B&B drug game

7/31/2019 B&B drug game

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B&B Drug Game

Because drugs are fun!


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Disclaimer:

In this slideshow, there ARE guaranteed,typos, errors, and mistakes indeed!

But the notes were so dry and terribly boring,

powerpoints the only way to keep me from snoring.Although this is shoddy and not very pretty,it makes B&B drugs less dreadful and shitty!

Seriously though dont hold me to any of this.I hope it helps more than it hurts :)

~cy


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Propofol

Anaesthetics (IV)

IND:rapid induction of hypnosis (but no

analgesia!)

MOA:inhib via GABA-A


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Lamotrigine

Anti-convulsants

MOA:blocks V-gated Na+ channels,

inhibits Glutamate release


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Haloperidol

Anti-psychotics (Typical)

IND:

psychosis (2nd line)MOA:

blocks DA D2-Rs in mesolimbic ,

mesocortical, and nigrostriatal pathwaysAffinity?

LOW


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Dihydroergotamine (DHE)

ErgotaminesIND:

acute migraines (less common than

triptans)

MOA:

5-HT agonism vasoconstriction,

substance P + CGRP


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Nortriptyline

TCAs - 2ndary

IND:

Depression (3rd line), Diabetic Neuropathy,

postherpetic VZV pain, migraine prophylaxis

MOA:

inhibition of serotonin NE reuptake NE + 5-

HT endogenous desc pain mod.


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Baclofen

Anti-spastics

IND:

UMN lesion spasticityMOA:

GABA-B Agonist HiPolarization

of pre-syn. terminal NT release


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TriazolamBenzodiazepines

IND:

anxiety (1st line except PTSD/OCD),

insomnia, agitation, seizures, MM

spasm, EtOH withdrawal, pre-

medication for surgical procedure

MOA:

binds GABA-A activity (inh)

=

2hrs


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Venlafaxine

SNRIs

IND:

depression (2nd line), anxiety (1st line -OCD),

chronic pain, mood disorders

MOA:

selective inhibition of 5-HT + NE reuptake

(NOT DA)NE prevents DA from being

pumped into predominately NE synapses

enhances DA transmission positive affect


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Tramadol

Opiods

IND:

3rd line for chronic pain, amputationlow abuse potential

MOA:

weak -agonism inh. 5-HT + NEreuptake peripheral anesthesia


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Tertrabenazine

Anti-dopaminergics

IND:

hyperkinetic disorders: Huntingtons,Ballismus, Tardive Dyskinesia, etc.

MOA:

VMAT-inh. DA


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Fluoxetine

SSRIs

IND:

depression (1st line), anxiety (1st line), migraine

prophylaxis, eating disorders

MOA:

selective inhibition of serotonin reuptake (NOT

NE and dopamine)

=

2-3d


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Sumatriptan

Triptans

IND:

acute migraines (very good!)

MOA:

5-HT agonism vasoconstriction, substance P

+ CGRP

ContraIndication:

Coronary Artery Disease! ( use ergotamines)


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Oxcarbazepine

Anti-convulsants

MOA:blocks V-gates Na channels, K+

leak


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Clonazepam

Benzodiazepines

IND:





MOA:



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Zopiclone

NOT a benzoIND:

short term insomnia, 2nd year

medical school examsMOA:


(same as Benzos)


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Mirtazapine

NDRIs

IND:

depression (2nd line)

MOA:

weak inh. NE & DA reuptake (NOT

5-HT) NE & DAauto-inh.


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Methylsergide

Serotonin Agonists

IND:

migraine prophylaxisMOA:

5-HT receptor agonism


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MAOi

MONOAMINE OXIDASEINHIBITOS

IND:

depression (last resort)MOA:

inh. NT degredation DA, NE, 5-

HT


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Clozapine

Anti-psychotics (Atypical)

IND:

schizos who are Tx-resistant to othermeds

SE:

risk of agranulocytosis and seizures


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Gabapentin

Anti-convulsants

IND:

any chronic neuropathic pain,

partial seizures

MOA:

2-1 subunit of pre-synaptic Ca++

channelsrelease of Glutamate,

NE, substance P, CGRP, anti-

allodynic effect


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Diazepam

BenzodiazepinesIND:


insomnia, agitation, seizures, MMspasm, EtOH withdrawal, pre-


MOA:binds GABA-A activity (inh)

=

20-100hrs


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Reboxetine

NRIs

IND:

Depression (not very effective),panic disorder, ADHD

MOA:

inh. NE reuptake (NOT 5-HT or DA)NEauto-inh.can be

combined w/ SSRI


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Phenytoin

Anti-convulsantsIND:

partial seizures, post-head trauma

MOA:blocks V-gated Na+ channels


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Rivastigmine

AChEi

IND:

Sx-treatment for Alzheimers (notdisease-modifying)

MOA:

inhibits acetylcholinesterase Achtransmission


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Escitalopram

SSRIsIND:



MOA:


NE and dopamine)


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Memantine

Glutamate NMDA blocker

IND:

Sx-treatment for Alzheimers (notdisease-modifying)

Used in combo w/:

Acetylcholinesterase inhibitors


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Tacrine

AChEiIND:

Sx-treatment for Alzheimers (not

disease-modifying)MOA:

inhibits acetylcholinesterase Ach

transmission


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CarbamazepineAnti-convulsants

IND:

partial serizures, tonic-clonic,

bipolar, trigeminal neuralgia

MOA:

blocks V-gated Na+ channels


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Oxazepam

Benzodiazepines

IND:





MOA:



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Topiramate

Anti-convulsants

IND:


blocks V-gated Na+ channels,

inhibits Glutamate release, GABA-A


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Citalopram

SSRIsIND:



MOA:


NE and dopamine)


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L-DOPA

Dopamine PrecursorIND:

Parkinsons and DA-responsive

dystoniaMOA:

DA precursor that crosses the BBB


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Paroxetine

SSRIsIND:



MOA:


NE and dopamine)

SE:

notorious w/drawal RXN


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Duloxetine

SNRIsIND:

depression (2nd line), anxiety (1st line -OCD),

chronic pain, mood disorders

MOA:

selective inhibition of 5-HT + NE reuptake

(NOT DA)NE prevents DA from beingpumped into predominately NE synapses

enhances DA transmission positive affect


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Imipramine

TCAs - 3aryIND:



MOA:




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Sertraline

SSRIsIND:



MOA:


NE and dopamine)


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Clorpromazine

Anti-psychotics (Typical)

IND:

psychosis (2nd

line)MOA:

blocks DA D2-Rs in mesolimbic , mesocortical,

and nigrostriatal pathwaysAffinity?

LOW


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Amitriptyline

TCAs - 3aryIND:



MOA:




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Donepezil

AChEiIND:




transmission


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Levitiracetam

Anti-convulsants

IND:

absence seizuresMOA:

blocks T-type Ca++ channels in

thalamic neurons


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Desipramine

TCAs - 2ndaryIND:



MOA:




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Buproprion

NDRIs

IND:

depression (2nd line)

MOA:

weak inh. NE & DA reuptake (NOT

5-HT) NE & DAauto-inh.


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Pregabalin

Anti-convulsants

IND:

any chronic neuropathic pain,partial seizures

MOA:

2-1 subunit of pre-synaptic Ca++channelsrelease of Glutamate,

NE, substance P, CGRP, anti-

allodynic effect


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Galantamine

AChEiIND:




transmission


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Ethosuximide

Anti-convulsants

IND:

absence seizuresMOA:

blocks T-type Ca++ channels in

thalamic neurons


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KetamineAnaesthetics (IV)

IND:

trauma/shock/burn Pts, battlefieldsurgery, date rape, raves

MOA:

stim via antag. NMDA (Glutamate)


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Barbituates

MOA:

GABA-A activity


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Li+

Mood StabilizersIND:

Bipolarbefore atypical anti-

psychoticsMOA:

interferes w/ 2nd messenger of amine

activity overactive NT activity


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Valproate

Anti-convulsants

IND:

absence seizures; migraineprophylaxis

MOA:

GABA-A, blocks V-gated Na+channels


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Naloxone

Opiod Antagonists

IND:

opiod ODMOA:

Blocks opiod receptors


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Risperidone

Anti-psychotics (Atypical)

IND:

psychosis (1st

line), bipolar (w/ mood stabilizer)MOA:

blocks both 5-HT-2A and DA-D2 receptors in

same pathways as typicalsSE:

EPSx, more benign SE, but metabolic SE:

wt, D.M., metabolic syndrome


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Naltrexone

Opiod Antagonists

IND:

opiod ODMOA:

Blocks opiod receptors


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Lorazepam

BenzodiazepinesIND:


insomnia, agitation, seizures, MMspasm, EtOH withdrawal, pre-


MOA:binds GABA-A activity (inh)


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Pizotifen

Serotonin Agonists

IND:


5-HT receptor agonism


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Thiopental

Anaesthetics (IV)MOA:

inhib via GABA-A


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Trazodone

SARI (Serotonin Agonist & Reuptake Inhibitor)

IND:

anxiety, insomnia, chronic pain, depression(poor), mood disorders

MOA:

5-HT-2A antagonist effect of 5-HTHiActivity


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Fluvoxamine

SSRIsIND:


prophylaxis, eating disordersMOA:


NE and dopamine)


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ALL DONE!

GOODLUCK!

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B&B drug game