Basic values of ozone-therapy - HUMARES GMBHhumares.de/files/fallbeispiele/basic-values-of-ozone-therapy.pdf · Treatment of chronic Hepatitis by hyperbaric O3 therapy 18 transminases

Basic values of ozone-therapy by Dr. med. Horst Kief

Presentation in Istanbul Okt 2012

2

0

100

200

300

400

500

600

700

k

c

a

l

Energy gain in the brakedown of fermentation

compared to the energy gain in oxygen metabolism

anaerobic glycolysis O2-metabolism

H. Kief Istanbul 2012

3

Anti-osmosis filtrate

fauced water

aqua bidist.

0

50

100

150

200

250

300

350

400

0 5 30 60 90 120

mm

Hg

time (min)

Oxygenpartial pressure determination

of different water qualities

0 = blank value


4

Anti-osmosis filtrate

faucet water

Aqua bidist.

0

100

200

300

400

500

600

700

800

900

1000

0 5 10 15 20 25 30 60 90 120

mV

Redox potential (mV)

of different water qualities

24 müg ozon concentration0 = blank value

time (min)


5 H. Kief Istanbul 2012


7

0,515

-0,318

0,626

-0,602

0,25

-0,629

0,672

-0,52

0,265

-0,208

-0,8

-0,6

-0,4

-0,2

0

0,2

0,4

0,6

0,8

D0 D1 D2 D3 D4

D0 - D4 = Dulutions in powers of 10 of an erythrocyte lysate by ozonolysis

Change of redox equivalents under different O3- therapies

time between application and control :1 hour

n = 60


8

n = 140 n = 8

029 = 02-03 i.m.Injection

n = 26

-0,6

-0,4

-0,2

0

0,2

0,4

0,6

O35 O29 O491

035 = little auto haemotherapy according to Windstosser

Change of redox equivalents under different O3-therapies

time: 10 min.

049 = hyperbaric 03-therapy




11

0

100

200

300

400

500

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18

mm

Hg

clearplasma

arterial blood

venous blood

erythrocytesconcentrate

528 mm Hg 773,6 mm HgPo2


12

1 = blank value: Venous blood

2 = major autohemotherapy with O2/O3

3 = Venous blood after treatment as per [2]

4 = hyperbaric ozone therapy

5 = Venous blood after treatment as per [4]

6 = blank value: Arterial blood

7 = Arterial blood after hyperbaric O3-therapy

8 = Arterial blood after hyperbaric O3-therapy by arterial reinfusion

9 = blank value: Erythrocytes concentrate

10 = major autohemotherapy vol. blood : gas = 3 : 1

11 = major autohemotherapy vol. blood : gas = 1 : 1

12 = hyperbaric ozone-therapy

13 = hyperbaric extracorporeal O2-therapy

14 = blank value blood plasma

15 = major autohemotherapy vol. Plasma : gas = 3 : 1

16 = clear O2 vol. plasma : gas = 1: 1

17 = major autohemotherapy vol. plasma : gas = 1 : 1

18 = hyperbaric ozone-therapy vol. plasma : gas = 1 : 1

Highest value 773,6 mmHg at 18.


Effect of hyperbaric O3-therapy on cholesterol in vivo

13

Dr. Kief 1978


Effect of hyperbaric O3-therapy on cholesterol in vivo

14

Dr. Kief 1978


15

„Sideeffects“ on Liverenzyms on the same population


16



17



Treatment of chronic Hepatitis by hyperbaric O3 therapy

18

transminases

initials SGOT SGPT Gamma GT

caH* before react. after before react. after before react. after

N. Th. + 342 160 27 602 466 62 167 44 35

+ 259 267 802 446 50 102

Sch. H. + 19 17 15 29 23 7 15 14 10

Sch. E. + 180 103 9 331 153 10 88 27 11

Z. K. H. + 115 245 16 248 265 22 223 82 28

H. Kl. + 73 464 67 116 986 116 109 271 77

K. F. + 153 149 10 476 344 23 133 129 19

W. K. + 34 94 66 39 187 125 48 61 48

G. K. 52 71 13 143 198 25 61 67 16

S. E. + 47 63 15 99 118 21 83 74 26

R. C. + 320 24 645 38 30

H. H. 143 13 270 20 27 13

M. H. J. 52 21 97 39 22 36

H. H. + 165 16 278 20 27

P. J. + 25 17 18 55 33 28 42 18 26

O. K. + 53 8 69 10 449 22

Gl. E. + 24 17 12 71 82 20 267 285 91

L. K. + 29 31 242 20 244 4

Sch. J. + 166 26 339 42 54 11

R. B. + 43 40 14 45 51 12 27 47 11

A. O. + 56 91 30 98 150 44 33 20

G. J. 15 16 9 17 14 9 27 26 18

B. K. + 37 91 27 45 87 27 25 79 17

SGOT SGPT Gamma GT

average value 107 115 22 230 218 34 109 84 27

diffusion 96 114 16 219 234 30 109 80 21

t-test 3,840 20 degr.of fr. 4,217 20 degr.of fr. 3,404 19 degr.of fr.

(p<0,002) (p<0,001) (p<0,01)

caH* before react. after before react. after before react. after

average value + 113 130 24 244 242 36 121 95 29

diffusion 100 120 17 229 249 33 113 84 22

* (caH = chronic aggressive hepatitis, histological evidence)


19

Treatment of chronic hepatitis with hyperbaric O3-therapy

Dr. Kief 1983 Blanc value Reactive phase result


20

The formation of hydrogen peroxide by neutrophils


21

The killing of Staphylococcus by neutrophils


22

Some „Abnormal“ Ozonization Reactions


23

0

0,1

0,2

0,3

0,4

0,5

0,6

0,7

0,8

0,9

1

1,1

before therapy after therapy

OK

T 4

ab

so

lute

(t

ho

us

an

d)

spectrum average +/- stand. deviation Δ

n=15

Hyperbaric ozone-therapy

treatment of ARC- and AIDS-patients


24

20,0%

25,0%

30,0%

35,0%

40,0%

45,0%

50,0%

55,0%

60,0%

65,0%


OK

T 8

re

lati

ve


n=15




25

0,1

0,2

0,3

0,4

0,5

0,6

0,7

0,8

0,9

1

1,1

1,2

1,3

1,4

1,5


Qu

oti

en

t O

KT

4/O

KT

8


n=15




26

0%

10%

20%

30%

40%

50%

60%

70%

P. G. S. R. R. H. I. P. N. H. M. D. A. H. K. D. P. M. B. V. Sch.Th.

P. A. H. A. V. S. M. V.

OK

T 8

re

lati

ve

before therapy

after therapy

initials




27

0

100

200

300

400

500

600

first last

T4

Examination

Patients with two or more Values were included in this analysis

T4 values Median and Quantiles

Kief clinic (N=30)

Q3

Q1

Med. 217

273

Hyperbaric O3-therapy and AHIT on HIV+ patients


28

300

400

500

600

700

800

900

1000

1100

first last

Examination

Patients with two or more values were included in this analysis


Kief clinic (N=30)

T8

Q3

Q1

Med. 648

806



29

0

0,2

0,4

0,6

0,8

first last

Examination

Patients with two ore more Values were included in this analysis

T4/T8 ratio Median and Quantiles

Kief Clinic (N=30)

T4/T8

Q3

Q1

Med. 0.33 0.35



30

400

500

600

700

800

900

1000

1100

1200

1300

first last

Examination

Patients with two ore more values were included in this analysis


Kief and Sacher clinics (N=164)

T8

Q3

Q1

Med. 846

802



31

100

200

300

400

500

600

first last

Examination



Kief and Sacher Clinics (N=164)

Q3

Q1

Med. 339

289

T4



32

0

0,2

0,4

0,6

0,8

first last

Examination


T4/T8 ratio Median and Quantiles

Kief and Sacher Clinics (N=164)

Q3

Q1

Med. 0.36 0.34

T4/T8



33

0

0,1

0,2

0,3

0,4

first lastExamination

Patients with 2 or more values were included in this analysis

(p-value of the Wilcoxon U-test)

T4/T8 ratio AHIT in comparison with no AHIT

Kief and Sacher clinics (N=164) vs. Conservative treatment (AZT) (N=20)

T4/T8

AHIT

P = 0.147

mean observation time

Kief+Sacher: 414 days cons. treatm. (AZT): 363 days

0.362

0.293

0.343

0.223

Conservative treatment



34

0

0,1

0,2

0,3

0,4

first lastExamination

Patients with 2 ore more values were included in this analysis

(p-value oft the Wilcoxon U-test)

T4/T8 ratio AHIT in comparison with no AHIT

Kief Clinic (N=30) vs. conservative treatment (AZT) (N=20)

T4/T8

mean observation time

Kief: 291 days cons. treatm. (AZT): 363 days

P = 0.337 P=0.020

Kief 0.324

0.293

0.352

0.223



35

0

5

10

15

20

25

30

4 7 10 13 17 21 24 28

CP

M -

TH

OU

SA

ND

S

uninfected control

infected - no ozone

infected - 45µg/ml O3

infected - 55 µg/ml O3

days

Reverse transcriptase activity

supernatant cultures


Effect of 1g Vitamin C in 500 ml “old” Transfusionblood

36

0

50

100

150

200

250

300

350

400

450

venous blood + 8.000 µg ozon + 8.000 µg ozon + vitamin C

PO2

up to 3 times with O2-O3 mix admitted


37

Vitamin C and Dehydroascorbic Acid


38

Effect of hyperbare ozonetherapy on leucocytes from

immunsupressed patients


39

Comparison: leucocytes in peripheral blood with hyperbaric

Ozone therapy (+1g vitamin C) (malignant patients)


40

8

8,5

9

9,5

10

10,5

11

11,5

prior to therapy in vitro after therapy

red

ox c

on

cen

trati

on

in

ven

ou

s b

loo

d i

n m

Val/

l

patients with malignancy (n=8)

other diagnoses (n=17)

Redox concentration in venous blood before and after

hyperbaric ozone therapy


41

8

8,5

9

9,5

10

10,5

11

11,5

prior to therapy after therapy

red

ox c

on

cen

trati

on

in

ven

ou

s b

loo

d i

n m

Val/

l

patients with malignancy (n=13)

other diagnoses (n=35)

Redox concentration in venous blood before and after hyperbaric ozone therapy


Interactions between ozone and other medications


43

-Repairs 2-3-DPG-shunt, enhances the O2-saturation of „old“ erythrocytes

-Reduces the tendency for fermentation of some malignancies

1.Vitamin C


44

Sideeffects: If patients has a tendency for diabetic metabolism it can introduce a reversible diabetes.


45

- Protects cellmembrans against free radicals

- Reduces haemolysis of high dosages of ozone at the major autohaemotherapy

-Must be given in the therapy interval - 24h before therapy

2. Vitamin E


46

- Produces together with ozone hydroxylanions (OH

.)

- NFT and O3 are together a really potent „cytostatic“

- Has the same sideeffcts like strong cytostatics if long time used: neuropathy especially

- Has compared to classic cytostatics less shorttime sideeffects like nausea, weakness etc.

- Look on the drug information is necessary

3. Nitrofurantoin


47

For long time ozone- treatment are trace minerals nessecary


48

- Se++ for Selenperoxydase 300 mg/day - Mn++ for Mangansuperoxydismutase 5-10 mg/day - Zn++ for Zinksuperoxydismutase 40mg/day


Thank you for your attention

Documents

Basic values of ozone-therapy - HUMARES GMBHhumares.de/files/fallbeispiele/basic-values-of-ozone-therapy.pdf · Treatment of chronic Hepatitis by hyperbaric O3 therapy 18 transminases