsu edi ted. Issued Baifukan(Japan) Only basic textbook type information was extracted in this paper and new theories have not been included.Therefore, I have taken the l iberty of omitting all reference.

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