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Bimonthly Meeting on Sep. 26, 2008
MRS on Exam 4465
Amarjeet Bhullar
We have compared metabolite ratios, calculated using three different methods:
• Directly Generated by Functool
• Metabolites Concentration Generated by
Functool
• Gaussian Function Overlapped on metabolite peak
S19.6
Exam ID: 4465June 23, 2008
Patient Name:
AD
Chemical Information on S9.6
50 100 150 200 2500
140
280
420
560
Sig
nal
(M
R U
nit
s)
Voxel # 16
Image Number
Real Spectrum
50 100 150 200 250-200
-100
0
100
Sign
al (
MR
Uni
ts)
Voxel # 20
Real Spectrum
Image Number
50 100 150 200 250-300
0
300
600
Image Number
Sig
nal
(M
R U
nit
s)
Voxel # 23
Real Spectrum
50 100 150 200 250
-400
-200
0
200
400
600
Image Number
Sig
nal
(MR
Un
its)
Real Spectrum
Voxel # 24
Chemical Information on S9.6
50 100 150 200 250-150
0
150
300
450
Sig
nal
Number of Image
Real Spectrum
Voxel # 25
50 100 150 200 250-200
0
200
400
600Voxel # 26
Sig
nal
(M
R U
nit
s)
Image Number
50 100 150 200 250
-200
0
200
400
600
Sig
nal
(M
R U
nit
s)
Image Number
Real Data
Voxel # 27
50 100 150 200 250
0
150
300
450
Sig
nal
(M
R U
nit
s)
Image Number
Real Spectrum
Voxel # 30
Chemical Information on S9.6
50 100 150 200 250-300
-200
-100
0
100
Real Spectrum
Voxel # 31
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
-100
0
100
200
300
400Voxel # 32
Real Spectrum
Image Number
Sig
nal
(M
R U
nit
s)
50 100 150 200 250-100
0
100
200
300
400
500
Real Spectrum
Voxel # 33
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
200
400
Sig
nal
Image Number
Real Spectrum
Voxel # 34
Chemical Information on S19.6
50 100 150 200 2500
500
1000
1500
2000
Sig
nal
(M
R U
nit
s)
Image Number
Real Spectrum
Voxel # 16, S19.6
50 100 150 200 250-800
-600
-400
-200
0
200
400
Sig
nal
(M
R U
nit
s)
Image Number
Real Spectrum
Voxel # 17, S19.6
50 100 150 200 250
0
200
400
600
800
1000
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 19, S19.6
50 100 150 200 250
-200
0
200
400
600
800Voxel # 23, S19.6
Real SpectrumS
ign
al (
MR
Un
its)
Image Number
Chemical Information on S19.6
50 100 150 200 250-800
-600
-400
-200
0
200
400
Voxel # 24, S19.6
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
400
800
1200Voxel # 25, S19.6
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
50 100 150 200 2500
200
400
600
800
1000
1200
1400
Real Spectrum
Voxel # 26, S19.6
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
-200
0
200
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 27, S19.6
Real Spectrum
Chemical Information on S19.6
50 100 150 200 2500
200
400
600
800
1000
1200
Real Spectrum
Voxel # 30, S19.6
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
200
400
600
800
1000Voxel # 31, S19.6
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
50 100 150 200 2500
400
800
1200Voxel # 32, S19.6
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
400
800
1200Voxel # 33, S19.6
Sig
nal
(M
R U
nit
s)
Image Number
Real Spectrum
Chemical Information on S19.6
50 100 150 200 250
0
200
400
600Voxel # 34, S19.6
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
50 100 150 200 250-600
-400
-200
0
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 39, S19.6
50 100 150 200 2500
200
400
600
800
1000
1200
Real Spectrum
Voxel # 38, S19.6
Sig
nal
(M
R U
nit
s)
Image Number
Chemical Information on I0.4
50 100 150 200 2500
300
600
900 Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 16, I0.4
50 100 150 200 250
0
200
400
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 19, I0.4
50 100 150 200 250
0
200
400
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 20, I0.4
50 100 150 200 250
-600
-400
-200
0
200
Real SpectrumSig
nal
(M
R U
nit
s)
Image Number
Voxel # 24, I0.4
Chemical Information on I0.4
50 100 150 200 2500
300
600
900
1200Voxel # 25, I0.4
Real Spectrum
Sign
al (
MR
Uni
ts)
Image Number50 100 150 200 250
0
300
600
900
1200
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 26, I0.4
50 100 150 200 250
-200
0
200
400
600
Real Spectrum
Voxel # 27, I0.4
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
300
600
900
1200
Real SpectrumS
ign
al (
MR
Un
its)
Image Number
Voxel # 30, I0.4
Chemical Information on I0.4
50 100 150 200 250-800
-600
-400
-200
0
Voxel # 31, I0.4
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
200
400
600
800
1000
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 32, I0.4
50 100 150 200 2500
300
600
900
1200Voxel # 33, I0.4
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number50 100 150 200 250
0
300
600
900
1200
Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 34, I0.4
Chemical Information on I0.4
50 100 150 200 2500
500
1000
1500
Sig
nal
(M
R U
nit
s)
Image Number
Real Spectrum
Voxel # 37, I0.4
50 100 150 200 250-300
-200
-100
0
100
Real Spectrum
Image Number
Sig
nal
(M
R U
nit
s)
Voxel # 38, I0.4
50 100 150 200 250-100
0
100
200
300
400 Real Spectrum
Sig
nal
(M
R U
nit
s)
Image Number
Voxel # 40, I0.4
50 100 150 200 250
0
300
600
900
1200S
ign
al (
MR
Un
its)
Image Number
Voxel # 41, I0.4
Real Spectrum
0.6
0.8
1.0
1.2
1.4
1.6
1.8 F1 F2 Our Calculation
Cho
/Cre
Voxel #
S9.6
Metabolite Ratios Cho/Cre and Cho/NAA
0.0
0.4
0.8
1.2
1.6 F1 F2 Our Calculation
Voxel #C
ho/N
AA
S9.6
Metabolite Ratios Cho/Cre and Cho/NAA
0.0
0.5
1.0
1.5
2.0
2.5
3.0
Voxel #
Cho
/Cre
S19.6 F1 F2 Our Calculation
0.0
0.2
0.4
0.6
0.8
1.0 F1 F2 Our Calculation
S19.6
Voxel #C
ho/N
AA
Metabolite Ratios Cho/Cre and Cho/NAA
0.0
0.4
0.8
1.2
1.6
2.0
Voxel #
Cho
/Cre
F1 F2 Our Calculation
I0.4
0.0
0.2
0.4
0.6
0.8
1.0
F1 F2 Our Calculation
I0.4
Voxel #C
ho/N
AA
Conclusion:
There is no significant difference between our calculation and Functool.
Suggestions are welcome
